Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 10.204
Filtrar
1.
Klin Lab Diagn ; 64(8): 481-483, 2019.
Artigo em Russo | MEDLINE | ID: mdl-31479603

RESUMO

A case of benign proliferative formation of the mammary gland of a rare histological form - subareolar sclerosing ductal hyperplasia in combination with papillomatosis of the nipple is presented. Pathology belongs to the group of complex sclerosing lesions. When setting the morphological (cytological, histological) diagnosis, it is necessary to take into account the clinical picture - the state of the nipple-areola complex, in particular, the presence / absence of nipple discharge and its involvement in the pathological process.


Assuntos
Glândulas Mamárias Humanas/patologia , Mamilos/patologia , Papiloma/patologia , Humanos , Hiperplasia
2.
Ocotal, Nueva Segovia; s.n; mayo 2019. 68 p. ilus, tab, graf, mapas.
Tese em Espanhol | LILACS | ID: biblio-1015426

RESUMO

OBJETIVO: Determinar el cumplimiento del esquema de vacunación contra el Virus de Papiloma Humano en niñas de 11 años, Municipio de Danlí, Departamento El Paraíso, Honduras, 2018. DISEÑO: Estudio Descriptivo de corte Transversal, universo de estudio fue la totalidad de 2,216 dosis aplicadas de los registros vacunales de VPH del PAI, de niñas de 11 años. RESULTADOS: En el municipio de Danlí, departamento de El Paraíso, se encontraron bajas coberturas para las segundas dosis de VPH en las de niñas de 11 años, predominando en un 69% de los establecimientos de salud. En el mes de diciembre se captaron mayor número de este grupo de población para completar su esquema de dos dosis (114%), hubo una brecha menor o igual al 5% de cumplimiento en un 35% de los establecimientos y un período de cumplimiento entre las dosis de 6 meses en un 72%. CONCLUSIONES: El nivel de riesgo fue alto, tanto para primeras como para segundas dosis aplicadas de VPH y el nivel de riesgo alto predominó en la mayoría de establecimientos de salud para ambas dosis pero habiendo aumentado en la aplicación de la segunda dosis, el índice de cobertura de inmunización alcanzado fue en aumento a medida que se avanzaba en los meses habiendo alcanzado el mayor porcentaje superando el cumplimiento en el mes de diciembre, en relación a los meses anteriores. La brecha de cobertura de inmunización por establecimiento estuvo concentrada por debajo de la mitad. El período de cumplimiento entre primeras y segundad dosis se dio su mayoría en 6 meses seguido por 7 meses y solo un menor porcentaje en mas de 7 meses


Assuntos
Humanos , Papiloma , Papillomaviridae , Programas de Imunização , Infecções por Papillomavirus , Saúde Pública , Epidemiologia Descritiva , Estudos Transversais
4.
Zhonghua Yan Ke Za Zhi ; 55(5): 369-373, 2019 May 11.
Artigo em Chinês | MEDLINE | ID: mdl-31137149

RESUMO

Objective: To summarize and analyze the clinical manifestation of conjunctival papilloma, its relationship with human papillomavirus (HPV) infection and the recurrence after the combination of operation and pharmacotherapy. Methods: A retrospective case series study. Analysis of 40 patients (41 eyes) with conjunctival papilloma treated at Peking Union Medical College Hospital from January 2008 to June 2018 was performed. All patients were given routine blood and urine, hepatitis B virus surface antigen, antibodies to hepatitis C virus, antibodies to human immunodeficiency virus and antibodies to Treponema pallidum testing, and HPV testing for the urethra epithelial tissue. Direct contact of the tumor with instruments was avoided during surgery, and freezing treatment was combined. HPV testing was performed for the resected conjunctival papilloma. Multiple medications were used after surgery. Results: In 40 cases with 41 eyes, there were 22 males (23 eyes) and 18 females (18 eyes). A single tumor was seen in 27 eyes, and multiple tumors were seen in 14 eyes. Thirteen patients (13 eyes) older than 50 years old had pedicel-free papillpma, and 27 patients (28 eyes) aged from 12 to 40 years had pedicel-type papillpma. All cases were confirmed by pathology as conjunctival papilloma, of which 9 cases showed moderate to severe atypical hyperplasia on squamous cells. The HPV test was positive in 17 out of the 40 cases (42.5%) of conjunctival papilloma. Urine test results of 16 patients (40.0%) were positive for occult blood and showed that urinary white blood cell was elevated. Of the 40 patients, 33 were newly diagnosed and 7 had a relapse. The average follow-up time was (37.4±11.9) months after combined therapy and no recurrence was found in any patients. Conclusions: Conjunctival papilloma is usually observed in people aged from 20 to 40 years and older than 50 years, and it often occurs in one eye. Its main pathological feature is benign tumors of the papillary hyperplasia on the conjunctival epithelial tissue. Some patients have atypical hyperplasia of squamous cells. The cause of the disease may be related to the infection of HPV and the urinary tract. Combined treatment can reduce the recurrence rate of conjunctival papilloma. (Chin J Ophthalmol, 2019, 55: 369-373).


Assuntos
Carcinoma de Células Escamosas/diagnóstico , Túnica Conjuntiva/patologia , Neoplasias da Túnica Conjuntiva/diagnóstico , Papiloma/patologia , Adolescente , Adulto , Carcinoma de Células Escamosas/virologia , Criança , Neoplasias da Túnica Conjuntiva/virologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Papiloma/virologia , Papillomaviridae/isolamento & purificação , Infecções por Papillomavirus/diagnóstico , Infecções por Papillomavirus/virologia , Estudos Retrospectivos , Adulto Jovem
5.
Einstein (Sao Paulo) ; 17(2): eRC4624, 2019 May 09.
Artigo em Inglês, Português | MEDLINE | ID: mdl-31090794

RESUMO

Oral squamous papilloma is a benign tumor whose pathogenesis has been associated with human papillomavirus infection. Thus, it is noteworthy that human papillomavirus infection is one of the risk factors associated with the development of cervical, anogenital, pharynx, larynx and oral cavity carcinomas. Oral squamous papilloma can affect any region of the oral cavity, and transmission of human papillomavirus can occur by direct contact, sexual intercourse or from mother to child during delivery. The diagnosis is clinical and histopathological, with surgical removal representing the treatment of choice. Recently, widefield optical fluorescence has been used as a complementary examination to the conventional clinical examination in the screening of oral pathological lesions and for the delimitation of surgical margins. We report a case of oral squamous papilloma with its clinical, histopathological features and, in addition, from the perspective of wide field optical fluorescence.


Assuntos
Neoplasias Bucais/diagnóstico , Neoplasias de Células Escamosas/diagnóstico , Papiloma/diagnóstico , Fluorescência , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Bucais/patologia , Neoplasias de Células Escamosas/patologia , Palato Duro , Papiloma/patologia
6.
Clin Ter ; 170(2): e84-e85, 2019 Mar-Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30993301

RESUMO

INTRODUCTION: Human papillomaviruses cause almost all cervical carcinomas, but HPV infections have recently been established as a major etiologic factor for a subset of cancers arising from the oropharinx, including the base of tongue, tonsil, and other parts of the pharinx. Certain types of HPV are considered carcinogenic in humans: HPV 16 and HPV 18 are the most carcinogenic types; HPV 31, 33, 35,39,45,51,52,56,59,66 and 68 also are included in the group of carcinogenic HPV types (1,2,3,4,5). HPV 6 and 11 are associated with genital warts and papillomas are not believed to be carcinogenic (6). The aim of this paper is to show a case of a benignant papilloma of the nasal fossa due to a HPV 11 infection.


Assuntos
Papillomavirus Humano 11/isolamento & purificação , Papiloma/diagnóstico , Infecções por Papillomavirus/diagnóstico , Adulto , Humanos , Masculino
7.
Arch Virol ; 164(5): 1441-1444, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30847608

RESUMO

To date, there have been no reports of coinfection with bovine papular stomatitis virus (BPSV) and bovine papillomavirus (BPV) in the same lesion. In the present study, one lingual papilloma-like sample was collected at an abattoir from the tongue of a 31-month-old Japanese black cow. Coinfection with BPSV and BPV was confirmed by histopathology, immunohistochemistry, PCR and RT-PCR. The evidence for coinfection with BPSV and BPV in the same lesion and an association of BPV with lingual papillomatosis will contribute to future epidemiological studies of these two viruses.


Assuntos
Papillomavirus Bovino 1/isolamento & purificação , Coinfecção/veterinária , Infecções por Papillomavirus/complicações , Parapoxvirus/isolamento & purificação , Infecções por Poxviridae/complicações , Doenças da Língua/virologia , Animais , Bovinos , Coinfecção/virologia , Papiloma/veterinária , Papiloma/virologia , Infecções por Papillomavirus/veterinária , Infecções por Papillomavirus/virologia , Infecções por Poxviridae/veterinária , Infecções por Poxviridae/virologia , Língua/virologia , Doenças da Língua/veterinária
8.
Eur Arch Otorhinolaryngol ; 276(3): 793-800, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30798335

RESUMO

PURPOSE: Recurrent respiratory papillomatosis is a disease caused by the human papilloma virus (HPV). HPV is frequently localised in the larynx. The disease tends to recur and frequent intervention is usually required. Management modules include surgical intervention using microdebriders or laser ablation as well as adjuvant treatments which aim mainly at maintaining an adequate airway and secondly to manage dysphonia caused by the growth on the vocal folds. In this pilot study, another surgical modality is trialled using plasma-mediated radio-frequency ablation (coblation). METHODS: Retrospective study examining management of 15 adult patients diagnosed with recurrent laryngeal papillomatosis and surgically treated using coblation. One patient required multiple procedures. Pre-operative assessment in voice clinic evaluating voice quality and its impact on patients' life-quality using voice parameters and self-assessment questionnaires. Follow-up post-operatively using the same parameters from 4 to 6 weeks after surgery until up to 2 years later to check recurrence rate. No other adjuvant treatment was used and all patients received post-operative voice therapy. RESULTS: 78.6% of patients did not show evidence of recurrence during the study period. Improvement in voice handicap following first intervention is reported and recurrence rate in the rest of the sample reported. CONCLUSIONS: The results of this small sample seem to support the previous small studies' findings that coblation is a good excisional technique to use for removal of laryngeal papillomatosis. Recurrence rates seem to be slightly lower than rates reported in the literature for the other surgical modalities. LEVEL OF EVIDENCE: IV.


Assuntos
Ablação por Cateter/métodos , Neoplasias Laríngeas/cirurgia , Recidiva Local de Neoplasia/cirurgia , Papiloma/cirurgia , Adulto , Feminino , Humanos , Laringe , Terapia a Laser , Masculino , Pessoa de Meia-Idade , Papillomaviridae , Projetos Piloto , Estudos Retrospectivos
9.
Ann Surg Oncol ; 26(6): 1695-1703, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30737665

RESUMO

BACKGROUND: There is no consensus regarding the management of benign papillary breast lesions diagnosed on image-guided core needle biopsy (IGCNB). METHODS: This is a retrospective review of 407 patients within Kaiser Permanente Northern California diagnosed between 2012 and 2013. The study focused on patients presenting with a mass lesion and who were diagnosed with a benign papillary breast lesion (BPBL) on IGCNB. Patients who did not have surgical excision of the IGCNB papilloma were followed for at least 2 years. RESULTS: A total of 327 patients (80%) underwent surgical excision, 61 patients (15%) had follow-up imaging, and 19 patients (5%) had no surgery or imaging. Overall among women with surgical excision, 9.5% had a high-risk lesion, 3.4% had in situ cancer, and 2.4% had invasive cancer. An upgrade to an in situ cancer or invasive cancer was more common among women with a lesion greater than 1 cm, a palpable breast mass, age > 50 years, or if the lesion was > 5 cm from the nipple. No cancers were diagnosed in 61 women followed by imaging surveillance. CONCLUSIONS: This is the largest, single-cohort study of benign papillary mass lesions diagnosed on IGCNB. On surgical excision, the overall rate of upgrade to in situ cancer and invasive cancer was low, and almost all cancers diagnosed had favorable features. Because no cancers were found in women who were followed by imaging, we conclude that outcomes for BPBL diagnosed on IGCNB are favorable whether surgical excision or surveillance is the treatment choice.


Assuntos
Neoplasias da Mama/cirurgia , Carcinoma in Situ/cirurgia , Carcinoma Papilar/cirurgia , Biópsia Guiada por Imagem/métodos , Mastectomia/métodos , Papiloma/cirurgia , Ultrassonografia Mamária/métodos , Idoso , Neoplasias da Mama/diagnóstico por imagem , Neoplasias da Mama/patologia , Carcinoma in Situ/diagnóstico por imagem , Carcinoma in Situ/patologia , Carcinoma Papilar/diagnóstico por imagem , Carcinoma Papilar/patologia , Feminino , Seguimentos , Humanos , Pessoa de Meia-Idade , Papiloma/diagnóstico por imagem , Papiloma/patologia , Seleção de Pacientes , Estudos Retrospectivos , Resultado do Tratamento
10.
Artigo em Chinês | MEDLINE | ID: mdl-30808153

RESUMO

Recurrent respiratory papilloma (RRP) is closely related to human papillomavirus (HPV) infection and is the main pathogenic factor. At present, HPV vaccine injection is a new method to control RRP, and its efficacy has been confirmed by many clinical trials. The development and application of HPV vaccine is bound to bring new development to the treatment of RRP. This article reviews the status of HPV vaccine in clinical RRP treatment.


Assuntos
Papiloma , Infecções por Papillomavirus , Vacinas contra Papillomavirus , Infecções Respiratórias , Papillomavirus Humano 11 , Humanos , Infecções por Papillomavirus/prevenção & controle , Infecções por Papillomavirus/terapia , Vacinas contra Papillomavirus/uso terapêutico , Infecções Respiratórias/prevenção & controle , Infecções Respiratórias/terapia
11.
Pathol Int ; 69(2): 104-109, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30664316

RESUMO

Mixed squamous cell and glandular papilloma (mixed papilloma) is a very rare tumor, with fewer than 25 cases having been reported in the literature. Although a scattering of cases of p16Ink4a overexpression have been described to date, no human papillomavirus (HPV) DNA has been detected in these tumors, either by in situ hybridization (ISH) or polymerase chain reaction (PCR). This is the first case of mixed papilloma with PCR-confirmed HPV genotype 16, 35, 51 infections in an 18-year-old non-smoking male, coexisting with multiple atypical adenomatous hyperplasias (AAHs). Histologically, this tumor shows a predominant papillary architecture, covered by a mixture of stratified squamous cells, ciliated or non-ciliated cuboidal to columnar cells, mucous cells, and scattered goblet cells. Immunohistochemically, the squamous component was positive for p40, and the glandular cells were focally positive for TTF-1. Both components were diffusely immunoreactive to CK7. In addition, BRAF V600E mutation was also first demonstrated in mixed papilloma, but not in the AAHs. These findings suggest that HPV infection and the BRAF mutation may be important in the pathogenetic role in young non-smoking patients.


Assuntos
Carcinoma de Células Escamosas/patologia , Neoplasias Pulmonares/patologia , Papiloma/patologia , Infecções por Papillomavirus/complicações , Proteínas Proto-Oncogênicas B-raf/genética , Adolescente , Carcinoma de Células Escamosas/genética , Carcinoma de Células Escamosas/virologia , Humanos , Neoplasias Pulmonares/genética , Neoplasias Pulmonares/virologia , Masculino , Mutação , Papiloma/genética , Papiloma/virologia
12.
Curr Opin Otolaryngol Head Neck Surg ; 27(2): 85-90, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30694913

RESUMO

PURPOSE OF REVIEW: To gain the evidence-based knowledge concerning the efficacy of HPV vaccination for oropharyngeal sites and to highlight the trials and strategies for vaccine administration in HPV-dependent head and neck diseases. RECENT FINDINGS: Vaccination can be provided in two injections. There is increasing anecdotal evidence that therapeutic vaccination is effective in treatment of recurrent respiratory papillomatosis. SUMMARY: The availability and broadening spectrum of HPV vaccines make possible the prevention of cervical and other HPV-dependent diseases. Vaccination is now included in the national immunization programs of most industrial countries and will be used, it is hoped, in developing countries within the next few years. In developing countries, few women are screened for cervical precancerous lesions, making immunization even more important. In affluent countries and matured societies, with high coverage of cervical screening, the focus of interest will shift to other HPV-related diseases. The HPV vaccination is effective in preventing oral infection with types targeted by the vaccines.


