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1.
Int J Mol Sci ; 22(12)2021 Jun 11.
Artigo em Inglês | MEDLINE | ID: mdl-34207956

RESUMO

This review is a survey of recent advances in studies concerning the impact of poly- and perfluorinated organic compounds in aquatic organisms. After a brief introduction on poly- and perfluorinated compounds (PFCs) features, an overview of recent monitoring studies is reported illustrating ranges of recorded concentrations in water, sediments, and species. Besides presenting general concepts defining bioaccumulative potential and its indicators, the biodistribution of PFCs is described taking in consideration different tissues/organs of the investigated species as well as differences between studies in the wild or under controlled laboratory conditions. The potential use of species as bioindicators for biomonitoring studies are discussed and data are summarized in a table reporting the number of monitored PFCs and their total concentration as a function of investigated species. Moreover, biomolecular effects on taxonomically different species are illustrated. In the final paragraph, main findings have been summarized and possible solutions to environmental threats posed by PFCs in the aquatic environment are discussed.


Assuntos
Organismos Aquáticos/metabolismo , Bioacumulação , Monitoramento Biológico , Fluorcarbonetos/metabolismo , Meia-Vida , Distribuição Tecidual
2.
Chemosphere ; 279: 130470, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34134398

RESUMO

Methylmercury concentrations vary widely across geographic space and among habitat types, with marine and aquatic-feeding organisms typically exhibiting higher mercury concentrations than terrestrial-feeding organisms. However, there are few model organisms to directly compare mercury concentrations as a result of foraging in marine, estuarine, or terrestrial food webs. The ecological impacts of differential foraging may be especially important for generalist species that exhibit high plasticity in foraging habitats, locations, or diet. Here, we investigate whether foraging habitat, sex, or fidelity to a foraging area impact blood mercury concentrations in western gulls (Larus occidentalis) from three colonies on the US west coast. Cluster analyses showed that nearly 70% of western gulls foraged primarily in ocean or coastal habitats, whereas the remaining gulls foraged in terrestrial and freshwater habitats. Gulls that foraged in ocean or coastal habitats for half or more of their foraging locations had 55% higher mercury concentrations than gulls that forage in freshwater and terrestrial habitats. Ocean-foraging gulls also had lower fidelity to a specific foraging area than freshwater and terrestrial-foraging gulls, but fidelity and sex were unrelated to gull blood mercury concentrations in all models. These findings support existing research that has described elevated mercury levels in species using aquatic habitats. Our analyses also demonstrate that gulls can be used to detect differences in contaminant exposure over broad geographic scales and across coarse habitat types, a factor that may influence gull health and persistence of other populations that forage across the land-sea gradient.


Assuntos
Charadriiformes , Mercúrio , Animais , Organismos Aquáticos , Ecossistema , Cadeia Alimentar
3.
Sci Total Environ ; 788: 147868, 2021 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-34134389

RESUMO

The threat posed by invasive non-native species worldwide requires a global approach to identify which introduced species are likely to pose an elevated risk of impact to native species and ecosystems. To inform policy, stakeholders and management decisions on global threats to aquatic ecosystems, 195 assessors representing 120 risk assessment areas across all six inhabited continents screened 819 non-native species from 15 groups of aquatic organisms (freshwater, brackish, marine plants and animals) using the Aquatic Species Invasiveness Screening Kit. This multi-lingual decision-support tool for the risk screening of aquatic organisms provides assessors with risk scores for a species under current and future climate change conditions that, following a statistically based calibration, permits the accurate classification of species into high-, medium- and low-risk categories under current and predicted climate conditions. The 1730 screenings undertaken encompassed wide geographical areas (regions, political entities, parts thereof, water bodies, river basins, lake drainage basins, and marine regions), which permitted thresholds to be identified for almost all aquatic organismal groups screened as well as for tropical, temperate and continental climate classes, and for tropical and temperate marine ecoregions. In total, 33 species were identified as posing a 'very high risk' of being or becoming invasive, and the scores of several of these species under current climate increased under future climate conditions, primarily due to their wide thermal tolerances. The risk thresholds determined for taxonomic groups and climate zones provide a basis against which area-specific or climate-based calibrated thresholds may be interpreted. In turn, the risk rankings help decision-makers identify which species require an immediate 'rapid' management action (e.g. eradication, control) to avoid or mitigate adverse impacts, which require a full risk assessment, and which are to be restricted or banned with regard to importation and/or sale as ornamental or aquarium/fishery enhancement.


Assuntos
Ecossistema , Espécies Introduzidas , Animais , Organismos Aquáticos , Mudança Climática , Água Doce
4.
Ecotoxicol Environ Saf ; 220: 112405, 2021 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-34130182

RESUMO

Hazardous substances, such as microcystin-LR (MC-LR) and phenanthrene (Phe) are ubiquitous co-contaminants in eutrophic freshwaters, which cause harms to aquatic organisms. However, the risks associated with the co-exposure of aquatic biota to these two chemicals in the environment have received little attention. In this study, the single and mixture toxic effects of MC-LR and Phe mixtures were investigated in Daphnia magna after acute and chronic exposure. Acute tests showed that the median effective concentrations (48 h) for MC-LR, Phe and their mixtures were 13.46, 0.57 and 8.84 mg/L, respectively. Mixture toxicity prediction results indicated that the independent action model was more applicable than the concentration addition model. Moreover, combination index method suggested that the mixture toxicity was concentration dependent. Synergism was elicited at low concentrations of MC-LR and Phe exposure (≤4.04 + 0.17 mg/L), whereas antagonistic or additive effects were induced at higher concentrations. The involved mechanism of antagonism was presumably attributable to the protective effects of detoxification genes activated by high concentrations of MC-LR in mixtures. Additionally, chronic results also showed that exposure to a MC-LR and Phe mixture at low concentrations (≤50 +2 µg/L) resulted in greater toxic effects on D. magna life history than either chemical acting alone. The significant inhibition on detoxification genes and increased accumulation of MC-LR could be accounted for their synergistic toxic effects on D. magna. Our findings revealed the exacerbated ecological hazard of MC-LR and Phe at environmental concentrations (≤50 +2 µg/L), and provided new insights to the potential toxic mechanisms of MC-LR and Phe in aquatic animals.


Assuntos
Daphnia/efeitos dos fármacos , Toxinas Marinhas/toxicidade , Microcistinas/toxicidade , Fenantrenos/toxicidade , Poluentes Químicos da Água/toxicidade , Animais , Organismos Aquáticos/efeitos dos fármacos , Daphnia/genética , Daphnia/crescimento & desenvolvimento , Daphnia/metabolismo , Interações Medicamentosas , Água Doce/química , Inativação Metabólica/efeitos dos fármacos , Inativação Metabólica/genética , Estágios do Ciclo de Vida/efeitos dos fármacos , Toxinas Marinhas/análise , Microcistinas/análise , Fenantrenos/análise
5.
Sci Total Environ ; 783: 147076, 2021 Aug 20.
Artigo em Inglês | MEDLINE | ID: mdl-34088154

RESUMO

Microplastics (MPs) attract global concern due to their ubiquitous existence in aquatic environments. However, the genotoxic effect of MPs on aquatic organisms in the natural environment remains controversial. Therefore, this meta-analysis was conducted by recompiling 44 individual studies from 12 publications to determine whether MPs could induce genotoxicity in aquatic organisms at environmentally relevant concentrations (≤1 mg/L, median = 0.5 mg/L). Multiple genotoxic endpoints were involved, including the percentage of DNA in tail (TDNA%), tail length (TL), olive tail moment (OTM), and the number of micronuclei (NM), and their increases represented the biologically adverse effects (i.e. genotoxicity). The results showed that all included endpoints tended to increase after exposure to MPs, among which TDNA%, TL and NM were significantly increased by 20%, 32% and 81% compared with the control group, respectively. The overall estimate of all endpoints in the MPs-treated groups was remarkably increased by 24%, with high statistical power and no obvious publication bias, suggesting the evident genotoxicity caused by MPs. In addition, the magnitudes of MPs-induced genotoxicity were independent of selected endpoint, MP composition, morphology, exposure concentration and duration, but closely correlated with particle size, living habitat and tested species. Overall, this work provided a reference for the health risk assessment of MPs in the natural environment, contributing to our understanding the action mode of MPs at environmentally relevant concentrations.


