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4.
Ocul Immunol Inflamm ; 28(8): 1298-1300, 2020 Nov 16.
Artigo em Inglês | MEDLINE | ID: mdl-33021846

RESUMO

PURPOSE: To report a unique case of intraocular inflammation and outer retinal changes in a patient with coronavirus disease (COVID-19). CASE REPORT: A 57-year-old woman was seen 12 days after COVID-19 symptoms onset confirmed by positive IgM and IgG serological tests. No anterior chamber cells were seen. Color fundus photograph showed a yellowish lesion within the macular area, and fluorescein angiography revealed hyperfluorescence on the topography of the macular lesion in both eyes. Spectral-domain optical coherence tomography demonstrated hyperreflective pinpoints at the level of posterior vitreous hyaloid, corresponding to vitritis, hyperreflective lesions at the level of inner plexiform and ganglion cell layers, and disruption of the ellipsoid zone. CONCLUSION AND IMPORTANCE: COVID-19 is known to affect the inner retinal layers. The current case not only supports but also adds a vitreal and an outer retinal layer involvement that might also be caused by this infectious disease.


Assuntos
Betacoronavirus , Infecções por Coronavirus/complicações , Oftalmopatias/etiologia , Angiofluoresceinografia/métodos , Pneumonia Viral/complicações , Segmento Externo das Células Fotorreceptoras da Retina/patologia , Tomografia de Coerência Óptica/métodos , Corpo Vítreo/patologia , Infecções por Coronavirus/epidemiologia , Oftalmopatias/diagnóstico , Feminino , Fundo de Olho , Humanos , Pessoa de Meia-Idade , Pandemias , Pneumonia Viral/epidemiologia , Acuidade Visual
5.
PLoS One ; 15(9): e0238859, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32956371

RESUMO

OBJECTIVES: The aim of this study was to utilise corneal confocal microscopy to quantify corneal nerve morphology and establish the presence of sub-clinical small fibre damage and peripheral neuropathy in children with celiac disease. METHODS: This is a cross-sectional cohort study of twenty children with celiac disease and 20 healthy controls who underwent clinical and laboratory assessments and corneal confocal microscopy. Corneal nerve fiber density (no.mm2), corneal nerve branch density (no.mm2), corneal nerve fiber length (mm.mm2), corneal nerve fiber tortuosity and inferior whorl length (mm.mm2) were quantified manually. RESULTS: Corneal nerve fiber density (34.7±8.6 vs. 32.9±8.6; P = 0.5), corneal nerve branch density (47.2±24.5 vs. 47.3±20.0; P = 0.1) and corneal nerve fiber length (20.0±5.1 vs. 19.5±4.5; P = 0.8) did not differ between children with celiac disease and healthy controls. Corneal nerve fiber tortuosity (11.4±1.9 vs 13.5±3.0; P = 0.01) was significantly lower and inferior whorl length (20.0±5.5 vs 23.0±3.8; P = 0.06) showed a non-significant reduction in children with celiac disease compared to healthy controls. Inferior whorl length correlated significantly with corneal nerve fiber density (P = 0.005), corneal nerve branch density (P = 0.04), and corneal nerve fiber length (P = 0.002). CONCLUSION: Corneal confocal microscopy demonstrates minimal evidence of neuropathy in children with celiac disease.


Assuntos
Doença Celíaca/complicações , Córnea/patologia , Oftalmopatias/diagnóstico , Fibras Nervosas/patologia , Estudos de Casos e Controles , Criança , Estudos de Coortes , Córnea/inervação , Estudos Transversais , Oftalmopatias/diagnóstico por imagem , Oftalmopatias/etiologia , Feminino , Humanos , Processamento de Imagem Assistida por Computador/métodos , Masculino , Microscopia Confocal , Prognóstico
8.
J Med Internet Res ; 22(8): e20007, 2020 08 17.
Artigo em Inglês | MEDLINE | ID: mdl-32804086

RESUMO

BACKGROUND: Rapid access to evidence is crucial in times of an evolving clinical crisis. To that end, we propose a novel approach to answer clinical queries, termed rapid meta-analysis (RMA). Unlike traditional meta-analysis, RMA balances a quick time to production with reasonable data quality assurances, leveraging artificial intelligence (AI) to strike this balance. OBJECTIVE: We aimed to evaluate whether RMA can generate meaningful clinical insights, but crucially, in a much faster processing time than traditional meta-analysis, using a relevant, real-world example. METHODS: The development of our RMA approach was motivated by a currently relevant clinical question: is ocular toxicity and vision compromise a side effect of hydroxychloroquine therapy? At the time of designing this study, hydroxychloroquine was a leading candidate in the treatment of coronavirus disease (COVID-19). We then leveraged AI to pull and screen articles, automatically extract their results, review the studies, and analyze the data with standard statistical methods. RESULTS: By combining AI with human analysis in our RMA, we generated a meaningful, clinical result in less than 30 minutes. The RMA identified 11 studies considering ocular toxicity as a side effect of hydroxychloroquine and estimated the incidence to be 3.4% (95% CI 1.11%-9.96%). The heterogeneity across individual study findings was high, which should be taken into account in interpretation of the result. CONCLUSIONS: We demonstrate that a novel approach to meta-analysis using AI can generate meaningful clinical insights in a much shorter time period than traditional meta-analysis.


Assuntos
Inteligência Artificial , Infecções por Coronavirus/tratamento farmacológico , Oftalmopatias/etiologia , Hidroxicloroquina/efeitos adversos , Hidroxicloroquina/uso terapêutico , Metanálise como Assunto , Pneumonia Viral/tratamento farmacológico , Olho/efeitos dos fármacos , Olho/patologia , Humanos , Pandemias , Fatores de Tempo
10.
Medicine (Baltimore) ; 99(30): e21476, 2020 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-32791766

RESUMO

RATIONALE: Ocular siderosis is arrested by the removal of intraocular foreing body (IOFB). The progression of ocular siderosis is very rare and few reports demonstrate the optical coherence tomographic (OCT) findings. PATIENT CONCERNS: A 55-year-old Asian man presented to our clinic with the chief complaint of decreased vision in his left eye for 5 months. On slit lamp examination of the left eye, the corneal stroma had a rust-colored hue, and the retina was not visible due to vitreous opacity. An orbital computed tomography was ordered considering the possibility of left IOFB, which confirmed the presence of a vitreous IOFB. On the next day, he had a continuous curvilinear capsulorrhexis with phacoemulsification and intraocular lens implantation, pars plana vitrectomy, and removal of IOFB in the left eye. Six years later, he revisited our clinic. On slit lamp examination, the corneal haziness had worsened, and the iris showed heterochromia resembling the spokes of a wheel in the left eye. DIAGNOSIS: Ocular siderosis. INTERVENTION: Anterior and posterior segment OCT was performed. OUTCOMES: The anterior segment OCT showed linear hyperreflectivity on the anterior corneal stroma just beneath the Bowman's layer. The posterior segment OCT showed inner retinal degeneration observed at the parafoveal area. LESSONS: Ocular siderosis progression can happen after the removal of IOFB. The swept source OCT might be useful to assess the cornea and retina in ocular siderosis patient with corneal haziness.


Assuntos
Oftalmopatias/diagnóstico por imagem , Corpos Estranhos/complicações , Siderose/diagnóstico por imagem , Oftalmopatias/etiologia , Corpos Estranhos/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Siderose/etiologia , Tomografia de Coerência Óptica
11.
Clin Microbiol Infect ; 26(11): 1560.e5-1560.e8, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32835793

RESUMO

OBJECTIVES: To evaluate ocular symptoms in European non-hospitalized patients with severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) and to investigate associations with the demographic data as well as nasal and general physical symptoms. METHODS: In this prospective, observational study, 108 non-hospitalized patients with PCR-confirmed SARS-CoV-2 infection not requiring intensive care were asked about disease-associated ocular symptoms, demographic data, as well as general physical and nasal symptoms using a standardized questionnaire. Total ocular symptom score (TOSS) was evaluated during and, retrospectively, before development of coronavirus disease 2019 (COVID-19). Associations between TOSS and demographic data as well as general and nasal symptoms were evaluated. RESULTS: Seventy-five of the 108 COVID-19 patients (69.4%) had at least one ocular symptom during COVID-19. The most common symptoms included burning sensations in 39 (36.1%), epiphora in 37 (34.3%) and redness in 28 (25.9%), compatible with conjunctivitis. These symptoms occurred 1.96 ± 3.17 days after the beginning of COVID-19 and were mild. TOSS was significantly higher during COVID-19 (1.27 ± 1.85) than before the infection (0.33 ± 1.04; p < 0.001). There were no significant associations between TOSS and gender (ß coefficient -0.108; p 0.302), age (-0.024; p 0.816), rhinorrhoea (-0.127; p 0.353), nasal itching (-0.026; p 0.803), sneezing (0.099; p 0.470), nasal congestion (-0.012; p 0.930), cough (-0.079; p 0.450), headache (0.102; p 0.325), sore throat (0.208; p 0.052), or fever (0.094; p 0.361). CONCLUSIONS: Ocular involvement in European non-hospitalized individuals with COVID-19 seems to be highly underestimated. Overall, these ocular symptoms, including burning sensations, epiphora and redness, seem to be mild and to not need treatment.


Assuntos
Infecções por Coronavirus/complicações , Oftalmopatias/etiologia , Oftalmopatias/patologia , Pneumonia Viral/complicações , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Betacoronavirus , Infecções por Coronavirus/epidemiologia , Infecções por Coronavirus/patologia , Europa (Continente)/epidemiologia , Oftalmopatias/epidemiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pandemias , Pneumonia Viral/epidemiologia , Pneumonia Viral/patologia , Prevalência , Estudos Prospectivos , Adulto Jovem
12.
JAMA Ophthalmol ; 138(10): 1079-1086, 2020 10 01.
Artigo em Inglês | MEDLINE | ID: mdl-32845280

RESUMO

Importance: Ocular manifestations and outcomes in children with confirmed coronavirus disease 2019 (COVID-19), relevant affecting factors, and differences in ocular disease between children and adults have yet to be fully understood. Objective: To investigate ocular manifestations and clinical characteristics of children with laboratory-confirmed COVID-19. Design, Setting, and Participants: This cross-sectional study was conducted at Wuhan Children's Hospital in Wuhan, China. Children with COVID-19 confirmed by severe acute respiratory syndrome coronavirus disease 2 nucleic acid tests of upper respiratory tract specimens between January 26 and March 18, 2020, were included. Main Outcomes and Measures: Onset clinical symptoms and duration, ocular symptoms, and needs for medication. Results: A total of 216 pediatric patients were included, among whom 134 (62%) were boys, with a median (interquartile range) age of 7.25 (2.6-11.6) years. Based on the exposure history, 193 children (89.4%) had a confirmed (173 [80.1%]) or suspected (20 [9.3%]) family member with COVID-19 infection. The most common symptoms among symptomatic children were fever (81 [37.5%]) and cough (79 [36.6%]). Of 216 children, 93 (43.1%) had no systemic or respiratory symptoms. All children with mild (101 [46.8%]) or moderate (115 [53.2%]) symptoms recovered without reported death. Forty-nine children (22.7%) showed various ocular manifestations, of which 9 had ocular complaints being the initial manifestations of COVID-19. The common ocular manifestations were conjunctival discharge (27 [55.1%]), eye rubbing (19 [38.8%]), and conjunctival congestion (5 [10.2%]). Children with systemic symptoms (29.3% vs 14.0%; difference, 15.3%; 95% CI, 9.8%-20.7%; P = .008) or with cough (31.6% vs 17.5%; difference, 14.1%; 95% CI, 8.0%-20.3%; P = .02) were more likely to develop ocular symptoms. Ocular symptoms were typically mild, and children recovered or improved. Conclusions and Relevance: In this cross-sectional study, children hospitalized with COVID-19 in Wuhan, China, presented with a series of onset symptoms including fever, cough, and ocular manifestations, such as conjunctival discharge, eye rubbing, and conjunctival congestion. Patients' systemic clinical symptoms or cough were associated with ocular symptoms. Ocular symptoms recovered or improved eventually.


Assuntos
Betacoronavirus , Infecções por Coronavirus/complicações , Oftalmopatias/etiologia , Pneumonia Viral/complicações , Adolescente , Criança , Pré-Escolar , Estudos Transversais , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Pandemias
13.
Fontilles, Rev. leprol ; 32(5): 303-317, mayo-ago. 2020. tab, graf, ilus
Artigo em Espanhol | IBECS | ID: ibc-198458

RESUMO

OBJETIVO: identificar las afecciones oculares diagnosticadas en los pacientes con Lepra que asistieron a consulta oftalmológica en el servicio de Uveitis e Inflamaciones Oculares (SUIO) del Instituto Cubano de Oftalmología Ramon Pando Ferrer en el periodo 2017-2019. MÉTODOS: se realizó un estudio descriptivo prospectivo observacional en pacientes con diagnóstico de lepra quienes cumplieron los criterios de inclusión y exclusión de la investigación. Las variables estudiadas fueron: edad, sexo, afecciones oftalmológicas y grado de discapacidad. RESULTADOS: predomino el sexo masculino y el grupo de edad entre 45-59 años, la mayoría de los pacientes se diagnosticaron tardíamente después del ano del comienzo de los síntomas, las afecciones oculares predominaron en el segmento anterior del ojo y se diagnosticaron cuatro pacientes con diferentes grados de discapacidad ocular. CONCLUSIONES: las afecciones oculares del segmento anterior son frecuentes en los pacientes con lepra, sobre todo en las formas lepromatosas y pueden aparecer en el momento del diagnóstico, durante o después del tratamiento. Muchas de las causas de afecciones oculares en los pacientes con lepra son prevenibles, es primordial garantizar la asistencia oftalmológica en los mismos


OBJECTIVE: to identify the ocular affections in patient with a diagnosis of leprosy in the department of Uveitis and Ocular (SUIO) Inflammations of the Cuban Institute of Ophthalmology Ramon Pando Ferrer during the period 2017-2019. METHODS: a prospective observational descriptive study in patients with diagnosis of leprosy who completed the admission or exclusion criteria of the investigation was carried out. The studied variables were age, sex, ophthalmological affections and grade of incapacity. RESULTS: The male gender and the age group among 45-59 years prevailed. Most of the patients were diagnosed belatedly after the year of the beginning of the symptoms, the ocular affections prevailed in the segment previous of the eye, and four patients were diagnosed with different grades of ocular discapacity. CONCLUSIONS: the ocular affections of the previous segment are frequent in the patients with leprosy, mainly in the lepromatous type of the disease and they can appear during the presentation of the patient and diagnosis or during or after the treatment. Many of the causes of ocular affections in the patients with leprosy can be prevented and the required ophthalmological care to avoid them must be provided


Assuntos
Humanos , Masculino , Feminino , Lactente , Pré-Escolar , Criança , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Idoso , Hanseníase/complicações , Oftalmopatias/etiologia , Oftalmopatias/epidemiologia , Hanseníase/epidemiologia , Estudos Prospectivos , Distribuição por Idade e Sexo , Hanseníase/patologia , Índice de Gravidade de Doença , Cuba/epidemiologia
14.
PLoS One ; 15(7): e0234818, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32663210

RESUMO

BACKGROUND: Erlotinib is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors used to treat EGFR mutation positive non-small-cell lung cancer (NSCLC). Skin rash and diarrhea are well-known and common adverse events in patients receiving erlotinib, whereas other adverse events, including eye, liver, or renal disorders have not been evaluated adequately. This meta-analysis aimed to evaluate the ocular, hepatobiliary, and renal toxicities of erlotinib in patients with NSCLC cancers. METHODS: In total, sixty studies were assessed, and the results of the included studies were quantitatively integrated using meta-analysis. The incidence of ocular, hepatobiliary (alanine aminotransferase [ALT] and bilirubin elevations; other hepatic adverse events), and renal adverse events were estimated. Additionally, the erlotinib-treated groups and the control groups (placebo or other treatment) were compared with respect to ocular disorders and ALT elevation. The study protocol has been registered in the International Prospective Register for Systematic Reviews (PROSPERO) CRD42018093758. RESULTS: The overall incidence of ocular disorders was 3.30% (95% confidence interval [CI] 2.20%-5.00%). The incidence of ALT elevation, bilirubin elevation, and other hepatobiliary disorders was 6.40% (95% CI 3.90%-10.4%), 3.80% (95% CI 2.30%-6.10%), and 1.00% (95% 0.60%-1.80%), respectively. The incidence of renal disorder was 3.10% (95% CI 1.90%-5.00%). The risk of ocular toxicity in the erlotinib treatment group was significantly increased (risk ratio = 2.91; 95% CI 1.70-4.98) compared to that in the control group. ALT elevation was not significantly different between the two groups. CONCLUSION: Based on the results, careful monitoring of ocular toxicity in patients receiving erlotinib should be recommended and closer monitoring of hepatic toxicity should be also recommended in patients with liver-related risk factors.


Assuntos
Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico , Carcinoma Pulmonar de Células não Pequenas/fisiopatologia , Cloridrato de Erlotinib/efeitos adversos , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Doenças do Sistema Digestório/etiologia , Intervalo Livre de Doença , Receptores ErbB/genética , Cloridrato de Erlotinib/uso terapêutico , Exantema/etiologia , Olho/efeitos dos fármacos , Oftalmopatias/etiologia , Feminino , Trato Gastrointestinal/efeitos dos fármacos , Humanos , Rim/efeitos dos fármacos , Nefropatias/etiologia , Neoplasias Pulmonares/genética , Masculino , Mutação , Inibidores de Proteínas Quinases/uso terapêutico
16.
Middle East Afr J Ophthalmol ; 27(1): 62-64, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32549728

RESUMO

Vitreous cysts are a rare finding and rarely cause any visual disturbances. They are often classified as idiopathic when their etiology cannot be determined. They may be congenital or acquired and pigmented or nonpigmented. In previous reports, it has been suggested on the basis of electron microscopy that these pigmented vitreous cysts may have originated from the pigment epithelium. We present the case of a 46-year-old female, with complaints of an oval-shaped floater, causing some visual disturbance in her right eye. On examination, it was found to be a pigmented, round, and nonlobulated cyst floating freely in the vitreous cavity with no attachments to the retina. This was documented and confirmed by the fundus images and optical coherence tomography findings. Laboratory tests in the patient were found to be negative for any Toxoplasma, cysticercoids, Echinococcus, and Toxocara, among others. She was on follow-up for the past 6 months with no change or disturbance in the cyst or the retinal findings. We describe a rare case of idiopathic pigmented vitreous cyst with no persistent hyaloid artery or connection between the cyst and the ocular structures.


Assuntos
Cistos/etiologia , Oftalmopatias/etiologia , Corpo Vítreo/patologia , Cistos/diagnóstico por imagem , Oftalmopatias/diagnóstico por imagem , Feminino , Fundo de Olho , Humanos , Pessoa de Meia-Idade , Tomografia de Coerência Óptica , Ultrassonografia , Transtornos da Visão/etiologia , Corpo Vítreo/diagnóstico por imagem
17.
Ann Agric Environ Med ; 27(2): 165-170, 2020 Jun 19.
Artigo em Inglês | MEDLINE | ID: mdl-32588588

RESUMO

INTRODUCTION: SARS-CoV-2 (severe acute respiratory syndrome-coronavirus-2) is a coronavirus that causes COVID-19 (coronavirus disease 2019) with mild to severe respiratory illness. It is a highly contagious disease transmitted through direct or indirect contact with infected people or contaminated surfaces, mainly through respiratory droplets, but other routes are being investigated. OBJECTIVE: It is known that coronaviruses (CoVs) can cause a variety of ocular pathologies in animals, including conjunctivitis, anterior uveitis, retinitis, and optic neuritis, many of which are severe. However, there is no evidence of the SARS-CoV-2 presence in the eye tissue of asymptomatic patients, even if the symptomatic incidence is low. This systematic review presents updated literature on this issue. ABBREVIATED DESCRIPTION OF THE STATE OF KNOWLEDGE: COVID-19 has now spread throughout the continents and poses a global threat to public health. The risk of rapidly overloading health care systems and causing substantial mortality worldwide is real. On 11 March 2020, the World Health Organization (WHO) announced coronavirus as a global pandemic. Several studies described a few cases with initial ocular symptoms followed by systemic symptoms of the disease. SUMMARY: Although the frequency of transmission of SARS-CoV-2 infection through the eye is low, ocular symptoms are not uncommon in COVID-19. In some cases, eye symptoms may be the first signs of illness. This implies the need for hygienic recommendations and use of personal protective equipment (PPE) for medical staff and other services to minimize COVID-19 infection of both health-care workers and patients. A triage for ophthalmic outpatient clinic is mandatory.


Assuntos
Betacoronavirus , Infecções por Coronavirus/complicações , Oftalmopatias/etiologia , Oftalmopatias/virologia , Pneumonia Viral/complicações , Infecções por Coronavirus/transmissão , Oftalmopatias/patologia , Oftalmopatias/prevenção & controle , Pessoal de Saúde , Humanos , Pandemias , Pneumonia Viral/transmissão
18.
In Vivo ; 34(3 Suppl): 1619-1628, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32503820

RESUMO

The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in China in the city of Wuhan in December of 2019 and since then more than 5,000,000 people have been infected, with approximately 338,000 deaths worldwide. The virus causes the coronavirus disease 2019 (COVID-19), which is characterized by fever, myalgia and cough, with severe acute respiratory syndrome being the most fearsome complication. Nevertheless, the vast majority of cases present mild symptoms or none. Central nervous system and cardiovascular manifestations have been reported. The range of ocular manifestations, either as a result of the infection or as a result of the treatment, has not yet been discussed. In this study, a systematic review of current literature relevant to COVID-19 was performed with focus on modes of transmission, ocular manifestations related to infection and medications, as well as the control of infection in ophthalmic practice.


Assuntos
Infecções por Coronavirus/complicações , Oftalmopatias/etiologia , Pneumonia Viral/complicações , Doenças do Nervo Abducente/etiologia , Antivirais/efeitos adversos , Antivirais/uso terapêutico , Betacoronavirus/fisiologia , Biomarcadores , China , Doenças da Túnica Conjuntiva/sangue , Doenças da Túnica Conjuntiva/etiologia , Lentes de Contato/efeitos adversos , Infecções por Coronavirus/tratamento farmacológico , Infecções por Coronavirus/terapia , Infecções por Coronavirus/transmissão , Contaminação de Equipamentos , Oftalmopatias/prevenção & controle , Humanos , Hiperemia/sangue , Hiperemia/etiologia , Imunização Passiva/efeitos adversos , Transmissão de Doença Infecciosa do Paciente para o Profissional/prevenção & controle , Ceratoconjuntivite/etiologia , Doenças do Aparelho Lacrimal/sangue , Doenças do Aparelho Lacrimal/etiologia , Contagem de Leucócitos , Pandemias , Pneumonia Viral/tratamento farmacológico , Pneumonia Viral/transmissão , Doenças Retinianas/induzido quimicamente , Estudos Retrospectivos
19.
Rev. cuba. oftalmol ; 33(2): e943,
Artigo em Espanhol | LILACS, CUMED | ID: biblio-1139077

RESUMO

RESUMEN La Organización Mundial de la Salud declaró el 11 de marzo del año 2020 pandemia por la COVID-19, enfermedad causada por el SAR-COV-2. Al no existir medicamentos efectivos disponibles para esta infección viral, muchos han sido los esfuerzos de las políticas de salud para lograr un control adecuado de la fuente de infección, la transmisión y la protección en poblaciones susceptible, mediante las cuarentenas obligatorias como medida oportuna de prevención. Hasta el momento la presencia de conjuntivitis viral y el riesgo de contagio por vía ocular son datos mencionados en la literatura internacional en el curso de diversas investigaciones. Se conoce que el virus puede aislarse en la lágrima y en la conjuntiva, y que su transmisibilidad por las secreciones oculares es posible. La actual pandemia del coronavirus es una emergencia sanitaria mundial y muchos países han sido actualmente afectados con miles de fallecidos. Se realizó una búsqueda de diversos artículos publicados, con el objetivo de conocer las manifestaciones oculares de la COVID-19 reportadas por diferentes investigadores. Se utilizó la plataforma Infomed, específicamente la Biblioteca Virtual de Salud(AU)


ABSTRACT COVID-19, a disease caused by SARS-CoV-2, was declared pandemic by the World Health Organization on 11 March 2020. In the absence of effective medications for this viral infection, many have been the efforts made by health policies to adequately control the source of infection and transmission, and to protect susceptible populations through compulsory quarantine as a timely prevention measure. Viral conjunctivitis and risk of contagion via the ocular route have been mentioned in a variety of international studies contained in the bibliography about the topic. It has been found that the virus may be isolated from tears and from the conjunctiva, and that it may be transmitted via ocular secretion. The current coronavirus pandemic is a world health emergency causing thousands of deaths in many countries. A search was conducted for published papers to identify the ocular manifestations of COVID-19 reported by researchers. Use was made of the platform Infomed, specifically the Virtual Health Library(AU)


Assuntos
Humanos , Conjuntivite Viral , Infecções por Coronavirus/epidemiologia , Oftalmopatias/etiologia , Literatura de Revisão como Assunto
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