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1.
Clin Nutr ESPEN ; 53: 196-205, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36657914

RESUMO

BACKGROUND & AIMS: We aimed to estimate the prevalence of the inadequate intake and status of magnesium, zinc, and vitamins A, C, E, and D and identify factors associated with micronutrient deficiency in serum/plasma among residents of São Paulo, Brazil. METHODS: Data from 824 individuals aged ≥14 years were obtained from the 2015 ISA-Nutrition, a population-based, cross-sectional survey. Dietary and supplement intakes were assessed using two 24-h dietary recalls, and the micronutrient inadequacies were estimated using the National Cancer Institute method. Micronutrient status was measured in serum or plasma, and deficiency was established according to the lower limit of the reference values. Receiver operating characteristic curve analysis was used to identify the effect of intake on the micronutrient status in serum/plasma. Logistic regression analysis was applied to assess the association between micronutrient status and individual characteristics. RESULTS: More than 80% of the population had an inadequate dietary intake of magnesium, vitamin E, and vitamin D. Males had a high prevalence of inadequate dietary intake of vitamin A and zinc. A high-to-moderate prevalence of inadequate vitamin C intake was observed. Vitamin D was the only nutrient with a deficient status comparable to its dietary inadequacy. The other nutrients demonstrated a lower deficiency prevalence compared to dietary inadequacy, and vitamin A demonstrated the lowest prevalence of deficiency in plasma. Generally, dietary intake showed a non-notable association with micronutrient deficiency in serum/plasma. Individuals with fasting glucose concentrations ≥100 mg/dL and those using diuretic drugs had a higher risk of serum magnesium deficiency. Those using lipid-lowering drugs and those with high plasma adiponectin concentrations had a higher risk of serum zinc deficiency. Individuals who smoked and those with hypertension showed a higher risk of plasma vitamin C deficiency. Individuals with average leptin concentrations had a higher risk of plasma vitamin E deficiency. Finally, those with sufficient leisure-time physical activity had a lower risk of serum vitamin D deficiency. CONCLUSIONS: Residents of the urban areas of São Paulo demonstrated substantially inadequate intakes of most of the assessed micronutrients; however, micronutrient deficiency in serum/plasma was not associated with dietary inadequacy, and it usually demonstrated a lower prevalence than dietary indicators. Thus, using micronutrient intake to determine the serum/plasma profile should be done with caution. The status of the micronutrients varied according to individual characteristics, indicating the interplay of complex mechanisms underlying micronutrient balance.


Assuntos
Desnutrição , Micronutrientes , Oligoelementos , Vitaminas , Humanos , Masculino , Brasil/epidemiologia , Estudos Transversais , Magnésio , Micronutrientes/deficiência , Oligoelementos/deficiência , Vitamina A , Vitamina D , Vitamina K , Zinco , Desnutrição/epidemiologia , Dieta
2.
Molecules ; 28(2)2023 Jan 04.
Artigo em Inglês | MEDLINE | ID: mdl-36677560

RESUMO

The present study investigated the isotopic and elemental profile (by IRMS and ICP-MS) of edible egg parts (29 egg whites and 29 yolks) mainly collected from Romania. In order to differentiate the egg white and yolk coming from different hen rearing systems (backyard and barn), Partial Least Square-Discriminant Analysis (PLS-DA) models were developed. The models' accuracies for the discrimination according to the hen growing system were 96% for egg white and 100% for egg yolk samples, respectively. Elements that proved to have the highest discrimination power for both egg white and yolk were the following: δ13C, Li, B, Mg, K, Ca, Mn, Fe, Co, Zn, Rb, Sr, Mo, Ba, La, Ce, and Pb. Nevertheless, the important compositional differentiation, in terms of essential mineral content, between the edible egg parts (egg white and egg yolk) were also pointed out. The estimated daily intake (EDI), the target hazard quotient (THQ) for Cr, Mn, Fe, Co, Ni, Cu, Zn, Se, Cd, Pb, and As, as well as the hazard index (HI) were used to assess non-carcinogenic human health risks from egg consumption. The obtained results showed no noticeable health risks related to egg consumption for humans from the point of view of the potentially toxic metals.


Assuntos
Metais Pesados , Oligoelementos , Feminino , Animais , Humanos , Galinhas , Chumbo/análise , Análise Espectral , Medição de Risco , Minerais/análise , Metais Pesados/análise , Monitoramento Ambiental , Oligoelementos/análise
3.
Ecotoxicol Environ Saf ; 250: 114467, 2023 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-36587414

RESUMO

Rapid economic development and industrialization may include environmentally harmful human activities that cause heavy-metal accumulation in soils, ultimately threatening the quality of the soil environment and human health. Therefore, accurate identification of pollution sources is an important weapon in efforts to control and prevent pollution. The self-organizing map (SOM) method is widely used in pollution source identification because of its capacity for visualization of high-dimensional data. The SOM ignores the graph structure relationship among chemical elements in soils; the SOM analysis of pollution sources has high uncertainty. Here, we propose a new analysis method, i.e., the graph convolutional self-organizing map (GCSOM), which uses a graph convolutional network (GCN) to extract the graph structure relationship among the chemical elements in soils, then performs data visualization using an SOM. We compared the performances of GCSOM and SOM, then assessed the pollution source characteristics of trace metal(loid)s (TMs, mostly heavy metals) in Jiangmen City using the GCSOM. Our experimental results showed that the GCSOM is superior to the SOM for identification of TM sources, while the TMs in the soil of Jiangmen originate from three main sources: agricultural activities (mainly in Taishan City, Jiangmen), traffic emissions (mainly in Xinhui and Pengjiang Districts), and industrial activities (mainly in Xinhui District). The risk assessment indicated that the risk of all TMs was within threshold.


Assuntos
Metais Pesados , Poluentes do Solo , Oligoelementos , Humanos , Solo/química , Monitoramento Ambiental/métodos , Poluentes do Solo/análise , China , Metais Pesados/análise , Oligoelementos/análise , Medição de Risco , Aprendizado de Máquina
4.
Int J Mol Sci ; 24(2)2023 Jan 09.
Artigo em Inglês | MEDLINE | ID: mdl-36674772

RESUMO

Biometals are all metal ions that are essential for all living organisms. About 40% of all enzymes with known structures require biometals to function correctly. The main target of damage by biometals is the central nervous system (CNS). Biometal dysregulation (metal deficiency or overload) is related to pathological processes. Chronic occupational and environmental exposure to biometals, including iron and copper, is related to an increased risk of developing Parkinson's disease (PD). Indeed, biometals have been shown to induce a dopaminergic neuronal loss in the substantia nigra. Although the etiology of PD is still unknown, oxidative stress dysregulation, mitochondrial dysfunction, and inhibition of both the ubiquitin-proteasome system (UPS) and autophagy are related to dopaminergic neuronal death. Herein, we addressed the involvement of redox-active biometals, iron, and copper, as oxidative stress and neuronal death inducers, as well as the current metal chelation-based therapy in PD.


Assuntos
Doença de Parkinson , Oligoelementos , Humanos , Doença de Parkinson/patologia , Cobre , Metais , Ferro , Estresse Oxidativo , Oxirredução , Neurônios Dopaminérgicos/patologia , Quelantes/farmacologia , Quelantes/uso terapêutico
5.
Nutrients ; 15(1)2023 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-36615875

RESUMO

Longevity, as a complex life-history trait, shares an ontogenetic relationship with other quantitative traits, such as epigenetic and environmental factors. Therefore, it is important to identify environmental factors that may modify the epigenome to establish healthy aging. This study explored the association between tap drinking water and longevity in Cilento, Italy, to understand whether trace elements in local drinking water may have an influence on old, nonagenarian, and centenarian people and promote their health and longevity. Data on population and water sources were collected through the National Demographic Statistics, the Cilento Municipal Archives, and the Cilento Integrated Water Service. Ordinary least squares (OLS) regression and a geographically weight regression (GWR) model were used to study the spatial relationship between the explanatory and outcome variables of longevity. The results of the study showed that the prevalence of longevity is concentrated in the central, northern and southeastern areas of the territory and that some trace elements present in tap water may contribute to local longevity in Cilento. Specifically, all Cilento municipalities had alkaline tap water, and the municipalities with the highest longevity concentrations had higher alkalinity levels than the other municipalities, soft to medium-hard water hardness, an amount of total dissolved solids equivalent to the level of excellent water, lower amounts of sodium, adequate iron concentration, and adequate dietary intake of manganese per day.


Assuntos
Água Potável , Oligoelementos , Idoso de 80 Anos ou mais , Humanos , Longevidade , Água Potável/análise , Oligoelementos/análise , Nonagenários , Centenários , Itália/epidemiologia
6.
Food Res Int ; 163: 112165, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36596113

RESUMO

The ionic elements in wine and in vineyards are gaining attention due to characterization of the wine traits, wine origin tracing, and vine nutrient judging. In this experiment, 19 elements were detected by inductively coupled plasma mass spectrometry (ICP-MS) in 69 wine samples from 4 regions, 3 vintages, and 3 grape maturity levels. Furthermore, the elements related to vine development, such as N, P, K, Ca, Mg, Cu, Fe, Zn and Cu in the vineyard soil and petioles were determined. Two orthogonal partial least squares discriminant analysis (O2PLS-DA) showed that K, Mn, Co, Sr, B, Si, Pb, Ni, Cu, and Zn were important elements in distinguishing the regions. High-temperature vintages can bring wines with high levels of Sr in wine. Na, Ca, K, Mg, Rb, Al, Rb, Pb and Fe can be used as signature elements to distinguish wines made from 2 grape maturities. And Cu, Zn, and Mn were the key elements used to differentiate the petioles in the 4 regions. Partial square regression (PLSR) analysis showed that soil pH was positively correlated with Al, B, Ba, K, Pb, Mn, Sr and Rb in wine, and K in wine was significantly positively correlated with element K in the soil. In conclusion, the elemental contents in wine are shaped by the combination of origin, vintage and grape maturity, while some key elements can be used as indicators of origin traceability.


Assuntos
Oligoelementos , Vitis , Oligoelementos/análise , Vitis/química , Espectrometria de Massas , Chumbo/análise , Solo
7.
BMC Cancer ; 23(1): 14, 2023 Jan 05.
Artigo em Inglês | MEDLINE | ID: mdl-36604732

RESUMO

PURPOSE: No data on predicting the survival of AML patients based on the level of trace elements in the serum have been presented to date. The aims of this prospective cohort study were as follows: (i) to evaluate the serum Cu and Zn levels in people from Northeast China, (ii) to assess the association between the serum Cu level (SCL) and Cu to Zn ratio (SCZR) and clinical and nutrition data, and (iii) to investigate the predictive values of the SCL and SCZR in newly diagnosed de novo AML patients. METHODS: A total of 105 newly diagnosed AML patients and 82 healthy controls were recruited. The serum Cu and Zn levels were determined by inductively coupled plasma spectrometry. The associations of SCL and SCZR with the survival of these AML patients were assessed by Cox proportional hazards models. RESULTS: Both SCL and SCZR were positively related to the blast percentage of bone marrow and C-reactive protein, negatively related to albumin level and CEBPA double mutation and were significantly associated with worse overall survival and disease-free survival. Meanwhile, patients with higher SCL had worse CTCAE levels, and patients with higher SCZR showed less complete remission during the first course of induction chemotherapy. Moreover, higher SCZR was positively associated with ELN risk stratification, and was negatively associated with haemoglobin level and prognostic nutritional index (PNI). CONCLUSION: The SCL and SCZR are associated with long-term survival in patients with newly diagnosed AML undergoing intensive induction and may serve as important predictive biomarkers.


Assuntos
Leucemia Mieloide Aguda , Oligoelementos , Humanos , Cobre , Zinco , Estudos Prospectivos , Leucemia Mieloide Aguda/genética
8.
Nutrients ; 15(2)2023 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-36678211

RESUMO

COVID-19 infection can spread in the host body without any adequate immune response. Zinc is an essential trace element with strong immunoregulatory and antiviral properties and its deficiency might lead to inflammation and oxidative stress. The aim of the current study was to determine the association of serum zinc and inflammatory markers with the severity of COVID-19 infection. This was a prospective observational study in which 123 COVID-19-positive adult patients and 48 controls were recruited. The initial comparative analysis was conducted between COVID-19 patients and controls. COVID-19-positive patients were further divided into three different groups (mild, moderate, and severe) based on the severity of COVID-19 infection. COVID-19 patients showed significantly lower serum zinc levels (8.8 ± 2.3 µmol/L) compared to healthy controls (11.9 ± 1.8 µmol/L). There was a negative correlation between serum zinc levels and the severity of COVID-19 infection (r = -0.584, p < 0.0001) and this effect was independent of age (r = -0.361, p < 0.0001). Furthermore, inflammatory markers showed a positive correlation with the severity of COVID-19 infection and a negative correlation with the levels of serum zinc. The study demonstrated an association between COVID-19 infection with low serum zinc levels and elevated inflammatory markers. Further studies to assess the significance of this observation are needed, which may justify zinc supplementation to mitigate the severity of COVID-19 infection.


Assuntos
COVID-19 , Oligoelementos , Humanos , Adulto , SARS-CoV-2 , Inflamação , Zinco
9.
Nutrients ; 15(2)2023 Jan 12.
Artigo em Inglês | MEDLINE | ID: mdl-36678252

RESUMO

Ultra-processed food (UPF) consumption impacts nutrient intake and plays an important role in non-communicable diseases (NCD), even among schoolchildren. This cross-sectional study aimed to characterize the food consumption of this population and its relationship with laboratory and anthropometric aspects. A sample of 190 subjects aged 5 to 19 y was randomly selected for dietary, laboratory, and anthropometric assessment. Statistical inference was calculated using Spearman's correlation. Excess weight was observed in 34%, a high Waist-to-Height Ratio in 9%, and hypertriglyceridemia in 17% of the subjects, higher among those from urban schools (45%, p = 0.011; 15%, p = 0.015; 24%, p = 0.026, respectively). UPF consumption represented 21% of caloric intake and showed a positive correlation with trans fatty acids (r = 0.70) and sugar (r = 0.59) intake. Unprocessed food consumption showed a weak, but significant, correlation with Body Mass Index (r = 0.22) and Waist Circumference (r = 0.23), while processed meat showed a negative correlation with serum ferritin (r = -0.16) and vitamins D (r = -0.20) and B12 (r = -0.15). These findings highlight the need for public policies to promote Food and Nutritional Security for schoolchildren to prevent NCD and nutritional deficiencies.


Assuntos
Doenças não Transmissíveis , Oligoelementos , Ácidos Graxos trans , Humanos , Criança , Brasil/epidemiologia , Ácidos Graxos trans/efeitos adversos , Micronutrientes , Estudos Transversais , Doenças não Transmissíveis/epidemiologia , Fast Foods/efeitos adversos , Ingestão de Energia , Dieta , Açúcares , Manipulação de Alimentos
10.
Mar Environ Res ; 184: 105872, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36621131

RESUMO

This study recompiled a national dataset to characterize the pollution level and health risk of cadmium (Cd), copper (Cu), lead (Pb) and zinc (Zn) in oysters along the coastal areas of China. Results showed that the median concentrations of Cd, Cu, Pb and Zn in nationwide oysters were 5.5, 335, 1.3 and 1280 mg/kg dry weight, respectively. Generally, oysters from the north coasts presented lower metal pollution and higher quality than those from the south. The regional characteristics of trace metals in oysters might be contributed by the interspecific differences. Nationally, the noncarcinogenic risk posed by these four metals in oysters was relatively low, with the risk only occurring in a few hotspots such as the Pearl River Estuary and the Jiulong River Estuary. However, more attention should be paid to the carcinogenic risk of Cd, and priority should be given to formulating control measures to mitigate Cd pollution.


Assuntos
Metais Pesados , Ostreidae , Oligoelementos , Poluentes Químicos da Água , Humanos , Animais , Metais Pesados/análise , Cádmio , Bioacumulação , Chumbo , Poluentes Químicos da Água/análise , China , Monitoramento Ambiental/métodos
11.
Artigo em Inglês | MEDLINE | ID: mdl-36673943

RESUMO

There is growing concern regarding the effects of toxic element exposure on the development of children. However, little is known about the level of toxic elements exposure in Japanese children. The purpose of this study was to assess the concentrations of multiple elements (aluminum, cadmium, lead, calcium, copper, iron, magnesium, sodium, zinc) in the hair of 118 Japanese young children and to explore the factors associated with their element levels. The element concentration was analyzed by ICP-MS, and children's food and water intake were assessed by the questionnaire. Results showed that there were no large differences between the level of elements in the hair of Japanese children and those of children in other developed countries. Girls had significantly higher levels of aluminum, copper, and iron (p = 0.000, 0.014, and 0.013, respectively), and boys had a higher level of sodium (p = 0.006). The levels of calcium, iron, magnesium, and sodium in nursery school children were significantly higher than those in kindergarten children (p = 0.024, 0.001, 0.046, and 0.029, respectively). Multiple regression analyses with controlling the confounding variables showed significant negative associations of frequency of yogurt intake with aluminum and lead levels (p = 0.015 and 0.037, respectively). When the children were divided into three groups based on the frequency of yoghurt consumption, viz. L (≤once a week), M (2 or 3 times a week), and H (≥4 to 6 times a week) group, the mean aluminum concentration (µg/g) in the L, M, and H groups was 11.06, 10.13, and 6.85, while the mean lead concentration (µg/g) was 1.76, 1.70, and 0.87, respectively. Our results suggested the validity of hair element concentrations as an exposure measure of essential elements and frequent yogurt intake as a viable measure for protecting children from toxic elements. However, these findings will need to be confirmed in more detailed studies with larger sample sizes in the future.


Assuntos
Oligoelementos , Masculino , Feminino , Humanos , Criança , Pré-Escolar , Oligoelementos/análise , Cobre , Chumbo/análise , Magnésio/análise , Alumínio , Cálcio , Ferro , Cabelo/química , Sódio
12.
Artigo em Inglês | MEDLINE | ID: mdl-36674355

RESUMO

A comprehensive, large-scale coastal investigation of antibiotics in seawater from Bohai Bay is lacking. Therefore, in this study, we investigated the occurrence and ecological risks of 45 antibiotics belonging to 5 classes in seawater from Bohai Bay, as well as their inter-relation with trace elements and other contaminants. The results show that tetracyclines (TCs) were detected in the highest concentration among the five classes (in the range of 0.6-2.0 µg/L). The total concentrations of the five classes of antibiotics were detected in the following order: tetracyclines (TCs) > quinolones (QAs) > sulfonamides (SAs) > macrolides (MAs) > lactams (LAs). Higher antibiotic concentrations were detected at the sampling sites closest to the coast or the shipping port. Among seven trace elements, four were quantitatively detected, with Zn representing the highest concentration. Antibiotic residuals were found to be positively correlated with total organic carbon (TOC), conductivity (Ec) and suspended solids (SS); pH and NH4+-N usually showed a negative correlation with antibiotics; TN and TP also exhibited relationships with antibiotics. The risk quotient (RQ) was calculated for different antibiotics at different sites. It was found that antibiotics pose higher risks to algae than to invertebrates or fish; sulfamethoxazole, enrofloxacin and ofloxacin were all found to pose high risk to algae at some of the sampling sites. Structural equation model (SEM) results show that trace elements, antibiotic levels and EC50 are the main factors affecting the ecological risks of antibiotics.


Assuntos
Oligoelementos , Poluentes Químicos da Água , Animais , Antibacterianos/análise , Baías , Água do Mar/química , Tetraciclinas , China , Monitoramento Ambiental , Poluentes Químicos da Água/análise , Medição de Risco
13.
Environ Monit Assess ; 195(2): 314, 2023 Jan 20.
Artigo em Inglês | MEDLINE | ID: mdl-36662368

RESUMO

Stratified water collection plays a crucial role in water quality monitoring, as most water bodies are not perfectly mixed systems. In order to precisely collect stratified waters, we developed an inexpensive, simple, and high-resolution sampler to simultaneously collect and measure physical and chemical parameters along vertical water profiles. The water sampler predominantly consists of two parts: (1) an apparatus for measuring sampling depth below the water and (2) water sampling units secured below the water. Proof of concept water sampling was performed in Caohai wetland (Southwest China) at 40 cm intervals, as sampling depth and interval are adjustable. Stratified waters in four sampling sites were characterized by markedly different levels of major and trace elements as well as physicochemical parameters. Results indicate this simple multilevel sampler to be a cheap, precise, and portable option for simultaneously collecting water samples at different depths in a wide array of water body types.


Assuntos
Oligoelementos , Poluentes Químicos da Água , Poluentes Químicos da Água/análise , Monitoramento Ambiental/métodos , Qualidade da Água , China
14.
Talanta ; 255: 124248, 2023 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-36608423

RESUMO

In this study, a laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) method for in-situ determination of yttrium and trace elements in yttrium-doped barium fluoride (BaF2: Y) crystals was proposed. A facile, micro-damage procedure for quantifying the segregation coefficient of doping elements was investigated, and it was found that the actual yttrium doping concentration increases from the seed end to the tail end in BaF2: Y crystals. In micro-area analysis, this method has higher mass sensitivity which was applied to quantify the impurity content and distribution during the growth of BaF2: Y crystals. Regression coefficient of calibration curve for each element ranged from 0.9918 to 0.9995. Detection limits (DLs) were 0.05, 0.03, 0.01 and 0.01 µg g-1 for Mg, Zn, Sr and Pb, respectively. The accuracy of the proposed method was verified by inductively coupled plasma mass spectrometry/atomic emission spectroscopy (ICP-MS/AES) with wet-chemical pretreatment. The objective of the presented work was to provide a less damaging and more novelty approach for crystal sample analysis.


Assuntos
Terapia a Laser , Oligoelementos , Oligoelementos/análise , Ítrio , Análise Espectral , Espectrometria de Massas/métodos
15.
Environ Res ; 219: 115027, 2023 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-36502912

RESUMO

Identifying the contamination characteristics of trace metals in river and targeting their corresponding potential contamination sources and source-specific ecological risk are of very importance for putting forward effective river environment protection strategies. Here, a detailed investigation was conducted to recognize the contamination and ecological risk characteristics of trace metals in Le'an River. To attain this objective, a PMF-SSD model (Positive Matrix Factorization-Species Sensitivity Distribution) was proposed to evaluate the ecological risk of trace metals in Le'an River. The positive matrix factorization (PMF) was employed to identify the potential source of trace metals in surface water and their corresponding contributions. The ecological risks of the sources were quantitatively calculated by PMF-SSD. In addition, the spatial dissimilarity analysis of the source contribution distributions was also conducted in this study. Results showed that the water environment in Jiangxi were considerably contaminated by trace metals (Cd, Cr, Co, Al, Mn, Cu, Zn and Ni). The concentrations of these trace metals in surface water demonstrated significant spatial variations and the ecological risk lay in high level. Mining activities were identified as the main anthropogenic sources, which should to be strictly regulated.


Assuntos
Metais Pesados , Poluentes do Solo , Oligoelementos , Metais Pesados/análise , Monitoramento Ambiental/métodos , Rios , China , Oligoelementos/análise , Medição de Risco , Poluentes do Solo/análise
16.
J Trace Elem Med Biol ; 75: 127108, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36435152

RESUMO

BACKGROUND: Most trace elements are inhibited by Helicobacter pylori-infection, and variations in specific element levels are linked to the development of stomach cancer. This is the first study to show the relationship between serum and tissue concentrations of twenty-five trace elements and H. pylori infection status. This study purposed to define serum and tissue trace element levels of 25 healthy individuals with Helicobacter pylori-positive gastritis and Helicobacter pylori-negative gastritis and to reveal their relationship with the disease. METHODS: Study groups consisted of sixty-two patients with Helicobacter pylori-positive, thirty-seven patients with Helicobacter pylori-negative, and thirty healthy individuals. Serum and tissue concentrations of twenty-five elements (aluminum, boron, arsenic, barium, calcium, beryllium, copper, cadmium, iron, chromium, mercury, lithium, potassium, magnesium, sodium, manganese, nickel, phosphorus, lead, scandium, strontium, selenium, tellurium, titanium, zinc) were defined by inductively coupled plasma optical emission spectrometry. RESULTS: Except for copper, lithium, and strontium elements in serum samples, other trace elements differed significantly between the groups (p < 0.05). The serum chromium (p = 0.002), mercury (p = 0.001), boron (p < 0.001), and cadmium (p < 0.001) levels of H. pylori-negative gastritis and H. pylori-positive gastritis participants were significantly different, and their serum concentrations were less than 0.5 µ/l. Boron, barium, beryllium, chromium, lithium, phosphorus and strontium elements in tissue samples did not differ significantly between the groups (p > 0.05). Manganese, nickel, tellurium and titanium elements were not detected in tissue and serum samples. The mean concentrations of calcium, beryllium, chromium, iron, potassium, lithium, magnesium, scandium, and selenium were higher in the tissues of patients with H. pylori gastritis compared to healthy control tissues. Also, cadmium could not be detected in tissue samples. There was a significant difference between H. pylori-infected tissue and serum chromium levels (p = 0.001), with lower levels detected in tissue samples. CONCLUSION: This is the first study that we are knowledgeable of that reports the concentrations of twenty five elements in both serum and tissue samples, as well as the relationship between trace elements and Helicobacter pylori-infection status. Dietary adjustment is indicated as an adjunct to medical therapy to stabilize trace elements because Helicobacter pylori bacteria cause inflammation and impair element absorption in gastritis patients. We also think that this study will shed light on studies on the relationship between Helicobacter pylori-trace elements and serum-tissue/healthy serum-tissue trace element levels of patients with Helicobacter pylori gastritis.


Assuntos
Helicobacter pylori , Mercúrio , Oligoelementos , Humanos , Magnésio , Manganês , Níquel , Cobre , Bário , Lítio , Cálcio , Titânio , Mucosa Gástrica , Cromo , Ferro , Potássio
17.
Ecotoxicol Environ Saf ; 249: 114424, 2023 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-36525945

RESUMO

Hydrogeochemical processes of trace elements (TEs) are of considerable significance to river water and groundwater resource assessment and utilization in the karst region. Therefore, seven TEs were analyzed to investigate their contents, spatial variations, sources, and controlling factors in Guiyang, a typical karst urban area in southwest China. The results showed that the average content of TEs in river water (e.g., As = 1.44 ± 0.47 µg/L andCo = 0.15 ± 0.06 µg/L) was higher than that of groundwater (e.g., As = 0.51 ± 0.42 µg/L andCo = 0.09 ± 0.05 µg/L). The types of groundwater samples were dominated by Ca/Mg-HCO3 and Ca/Mg-Cl types, while those of the river water samples were Ca-Cl and Ca/Mg-Cl types. Principal component analysis (PCA) and correlation analysis (CA) analyses indicated that As and Mn in the groundwater of the study area were related to river infiltration. The end-member analysis further revealed that river infiltration (As = 0.86-1.81 µg/L, Cl/SO42- = 0.62-0.89) and urban activities (As = 0.21-0.32 µg/L, Cl/SO42- = 0.51-0.89) were two main controlling factors of TEs (e.g., As, Co, and Mn) in the study area. In addition, the ion ratios in river and groundwater samples indicated that the weathering of carbonates was also an important control on the hydrogeochemistry of TEs (e.g., Fe and Mn) in Guiyang waters. This study showed that the trace element (TE) contents of groundwater in the Guiyang area were greatly associated with urban input and river recharge, and provided a new perspective for understanding the geochemical behavior of TEs in urban surface and groundwater bodies, which will help the protection of groundwater in the karst areas of southwest China.


Assuntos
Água Subterrânea , Oligoelementos , Poluentes Químicos da Água , Rios/química , Oligoelementos/análise , Monitoramento Ambiental , China , Carbonatos/análise , Água Subterrânea/química , Água/análise , Poluentes Químicos da Água/análise
18.
Ecotoxicol Environ Saf ; 249: 114436, 2023 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-36525951

RESUMO

The concentrations of trace elements in agricultural soils directly affect the ecological security and quality of agricultural products. A comprehensive study aimed at quantitatively analyze the effects of anthropogenic and natural environmental factors on the spatial distribution of heavy metals (HMs) and selenium (Se) in agricultural soils in a typical grain producing area of China. Factors considered in this study were parent rock, soil physicochemical properties, topography, precipitation, mine activity, and vegetation. Results showed that the median values of Zn, Cd, Cr, and Cu of 111 topsoil samples exceeded the background values of Guangxi province but were lower than the relevant national soil quality standards, and 85% of soil samples were classified as having rich Se levels (0.40 -3.0 mg kg-1). The potential ecological risk index of soil heavy metals as a whole was low, with Cd in 9% of the samples posing moderate ecological risk. The concentrations of heavy metals and Se were relatively high in soils from shale rock. Soil properties, mainly Fe2O3 and Mn played a dominant role on soil HMs and Se concentrations. Based on GeoDetector, we found that the interaction effects of two factors on the spatial differentiation of soil HMs and Se were greater than their sum effect. Among the factors, Mn enhanced the explanatory power of the model the most when interacting with other factors for soil Zn; the greatest interactive effect was between distance from mining area and Mn for Cd (q = 0.70); Fe2O3 significantly promoted the spatial differentiation of soil Cr, Cu and Se when interacting with other factors (q > 0.50). These findings contribute to a better understanding of the factors that drive the distribution of HMs and Se in agricultural soils.


