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2.
Zhong Nan Da Xue Xue Bao Yi Xue Ban ; 45(1): 74-78, 2020 Jan 28.
Artigo em Inglês, Chinês | MEDLINE | ID: mdl-32132301

RESUMO

Gastric polyps are common precancerous diseases. With the intensive study on the characteristics of different types of gastric polyps in recent years, only 1.7% of the gastric polyps were found to have dysplasia and cancer, and most of the dysplasia and cancer were found in polyps larger than 1 cm. Traditional idea suggests that polyps should be removed immediately, but routine removal of all polyps results in an increased financial burden on patients. At present, there are controversies about whether endoscopic treatment is necessary for different pathological types and small gastric polyps.


Assuntos
Pólipos , Lesões Pré-Cancerosas , Humanos , Hiperplasia , Neoplasias Gástricas
3.
Anticancer Res ; 40(2): 789-794, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-32014921

RESUMO

BACKGROUND/AIM: To investigate tumor suppression as an indicator of malignization potential within endometrial polyps in asymptomatic postmenopausal women. MATERIALS AND METHODS: Immunohistochemical studies of the phosphatase and tensin homolog (PTEN) were performed. Cases included 52 benign postmenopausal polyps, 19 endometrioid carcinomas with coexisting benign polyps, and 12 polyps with foci of carcinoma. Controls included 31 atrophic endometria and 32 benign premenopausal polyps. PTEN was scored by quantitative methods according to staining intensity. RESULTS: The mean epithelial and stromal PTEN H-score in postmenopausal benign endometrial polyps (193.8 and 123.2, respectively) was significantly higher than that in the atrophic endometrium (135.5 and 90.2, p=0.008), and premenopausal benign endometrial polyps (100.7 and 198.7, p<0.001). Significant difference between postmenopausal endometrial polyps and endometrial carcinoma was noticed in the epithelial compartment (193.8 vs. 65.7, respectively, p<0.001). CONCLUSION: Asymptomatic benign postmenopausal polyps have a distinctively high tumor suppression compared with endometrial cancer, suggesting low malignization potential.


Assuntos
Neoplasias do Endométrio/tratamento farmacológico , Pólipos/tratamento farmacológico , Neoplasias do Endométrio/patologia , Feminino , Humanos , Pólipos/patologia , Pós-Menopausa , Estudos Retrospectivos
5.
Cancer Sci ; 111(1): 137-147, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31724799

RESUMO

As a member of the epidermal growth factor receptor (EGFR) family, ERBB3 plays an essential role in development and disease independent of inherently inactive kinase domain. Recently, ERBB3 has been found to bind to ATP and has catalytic activity in vitro. However, the biological function of ERBB3 kinase activity remains elusive in vivo. Here we have identified the physiological function of inactivated ERBB3 kinase activity by creating Erbb3-K740M knockin mice in which ATP cannot bind to ERBB3. Unlike Erbb3 knockout mice, kinase-inactive Erbb3K740M homozygous mice were born in Mendelian ratios and showed normal development. After dextran sulfate sodium-induced colitis, the kinase-inactive Erbb3 mutant mice showed normal recovery. However, the outgrowth of ileal organoids by neuregulin-1 treatment was more attenuated in Erbb3 mutant mice than in WT mice. Moreover, in combination with the ApcMin mouse, the proportion of polyps less than 1 mm in diameter in mutant mice was higher than in control mice and an increase in the number of apoptotic cells was observed in polyps from mutant mice compared with polyps from control mice. Taken together, the ERBB3 kinase activity contributes to the outgrowth of ileal organoids and intestinal tumorigenesis, and the development of ERBB3 kinase inhibitors, including epidermal growth factor receptor family members, can be a potential way to target colorectal cancer.


Assuntos
Carcinogênese/metabolismo , Carcinogênese/patologia , Intestinos/patologia , Organoides/metabolismo , Organoides/patologia , Receptor ErbB-3/metabolismo , Animais , Apoptose/efeitos dos fármacos , Apoptose/fisiologia , Carcinogênese/efeitos dos fármacos , Neoplasias Colorretais/tratamento farmacológico , Neoplasias Colorretais/metabolismo , Neoplasias Colorretais/patologia , Intestinos/efeitos dos fármacos , Camundongos , Camundongos Knockout , Organoides/efeitos dos fármacos , Fosforilação/efeitos dos fármacos , Fosforilação/fisiologia , Pólipos/tratamento farmacológico , Pólipos/patologia , Inibidores de Proteínas Quinases/farmacologia
7.
Eur Radiol ; 30(1): 206-212, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31399751

RESUMO

OBJECTIVES: To evaluate the intraobserver and interobserver reliability of gallbladder polyp measurements using transabdominal US and the factors that affect reliability. METHODS: From November 2017 to February 2018, two radiologists measured the maximum diameter of 91 gallbladder polyps using transabdominal US. Intraobserver and interobserver agreement were determined using 95% Bland-Altman limits of agreement and intraclass correlation coefficients (ICCs). The effects of image settings, polyp location, and polyp size were evaluated by comparing ICCs using z tests. RESULTS: The intraobserver agreement rates were 0.960 (95% confidence interval [CI], 0.939-0.973) for observer 1 and 0.962 (95% CI, 0.943-0.975) for observer 2. The ICCs between the two observers were 0.963 (95% CI, 0.926-0.979) for the first measurement and 0.973 (95% CI, 0.950-0.984) for the second measurement. The 95% limits of agreement on repeated measurements were 22.3-25.2% of the mean, and those between the two observers were 25.5-34.2% of the mean. ICCs for large polyps (≥ 5 mm) were significantly higher than those for small polyps (< 5 mm). There were no significant differences in the ICCs between image settings and polyp location. CONCLUSIONS: Polyp size measurements using transabdominal US are highly repeatable and reproducible. Polyp size significantly affects the reliability of measurement. Diameter changes of approximately less than 25% may fall within the measurement error; this should be considered while interpreting the change in size during follow-up US, especially for small polyps. KEY POINTS: • Gallbladder polyp size measurement using transabdominal US is highly repeatable and reproducible. • Diameter changes of approximately less than 25% should be interpreted carefully, especially in small polyps.


Assuntos
Doenças da Vesícula Biliar/diagnóstico por imagem , Pólipos/diagnóstico por imagem , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Variações Dependentes do Observador , Reprodutibilidade dos Testes , Ultrassonografia , Adulto Jovem
8.
Einstein (Sao Paulo) ; 18: eAO4916, 2020.
Artigo em Inglês, Português | MEDLINE | ID: mdl-31851226

RESUMO

OBJECTIVE: To investigate the prevalence and intensity of pain perception during diagnostic hysteroscopy in women and potential related factors. METHODS: A total of 489 women were investigated at an infertility clinic. Fluid diagnostic hysteroscopy was performed without analgesia or anesthesia by gynecologists with different levels of experience in operative hysteroscopy, using a 2.9mm rigid scope. The Visual Analog Scale was used to score pain intensity after vaginal speculum insertion and after hysteroscopy. Data collected included age, ethnicity, body mass index, history of infertility and endometrial surgery (curettage and/or hysteroscopy), smoking habits, and hysteroscopy diagnosis. Only the state of anxiety was assessed by the State-Trait Anxiety Inventory given to each patient before the procedure. RESULTS: Hysteroscopy median (25th to 75th) Visual Analog Scale scored 3.3 (3 to 5), and 41.7% of the women referred Visual Analog Scale score ≥4. Median (25th to 75th) State-Trait Anxiety Inventory score was 42 (38 to 45), and 58.3% of the women referred State-Trait Anxiety Inventory score >40. Hysteroscopy Visual Analog Scale score was significantly correlated to surgeon experience and to vaginal speculum insertion but not to State-Trait Anxiety Inventory score, ethnicity or abnormal hysteroscopic findings. CONCLUSION: Diagnostic hysteroscopy was mostly perceived as a mild discomfort procedure by most women. Nevertheless, in a considerable number of cases, women perceived hysteroscopy as painful. Pain perception was linked to individual pain threshold and surgeon experience, but not to pre-procedural anxiety state levels, ethnicity or abnormal hysteroscopic findings.


Assuntos
Histeroscopia/efeitos adversos , Medição da Dor/estatística & dados numéricos , Percepção da Dor , Dor Processual/epidemiologia , Dor Processual/etiologia , Adulto , Ansiedade/psicologia , Índice de Massa Corporal , Brasil/epidemiologia , Feminino , Humanos , Histeroscopia/psicologia , Pessoa de Meia-Idade , Medição da Dor/psicologia , Dor Processual/psicologia , Pólipos/cirurgia , Prevalência , Escalas de Graduação Psiquiátrica , Valores de Referência , Estatísticas não Paramétricas , Doenças Uterinas/cirurgia , Escala Visual Analógica , Adulto Jovem
10.
Vestn Otorinolaringol ; 84(5): 73-75, 2019.
Artigo em Russo | MEDLINE | ID: mdl-31793531

RESUMO

Lymphangiomatous polyps of palatine tonsils are a rare condition, which is diagnosed with patomorphological study. About cases in total are reported in the literature, mostly with one-sided lesions. We managed to find only two reports of lymphangiomatous polyps of palatine tonsils in the available literature. The patients were children in both cases. We report our two cases of children with lymphangiomatous polyps of palatine tonsils.


Assuntos
Pólipos , Criança , Humanos , Tonsila Palatina , Neoplasias Tonsilares
11.
J Exp Ther Oncol ; 13(2): 125-129, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31881128

RESUMO

Objective: We searched thiol/disulphide homeostasis and ischemia modified albumin (IMA) in patients with and without endometrial polyp (EP) to evaluate whether there is an association between serum oxidative stress markers and EPs. Methods: A total of 87 women were enrolled into this study. All patients were evaluated with office hysteroscopy, and then those with EPs underwent operative hysteroscopy. 43 of these women had pathologically confirmed EPs (study group) and 44 had not (control group). Fasting blood samples were obtained from the antecubital vein before the procedure in all women. Thiol/disulphide levels were analyzed with a newly developed method by Erel et al. IMA measurement was performed using an indirect method based on the colorimetric assay as previously defined. Results: There were no significant differences between the 2 groups in terms of demographic characteristics including age, body mass index, and past obstetric history. Similarly no significant difference was observed regarding infertility ratio and smoking status. Native thiol, total thiol, and disulphide levels were found to be 263.6±63.3 µmol/l vs. 280.9±63.8 µmol/l (p:0.208), 296.9±64.9 µmol/l vs. 315.2±67.3 µmol/l (p:0.202), and 16.6±6.5 µmol/l vs.17.1±7.8 µmol/l ( p:0.759) in the study and control groups, respectively. There was also no significant difference with regard to serum IMA level (46.5±12.1 vs. 44.9±12.6; p: 0.539). Conclusion: Serum thiol/disulphide homeostasis and IMA levels have no significant effect in the pathogenesis of EPs.


Assuntos
Dissulfetos , Homeostase , Estresse Oxidativo , Pólipos , Albumina Sérica , Doenças Uterinas , Biomarcadores , Estudos de Casos e Controles , Feminino , Humanos , Pólipos/metabolismo , Gravidez , Compostos de Sulfidrila , Doenças Uterinas/metabolismo
12.
Pan Afr Med J ; 33: 211, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31693718

RESUMO

Introduction: Different diagnostic tools are available to evaluate endometrial focal lesion such as hysteroscopy, sonohystrography and transvaginal ultrasound. The present study aimed to determine the diagnostic value of saline infusion sonohystrography (SIS) in diagnosis of intrauterine lesions in women with Abnormal Uterine Bleeding (AUB). Methods: This cross-sectional study recruited 100 married women with chief complain of AUB referred to gynecologic clinics at the Amir Al-Momenin hospital, Semnan, Iran from March 2014 to February 2016. All participants were in the reproductive age and post-menopausal period that showed abnormal endometrial thickness or endometrial focal lesions through transvaginal ultrasound. Participants underwent SIS, hysteroscopy plus focal lesion resection and endometrial biopsy in order. The gold standard was the histopathology of endometrial specimen reported by pathologist. Results: Mean±SD age of women was 41.2±11.3 years. To diagnose the overall focal lesions, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the SIS were 79.6, 89.1, 89.6, and 78.8% respectively. These figures were 75.0, 87.5, 82.5 and 81.7%, respectively to diagnose polyps. The SIS sensitivity, specificity, PPV and NPV values to diagnose the myomas were 60.0, 97.8, 75.0, and 95.7% respectively. Conclusion: Findings show that, SIS probably is a proper method for detecting endometrial focal lesion including polyps and myomas. Future studies may help to define further advantages of this procedure.


Assuntos
Histeroscopia/métodos , Solução Salina/administração & dosagem , Doenças Uterinas/diagnóstico , Hemorragia Uterina/etiologia , Adulto , Estudos Transversais , Feminino , Humanos , Irã (Geográfico) , Leiomioma/diagnóstico , Leiomioma/patologia , Leiomioma/cirurgia , Pessoa de Meia-Idade , Pólipos/diagnóstico , Pólipos/patologia , Valor Preditivo dos Testes , Sensibilidade e Especificidade , Ultrassonografia/métodos , Doenças Uterinas/patologia , Doenças Uterinas/cirurgia , Neoplasias Uterinas/diagnóstico , Neoplasias Uterinas/patologia , Neoplasias Uterinas/cirurgia
13.
J Med Life ; 12(3): 266-270, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31666829

RESUMO

The peculiarities of the microbiocenosis of the uterine cavity in 184 patients of reproductive age with different types of endometrial hyperproliferative processes were studied: Group 1, n=60, non-atypical endometrial hyperplasia (NAEH); Group 2, n=62, endometrial polyps (EPs); Group 3, n=62, NAEH + EPs. Correlation analysis of the degree of association between different biological media (uterus and genital tract) was carried out. Contamination of the uterine cavity by bacterial flora was diagnosed in all groups of patients examined. Anaerobic flora was about 30% while bacteria of the genus Bacteroides were the most common. Among aerobic organisms, representatives of the Enterobacteriaceae family and coccal flora are noted. The widest was the spectrum of isolated microorganisms in patients of group 2 (with endometrial polyps). A strong positive correlation was established between indices of genital tract contamination and the uterine cavity by coccal flora, Escherichia coli, and anaerobic organisms. The findings suggest dysbiotic changes and the presence of a chronic inflammatory focus in the endometrium, which pathogenetically substantiates the application of anti-inflammatory therapy in such patients.


Assuntos
Endométrio/patologia , Útero/microbiologia , Útero/patologia , Adulto , Feminino , Humanos , Pessoa de Meia-Idade , Pólipos/patologia , Neoplasias Uterinas/patologia
15.
Curr Med Sci ; 39(5): 816-819, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31612401

RESUMO

Sometimes endometrial polyps, submucosal myomas, and endometrial cancer show similar findings under ultrasonography. The aim of this study was to assess the antidiastole value of blood flow parameters using three-dimensional (3D) power Doppler ultrasonography angiography (PDA) between endometrial cancer and uterine parenchyma lumps. The data of the blood flow indices in 3D-PDA including the vascularization index (VI), flow index (FI), and vascularization flow index (VFI) in 40 patients with endometrial cancer and 41 patients with uterine parenchyma lumps (endometrial polyps and submucosal myomas) were retrospectively analysed and compared utilizing Virtual Organ Computer-aided AnaLysis (VOCAL) software. The results showed that all the blood flow parameters (VI, FI, VFI) were significantly higher in women with endometrial cancer than in those with uterine parenchyma lumps (P<0.001). The area under the curve of ROC of VI, FI, and VFI was 0.98, 0.84, and 0.97, respectively. Thus, the best predictor of endometrial carcinoma was VI with a sensitivity of 97.0% and a specificity of 91.0%. The optimal cutoff value of VI was 4.06%. Our data demonstrated that all of the blood flow signal parameters (including VI, FI, and VFI) in 3D power Doppler ultrasonography had significant antidiastole values between endometrial cancer and uterine parenchyma lumps to assist clinicians in properly diagnosing patients.


Assuntos
Carcinoma/diagnóstico por imagem , Neoplasias do Endométrio/diagnóstico por imagem , Interpretação de Imagem Assistida por Computador/estatística & dados numéricos , Mioma/diagnóstico por imagem , Pólipos/diagnóstico por imagem , Adulto , Angiografia/estatística & dados numéricos , Área Sob a Curva , Velocidade do Fluxo Sanguíneo , Carcinoma/irrigação sanguínea , Carcinoma/patologia , Diagnóstico Diferencial , Neoplasias do Endométrio/irrigação sanguínea , Neoplasias do Endométrio/patologia , Endométrio/irrigação sanguínea , Endométrio/diagnóstico por imagem , Endométrio/patologia , Feminino , Humanos , Imagem Tridimensional , Pessoa de Meia-Idade , Mioma/irrigação sanguínea , Mioma/patologia , Pólipos/patologia , Curva ROC , Estudos Retrospectivos , Sensibilidade e Especificidade , Software , Ultrassonografia Doppler/estatística & dados numéricos
16.
Acta Gastroenterol Belg ; 82(3): 437-439, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31566334

RESUMO

Giant fibrovascular polyps of the esophagus are rare benign tumors that originate at the hypopharynx or the upper third of the esophagus. Because of the indolent and benign nature they are mostly discovered when very large with symptoms like dysphagia or regurgitation of the polyp into the mouth which can cause asphyxia and dead. The removal of these polyps is obligatory. Although more than 100 cases of giant fibrovascular esophageal polyps have been described in literature so far, the approach for removal is not yet standard and needs a customized use of medical technology from different disciplines. We present the case of a 42 year old man in whom a giant polyp was removed transorally by a combination of instruments and materials from different disciplines (gastroenterological, surgical and laryngological).


Assuntos
Transtornos de Deglutição/etiologia , Neoplasias Esofágicas/cirurgia , Pólipos/cirurgia , Adulto , Neoplasias Esofágicas/patologia , Humanos , Masculino , Boca , Pólipos/diagnóstico , Resultado do Tratamento
19.
Medicine (Baltimore) ; 98(40): e17183, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31577708

RESUMO

This study aimed to compare the quality of histological endometrial samples collected through Pipelle aspiration and hysteroscopic biopsies to assess the agreement between these 2 biopsies in the histological diagnosis of malignancy and to compare the costs of both biopsies.This was a cross-sectional study. Forty-five women were biopsied, first using Pipelle and immediately after using hysteroscopy. The material collected was sent for analysis, and hysteroscopy was considered the gold standard. The results were divided into the following 3 categories: normal (atrophic, proliferative, and secretory endometrium); polyps; and malignancies. We report the agreement between Pipelle and hysteroscopy in the diagnosis of malignancy and compare their costs.The study showed that while analyzing endometrial malignancies, Pipelle sampling had 100% sensitivity and specificity. In the detection of polyps, Pipelle sampling showed 26.1% sensitivity, 88.9% specificity, 75% positive predictive value, 48.5% negative predictive value, and 53.7% accuracy. Agreement with hysteroscopy in the diagnosis of malignancy was 100%. The Pipelle device costs 27 times less than hysteroscopic biopsy for health insurance companies. This cost is 13.7 times lower in the Brazilian Unified Health System.Endometrial biopsies using the Pipelle have a high accuracy for endometrial cancer and a low accuracy for polyps. We detected 100% agreement between the reports of Pipelle and hysteroscopy with regard to malignancy. Pipelle is the most cost-effective method of endometrial biopsy.


Assuntos
Biópsia por Agulha/métodos , Neoplasias do Endométrio/patologia , Endométrio/patologia , Histeroscopia/métodos , Adulto , Idoso , Biópsia por Agulha/economia , Biópsia por Agulha/normas , Brasil , Estudos Transversais , Feminino , Humanos , Histeroscopia/economia , Histeroscopia/normas , Menopausa/fisiologia , Pessoa de Meia-Idade , Pólipos , Sensibilidade e Especificidade
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