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1.
J Med Case Rep ; 17(1): 5, 2023 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-36609451

RESUMO

BACKGROUND: Collagenous fibroma or desmoplastic fibroblastoma is a rare benign fibrous tissue tumor. It usually presents as a painless, slowly growing mass. Collagenous fibroma arises ordinarily inside the subcutaneous tissues or skeletal muscles. Histopathologically, the tumor consists of scattered stellate and spindle cells in a hypovascular collagenous stroma without atypia or infiltration. The oral cavity is a very uncommon site for desmoplastic fibroblastoma. Only 15 published articles in the literature reported the intraoral location. We present a case of collagenous fibroma with a bilateral distribution on the hard palate. This is the second case of bilateral collagenous fibroma after a previously reported one in literature; however, our case was larger, occupying almost the whole palate. We discuss the management of this rare tumor and how we can reach definite diagnosis. CASE PRESENTATION: A 37-year-old Caucasian female patient had a huge bilateral firm palatal mass that caused breathing problems. There was no history of trauma and the patient had no relevant medical history Total surgical excision under general anesthesia was carried out and histopathological examination suggested a benign mesenchymal tumor. Immunohistochemistry was necessary to confirm the tumor origin and to exclude aggressive fibromatosis. A diagnosis of bilateral collagenous fibroma was reached. Six months after surgery, there was no recurring lesion and the patient's health was good. CONCLUSIONS: Collagenous fibroma is a benign fibrous tissue tumor of unknown cause that is treated with simple excision. The prognosis is good with no recurrence. Reaching an accurate diagnosis is mandatory to avoid aggressive treatment since collagenous fibroma may be misdiagnosed as aggressive fibromatosis in case of massive size. Clinicians and pathologists should be aware of this unusual tumor for conservative management without side effects.


Assuntos
Fibroma Desmoplásico , Fibroma , Fibromatose Agressiva , Neoplasias de Tecidos Moles , Humanos , Feminino , Adulto , Fibroma Desmoplásico/diagnóstico por imagem , Fibroma Desmoplásico/cirurgia , Palato Duro/diagnóstico por imagem , Palato Duro/cirurgia , Palato Duro/patologia , Fibroma/patologia , Fibroma/cirurgia , Neoplasias de Tecidos Moles/cirurgia
2.
Medicina (Kaunas) ; 58(12)2022 Dec 09.
Artigo em Inglês | MEDLINE | ID: mdl-36557012

RESUMO

Kimura's disease (KD) is a rare chronic inflammatory disorder that commonly occurs in Asian males. It mainly presents as painless subcutaneous masses or lymphadenopathy in the head and neck region. The incidence of KD in the oral cavity is quite rare. We reported a rare case of a 53-year-old male who had KD in his soft palate, hard palate and bilateral tonsils associated with severe sleep apnea. This patient underwent radiotherapy and exhibited a good response to the treatment. Throughout the 12-month follow-up period, the patient's condition remained satisfactory. Of the other 14 reviewed cases of KD in the oral cavity, the lesions can occur in the buccal mucosa, hard and soft palate, and mouth floor with specific clinical features. We further summarized their manifestations and treatments in order to guide the future identification and management of KD with lesions in the oral cavity.


Assuntos
Hiperplasia Angiolinfoide com Eosinofilia , Doença de Kimura , Masculino , Humanos , Pessoa de Meia-Idade , Hiperplasia Angiolinfoide com Eosinofilia/complicações , Hiperplasia Angiolinfoide com Eosinofilia/diagnóstico , Hiperplasia Angiolinfoide com Eosinofilia/patologia , Doença de Kimura/complicações , Doença de Kimura/patologia , Palato Duro/patologia , Mucosa Bucal/patologia , Doenças Raras/patologia
3.
J Investig Med High Impact Case Rep ; 10: 23247096221142275, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36546664

RESUMO

Solitary fibrous tumor (SFT) is a mesenchymal tumor accounting for less than 2% of soft tissue tumors and has variable clinical behavior. It can arise in many anatomical locations of the body and in rare occasions in the oral cavity mostly in buccal mucosa and tongue. To date, a handful of such cases have been reported in the hard palate. We present a case of SFT in the hard palate of a 32-year-old man and describe the tissue morphology, immunohistochemistry workup, and follow-up together with literature review.


Assuntos
Palato Duro , Tumores Fibrosos Solitários , Masculino , Humanos , Adulto , Palato Duro/patologia , Tumores Fibrosos Solitários/diagnóstico por imagem , Tumores Fibrosos Solitários/cirurgia , Língua/patologia , Imuno-Histoquímica
4.
J Investig Med High Impact Case Rep ; 10: 23247096221133989, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36300426

RESUMO

Extrahepatic metastasis of hepatocellular carcinoma (HCC) to the head and neck is unusual, especially the oral cavity/maxillofacial region. Metastatic HCC to the hard palate, however, is particularly rare. The most common site of HCC metastasis is the lung, followed by lymph nodes, bone, and adrenal gland. Importantly, oral cavity metastatic HCC may be misdiagnosed as a primary malignancy, such as a salivary gland carcinoma. In this article, we describe a young woman with metastatic HCC to the hard palate that was initially diagnosed as an acinic cell carcinoma.


Assuntos
Carcinoma de Células Acinares , Carcinoma Hepatocelular , Neoplasias Hepáticas , Feminino , Humanos , Carcinoma Hepatocelular/diagnóstico , Carcinoma Hepatocelular/patologia , Carcinoma Hepatocelular/secundário , Neoplasias Hepáticas/patologia , Palato Duro/patologia , Linfonodos/patologia , Carcinoma de Células Acinares/patologia
5.
Clin J Gastroenterol ; 15(4): 708-711, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-35429332

RESUMO

The most common sites of metastasis from colorectal cancer are liver, lungs, and peritoneum. Oral cavity metastasis is extremely rare, accounting for only 1-2% of all oral cancers. We report the case of a 71-year-old male who presented with hard palate metastasis 20 months after his initial diagnosis for T4N1M1 rectal adenocarcinoma according to the UICC TNM classification. To the best of our knowledge, hard palate metastasis from colorectal cancer has never been previously reported in the literature. The hard palate metastasis deteriorates oral function, resulted in unfavorable prognosis. Early detection of oral cavity metastasis could lead to the opportunities for additional treatment and improve outcomes following treatment.


Assuntos
Adenocarcinoma , Neoplasias Retais , Adenocarcinoma/patologia , Idoso , Humanos , Masculino , Estadiamento de Neoplasias , Palato Duro/patologia , Prognóstico , Neoplasias Retais/patologia
8.
Pan Afr Med J ; 38: 61, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33889227

RESUMO

Fibromas are benign tumors of connective tissue common in the oral cavity but rare on hard palate. This paper reports on an asymptomatic, slowly growing mass on the hard palate of a 90-year-old lady, with a reported use of denture for two decades. The patient presented with a 2.2cm, smooth-surfaced, well-circumscribed nodule attached with a stalk to the palatal mucosa. After excision, the histopathological examination revealed a mass of fibrous connective tissue, covered by stratified squamous epithelium with focal low-medium grade hyperplasia and hyperkeratosis. These findings were consistent with irritation fibroma of hard palate, a rare entity, which should be considered as a possible diagnosis for tumors of the area by every physician.


