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1.
Adv Mind Body Med ; 35(4): 24-28, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34734846

RESUMO

Context: Obesity is associated with chronic diseases, including metabolic syndrome and cardiovascular diseases (CVDs). Fasting is commonly employed by obese people to reduce their weight. Likewise, yoga and naturopathy (YN) that include liquid fasting (LF) have been shown to be beneficial in reducing weight for people with metabolic disorders. However, the safety of LF during YN treatments and its effects on metabolic and cardiovascular risk factors haven't yet been reported. Objective: The study intended to evaluate the safety of LF during YN treatments and its effects on metabolic and cardiovascular risk factors in people with obesity. Design: A single-group, pretest-and-posttest design was adopted for the study. Setting: The study took place in a YN hospital located in South India. Participants: Participants were 176 obese people aged between 18 and 65 years. Intervention: Together with YN treatments, all participants underwent LF using lime juice with jaggery, ash guard juice, vegetable soup, buttermilk, and kokum juice for a period of 5 consecutive days. Outcome Measures: Assessments such as body weight, body mass index (BMI), fat mass, lipid profile, and blood pressure were taken at baseline and postintervention. Results: Participants showed a significant reduction in body weight, BMI, fat mass, triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), very-low-density lipoprotein cholesterol (VLDL-C), high-density lipoprotein cholesterol (HDL-C), systolic blood pressure (SBP), and diastolic blood pressure (DBP). Conclusions: The results suggest that LF during YN treatment canbe effective in reducing metabolic and cardiovascular risk factors in people with obesity.


Assuntos
Doenças Cardiovasculares , Naturopatia , Ioga , Adolescente , Adulto , Idoso , Pressão Sanguínea , Doenças Cardiovasculares/terapia , Jejum , Fatores de Risco de Doenças Cardíacas , Humanos , Pessoa de Meia-Idade , Obesidade/terapia , Fatores de Risco , Adulto Jovem
2.
Ceska Gynekol ; 86(5): 343-348, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34736334

RESUMO

Polycystic ovary syndrome (PCOS) is a common pathological condition in women. Conservative treatment is used in the treatment of polycystic ovary syndrome. Conservative treatment options include increased physical activity and diet. The main aim of the article is to discuss the therapeutic treatment of influencing PCOS from a nutritional point of view. PCOS is associated with several comorbidities, including infertility, metabolic syndrome, obesity, impaired glucose tolerance, diabetes mellitus II, and increased cardiovascular risk. Several therapeutic diets can be used in the treatment of PCOS, such as the DASH diet, the low-carbohydrate diet, and a diet based on a low glycemic index. A change in eating habits is associated with improvement in PCOS symptoms.


Assuntos
Intolerância à Glucose , Resistência à Insulina , Síndrome do Ovário Policístico , Dieta , Feminino , Humanos , Obesidade/complicações , Obesidade/terapia , Síndrome do Ovário Policístico/complicações , Síndrome do Ovário Policístico/terapia
3.
Front Public Health ; 9: 749302, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34746084

RESUMO

Background: Few comprehensive lifestyle intervention programmes have been investigated on overweight and obese adults in China. This study was to evaluate the effect of a 36-month weight management programme on weight loss and its maintenance among overweight and obese patients in Ningbo, China. Methods: Adults with BMI ≥24kg/m 2 enrolled in this programme, including nutritional, physical activity, psychological and endocrinological counselling sessions, from July 2015 to January 2020. Adults participated in face-to-face counselling sessions and group-based education. Then, participants joined 21-day intensive programme using Bohe health APP and WeChat group to get personal advice of nutrition and lifestyle. In the end, participants were requested to join 33-month follow-ups including face-to-face counselling and personal advice on WeChat group. The main outcome was to evaluate the changes in weight at each followup from baseline weight. Results: In total, 692 adults participated in this entire weight management programme. During follow-ups, 579, 475, 299, 219, and 135 adults participated at 3, 6, 12, 24, and 36 months, respectively. All participants had a significant initial weight loss at 3 months, then maintained the weight loss during 33-month follow-ups. At 36 months, 11.0%, 6.4%, and 3.5% of all participants achieved 5%, 10%, and 15% weight loss from the baseline weight, respectively. Adjusted weight at 36 months was significantly reduced from the baseline weight in both sex (-7.2 kg). Conclusion: This weight management programme is suggested to benefit to reduce initial body weight and maintain long-term weight loss among overweight and obese adults.