Assuntos
Metais Pesados , Selênio , Poluentes do Solo , Oligoelementos , Solo/química , Oligoelementos/análise , Cádmio , Monitoramento Ambiental/métodos , China , Poluentes do Solo/análise , Medição de Risco , Metais Pesados/análise
19.
Environ Res ; 216(Pt 4): 114846, 2023 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-36402181

RESUMO

Some trace elements are established nephrotoxicants, yet their associations with kidney function remain understudied in the context of pregnancy, a time of substantial change in kidney physiology and function. We aimed to estimate the individual and joint associations of trace element mixtures with maternal kidney function during the 1st trimester of pregnancy (mean 9.7 gestational weeks). 1040 women from Project Viva contributed blood samples which were assessed for erythrocyte non-essential [arsenic (As), cadmium (Cd), cesium (Cs), mercury (Hg), lead (Pb)] and essential [barium (Ba), magnesium (Mg), manganese (Mn), selenium (Se), and Zinc (Zn)] trace elements, and plasma creatinine for kidney function. We estimated glomerular filtration rate using the Chronic Kidney Disease Epidemiology Collaboration (eGFRCKD-EPI) equation without race-adjustment factors. We examined associations of eGFRCKD-EPI with individual trace elements using multivariable linear regression and their mixtures using quantile-based g-computation, adjusting for sociodemographics, pregnancy characteristics, and diet. Participants in our study were predominantly White (75%), college graduates (72%), and had household income >$70,000/year (63%). After adjusting for covariates, higher Pb (ß -3.51 ml/min/1.73 m2; 95% CI -5.83, -1.18) concentrations were associated with lower eGFRCKD-EPI, while higher Mg (ß 10.53 ml/min/1.73 m2; 95% CI 5.35, 15.71), Se (ß 5.56 ml/min/1.73 m2; 95% CI 0.82, 10.31), and Zn (ß 5.88 ml/min/1.73 m2; 95% CI 0.51, 11.26) concentrations were associated with higher eGFRCKD-EPI. In mixture analyses, higher non-essential trace elements mixture concentration was associated with reduced eGFRCKD-EPI (Ψ -1.03 ml/min/1.73 m2; 95% CI: 1.92, -0.14). Conversely, higher essential trace elements mixture concentration was associated with higher eGFR (Ψ 1.42; 95% CI: 0.48, 2.37). Exposure to trace elements in early pregnancy may influence women's kidney function although reverse causation cannot be eliminated in this cross-sectional analysis. These findings have important implications for long-term cardiovascular and postpartum kidney health that warrant additional studies.


Assuntos
Mercúrio , Insuficiência Renal Crônica , Selênio , Oligoelementos , Gravidez , Feminino , Humanos , Estudos Transversais , Chumbo , Rim
20.
J Trace Elem Med Biol ; 75: 127086, 2023 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36215757

RESUMO

The heterogeneity properties shown by cells or unicellular organisms have led to the development of analytical methods at the single-cell level. In this sense, considering the importance of trace elements in these biological systems, the inductively coupled plasma mass spectrometer (ICP-MS) configured for analyzing single cell has presented a high potential to assess the evaluation of elements in cells. Moreover, advances in instrumentation, such as coupling laser ablation to the tandem configuration (ICP-MS/MS), or alternative mass analyzers (ICP-SFMS and ICP-TOFMS), brought significant benefits, including sensitivity improvement, high-resolution imaging, and the cell fingerprint. From this perspective, the single-cell ICP-MS has been widely reported in studies involving many fields, from oncology to environmental research. Hence, it has contributed to finding important results, such as elucidating nanoparticle toxicity at the cellular level and vaccine development. Therefore, in this review, the theory of single-cell ICP-MS analysis is explored, and the applications in this field are pointed out. In addition, the instrumentation advances for single-cell ICP-MS are addressed.


Assuntos
Oligoelementos , Espectrometria de Massas em Tandem
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