Assuntos
Fibroma/diagnóstico , Neoplasias Palatinas/diagnóstico , Palato Duro/patologia , Idoso de 80 Anos ou mais , Feminino , Fibroma/patologia , Fibroma/cirurgia , Humanos , Hiperplasia , Neoplasias Palatinas/patologia , Neoplasias Palatinas/cirurgia , Palato Duro/cirurgia
9.
Pan Afr Med J ; 38: 146, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33912316

RESUMO

Pleomorphic adenoma is a benign mixed tumor, which is composed of myoepithelial and epithelial cells. A fibrous capsule separates these cells from the surrounding tissues. Pleomorphic adenoma is the most common salivary gland tumour accounting for 40-70% of all major and minor salivary gland tumours. It is also the commonest minor salivary gland benign tumours accounting for 70% of all tumours. Hard palate is the commonest site followed by upper lip, buccal mucosa, tongue, floor of mouth, retromolar trigone. This case report discusses a case of pleomorphic adenoma of hard palate in an old man after complete excision of the tumour, which was confirmed by a biopsy specimen.


Assuntos
Adenoma Pleomorfo/diagnóstico , Neoplasias Palatinas/diagnóstico , Palato Duro/patologia , Adenoma Pleomorfo/patologia , Adenoma Pleomorfo/cirurgia , Adulto , Humanos , Masculino , Neoplasias Palatinas/patologia , Neoplasias Palatinas/cirurgia , Palato Duro/cirurgia
10.
Surg Pathol Clin ; 14(1): 43-51, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-33526222

RESUMO

Sialadenoma papilliferum (SP) is a rare, benign salivary gland neoplasm sharing similar histopathologic features and harboring the same genetic alterations, BRAF V600E or HRAS mutations, with syringocystadenoma papilliferum. SP most commonly occurs in the hard palate and in older adults. Clinically, SP is most likely to be diagnosed as a squamous papilloma. Microscopically, SP shows an exophytic papillary epithelial proliferation and a contiguously endophytic ductal proliferation. Two distinct subtypes are identified: classic SP and oncocytic SP. Conservative surgical treatment seems to be adequate with a low recurrence. SOX10 immunohistochemistry and BRAF analysis may be useful in differential diagnosis.


Assuntos
Adenoma/patologia , Neoplasias das Glândulas Salivares/patologia , Adenoma/classificação , Adenoma/diagnóstico , Adenoma/cirurgia , Proliferação de Células , Diagnóstico Diferencial , Células Epiteliais/patologia , Humanos , Imuno-Histoquímica , Mutação , Palato Duro/patologia , Prognóstico , Proteínas Proto-Oncogênicas B-raf/genética , Fatores de Transcrição SOXE/análise , Neoplasias das Glândulas Salivares/classificação , Neoplasias das Glândulas Salivares/diagnóstico , Neoplasias das Glândulas Salivares/cirurgia , Glândulas Salivares Menores/patologia
11.
Arq. bras. med. vet. zootec. (Online) ; 73(1): 207-213, Jan.-Feb. 2021. tab, ilus
Artigo em Inglês | LILACS, VETINDEX | ID: biblio-1153062

RESUMO

The osteosarcoma (OSA) is the most diagnosed primary bone cancer in canine patients. This work reports a case of a canine, six years old, mongrel, female, intact, with an OSA in the hard palate. Physical examination detected a firm mass in the palate. Thoracic radiographs, hematological and biochemical exams, histopathological exams and computed tomography were requested. A chondroblastic OSA was diagnosed and the tumor was characterized by immunohistochemistry. There was never evidence of metastasis in this case. The treatment consisted of the combination of conventional chemotherapy, metronomic chemotherapy, and palliative care, aiming at greater survival and well-being of the patient since surgical excision was not possible due to the location and extension of the tumor. Osteogenic sarcomas of the hard palate are rarely seen and described in the literature. In this article we present a characterization of the osteosarcoma with uncommon localization in the hard palate.(AU)


O osteossarcoma (OSA) é a neoplasia óssea primária mais diagnosticada em pacientes caninos. Este trabalho relata o caso de um canino, com seis anos de idade, sem raça definida, fêmea, não castrado, apresentando OSA em região de palato duro. Ao exame clínico, constatou-se uma massa de consistência firme em região palatina. Além do exame clínico, foram solicitadas radiografias torácicas, exames hematológicos e bioquímicos, exames histopatológicos e tomografia computadorizada. Fora então dado o diagnóstico de OSA condroblástico, e o tumor foi caracterizado pela imuno-histoquímica. Não foram observadas evidências de metástases nesse caso. O tratamento instituído consistiu na combinação de quimioterapia convencional, quimioterapia metronômica e cuidados paliativos, almejando maior sobrevida e bem-estar do paciente, uma vez que a excisão cirúrgica não foi possível devido à localização e à extensão do tumor. Neste artigo, apresentou-se uma caracterização do osteossarcoma com localização incomum no palato duro.(AU)


Assuntos
Animais , Cães , Osteossarcoma/veterinária , Osteossarcoma/diagnóstico por imagem , Palato Duro/patologia , Imuno-Histoquímica/veterinária , Neoplasias Palatinas/veterinária
14.
Am J Hum Biol ; 33(2): e23446, 2021 03.
Artigo em Inglês | MEDLINE | ID: mdl-32537788

RESUMO

OBJECTIVE: This study evaluates the correlations amongst mandibular torus, palatine torus, oral exostoses to dental wear/loss and temporomandibular damage. METHODS: The sample consists of 504 skulls from the Hamann-Todd Osteological Collection; 223 African American and 281 European Americans aged between 30 and 80 years. The sample was analyzed using Pearson's Chi-square for significance of sex, age, ancestry, and wear as well as the interactions between the demographic variables and the presence of mandibular torus, palatine torus and oral exostoses. RESULTS: Wear was statistically significant by age and sex but not ancestry. The maxillary exostoses varied significantly by age, ancestry and wear but not sex. Mandibular torus frequencies varied significantly by wear, sex and ancestry. The palatine torus varied significantly across wear groups, sex and ancestry. DISCUSSION: The etiology of nonmetric oral cavity characteristics, mandibular torus, palatine torus and oral exostosis, is complex. The degree to which traits' presence and expression is the result of genetic and environmental interactions is not fully understood. More than age, sex or ancestry, the degree of dental wear and tooth loss influences the presence and expression of the oral cavity traits. The sample can be characterized as the presence of exostoses in higher frequencies in young African American males with little tooth loss. Males of both ancestral groups with heavy wear have higher frequencies of mandibular tori than females. The palatine torus is more common in edentulous European American females.


Assuntos
Exostose/patologia , Mandíbula/anormalidades , Mandíbula/patologia , Boca/patologia , Palato Duro/anormalidades , Palato/patologia , Desgaste dos Dentes/patologia , Adulto , Idoso , Exostose/etiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Ohio , Palato Duro/patologia , Desgaste dos Dentes/etiologia , Estados Unidos
15.
Head Neck Pathol ; 15(3): 1023-1030, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-33089457

RESUMO

Carney complex (CNC) is a rare, autosomal dominant multiple neoplasia syndrome. Although cutaneous myxomas commonly occur in CNC patients, intraoral myxomas are extremely rare. We present a case of a palatal myxoma in a 21-year-old female patient with CNC, along with a review of the pertinent literature. She presented with a sessile nodule on the hard palate that microscopically showed a multilobulated and highly vascularized myxomatous tissue composed of loosely-arranged spindle, polygonal, and stellate cells, suggestive of myxoid neurofibroma. Six years after the oral lesion was removed, she presented with a growth hormone (GH)-producing pituitary adenoma, a cardiac myxoma, two cutaneous myxomas on the lower abdomen area, and one myxoma in the vaginal mucosa. Therefore, the final diagnosis of the palatal lesion was of a soft tissue myxoma related to CNC. The patient remains on close follow-up, with no recurrences of the palatal myxoma after 7 years.


Assuntos
Complexo de Carney/patologia , Mixoma/genética , Neoplasias Palatinas/genética , Palato Duro/patologia , Feminino , Humanos , Mixoma/patologia , Neoplasias Palatinas/patologia , Adulto Jovem
16.
Autops. Case Rep ; 11: e2021244, 2021. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1285422

RESUMO

Necrotizing sialometaplasia (NS) is a benign, self-limiting inflammatory entity that mainly affects the minor salivary glands located in the hard palate. Classically, NS is characterized as a nodule that evolves to a central ulcer. The most widely recognized triggering factor is an ischemic event. The diagnosis becomes a challenge in non-ulcerated NS cases which is essential to rule out the possibility of salivary gland tumors, especially the malignant ones. Here, we presented a case of a 32-year-old male patient with a 1-month complaint of a painful, slightly elevated erythematous area on the hard palate. Incisional biopsy was performed, and NS was diagnosed based on histopathological and immunohistochemical analyses. Clinicians should be aware of and consider NS as a differential diagnosis of minor salivary gland tumors, particularly when it presents as a non-ulcerated clinical aspect.


Assuntos
Humanos , Masculino , Adulto , Sialometaplasia Necrosante , Neoplasias das Glândulas Salivares/patologia , Palato Duro/patologia , Diagnóstico Diferencial
17.
Plast Reconstr Surg ; 146(6): 1331-1339, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-33234964

RESUMO

BACKGROUND: For the cleft surgeon, palatal fistulae after cleft palate repair remain a difficult problem, with a paucity of local tissue options to aid closure. Small clinical series have described the use of the buccal fat pad flap to repair palatal fistulae; however, there is no literature detailing the anatomical coverage of the flap. This study delineates the anatomy of the buccal fat pad flap to guide surgeons in patient selection and examines the residual buccal fat after flap harvest to provide new information with regard to possible effects on the donor site. METHODS: Buccal fat pad flaps were raised in 30 hemicadavers. The reach of the flap across the midline, anteriorly and posteriorly, was recorded. In 18 hemicadavers, the entire buccal fat pad was then exposed to determine the effects of flap harvest on movement and volume of the residual fat. RESULTS: All buccal fat pad flaps provided coverage from the soft palate to the posterior third of the hard palate and all across the midline. Approximately three-fourths of flaps would cover the mid hard palate. The flap constitutes 36 percent of the total buccal fat pad on average, and a series of retaining ligaments were identified that may prevent overresection. CONCLUSIONS: The buccal fat pad flap is a useful tool for coverage of fistulae in the soft palate to the posterior third of the hard palate. In most cases, it will also reach the middle third; however, it is not suitable for more anterior defects. On average, two-thirds of the buccal fat pad remains within the cheek after flap harvest, which may protect against unwanted alteration in aesthetics.


Assuntos
Bochecha/cirurgia , Fístula/cirurgia , Procedimentos Cirúrgicos Bucais/efeitos adversos , Coleta de Tecidos e Órgãos/efeitos adversos , Sítio Doador de Transplante/cirurgia , Tecido Adiposo/transplante , Cadáver , Bochecha/anatomia & histologia , Estética , Estudos de Viabilidade , Fístula/patologia , Humanos , Procedimentos Cirúrgicos Bucais/métodos , Palato Duro/patologia , Palato Duro/cirurgia , Palato Mole/patologia , Palato Mole/cirurgia , Seleção de Pacientes , Retalhos Cirúrgicos/efeitos adversos , Retalhos Cirúrgicos/transplante , Coleta de Tecidos e Órgãos/métodos , Sítio Doador de Transplante/anatomia & histologia
18.
Homo ; 71(4): 273-280, 2020 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-33146661

