Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 1.174
Filtrar
3.
Jpn J Clin Oncol ; 50(5): 502-511, 2020 May 05.
Artigo em Inglês | MEDLINE | ID: mdl-32115625

RESUMO

The Japan Clinical Oncology Group Lung Cancer Study Group has been carrying out clinical studies, exploring new strategies of treatment, supportive therapies (antiemetics, etc.), etc., for a variety of cancers, including not only small cell lung cancer and non-small cell lung cancer but also rare chest tumours (represented by thymoma) and cancer-associated conditions (cancerous pericarditis, cancerous pleuritis, etc.). In this review, an overview of all studies conducted from 1985 to 2019 is provided.


Assuntos
Neoplasias Pulmonares/história , Oncologia/história , Carcinoma Pulmonar de Células não Pequenas/história , Carcinoma Pulmonar de Células não Pequenas/terapia , História do Século XX , História do Século XXI , Humanos , Japão , Neoplasias Pulmonares/terapia , Carcinoma de Pequenas Células do Pulmão/história , Carcinoma de Pequenas Células do Pulmão/terapia
6.
Cancer Metastasis Rev ; 38(3): 329, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31797176
7.
Exp Oncol ; 41(4): 368-369, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31868323

RESUMO

On December 1, 2019, the academic community commemorated the 120th birthday anniversary of Academician Rostislav Evgenievich Kavetsky, the famous oncologist and pathophysiologist, the founder of the Ukrainian school of experimental oncology, the organizer and the first director of the Institute that now bears his name.


Assuntos
Oncologia/história , Neoplasias , Academias e Institutos , Aniversários e Eventos Especiais , Pesquisa Biomédica/história , História do Século XX , História do Século XXI , Humanos , Neoplasias/história , Neoplasias/fisiopatologia , Ucrânia
8.
Nat Med ; 25(9): 1328, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31501594
13.
Commun Biol ; 2: 122, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31044157

RESUMO

Dr. Benjamin Bitler began his independent career at University of Colorado in January 2017. In this short Q&A he tells us about his motivation and passion for research, advice he would give to his younger self, and the attributes of cancer cells that he finds most perplexing.


Assuntos
Oncologia/história , Arizona , Colorado , Feminino , História do Século XX , História do Século XXI , Humanos , Motivação , Neoplasias Ovarianas/genética , Neoplasias Ovarianas/imunologia , Neoplasias Ovarianas/metabolismo , Philadelphia , Análise de Célula Única
16.
Cancer ; 125(14): 2345-2358, 2019 07 15.
Artigo em Inglês | MEDLINE | ID: mdl-30985918

RESUMO

During the period 1884 to 1922, the only option in cases of operable cancers was radical surgery, and only a minority of patients were cured. Sporadic attempts were made to treat inoperable cancer patients with bacterial toxins; however, with the discovery of x-ray and radium, the era of radiation treatment as an alternative to surgery began. The discovery of transmissible cancers and experimental growth of cancer cells offered new information and not only led to a better understanding of the cellular composition of cancers but also yielded important information that ultimately paved the way to chemotherapy. These efforts also advanced the understanding of the pathogenesis of tumors and induced new clinical and pathologic classifications and subspecializations. It is important to emphasize that many of the initiatives and discoveries made in Europe in the second half of the 19th century were first put into clinical practice in the United States during the first 2 decades of the 20th century, including the use of x-ray and radium for irradiation and as diagnostic tools. All things considered, the progress made between 1884 and 1922 came about through the hard work of many eminent individuals; however, there were 7 foresighted pathfinders (3 surgeons, 2 pathologists, 1 internist, and 1 physicist) who-despite their widely diverse backgrounds, personalities, and expertise-made remarkable contributions to oncology to an extent that is still felt today.


Assuntos
Oncologia/história , Oncologia/tendências , Sarcoma de Ewing/história , Anestesia Geral/história , Anestesia Local/história , Anti-Infecciosos Locais/história , Transfusão de Sangue/história , Europa (Continente) , História do Século XIX , História do Século XX , Humanos , Microscopia/história , Microscopia/instrumentação , Radiologia/história , Radiologia/instrumentação , Suturas/história , Medicamentos Sintéticos/história , Estados Unidos
17.
Med Hypotheses ; 126: 109-128, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31010487

RESUMO

Unlike other carcinomas, hepatocellular carcinoma (HCC) metastasizes to distant organs relatively rarely. In contrast, it routinely metastasizes to liver vasculature/liver, affecting portal veins 3-10 times more often than hepatic veins. This portal metastatic predominance is traditionally rationalized within the model of a reverse portal flow, due to accompanying liver cirrhosis. However, this intuitive model is not coherent with facts: 1) reverse portal flow occurs in fewer than 10% of cirrhotic patients, while portal metastasis occurs in 30-100% of HCC cases, and 2) portal vein prevalence of HCC metastasis is also characteristic of HCC in non-cirrhotic livers. Therefore, we must assume that the route for HCC metastatic dissemination is the same as for other carcinomas: systemic dissemination via the draining vessel, i.e., via the hepatic vein. In this light, portal prevalence versus hepatic vein of HCC metastasis appears as a puzzling pattern, particularly in cases when portal HCC metastases have appeared as the sole manifestation of HCC. Considering that other GI carcinomas (colorectal, pancreatic, gastric and small bowel) invariably disseminate via portal vein, but very rarely form portal metastasis, portal prevalence of HCC metastasis appears as a paradox. However, nature does not contradict itself; it is rather our wrong assumptions that create paradoxes. The 'portal paradox' becomes a logical event within the hypothesis that the formation of the unique portal venous system preceded the appearance of liver in evolution of chordates. The analysis suggests that the appearance of the portal venous system, supplying hormones and growth factors of pancreatic family, which includes insulin, glucagon, somatostatin, and pancreatic polypeptide (HGFPF) to midgut diverticulum in the early evolution of chordates (in an Amphioxus-like ancestral animal), promoted differentiation of enterocytes into hepatocytes and their further evolution to the liver of vertebrates. These promotional-dependent interactions are conserved in the vertebrate lineage. I hypothesize that selective homing and proliferation of malignant hepatocytes (i.e., HCC cells) in the portal vein environment are due to a uniquely high concentration of HGFPF in portal blood. HGFPF are also necessary for liver function and renewal and are significantly extracted by hepatocytes from passing blood, creating a concentration gradient of HGFPF between the portal blood and hepatic vein outflow, making post-liver vasculature and remote organs less favorable spaces for HCC growth. It also suggested that the portal vein environment (i.e., HGFPF) promotes the differentiation of more aggressive HCC clones from already-seeded portal metastases, explaining the worse outcome of HCC with the portal metastatic pattern. The analysis also offers new hypothesis on the phylogenetic origin of the hepatic diverticulum of cephalochordates, with certain implications for the modeling of the chordate phylogeny.


Assuntos
Evolução Biológica , Carcinoma Hepatocelular/irrigação sanguínea , Carcinoma Hepatocelular/patologia , Veias Hepáticas/patologia , Neoplasias Hepáticas/irrigação sanguínea , Neoplasias Hepáticas/patologia , Veia Porta/patologia , Animais , Hepatócitos/patologia , História do Século XIX , História do Século XX , Humanos , Anfioxos , Fígado/patologia , Cirrose Hepática/patologia , Neoplasias Hepáticas/secundário , Oncologia/história , Modelos Anatômicos , Modelos Biológicos , Metástase Neoplásica , Obstetrícia/história , Filogenia , Ratos
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA