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2.
Vet Clin North Am Equine Pract ; 36(2): 303-322, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32654784

RESUMO

Horses perform in a variety of disciplines that are visually demanding, and any disease impacting the eye has the potential to threaten vision and thus the utility of the horse. Advances in equine genetics have enabled the understanding of some inherited ocular disorders and ocular manifestations and are enabling cross-species comparisons. Genetic testing for multiple congenital ocular anomalies, congenital stationary night blindness, equine recurrent uveitis, and squamous cell carcinoma can identify horses with or at risk for disease and thus can assist in clinical management and breeding decisions. This article describes the current knowledge of inherited ocular disorders.


Assuntos
Oftalmopatias/veterinária , Doenças dos Cavalos/genética , Transtornos da Visão/veterinária , Animais , Oftalmopatias/genética , Oftalmopatias/patologia , Testes Genéticos/veterinária , Doenças dos Cavalos/patologia , Cavalos , Transtornos da Visão/genética , Transtornos da Visão/patologia
3.
J Vet Diagn Invest ; 32(3): 382-388, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32207378

RESUMO

Ocular diseases are an important category in equine medicine; however, most articles regarding histologic ocular lesions in horses are exclusive to a specific condition and do not provide a complete review of clinically significant ocular disease frequency in a diagnostic laboratory. We reviewed sections of equine eyes from 140 cases (98 enucleations [biopsies] and 42 autopsies) with clinically relevant ocular alterations at 2 diagnostic centers in the United States. The most common primary conditions were non-traumatic keratitis (36), equine recurrent uveitis (ERU; 31), traumatic injuries (22), ocular and periocular neoplasms (19), and uveitis and/or endophthalmitis resulting from sepsis (18). Congenital anomalies (3) and retinal atrophy and detachment alone (3) were infrequent. Non-traumatic keratitis was frequently accompanied by anterior uveitis (22), corneal rupture (16), pre-iridal fibrovascular membrane formation (13), and secondary mycotic infection (11). ERU was the second and third most prevalent disease in autopsies and enucleations, respectively. This condition was commonly associated with glaucoma (15). Glaucoma (25) and cataract (20) were the most prevalent secondary alterations in the evaluated cases. Keratitis (20) and corneal rupture (16) were among the most prevalent consequences of trauma. Information presented herein may guide clinicians and pathologists, contributing to the early diagnosis of potentially vision-impairing conditions and raising the chances of successful treatment and cure.


Assuntos
Oftalmopatias/veterinária , Doenças dos Cavalos/epidemiologia , Animais , Oftalmopatias/epidemiologia , Oftalmopatias/patologia , Feminino , Doenças dos Cavalos/patologia , Cavalos , Louisiana/epidemiologia , Masculino , Pennsylvania/epidemiologia , Prevalência , Estudos Retrospectivos
4.
Can Vet J ; 61(3): 321-322, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-32165759
5.
J Vet Diagn Invest ; 32(2): 282-286, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31955669

RESUMO

Clostridium perfringens type D epsilon toxin (EXT) causes an important neurologic disorder of sheep, goats and, rarely, cattle. The disease can occur in peracute, acute, subacute, and chronic forms. High circulating levels of ETX produce vasculocentric brain lesions, in which microvascular endothelial injury results in diagnostically useful perivascular and intramural extravasations of plasma protein, especially in sheep, and less frequently in goats. With lower toxin doses, a more protracted clinical course tends to occur, particularly in sheep, leading to focal, bilaterally symmetrical, necrotic foci in certain brain regions. Although these morphologic features usually permit the diagnostic pathologist to make a definitive etiologic diagnosis, there are many aspects of the pathogenesis of these cerebral lesions that are not completely understood. ETX has also been shown to produce microvascular damage in the retina of rats, resulting in severe, diffuse vasogenic edema, similar to that found in brains exposed to this neurotoxin. The pathoclisis and vascular theories offer alternative explanations of the differential susceptibility of different brain regions to the same neurotoxic insult.


Assuntos
Toxinas Bacterianas/toxicidade , Encefalopatias/veterinária , Infecções por Clostridium/veterinária , Clostridium perfringens/fisiologia , Clostridium perfringens/patogenicidade , Oftalmopatias/veterinária , Encefalopatias/diagnóstico , Encefalopatias/microbiologia , Encefalopatias/patologia , Infecções por Clostridium/microbiologia , Infecções por Clostridium/patologia , Oftalmopatias/diagnóstico , Oftalmopatias/microbiologia , Oftalmopatias/patologia , Virulência
6.
J Zoo Wildl Med ; 50(4): 837-844, 2020 Jan 09.
Artigo em Inglês | MEDLINE | ID: mdl-31926513

RESUMO

This study surveyed six North American zoologic institutions to collect retrospective information on the incidence of ocular disease in the giant panda. Reported information included sex and age at presentation, as well as diagnosis, treatment, duration, and clinical outcome for each episode of ocular disease. Among the 42 animals included in the survey, 10 (23.8%) had clinical ocular abnormalities reported. Multiple disease episodes were reported in four animals, with 20 clinical episodes, and one additional animal who presented with corneal scarring from historic keratitis. Age at presentation varied from 0.4 to 26 yr (mean, 11.8 yr; median, 10.4 yr). Corneal abnormalities (including corneal opacity or haze, keratitis, corneal ulcers, and bullous keratopathy) were the most common pathologies reported, followed by conjunctivitis and/or ocular discharge. Additional reported abnormalities included limbal squamous cell carcinoma and lipid degeneration. Six cases resolved without intervention. Treatment protocols included topical and/or systemic medication with or without surgical intervention, which commonly resulted in resolution with or without persistent corneal scar. The prevalence of ocular disease identified in the giant panda in this study is higher than previous publications surveying ocular disease in the family Ursidae, indicating that this is an important source of morbidity in this species.


Assuntos
Animais de Zoológico , Oftalmopatias/veterinária , Ursidae , Animais , Oftalmopatias/epidemiologia , Feminino , Masculino , América do Norte/epidemiologia
7.
J Zoo Wildl Med ; 50(4): 845-852, 2020 Jan 09.
Artigo em Inglês | MEDLINE | ID: mdl-31926514

RESUMO

A complete ophthalmic exam, including intraocular pressure (IOP) measurement, is key to diagnosing ocular diseases such as uveitis and glaucoma in frogs. We performed complete ophthalmic anterior segment examinations and IOP rebound tonometry measurements using two different settings (other "p" and canine "d") for six anuran species. The objectives were to describe common ocular abnormalities found in these species, to compare IOP values between different tonometer settings, and to compare IOPs between species. Examinations revealed abnormalities including cataracts (11/98 total eyes), lenticular sclerosis (10/98) and lipid keratopathy (9/98). IOP was measured with the TonoVet® and the ranges (oculus uterque, OU mm Hg other "p" setting, canine "d" setting) were giant waxy monkey tree frogs (Phyllomedusa bicolor) (3.5-7.6; 6.5-11.7; n = 5), mission golden-eyed tree frogs (Trachycephalus resinifictrix) (7.0-9.7, 13.2-15.7; n = 6), boreal toads (Bufo boreas boreas) (0.8-5.5, 5.7-10.5; n = 13), Mexican giant tree frogs (Pachymedusa dacnicolor) (3.8-5.0, 8.3-11.8; n = 3), Lake Titicaca frogs (Telmatobius culeus) (8.8-10.5, 14.0-17.2; n = 8), and mossy tree frogs (Theloderma corticale) (9.7-11.0, 15.7-17.0; n = 5). The TonoVet canine "d" setting IOP measurements were statistically higher (P = 0.01) than the other "p" setting measurements for all species except the giant waxy monkey tree frogs. IOP was significantly lower for giant waxy monkey tree frog eyes with cataracts (P < 0.05) with the other "p" setting. IOP did not statistically differ in eyes with lenticular sclerosis. IOP can be measured by rebound tonometer in anurans, but more research is needed for species-specific references using consistent settings.


Assuntos
Anuros/fisiologia , Oftalmopatias/veterinária , Pressão Intraocular/fisiologia , Animais , Fenômenos Fisiológicos Oculares
8.
Vet Immunol Immunopathol ; 221: 110012, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31978678

RESUMO

Alterations in serum cytokine levels and profiles have been reported in association with a variety of disease conditions (e.g., allergic, immune-mediated, etc.) in both humans and animals. In comparison to serum cytokine measurements, tear cytokine measurements might be expected to more accurately reflect the inflammatory milieu associated with periocular disease. The purpose of this study was to use a multiplexed assay to compare the cytokine profile of tears in healthy dogs to those with inflammatory skin and periocular disease. We were able to detect IL-2, IL-6, IL-8, and TNF-α in >47 % of tear samples from both healthy canine patients and those with inflammatory dermatologic disease (with or without concurrent periocular involvement). In contrast, IL-7, IL-10 and IFN-γ were rarely detected. Dogs with both dermatologic and periocular disease (but not dermatologic disease alone) had higher levels of IL-8 (P < 0.001, P > 0.05, respectively) relative to healthy dogs. Patients with concurrent dermatologic and periocular disease also demonstrated significantly greater variability in IL-8 concentrations between eyes than did healthy dogs (P < 0.0001). Our findings suggest that tear cytokine analysis may prove to be a useful tool to investigate the role and interactions of the local ocular immune response in patients with inflammatory periocular disease.


Assuntos
Citocinas/imunologia , Doenças do Cão/imunologia , Oftalmopatias/veterinária , Dermatopatias/veterinária , Lágrimas/imunologia , Animais , Cães , Olho/imunologia , Oftalmopatias/imunologia , Feminino , Interleucina-2/imunologia , Interleucina-6/imunologia , Interleucina-8/imunologia , Masculino , Dermatopatias/imunologia , Fatores de Necrose Tumoral/imunologia
9.
Can Vet J ; 61(1): 89-90, 2020 01.
Artigo em Inglês | MEDLINE | ID: mdl-31896836
10.
Parasitol Res ; 119(2): 473-481, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31897790

RESUMO

Equine ocular setariasis arising mainly from ectopic infestation of Setaria digitata is a common vision impairing ophthalmic disease in India, and the identification of this filarial nematode is based solely on morphology. However, morphological characters alone are inadequate to detect and differentiate S. digitata from its congeners. The present communication reports the first phylogenetic characterization of equine S. digitata from India based on sequences derived from the mitochondrial cytochrome c oxidase subunit 1 (COI), the mitochondrial small subunit ribosomal DNA (12S rDNA), and the nuclear internal transcribed spacer 2 (ITS2). Three isolates were characterized for each gene, and respective sequences were submitted to NCBI database (MN078131, MN078132, and MN095798). The sequences were also compared with the other related sequences available from PubMed around the globe, and phylogenetic analysis was carried out in conjunction with nucleotide homologies. There was no intraspecific variation among the Indian isolates. The phylogenetic analysis of S. digitata, inferred from these genes, showed that the isolate sequences obtained from different host species created a separate monophyletic clade within the genus Setaria with minor sequence variations revealing similar molecular characteristics of S. digitata isolates throughout the globe. In addition, the studied Indian isolates were found closer to Sri Lankan isolates. The S. digitata and S. labiatopapillosa appeared as sister species.


Assuntos
Oftalmopatias/veterinária , Filarioidea/isolamento & purificação , Doenças dos Cavalos/parasitologia , Cavalos/parasitologia , Setaria (Nematoide)/isolamento & purificação , Setaríase/parasitologia , Animais , DNA Intergênico/genética , DNA Ribossômico/genética , Complexo IV da Cadeia de Transporte de Elétrons/genética , Oftalmopatias/parasitologia , Filarioidea/genética , Índia , Filogenia , Reação em Cadeia da Polimerase/veterinária , RNA Ribossômico/genética , Análise de Sequência de DNA , Setaria (Nematoide)/genética
11.
N Z Vet J ; 68(2): 126-133, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31608795

RESUMO

Case history: Gradual onset of ocular opacity was observed in three gold-striped geckos (Woodworthia chrysosiretica), and five Pacific geckos (Dactylocnemis pacificus) held in two adjacent terrariums in a zoological institution located in the North Island of New Zealand. Ultraviolet light and heat had been provided for the previous 3-4 years by a fluorescent bulb, but in the last 4 weeks of winter a ceramic heat bulb had been added, situated 10 cm above the upper mesh of the cageClinical findings: All eight geckos presented with mostly bilateral lesions of varying severity confined to the central or upper quadrant of the spectacles. These lesions ranged from variable areas of opacity within the stroma of the spectacle to similarly distributed ulcers of the surface epithelium of both spectacles. The spectacle lesions in the Pacific geckos responded well to treatment with topical combined antimicrobial therapy, within 18-29 days. The gold-striped geckos suffered complications including dysecdysis, severe spectacle ulceration and perforation, mycotic spectaculitis, and widespread mycotic dermatitis resulting in death or leading to euthanasia.Pathological findings: In the three gold-striped geckos, there were extensive areas of deep ulceration and replacement of the spectacle with a thick serocellular crust containing large numbers of fungal elements. The affected areas of the stroma were expanded by large deposits of proteinaceous and mucinous material, pyknotic cellular debris and moderate numbers of heterophils and macrophages as well as infiltrating fungal hyphae.Diagnosis: Mycotic spectaculitis with ulceration and perforation, and disseminated mycotic dermatitis likely secondary to thermal burns.Clinical relevance: This is the first report of thermal burns of the spectacle in any reptile. There was species variation in the burn severity with gold-striped geckos showing more severe lesions, possibly due to a mix of behavioural and anatomical factors. The thermal burns to the spectacles in three cases were complicated by delayed healing, perforation, dysecdysis and severe mycotic infection.


Assuntos
Queimaduras/veterinária , Oftalmopatias/veterinária , Calefação/instrumentação , Abrigo para Animais , Lagartos , Animais , Animais de Zoológico , Anti-Infecciosos/administração & dosagem , Anti-Infecciosos/uso terapêutico , Anti-Inflamatórios não Esteroides/uso terapêutico , Bacitracina/administração & dosagem , Bacitracina/uso terapêutico , Queimaduras/etiologia , Combinação de Medicamentos , Oftalmopatias/etiologia , Oftalmopatias/patologia , Meloxicam/uso terapêutico , Neomicina/administração & dosagem , Neomicina/uso terapêutico , Polimixina B/administração & dosagem , Polimixina B/uso terapêutico , Raios Ultravioleta
12.
J Aquat Anim Health ; 31(4): 354-363, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31765509

RESUMO

The order Saprolegniales (Class Oomycota) is a group of fungus-like eukaryotic microorganisms that have been associated with infections in fish and fish eggs. Infections with microorganisms from this order are clearly evident because they have a cotton wool-like appearance. The aim of this study was to characterize and identify an oomycete that was isolated from the eye of an Orange Blotched Peacock Cichlid Aulonacara sp. A sample of cotton wool-like mycelia was isolated and single-spore isolations were conducted. Molecular characterization and phylogenetic analysis of the ITS1-5.8-ITS2 rDNA region for all isolates were used for species identification. Following molecular identification, one isolate was used to culture and characterize the reproductive structures. Physiological characterization entailed incubating the isolate on potato dextrose agar (PDA) at five different temperatures, ranging from 5°C to 25°C, to monitor growth rates. A multiple sequence alignment showed 100% similarity between all of the single-spore isolates and alignment with other Achlya bisexualis strains. Long, coarse hyphae with zoosporangia and gemmae typical of the order Saprolegniales were observed with an optimal growth rate at 25°C. The oomycete that was isolated from an Orange Blotched Peacock Cichlid was identified as A. bisexualis, the first record of this species in South Africa.


Assuntos
Ciclídeos , Oftalmopatias/veterinária , Doenças dos Peixes/microbiologia , Infecções/veterinária , Saprolegnia/fisiologia , Animais , Oftalmopatias/microbiologia , Infecções/microbiologia , Saprolegnia/classificação , África do Sul
13.
Parasitol Res ; 118(12): 3549-3553, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31722066

RESUMO

Thelazia callipaeda, originally known as an "Oriental eyeworm," is a small nematode parasitizing the conjunctival sacs of domestic and wild animals and humans. Previous studies conducted in Serbia have reported the eyeworm infections in dogs, cats, and foxes, as well as in a human patient. As the data regarding thelaziosis from wildlife is still scarce, the aim of this study was to investigate the presence of T. callipaeda in gray wolf (Canis lupus) from Serbia. All collected nematodes were morphologically identified as T. callipaeda males (n = 64) or females (n = 225). Molecular characterization, conducted by PCR amplification followed by sequence analysis of partial cytochrome c oxidase subunit 1 gene (cox1), revealed only haplotype 1 of T. callipaeda. The overall prevalence of thelaziosis was 38.1% (8/21). In all positive animals, both eyes were affected, with a total parasitic load ranging from four to 132 worms per animal. Our results indicate the important epidemiological role of wolves as wildlife reservoirs of T. callipaeda, expanding geographic range of infection, as well as intra- and interspecies contact rates, although the role of other wild carnivore species (i.e., foxes and jackals) should be investigated in future studies.


Assuntos
Oftalmopatias/veterinária , Infecções por Spirurida/veterinária , Thelazioidea/isolamento & purificação , Lobos/parasitologia , Animais , Animais Selvagens/parasitologia , Gatos , Cães , Olho/parasitologia , Oftalmopatias/parasitologia , Feminino , Raposas/parasitologia , Masculino , Prevalência , Sérvia , Infecções por Spirurida/parasitologia , Thelazioidea/classificação , Thelazioidea/genética
14.
Top Companion Anim Med ; 36: 4-8, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31472726

RESUMO

This report describes a 10-month-old dog with a sudden loss of vision and severe dyspnoea. The ocular examination revealed bilateral panuveitis, lens subluxation, secondary glaucoma, and retinal detachment. In addition, the ocular ultrasound showed in the vitreous body of the right eye, a small doubled-lined foreign body compatible with an intraocular parasite. Radiographs of the thorax revealed an increased opacity with mixed lung pattern (alveolar and bronchial) and thoracic ultrasonography showed several subpleural nodules. The presence of Angiostrongylus vasorum first stage larvae was confirmed with 324 larvae per gram of feces and an antigen test for the parasite (AngioDetect, IDEXX) also yielded a positive result. The severe and irreversible ocular lesions described in this case enhanced the complexity of the clinical picture of canine angiostrongylosis. Infection with the parasite should be included in the list of differential diagnoses for ocular uveitis to avoid potentially serious complications related to a missed or delayed diagnosis.


Assuntos
Angiostrongylus/isolamento & purificação , Doenças do Cão/parasitologia , Oftalmopatias/veterinária , Infecções por Strongylida/veterinária , Animais , Doenças do Cão/diagnóstico , Doenças do Cão/tratamento farmacológico , Cães , Oftalmopatias/diagnóstico , Oftalmopatias/tratamento farmacológico , Oftalmopatias/parasitologia , Fezes/parasitologia , Feminino , Glaucoma/complicações , Itália , Subluxação do Cristalino/parasitologia , Subluxação do Cristalino/veterinária , Pneumopatias Parasitárias/diagnóstico por imagem , Pneumopatias Parasitárias/veterinária , Pan-Uveíte/parasitologia , Pan-Uveíte/veterinária , Descolamento Retiniano/parasitologia , Descolamento Retiniano/veterinária , Infecções por Strongylida/diagnóstico , Infecções por Strongylida/tratamento farmacológico
16.
Can Vet J ; 60(7): 744-748, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31281192

RESUMO

The standard placement of a subpalpebral lavage system may not be feasible in some horses with eyelid disease. We describe placement of a commercially available, indwelling nasolacrimal lavage system that circumvents eyelid perforation. This novel approach provided for effective delivery of drugs to 1 horse with periocular and corneal disease.


Assuntos
Doenças da Córnea/veterinária , Oftalmopatias/veterinária , Doenças Palpebrais/veterinária , Doenças dos Cavalos , Animais , Cavalos , Irrigação Terapêutica/veterinária
17.
Parasitol Res ; 118(9): 2531-2541, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31286263

RESUMO

Visual performance and environmental conditions can influence both behavioral patterns and predator-prey interactions of fish. Eye parasites can impair their host's sensory performance with important consequences for the detection of prey, predators, and conspecifics. We used European perch (Perca fluviatilis) experimentally infected with the eye fluke Tylodelphys clavata and evaluated their feeding behavior and competitive ability under competition with non-infected conspecifics, in groups of four individuals, for two different prey species (Asellus aquaticus and Daphnia magna). To test whether the effect of T. clavata infection differs at different light conditions, we performed the experiments at two light intensities (600 and 6 lx). Foraging efficiency of perch was significantly affected by infection but not by light intensity. The distance at which infected fish attacked both prey species was significantly shorter in comparison to non-infected conspecifics. Additionally, infected fish more often unsuccessfully attacked A. aquaticus. Although the outcome of competition depended on prey species, there was a general tendency that non-infected fish consumed more of the available prey under both light intensities. Even though individual prey preferences for either A. aquaticus or D. magna were observed, we could not detect that infected fish change their prey preference to compensate for a reduced competitive foraging ability. As infection of T. clavata impairs foraging efficiency and competitive ability, infected fish would need to spend more time foraging to attain similar food intake as non-infected conspecifics; this presumably increases predation risk and potentially enhances transmission success to the final host.


Assuntos
Comportamento Alimentar/fisiologia , Percas/parasitologia , Comportamento Predatório/fisiologia , Trematódeos/patogenicidade , Visão Ocular/fisiologia , Animais , Oftalmopatias/parasitologia , Oftalmopatias/veterinária , Interações Hospedeiro-Parasita/fisiologia
18.
J Helminthol ; 94: e56, 2019 Jun 28.
Artigo em Inglês | MEDLINE | ID: mdl-31248467

RESUMO

The causes of the beaching and death of sea turtles have not been fully clarified and continue to be studied. Mild, moderate and severe lesions caused by spirorchiidiosis have been seen for decades in different organs and were recently defined as the cause of death of a loggerhead turtle. In the present study, eyes and optic nerves were analysed in green sea turtles with spirorchiidiosis and no other debilitating factors. Injuries to the optic nerve and choroid layer were described in 235 animals (90%) infected with spirorchiids. Turtles with ocular spirorchiidiosis are approximately three times more likely to be cachectic than turtles with spirorchiidiosis without ocular involvement.


Assuntos
Oftalmopatias/veterinária , Olho/parasitologia , Infecções por Trematódeos/veterinária , Tartarugas/parasitologia , Animais , Brasil , Oftalmopatias/parasitologia , Feminino , Nervo Óptico/parasitologia , Nervo Óptico/patologia , Trematódeos/patogenicidade
19.
J Helminthol ; 94: e57, 2019 Jun 28.
Artigo em Inglês | MEDLINE | ID: mdl-31250780

RESUMO

Eye flukes are common infections of freshwater fish and their occurrence as metacercarial stages may occur non-randomly resulting in an asymmetrical distribution within the host eyes. However, from previous studies the presentation of bias by these trematodes lacks consistency suggesting that congenital asymmetrical effects are unlikely to be the cause and exogenous factors, such as environmental stress, may be more influential. The present study, undertaken over a 4-year period, investigates the impact of an extreme heatwave and drought on the annual bilateral asymmetry and occurrence of two eye fluke species (Diplostomum sp. in the lens and Tylodelphys sp. in the vitreous humour) from perch (Perca fluviatilis) and roach (Rutilus rutilus). The onset of the extreme climatic event resulted in a significant negative effect on the occurrence of the eye flukes. Bilateral asymmetry, which was present within both trematode species and hosts, appeared to be highly variable between eye fluke and fish species and also year of study. However, during the pre-drought period both host species demonstrated significant asymmetry for Tylodelphys sp. but not for Diplostomum sp. while during the drought this bias was reversed. The potential role of fluctuating asymmetry of fish hosts in structuring the bilateral asymmetry of eye flukes is discussed.


Assuntos
Clima , Oftalmopatias/veterinária , Doenças dos Peixes/parasitologia , Percas/parasitologia , Trematódeos/fisiologia , Animais , Secas , Inglaterra , Olho/parasitologia , Oftalmopatias/parasitologia , Temperatura Alta , Lagos/parasitologia
20.
Vet Pathol ; 56(5): 749-760, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31132943

RESUMO

This study describes clinical and histopathological features, treatment, and outcome of cats diagnosed with ocular mycobacteriosis. Cases diagnosed from 2012 to 2017 were reviewed for (a) histopathological evidence of ocular (pyo)granulomatous inflammation containing acid-fast bacilli with mycobacterial morphology, (b) positive mycobacterial culture and/or mycobacterial DNA identified by polymerase chain reaction of ocular tissue, or (c) presumed mycobacteriosis based on ophthalmic examination and positive interferon-gamma release assay. Twenty-five cats (31 eyes) were included; 14 cats (17/31 eyes, 55%) were blind at presentation (unilateral: n = 12 cats; bilateral: n = 2 cats); one unilaterally affected cat later became bilaterally blind. Another 5 cats (7/31 eyes, 23%) became blind after initially being bilaterally visual (unilateral: n = 3 cats; bilateral: n = 2 cats). The commonest ocular finding was uveitis (87%). The main histopathological features were granulomatous to pyogranulomatous chorioretinitis with retinal detachment, anterior uveitis, optic neuritis, episcleritis, scleritis, and/or retrobulbar cellulitis. Nineteen cats (76%) had systemic signs, with disseminated disease being diagnosed in 9, defined by interstitial pulmonary disease, generalized lymphadenopathy, and/or nonocular infection. Nine cats were diagnosed with Mycobacterium bovis, 2 with Mycobacterium microti, 1 with Mycobacterium tuberculosis complex, and 1 with Mycobacterium avium-intracellulare complex. The infecting species was unknown in the remaining cats. Combined surgery (enucleation: n = 5 cats; biopsy: n = 3 cats) and systemic treatment with 2 or 3 appropriate antibiotics for 2 to 7 months resulted in remission in 8 of the 10 cats treated; however, the cat treated with dual therapy relapsed after 8 months. A total of 16 cats (64%) were euthanized; 2 were lost to follow-up.


Assuntos
Doenças do Gato/microbiologia , Oftalmopatias/veterinária , Infecções por Mycobacterium/veterinária , Mycobacterium/isolamento & purificação , Animais , Antibacterianos/uso terapêutico , Doenças do Gato/patologia , Doenças do Gato/terapia , Gatos , Oftalmopatias/microbiologia , Mycobacterium/classificação , Infecções por Mycobacterium/microbiologia , Infecções por Mycobacterium/terapia , Estudos Retrospectivos , Resultado do Tratamento
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