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1.
Recurso na Internet em Inglês, Espanhol, Português | LIS - Localizador de Informação em Saúde | ID: lis-LISBR1.1-47368

RESUMO

Este mapa apresenta uma visão geral das evidências sobre os efeitos da Ozonoterapia Bucal para várias condições clínicas e de saúde das pessoas a partir da caracterização de 15 estudos de revisão, distribuídos graficamente em uma matriz com 6 intervenções em uma série de resultados clínicos agrupados em 9 categorias. A maioria dos estudos concentra-se na intervenção com água ozonizada tópica e mistura gasosa oxigênio-ozônio tópica aplicada no tratamento de cárie, dor, cicatrização e inflamação. Este mapa proporciona una visión general de la evidencia sobre los efectos de la ozonoterapia oral para diversas afecciones clínicas y de salud de las personas a partir de la caracterización de 15 estudios de revisión, distribuidos gráficamente en una matriz con 6 intervenciones en una serie de resultados clínicos agrupados en 9 categorías. La mayoría de los estudios se centran en la intervención con agua ozonizada tópica y una mezcla tópica de gas oxígeno-ozono aplicada en el tratamiento de caries, dolor, cicatrices e inflamación. Investigadores del Centro de Excelencia Prótese Implante de la Facultad de Odontología de la Universidade de São Paulo (FOUSP) fueron colaboradores del mapa. This map displays an overview of the evidence on the effects of oral ozone therapy for various clinical and health conditions from the characterization of 15 review studies, graphically distributed in a matrix with 6 interventions in a series of clinical results grouped in 9 categories. Most studies focus on intervention with topical ozonized water and topical oxygen-ozone gas mixture applied in the treatment of caries, pain, scarring and inflammation. The Map had collaboration of researchers from "Centro de Excelencia Prótese Implante" of the Dentistry Faculty of the University of São Paulo (FOUSP) colaborated in this Map.


Assuntos
Ozônio/uso terapêutico , Medicina Baseada em Evidências/instrumentação , Revisões Sistemáticas como Assunto , Cárie Dentária/terapia , Saúde Bucal/tendências , Resultado do Tratamento
2.
Recurso na Internet em Inglês, Espanhol, Português | LIS - Localizador de Informação em Saúde | ID: lis-LISBR1.1-47377

RESUMO

Este mapa apresenta uma visão geral das evidências e lacunas existentes sobre os efeitos da Ozonioterapia Médica para diversas condições clinicas e de saúde das pessoas. A partir de uma ampla busca bibliográfica de estudos publicados e não publicados entre 2000 e meados de 2019, foram incluídas no mapa 14 revisões sistemáticas. Todos os estudos foram avaliados, caracterizados e categorizados pela Sociedade Brasileira de Ozonioterapia Médica (SOBOM) e contou com o apoio da World Federation of Ozone Therapy (WFOT). Este mapa presenta una visión general de la evidencia y las lagunas existentes sobre los efectos de la Ozonoterapia Médica para diversas condiciones clínicas y de salud de las personas. A partir de una amplia búsqueda bibliográfica de estudios publicados y no publicados entre 2000 y mediados de 2019, se incluyeron 14 revisiones sistemáticas en el mapa.Todos los estudios fueron evaluados, caracterizados y categorizados por la Sociedad Brasileña de Ozonioterapia Médica (SOBOM) y tuve el apoyo de la World Federation of Ozone Therapy (WFOT). This map provides an overview of the evidence and gaps that exist on the effects of Medical Ozone Therapy for various clinical and health conditions of people. From a broad bibliographic search of published and unpublished studies between 2000 and mid-2019, 14 systematic reviews were included in the map. All studies were evaluated, characterized and categorized by the Brazilian Society of Medical Ozone Therapy (SOBOM) with support from the World Federation of Ozone Therapy (WFOT).


Assuntos
Ozônio/uso terapêutico , Resultado do Tratamento , Medicina Baseada em Evidências/métodos
4.
Medicine (Baltimore) ; 99(16): e19819, 2020 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-32312002

RESUMO

RATIONALE: Phantom limb pain (PLP) refers to a common complication following amputation, which is characterized by intractable pain in the absent limb, phantom limb sensation, and stump pain. The definitive pathogenesis of PLP has not been fully understood, and the treatment of PLP is still a great challenge. Till now, ozone injection has never been reported for the treatment of PLP. PATIENT CONCERNS: We report 3 cases: a 68-year-old man, a 48-year-old woman, and a 46-year-old man. All of them had an amputation history and presented with stump pain, phantom limb sensation, and sharp pain in the phantom limb. Oral analgesics and local blocking in stump provided no benefits. DIAGNOSIS: They were diagnosed with PLP. INTERVENTIONS: We performed selective nerve root ozone injection combined with ozone injection in the stump tenderness points. OUTCOMES: There were no adverse effects. Postoperative, PLP, and stump pain were significantly improved. During the follow-up period, the pain was well controlled. LESSONS: Selective nerve root injection of ozone is safe and the outcomes were favorable. Ozone injection may be a new promising approach for treating PLP.


Assuntos
Cotos de Amputação/inervação , Amputação/efeitos adversos , Ozônio/administração & dosagem , Dor Intratável/terapia , Membro Fantasma/complicações , Idoso , Cotos de Amputação/fisiopatologia , Feminino , Humanos , Injeções/métodos , Masculino , Pessoa de Meia-Idade , Ozônio/uso terapêutico , Dor Intratável/etiologia , Membro Fantasma/fisiopatologia , Raízes Nervosas Espinhais/efeitos dos fármacos , Resultado do Tratamento
6.
Madrid; s.n; mar. 2020.
Não convencional em Inglês | MOSAICO - Saúde integrativa | ID: biblio-1095104

RESUMO

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; provisionally named 2019 novel coronavirus or 2019-nCoV) disease (COVID-19) in China at the end of 2019 has caused a large global outbreak and is a major public health issue. As of March 9 th, 2020, data from the World Health Organization (WHO) have shown that confirmed cases surpassed 112,000 and have been identified in 112 countries/regions, with 3,893 deaths. On January 30th 2020, the WHO declared COVID-19 as the sixth public health emergency of international concern. The scope of this paper is to review the potential use of ozone therapy that could serves as a complementary therapy in the management of COVID-19. Evidence acquisition terms (ozone, SARS-CoV-2 and COVID-19) was searched in the scientific data bases. Ozone can be used in the disinfection of viral contaminated environments. Its maximum anti-viral efficacy requires a short period of high humidity (>90% relative humidity) after the attainment of peak ozone gas concentration (20 ­ 25 ppm, 39-49 mg/m3 ). As a gas it can penetrate all areas within a room, including crevices, fixtures, fabrics, hospital room, public transport, hotel room, cruise liner cabin, office, etc. and under surfaces of furniture, much more efficiently than manually applied liquid sprays and aerosols. The environment to be treated must be free of people and animals due to the relative toxicity of ozone via inhalation. Systemic ozone therapy can be potentially useful in SARS-CoV-2. The rationale and mechanism of action has already been proven clinically in other viral infections and has been shown to be highly effective in research studies. The mechanism of action will be by 1) The induction of adaptation to oxidative stress, hence a re-equilibration of the cellular redox state. 2) The induction of IFN-gamma and proinflammatory cytokines. 3) The increase of blood flow and tissue oxygenation to vital organs. 4) It has the potential actions to act as an auto-vaccine when administered in form of minor autohemotherapy. The recommended routes of administration are: Major Autohemotherapy (MAH), Ozonized Saline Solution (O3SS), Extracorporeal Blood Oxygenation-Ozonation (EBOO), and a variant of the Minor Autohemotherapy (MiAH). Clinical protocol should be adhered to with the standard doses and procedures as defined in the Madrid Declaration of Ozone Therapy. At least three clinical trials using major autohemotherapy are currently being undertaken in China and more clinical trials and data are needed to confirm the efficacy of ozone therapy as a complementary therapy in COVID-19 diseases. It is a complementary therapy because while the infected patient will continue to be treated with allopathic medicine, at the same time the patient will receive the treatment that this paper is proposing.(AU)


Assuntos
Humanos , Ozônio/uso terapêutico , Pneumonia Viral/terapia , Infecções por Coronavirus/terapia , Espanha
7.
Arq. bras. med. vet. zootec. (Online) ; 72(1): 56-64, Jan.-Feb. 2020. graf
Artigo em Inglês | LILACS, VETINDEX | ID: biblio-1088913

RESUMO

Ozone (O3) therapy has been used for medical procedures for centuries; however, there are no extensive studies on its utilization in horses. This study aimed to evaluate the application of transrectal O3 on horses by physical and laboratorial evaluation, and production of reactive oxygen species (ROS). Sixteen healthy horses were separated in two groups: a control group (CG) and a group treated with O3 (TG). The TG animals received 1L of an oxygen and O3 mixture transrectally. The initial dose was 10µg/ml for the first two applications, 15µg/ml for the following two applications, and 20µg/ml for the next six applications. The CG animals received 1L of oxygen transrectally. In TG animals no variations in the physical examination were detected; furthermore, TG animals did not exhibit changes in biochemical evaluation results, fibrinogen concentrations, or ROS production. TG animals had increased red blood cell counts, hemoglobin concentrations, and packet cell volume values in comparison to the baseline and CG values. We could infer that O3 affected the red blood cell counts and improved rhetological properties of the blood. The transrectal application of O3 in horses is safe and can indirectly improve the oxygenation and metabolism of tissues.(AU)


A utilização medicinal do ozônio (O3) é secular, contudo não existem estudos expressivos de sua utilização em equinos. O objetivo deste estudo foi avaliar o efeito da aplicação transretal de O3 em equinos por meio da avaliação física, laboratorial, e produção de espécies reativas de oxigênio (EROs). Dezesseis equinos hígidos foram separados em dois grupos: grupo controle (GC) e grupo tratado com O3 (GT). O GT recebeu por via retal 1L da mistura de oxigênio e ozônio, sendo a dose inicial de 10µg/ml por duas aplicações, 15µg/ml por mais duas aplicações e 20µg/ml por seis aplicações. O GC recebeu 1L de oxigênio via transretal. No GT não foram observadas alterações no exame físico, bem como não foram observadas alterações na avaliação bioquímica, concentração de fibrinogênio e produção de EROs. O GT apresentou aumento no número de hemácias, na concentração de hemoglobina, e nos valores de hematócrito em relação aos valores basais e GC. Podemos inferir que o O3 alterou os valores de eritrócitos e melhorou as propriedades reológicas do sangue. Conclui-se que a aplicação transretal de 03 em equinos é segura e pode melhorar indiretamente a oxigenação e metabolismo dos tecidos.(AU)


Assuntos
Animais , Ozônio/uso terapêutico , Administração Retal , Espécies Reativas de Oxigênio , Cavalos/sangue , Antioxidantes
8.
J Biol Regul Homeost Agents ; 33(5 Suppl. 1): 91-94, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31630721

RESUMO

The natural history of children with end stage renal disease is dialysis until a transplant can be done. There are two types of dialysis: hemodialysis and peritoneal dialysis (1). Peritoneal dialysis is preferred in young children because getting the vascular access for hemodialysis is challenging (2). Catheters should be surgically placed in a paramedian or lateral abdominal region with an extremity located in Douglas' pouch.


Assuntos
Falência Renal Crônica/terapia , Ozônio/uso terapêutico , Diálise Peritoneal , Criança , Humanos
9.
Int J Mol Sci ; 20(16)2019 Aug 17.
Artigo em Inglês | MEDLINE | ID: mdl-31426459

RESUMO

Ozone (O3) is a natural, highly unstable atmospheric gas that rapidly decomposes to oxygen. Although not being a radical molecule, O3 is a very strong oxidant and therefore it is potentially toxic for living organisms. However, scientific evidence proved that the effects of O3 exposure are dose-dependent: high dosages stimulate severe oxidative stress resulting in inflammatory response and tissue injury, whereas low O3 concentrations induce a moderate oxidative eustress activating antioxidant pathways. These properties make O3 a powerful medical tool, which can be used as either a disinfectant or an adjuvant agent in the therapy of numerous diseases. In this paper, the cellular mechanisms involved in the antioxidant response to O3 exposure will be reviewed with special reference to the activation of nuclear factor erythroid 2-related factor 2 (Nrf2) and its role in the efficacy of ozone therapy.


Assuntos
Antioxidantes/metabolismo , Inflamação , Fator 2 Relacionado a NF-E2/metabolismo , Estresse Oxidativo , Ozônio/farmacologia , Animais , Humanos , Neoplasias/tratamento farmacológico , Neoplasias/metabolismo , Ozônio/uso terapêutico , Resultado do Tratamento
10.
J Neurol Surg A Cent Eur Neurosurg ; 80(6): 503-506, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31430795

RESUMO

Oxygen-ozone therapy is used to treat degenerative pathology of the spine when surgery is not needed (e.g., removal of a herniated disk). Some authors have described it as a safe and effective procedure in ∼ 70 to 90% of patients. The aim of the therapy is to dehydrate the intervertebral disk and alter its contents. However, this treatment has been associated with some rare but very serious side effects. Both cardiac damage and a case of fulminant septicemia were reported. We describe a case of suspected pulmonary embolism, followed by sudden death, in an elderly woman treated with oxygen-ozone therapy for lumbar pain caused by disk protrusion. We believe a massive pulmonary embolism occurred, probably caused by an intradiskal injection that accidentally punctured a venous vessel and created emboli.


Assuntos
Deslocamento do Disco Intervertebral/terapia , Dor Lombar/terapia , Oxigênio/efeitos adversos , Ozônio/efeitos adversos , Embolia Pulmonar/etiologia , Idoso de 80 Anos ou mais , Feminino , Humanos , Deslocamento do Disco Intervertebral/complicações , Dor Lombar/etiologia , Oxigênio/uso terapêutico , Ozônio/uso terapêutico
11.
Rev. cuba. angiol. cir. vasc ; 20(1)ene.-jun. 2019. tab
Artigo em Espanhol | LILACS | ID: biblio-991042

RESUMO

Introducción: El Heberprot-P® es un medicamento novedoso y único, prescrito para los pacientes con úlcera del pie diabético. El factor de crecimiento humano recombinante que contiene este fármaco induce el crecimiento de tejido de granulación útil. La ozonoterapia tiene propiedades como oxigenante, antioxidante, inmunomodulador, regenerador, antiinflamatorio y germicida y se utiliza para la desinfección de heridas desde la Primera Guerra Mundial. Objetivo: Determinar la evolución de las úlceras del pie diabético con el tratamiento mixto de Heberprot-P® y ozonoterapia. Métodos: Se realizó un estudio retrospectivo y descriptivo en todos los pacientes ingresados en el Instituto Nacional de Angiología y Cirugía Vascular con el diagnóstico de diabetes mellitus y úlcera de pie diabético que recibieron tratamiento mixto de Heberprot-P® y ozonoterapia. El período de estudio osciló de enero de 2016 hasta enero de 2017. Las variables estudiadas fueron: sexo, edad, tipo de diabetes, estadía hospitalaria, necesidad de ser reintervenido, tiempo de granulación y respuesta al tratamiento. Resultados: Se encontró que los pacientes tratados con el Heberprot-p® y ozonoterapia tuvieron una buena respuesta al tratamiento (60,5 por ciento), un tiempo de granulación entre 2 y 4 semanas (55,6 por ciento) con predominio de la estadía hospitalaria de 11 a 21 días. Conclusiones: Los pacientes con el tratamiento mixto de Heberprot-P® y ozonoterapia tienen una respuesta muy favorable(AU)


Introduction: Heberprot-P® is a novel and unique medication, prescribed for patients with diabetic foot ulcer. It is based on recombinant human growth factor that induces the growth of useful granulation tissue. The properties as oxygenating, antioxidant, immunomodulator, regenerator, anti-inflammatory and germicide of ozone therapy are used for the disinfection of wounds since the First World War. Objective: To determine the evolution of diabetic foot ulcers with the mixed treatment of Heberprot-P® and ozone therapy. Methods: A retrospective and descriptive study was conducted in all patients admitted to the National Institute of Angiology and Vascular Surgery (INACV) with the diagnosis of Diabetes Mellitus and diabetic foot ulcer who received mixed treatment of Heberprot-P® and ozone therapy. The study period ranged from January 2016 to January 2017. The studied variables were: sex, age, type of diabetes, hospital stay, need to be reoperated, granulation time and response to the treatment. Results: It was found that the highest percentage of patients who used the mixed treatment of Heberprot-P® and ozone therapy had a good response to treatment (60.5 percent) and a granulation time between 2 and 4 weeks (55.6 percent); and a hospital stay from 11 to 21 days. Conclusions: Patients with the mixed treatment of Heberprot-P® and ozone therapy have a very favorable response(AU)


Assuntos
Humanos , Masculino , Feminino , Ozônio/uso terapêutico , Pé Diabético/tratamento farmacológico , Medicamentos de Referência , Epidemiologia Descritiva , Estudos Retrospectivos
12.
Arq. bras. med. vet. zootec. (Online) ; 71(3): 953-958, May-June 2019. tab, ilus
Artigo em Português | LILACS, VETINDEX | ID: biblio-1011294

RESUMO

O emprego conjunto da laserterapia e da ozonioterapia em feridas apresenta alto potencial benéfico para os pacientes, uma vez que contribui para o manejo da dor, tem ação anti-inflamatória e acelera o processo de cicatrização. Este relato de caso tem como objetivo apresentar o uso de terapias alternativas na cicatrização de ferida em exemplar de Coendou prehensilis. Um ouriço-cacheiro, fêmea, adulto, com peso de 4kg foi encaminhado para atendimento médico veterinário com histórico de ter sido atacado por um cão. Inicialmente o ouriço passou pelo procedimento de higienização e desbridamento da ferida, para a retirada das bordas necróticas. Adicionalmente, foram administrados clindamicina (10mg/kg), por via intramuscular (IM), uma vez por dia (SID), tramadol (4mg/kg, IM, SID), flunixin (0,3mg/kg, SID), por via subcutânea (SC), e ferrodextrano (25mg/kg, IM, SID). Apesar da terapia instituída, observou-se reincidência de crescimento necrótico tecidual, o que levou à eleição do tratamento da ferida com as técnicas de laserterapia e ozonioterapia. O emprego das terapias alternativas como adjuvante promoveu uma cicatrização satisfatória da ferida, com ausência de sinais de sensibilidade local e de infecção, bem como ausência de crescimento de bordas necróticas. O tratamento adjuvante foi eficaz e pode ser empregado em outras situações para cicatrização de ferida em mamíferos silvestres.(AU)


The use of therapy with laser beam and ozone in wounds has a high beneficial potential for patients, since it contributes to the management of pain, has an anti-inflammatory action and accelerates the cicatricial process. Due to this casuistry importance, the case report aims to present alternative therapy use for wound healing on a Coendou prehensilis. Thus, a female of C. prehensilis weighing 4kg, was sent to veterinary care. At first there was a hygiene process and debridement for necrotic edge removal. Furthermore, injected clindamycin (10mg/kg) was administered intramuscularly (IM), once a day (SID), tramadol (4mg/kg, IM, SID), flunixin (0.3mg/kg, SID), administered subcutaneously (SC) and iron dextran (25mg/kg, IM, SID). In spite of the established therapy, tissue necrotic growth was observed, which lead the wound treatment as healing by second intention, initiating an alternative therapy with laser beam and ozone. As a result, the healing was satisfactory due to the elected techniques, without signs of pain and infection. The adjuvant treatment with physiotherapy had advantageous effect and could be applied to wound healing in wild mammal animals.(AU)


Assuntos
Animais , Cicatrização , Porcos-Espinhos/lesões , Ozônio/uso terapêutico , Mordeduras e Picadas/veterinária , Fisioterapia/métodos , Terapia a Laser/veterinária
14.
Cochrane Database Syst Rev ; 2: CD004153, 2019 02 07.
Artigo em Inglês | MEDLINE | ID: mdl-30731019

RESUMO

BACKGROUND: Dental caries is a bacterially mediated disease characterised by demineralisation of the tooth surface, which may lead to cavitation, discomfort, pain and eventual tooth loss. Ozone is toxic to certain bacteria in vitro and it has been suggested that delivering ozone into a carious lesion might reduce the number of cariogenic bacteria. This possibly could arrest the progress of the lesion and may, in the presence of fluoride, perhaps allow remineralisation to occur. This may in turn delay or prevent the need for traditional dental conservation by 'drilling and filling'. OBJECTIVES: To assess whether ozone is effective in arresting or reversing the progression of dental caries. SEARCH METHODS: We searched the Cochrane Oral Health Group's Trials Register (to 7 November 2003); Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2003, Issue 3); MEDLINE and PREMEDLINE (OVID) (1966 to November 2003); EMBASE (OVID) (1980 to November 2003); CINAHL (OVID) (1982 to November 2003); AMED (OVID) (1985 to November 2003). Quintessence was handsearched through 2002 and KaVo were contacted as manufacturers of the HealOzone apparatus for any additional published or unpublished trials. SELECTION CRITERIA: Inclusion was assessed independently by at least two reviewers. Trials were only included if they met the following criteria: randomisation in a controlled trial; single surface in vivo carious lesion accessible to ozone application; clear allocation concealment; ozone application to the lesions in the intervention group; no such application of ozone in the control group; outcomes measured after at least 6 months. DATA COLLECTION AND ANALYSIS: Reviewers independently extracted information in duplicate. A paucity of comparable data did not allow meta-analytic pooling of the included studies. MAIN RESULTS: Three trials were included, with a combined total of 432 randomised lesions (137 participants). Forty-two conference papers, abstracts and posters were excluded (from an unknown number of studies). The risk of bias in all studies appeared high. The analyses of all three studies were conducted at the level of the lesion, which is not independent of the person, for this reason pooling of data was not appropriate or attempted. Individual studies showed inconsistent effects of ozone on caries, across different measures of caries progression or regression. Few secondary outcomes were reported, but one trial reported an absence of adverse events. AUTHORS' CONCLUSIONS: Given the high risk of bias in the available studies and lack of consistency between different outcome measures, there is no reliable evidence that application of ozone gas to the surface of decayed teeth stops or reverses the decay process. There is a fundamental need for more evidence of appropriate rigour and quality before the use of ozone can be accepted into mainstream primary dental care or can be considered a viable alternative to current methods for the management and treatment of dental caries.


Assuntos
Cariostáticos/uso terapêutico , Cárie Dentária/tratamento farmacológico , Ozônio/uso terapêutico , Fissuras Dentárias/tratamento farmacológico , Humanos , Ensaios Clínicos Controlados Aleatórios como Assunto
15.
Clin Oral Investig ; 23(10): 3789-3799, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-30759283

RESUMO

OBJECTIVES: The aim of this randomized, three-arm parallel, single-blinded clinical trial was to evaluate the clinical and microbiological effectiveness of the ozone application in two-visit indirect pulp therapy. MATERIALS AND METHODS: One hundred five lower first molar teeth with deep caries lesion were included and randomly assigned three groups to apply the two-visit indirect pulp therapy. Treatment procedure was applied without any disinfectant (control), with 60-s 2% chlorhexidine digluconate (CHX) or 60-s ozone application. In four different stages (after initial excavation, ozone/CHX application before the temporary restoration, 4 months later immediately after removing temporary restoration, and final excavation), dentin humidity, consistency, and color properties were recorded to evaluate the clinical characteristics of the tissue, and standard dentin samples were collected for the microbiological analysis of mutans streptococci, lactobacilli, and the total number of colony-forming units. The data were analyzed by using Mann-Whitney U test for multiple comparisons. RESULTS: The remaining dentin became harder, drier, and darker after 4 months in all groups. However, CHX and ozone application were statistically better than the control group (p < 0.05). There was a gradual decrease in the total number of microorganisms in all groups. While cavity disinfectant applications were improved the antibacterial efficacy (control, 79.11%; CHX, 98.39%; ozone, 93.33%), CHX application exhibited a greater significant reduction than both groups (p = 0.000). CONCLUSION: The two-visit indirect pulp therapy yielded successful results for all study groups. However, CHX would be conveniently preferable due to improving the treatment success. CLINICAL RELEVANCE: The two-visit indirect pulp therapy applied with cavity disinfectant is a proper alternative treatment procedure in deep carious lesions, instead of conventional technique.


Assuntos
Cárie Dentária/terapia , Desinfetantes de Equipamento Odontológico/uso terapêutico , Dente Molar/patologia , Ozônio/uso terapêutico , Exposição da Polpa Dentária , Dentina , Humanos , Streptococcus mutans
16.
Oral Dis ; 25(4): 1195-1202, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30739369

RESUMO

OBJECTIVES: The aim of this randomized split-mouth clinical trial was to evaluate the effects of ozone therapy on clinical and biochemical parameters of moderate to severe generalized periodontitis patients after non-surgical periodontal therapy. METHODS: A total of 36 moderate to severe generalized periodontitis patients were included in the study. The patients were systemically healthy and 18 to 64 years of age. Periodontal parameters, including plaque index (PI), gingival index (GI), probing depth (PD), percentage of bleeding on probing, percentage of pockets deeper than 5 mm and clinical attachment level (CAL), and percentage of ≥3 mm CAL, were evaluated at baseline and 3 months following periodontal therapy. All participants were treated non-surgically. Topical gaseous ozone was applied into periodontal pockets twice a week for 2 weeks during active periodontal therapy. Gingival crevicular fluid pentraxin-3 (PTX-3), interleukin-1ß (IL-1ß), and high sensitivity C-reactive protein (Hs-CRP) were evaluated. All statistical data were analyzed using SPSS software. RESULTS: Total of 36 participants completed the study (18 males, 18 females). PI, GI, PD, percentage of bleeding on probing, percentage of pockets deeper than 5 mm and CAL, and percentage of ≥3 mm CAL were improved, and there were no significant differences between the two sides. All inflammatory parameters, PTX-3, Hs-CRP, and IL-1, were reduced at 3-month follow-up. Only the decrease in PTX-3 levels between baseline and 3-month follow-up was statistically significant. CONCLUSIONS: Ozone therapy did not have any additional effect on periodontal parameters. All cytokines were reduced after periodontal therapy. Only PTX-3 levels were significantly lower at ozone sites compared to those at the control sites.


Assuntos
Periodontite Crônica/terapia , Ozônio/uso terapêutico , Adolescente , Adulto , Idoso , Índice de Placa Dentária , Raspagem Dentária , Feminino , Seguimentos , Líquido do Sulco Gengival , Humanos , Masculino , Pessoa de Meia-Idade , Índice Periodontal , Aplainamento Radicular , Resultado do Tratamento , Adulto Jovem
17.
Artigo em Russo | MEDLINE | ID: mdl-30724877

RESUMO

BACKGROUND: Alveolitis and localized osteomyelitis of the jawbones still remain the most common conditions among the post-operative complications associated with tooth extraction. AIM: The objective of the present study was to evaluate the antibacterial and clinical effectiveness of ozone therapy and radiation of various wavelengths emitted by the light-emitting diodes (LED) applied for the treatment of alveolitis and localized osteomyelitis of the jawbone with a view to improving the effectiveness of the treatment and shortening the duration of the rehabilitation period. MATERIAL AND METHODS: A total of 100 patients presenting with alveolitis and localized osteomyelitis of the jawbones at the age varying from 18 to 65 years have been examined and treated. All the patients were divided into four equal groups. The first group (1) was comprised of the patients who were treated with the combination of the measures which included the course of ozone therapy and LED-emitted red light radiation (630 nm); the patients of the second group (2) were treated using ozone therapy in the combination with LED-emitted green light radiation (530 nm); in the third group (3), ozone therapy in the combination with LED-emitted (470 nm) blue light radiation was used. The patients of the fourth group (4) were managed without the application of the physiotherapeutic factors. To study the effects of ozone therapy and LED-emitted radiation of different wavelengths on the microflora of the extracted tooth socket, the bacteriological analysis was carried out three times - before the treatment, within three and five days after its initiation. RESULTS: The present study has demonstrated that the combination of ozone therapy with LED-emitted (630 nm) red light radiation provides the most efficient tool for the treatment of alveolitis whereas ozone therapy in the combination with LED-emitted (470 nm) blue light radiation should be preferred for the treatment of localized osteomyelitis of the jawbone. CONCLUSIONS: The results of this study are of primary importance as giving evidence of the significant reduction in the duration of the rehabilitation period in the patients presenting with alveolitis and localized osteomyelitis of the jawbones.


Assuntos
Doenças Maxilomandibulares/terapia , Osteomielite/terapia , Modalidades de Fisioterapia , Transtornos Respiratórios/terapia , Adolescente , Adulto , Idoso , Humanos , Pessoa de Meia-Idade , Ozônio/uso terapêutico , Resultado do Tratamento , Adulto Jovem
18.
Khirurgiia (Mosk) ; (1): 37-42, 2019.
Artigo em Russo | MEDLINE | ID: mdl-30789606

RESUMO

AIM: To analyze efficiency of ozone therapy, ultrasound and cryotherapy for infected and purulent wounds due to chronic venous insufficiency. MATERIAL AND METHODS: There were 127 patients with chronic venous insufficiency followed by chronic wounds. Efficacy of systemic and local ozone therapy was assessed. De Sole method was used to analyze chemiluminescent and spontaneous activity of neutrophils of peripheral blood. RESULTS: Advanced generation of active forms of oxygen was revealed in patients with chronic wounds and chronic venous insufficiency. Complex ozone therapy including intravenous administration of ozonized autologous blood, oxygen-ozone and ultrasonic exposure of the wound and cryogenic stimulation reduce painful period up to 3.1±0.6 days, accelerate epithelialization of the wound and normalize release of active forms of oxygen.


Assuntos
Neutrófilos/imunologia , Insuficiência Venosa/imunologia , Cicatrização/imunologia , Ferimentos e Lesões/imunologia , Ferimentos e Lesões/terapia , Doença Crônica , Crioterapia , Humanos , Medições Luminescentes , Oxidantes Fotoquímicos/uso terapêutico , Ozônio/uso terapêutico , Terapia por Ultrassom , Insuficiência Venosa/complicações , Insuficiência Venosa/fisiopatologia , Ferimentos e Lesões/etiologia , Ferimentos e Lesões/fisiopatologia
19.
Pesqui. bras. odontopediatria clín. integr ; 19(1): 4442, 01 Fevereiro 2019. tab, ilus
Artigo em Inglês | LILACS, BBO - Odontologia | ID: biblio-998041

RESUMO

Objective: To investigate the efficacy of transdermal high-frequency ozone therapy in the management of pain and pain-related restricted jaw movements in patients with internal derangement of the temporomandibular joint (TMJ). Material and Methods: This retrospective study included 40 patients who had received transdermal high-frequency ozone therapy for the management of disc displacement with reduction of the TMJ. Subjects were treated 3 times for one week with a bio-oxidative high-frequency ozone generator with an intensity of 80% for ten minutes bilaterally. Pain scores and maximal interincisal opening (MIO) values of the patients were evaluated before and after the treatment. Results: An increase in the mean MIO value was achieved following the ozone therapy, however, the difference was not statistically significant (p=0.350). A statistically significant decrease in the mean pain score (48.13 ± 27.75) was observed following the ozone therapy. Conclusion: Transdermal application of high frequency ozone may be a good alternative for management of pain and pain-related restricted jaw movements in patients with internal derangement of the TMJ.


Assuntos
Humanos , Ozônio/uso terapêutico , Articulação Temporomandibular , Dor Facial/diagnóstico , Transtornos da Articulação Temporomandibular , Peru , Análise de Variância , Estatísticas não Paramétricas
20.
Rev. medica electron ; 41(1): 54-62, ene.-feb. 2019. tab
Artigo em Espanhol | LILACS, CUMED | ID: biblio-991325

RESUMO

RESUMEN Introducción: La constante y diversa disponibilidad de nuevos fármacos, nos ofrece opciones alternativas de tratamiento. El oleozón tópico es un medicamento aun en experimento y validación de sus indicaciones. Existen suficientes evidencias de su efecto antimicrobiano y cicatrizante. Objetivo: evaluar la eficacia del oleozón tópico en el tratamiento de la gingivitis crónica fibroedematosa. Materiales y métodos: se realizó un estudio experimental y aleatorizado. El período de estudio fue de septiembre de 2015 a junio de 2017. Se tomó una muestra de 60 pacientes pertenecientes al municipio de Palmira, entre 18 y 35 años, con diagnóstico de gingivitis crónica fibroedematosa que acudieron a los servicios en el período comprendido, luego de cumplir los criterios de inclusión y consentimiento informado, se dividieron de forma aleatorizada simple en dos grupos: estudio y control. Se utilizaron métodos del nivel teórico, histórico- lógico, documental en la revisión bibliográfica y teórica del tema de investigación, inducción - deducción para el análisis de los propósitos y pasos lógicos de la investigación. Resultados: a pesar de no encontrar diferencias significativas entre los grupos de pacientes tratados con oleozón tópico y clohexidina, recomendamos su inclusión en las Guías Prácticas de Estomatología, como tratamiento alternativo de la gingivitis crónica fibroedematosa. Conclusiones: no se encontraron diferencias significativas respecto a la eficacia del oleozón tópico y clohexidina en el tratamiento de la gingivitis crónica fibroedematosa, ambos tratamientos fueron resolutivos por igual en la mayoría de los casos.


ABSTRACT Introduction: the constant and diverse availability of new drugs offers alternative options of treatment. The topic Oleozón® is a drug that is still being tested and validated. There are evidences enough of its antimicrobial and healing effect. Objective: to evaluate the efficacy of topic Oleozón® in the treatment of chronic fibro-edematous gingivitis. Material and method: an experimental randomized study was carried out. The studied period was September 2015-June 2017. The sample were 60 patients living in the municipality of Palmira, aged 18-35 years old, with diagnosis of chronic fibro-edematous gingivitis who assisted the dental services in the before mentioned period and fulfilled the inclusion criteria and gave their informed consent. They were randomly divided into two groups: the study and the control groups. There were used methods of the theoretic, logic-historical and documental level in the bibliographic and theoretical review of the research theme, the induction-deduction method for the analyses of the purposes and logical steps of the research. Results: although there were not found significant differences between the groups of patients treated with topic Oleozón® and clorhexidine, the authors recommend their inclusion in Guias Prácticas de Estomatología as an alternative treatment of the chronic fibro-edematous gingivitis. Conclusions: there were not found significant differences between the groups of patients treated with topic Oleozón® and clorhexidine in the treatment of chronic fibro-edematous gingivitis; both treatments were decisive at the same level in most of the cases.


Assuntos
Humanos , Adolescente , Adulto , Ozônio/uso terapêutico , Resultado do Tratamento , Gengivite/terapia , Doenças Periodontais , Epidemiologia Experimental , Processos Estocásticos , Gengivite/diagnóstico
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