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1.
Recurso na Internet em Português | LIS - Localizador de Informação em Saúde | ID: lis-48258

RESUMO

O suicídio continua sendo uma das principais causas de morte em todo o mundo, de acordo com as últimas estimativas da Organização Mundial da Saúde (OMS) publicadas nesta quinta-feira (17) no relatório “Suicide worldwide in 2019”.


Assuntos
Suicídio , Organização Mundial da Saúde/organização & administração , Suicídio/prevenção & controle
2.
Recurso na Internet em Português | LIS - Localizador de Informação em Saúde | ID: lis-48259

RESUMO

A tuberculose é um grave problema de saúde pública que, por séculos, permanece entre as doenças infecciosas que mais matam no mundo.


Assuntos
Tuberculose/prevenção & controle , Brasil , Organização Mundial da Saúde/organização & administração , Tuberculose/mortalidade
5.
MMWR Morb Mortal Wkly Rep ; 70(23): 833-839, 2021 06 11.
Artigo em Inglês | MEDLINE | ID: mdl-34111057

RESUMO

In 2005, the Regional Committee of the World Health Organization (WHO) European Region (EUR) passed a resolution calling for the regional elimination of measles, rubella, and congenital rubella syndrome (CRS) (1). In 2010, all 53 countries in EUR* reaffirmed their commitment to eliminating measles, rubella, and CRS (2); this goal was included in the European Vaccine Action Plan 2015-2020 (3,4). Rubella, which typically manifests as a mild febrile rash illness, is the leading vaccine-preventable cause of birth defects. Rubella infection during pregnancy can result in miscarriage, fetal death, or a constellation of malformations known as CRS, which usually includes one or more visual, auditory, or cardiac defects (5). The WHO-recommended measles and rubella elimination strategies in EUR include 1) achieving and maintaining ≥95% coverage with 2 doses of measles- and rubella-containing vaccine (MRCV) through routine immunization services; 2) providing measles and rubella vaccination opportunities, including supplementary immunization activities (SIAs), to populations susceptible to measles or rubella; 3) strengthening surveillance by conducting case investigations and confirming suspected cases and outbreaks with laboratory results; and 4) improving the availability and use of evidence to clearly communicate the benefits and risks of preventing these diseases through vaccination to health professionals and the public (6). This report updates a previous report and describes progress toward rubella and CRS elimination in EUR during 2005-2019 (7). In 2000, estimated coverage with the first dose of a rubella-containing vaccine (RCV1) in EUR was 60%, and 621,039 rubella cases were reported (incidence = 716.9 per 1 million population). During 2005-2019, estimated regional coverage with RCV1 was 93%-95%, and in 2019, 31 (58%) countries achieved ≥95% coverage with the RCV1. During 2005-2019, approximately 38 million persons received an RCV during SIAs in 20 (37%) countries. Rubella incidence declined by >99%, from 234.9 cases per 1 million population (206,359 cases) in 2005 to 0.67 cases per 1 million population (620 cases) by 2019. CRS cases declined by 50%, from 16 cases in 2005 to eight cases in 2019. For rubella and CRS elimination in EUR to be achieved and maintained, measures are needed to strengthen immunization programs by ensuring high coverage with an RCV in every district of each country, offering supplementary rubella vaccination to susceptible adults, maintaining high-quality surveillance for rapid case detection and confirmation, and ensuring effective outbreak preparedness and response.


Assuntos
Erradicação de Doenças , Vigilância da População , Rubéola (Sarampo Alemão)/epidemiologia , Rubéola (Sarampo Alemão)/prevenção & controle , Adolescente , Criança , Pré-Escolar , Europa (Continente)/epidemiologia , Genótipo , Humanos , Incidência , Lactente , Vacina contra Rubéola/administração & dosagem , Vírus da Rubéola/genética , Vírus da Rubéola/isolamento & purificação , Cobertura Vacinal/estatística & dados numéricos , Organização Mundial da Saúde
8.
Nature ; 594(7862): 149, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-34108702
9.
Sensors (Basel) ; 21(10)2021 May 17.
Artigo em Inglês | MEDLINE | ID: mdl-34067934

RESUMO

Diffuse gliomas are the most common primary brain tumors and they vary considerably in their morphology, location, genetic alterations, and response to therapy. In 2016, the World Health Organization (WHO) provided new guidelines for making an integrated diagnosis that incorporates both morphologic and molecular features to diffuse gliomas. In this study, we demonstrate how deep learning approaches can be used for an automatic classification of glioma subtypes and grading using whole-slide images that were obtained from routine clinical practice. A deep transfer learning method using the ResNet50V2 model was trained to classify subtypes and grades of diffuse gliomas according to the WHO's new 2016 classification. The balanced accuracy of the diffuse glioma subtype classification model with majority voting was 0.8727. These results highlight an emerging role of deep learning in the future practice of pathologic diagnosis.


Assuntos
Neoplasias Encefálicas , Glioma , Neoplasias Encefálicas/diagnóstico por imagem , Glioma/diagnóstico por imagem , Humanos , Aprendizado de Máquina , Mutação , Organização Mundial da Saúde
10.
Artigo em Inglês | MEDLINE | ID: mdl-34066931

RESUMO

In response to the increasing burden of recent health emergencies and disasters, the World Health Organization (WHO) and its partners established the WHO thematic platform for health emergency and disaster risk management research network (health EDRM RN) in 2016, with the purposes of promoting global research collaboration among various stakeholders and enhancing research activities that generate evidence to manage health risks associated with all types of emergencies and disasters. With the strong support and involvement of all WHO regional offices, the health EDRM RN now works with more than 200 global experts and partners to implement its purposes. The 1st and 2nd Core Group Meetings of the health EDRM RN were held on 17-18 October 2019 and 27 November 2020, respectively, to discuss the development of a global research agenda that the health EDRM RN will focus on facilitating, promoting, synthesizing and implementing, taking into account the emergence of the coronavirus disease 2019 (COVID-19) (health EDRM RN research agenda). A focus of the meetings was the establishment of an online platform to share information and knowledge, including the databases that the health EDRM RN accumulates (WHO health EDRM knowledge hub). This paper presents a summary of the discussion results of the meetings.


Assuntos
COVID-19 , Planejamento em Desastres , Desastres , Emergências , Humanos , Gestão de Riscos , SARS-CoV-2 , Organização Mundial da Saúde
12.
Arerugi ; 70(4): 302-309, 2021.
Artigo em Japonês | MEDLINE | ID: mdl-34135253

RESUMO

The case subject was a 19-year-old exchange student from Thailand who had undergone tuberculosis (TB) treatment twice. Upon observing a shadow in the right upper lung, the patient was referred for examination; however, acid-fast bacteria test results were negative. Furthermore, high levels of total IgE and anti-aspergillus IgE and IgG antibodies were found. Bronchoscopy revealed inflammation with stenosis in the right superior lobar bronchus, and there was an outflow of yellow viscous sputum upon suctioning. After applying a localized steroid spray, the patient expectorated a large amount of sputum containing Aspergillus fumigatus. Upon administration of steroids and itraconazole, the conglomerate mass shadow's inner portion disappeared, and dilated bronchi appeared. Even though the diagnostic criteria for allergic bronchopulmonary aspergillosis (ABPA) of Rosenberg and Patterson were not strictly satisfied, ABPA was diagnosed in conjunction with the course of treatment. It was determined that prior tubercle bacilli test results were negative, and thus the patient must have had ABPA from the onset. The symptoms eased, and the patient returned to Thailand. Although pulmonary tuberculosis and ABPA are different illnesses, they share similarities in symptoms and clinical findings. Therefore, past medical history should not be believed blindly, and it is imperative to diagnosis the condition accurately by performing appropriate tests. Furthermore, we had the opportunity to view the computed tomography images of the chest 18 years after the initial examination. In the entire lung region, findings of significant bronchiectasis were presented.


Assuntos
Aspergilose Broncopulmonar Alérgica , Tuberculose , Adulto , Aspergilose Broncopulmonar Alérgica/diagnóstico , Aspergilose Broncopulmonar Alérgica/tratamento farmacológico , Aspergillus fumigatus , Humanos , Escarro , Organização Mundial da Saúde , Adulto Jovem
13.
Arerugi ; 70(4): 310-314, 2021.
Artigo em Japonês | MEDLINE | ID: mdl-34135254

RESUMO

A 12-year-old boy visited our hospital with complaints of chronic cough and dyspnea. Chest X-ray and CT revealed diffuse granular shadow in the bilateral lung fields and "Tree-in-bud appearance" in the peripheral airways, respectively. Sinusitis was present, and restrictive disorder was predominantly found in pulmonary function. The patient was diagnosed with DPB, and long-term therapy was started with low-dose clarithromycin (CAM), The patient showed a dramatic response to CAM, with improvements of both the clinical symptoms and pulmonary function within 1-2 months. According to the relevant literature, in adult patients with this disease, pulmonary dysfunction starts from an obstructive pattern; however, this is not the case in pediatric patients. It was therefore suggested that the mechanisms underlying the development of pulmonary dysfunction in cases of childhood onset differs from those with an adult onset.


Assuntos
Bronquiolite , Infecções por Haemophilus , Adulto , Bronquiolite/tratamento farmacológico , Criança , Humanos , Macrolídeos , Masculino , Organização Mundial da Saúde
14.
Arerugi ; 70(4): 315-320, 2021.
Artigo em Japonês | MEDLINE | ID: mdl-34135255

RESUMO

At the time of writing of this manuscript, four biologics were clinically available for treatment against severe asthma. The choice of four biologics has been taking into account of the results of several type 2 inflammationrelated biomarkers, and the comorbidities of asthma, such as eosinophilic chronic rhinosinusitis, allergic rhinitis, and atopic dermatitis.In this study, we have experienced a case of severe asthma complicated by eosinophilic chronic rhinosinusitis and eosinophilic otitis media, resulting in the use of four biologics, and we observed differential response of upper and lower airways. As a clear algorithm has not been established for the use of four biologics, our experience of this case would provide important lesson for considering the therapeutic strategies against severe asthma.


Assuntos
Asma , Produtos Biológicos , Rinite Alérgica , Sinusite , Asma/tratamento farmacológico , Produtos Biológicos/uso terapêutico , Humanos , Organização Mundial da Saúde
15.
No Shinkei Geka ; 49(3): 510-519, 2021 May.
Artigo em Japonês | MEDLINE | ID: mdl-34092556

RESUMO

The updated 2016 World Health Organization(WHO)classification of tumors of the central nervous system(CNS)has incorporated molecular parameters into the histopathological diagnosis of the tumor in the name of "integrated diagnosis." It has enabled more prognostically precise diagnoses of brain tumor entities; however, its practical application has also raised concerns about whether genotypes predominate over phenotypes in tumor diagnostics. In response, cIMAPCT-NOW(the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy-"Not Official WHO")was established to provide a forum for evaluating and recommending proposed changes to future CNS tumor classifications. cIMPACT has thus far published seven updates on the proposal and clarification of existing and new terms and entities. Herein, we highlight the current status of clinical application of the 2016 WHO classification and cIMPACT proposals, and the future endeavor to incorporate comprehensive genomic and epigenomic profiling of CNS tumors with the aid of artificial intelligence technology for better clinical decision-making to achieve the goal of precision medicine for each patient with brain tumors.


Assuntos
Neoplasias do Sistema Nervoso Central , Glioma , Inteligência Artificial , Glioma/diagnóstico , Glioma/genética , Humanos , Patologia Molecular , Organização Mundial da Saúde
17.
Washington, D.C.; OPS; 2021-06-15. (OPS-W/CDE/CE/21-0005).
em Espanhol | PAHO-IRIS | ID: phr-54286

RESUMO

Este perfil de la República Dominicana sobre la salud y el cambio climático ofrece un resumen de la información sobre los riesgos climáticos, las vulnerabilidades en materia de salud, las repercusiones sobre la salud y los avances logrados hasta la fecha gracias a los esfuerzos del sector de la salud para establecer un sistema de salud resiliente al clima. El proyecto de perfiles de países sobre la salud y el cambio climático de la Organización Mundial de la Salud (OMS), la Organización Panamericana de la Salud (OPS) y la Convención Marco de las Naciones Unidas sobre el Cambio Climático (CMNUCC) hace un seguimiento de los efectos del cambio climático en la salud y de los avances en la creación de sistemas de salud resistentes al clima. Mediante la publicación de perfiles nacionales actualizados cada cuatro años, el proyecto no solo proporciona un panorama sobre una serie de indicadores nacionales de salud y cambio climático, sino que también crea un mecanismo para seguir los efectos en la salud y las respuestas del sector de la salud relacionados con el clima a lo largo del tiempo. En el 2015, durante el primer ciclo del proyecto, se publicaron casi 50 perfiles de países. El número de perfiles de países se ha ampliado de manera considerable en el segundo ciclo. Los perfiles de países se elaboran en estrecha colaboración con las oficinas regionales y nacionales de la OMS, las autoridades de salud nacionales y otras partes interesadas del sector de la salud. Los objetivos generales del proyecto son los siguientes: 1) aumentar la concienciación sobre los efectos en la salud del cambio climático, 2) apoyar la toma de decisiones basada en evidencia con vistas a reforzar la resiliencia de los sistemas de salud, 3) apoyar la participación del sector de la salud en los procesos nacionales e internacionales relacionados con el clima y 4) promover acciones que mejoren la salud al tiempo que reducen las emisiones de gases de efecto invernadero.


Assuntos
Mudança Climática , Clima , Efeitos do Clima , Sistemas de Saúde , Nações Unidas , Organização Mundial da Saúde , Organização Pan-Americana da Saúde , Setor de Assistência à Saúde , Efeito Estufa , República Dominicana
18.
Recurso na Internet em Português | LIS - Localizador de Informação em Saúde | ID: lis-48200

RESUMO

A Organização Mundial da Saúde (OMS) listou nesta sexta-feira (7) a vacina contra a COVID-19 da Sinopharm para uso emergencial, dando luz verde para que este imunizante seja lançado globalmente. A vacina é produzida pelo Beijing Bio-Institute of Biological Products Co Ltd., China National Biotec Group (CNBG).


Assuntos
Políticas, Planejamento e Administração em Saúde , Vacinas/imunologia , Organização Mundial da Saúde/organização & administração , Infecções por Coronavirus , Serviços Médicos de Emergência
19.
Recurso na Internet em Português | LIS - Localizador de Informação em Saúde | ID: lis-48192

RESUMO

A Organização Mundial da Saúde (OMS) lançou nesta terça-feira (4) um novo conjunto de referências globais para os níveis de sódio em mais de 60 categorias de alimentos que ajudarão os países a reduzir o teor de sódio nos alimentos para melhorar a alimentação e salvar vidas.


Assuntos
Cloreto de Sódio/análise , Parâmetros de Referência/análise , Organização Mundial da Saúde/organização & administração , Sódio/análise
20.
Recurso na Internet em Inglês, Português | LIS - Localizador de Informação em Saúde | ID: lis-48193

RESUMO

A última pesquisa global da Organização Mundial da Saúde (OMS) sobre a implementação de programas nacionais de prevenção e controle de infecções destaca a necessidade urgente de reduzir as desigualdades na disponibilidade de boa higienização das mãos e outras medidas de prevenção e controle de infecções entre países de alta e baixa renda.


Assuntos
Organização Mundial da Saúde , Higiene das Mãos/métodos , Controle de Infecções/métodos , Conhecimentos, Atitudes e Prática em Saúde
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