RESUMO

Objectives: Torus Palatinus (TP) is a bony projection located on the oral surface of the hard palate. The trait is typically benign, has an unknown etiology, and varies widely in phenotypic expression. Prior studies suggest differences in TP prevalence by sex and ancestry, but the reported rates vary, even within a single ancestral group. We assessed the prevalence of TP and its association with palatal shape in a large multi-ethnic cohort of normal individuals. Methodology: 1102 adults were included (625 with European ancestry, 377 with West African anscestry, and 100 with East Asian ancestry). 3D digital dental casts were obtained and rated. TP frequencies were compared between sexes and/or ethnicities using Chi-squared tests. Dental cast models were then landmarked, and canonical variates analysis was performed to test for shape differences between those with and without TP. Results: Females had a significantly higher rate of TP than males across all three ancestral groups (p≤0.004). In males, no significant differences were found among ethnicities. Ancestral differences in TP frequency were driven by females, with East Asians having the highest rate (34.69%), followed by Europeans (24.88%) and West Africans (15.22%). Shape differences were found only in Asians and Africans, indicated a shorter and wider palate in presence of TP. Conclusions: Ethnic differences in TP frequency were present only in females. Further, females have considerably higher rates of TP than males in each population tested. Further studies of TP at earlier time-points and in connection to other aspects of craniofacial growth may shed light on these sex and ethnic differences.


Assuntos
Arco Dental/patologia , Exostose/epidemiologia , Doenças da Boca/epidemiologia , Palato Duro/patologia , Adolescente , Adulto , Antropologia Física , Feminino , Humanos , Masculino , Prevalência , Grupos Raciais/estatística & dados numéricos , Adulto Jovem
19.
Sci Rep ; 10(1): 19074, 2020 11 05.
Artigo em Inglês | MEDLINE | ID: mdl-33154503

RESUMO

This observational study compared palatal rugae morphology in adolescent subjects with normal tooth number and tooth agenesis. Maxillary dental study casts were used to compare rugae number, length and shape. Each study group contained 60 subjects (30 females and 30 males) mean age 13.4 (SD, 1.55) in control and 13.56 (SD, 1.54) years in tooth agenesis groups (p = 0.576). Mean number of missing tooth units in the tooth agenesis group was 2.1. Mean number of primary rugae in the whole sample was 4.35 (SD, 0.98) on the right and 4.33 (SD, 0.92) on the left with no significant differences (p = 0.236 and p = 0.404, respectively). However, the number of secondary rugae on the left (p = 0.006) and fragmentary rugae on the right (p = 0.004) was significantly increased in the tooth agenesis group. The shape of left primary rugae 2 and 3 also differed between groups, tending towards a wavy pattern in the control group and curved in the tooth agenesis group (p = 0.012 and p = 0.004, respectively). In addition, primary rugae 3 was more convergent (p = 0.008) whilst left primary rugae 3 and 5 were orientated in an antero-posterior direction (p = 0.04 for both rugae) in the tooth agenesis group. Subgroup analysis also identified significant associations between patterns of tooth agenesis and rugae number, in addition to shape of primary rugae. The identification of significant differences in rugae pattern between subjects with normal tooth number and agenesis suggests potential commonality in signal pathway disruption during establishment of these structures.


Assuntos
Anodontia/patologia , Palato Duro/anatomia & histologia , Palato Duro/patologia , Adolescente , Criança , Estudos de Coortes , Técnica de Fundição Odontológica , Feminino , Humanos , Masculino , Modelos Dentários
20.
Clin Nucl Med ; 45(10): 811-812, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32804762

RESUMO

Langerhans cell histiocytosis (LCH) is rare in adults. Oral and maxillofacial LCH commonly affects the bones of the skull and jaws. Here we report a case of a 57-year-old man with a painless oral mass evaluated by F-FDG PET/CT. PET/CT showed a solitary F-FDG-avid tumor in his left hard palate. LCH was confirmed after surgery. This case reminds us that LCH should be considered in an adult with hypermetabolic hard palate lesion on F-FDG PET/CT.


Assuntos
Histiocitose de Células de Langerhans/diagnóstico por imagem , Palato Duro/diagnóstico por imagem , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Fluordesoxiglucose F18 , Histiocitose de Células de Langerhans/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Palato Duro/patologia
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