Assuntos
Programas de Redução de Peso , Adulto , China , Humanos , Obesidade/terapia , Sobrepeso/terapia , Perda de Peso
4.
Artigo em Inglês | MEDLINE | ID: mdl-34769633

RESUMO

The objective of this study was to analyze the effectiveness of two nonpharmacological interventions-traditional Brazilian diet (DieTBra), and extra-virgin olive oil (EVOO)-in terms of the reduction in pain and pain intensity in individuals with severe obesity. We conducted a 12-week parallel randomized clinical trial with 149 individuals (body mass index (BMI) ≥ 35 kg/m2) who were randomized into three groups: supplementation with EVOO (n = 50), DieTBra (n = 49), and EVOO + DieTBra (n = 50). Of the total, 133 individuals with a mean BMI of 46.04 kg/m2 completed the study. By the end of the follow-up, there was a reduction in severe pain in the EVOO + DieTBra group (p = 0.003). There was a significant reduction in severe pain in the EVOO + DieTBra group (-22.7%); pain in the wrist and hand (-14.1%), upper back (-26.9%), and knees (-18.4%) in the DieTBra group; and reduction in hip pain (-11.1%) with EVOO consumption. We conclude that EVOO and DieTBra, either alone or in combination, are effective interventions to reduce pain intensity and pain in different regions in individuals with severe obesity, and have great potential for clinical application.


Assuntos
Obesidade Mórbida , Obesidade , Dieta , Humanos , Obesidade/terapia , Obesidade Mórbida/terapia , Azeite de Oliva , Dor
5.
Eur J Gen Pract ; 27(1): 331-338, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34779698

RESUMO

BACKGROUND: Despite the accumulated evidence suggesting the positive aspects of using group visits in obesity, the number of qualitative studies that examine why and how the effects occur at an individual level is limited. OBJECTIVES: This qualitative study aimed to explore the experiences and perspectives of women who participated in group visits and had different weight loss outcomes in the programme. METHOD: Purposive maximum variation sampling was performed. Data collection and analysis were performed iteratively, and the data saturation method was used as a guideline for sample size. All participants who completed the group visits were approached, and finally, 20 individuals were included in the study. Semi-structured in-depth interviews were audio-recorded, transcribed verbatim, and analysed thematically using a phenomenological approach. RESULTS: The mean age of the individuals was 38.5 ± 9.8 years, the education level ranged from incomplete-high school to university degree, and the weight changes were between +4.1% and -17.1%. Two main themes emerged from the thematic analysis revealing barriers: weight stigma (two sub-themes: internal and external stigma) and traumatic life events (three sub-themes: 'loss of relatives,' 'childhood traumas,' and 'conflicting intimate partner relationships'). CONCLUSION: Considering the barriers to weight loss efforts in this study, these issues need to be explicitly investigated before and during the group visits in addition to weight loss practices and behavioural changes.


Assuntos
Obesidade , Atenção Primária à Saúde , Adulto , Feminino , Humanos , Pessoa de Meia-Idade , Obesidade/terapia , Pesquisa Qualitativa , Perda de Peso
6.
Nurs Clin North Am ; 56(4): 495-509, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-34749890

RESUMO

Obesity is a chronic, progressive, and relapsing disease state the management of which includes a comprehensive, long-term management plan. Comprehensive management of obesity includes 4 key components of care: nutrition, behavioral intervention, physical activity, and clinical management. This article reviews current evidence-based treatment of obesity and key components for all clinicians to have knowledge of.


