Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 613
Filtrar
1.
Pan Afr Med J ; 38: 146, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33912316

RESUMO

Pleomorphic adenoma is a benign mixed tumor, which is composed of myoepithelial and epithelial cells. A fibrous capsule separates these cells from the surrounding tissues. Pleomorphic adenoma is the most common salivary gland tumour accounting for 40-70% of all major and minor salivary gland tumours. It is also the commonest minor salivary gland benign tumours accounting for 70% of all tumours. Hard palate is the commonest site followed by upper lip, buccal mucosa, tongue, floor of mouth, retromolar trigone. This case report discusses a case of pleomorphic adenoma of hard palate in an old man after complete excision of the tumour, which was confirmed by a biopsy specimen.


Assuntos
Adenoma Pleomorfo/diagnóstico , Neoplasias Palatinas/diagnóstico , Palato Duro/patologia , Adenoma Pleomorfo/patologia , Adenoma Pleomorfo/cirurgia , Adulto , Humanos , Masculino , Neoplasias Palatinas/patologia , Neoplasias Palatinas/cirurgia , Palato Duro/cirurgia
2.
Pan Afr Med J ; 38: 61, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33889227

RESUMO

Fibromas are benign tumors of connective tissue common in the oral cavity but rare on hard palate. This paper reports on an asymptomatic, slowly growing mass on the hard palate of a 90-year-old lady, with a reported use of denture for two decades. The patient presented with a 2.2cm, smooth-surfaced, well-circumscribed nodule attached with a stalk to the palatal mucosa. After excision, the histopathological examination revealed a mass of fibrous connective tissue, covered by stratified squamous epithelium with focal low-medium grade hyperplasia and hyperkeratosis. These findings were consistent with irritation fibroma of hard palate, a rare entity, which should be considered as a possible diagnosis for tumors of the area by every physician.


Assuntos
Fibroma/diagnóstico , Neoplasias Palatinas/diagnóstico , Palato Duro/patologia , Idoso de 80 Anos ou mais , Feminino , Fibroma/patologia , Fibroma/cirurgia , Humanos , Hiperplasia , Neoplasias Palatinas/patologia , Neoplasias Palatinas/cirurgia , Palato Duro/cirurgia
3.
Surg Pathol Clin ; 14(1): 43-51, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33526222

RESUMO

Sialadenoma papilliferum (SP) is a rare, benign salivary gland neoplasm sharing similar histopathologic features and harboring the same genetic alterations, BRAF V600E or HRAS mutations, with syringocystadenoma papilliferum. SP most commonly occurs in the hard palate and in older adults. Clinically, SP is most likely to be diagnosed as a squamous papilloma. Microscopically, SP shows an exophytic papillary epithelial proliferation and a contiguously endophytic ductal proliferation. Two distinct subtypes are identified: classic SP and oncocytic SP. Conservative surgical treatment seems to be adequate with a low recurrence. SOX10 immunohistochemistry and BRAF analysis may be useful in differential diagnosis.


Assuntos
Adenoma/patologia , Neoplasias das Glândulas Salivares/patologia , Adenoma/classificação , Adenoma/diagnóstico , Adenoma/cirurgia , Proliferação de Células , Diagnóstico Diferencial , Células Epiteliais/patologia , Humanos , Imuno-Histoquímica , Mutação , Palato Duro/patologia , Prognóstico , Proteínas Proto-Oncogênicas B-raf/genética , Fatores de Transcrição SOXE/análise , Neoplasias das Glândulas Salivares/classificação , Neoplasias das Glândulas Salivares/diagnóstico , Neoplasias das Glândulas Salivares/cirurgia , Glândulas Salivares Menores/patologia
4.
Sci Rep ; 10(1): 19074, 2020 11 05.
Artigo em Inglês | MEDLINE | ID: mdl-33154503

RESUMO

This observational study compared palatal rugae morphology in adolescent subjects with normal tooth number and tooth agenesis. Maxillary dental study casts were used to compare rugae number, length and shape. Each study group contained 60 subjects (30 females and 30 males) mean age 13.4 (SD, 1.55) in control and 13.56 (SD, 1.54) years in tooth agenesis groups (p = 0.576). Mean number of missing tooth units in the tooth agenesis group was 2.1. Mean number of primary rugae in the whole sample was 4.35 (SD, 0.98) on the right and 4.33 (SD, 0.92) on the left with no significant differences (p = 0.236 and p = 0.404, respectively). However, the number of secondary rugae on the left (p = 0.006) and fragmentary rugae on the right (p = 0.004) was significantly increased in the tooth agenesis group. The shape of left primary rugae 2 and 3 also differed between groups, tending towards a wavy pattern in the control group and curved in the tooth agenesis group (p = 0.012 and p = 0.004, respectively). In addition, primary rugae 3 was more convergent (p = 0.008) whilst left primary rugae 3 and 5 were orientated in an antero-posterior direction (p = 0.04 for both rugae) in the tooth agenesis group. Subgroup analysis also identified significant associations between patterns of tooth agenesis and rugae number, in addition to shape of primary rugae. The identification of significant differences in rugae pattern between subjects with normal tooth number and agenesis suggests potential commonality in signal pathway disruption during establishment of these structures.


Assuntos
Anodontia/patologia , Palato Duro/anatomia & histologia , Palato Duro/patologia , Adolescente , Criança , Estudos de Coortes , Técnica de Fundição Odontológica , Modelos Dentários , Feminino , Humanos , Masculino
5.
Plast Reconstr Surg ; 146(6): 1331-1339, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-33234964

RESUMO

BACKGROUND: For the cleft surgeon, palatal fistulae after cleft palate repair remain a difficult problem, with a paucity of local tissue options to aid closure. Small clinical series have described the use of the buccal fat pad flap to repair palatal fistulae; however, there is no literature detailing the anatomical coverage of the flap. This study delineates the anatomy of the buccal fat pad flap to guide surgeons in patient selection and examines the residual buccal fat after flap harvest to provide new information with regard to possible effects on the donor site. METHODS: Buccal fat pad flaps were raised in 30 hemicadavers. The reach of the flap across the midline, anteriorly and posteriorly, was recorded. In 18 hemicadavers, the entire buccal fat pad was then exposed to determine the effects of flap harvest on movement and volume of the residual fat. RESULTS: All buccal fat pad flaps provided coverage from the soft palate to the posterior third of the hard palate and all across the midline. Approximately three-fourths of flaps would cover the mid hard palate. The flap constitutes 36 percent of the total buccal fat pad on average, and a series of retaining ligaments were identified that may prevent overresection. CONCLUSIONS: The buccal fat pad flap is a useful tool for coverage of fistulae in the soft palate to the posterior third of the hard palate. In most cases, it will also reach the middle third; however, it is not suitable for more anterior defects. On average, two-thirds of the buccal fat pad remains within the cheek after flap harvest, which may protect against unwanted alteration in aesthetics.


Assuntos
Bochecha/cirurgia , Fístula/cirurgia , Procedimentos Cirúrgicos Bucais/efeitos adversos , Coleta de Tecidos e Órgãos/efeitos adversos , Sítio Doador de Transplante/cirurgia , Tecido Adiposo/transplante , Cadáver , Bochecha/anatomia & histologia , Estética , Estudos de Viabilidade , Fístula/patologia , Humanos , Procedimentos Cirúrgicos Bucais/métodos , Palato Duro/patologia , Palato Duro/cirurgia , Palato Mole/patologia , Palato Mole/cirurgia , Seleção de Pacientes , Retalhos Cirúrgicos/efeitos adversos , Retalhos Cirúrgicos/transplante , Coleta de Tecidos e Órgãos/métodos , Sítio Doador de Transplante/anatomia & histologia
6.
Clin Nucl Med ; 45(10): 811-812, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32804762

RESUMO

Langerhans cell histiocytosis (LCH) is rare in adults. Oral and maxillofacial LCH commonly affects the bones of the skull and jaws. Here we report a case of a 57-year-old man with a painless oral mass evaluated by F-FDG PET/CT. PET/CT showed a solitary F-FDG-avid tumor in his left hard palate. LCH was confirmed after surgery. This case reminds us that LCH should be considered in an adult with hypermetabolic hard palate lesion on F-FDG PET/CT.


Assuntos
Histiocitose de Células de Langerhans/diagnóstico por imagem , Palato Duro/diagnóstico por imagem , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Fluordesoxiglucose F18 , Histiocitose de Células de Langerhans/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Palato Duro/patologia
7.
J Craniofac Surg ; 31(6): e612-e614, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32649529

RESUMO

As the authors recently experienced a patient with pyogenic granuloma arising from the hard palate, they tried to review all the previously reported literatures with the emphasis on its clinical characteristics that can help the accurate diagnosis of this unusual lesion. Based on our experience and literatures review, clinicians should keep in mind that pyogenic granuloma should be taken into consideration in the differential diagnosis of the hard palatal mass despite its rarity. Although histopathological examination of the mass is the only way to arrive at a definitive diagnosis, the knowledge of the gross appearances of pyogenic granuloma with clinical features may be helpful for differential diagnosis.


Assuntos
Granuloma Piogênico/diagnóstico , Palato Duro , Adulto , Diagnóstico Diferencial , Humanos , Masculino , Úlceras Orais/diagnóstico , Palato Duro/patologia
9.
Ann R Coll Surg Engl ; 102(8): e185-e186, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32374179

RESUMO

Autoimmune disorders and their manifestations can be very problematic to diagnose and manage. The symptoms can be ambiguous and debilitating. Early intervention is necessary to counter the unforgiving consequences of delayed intervention, such as loss of sight or hearing and destruction of affected tissues. Vasculitis in the head and neck region is rare. A case of ANCA-associated vasculitis causing extensive destruction is presented to enhance our understanding of this devastating multisystem disorder.


Assuntos
Vasculite Associada a Anticorpo Anticitoplasma de Neutrófilos , Doenças Maxilomandibulares , Palato Duro/patologia , Adulto , Feminino , Humanos , Necrose
11.
Medicina (Kaunas) ; 56(4)2020 Apr 19.
Artigo em Inglês | MEDLINE | ID: mdl-32325833

RESUMO

Bulimia is an eating disorder with a great prevalence in young women. Due to its multifactor ethiology, bulimia has systemic consequences. In the literature, necrotising sialometaplasia is seldom associated with bulimia. Its etiopathogenesis is discussed by several authors; nevertheless, the consensus does not consider the relevance of local trauma associated with induced vomiting. A case of necrotising sialomethaplasia, presented with a single hard palatal ulcer in a bulimic woman is described in the present report. The patient did not present significant systemic laboratorial values, nor physical weight variations, which highlights the relevance of performing a complete medical clinical history when diagnosing this rare pathology.


Assuntos
Bulimia Nervosa/complicações , Sialometaplasia Necrosante/etiologia , Biópsia/métodos , Feminino , Humanos , Palato Duro/patologia , Palato Duro/cirurgia , Sialometaplasia Necrosante/diagnóstico , Sialometaplasia Necrosante/patologia , Sialometaplasia Necrosante/cirurgia , Adulto Jovem
12.
BMJ Case Rep ; 13(4)2020 Apr 23.
Artigo em Inglês | MEDLINE | ID: mdl-32332045

RESUMO

An 80-year-old woman presented with a several-year history of progressive hair loss and scalp pruritus. No other rashes or muscle weakness were noted on examination. Scalp biopsy showed interface dermatitis, dense perivascular and periadnexal lymphocytic infiltrate, mucin and scarring alopecia. Laboratory analysis did not show evidence of myositis. The patient was started on hydroxychloroquine for possible cutaneous lupus erythematosus. On follow-up, she presented with a new violaceous rash on the superior eyelids and a well-defined oval patch on the mid-hard palate suspicious for dermatomyositis. Myositis-specific autoantibodies revealed presence of anti-transcriptional intermediary factor-1γ (anti-TIF1γ) in the serum. Anti-TIF1γ autoantibody-positive dermatomyositis is a newly recognised subtype of dermatomyositis that is highly associated with amyopathic disease and has an increased risk of malignancy, making prompt diagnosis crucial. This case highlights the utility of a thorough oral exam in patients suspected to have connective tissue disease as the distinctive ovoid palatal patch is nearly pathognomonic for anti-TIF1γ dermatomyositis.


