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1.
Tokai J Exp Clin Med ; 45(3): 121-125, 2020 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-32901899

RESUMO

Clear cell carcinoma is an extremely rare low-grade malignancies occurring in less than 1% of salivary gland tumors. We report a case of clear cell carcinoma of the hard palate in a 15-year-old adolescent patient. She first noticed a palatal tumor at age 9, but the tumor was left untreated for 6 years. We performed incisional biopsy, but no definitive diagnosis was obtained. Excisional biopsy was then performed, and the histopathological diagnosis was clear cell carcinoma of the salivary gland. However, the tumor was exposed at the margin of the surgical specimen; thus, additional excision was performed. Five years after the treatment, no local recurrence or metastasis has been observed.


Assuntos
Carcinoma/diagnóstico , Carcinoma/patologia , Palato , Neoplasias das Glândulas Salivares/diagnóstico , Neoplasias das Glândulas Salivares/patologia , Adolescente , Biópsia , Feminino , Humanos , Margens de Excisão , Palato/patologia , Doenças Raras , Resultado do Tratamento
3.
J Oral Pathol Med ; 49(5): 443-449, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32133698

RESUMO

BACKGROUND: Reports of oral manifestations of granulomatosis with polyangiitis (GPA) usually refer to single-case reports; "strawberry gingivitis" has been increasingly reported. OBJECTIVE: To study the clinicopathological findings of four patients in which the diagnosis of GPA was suspected from the observation of their oral lesions and compare these to existent data. METHODS: Retrospective study of a case series. RESULTS: One patient presented typical "strawberry gingivitis" with localized disease and negative ANCA results. Two patients presented rapidly growing oral ulcers associated with systemic compromise and high ANCA levels. One patient presented with a chronic granulomatous lesion that leaded to palatal perforation. CONCLUSION: Oral manifestations of GPA may vary from rapidly evolving lesions in acutely ill patients to chronic and locally destructive lesions in slowing developing disease. These differences are also evident in the histopathological findings.


Assuntos
Gengivite/patologia , Granulomatose com Poliangiite/patologia , Palato/patologia , Anticorpos Anticitoplasma de Neutrófilos/sangue , Gengivite/etiologia , Granulomatose com Poliangiite/complicações , Humanos , Estudos Retrospectivos
4.
BMC Oral Health ; 20(1): 55, 2020 02 17.
Artigo em Inglês | MEDLINE | ID: mdl-32066451

RESUMO

BACKGROUND: The aim of this study was to assess the difference of palatal morphology in different vertical patterns between skeletal Class I subjects and skeletal Class II subjects with retrusive mandible. METHODS: Seventy-six skeletal Class II subjects with retrusive mandible (38 females, 38 males) and 85 skeletal Class I subjects (45 females, 40 males) were collected retrospectively and divided into hyperdivergent, normodivergent and hypodivergent groups. CBCT images of these subjects were reoriented by Dolphin 3D Imaging software. Three-dimensional (3D) maxilla was segmented by ProPlan software before using Geomagic Studio software to reconstruct 3D palatal morphology. Deviation patterns on 3D colored map analysis was performed to compare the difference of 3D palatal morphology between different groups. RESULTS: 3D colored map analysis showed that male's palate was higher and wider than that of female in the posterior part, regardless of different sagittal and vertical patterns. In skeletal Class II subjects with retrusive mandible, males with hyperdivergent and normodivergent showed higher and narrower in the posterior part of palate, while females with hyperdivergent and normodivergent had a higher but no obviously narrow palate compared with the hypodivergent subjects. Skeletal Class II subjects with retrusive mandible showed flatter and narrower in the posterior part of palate than that of skeletal Class I subjects. CONCLUSIONS: Sagittal and vertical patterns have great influence on the palatal morphology and as the vertical dimension increased, the palate tended to be higher and narrower.


Assuntos
Cefalometria/métodos , Imageamento Tridimensional/métodos , Má Oclusão de Angle Classe II/patologia , Mandíbula/anatomia & histologia , Maxila/anatomia & histologia , Palato/patologia , Dimensão Vertical , Adolescente , Adulto , Feminino , Humanos , Masculino , Má Oclusão de Angle Classe II/diagnóstico por imagem , Maxila/diagnóstico por imagem , Maxila/patologia , Radiografia Dentária Digital/métodos , Estudos Retrospectivos , Adulto Jovem
5.
J Invest Surg ; 33(1): 49-58, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29856665

RESUMO

Aim: The aim of this study was to evaluate the effect of Hypericum perforatum (HP) oil on wound-healing process in rabbit palatal mucosa. Materials and Methods: Thirty-six New Zealand albino rabbits were randomly allocated to following groups; (1) HP oil (test, n = 18) and (2) olive oil (control, n = 18). Palatinal excisional wounds were created and the oils were topically applied (0.1 ml, 30 s, twice a day). Gingival biopsies were excised, and analyzed for re-epithelialization (RE) and granulation tissue maturation (GTM) on days 3, 7, and 14 after surgery. Levels of vascular endothelial growth factor (VEGF) and fibroblast growth factor 2 (FGF-2) were assessed using the immunohistochemical method. Apoptotic cells (ACs) were evaluated using TUNEL staining. Enzyme-linked immunosorbent assay was used to assess tissue catalase (CAT) and malondialdehyde (MDA) levels. Results: RE and GTM were completed earlier in the HP oil group than in the control group. The number of positively stained cells/vessels was higher in olive oil than in the test group on day 3 for FGF-2 and on days 3 and 7 for VEGF (p < 0.05). In contrast, on day 14, a higher number of vessels was observed in the HP oil group than in the control group. HP oil treatment reduced the number of ACs compared to olive oil (p < 0.05), but the difference during the healing period did not reach significance. Tissue CAT and MDA levels between groups were not different, and also the results were the same when the levels were analyzed by the evaluated time periods (p > 0.05). Conclusions: The results of this study demonstrated that topical HP oil treatment did not provide an additional benefit to its base, olive oil, in the early phase of secondary wound healing.


Assuntos
Hypericum/química , Mucosa Bucal/efeitos dos fármacos , Óleos Vegetais/administração & dosagem , Reepitelização/efeitos dos fármacos , Ferida Cirúrgica/tratamento farmacológico , Administração Tópica , Animais , Biópsia , Modelos Animais de Doenças , Gengiva/efeitos dos fármacos , Gengiva/patologia , Gengiva/cirurgia , Humanos , Masculino , Mucosa Bucal/cirurgia , Palato/efeitos dos fármacos , Palato/patologia , Palato/cirurgia , Coelhos
6.
An Bras Dermatol ; 94(4): 449-451, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31644619

RESUMO

Benign migratory glossitis or geographic tongue is a benign condition that usually manifests as asymptomatic erythematous and migratory circinate patches, involving the lateral and dorsal aspects of the tongue. Extra-lingual lesions uncommonly occur and are mainly located on labial and buccal mucosae, lips and floor of the mouth. The present report describes one patient with a geographic lesion on the hard palate associated with lingual lesions and another patient who had multiple geographic lesions both in the hard and soft palate without lingual lesions. We found 64 cases in the English literature of ectopic locations with 22 palate involvement. No case of simultaneous involvement of the hard and the soft palate was found.


Assuntos
Glossite Migratória Benigna/patologia , Palato/patologia , Estomatite/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Mucosa Bucal/patologia , Língua/patologia
8.
J Bras Pneumol ; 45(4): e20180264, 2019 Aug 15.
Artigo em Inglês, Português | MEDLINE | ID: mdl-31432889

RESUMO

OBJECTIVE: To determine whether airway narrowing during obstructive events occurs predominantly at the retropalatal level and results from dynamic changes in the lateral pharyngeal walls and in tongue position. METHODS: We evaluated 11 patients with severe obstructive sleep apnea (OSA) and 7 healthy controls without OSA during wakefulness and during natural sleep (documented by full polysomnography). Using fast multidetector CT, we obtained images of the upper airway in the waking and sleep states. RESULTS: Upper airway narrowing during sleep was significantly greater at the retropalatal level than at the retroglossal level in the OSA group (p < 0.001) and in the control group (p < 0.05). The retropalatal airway volume was smaller in the OSA group than in the control group during wakefulness (p < 0.05) and decreased significantly from wakefulness to sleep only among the OSA group subjects. Retropalatal pharyngeal narrowing was attributed to reductions in the anteroposterior diameter (p = 0.001) and lateral diameter (p = 0.006), which correlated with an increase in lateral pharyngeal wall volume (p = 0.001) and posterior displacement of the tongue (p = 0.001), respectively. Retroglossal pharyngeal narrowing during sleep did not occur in the OSA group subjects. CONCLUSIONS: In patients with OSA, upper airway narrowing during sleep occurs predominantly at the retropalatal level, affecting the anteroposterior and lateral dimensions, being associated with lateral pharyngeal wall enlargement and posterior tongue displacement.


Assuntos
Tomografia Computadorizada Multidetectores/métodos , Doenças Faríngeas/diagnóstico por imagem , Doenças Respiratórias/diagnóstico por imagem , Apneia Obstrutiva do Sono/diagnóstico por imagem , Língua/diagnóstico por imagem , Adulto , Idoso , Estudos de Casos e Controles , Humanos , Masculino , Pessoa de Meia-Idade , Palato/diagnóstico por imagem , Palato/patologia , Palato/fisiopatologia , Doenças Faríngeas/patologia , Doenças Faríngeas/fisiopatologia , Faringe/diagnóstico por imagem , Faringe/patologia , Faringe/fisiopatologia , Polissonografia , Valores de Referência , Doenças Respiratórias/patologia , Doenças Respiratórias/fisiopatologia , Apneia Obstrutiva do Sono/patologia , Apneia Obstrutiva do Sono/fisiopatologia , Língua/patologia , Língua/fisiopatologia , Vigília/fisiologia
9.
An. bras. dermatol ; 94(4): 449-451, July-Aug. 2019. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1038316

RESUMO

Abstract: Benign migratory glossitis or geographic tongue is a benign condition that usually manifests as asymptomatic erythematous and migratory circinate patches, involving the lateral and dorsal aspects of the tongue. Extra-lingual lesions uncommonly occur and are mainly located on labial and buccal mucosae, lips and floor of the mouth. The present report describes one patient with a geographic lesion on the hard palate associated with lingual lesions and another patient who had multiple geographic lesions both in the hard and soft palate without lingual lesions. We found 64 cases in the English literature of ectopic locations with 22 palate involvement. No case of simultaneous involvement of the hard and the soft palate was found.


Assuntos
Humanos , Masculino , Feminino , Palato/patologia , Estomatite/patologia , Glossite Migratória Benigna/patologia , Língua/patologia , Pessoa de Meia-Idade , Mucosa Bucal/patologia
12.
BMC Med Genomics ; 12(1): 93, 2019 07 01.
Artigo em Inglês | MEDLINE | ID: mdl-31262291

RESUMO

BACKGROUND: Cleft palate (CP) is the second most common congenital birth defect; however, the relationship between CP-associated genes and epigenetic regulation remains largely unknown. In this study, we investigated the contribution of microRNAs (miRNAs) to cell proliferation and regulation of genes involved in CP development. METHODS: In order to identify all genes for which mutations or association/linkage have been found in individuals with CP, we conducted a systematic literature search, followed by bioinformatics analyses for these genes. We validated the bioinformatics results experimentally by conducting cell proliferation assays and miRNA-gene regulatory analyses in cultured human palatal mesenchymal cells treated with each miRNA mimic. RESULTS: We identified 131 CP-associated genes in the systematic review. The bioinformatics analysis indicated that the CP genes were associated with signaling pathways, microRNAs (miRNAs), metabolic pathways, and cell proliferation. A total 17 miRNAs were recognized as potential modifiers of human CP genes. To validate miRNA function in cell proliferation, a main cause of CP, we conducted cell proliferation/viability assays for the top 11 candidate miRNAs from our bioinformatics analysis. Overexpression of miR-133b, miR-374a-5p, and miR-4680-3p resulted in a more than 30% reduction in cell proliferation activity in human palatal mesenchymal cell cultures. We found that several downstream target CP genes predicted by the bioinformatics analyses were significantly downregulated through induction of these miRNAs (FGFR1, GCH1, PAX7, SMC2, and SUMO1 by miR-133b; ARNT, BMP2, CRISPLD1, FGFR2, JARID2, MSX1, NOG, RHPN2, RUNX2, WNT5A and ZNF236 by miR-374a-5p; and ERBB2, JADE1, MTHFD1 and WNT5A by miR-4680-3p) in cultured cells. CONCLUSIONS: Our results indicate that miR-374a-5p, miR-4680-3p, and miR-133b regulate expression of genes that are involved in the etiology of human CP, providing insight into the association between CP-associated genes and potential targets of miRNAs in palate development.


Assuntos
Fissura Palatina/genética , Fissura Palatina/patologia , Regulação da Expressão Gênica/genética , MicroRNAs/genética , Palato/patologia , Proliferação de Células/genética , Células Cultivadas , Biologia Computacional , Epigênese Genética , Humanos , Palato/metabolismo
13.
Elife ; 82019 06 04.
Artigo em Inglês | MEDLINE | ID: mdl-31162046

RESUMO

Epithelial fusion underlies many vital organogenic processes during embryogenesis. Disruptions to these cause a significant number of human birth defects, including ocular coloboma. We provide robust spatial-temporal staging and unique anatomical detail of optic fissure closure (OFC) in the embryonic chick, including evidence for roles of apoptosis and epithelial remodelling. We performed complementary transcriptomic profiling and show that Netrin-1 (NTN1) is precisely expressed in the chick fissure margin during fusion but is immediately downregulated after fusion. We further provide a combination of protein localisation and phenotypic evidence in chick, humans, mice and zebrafish that Netrin-1 has an evolutionarily conserved and essential requirement for OFC, and is likely to have an important role in palate fusion. Our data suggest that NTN1 is a strong candidate locus for human coloboma and other multi-system developmental fusion defects, and show that chick OFC is a powerful model for epithelial fusion research.


Assuntos
Coloboma/genética , Evolução Molecular , Olho/crescimento & desenvolvimento , Netrina-1/genética , Animais , Apoptose/genética , Embrião de Galinha , Galinhas , Coloboma/patologia , Sequência Conservada/genética , Células Epiteliais/metabolismo , Olho/patologia , Perfilação da Expressão Gênica , Regulação da Expressão Gênica no Desenvolvimento/genética , Humanos , Camundongos , Palato/crescimento & desenvolvimento , Palato/patologia , Peixe-Zebra/genética , Peixe-Zebra/crescimento & desenvolvimento
14.
Dis Model Mech ; 12(6)2019 06 27.
Artigo em Inglês | MEDLINE | ID: mdl-31171577

RESUMO

Core binding factor ß (Cbfb) is a cofactor of the Runx family of transcription factors. Among these transcription factors, Runx1 is a prerequisite for anterior-specific palatal fusion. It was previously unclear, however, whether Cbfb served as a modulator or as an obligatory factor in the Runx signaling process that regulates palatogenesis. Here, we report that Cbfb is essential and indispensable in mouse anterior palatogenesis. Palatal fusion in Cbfb mutants is disrupted owing to failed disintegration of the fusing epithelium specifically at the anterior portion, as observed in Runx1 mutants. In these mutants, expression of TGFB3 is disrupted in the area of failed palatal fusion, in which phosphorylation of Stat3 is also affected. TGFB3 protein has been shown to rescue palatal fusion in vitro TGFB3 also activated Stat3 phosphorylation. Strikingly, the anterior cleft palate in Cbfb mutants is further rescued by pharmaceutical application of folic acid, which activates suppressed Stat3 phosphorylation and Tgfb3 expression in vitro With these findings, we provide the first evidence that Cbfb is a prerequisite for anterior palatogenesis and acts as an obligatory cofactor in the Runx1/Cbfb-Stat3-Tgfb3 signaling axis. Furthermore, the rescue of the mutant cleft palate using folic acid might highlight potential therapeutic targets aimed at Stat3 modification for the prevention and pharmaceutical intervention of cleft palate.


Assuntos
Fissura Palatina/tratamento farmacológico , Fissura Palatina/patologia , Subunidade beta de Fator de Ligação ao Core/deficiência , Ácido Fólico/uso terapêutico , Animais , Fissura Palatina/genética , Subunidade beta de Fator de Ligação ao Core/metabolismo , Epitélio/efeitos dos fármacos , Epitélio/patologia , Ácido Fólico/farmacologia , Regulação da Expressão Gênica no Desenvolvimento/efeitos dos fármacos , Camundongos , Camundongos Mutantes , Modelos Biológicos , Mutação/genética , Organogênese/efeitos dos fármacos , Palato/anormalidades , Palato/embriologia , Palato/patologia , Fenótipo , RNA Mensageiro/genética , RNA Mensageiro/metabolismo , Fator de Transcrição STAT3/metabolismo , Fator de Crescimento Transformador beta3/metabolismo
15.
Trop Doct ; 49(4): 303-306, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31156067

RESUMO

Diffuse cutaneous leishmaniasis is a rare chronic infectious disease, associated with Leishmania mexicana and L. amazonensis, presenting as multiple non-ulcerative painless nodules, with a tendency to relapse soon after treatment. We report a case of a 56-year-old Mexican woman exhibiting nodular lesions, plaques, crusts and scars involving the whole body. A solitary nodule was present at the junction between hard and soft palates. Diffuse cutaneous leishmaniasis is a disfiguring disease resulting in severe scarring if untreated.


Assuntos
Leishmania mexicana/fisiologia , Leishmaniose Tegumentar Difusa/complicações , Leishmaniose Tegumentar Difusa/diagnóstico , Doenças da Boca/etiologia , Doenças da Boca/parasitologia , Palato/patologia , Feminino , Humanos , Leishmaniose Tegumentar Difusa/parasitologia , Leishmaniose Tegumentar Difusa/patologia , México , Pessoa de Meia-Idade , Palato/parasitologia , Recidiva
16.
Anticancer Res ; 39(5): 2527-2533, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31092449

RESUMO

BACKGROUND/AIM: We evaluated survival rates in surgically-treated oral and oropharyngeal squamous cell carcinoma patients at our clinic, and determined whether survival differed by tumour locations. PATIENTS AND METHODS: In a retrospective study, tumour lesions in 1,486 patients were categorized into 6 groups according to tumour location. Patients' age, sex, tumour-node-metastasis classification, resection status, 5-year and disease-specific survival rates were statistically analysed between groups. RESULTS: A significantly inferior disease-specific and lower 5-year survival rates for tumours located at the base of the tongue and oropharynx, and maxilla, due to higher T-stage and incomplete resection status were shown. Cervical lymph node metastasis and distant metastatic spread were more frequently observed with base of the tongue and oropharynx lesions. CONCLUSION: Attentive inspection and precise clinical examinations of specific oral and oropharyngeal regions are crucial for early diagnosis and treatment. Oral and oropharyngeal tumour locations play important roles in disease prognosis.


Assuntos
Neoplasias Bucais/cirurgia , Neoplasias Orofaríngeas/cirurgia , Prognóstico , Carcinoma de Células Escamosas de Cabeça e Pescoço/cirurgia , Adulto , Idoso , Feminino , Humanos , Metástase Linfática/patologia , Masculino , Maxila/patologia , Pessoa de Meia-Idade , Soalho Bucal/patologia , Neoplasias Bucais/epidemiologia , Neoplasias Bucais/patologia , Estadiamento de Neoplasias , Procedimentos Cirúrgicos Bucais , Neoplasias Orofaríngeas/epidemiologia , Neoplasias Orofaríngeas/patologia , Palato/patologia , Carcinoma de Células Escamosas de Cabeça e Pescoço/epidemiologia , Carcinoma de Células Escamosas de Cabeça e Pescoço/patologia , Taxa de Sobrevida
17.
mSphere ; 4(2)2019 04 03.
Artigo em Inglês | MEDLINE | ID: mdl-30944214

RESUMO

Denture stomatitis (DS) is a condition characterized by inflammation of the oral mucosa in direct contact with dentures and affects a significant number of otherwise healthy denture wearers. Candida-associated DS is predominantly caused by Candida albicans, a dimorphic fungus that readily colonizes and forms biofilms on denture materials. Previous studies showed a requirement for Candida biofilm formation on both palate and dentures in infection and identified fungal morphogenic transcription factors, Efg1 and Bcr1, as key players in DS pathogenesis. While both C. albicans and Candida glabrata are frequently coisolated in mucosal candidiasis, a pathogenic role for C. glabrata in DS remains unknown. Using an established rat model of DS, we sought to determine whether C. glabrata alone or coinoculation with C. albicans establishes colonization and causes palatal tissue damage and inflammation. Rats fitted with custom dentures were inoculated with C. albicans and/or C. glabrata and monitored over a 4-week period for fungal burden (denture/palate), changes in body weight, and tissue damage via lactate dehydrogenase (LDH) release as well as palatal staining by hematoxylin and eosin (H&E) and immunohistochemistry for myeloperoxidase (MPO) as measures of inflammation. C. glabrata colonized the denture/palate similarly to C. albicans In contrast to C. albicans, colonization by C. glabrata resulted in minimal changes in body weight, palatal LDH release, and MPO expression. Coinoculation with both species had no obvious modulation of C. albicans-mediated pathogenic effects. These data suggest that C. glabrata readily establishes colonization on denture and palate but has no apparent role for inducing/enhancing C. albicans pathogenesis in DS.IMPORTANCE Many denture wearers suffer from Candida-associated denture stomatitis (DS), a fungal infection of the hard palate in contact with dentures. Biofilm formation by Candida albicans on denture/palate surfaces is considered a central process in the infection onset. Although Candida glabrata is frequently coisolated with C. albicans, its role in DS pathogenesis is unknown. We show here, using a contemporary rat model that employed a patented intraoral denture system, that C. glabrata established stable colonization on the denture/palate. However, in contrast to C. albicans inoculated rats, rats inoculated with C. glabrata exhibited minimal changes in weight gain or palatal tissue damage. Likewise, coinoculation with the two Candida species resulted in no exacerbation of C. albicans-induced DS pathology. Together, our findings indicate that C. glabrata has no inducing/enhancing role in DS pathogenesis.


Assuntos
Candida glabrata/fisiologia , Dentaduras/microbiologia , Palato/microbiologia , Estomatite sob Prótese/microbiologia , Estomatite sob Prótese/patologia , Animais , Biofilmes , Candida albicans/genética , Candida albicans/isolamento & purificação , Candida glabrata/patogenicidade , Dentaduras/efeitos adversos , Modelos Animais de Doenças , Inflamação , L-Lactato Desidrogenase/metabolismo , Masculino , Mucosa Bucal/microbiologia , Mucosa Bucal/patologia , Palato/patologia , Peroxidase/análise , Ratos
19.
BMJ Case Rep ; 12(2)2019 Feb 09.
Artigo em Inglês | MEDLINE | ID: mdl-30739092

RESUMO

A multitude of disease processes ranging from periodontitis to malignancies can lead to formation of solitary ulcer on the palate. Hence solitary ulcers of palate can often be a challenging one to diagnose. We report an interesting case of a diffuse large B cell lymphoma of the maxillary sinus which perforated the palatal bone and presented clinically as a palatal ulcer. Initially the lesion manifested as a small ill-defined swelling in the posterior palatal slope in relation to 24and25 which were mobile and hence was erroneously diagnosed as chronic periodontal abscess. This paper is intended to stress the relevance of including non-Hodgkin's lymphoma in the differential diagnosis of solitary palatal ulcers as it may be often misdiagnosed as more common reactive or inflammatory lesions.


Assuntos
Linfoma Difuso de Grandes Células B/patologia , Neoplasias do Seio Maxilar/patologia , Úlceras Orais/patologia , Palato/patologia , Adulto , Tomografia Computadorizada de Feixe Cônico , Feminino , Humanos , Linfoma Difuso de Grandes Células B/complicações , Linfoma Difuso de Grandes Células B/diagnóstico por imagem , Neoplasias do Seio Maxilar/complicações , Neoplasias do Seio Maxilar/diagnóstico por imagem , Úlceras Orais/etiologia
20.
J R Army Med Corps ; 165(6): 454, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30610088

RESUMO

A case of panfacial trauma is reported comprising of multiple facial fractures and a clearly evident Guerin's sign along with an oronasal communication. The case reinforces the importance of recognising this sign and its classical presentation.


Assuntos
Traumatismos Faciais , Palato , Fraturas Cranianas , Acidentes de Trânsito , Humanos , Masculino , Palato/lesões , Palato/patologia
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