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3.
J Vet Diagn Invest ; 32(2): 282-286, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31955669

RESUMO

Clostridium perfringens type D epsilon toxin (EXT) causes an important neurologic disorder of sheep, goats and, rarely, cattle. The disease can occur in peracute, acute, subacute, and chronic forms. High circulating levels of ETX produce vasculocentric brain lesions, in which microvascular endothelial injury results in diagnostically useful perivascular and intramural extravasations of plasma protein, especially in sheep, and less frequently in goats. With lower toxin doses, a more protracted clinical course tends to occur, particularly in sheep, leading to focal, bilaterally symmetrical, necrotic foci in certain brain regions. Although these morphologic features usually permit the diagnostic pathologist to make a definitive etiologic diagnosis, there are many aspects of the pathogenesis of these cerebral lesions that are not completely understood. ETX has also been shown to produce microvascular damage in the retina of rats, resulting in severe, diffuse vasogenic edema, similar to that found in brains exposed to this neurotoxin. The pathoclisis and vascular theories offer alternative explanations of the differential susceptibility of different brain regions to the same neurotoxic insult.


Assuntos
Toxinas Bacterianas/toxicidade , Encefalopatias/veterinária , Infecções por Clostridium/veterinária , Clostridium perfringens/fisiologia , Clostridium perfringens/patogenicidade , Oftalmopatias/veterinária , Encefalopatias/diagnóstico , Encefalopatias/microbiologia , Encefalopatias/patologia , Infecções por Clostridium/microbiologia , Infecções por Clostridium/patologia , Oftalmopatias/diagnóstico , Oftalmopatias/microbiologia , Oftalmopatias/patologia , Virulência
4.
J Biosci ; 44(5)2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31719219

RESUMO

Implicating dysbiosis of gut microbiome in digestive tract diseases/diet-related diseases (obesity, inflammatory bowel disease, enterocolitis, diabetes, etc.) may be expected. However, when gut microbiome dysbiosis is implicated in extraintestinal diseases like cancers, muscular dystrophy, mental disorders, vaginosis, etc., it is all the more challenging. An additional challenge would be to ascertain the role of gut microbiome in ocular diseases, which are as remote as the brain. The present review highlights studies that establish the connect between gut microbiome dysbiosis and inflammatory ocular diseases such as uveitis, bacterial keratitis, fungal keratitis, etc.


Assuntos
Oftalmopatias/microbiologia , Microbioma Gastrointestinal , Humanos
5.
J Aquat Anim Health ; 31(4): 354-363, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31765509

RESUMO

The order Saprolegniales (Class Oomycota) is a group of fungus-like eukaryotic microorganisms that have been associated with infections in fish and fish eggs. Infections with microorganisms from this order are clearly evident because they have a cotton wool-like appearance. The aim of this study was to characterize and identify an oomycete that was isolated from the eye of an Orange Blotched Peacock Cichlid Aulonacara sp. A sample of cotton wool-like mycelia was isolated and single-spore isolations were conducted. Molecular characterization and phylogenetic analysis of the ITS1-5.8-ITS2 rDNA region for all isolates were used for species identification. Following molecular identification, one isolate was used to culture and characterize the reproductive structures. Physiological characterization entailed incubating the isolate on potato dextrose agar (PDA) at five different temperatures, ranging from 5°C to 25°C, to monitor growth rates. A multiple sequence alignment showed 100% similarity between all of the single-spore isolates and alignment with other Achlya bisexualis strains. Long, coarse hyphae with zoosporangia and gemmae typical of the order Saprolegniales were observed with an optimal growth rate at 25°C. The oomycete that was isolated from an Orange Blotched Peacock Cichlid was identified as A. bisexualis, the first record of this species in South Africa.


Assuntos
Ciclídeos , Oftalmopatias/veterinária , Doenças dos Peixes/microbiologia , Infecções/veterinária , Saprolegnia/fisiologia , Animais , Oftalmopatias/microbiologia , Infecções/microbiologia , Saprolegnia/classificação , África do Sul
6.
BMC Neurol ; 19(1): 243, 2019 Oct 21.
Artigo em Inglês | MEDLINE | ID: mdl-31638926

RESUMO

BACKGROUND: Nocardiosis is a rare and life-threatening opportunistic infection in immunocompromised patients. Myasthenia gravis (MG) patients are potentially at risk of nocardia infection because of the use of immunosuppressive agents. To date, only 7 patients with MG have been reported to have nocardiosis. Disseminated nocardiosis with ocular involvement has not been reported in MG patients. CASE PRESENTATION: A 66-year-old man with MG who was receiving treatment with methylprednisolone and azathioprine was found to have a respiratory infection. He also had heterogeneous symptoms with skin, brain and ocular manifestations. Nocardia bacteria verified by the culture of puncture fluid, and a diagnosis of disseminated nocardiosis was made. Except for left eye blindness, the patient completely recovered from the disease with combination antibiotic therapy. To further understand nocardiosis in patients with MG, we reviewed the previous relevant literature. According to the literature, this is the first report of disseminated nocardiosis with ocular involvement in an MG patient. CONCLUSIONS: MG patients with immunosuppressant treatments are potentially at risk of a rare nocardia infection, and a favourable prognosis can be achieved through early diagnosis and appropriate antibiotic therapy.


Assuntos
Hospedeiro Imunocomprometido , Miastenia Gravis/imunologia , Nocardiose/imunologia , Idoso , Antibacterianos/uso terapêutico , Oftalmopatias/microbiologia , Humanos , Imunossupressores/administração & dosagem , Masculino , Miastenia Gravis/complicações , Miastenia Gravis/tratamento farmacológico , Nocardia , Nocardiose/tratamento farmacológico , Nocardiose/patologia
7.
Microbiologyopen ; 8(10): e906, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31389671

RESUMO

Epidemiological studies comparing clinical and commensal Staphylococcus epidermidis isolates suggest that biofilm formation is a discriminant biomarker. A study showed that four non-biofilm-forming clinical S. epidermidis isolates could form an induced biofilm by trypsin treatment, suggesting that S. epidermidis can form biofilms in a protease-independent way and in a trypsin-induced way. In this study, the trypsin capacity to induce biofilm formation was evaluated in non-biofilm-forming S. epidermidis isolates (n = 133) in order to support this mechanism and to establish the importance of total biofilms (meaning the sum of protease-independent biofilm and trypsin-induced biofilm). Staphylococcus epidermidis isolates from ocular infections (OI; n = 24), prosthetic joint infections (PJI; n = 64), and healthy skin (HS-1; n = 100) were screened for protease-independent biofilm formation according to Christensen's method. The result was that there are significant differences (p < .0001) between clinical (43.2%) and commensal (17%) protease-independent biofilm producers. Meanwhile, non-biofilm-forming isolates were treated with trypsin, and biofilm formation was evaluated by the same method. The number of commensal trypsin-induced biofilm producers significantly increased from 17% to 79%. In contrast, clinical isolates increased from 43.2% to 72.7%. The comparison between clinical and commensal total biofilm yielded no significant differences (p = .392). A similar result was found when different isolation sources were compared (OI vs. HS-1 and PJI vs. HS-1). The genotype icaA- /aap+ was associated with the trypsin-induced biofilm phenotype; however, no correlation was observed between aap mRNA expression and the level of trypsin-induced biofilm phenotype. Studying another group of commensal S. epidermidis non-biofilm-forming isolates (HS-2; n = 139) from different body sites, it was found that 70 isolates (60.3%) formed trypsin-induced biofilms. In conclusion, trypsin is capable of inducing biofilm production in non-biofilm-forming commensal S. epidermidis isolates with the icaA- /aap+ genotype, and there is no significant difference in total biofilms when comparing clinical and commensal isolates, suggesting that total biofilms are not a discriminant biomarker.


Assuntos
Biofilmes/efeitos dos fármacos , Biofilmes/crescimento & desenvolvimento , Staphylococcus epidermidis/efeitos dos fármacos , Staphylococcus epidermidis/crescimento & desenvolvimento , Tripsina/metabolismo , Proteínas de Bactérias/genética , Oftalmopatias/microbiologia , Perfilação da Expressão Gênica , Genótipo , Voluntários Saudáveis , Humanos , Osteoartrite/microbiologia , Infecções Relacionadas à Prótese/microbiologia , Pele/microbiologia , Infecções Estafilocócicas/microbiologia , Staphylococcus epidermidis/genética , Staphylococcus epidermidis/isolamento & purificação
8.
Fontilles, Rev. leprol ; 32(2): 75-85, mayo-ago. 2019. ilus
Artigo em Espanhol | IBECS | ID: ibc-187211

RESUMO

La detección temprana y tratamiento de las afecciones oculares en pacientes con enfermedad de Hansen es muy importante ya que generalmente tienen un carácter crónico y son de difícil manejo pudiendo llevar al paciente a la disminución de la visión y/o ceguera. Las inflamaciones intraoculares se encuentran entre las complicaciones oculares que pueden presentarse en estos pacientes (4.6%). Se presenta un caso de una paciente femenina de raza negra de 42 años con diagnóstico de enfermedad de Hansen desde el año 2015 (Lepra Lepromatosa) llevando tratamiento completo con multidrogas durante un año. Se remite al servicio de Uveítis del Instituto Oftalmológico Ramón Pando Ferrer, diagnosticándose una panuveítis bilateral granulomatosa. Se indicó tratamiento intensivo con midriáticos, esteroides tópicos y en alta dosis por vía oral, con reducción progresiva de los mismos, logrando el control de su enfermedad ocular y mejoría de la agudeza visual. Las características de este tipo de paciente requieren una valoración personalizada. Por esto se presenta su manejo clínico y evolución


The early detection and treatment of ocular affections in patients with Hansen’s disease is very important since they are usually of a chronic nature, they are difficult to manage and may lead the patient to decreased vision and/or blindness. Intraocular inflammations are among the ocular complications that can occur in these patients (4.6%). We describe a case of a 42-year-old black female patient diagnosed with Hansen’s disease since 2015 (Leprosy Leprosy) taking complete treatment with multidrug therapy for one year. She referred to the Uveitis Department of the Ramón Pando Ferrer Ophthalmological Institute and was diagnosed of a bilateral granulomatous panuveitis. Intensive treatment was indicated with mydriatics, topical and high oral doses of steroids. A progressive reduction of them, achieved control of the ocular disease and improvement of visual acuity. The characteristics of this type of patient require a personalized assessment. This is why we present its clinical management and evolution


Assuntos
Humanos , Feminino , Adulto , Hanseníase Virchowiana/complicações , Hanseníase Virchowiana/diagnóstico por imagem , Oftalmopatias/diagnóstico , Oftalmopatias/microbiologia , Tomografia de Coerência Óptica , Angiofluoresceinografia
9.
Curr Opin Allergy Clin Immunol ; 19(5): 482-487, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31169596

RESUMO

PURPOSE OF REVIEW: The purpose of this review is to provide an update regarding new and emerging data on the role of the ocular surface microbiome in allergic disease. RECENT FINDINGS: Recent findings support the role of the microbiome in the pathophysiology of allergic disease of the ocular surface. SUMMARY: Understanding the role of the ocular surface microbiome in allergic disease may provide a new target for the development of therapeutic interventions.


Assuntos
Oftalmopatias , Olho , Hipersensibilidade , Microbiota/imunologia , Olho/imunologia , Olho/microbiologia , Oftalmopatias/imunologia , Oftalmopatias/microbiologia , Oftalmopatias/terapia , Humanos , Hipersensibilidade/imunologia , Hipersensibilidade/microbiologia , Hipersensibilidade/terapia
10.
Vet Pathol ; 56(5): 749-760, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31132943

RESUMO

This study describes clinical and histopathological features, treatment, and outcome of cats diagnosed with ocular mycobacteriosis. Cases diagnosed from 2012 to 2017 were reviewed for (a) histopathological evidence of ocular (pyo)granulomatous inflammation containing acid-fast bacilli with mycobacterial morphology, (b) positive mycobacterial culture and/or mycobacterial DNA identified by polymerase chain reaction of ocular tissue, or (c) presumed mycobacteriosis based on ophthalmic examination and positive interferon-gamma release assay. Twenty-five cats (31 eyes) were included; 14 cats (17/31 eyes, 55%) were blind at presentation (unilateral: n = 12 cats; bilateral: n = 2 cats); one unilaterally affected cat later became bilaterally blind. Another 5 cats (7/31 eyes, 23%) became blind after initially being bilaterally visual (unilateral: n = 3 cats; bilateral: n = 2 cats). The commonest ocular finding was uveitis (87%). The main histopathological features were granulomatous to pyogranulomatous chorioretinitis with retinal detachment, anterior uveitis, optic neuritis, episcleritis, scleritis, and/or retrobulbar cellulitis. Nineteen cats (76%) had systemic signs, with disseminated disease being diagnosed in 9, defined by interstitial pulmonary disease, generalized lymphadenopathy, and/or nonocular infection. Nine cats were diagnosed with Mycobacterium bovis, 2 with Mycobacterium microti, 1 with Mycobacterium tuberculosis complex, and 1 with Mycobacterium avium-intracellulare complex. The infecting species was unknown in the remaining cats. Combined surgery (enucleation: n = 5 cats; biopsy: n = 3 cats) and systemic treatment with 2 or 3 appropriate antibiotics for 2 to 7 months resulted in remission in 8 of the 10 cats treated; however, the cat treated with dual therapy relapsed after 8 months. A total of 16 cats (64%) were euthanized; 2 were lost to follow-up.


Assuntos
Doenças do Gato/microbiologia , Oftalmopatias/veterinária , Infecções por Mycobacterium/veterinária , Mycobacterium/isolamento & purificação , Animais , Antibacterianos/uso terapêutico , Doenças do Gato/patologia , Doenças do Gato/terapia , Gatos , Oftalmopatias/microbiologia , Mycobacterium/classificação , Infecções por Mycobacterium/microbiologia , Infecções por Mycobacterium/terapia , Estudos Retrospectivos , Resultado do Tratamento
11.
Ocul Surf ; 17(3): 384-392, 2019 07.
Artigo em Inglês | MEDLINE | ID: mdl-31125783

RESUMO

The microbiome is important to the host as a whole, both in maintenance of health and in the pathophysiology of disease. The purpose of this review is to explore the relationship between the gut, ocular microbiome, and ocular disease states. We will also discuss how the microbiome can serve as a potential target for treatment, by methods such as modulation of diet, probiotics and fecal microbiota transplantation. The information discussed in the review has been gathered using literature published from 2004 to November 2018, as indexed in PubMed.


Assuntos
Oftalmopatias/terapia , Microbiota/fisiologia , Probióticos/uso terapêutico , Oftalmopatias/microbiologia , Humanos
14.
Arch. Soc. Esp. Oftalmol ; 94(2): 55-59, feb. 2019. graf, tab
Artigo em Espanhol | IBECS | ID: ibc-180366

RESUMO

Objetivo: Determinar la microbiota en teléfonos móviles utilizados durante la consulta oftalmológica por parte del personal médico, de los pacientes y de los familiares. Métodos: Se analizaron los teléfonos celulares del personal médico y de los pacientes y/o los familiares en el área de consulta de la especialidad. Se realizó una encuesta para evaluar el patrón de uso y la desinfección de los teléfonos móviles. Se tomó una muestra de raspado de los celulares. Las muestras obtenidas fueron inoculadas en medios de cultivo y se incubaron a 37 °C durante 24 h. Se identificó género y especie en los cultivos positivos y se analizaron los resultados obtenidos utilizando estadística descriptiva. Resultados: Se analizaron 71 teléfonos celulares del personal médico y 52 de los pacientes y/o los familiares. Los microorganismos aislados en los teléfonos celulares de los médicos oftalmólogos fueron: estafilococos coagulasa negativa (ECN) 50%, Staphylococcus aureus 32,4%, enterobacterias 4,2%, actinomicetos 4,2 y 9,8% resultaron negativos. Por otro lado, en los teléfonos celulares de los pacientes y los familiares, los microorganismos aislados fueron Staphylococcus aureus 75%, estafilococos coagulasa negativa (ECN) 24% y enterobacterias 1%. Conclusiones: Los resultados obtenidos muestran que los teléfonos celulares, tanto del personal médico como de los pacientes y sus familiares, contienen bacterias consideradas patógenas que podrían establecer una infección. Es relevante establecer una práctica rutinaria de limpieza del teléfono celular y concienciar a la población de los hábitos de higiene, puesto que en ellos queda el cuidado de sus ojos después de la consulta


Objective: To determine the microbiota of mobile phones used during the ophthalmological consultation by medical personnel, patients, and family members. Methods: An analysis was made on the mobile phones of the medical staff and of patients and/or family members in the area of clinical specialty. A survey was conducted to evaluate the pattern of use and disinfection of mobile phones. A smear sample was taken from the mobile phones. The specimens obtained were inoculated in culture media and incubated at 37 °C for 24 hours. Genus and species were identified in the positive cultures and the results obtained were analysed using descriptive statistics. Results: An analysis was made on 71 mobile phones of medical personnel and 52 from patients and/or family members. The microorganisms isolated in the mobile phones of the ophthalmologists were: coagulase-negative staphylococci 50%, Staphylococcus aureus 32.4%, enterobacteria 4.2%, Actinomycetes 4.2%, and 9.8% were negative. On the other hand, in the phones of patients and relatives, the isolated microorganisms were Staphylococcus aureus 75%, coagulase-negative staphylococci 24%, and enterobacteria 1%. Conclusions: The results obtained show that mobile phones, both of the medical staff and of the patients and their relatives, contain bacteria considered pathogenic that could cause an infection. It is important to establish a routine practice of cleaning mobile phones and to make the population aware of hygiene habits, since they are responsible for the care of their eyes after consultation


Assuntos
Humanos , Microbiota , Telefone Celular , Oftalmopatias/epidemiologia , Corpo Clínico , Pacientes/estatística & dados numéricos , Farmacorresistência Bacteriana , Meios de Cultura/isolamento & purificação , Staphylococcus aureus/isolamento & purificação , Coagulase/análise , Enterobacteriaceae/isolamento & purificação , Estudos Prospectivos , Estudos Transversais , Inquéritos e Questionários , Higiene , Desinfecção/métodos , Oftalmopatias/microbiologia
15.
PLoS One ; 14(1): e0210245, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30615687

RESUMO

Chlamydia pecorum is responsible for causing ocular infection and disease which can lead to blindness in koalas (Phascolarctos cinereus). Antibiotics are the current treatment for chlamydial infection and disease in koalas, however, they can be detrimental for the koala's gastrointestinal tract microbiota and in severe cases, can lead to dysbiosis and death. In this study, we evaluated the therapeutic effects provided by a recombinant chlamydial major outer membrane protein (MOMP) vaccine on ocular disease in koalas. Koalas with ocular disease (unilateral or bilateral) were vaccinated and assessed for six weeks, evaluating any changes to the conjunctival tissue and discharge. Samples were collected pre- and post-vaccination to evaluate both humoral and cell-mediated immune responses. We further assessed the infecting C. pecorum genotype, host MHC class II alleles and presence of koala retrovirus type (KoRV-B). Our results clearly showed an improvement in the clinical ocular disease state of all seven koalas, post-vaccination. We observed increases in ocular mucosal IgA antibodies to whole C. pecorum elementary bodies, post-vaccination. We found that systemic cell-mediated immune responses to interferon-γ, interleukin-6 and interleukin-17A were not significantly predictive of ocular disease in koalas. Interestingly, one koala did not have as positive a clinical response (in one eye primarily) and this koala was infected with a C. pecorum genotype (E') that was not used as part of the vaccine formula (MOMP genotypes A, F and G). The predominant MHC class II alleles identified were DAb*19, DAb*21 and DBb*05, with no two koalas identified with the same genetic sequence. Additionally, KoRV-B, which is associated with chlamydial disease outcome, was identified in two (29%) ocular diseased koalas, which still produced vaccine-induced immune responses and clinical ocular improvements post-vaccination. Our findings show promise for the use of a recombinant chlamydial MOMP vaccine for the therapeutic treatment of ocular disease in koalas.


Assuntos
Proteínas da Membrana Bacteriana Externa/imunologia , Vacinas Bacterianas/administração & dosagem , Infecções por Chlamydia/veterinária , Chlamydia/imunologia , Oftalmopatias/prevenção & controle , Phascolarctidae/imunologia , Proteínas Recombinantes/imunologia , Animais , Anticorpos Antibacterianos/sangue , Anticorpos Antibacterianos/imunologia , Vacinas Bacterianas/imunologia , Chlamydia/genética , Infecções por Chlamydia/microbiologia , Infecções por Chlamydia/prevenção & controle , Oftalmopatias/epidemiologia , Oftalmopatias/microbiologia , Feminino , Masculino , Phascolarctidae/microbiologia , Vacinação
17.
BMJ Case Rep ; 12(1)2019 Jan 14.
Artigo em Inglês | MEDLINE | ID: mdl-30642860

RESUMO

Tubercular uveitis is a common manifestation of tuberculosis (TB) in TB-endemic countries. Due to lack of gold standard diagnostic tests for confirming intraocular TB, it is often either underdiagnosed or rarely over diagnosed. We report a case of a 28-year-old woman with diminution of vision in the left eye. She was started on antitubercular treatment (ATT) and steroids but she did not comply with the treatment. She developed progressive painful loss of vision consequently and was treated with vitrectomy and silicone oil tamponade. After a complete course of ATT, she recovered, salvaging of eye and restoration of some vision was possible. Mycobacterium tuberculosis is rarely demonstrated in the ocular fluid samples of the suspected cases of TB due to the paucibacillary nature of the disease. A vitreous sample can be obtained from these patients. Surgical intervention in the form of vitrectomy and silicone oil tamponade can help in avoiding enucleation/evisceration.


Assuntos
Oftalmopatias/microbiologia , Tuberculose Ocular/diagnóstico , Tuberculose Ocular/microbiologia , Uveíte/microbiologia , Baixa Visão/etiologia , Adulto , Antituberculosos/administração & dosagem , Antituberculosos/uso terapêutico , Oftalmopatias/patologia , Feminino , Humanos , Mycobacterium tuberculosis/isolamento & purificação , Cooperação do Paciente , Óleos de Silicone/administração & dosagem , Esteroides/administração & dosagem , Esteroides/uso terapêutico , Resultado do Tratamento , Tuberculose Ocular/tratamento farmacológico , Tuberculose Ocular/patologia , Uveíte/diagnóstico , Uveíte/epidemiologia , Baixa Visão/diagnóstico , Vitrectomia/métodos
18.
Exp Biol Med (Maywood) ; 244(6): 419-429, 2019 04.
Artigo em Inglês | MEDLINE | ID: mdl-30463439

RESUMO

IMPACT STATEMENT: This review describes a growing body of research on relationships between the microbiome and eye disease. Several groups have investigated the microbiota of the ocular surface; dysregulation of this delicate ecosystem has been associated with a variety of pro-inflammatory states. Other research has explored the effects of the gastrointestinal microbiota on ophthalmic diseases. Characterizing the ways these microbiotas influence ophthalmic homeostasis and pathogenesis may lead to research on new techniques for managing ophthalmic disease.


Assuntos
Oftalmopatias/microbiologia , Microbiota , Meio Ambiente , Olho/microbiologia , Olho/patologia , Interações Hospedeiro-Patógeno , Humanos
19.
Indoor Air ; 29(1): 30-42, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-30379348

RESUMO

We studied dampness and mold in China in relation to rhinitis, ocular, throat and dermal symptoms, headache and fatigue. A questionnaire study was performed in six cities including 36 541 randomized parents of young children. Seven self-reported signs of dampness were evaluated. Multilevel logistic regression models were used to calculate odds ratios (ORs). Totally, 3.1% had weekly rhinitis, 2.8% eye, 4.1% throat and 4.8% skin symptoms, 3.0% headache and 13.9% fatigue. Overall, 6.3% of the homes had mold, 11.1% damp stains, 35.3% damp bed clothing, 12.8% water damage, 45.4% window pane condensation, 11.1% mold odor, and 37.5% humid air. All dampness signs were associated with symptoms (ORs from 1.2 to 4.6; P < 0.001), including rhinitis (ORs from 1.4 to 3.2; P < 0.001), and ORs increased by number of dampness signs. The strongest associations were for mold odor (ORs from 2.3 to 4.6) and humid air (ORs from 2.8 to 4.8). Associations were stronger among men and stronger in Beijing as compared to south China. In conclusion, dampness and mold are common in Chinese homes and associated with rhinitis and ocular, throat and dermal symptoms, headache and fatigue. Men can be more sensitive to dampness and health effects of dampness can be stronger in northern China.


Assuntos
Microbiologia do Ar , Poluição do Ar em Ambientes Fechados/efeitos adversos , Fungos , Umidade/efeitos adversos , Adolescente , Adulto , Poluição do Ar em Ambientes Fechados/análise , Criança , China/epidemiologia , Oftalmopatias/epidemiologia , Oftalmopatias/microbiologia , Fadiga/epidemiologia , Fadiga/microbiologia , Feminino , Fungos/isolamento & purificação , Cefaleia/epidemiologia , Cefaleia/microbiologia , Habitação , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Pais , Rinite/epidemiologia , Rinite/microbiologia , Distribuição por Sexo , Dermatopatias/epidemiologia , Dermatopatias/microbiologia , Inquéritos e Questionários , Adulto Jovem
20.
Bioessays ; 40(11): e1800046, 2018 11.
Artigo em Inglês | MEDLINE | ID: mdl-30289987

RESUMO

Until recently, the ocular surface is thought by many to be sterile and devoid of living microbes. It is now becoming clear that this may not be the case. Recent and sophisticated PCR analyses have shown that microbial DNA-based "signatures" are present within various ethnic, geographic, and contact lens wearing communities. Furthermore, using a mouse model of ocular surface disease, we have shown that the microbe, Corynebacterium mastitidis (C. mast), can stably colonize the ocular mucosa and that a causal relationship exists between ocular C. mast colonization and beneficial local immunity. While this constitutes proof-of-concept that a bona fide ocular microbiome that tunes immunity can exist at the ocular surface, there remain numerous unanswered questions to be addressed before microbiome-modulating therapies may be successfully developed. Here, the authors will briefly outline what is currently known about the local ocular microbiome as well as microbiomes associated with other sites, and how those sites may play a role in ocular surface immunity. Understanding how commensal microbes affect the ocular surface immune homeostasis has the potential revolutionize how we think about treating ocular surface disease.


Assuntos
Corynebacterium/crescimento & desenvolvimento , Oftalmopatias/microbiologia , Olho/microbiologia , Microbiota/fisiologia , Simbiose/fisiologia , Animais , Humanos , Doenças Inflamatórias Intestinais/microbiologia , Camundongos
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