Assuntos
Neoplasias de Cabeça e Pescoço/prevenção & controle , Neoplasias de Cabeça e Pescoço/virologia , Infecções por Papillomavirus/prevenção & controle , Vacinas contra Papillomavirus/uso terapêutico , Feminino , Humanos , Papiloma/prevenção & controle , Papiloma/virologia , Infecções por Papillomavirus/virologia , Lesões Pré-Cancerosas/prevenção & controle , Lesões Pré-Cancerosas/virologia , Neoplasias do Sistema Respiratório/prevenção & controle , Neoplasias do Sistema Respiratório/virologia
13.
BMJ Case Rep ; 11(1)2018 Dec 14.
Artigo em Inglês | MEDLINE | ID: mdl-30567257

RESUMO

Juvenile papillomatosis is a benign epithelial proliferative tumour of young women. It was recognised as a distinct clinicopathological entity with defining criteria by Rosen et al since 1980. However, giant juvenile papillomatosis is rare. We report a case of a 14-year-old girl who presented to our institution's breast clinic with a huge right breast mass measuring 20 cm × 15 cm. She had no personal history of previous breast disease and there was no family history of breast cancer. Our initial preoperative diagnosis was of a phylloides tumour. The patient had a total excision of her breast mass which revealed florid juvenile papillomatosis at histology. This presentation highlights the clinical presentation and imaging features of juvenile papillomatosis. The classical histopathological characteristics, unusual microscopic findings and management of a huge-sized tumour in an adolescent Nigerian patient are also presented.


Assuntos
Neoplasias da Mama/patologia , Mama/patologia , Neoplasias Epiteliais e Glandulares/patologia , Papiloma/patologia , Adolescente , Mama/diagnóstico por imagem , Neoplasias da Mama/diagnóstico por imagem , Neoplasias da Mama/cirurgia , Feminino , Humanos , Neoplasias Epiteliais e Glandulares/diagnóstico por imagem , Neoplasias Epiteliais e Glandulares/cirurgia , Papiloma/diagnóstico por imagem , Papiloma/cirurgia , Resultado do Tratamento , Ultrassonografia
14.
Pan Afr Med J ; 30: 209, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30574228

RESUMO

Introduction: Although Laryngeal papillomatosis is a rare disease and can be conventionally managed through surgical excision as well as adjuvant therapy yet Laryngeal papillomatosis has high tendency to recur raising its prevalence in the community, airway involvement warrants dangerous complications requiring emergency tracheostomy, especially if clinical course is poorly understood and misdiagnosis is common. The study aims to determine the prevalence, clinical features, risk factors and recurrence of Laryngeal Papillomatosis among patients attending ENT department at KCMC from 2005 to 2015. Methods: This was a 10 year experience/ Descriptive hospital based cross-sectional study conducted based on patients' medical record at KCMC. Information was recorded into data collection sheets, entered and analyzed through SPSS version 20, summarized and presented in tables and charts, proportions and percentage used to compare groups. Results: 51 patients were identified over the 10 years study period corresponding to a prevalence of 0.09%. 26 were males and 25 females, ages ranging from 1 to 67 years. The median age of onset was 6 years. Children less than 5 years accounted for 19 (37.3%) and 58.8% had repeated surgeries. Clinical presentation ranged from hoarseness in 43 (84.3%) patients to weight loss 3 (5.9%) and 96.1% showed complete or partial presence of the clinical triad of risk factors. Conclusion: Laryngeal papillomatosis is a rare disease that carries severe morbidity due to its highly recurring nature. It is primarily a paediatric disease, generally affecting more males; its clinical features highly resemble other airway obstructive diseases and therefore a careful thorough clinical evaluation is required in order to correctly diagnose Laryngeal papillomatosis.


Assuntos
Rouquidão/etiologia , Neoplasias Laríngeas/epidemiologia , Papiloma/epidemiologia , Perda de Peso , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Estudos Transversais , Feminino , Humanos , Lactente , Pacientes Internados , Neoplasias Laríngeas/diagnóstico , Neoplasias Laríngeas/etiologia , Masculino , Pessoa de Meia-Idade , Papiloma/diagnóstico , Papiloma/etiologia , Prevalência , Recidiva , Fatores de Risco , Tanzânia , Centros de Atenção Terciária , Adulto Jovem
15.
Niger J Clin Pract ; 21(12): 1674-1677, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30560835

RESUMO

Squamous papillomas are common lesions of the oral mucosa. They are benign proliferating lesions often painless, slow growing and with a cauliflower appearance. However, its clinical appearance which sometimes mimics exophytic carcinoma, verrucous carcinoma or condyloma acuminatum raises concern when it occurs in the oral cavity. Squamous papilloma occurs predominantly in 30- to 50-year old's. However, they may be seen in children <10 years and accounted for 8% of all oral tumors in children. There is no sex predilection. It has a predilection for the tongue and soft palate, but may occur on any other surface of the oral cavity. Oral squamous papillomas have been associated with infection by the human papilloma virus (HPV). The present report is a case of a recurrent squamous papilloma of the hard palate in a 5-year-old patient with a review of the literature.