Assuntos
Microplásticos , Poluentes Químicos da Água , Organismos Aquáticos , Dano ao DNA , Plásticos/toxicidade , Poluentes Químicos da Água/análise , Poluentes Químicos da Água/toxicidade
6.
Molecules ; 26(10)2021 May 13.
Artigo em Inglês | MEDLINE | ID: mdl-34068079

RESUMO

Noble metals nanoparticles (NPs) and metal oxide NPs are widely used in different fields of application and commercial products, exposing living organisms to their potential adverse effects. Recent evidences suggest their presence in the aquifers water and consequently in drinking water. In this work, we have carefully synthesized four types of NPs, namely, silver and gold NPs (Ag NPs and Au NPs) and silica and titanium dioxide NPs (SiO2 NPs and TiO2 NPs) having a similar size and negatively charged surfaces. The synthesis of Ag NPs and Au NPs was carried out by colloidal route using silver nitrate (AgNO3) and tetrachloroauric (III) acid (HAuCl4) while SiO2 NPs and TiO2 NPs were achieved by ternary microemulsion and sol-gel routes, respectively. Once the characterization of NPs was carried out in order to assess their physico-chemical properties, their impact on living cells was studied. We used the human colorectal adenocarcinoma cells (Caco-2), known as the best representative intestinal epithelial barrier model to understand the effects triggered by NPs through ingestion. Then, we moved to explore how water contamination caused by NPs can be lowered by the ability of three species of aquatic moss, namely, Leptodictyum riparium, Vesicularia ferriei, and Taxiphyllum barbieri, to absorb them. The experiments were conducted using two concentrations of NPs (100 µM and 500 Μm as metal content) and two time points (24 h and 48 h), showing a capture rate dependent on the moss species and NPs type. Then, the selected moss species, able to actively capture NPs, appear as a powerful tool capable to purify water from nanostructured materials, and then, to reduce the toxicity associated to the ingestion of contaminated drinking water.


Assuntos
Absorção Fisico-Química , Organismos Aquáticos/metabolismo , Briófitas/metabolismo , Fenômenos Químicos , Compostos Inorgânicos/química , Mucosa Intestinal/efeitos dos fármacos , Nanopartículas Metálicas/toxicidade , Modelos Biológicos , Organismos Aquáticos/efeitos dos fármacos , Briófitas/efeitos dos fármacos , Células CACO-2 , Morte Celular/efeitos dos fármacos , Sobrevivência Celular/efeitos dos fármacos , Difusão Dinâmica da Luz , Células Germinativas Vegetais/efeitos dos fármacos , Humanos , Nanopartículas Metálicas/química , Nanopartículas Metálicas/ultraestrutura , Espectrofotometria Ultravioleta , Eletricidade Estática , Titânio/química , Titânio/toxicidade , Difração de Raios X
7.
Int J Mol Sci ; 22(11)2021 May 31.
Artigo em Inglês | MEDLINE | ID: mdl-34072783

RESUMO

Marine mammals have been described as sentinels of the health of marine ecosystems. Therefore, the aim of this study was to investigate (i) the presence of extended-spectrum ß-lactamase (ESBL)- and AmpC-producing Enterobacterales, which comprise several bacterial families important to the healthcare sector, as well as (ii) the presence of Salmonella in these coastal animals. The antimicrobial resistance pheno- and genotypes, as well as biocide susceptibility of Enterobacterales isolated from stranded marine mammals, were determined prior to their rehabilitation. All E. coli isolates (n = 27) were screened for virulence genes via DNA-based microarray, and twelve selected E. coli isolates were analyzed by whole-genome sequencing. Seventy-one percent of the Enterobacterales isolates exhibited a multidrug-resistant (MDR) pheno- and genotype. The gene blaCMY (n = 51) was the predominant ß-lactamase gene. In addition, blaTEM-1 (n = 38), blaSHV-33 (n = 8), blaCTX-M-15 (n = 7), blaOXA-1 (n = 7), blaSHV-11 (n = 3), and blaDHA-1 (n = 2) were detected. The most prevalent non-ß-lactamase genes were sul2 (n = 38), strA (n = 34), strB (n = 34), and tet(A) (n = 34). Escherichia coli isolates belonging to the pandemic sequence types (STs) ST38, ST167, and ST648 were identified. Among Salmonella isolates (n = 18), S. Havana was the most prevalent serotype. The present study revealed a high prevalence of MDR bacteria and the presence of pandemic high-risk clones, both of which are indicators of anthropogenic antimicrobial pollution, in marine mammals.


Assuntos
Organismos Aquáticos/microbiologia , Enterobacter/enzimologia , Mamíferos/microbiologia , Salmonella/enzimologia , beta-Lactamases/biossíntese , Animais , Antibacterianos/farmacologia , Proteínas de Bactérias/genética , Técnicas de Tipagem Bacteriana , Farmacorresistência Bacteriana , Enterobacter/efeitos dos fármacos , Enterobacter/genética , Enterobacter/isolamento & purificação , Genótipo , Testes de Sensibilidade Microbiana , Salmonella/efeitos dos fármacos , Salmonella/genética , Salmonella/isolamento & purificação , Fatores de Virulência/genética , beta-Lactamases/genética
8.
Molecules ; 26(9)2021 May 05.
Artigo em Inglês | MEDLINE | ID: mdl-34063013

RESUMO

Marine organisms are able to produce a plethora of small molecules with novel chemical structures and potent biological properties, being a fertile source for discovery of pharmacologically active compounds, already with several marine-derived agents approved as drugs. Glioma is classified by the WHO as the most common and aggressive form of tumor on CNS. Currently, Temozolomide is the only chemotherapeutic option approved by the FDA even though having some limitations. This review presents, for the first time, a comprehensive overview of marine compounds described as anti-glioma agents in the last decade. Nearly fifty compounds were compiled in this document and organized accordingly to their marine sources. Highlights on the mechanism of action and ADME properties were included. Some of these marine compounds could be promising leads for the discovery of new therapeutic alternatives for glioma treatment.


Assuntos
Antineoplásicos/uso terapêutico , Organismos Aquáticos/química , Glioma/tratamento farmacológico , Bibliotecas de Moléculas Pequenas/uso terapêutico , Animais , Antineoplásicos/química , Antineoplásicos/farmacocinética , Antineoplásicos/farmacologia , Glioma/patologia , Humanos , Nanotecnologia , Bibliotecas de Moléculas Pequenas/química , Bibliotecas de Moléculas Pequenas/farmacocinética , Bibliotecas de Moléculas Pequenas/farmacologia
9.
Molecules ; 26(9)2021 May 07.
Artigo em Inglês | MEDLINE | ID: mdl-34067123

RESUMO

Marine actinomycetes, Streptomyces species, produce a variety of halogenated compounds with diverse structures and a range of biological activities owing to their unique metabolic pathways. These halogenated compounds could be classified as polyketides, alkaloids (nitrogen-containing compounds) and terpenoids. Halogenated compounds from marine actinomycetes possess important biological properties such as antibacterial and anticancer activities. This review reports the sources, chemical structures and biological activities of 127 new halogenated compounds originated mainly from Streptomyces reported from 1992 to 2020.


Assuntos
Actinobacteria/química , Organismos Aquáticos/química , Halogênios/isolamento & purificação , Halogênios/química , Especificidade da Espécie
10.
Ecotoxicol Environ Saf ; 220: 112360, 2021 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-34058680

RESUMO

Recently, emerging pollutants, such as anthelmintics have attracted an increasing attention worldwide due to their extensive use and notable stability. However, the information on anthelmintics in the environment of southwest China is scarce. Thus, the occurrence, ecological risk and exposure evaluation of nineteen anthelmintics in Tuojiang River, which is one of the largest tributaries of Yangtze River, and drinking water source of Sichuan, southwest China, were investigated. The result showed that the detection frequency of anthelmintics was relatively high in Tuojiang River, ranging from 65% to 100% in river water. Among the seven kinds of anthelmintics, benzimidazoles are the primary anthelmintics, with concentrations up to 61.12 ng/L and 596.06 ng/g in water and sediment of the Tuojiang river, respectively. The total concentration of 19 anthelmintics in sediment samples from non-agricultural area was higher than that in agricultural area(p = 0.000 < 0.05). This could be attributed to anthropogenic activities, which lead to greater discharge and accumulation of anthelmintics in residential area along the river. It's worth to mention that the highest total concentrations of anthelmintics (109.28 ng/L) was found at the junction of rivers in R31 site. The results could be ascribed to the complexity of junction of Tuojiang River and Yangtze River, which could influence the distribution of pollutant. Besides, the ecological risk assessment showed that the macrocyclic lactones rather than benzimidazoles had relatively high toxicity to non-target organisms in aquatic environment (p = 0.000 < 0.05), with the highest RQEcotox value of 101 for Daphnia magna, while benzimidazoles had relatively high concentrations. The exposure risk could be ignored for both children and adults because the daily intake of anthelmintics via water ingestion were below 10 ng/kg/d. In addition, strong correlations were found between sucralose and most of the selected anthelmintics in Tuojiang River, indicating that sucralose might be a good tracer to evaluated the source of anthelmintics in surface water. This study provides the levels, risks and even some tracer information of pollutants for better understanding of anthelmintics in southwest China.


Assuntos
Anti-Helmínticos/análise , Exposição Ambiental/análise , Rios/química , Poluentes Químicos da Água/análise , Adulto , Animais , Anti-Helmínticos/toxicidade , Organismos Aquáticos/efeitos dos fármacos , Criança , China , Daphnia/efeitos dos fármacos , Sedimentos Geológicos/química , Humanos , Medição de Risco , Sacarose/análogos & derivados , Sacarose/análise , Poluentes Químicos da Água/toxicidade
11.
Food Res Int ; 143: 110313, 2021 05.
Artigo em Inglês | MEDLINE | ID: mdl-33992332

RESUMO

Marine organisms have received mounting attention in antiaging activity due to their exclusive chemicals. This review aims at revealing and discussing prospective antiaging substance from marine macroalgae, micaroalgae, invertebrate and vertebrate. The activity and mechanism of the carbohydrate, protein, pigment, flavonoids, fatty acids, phenols from marine organisms were revealed through a variety of antiaging experimental models such as rats, Drosophila melanogaster and Caenorhabditis elegans. And meanwhile, the problems and prospects aspects were discussed for future research in this field. It was suggested that the antiaging functional ingredients from these marine organisms are alternative sources for synthetic ingredients that can contribute to consumer's well-being, as part of nutraceuticals, functional foods and cosmetics.


Assuntos
Organismos Aquáticos , Drosophila melanogaster , Animais , Suplementos Nutricionais , Alimento Funcional , Estudos Prospectivos , Ratos
12.
Environ Res ; 199: 111418, 2021 08.
Artigo em Inglês | MEDLINE | ID: mdl-34052244

RESUMO

Riverine bacterioplankton are highly responsive to river alterations and their abundant and rare sub-communities may have different roles in biogeochemical cycling. However, with the rapid development of dam constructions, our knowledge on adaptation mechanism of these sub-communities in regulated river ecosystem was still limited, especially with regard to their functional traits. Here, our study was conducted in the 2800 km Yarlung Tsangpo River on the Tibetan Plateau to address the question of how abundant and rare bacterioplankton would respond taxonomically and functionally to river damming using 16S rRNA gene sequencing combined with Geochip microarray technique. Our results showed that abundant sub-community dominated taxonomic composition while rare sub-community largely determined functional composition. It is also observed that taxonomic diversity of abundant sub-community was significantly stimulated in the reservoir while that of rare sub-community was markedly inhibited. Moreover, abundant sub-community exhibited functional redundancy under damming disturbances since altered taxonomic composition and unaltered functional composition co-occurred simultaneously. Meanwhile, due to portfolio effect, rare sub-community maintained a greater stability under damming disturbances with little variation in taxonomic and functional compositions. In addition, the Stegen null model analysis revealed that stochastic process governed community assembly in both abundant and rare sub-communities. However, according to source tracking analysis, the taxonomic dispersion of abundant sub-community was less significantly impeded by the dam while the functional dispersion of rare sub-community was less strongly interrupted, indicating that the dispersal process in the dominated sub-community was less susceptible to damming. Therefore, by considering bacterioplankton functional traits, our study provided comprehensive evidences for the distinct strategies of abundant and rare sub-communities in response to damming.


Assuntos
Ecossistema , Rios , Organismos Aquáticos , China , RNA Ribossômico 16S/genética
13.
Mar Environ Res ; 169: 105371, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-34044285

RESUMO

It is important to study the fitness of marine invertebrates in exposure to high water temperature. We studied whether the long-term high temperatures work on the fitness-related traits (righting behavior, covering behavior, foraging behavior, Aristotle's lantern reflex, body size) of S. intermedius whose parents (males and females) were exposed to ambient or high temperatures (~3 °C higher than the ambient) for a long period of time. The present study found that test diameter, wet body weight and test weight of offspring were not significantly different between temperature treatments, indicating that the parental sea urchins in exposure to high temperatures develop no carryover effects on the body size of the offspring sea urchins. We found no significant difference in foraging behavior, Aristotle's lantern reflex, lantern length and lantern weight of sea urchins after their parents had experienced long-term high temperatures. In addition, no significant change was found in the righting and covering behaviors of sea urchins whose parents were at long-term high temperatures. These results indicate that no significant lasting effects exhibited in the fitness-related behaviors and tissue size after their parents were exposed to high temperatures for a long time. The crushing force of test and test thickness showed no significant difference in the offspring of S. intermedius, no matter whether their parents were exposed to long-term high temperatures or not. The current results enrich our understanding that the parental sea urchin experiencing long-term high temperatures probably develop no carryover effects on the test of their offspring. We found that sea urchins whose parents were exposed to long-term elevated temperatures showed a significantly higher lantern length/test diameter and a significantly lower test height/test diameter in offspring sea urchins due to the thermal experience of their parents, showing the plasticity of lantern and test of offspring sea urchins in response to the thermal experience of their parents. Together with our previous investigation, the present study indicates that small sea urchins are less susceptible to the carryover effects of high temperatures in comparison with the developmental stages of embryos and larvae.


Assuntos
Strongylocentrotus , Animais , Organismos Aquáticos , Feminino , Masculino , Fenótipo , Ouriços-do-Mar , Temperatura , Água
14.
Sci Total Environ ; 785: 147286, 2021 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-33932676

RESUMO

Epibiotic bacterial community colonized on the plant leaf plays important roles in promoting plant growth and nutrient absorption, but is sensitive to environmental changes. As one of the most important environmental factors affecting the growth of plants and photosynthetic microorganisms, light may affect the diversity, composition, and interactions of the epibiotic bacterial community. Submerged plants in the aquatic ecosystem may be more sensitive to light intensity variations compared to the terrestrial plants since they usually receive less light. However, the effects of light on the interactions between the submerged plants and their epibiotic microbial communities remain uncertain. Here we used the 16S rRNA gene high-throughput sequencing to investigate the diversity and composition of the bacterioplankton and epibiotic bacterial communities of the Cabomba caroliniana under four different shading levels. A total of 24 water and leaf samples were collected from the experimental microcosms near Lake Taihu. We found the epibiotic bacterial community possessed a higher diversity than that of the bacterioplankton community, although the alpha diversity of the bacterioplankton community was more susceptible to different levels of shading. SourceTracker analysis revealed that with the increase of shading, the colonization of bacterioplankton to epibiotic bacteria decreased. Network analysis showed that the bacterial community network at 50% shading level had the lowest modularity and highest clustering coefficient compared to the bacterial community networks of other shading levels. Our findings provided new understandings of the effects of different light intensities on the epibiotic bacterial communities of submerged macrophytes.


Assuntos
Ecossistema , Microbiota , Organismos Aquáticos , Bactérias/genética , Lagos , Plâncton , RNA Ribossômico 16S/genética
15.
J Hazard Mater ; 412: 125028, 2021 06 15.
Artigo em Inglês | MEDLINE | ID: mdl-33951853

RESUMO

Cyclophosphamide (CP) and Cisplatin (CDDP) are antineoplastic drugs widely used in the treatment of neoplastic diseases that have been detected in the aquatic environment. This review summarizes the current knowledge on the presence in the aquatic environment of these two drugs and their effects on freshwater and marine invertebrates, which includes good model species in ecotoxicology and risk assessment programs. The consumption levels, occurrence in freshwater and marine ecosystems, and the impacts exerted on aquatic organisms, even at low concentrations, justifies this review and the selection of these two drugs. Both pharmaceuticals were detected in different aquatic environments, with concentrations ranging from ng L-1 up to 687.0 µg L-1 (CP) and 250 µg L-1 (CDDP). The available studies showed that CP and CDDP induce individual and sub-individual impacts on aquatic invertebrate species. The most common effects reported were changes in the reproductive function, oxidative stress, genotoxicity, cytotoxicity and neurotoxicity. The literature used in this review supports the need to increase monitoring studies concerning the occurrence of antineoplastic drugs in the aquatic environment since negative effects have been reported even at trace concentrations (ng L-1). Furthermore, marine ecosystems should be considered as a priority since less is known on the occurrence and effects of antineoplastic drugs in this environment comparing to freshwater ecosystems.


Assuntos
Antineoplásicos , Poluentes Químicos da Água , Animais , Antineoplásicos/toxicidade , Organismos Aquáticos , Cisplatino/toxicidade , Ciclofosfamida/toxicidade , Ecossistema , Poluentes Químicos da Água/análise , Poluentes Químicos da Água/toxicidade
16.
Sci Total Environ ; 787: 147529, 2021 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-33991914

RESUMO

Isoflucypram belongs to the new generation of succinate dehydrogenase inhibitor (SDHI) fungicides that are commonly used in crop fungal disease control. Evidence indicates that isoflucypram poses a potential risk to aquatic organisms. However, the effects of isoflucypram during early embryogenesis are not fully understood. In the present study, zebrafish embryos were exposed to 0.025, 0.25, or 2.5 µM isoflucypram for three days. Isoflucypram caused severe developmental abnormalities (yolk sac edema, pericardial edema, and blood clotting clustering), hatching delay, and decreased heart rates in zebrafish. The expression levels of cardiac-specific genes (nkx2.5, myh7, myl7, and myh6) and erythropoiesis-related genes (gata1a, hbbe1, hbbe2, and alas2) were disrupted after isoflucypram exposure. Furthermore, enrichment analysis indicated that most of the differentially expressed genes (DEGs) were enriched in heart development or hemopoiesis processes. Overall, these findings suggest that exposure to isoflucypram is associated with developmental and cardiovascular toxicity in zebrafish.


Assuntos
Fungicidas Industriais , Poluentes Químicos da Água , Animais , Organismos Aquáticos , Embrião não Mamífero , Desenvolvimento Embrionário , Fungicidas Industriais/toxicidade , Poluentes Químicos da Água/análise , Peixe-Zebra
17.
Sci Total Environ ; 787: 147590, 2021 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-33991923

RESUMO

The concentration of dissolved organic matter (DOM) in aquatic ecosystems has manifold direct and indirect consequences for primary and secondary production. Theoretical approaches suggest a negative effect of DOM on phytoplankton and a positive effect on bacteria, both of which alter the development of metazooplankton, the main consumer of bacteria and phytoplankton. However, experimental observations give heterogeneous results on the effect sizes of plankton in relation to DOM addition. Here, the synthesis of 411 effect sizes of plankton in response to DOM is presented from 59 studies. The referenced studies display effect sizes in relation to various DOM sources and different experimental designs. Thus, the hypothesis that neither DOM quality nor the type of experiment bias the effect size response of plankton was tested; the hypothesis was tested separately for bacterioplankton, phytoplankton and metazooplankton with the use of a meta-analytical approach. DOM quality was represented by the five different sources of DOM that are used most often in these experiments, i.e., natural water, bog leachate, glucose/sucrose, terrestrial plant leachate, and soil leachate. The experiment types comprised in situ experiments, i.e., experiments taking place under manipulated conditions in a natural ecosystem, and ex situ experiments, i.e., those taking place outside of a natural ecosystem. The meta-analyses showed that, although total DOM had a positive influence on the effect size of bacterioplankton and an insignificant influence on metazooplankton, the effect sizes differed significantly in relation to DOM source and the type of experiment. The effect size of phytoplankton, although not significantly related with total DOM, differed in response to DOM source but not experiment type. The results suggest that experimental conditions may produce artifacts in the strength of responses of aquatic biota to DOM concentrations.


Assuntos
Ecossistema , Plâncton , Organismos Aquáticos , Água Doce , Fitoplâncton
18.
Mar Pollut Bull ; 168: 112438, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-33991983

RESUMO

Plastic pollution in the ocean is an increasingly detrimental issue for marine organisms. As a form of polarized light pollution, transparent plastic debris may be more visible and pose additional threats to organisms that can detect and interpret polarized light. Plastic can mimic the visual features of common marine prey items, such as transparent gelatinous zooplankton, which may lead to more significant plastic ingestion. We measured, in situ, the polarization and radiance contrast between a transparent plastic bag and gelatinous zooplankton with an underwater video polarimeter. The plastic bag had significantly higher polarization contrast than the gelatinous zooplankton, yet both shared similar radiance contrasts. This higher polarization contrast may contribute to the observed high ingestion rates of transparent plastic by marine organisms. Further study into the connection between polarization-sensitive organisms and plastic ingestion is recommended.


Assuntos
Gelatina , Zooplâncton , Animais , Organismos Aquáticos , Ingestão de Alimentos , Monitoramento Ambiental , Plásticos
19.
Mar Drugs ; 19(5)2021 Apr 29.
Artigo em Inglês | MEDLINE | ID: mdl-33946845

RESUMO

Catheter-associated urinary tract infections (CAUTIs) are among the leading nosocomial infections in the world and have led to the extensive study of various strategies to prevent infection. However, despite an abundance of anti-infection materials having been studied over the last forty-five years, only a few types have come into clinical use, providing an insignificant reduction in CAUTIs. In recent decades, marine resources have emerged as an unexplored area of opportunity offering huge potential in discovering novel bioactive materials to combat human diseases. Some of these materials, such as antimicrobial compounds and biosurfactants synthesized by marine microorganisms, exhibit potent antimicrobial, antiadhesive and antibiofilm activity against a broad spectrum of uropathogens (including multidrug-resistant pathogens) that could be potentially used in urinary catheters to eradicate CAUTIs. This paper summarizes information on the most relevant materials that have been obtained from marine-derived microorganisms over the last decade and discusses their potential as new agents against CAUTIs, providing a prospective proposal for researchers.


Assuntos
Antibacterianos/farmacologia , Organismos Aquáticos/metabolismo , Bactérias/efeitos dos fármacos , Infecções Relacionadas a Cateter/tratamento farmacológico , Cateteres de Demora/microbiologia , Infecção Hospitalar/tratamento farmacológico , Tensoativos/farmacologia , Cateterismo Urinário/instrumentação , Cateteres Urinários/microbiologia , Animais , Antibacterianos/isolamento & purificação , Bactérias/crescimento & desenvolvimento , Biofilmes/efeitos dos fármacos , Biofilmes/crescimento & desenvolvimento , Infecções Relacionadas a Cateter/diagnóstico , Infecções Relacionadas a Cateter/microbiologia , Cateteres de Demora/efeitos adversos , Infecção Hospitalar/diagnóstico , Infecção Hospitalar/microbiologia , Desenho de Equipamento , Humanos , Metabolismo Secundário , Propriedades de Superfície , Tensoativos/isolamento & purificação , Cateterismo Urinário/efeitos adversos , Cateteres Urinários/efeitos adversos
20.
Mar Drugs ; 19(5)2021 Apr 29.
Artigo em Inglês | MEDLINE | ID: mdl-33947080

RESUMO

Marine polycyclic ether natural products have gained significant interest from the chemical community due to their impressively huge molecular architecture and diverse biological functions. The structure assignment of this class of extraordinarily complex natural products has mainly relied on NMR spectroscopic analysis. However, NMR spectroscopic analysis has its own limitations, including configurational assignment of stereogenic centers within conformationally flexible systems. Chemical shift deviation analysis of synthetic model compounds is a reliable means to assign the relative configuration of "difficult" stereogenic centers. The complete configurational assignment must be ultimately established through total synthesis. The aim of this review is to summarize the indispensable role of organic synthesis in stereochemical assignment of marine polycyclic ethers.


Assuntos
Organismos Aquáticos/metabolismo , Éteres Cíclicos/síntese química , Técnicas de Química Sintética , Ciguatoxinas/síntese química , Ciguatoxinas/isolamento & purificação , Éteres/síntese química , Éteres/isolamento & purificação , Éteres Cíclicos/isolamento & purificação , Humanos , Espectroscopia de Ressonância Magnética , Toxinas Marinhas/síntese química , Toxinas Marinhas/isolamento & purificação , Estrutura Molecular , Oxocinas/síntese química , Oxocinas/isolamento & purificação , Polímeros/síntese química , Polímeros/isolamento & purificação , Metabolismo Secundário , Estereoisomerismo , Relação Estrutura-Atividade
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