Assuntos
Terapia Comportamental , Dieta Mediterrânea , Medicina Baseada em Evidências , Exercício Físico , Obesidade/terapia , Humanos , Estado Nutricional
7.
Nurs Clin North Am ; 56(4): 511-525, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-34749891

RESUMO

Obesity is a strong independent predictor of cardiovascular disease. In this article, we briefly review the physiologic effects of obesity on the cardiovascular system, discuss how obesity influences history taking, physical assessment, diagnostic testing, and treatment of patients with common cardiovascular conditions such as hypertension, coronary heart disease, and chronic heart failure. Implications for nursing practice will be shared with a focus on lifestyle modifications to be included in patient education.


Assuntos
Doenças Cardiovasculares , Dieta Redutora , Exercício Físico , Estilo de Vida , Adulto , Doenças Cardiovasculares/complicações , Doenças Cardiovasculares/terapia , Humanos , Hipertensão , Obesidade/fisiopatologia , Obesidade/terapia , Fatores de Risco
8.
Nurs Clin North Am ; 56(4): 543-552, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-34749893

RESUMO

Obesity and nonalcoholic fatty liver disease (NAFLD) have a significant global impact, and their complications are quickly becoming a reason for primary care visits and hospitalizations. This article provides an overview of NAFLD and obesity, pathogenesis of NAFLD and nonalcoholic steatohepatitis, clinical presentation and diagnostic criteria, and a review of practice guidelines. The current mainstay of treatment for NAFLD are lifestyle modifications and include a plan to eat, move, and change behavior. The future holds potential for new drug therapies in treating NAFLD. More research is needed to move these treatments forward.


Assuntos
Doenças Cardiovasculares/etiologia , Dietoterapia , Exercício Físico , Hepatopatia Gordurosa não Alcoólica/complicações , Hepatopatia Gordurosa não Alcoólica/fisiopatologia , Obesidade , Humanos , Hepatopatia Gordurosa não Alcoólica/tratamento farmacológico , Obesidade/fisiopatologia , Obesidade/terapia , Comportamento Sedentário
9.
Nurs Clin North Am ; 56(4): 599-607, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-34749898

RESUMO

The health outcomes of men are significantly worse, when compared with their female counterparts, for the top 15 leading causes of death nationwide. At this time, men are not actively engaged in the health care system, creating a challenge for those managing patients in the clinical setting. The premature morbidity and mortality of men financially burdens the health care system and places a financial strain in secondary and tertiary preventive care that is simply not sustainable. Obesity is a catalyst that fuels disease and is directly responsible for the pathogenesis for the disease claiming the lives of men nationwide.


Assuntos
Adiposidade , Masculinidade , Saúde do Homem , Obesidade , Atenção Primária à Saúde , Estigma Social , Atitude Frente a Saúde , Humanos , Masculino , Obesidade/epidemiologia , Obesidade/terapia , Atenção Primária à Saúde/organização & administração , Fatores Sexuais , Estados Unidos/epidemiologia
10.
BMJ ; 375: n2771, 2021 11 22.
Artigo em Inglês | MEDLINE | ID: mdl-34810160

RESUMO

The studyAbbott S, Smith E, Tighe B, Lycett D. Group versus one-to-one multi-component lifestyle interventions for weight management: a systematic review and meta-analysis of randomised controlled trials. J Hum Nutr Diet 2021;34:485-93.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/group-weight-loss-programmes-more-effective-than-one-to-one-sessions/.


Assuntos
Obesidade/terapia , Psicoterapia de Grupo , Perda de Peso , Programas de Redução de Peso/métodos , Terapia Comportamental , Dieta Redutora , Terapia por Exercício , Humanos , Obesidade/dietoterapia , Obesidade/psicologia , Reino Unido
11.
Surg Clin North Am ; 101(6): 981-993, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34774276

RESUMO

Smoking and obesity are commonly encountered problems in the elective, perioperative setting. This article reviews the risks posed by smoking and diabetes and explores way to mitigate such risks. Other means of perioperative optimization are also discussed in an effort to describe perioperative strategies that can improve patient outcomes.


Assuntos
Complicações do Diabetes , Procedimentos Cirúrgicos Eletivos , Obesidade , Fumar , Comorbidade , Complicações do Diabetes/complicações , Procedimentos Cirúrgicos Eletivos/efeitos adversos , Humanos , Obesidade/complicações , Obesidade/terapia , Complicações Pós-Operatórias/prevenção & controle , Cuidados Pré-Operatórios , Fatores de Risco , Fumar/efeitos adversos , Abandono do Hábito de Fumar
12.
J Nutr Sci Vitaminol (Tokyo) ; 67(5): 292-300, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34719614

RESUMO

Metabolic syndrome (MS) is a combination of risk factors related to the development of mainly type 2 diabetes mellitus, cardiovascular disease (CVD) and nonalcoholic fatty liver disease (NAFLD). Its prevalence has increased worldwide, and healthcare systems will face major challenges in addressing this problem. The aim of this work was to evaluate the effect of hyperbaric oxygen therapy (HBOT) on insulin resistance (IR) and obesity associated with MS in Wistar rats. The experimental design consisted of three groups of sucrose-induced MS rats: the MS group that consumed sucrose (MS-Suc; n=5), the MS group that ingested sucrose and HBOT (MS-Suc-HBOT; n=5), the MS group that did not consume sucrose and that received HBOT (MS-HBOT; n=5) and the control group. The rats received HBOT for 20 d at 2.4 atmospheres absolute (ATA) for 60 min. Subsequently, the rats were euthanized, and body fat weight, serum biochemical parameters and microscopic analysis of adipose tissue were determined. Rats with hyperoxia had decreased body weight, adipose tissue hypertrophy, and abdominal and epididymal fat. Likewise, markers of insulin resistance (glucose, insulin and HOMA-IR), biochemical parameters of dyslipidemia (cholesterol and triglycerides) and nonalcoholic fatty liver (AST and ALT) decreased; in contrast, compared to the control group, HBOT increased the 1/HOMA-IR, HOMA-ßCell and McAuley indexes, which were related to the improvement in insulin sensitivity (p<0.05; p<0.01). HBOT showed beneficial effects in the treatment of IR and obesity associated with sucrose-induced metabolic syndrome in Wistar rats.


Assuntos
Diabetes Mellitus Tipo 2 , Oxigenação Hiperbárica , Resistência à Insulina , Síndrome Metabólica , Obesidade Abdominal , Animais , Sacarose na Dieta , Síndrome Metabólica/terapia , Obesidade/terapia , Obesidade Abdominal/terapia , Ratos , Ratos Wistar
13.
J Med Internet Res ; 23(11): e28185, 2021 11 16.
Artigo em Inglês | MEDLINE | ID: mdl-34783674