Assuntos
Mucosa Bucal/patologia , Neoplasias Palatinas/patologia , Papiloma/patologia , Pré-Escolar , Feminino , Humanos , Masculino , Neoplasias Palatinas/cirurgia , Neoplasias Palatinas/virologia , Palato Mole/patologia , Papiloma/cirurgia , Papiloma/virologia , Papillomaviridae , Infecções por Papillomavirus/patologia , Recidiva
16.
World J Surg Oncol ; 16(1): 234, 2018 Dec 17.
Artigo em Inglês | MEDLINE | ID: mdl-30558621

RESUMO

BACKGROUND: Benign breast papilloma is currently managed with conservative management with close observation. In contrast, papilloma with high-risk or malignant lesions warrants surgical excision. The purpose of our study was to investigate magnetic resonance imaging (MRI) features of breast papilloma and to identify imaging diagnostic indicators for papilloma with high-risk or malignant lesions. METHODS: MRI features of 175 surgically confirmed papillomas on 158 patients were retrospectively reviewed. The 175 cases included 132 cases of benign papilloma and 43 cases of papilloma with high-risk or malignant lesions. The MRI features of these lesions were classified into three types: mass, non-mass enhancement (NME), and occult lesion. The occult lesion was defined as the presence of only ductal dilation without any enhanced lesions on MRI. For a mass lesion, the mixed mass-NME lesion was considered if linear, segmental or regional enhanced lesion was found adjacent to the mass. Clinical and MRI features were compared by univariate and multivariate analysis between the benign papilloma and the papilloma with high-risk or malignant lesions. RESULTS: Multivariate logistic regression analysis demonstrated that clinical characteristics including being or older than 50 years (odds ratio [OR] = 4.506), having bloody nipple discharge (OR = 4.499), and concurrent breast cancer (OR = 5.083) were significant indicators for papilloma with high-risk or malignant lesions. On MRI, most papillomas presented as mass (n = 135, 77.1%), and fewer as NME (n = 37, 21.1%) and occult lesion (n = 3, 1.7%). For the mass lesion, the logistic regression analysis demonstrated that a mass size exceeding 10 mm (OR = 2.956) and mixed mass-NME lesion (OR = 4.143) were independent risk indicators for a papilloma with high-risk or malignant lesions. For the NME lesion, the segmental or regional distribution was more commonly observed in the papilloma with high-risk or malignant lesions (61.5%) than the benign papilloma (12.5%) (P = 0.006). All the cases of occult lesions were benign papillomas. CONCLUSIONS: MRI features including a mass size exceeding 10 mm, mixed mass-NME lesion, and NMEs with segmental or regional distribution indicate a papilloma with high-risk or malignant lesions.


Assuntos
Neoplasias da Mama/diagnóstico por imagem , Papiloma/diagnóstico por imagem , Adulto , Fatores Etários , Idoso , Mama/diagnóstico por imagem , Mama/patologia , Neoplasias da Mama/patologia , Diagnóstico Diferencial , Feminino , Humanos , Imagem por Ressonância Magnética , Pessoa de Meia-Idade , Papiloma/patologia , Prognóstico , Estudos Retrospectivos
17.
Nat Commun ; 9(1): 5293, 2018 12 13.
Artigo em Inglês | MEDLINE | ID: mdl-30546048