Assuntos
Autoanticorpos/sangue , Dermatomiosite/diagnóstico , Eritema/patologia , Exantema/patologia , Palato Duro/patologia , Idoso de 80 Anos ou mais , Fármacos Dermatológicos/uso terapêutico , Dermatomiosite/tratamento farmacológico , Diagnóstico Diferencial , Feminino , Humanos , Metotrexato/uso terapêutico , Fatores de Transcrição/imunologia
14.
Head Neck Pathol ; 14(2): 535-541, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31230231

RESUMO

Clear cell acanthoma (CCA), also known as pale cell acanthoma, represents a rare benign epidermal tumor with strong predilection for the lower extremities of middle-aged individuals and no frank gender preference. The etiology of CCA is poorly understood, although a localized psoriasiform reaction is favored. Herein, we report on the clinicopathologic and immunohistochemical features, and HPV status of an apparent example of oral CCA. A 58-year-old female presented with a well-circumscribed, asymptomatic, exophytic, sessile and erythematous nodule of the right hard palate, measuring 0.7 cm in greatest dimension. Microscopically, the lesion featured parakeratosis and acanthosis with neutrophilic microabscesses and broad elongated rete pegs. In areas, spinous epithelial cells exhibited pale or clear cytoplasm without nuclear pleomorphism, mitoses or cytologic atypia. The supporting connective tissue revealed mild chronic inflammation with few scattered neutrophils and numerous capillary vessels. PAS histochemical stain with and without diastase disclosed the presence of cytoplasmic glycogen in the pale cells. The majority of glycogen-rich epithelial cells stained strongly for EMA and were negative for D2-40. Ki-67 immunostaining was confined only to the basal cell layer of the epithelium. A diagnosis of CCA was rendered. The lesion was negative for human papillomavirus (HPV) infection, as assessed by HPV-DNA PCR using the MY09/11 primers for the L1 conserved region, thus HPV infection does not appear to contribute to the pathogenesis of oral CCA. In conclusion, we report an intraoral example of CCA in order to raise awareness about this entity.


Assuntos
Acantoma/patologia , Neoplasias Palatinas/patologia , Palato Duro/patologia , Neoplasias Cutâneas/patologia , Feminino , Humanos , Pessoa de Meia-Idade
15.
Orbit ; 39(5): 368-373, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31718425

RESUMO

Solitary or isolated neurofibroma is uncommonly observed in the orbit. Neurofibromas typically involve peripheral nerves and occasionally the cranial nerves. A 29-year-old man presented with recent onset left eye proptosis and exotropia. Physical examination was positive for hyperpigmented lesions of the ipsilateral ocular surface and hard palate. Imaging revealed an infiltrative orbital mass with extension through superior orbital fissure into the brain. There was also bone defect of greater sphenoid wing. Medial orbitotomy was performed to obtain biopsies of the orbital mass and the pigmented ocular surface lesions. Histopathologic diagnosis of neurofibroma was confirmed for the former and melanocytoma for the latter. His symptoms and examinations remained stable during the follow up. This case is unique due to several features, including extensive intracerebral spread of orbital neurofibroma in a patient without definite diagnosis of neurofibromatosis type 1 and association with ipsilateral ocular surface melanocytoma and palatal pigmented lesions. ABBREVIATIONS: CT: computed tomography; GFAP: glial fibrillary acid protein; MRI: magnetic resonance imaging; NF-1: neurofibromatosis type 1.


Assuntos
Neoplasias Encefálicas/secundário , Neoplasias da Túnica Conjuntiva/patologia , Neurofibroma/patologia , Nevo Pigmentado/patologia , Neoplasias Orbitárias/patologia , Adulto , Neoplasias Ósseas/patologia , Neoplasias Encefálicas/diagnóstico por imagem , Neoplasias Encefálicas/cirurgia , Neoplasias da Túnica Conjuntiva/diagnóstico por imagem , Neoplasias da Túnica Conjuntiva/cirurgia , Humanos , Imageamento por Ressonância Magnética , Masculino , Neurofibroma/diagnóstico por imagem , Neurofibroma/cirurgia , Nevo Pigmentado/diagnóstico por imagem , Nevo Pigmentado/cirurgia , Procedimentos Cirúrgicos Oftalmológicos , Neoplasias Orbitárias/diagnóstico por imagem , Neoplasias Orbitárias/cirurgia , Palato Duro/patologia , Osso Esfenoide , Tomografia Computadorizada por Raios X
17.
J Surg Oncol ; 120(7): 1259-1265, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31549410

RESUMO

BACKGROUND AND OBJECTIVES: The reported risk of nodal metastasis in hard palate and upper gingival squamous cell carcinoma (SCC) has been inconsistent with inadequate consensus regarding the utility of neck dissection in the clinically negative (cN0) neck. MATERIALS AND METHODS: Using the National Cancer Database, cN0 patients diagnosed with SCC of the head and neck with the subsites of the hard palate and upper gingiva were identified from 2004 to 2014. RESULTS: A total of 1830 patients were identified, and END was performed on 422 patients with cN0 tumors. Pathologically positive nodes occurred in 14% (59/422) of patients in this cohort. Higher tumor stage, academic hospital type, and large hospital volume (>28 cancer-specific cases/year) were associated with a higher likelihood of END both in univariate and multivariate analyses (P < .05). Patients >80 years of age were less likely to receive END on multivariate analysis (OR 0.52, 0.32-0.84). No variables, including advanced T stage, predicted occult metastases. Cox proportional hazards regression analysis showed that patients who underwent END demonstrated improved OS over an 11-year period (hazard ratio 0.75, P = .002). On subgroup analysis, this improvement was significant in patients with both stage T1 and T4 tumors. CONCLUSIONS: Tumor stage, hospital type, and hospital volume were associated with higher rates of END for patients with cN0 hard palate SCC and after controlling for clinical factors, END was associated with improved overall survival.


Assuntos
Carcinoma de Células Escamosas/mortalidade , Procedimentos Cirúrgicos Eletivos/mortalidade , Neoplasias Gengivais/mortalidade , Neoplasias Maxilares/mortalidade , Esvaziamento Cervical/mortalidade , Palato Duro/cirurgia , Idoso , Idoso de 80 Anos ou mais , Carcinoma de Células Escamosas/patologia , Carcinoma de Células Escamosas/cirurgia , Bases de Dados Factuais , Feminino , Seguimentos , Neoplasias Gengivais/patologia , Neoplasias Gengivais/cirurgia , Humanos , Masculino , Neoplasias Maxilares/patologia , Neoplasias Maxilares/cirurgia , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Palato Duro/patologia , Estudos Retrospectivos , Taxa de Sobrevida
18.
Med Leg J ; 87(3): 130-132, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31294642

RESUMO

Torus palatinus (TP) is a benign, bony outgrowth located on the hard palate. Variation in this trait occurs, ranging from absent to a protuberance several millimeters in length. If a TP becomes too large, it can interfere with daily activities and thus warrant medical attention. This case utilised the unique morphology of a TP after surgical invention to identify the unknown skeletal remains of a woman missing for six years. Even though there is still much unknown regarding the aetiology, occurrence and prevalence of TP, this study demonstrates the usefulness of anatomical variants in the identification of unknown skeletal remains.


Assuntos
Restos Mortais/patologia , Exostose/patologia , Antropologia Forense/métodos , Mandíbula/anormalidades , Palato Duro/anormalidades , Grupo com Ancestrais do Continente Africano , Feminino , Patologia Legal/métodos , Humanos , Mandíbula/patologia , Michigan , Pessoa de Meia-Idade , Palato Duro/patologia
19.
Am J Otolaryngol ; 40(5): 779-782, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31285063

RESUMO

Juvenile aggressive ossifying fibromas (JAOF) are rare, typically benign pediatric tumors that are locally aggressive and have high recurrence rates. A 7-year old male presented with a palatal mass and a 3D printed model was created and used as a visual aide to highlight the importance of management in terms of functional, cosmetic, and disease-free outcomes with the family. The patient ultimately underwent successful enucleation with final pathology consistent with JAOF. To our knowledge, this is the first description of the use of 3D printing to help in the shared decision-making process for the treatment of this aggressive tumor.


Assuntos
Neoplasias Ósseas/patologia , Tomada de Decisão Compartilhada , Fibroma Ossificante/patologia , Palato Duro/patologia , Impressão Tridimensional , Neoplasias Ósseas/diagnóstico , Neoplasias Ósseas/cirurgia , Criança , Fibroma Ossificante/diagnóstico , Fibroma Ossificante/cirurgia , Humanos , Masculino , Invasividade Neoplásica/patologia , Estadiamento de Neoplasias , Palato Duro/diagnóstico por imagem , Doenças Raras , Medição de Risco , Resultado do Tratamento
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...