RESUMO

BACKGROUND: Smartphone apps have shown potential in enhancing weight management in Western populations in the short to medium term. With a rapidly growing obesity burden in Asian populations, researchers are turning to apps as a service delivery platform to reach a larger target audience to efficiently address the problem. OBJECTIVE: This systematic review and meta-analysis aims to determine the efficacy of interventions that incorporate apps in facilitating weight loss and health behavior change in the Asian population. METHODS: A total of 6 databases were searched in June 2020. The eligible studies included controlled trials in which an app was used in the intervention. The participants were aged 18 years or older and were of Asian ethnicity. A meta-analysis to test intervention efficacy, subgroup analyses, and post hoc analyses was conducted to determine the effects of adding an app to usual care and study duration. The primary outcome was absolute or percentage weight change, whereas the secondary outcomes were changes to lifestyle behaviors. RESULTS: A total of 21 studies were included in this review, and 17 (81%) were selected for the meta-analysis. The pooled effect size across 82% (14/17) of the randomized controlled trials for weight change was small to moderate (Hedges g=-0.26; 95% CI -0.41 to -0.11), indicating slightly greater weight loss achieved in the intervention group; however, this may not be representative of long-term studies (lasting for more than a year). Supplementing multicomponent usual care with an app led to greater weight loss (Hedges g=-0.28; 95% CI -0.47 to -0.09). Asian apps were largely culturally adapted and multifunctional, with the most common app features being communication with health professionals and self-monitoring of behaviors and outcomes. CONCLUSIONS: More evidence is required to determine the efficacy of apps in the long term and address the low uptake of apps to maximize the potential of the intervention. Future research should determine the efficacy of each component of the multicomponent intervention to facilitate the designing of studies that are most effective and cost-efficient for weight management. TRIAL REGISTRATION: PROSPERO CRD42020165240; https://tinyurl.com/2db4tvn6.


Assuntos
Aplicativos Móveis , Comportamentos Relacionados com a Saúde , Humanos , Estilo de Vida , Obesidade/terapia , Perda de Peso
14.
Mo Med ; 118(5): 442-445, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34658437

RESUMO

Importance: During the COVID-19 pandemic, telemedicine visits increased to provide safer access to healthcare. Methods: To evaluate the role of telemedicine in obesity management during COVID-19, we conducted a systematic review to identify barriers in using this approach to patient care. Conclusion: While necessary, the management of obesity through telemedicine was met with patient-specific and healthcare-specific barriers. Increased awareness of these barriers may allow physicians to better understand patient interactions via virtual medical visits.


Assuntos
COVID-19 , Telemedicina , Humanos , Obesidade/epidemiologia , Obesidade/terapia , Pandemias , SARS-CoV-2
15.
Zhen Ci Yan Jiu ; 46(10): 845-50, 2021 Oct 25.
Artigo em Chinês | MEDLINE | ID: mdl-34698458

RESUMO

OBJECTIVE: To observe the effect of electroacupuncture (EA) of different acupoint combinations on lipid metabolism and liver Toll-like receptor 4 (TLR4)/nuclear factor kappa B (NF-κB) signaling in obese rats, so as to explore the specificity of regulatory effects of different acupoints for obesity. METHODS: Male SD rats were randomly divided into normal control, model, hindlimb acupoint EA ï¼»"Fenglong" (ST40)-"Zusanli" (ST36), hindlimb EAï¼½, abdominal acupoint EA ï¼»("Zhongwan" (CV12)-"Tianshu" (ST25), "Guanyuan" (CV4) - the opposite ST25, abdominal EAï¼½, BiaoBen-acupoint EA ï¼»ST40-ST36, CV12 -CV4, ST25, BiaoBen EAï¼½ groups, with 10 rats in each group. The obesity model was induced by feeding the rats with high fat diet. EA (2 Hz, 1 mA) was applied to the acupoint groups mentioned above for 10 min (per acupoint group), 3 times a week for 8 weeks. After the treatment, the body weight and food intake in each group were recorded. The contents of serum total cholesterol (TC), triglyceride (TG), non-esterified fatty acid (NEFA) were detected by using an automatic biochemical analyzer. The expression levels of TLR4 and NF-κB p65 mRNAs and proteins in the liver tissue were detected by quantitative real-time PCR and Western blot, separately. RESULTS: Compared with the normal group, the body weight and food intake, serum TC, TG and NEFA contents, hepatic TLR4 and NF-κB p65 protein and gene expression were significantly increased in the model group (P<0.05, P<0.01). After the treatment, compared with the model group, the body weight, food intake, TC, TG, NEFA, TLR4 and NF-κB p65 protein and mRNA expression were significantly decreased in the hindlimb EA, abdominal EA and BiaoBen EA groups (P<0.05, P<0.01). Comparison among the 3 treatment groups showed that the serum TC, TG and NEFA contents were significantly lower in the hindlimb EA and BiaoBen EA groups than in the abdominal EA group (P<0.01,P<0.05). The expression levels of TLR4 and NF-κB p65 mRNAs and proteins were significantly lower in the BiaoBen EA group than in the hindlimb EA and abdominal EA groups (P<0.01, P<0.05). CONCLUSION: BiaoBen EA is superior to abdominal EA in improving lipid metabolism in obesity rats, which may be related to its stronger effectiveness in down-regulating hepatic TLR4/NF-κB p65 signaling.


Assuntos
Pontos de Acupuntura , Eletroacupuntura , Animais , Metabolismo dos Lipídeos/genética , Fígado , Masculino , NF-kappa B/genética , Obesidade/genética , Obesidade/terapia , Ratos , Ratos Sprague-Dawley , Ratos Wistar , Receptor 4 Toll-Like/genética
16.
J Res Health Sci ; 21(3): e00521, 2021 Sep 19.
Artigo em Inglês | MEDLINE | ID: mdl-34698655

RESUMO

BACKGROUND: Up to now, different diet therapeutics interventions have been introduced for the treatment of obesity. The present study aimed to compare the diet therapeutics interventions for obesity simultaneously. STUDY DESIGN: Systematic review and network meta-analysis METHODS: The major international databases, including Medline (via PubMed), Web of Science, Scopus, Cochrane Library, and Embase, were searched using a predesigned search strategy. Randomized controlled trials (RCTs) that had compared the diet therapy interventions were included. The mean difference with a 95% confidence interval was used to summarize the effect size in the network meta-analysis. The frequentist approach was used for data analysis. RESULTS: In total, 36 RCTs out of 9335 retrieved references met the inclusion criteria in this review. The included RCTs formed nine independent networks. Based on the results, Hypocaloricdiet+Monoselect Camellia (MonCam, P=0.99), energy restriction, behavior modification+exercise (LED) (P=0.99), sweetener at 20% of total calories (HFCS20)+Ex (P=0.67), catechin-richgreentea(650)+inulin (P=0.68), very low calorie diet (VLCD) (P=1.00), normal protein diet+resistance exercise (NPD+RT) (P=0.80), low-calorie diets+exercise (Hyc+Ex) (P=0.85), high-soy-protein low-fat diet (SD) (P=0.75), calorie restriction+behavioral weight loss (Hyc+BWL) (P=0.99) were the better treatments for weight loss in the networks one to nine, respectively. CONCLUSION: Based on the results of network meta-analysis, it seems that Hypocaloricdiet+MonCam, LED, HFCS20+Ex, catechin-rich green tea +inulin, VLCD, NPD+RT, Hyc+Ex, SD, Hyc+BWL, are the better treatments for weight loss in patients with overweight and obesity.


Assuntos
Obesidade , Sobrepeso , Dieta , Humanos , Metanálise em Rede , Obesidade/terapia , Perda de Peso
17.
Comput Math Methods Med ; 2021: 6730274, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34646336

RESUMO

Aim: The study is aimed at investigating the curative effect of acupuncture on simple obesity and its influence on serum levels of prostaglandin E and leptin in Sprague-Dawley (SD) rats. Methods: In the study, there are 50 male SD rats. We took 10 as healthy controls and fed 40 with a diet of high fat for 8 weeks. After the 40 rat model was established successfully, we fed 10 rats in the model group with a normal diet and treated 10 rats in the acupuncture group by acupuncture. During the experiment, the body fat and body length of rats were measured weekly, and Lee's index was calculated. After the treatment, the levels of leptin, prostaglandin E, C-reactive protein (CRP), triacylglycerol (TG), cholesterol (CHO), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were detected, and the liver fat morphology was observed by electron microscope. Results: Acupuncture significantly downregulated the serum levels of CRP, TG, CHO, LDL, leptin, and prostaglandin E and upregulated the serum levels of HDL in rats with simple obesity. Conclusion: On basis of these results, it was found that acupuncture could boost fat metabolism and weight loss by inhibiting the production of leptin and prostaglandin E.


Assuntos
Terapia por Acupuntura , Leptina/sangue , Obesidade/sangue , Obesidade/terapia , Prostaglandinas E/sangue , Tecido Adiposo/patologia , Animais , Proteína C-Reativa/metabolismo , Biologia Computacional , Modelos Animais de Doenças , Lipídeos/sangue , Fígado/patologia , Masculino , Obesidade/patologia , Ratos , Ratos Sprague-Dawley , Perda de Peso
18.
Blood Adv ; 5(21): 4447-4455, 2021 11 09.
Artigo em Inglês | MEDLINE | ID: mdl-34607345

RESUMO

Natural killer (NK) cells are a population of innate immune cells that can rapidly kill cancer cells and produce cytokines such as interferon-γ. A key feature of NK cells is their ability to respond without prior sensitization; however, it is now well established that NK cells can possess memory-like features. After activation with cytokines, NK cells demonstrate enhanced effector functions upon restimulation days or weeks later. This demonstrates that NK cells may be trained to be more effective killers and harnessed as more potent cancer immunotherapy agents. We have previously demonstrated that cellular metabolism is essential for NK cell responses, with NK cells upregulating both glycolysis and oxidative phosphorylation upon cytokine stimulation. Limiting NK cell metabolism results in reduced cytotoxicity and cytokine production. We have also demonstrated that defective NK cell responses in obesity are linked to defective cellular metabolism. In the current study, we investigated if cellular metabolism is required during the initial period of NK cell cytokine training and if NK cells from people with obesity (PWO) can be effectively trained. We show that increased flux through glycolysis and oxidative phosphorylation during the initial cytokine activation period is essential for NK cell training, as is the metabolic signaling factor Srebp. We show that NK cells from PWO, which are metabolically defective, display impaired NK cell training, which may have implications for immunotherapy in this particularly vulnerable group.


Assuntos
Interferon gama , Células Matadoras Naturais , Células Cultivadas , Citocinas , Humanos , Obesidade/terapia
19.
Clin Obes ; 11(6): e12482, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-34612589

RESUMO

Guidelines ask health professionals to offer brief advice to encourage weight loss for people living with obesity. We tested whether referral to one of three online programmes could lead to successful weight loss. A total of 528 participants aged ≥18 years with a body mass index of ≥30 kg/m2 were invited via a letter from their GP. Participants were randomised to one of three online weight loss programmes (NHS Weight Loss Plan, Rosemary Online or Slimming World Online) or to a control group receiving no intervention. Participants self-reported weight at baseline and 8 weeks. The primary outcome was weight change in each of the active intervention groups compared with control. We also compared the proportion of participants losing ≥5% or ≥10% of body weight. For Rosemary, Online mean weight loss was modestly greater than control (-1.5 kg [95% confidence interval (CI) -2.3 to -0.6]) and more than three times as many participants in this group lost ≥5% (relative risk [RR] = 3.64, 95% CI: 1.63-8.1). For Slimming World, mean weight loss was not significantly different from control (-0.8 kg [95%CI -1.7 to 0.1]), twice as many participants lost ≥5% (RR = 2.70, 1.17-6.23). There was no significant difference in weight loss for participants using the NHS Weight Loss Plan (-0.4 kg, [95% CI -1.3 to 0.5]), or the proportion losing ≥5% (RR = 2.09, 0.87-5.01). Only one of three online weight loss programmes was superior to no intervention and the effect size modest among participants living with obesity.


Assuntos
Perda de Peso , Programas de Redução de Peso , Adolescente , Adulto , Humanos , Obesidade/terapia , Atenção Primária à Saúde , Encaminhamento e Consulta
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