RESUMO

We used allogeneic bone marrow transplantation (BMT) and a mouse multistage cutaneous carcinogenesis model to probe recruitment of bone marrow-derived epithelial cells (BMDECs) in skin tumors initiated with the carcinogen, dimethylbenz[a]anthracene (DMBA), and promoted with 12-O-tetradecanolyphorbol-13-acetate (TPA). BMDECs clustered in the lesional epithelium, expressed cytokeratins, proliferated, and stratified. We detected cytokeratin induction in plastic-adherent bone marrow cells (BMCs) cultured in the presence of filter-separated keratinocytes (KCs) and bone morphogenetic protein 5 (BMP5). Lineage-depleted BMCs migrated towards High Mobility Group Box 1 (HMGB1) protein and epidermal KCs in ex vivo invasion assays. Naive female mice receiving BMTs from DMBA-treated donors developed benign and malignant lesions after TPA promotion alone. We conclude that BMDECs contribute to the development of papillomas and dysplasia, demonstrating a systemic contribution to these lesions. Furthermore, carcinogen-exposed BMCs can initiate benign and malignant lesions upon tumor promotion. Ultimately, these findings may suggest targets for treatment of non-melanoma skin cancers.


Assuntos
Células da Medula Óssea/patologia , Transformação Celular Neoplásica/induzido quimicamente , Transformação Celular Neoplásica/patologia , Células Epiteliais/patologia , Neoplasias Cutâneas/patologia , 9,10-Dimetil-1,2-benzantraceno/toxicidade , Animais , Células da Medula Óssea/citologia , Transplante de Medula Óssea , Proteína Morfogenética Óssea 5/metabolismo , Movimento Celular , Plasticidade Celular/fisiologia , Técnicas de Cocultura , Células Epiteliais/citologia , Feminino , Proteína HMGB1/metabolismo , Folículo Piloso/citologia , Queratinócitos/patologia , Queratinas/metabolismo , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Invasividade Neoplásica/patologia , Papiloma/patologia , Células-Tronco/citologia , Células-Tronco/patologia , Acetato de Tetradecanoilforbol/toxicidade , Células Tumorais Cultivadas
19.
J Vet Med Sci ; 80(11): 1691-1695, 2018 Nov 09.
Artigo em Inglês | MEDLINE | ID: mdl-30210094

RESUMO

Severe papillomatosis occasionally causes astasia leading to euthanizing cattle. There are currently a limited number of reports on virologic approach in severe bovine papillomatosis. Here we report a full genome characterization of bovine papillomavirus type 1 (BPV-1) from the case of severe papillomatosis. A calf developed numerous papillomas on the skin and some nodules in the upper gastrointestinal tract at seven months old. The skin lesion was diagnosed as the epithelial papilloma with BPV antigen expression, while the gastrointestinal lesions were diagnosed as the fibropapilloma without BPV antigen. Full genome analysis revealed that BPV-1s detected in all the lesions were exactly the same. Compared with the reference BPV-1 sequence, there was a single nucleotide insertion in the upstream regulatory region.


Assuntos
Papillomavirus Bovino 1/genética , Genoma Viral , Papiloma/veterinária , Neoplasias Cutâneas/veterinária , Animais , Papillomavirus Bovino 1/isolamento & purificação , Bovinos , Doenças dos Bovinos , Masculino , Papiloma/virologia , Neoplasias Cutâneas/virologia
20.
Autops. Case Rep ; 8(3): e2018035, July-Sept. 2018. ilus
Artigo em Inglês | LILACS | ID: biblio-911896

RESUMO

Papilloma associated with recurrent respiratory papillomatosis (RRP), caused by human papilloma virus (HPV) infection types 6 and 11, is the most common benign neoplasm of the larynx. The clinical features of RRP vary widely from mild to aggressive forms. RRP in children is known as juvenile-onset recurrent respiratory papillomatosis (JORRP). Its outcome may be poor or even fatal due to the high rate of recurrence and eventual spread to the entire respiratory tract. Pulmonary invasion is reported to occur in 3.3% of patients with RRP, and malignant transformation in 0.5% of patients. We report the case of a 39-year-old female patient with a diagnosis of JORRP from the age of 3 years, with extensive bilateral pulmonary involvement and malignant transformation. Analysis of the papilloma and carcinomatous tissues revealed the presence of HPV type 11, which is associated with rapid and aggressive progression. We discussed the case on the basis of a literature review on pulmonary invasion, malignant transformation, and HPV 11 aggressiveness.


Assuntos
Humanos , Feminino , Adulto , Carcinoma de Células Escamosas/complicações , Neoplasias Pulmonares/complicações , Infecções por Papillomavirus/complicações , Autopsia , Carcinoma de Células Escamosas/patologia , Evolução Fatal , Papillomavirus Humano 11 , Papiloma/complicações
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA