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1.
Am J Surg Pathol ; 45(1): 119-126, 2021 01.
Artigo em Inglês | MEDLINE | ID: mdl-32868527

RESUMO

Glandular papilloma (GP) and mixed squamous cell and glandular papilloma (MP) are rare benign pulmonary tumors occurring in the bronchi. Bronchiolar adenoma (BA) was recently characterized as a pulmonary tumor exhibiting alveolar spread. Both GP/MP and BA are composed of a mixture of glandular, ciliated, squamous, and basal cells. We aimed to clarify whether GP/MP and BA represent the same tumor. We evaluated the detailed histologic characteristics of 11 cases involving pulmonary peripheral tumors that exhibited histologic features of GP/MP or BA, and performed genetic analyses using targeted panel sequencing, allele-specific polymerase chain reaction, and digital polymerase chain reaction. Histologically, 4 and 7 tumors were classified as GP/MP and BA, respectively. GP/MP showed endobronchiolar papillary growth with a pseudostratified or stratified epithelium. In contrast, 5 BAs showed a predominant flat structure with a bilayered or pseudostratified epithelium, whereas 2 BAs showed a GP/MP-like papillary architecture. The mean epithelial thickness in each tumor was significantly larger in GP/MPs and BAs with a GP/MP-like morphology (103 to 242 µm) than in flat-predominant BA (23 to 47 µm, P=0.0010). AKT1 E17K mutations were detected in all GP/MPs and BAs with GP/MP-like morphology but were absent in the 5 flat-predominant BAs. AKT1 mutations were always concurrent with BRAF or HRAS mutations, and the variant allele frequency or percentage of mutant copies of AKT1 mutations was equal to those of BRAF or HRAS mutations. GP/MPs are characterized by AKT1 mutations concurrent with BRAF or HRAS mutations. Peribronchiolar papillary tumors with AKT1 mutations may also be classified as GP/MP.


Assuntos
Adenoma/genética , Neoplasias Pulmonares/genética , Papiloma/genética , Proteínas Proto-Oncogênicas c-akt/genética , Adenoma/patologia , Idoso , Idoso de 80 Anos ou mais , Biomarcadores Tumorais/genética , Bronquíolos/patologia , Feminino , Humanos , Neoplasias Pulmonares/patologia , Masculino , Pessoa de Meia-Idade , Mutação , Papiloma/patologia
2.
BMJ Case Rep ; 13(12)2020 Dec 22.
Artigo em Inglês | MEDLINE | ID: mdl-33370999

RESUMO

Juvenile respiratory laryngeal papillomatosis is a subset of a larger clinical entity of recurrent respiratory papillomatosis. It is characterised by the development of recurrent papillomata in the vocal folds. Human papillomavirus types 6 and 11 has been implicated to be the most common strain of virus associated with the formation of laryngeal papilloma. Clinical diagnosis is based on typical appearance of warty lesion on endoscopy. Surgery is the primary line of management along with adjuvant therapy like antiviral drugs and immunomodulators. Thuja occidentalis is a tree native to North America whose leaves and leaf oil have antiviral, antibacterial and antifungal properties. It has been widely used for the treatment of condylomatous skin lesions and warts. Here we discuss the outcome of thuja as an adjuvant therapy in the treatment of laryngeal papillomatosis in an 8-year-old child.


Assuntos
Neoplasias Laríngeas/terapia , Recidiva Local de Neoplasia/terapia , Papiloma/terapia , Extratos Vegetais/administração & dosagem , Thuja/química , Traqueostomia , Quimioterapia Adjuvante/métodos , Criança , Relação Dose-Resposta a Droga , Esquema de Medicação , Humanos , Neoplasias Laríngeas/diagnóstico , Neoplasias Laríngeas/patologia , Laringoscopia , Laringe/diagnóstico por imagem , Laringe/patologia , Laringe/cirurgia , Masculino , Recidiva Local de Neoplasia/diagnóstico , Papiloma/diagnóstico , Papiloma/patologia , Reoperação , Resultado do Tratamento
3.
Washington, D.C.; PAHO; 2020-12-28.
em Inglês | PAHO-IRIS | ID: phr-53167

RESUMO

Vaccines save between 2 million and 3 million lives each year and protect the entire population from more than a dozen life-threatening diseases. Thanks to vaccination, smallpox was eradicated in 1980, and we are on track to eradicate polio. However, despite great strides in the control of measles, one of the most contagious diseases known, the last few years have unfortunately seen an increase in cases. This is why high vaccination coverage—95% or more—is needed, posing a major technical and communication challenge for health workers. Studies show that telling people about the quality, safety, effectiveness and availability of vaccines is not enough to influence behavior change related to immunization, and in general, doesn´t increase coverage. For this reason, it´s necessary to understand the reasons why people choose not to get vaccinated or not get their children vaccinated, in order to begin a two-way respectful dialogue using the best, most effective messages. Given this context, the main objective of these guidelines is to provide tools for staff working in the field of immunization to support effective communication between health personnel and the general population, with the aim of strengthening, maintaining or recovering trust in vaccines and the immunization programs in the Region of the Americas.


Assuntos
Vacinas , Vacinação , Imunização , Família , Cuidadores , Infecções por Coronavirus , Coronavirus , Infecções por Coronavirus , Vacina Quadrivalente Recombinante contra HPV tipos 6, 11, 16, 18 , Papiloma , Infecções por Papillomavirus , Vacinas contra Papillomavirus , Sarampo , Vacinas contra Influenza , Vacina contra Sarampo , Vírus da Influenza A , Vírus da Influenza B , Influenzavirus C , Vacina contra Sarampo-Caxumba-Rubéola
4.
Washington, D.C.; OPS; 2020-11-11.
em Espanhol | PAHO-IRIS | ID: phr-53014

RESUMO

Las vacunas salvan entre 2 y 3 millones de vidas cada año y protegen a toda la población contra más de una docena de enfermedades potencialmente mortales. Gracias a la vacunación se erradicó la viruela en el año 1980 y estamos en vías de erradicar la poliomielitis. No obstante, en los últimos años ha habido un aumento en los casos de sarampión, una de las enfermedades conocidas más contagiosas. Por esta razón es necesario alcanzar una cobertura de vacunación de 95% o más, lo que constituye un gran desafío técnico y de comunicación para el personal de salud. Los estudios demuestran que informar sobre la calidad, la seguridad, la eficacia y la oferta de las vacunas no es suficiente para lograr cambios de conducta frente a la vacunación y que, en general, no aumenta su cobertura. Por este motivo, es necesario comprender las razones que llevan a las personas a no vacunarse o a no vacunar a sus hijos, con vistas a iniciar un diálogo bidireccional basado en el respeto que redunde en mensajes mejores y más eficaces. En este contexto, las presentes orientaciones tienen como objetivo principal facilitar a los equipos de salud herramientas que sirvan de apoyo para la comunicación efectiva entre el personal de salud y la población general, con miras a lograr el objetivo de fortalecer, mantener o recuperar la confianza en las vacunas y en los programas de inmunización en la Región de las Américas.


Assuntos
Imunização , Vacinas , Vacinação , Cuidadores , Família , Infecções por Coronavirus , Coronavirus , Infecções por Coronavirus , Vacina Quadrivalente Recombinante contra HPV tipos 6, 11, 16, 18 , Papiloma , Sarampo , Vacinas contra Influenza , Vírus da Influenza A , Vírus da Influenza B , Influenzavirus C , Vacina contra Sarampo-Caxumba-Rubéola
5.
Rev Assoc Med Bras (1992) ; 66(9): 1247-1251, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-33027453

RESUMO

BACKGROUND: Recurrent laryngeal papillomatosis, caused by the Human Papilloma Virus, has a significant economic impact worldwide and there are no epidemiological data of this disease in Brasil. OBJECTIVE: The objective of the study was to estimate the incidence and prevalence of laryngeal papillomatosis of some otorhinolaryngology centers in São Paulo State (Brasil). METHODS: A questionnaire containing data on the number of new and follow-up cases diagnosed with laryngeal papillomatosis was sent to the Otorhinolaryngology services (n=35) of São Paulo State (Brasil). RESULTS: A total of 20 otorhinolaryngology centers answered the questionnaire. Of these, the five largest regional health centers were selected as follows: Campinas (42 cities - 4,536,657 inhabitants), Sao Jose do Rio Preto (102 cities - 1,602,845 inhabitants), Ribeirão Preto (26 cities - 1,483,715 inhabitants), Bauru (68 cities - 1,770,427 inhabitants), and Sorocaba (47 cities - 2,478,208 inhabitants). The incidence and prevalence of each regional health centers were, respectively: Campinas (5.51;7.27), Sorocaba (2.02;6.86), São José do Rio Preto (1.87;7.49), Ribeirão Preto (11.46;22.92), and Bauru (3.95;7.91). CONCLUSION: The incidence and prevalence of the laryngeal papillomatosis of the five largest regional health centers of the interior of São Paulo State (Brasil) varied between 1.87 to 11.46 and 6.86 to 22.92 per 1,000,000 inhabitants, respectively for a total population of 11,871,852 inhabitants.


Assuntos
Neoplasias Laríngeas , Papiloma , Brasil/epidemiologia , Cidades , Humanos , Incidência , Neoplasias Laríngeas/epidemiologia , Papiloma/epidemiologia , Prevalência
7.
Niger J Clin Pract ; 23(9): 1324-1327, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32913175

RESUMO

Infiltrating syringomatous adenoma of the nipple (SAN) is a rare benign neoplasm of the breast that is often misdiagnosed. SAN may present with a subareolar lesion and clinical, mammographic, and ultrasonographic findings associated with malignancy. We present the case of a 60-year-old woman with a painful, firm, solid tumor in her left breast and deformation of the left nipple-areolar complex (NAC). Histopathological test results were conflicting. The tumor, including the NAC were locally excised. Postsurgical immuno-histochemical tests revealed squamous histology, whereas myoepithelial cells were present in the resected specimen, a feature consistent with SAN. The pathologist noted microscopically positive surgical margins. Three months after surgery, tumor recurrence occurred. The patient underwent revision surgery with wide excision of the skin and gland around the lesion, followed by immediate breast reconstruction, using a pedicled myocutaneous latissimus dorsi (pLD) flap. Extreme care should be taken when diagnosing SAN to ensure proper treatment and prevent recurrence.


Assuntos
Adenoma/cirurgia , Erros de Diagnóstico/efeitos adversos , Recidiva Local de Neoplasia/cirurgia , Mamilos/cirurgia , Siringoma/cirurgia , Adenoma/patologia , Neoplasias da Mama/patologia , Neoplasias da Mama/cirurgia , Feminino , Humanos , Mamoplastia , Mamografia , Pessoa de Meia-Idade , Recidiva Local de Neoplasia/patologia , Mamilos/patologia , Papiloma/patologia , Papiloma/cirurgia , Siringoma/diagnóstico , Siringoma/patologia , Resultado do Tratamento
8.
Clin Nucl Med ; 45(10): 798-799, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32804763

RESUMO

Biliary papillomatosis is a rare disease with high malignant potential. A 64-year-old woman underwent FDG PET/CT, which showed an intense FDG uptake in the location of an aggregated biliary papillomatosis with high-grade intraepithelial neoplasia/carcinoma in situ but did not show FDG uptake in the sporadic, small biliary papilloma. FDG PET/CT may be an effective method to identify the components of the malignant transformation of biliary papillomatosis.


Assuntos
Neoplasias dos Ductos Biliares/diagnóstico por imagem , Fluordesoxiglucose F18 , Papiloma/diagnóstico por imagem , Tomografia Computadorizada com Tomografia por Emissão de Pósitrons , Neoplasias dos Ductos Biliares/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Gradação de Tumores , Papiloma/patologia
9.
Korean J Radiol ; 21(8): 955-966, 2020 08.
Artigo em Inglês | MEDLINE | ID: mdl-32677380

RESUMO

Ultrasound (US) is an attractive diagnostic approach to identify both common and uncommon nipple pathologies, such as duct ectasia, nipple abscess, nipple leiomyoma, nipple adenoma, fibroepithelial polyp, ductal carcinoma in situ (restricted to nipple), invasive carcinoma, and Paget's disease. US is the reliable first-line imaging technique to assess nipple pathologies. It is useful to identify and characterize nipple lesions. Additionally, we have presented the mammography and MRI outcomes correlated with histopathologic features for the relevant cases.


Assuntos
Adenoma/diagnóstico por imagem , Neoplasias da Mama/diagnóstico por imagem , Carcinoma Intraductal não Infiltrante/diagnóstico por imagem , Mamilos/diagnóstico por imagem , Doença de Paget Mamária/diagnóstico por imagem , Papiloma/diagnóstico por imagem , Ultrassonografia/métodos , Adenoma/patologia , Adulto , Idoso , Neoplasias da Mama/patologia , Carcinoma Intraductal não Infiltrante/patologia , Feminino , Humanos , Imagem por Ressonância Magnética/métodos , Mamografia/métodos , Pessoa de Meia-Idade , Mamilos/patologia , Doença de Paget Mamária/diagnóstico , Doença de Paget Mamária/patologia , Papiloma/patologia
10.
Nat Commun ; 11(1): 2711, 2020 06 01.
Artigo em Inglês | MEDLINE | ID: mdl-32483135

RESUMO

p16INK4a (CDKN2A) is a central tumor suppressor, which induces cell-cycle arrest and senescence. Cells expressing p16INK4a accumulate in aging tissues and appear in premalignant lesions, yet their physiologic effects are poorly understood. We found that prolonged expression of transgenic p16INK4a in the mouse epidermis induces hyperplasia and dysplasia, involving high proliferation rates of keratinocytes not expressing the transgene. Continuous p16INK4a expression increases the number of epidermal papillomas formed after carcinogen treatment. Wnt-pathway ligands and targets are activated upon prolonged p16INK4a expression, and Wnt inhibition suppresses p16INK4a-induced hyperplasia. Senolytic treatment reduces p16INK4a-expressing cell numbers, and inhibits Wnt activation and hyperplasia. In human actinic keratosis, a precursor of squamous cell carcinoma, p16INK4a-expressing cells are found adjacent to dividing cells, consistent with paracrine interaction. These findings reveal that chronic p16INK4a expression is sufficient to induce hyperplasia through Wnt-mediated paracrine stimulation, and suggest that this tumor suppressor can promote early premalignant epidermal lesion formation.


Assuntos
Transformação Celular Neoplásica/genética , Inibidor p16 de Quinase Dependente de Ciclina/genética , Epiderme/metabolismo , Via de Sinalização Wnt/genética , Animais , Proliferação de Células/genética , Transformação Celular Neoplásica/metabolismo , Células Cultivadas , Inibidor p16 de Quinase Dependente de Ciclina/metabolismo , Humanos , Hiperplasia/genética , Hiperplasia/metabolismo , Queratinócitos/metabolismo , Ceratose/genética , Ceratose/metabolismo , Camundongos da Linhagem 129 , Camundongos Endogâmicos C57BL , Camundongos Transgênicos , Papiloma/genética , Papiloma/metabolismo , Papiloma/patologia
11.
J Zoo Wildl Med ; 51(2): 357-362, 2020 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-32549565

RESUMO

Techniques for anesthesia of green sea turtles (Chelonia mydas) are required for medical treatment. The use of spinal anesthesia has been reported in a few species of turtles for different purposes. The objective of this study was to evaluate the use of 2% lidocaine for spinal anesthesia of green sea turtles undergoing surgical removal of cutaneous fibropapillomas. Ten free-ranging green turtles presenting with cutaneous fibropapillomas were included in the study. Animals were accidentally captured or rescued by local fishermen and brought to the Ubatuba Research Base (Sao Paulo, Brazil) of the Brazilian Sea Turtle Conservation Program for rehabilitation. Animals were administered 2% lidocaine (0.2 ml/10 cm of carapace) in the epidural/subarachnoid space of the tail and monitored throughout surgery. The technique was effective for all animals, with fast onset of motor and sensory blockade (3 ± 1.76 min) and relatively fast recovery time (83.9 ± 16.2 min). Fibropapillomas were removed from all animals with no signs of pain (i.e., no behavioral response during surgical procedure, such as head and forelimb movement, showing discomfort) and they were all rehabilitated and successfully returned to their natural habitat. The technique was considered effective, safe, and affordable for use on green turtles undergoing surgical removal of cutaneous fibropapillomas.


Assuntos
Raquianestesia/veterinária , Anestésicos Locais/administração & dosagem , Lidocaína/administração & dosagem , Papiloma/veterinária , Neoplasias Cutâneas/veterinária , Tartarugas/cirurgia , Animais , Animais Selvagens/cirurgia , Brasil , Papiloma/cirurgia , Neoplasias Cutâneas/cirurgia
13.
Eur Urol Focus ; 6(5): 1058-1069, 2020 Sep 15.
Artigo em Inglês | MEDLINE | ID: mdl-32527624

RESUMO

CONTEXT: The coronavirus disease 2019 (COVID-19) pandemic raised concerns about the safety of laparoscopy due to the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diffusion in surgical smoke. Although no case of SARS-CoV-2 contagion related to surgical smoke has been reported, several international surgical societies recommended caution or even discouraged the use of a laparoscopic approach. OBJECTIVE: To evaluate the risk of virus spread due to surgical smoke during surgical procedures. EVIDENCE ACQUISITION: We searched PubMed and Scopus for eligible studies, including clinical and preclinical studies assessing the presence of any virus in the surgical smoke from any surgical procedure or experimental model. EVIDENCE SYNTHESIS: We identified 24 studies. No study was found investigating SARS-CoV-2 or any other coronavirus. About other viruses, hepatitis B virus was identified in the surgical smoke collected during different laparoscopic surgeries (colorectal resections, gastrectomies, and hepatic wedge resections). Other clinical studies suggested a consistent risk of transmission for human papillomavirus (HPV) in the surgical treatments of HPV-related disease (mainly genital warts, laryngeal papillomas, or cutaneous lesions). Preclinical studies showed conflicting results, but HPV was shown to have a high risk of transmission. CONCLUSIONS: Although all the available data come from different viruses, considering that the SARS-CoV-2 virus has been shown in blood and stools, the theoretical risk of virus diffusion through surgical smoke cannot be excluded. Specific clinical studies are needed to understand the effective presence of the virus in the surgical smoke of different surgical procedures and its concentration. Meanwhile, adoption of all the required protective strategies, including preoperative patient nasopharyngeal swab for COVID-19, seems mandatory. PATIENT SUMMARY: In this systematic review, we looked at the risk of virus spread from surgical smoke exposure during surgery. Although no study was found investigating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or any other coronavirus, we found that the theoretical risk of virus diffusion through surgical smoke cannot be excluded.


Assuntos
Betacoronavirus , Infecções por Coronavirus/transmissão , Vírus da Hepatite B , Transmissão de Doença Infecciosa do Paciente para o Profissional , Laparoscopia , Papillomaviridae , Pneumonia Viral/transmissão , Fumaça , Colectomia , Condiloma Acuminado/cirurgia , Condiloma Acuminado/virologia , Gastrectomia , Hepatectomia , Humanos , Neoplasias Laríngeas/cirurgia , Neoplasias Laríngeas/virologia , Procedimentos Cirúrgicos Minimamente Invasivos , Pandemias , Papiloma/cirurgia , Papiloma/virologia , Infecções por Papillomavirus , Risco , Verrugas/cirurgia , Verrugas/virologia
14.
Arq. bras. med. vet. zootec. (Online) ; 72(3): 926-930, May-June, 2020. ilus, tab, graf
Artigo em Inglês | LILACS, VETINDEX | ID: biblio-1129601

RESUMO

Papillomatosis is one of the few diseases in which autovaccine therapy is recommended, especially in the case of mass manifestation in animals. It is noted that papillomas are diagnosed in 15.7% of cases in histological diagnosis of oncological diseases. Therefore, this work studied the profile of oncological diseases in dogs and the clinical effectiveness of autovaccine therapy of papillomatosis. The article gives a morphological description of papillomas used as a biomaterial, and also describes the technological methods of manufacturing an autovaccine used to treat animals against papillomatosis. A therapeutic scheme for administering the vaccine was proposed and tested, and the results of the clinical trial are presented, as well as a reflection on some moments of the mechanism of vaccine therapy for papillomatosis.(AU)


A papilomatose é uma das poucas doenças onde se recomenda a terapia com autovacina, principalmente no caso de manifestação em massa em animais. Nota-se que papilomas são diagnosticados em 15,7% dos casos em diagnóstico histológico de doenças oncológicas. Portanto, este trabalho estudou o perfil das doenças oncológicas em cães e a eficácia clínica da terapia com autovacina em papilomatose. O presente artigo fornece descrição morfológica dos papilomas utilizados como biomaterial, além da descrição dos métodos tecnológicos de fabricação de uma autovacina usada para tratar animais contra a papilomatose. Um esquema terapêutico para a administração da vacina foi proposto e testado, e os resultados do ensaio clínico são apresentados, e é feita uma reflexão sobre alguns momentos do mecanismo da terapia de vacina para papilomatose.(AU)


Assuntos
Animais , Cães , Papiloma/veterinária , Papiloma/epidemiologia , Células Epiteliais/patologia , Autovacinas/uso terapêutico , Imunoterapia/veterinária
15.
Rev. otorrinolaringol. cir. cabeza cuello ; 80(2): 209-217, jun. 2020. tab, graf
Artigo em Espanhol | LILACS | ID: biblio-1115837

RESUMO

El vestíbulo nasal corresponde a la primera porción de la fosa nasal, éste se encuentra delimitado lateralmente por los cartílagos alares y medialmente por el borde caudal del septum nasal y la columela. Las enfermedades infecciosas del vestíbulo nasal son patologías frecuentes en la práctica clínica; su diagnóstico se realiza en base a sospecha clínica y examen físico, requiriendo habitualmente solo manejo médico ambulatorio. Desde el punto de vista etiológico pueden ser virales, bacterianas y fúngicas. Las principales especies bacterianas involucradas corresponden a Staphylococcus coagulasa negativa, S. epidermidis, S. hominis y S. haemolyticus, difteroides spp y S. aureus. Su manejo es esencialmente médico con casos excepcionales requiriendo manejo quirúrgico. En la actualidad existe escasa información epidemiológica al respecto, lo que dificultad la clasificación de los dichos cuadros clínicos. Se realizó una revisión de la literatura sobre cuadros infecciosos que afectan el vestíbulo nasal para lograr sistematizar y clarificar las distintas patologías y sus tratamientos.


The nasal vestibule corresponds to the first portion of the nasal passage, limited laterally by the lateral crus and medially by the caudal edge of the nasal septum and columella. Infectious diseases of the nasal vestibule are frequent in clinical practice, diagnosis is made based on clinical suspicion and physical examination, usually requiring only ambulatory medical management. In terms of etiology, they can be viral, bacterial and fungal. The main bacterial species involved correspond: Coagulase-negative Staphylococcus, S. epidermidis, S. hominis and S. haemolyticus, difteroides spp and S. aureus. Management is essentially medical and only exceptionally requires surgery. Currently, there is a lack of epidemiological information in this regard, which makes it difficult to classify these clinical conditions. A review of the literature on infectious conditions that affect the nasal vestibule was performed, to systematize and clarify the different pathologies and their management.


Assuntos
Humanos , Infecções Bacterianas/complicações , Doenças Nasais/etiologia , Cavidade Nasal/microbiologia , Papiloma/complicações , Staphylococcus aureus , Staphylococcus epidermidis , Rinoscleroma/complicações , Doenças Nasais/microbiologia , Fatores de Risco , Staphylococcus haemolyticus , Staphylococcus hominis , Foliculite/complicações , Cavidade Nasal/patologia
16.
Rev. cuba. oftalmol ; 33(2): e816, graf
Artigo em Espanhol | LILACS, CUMED | ID: biblio-1139082

RESUMO

RESUMEN El papiloma conjuntival es un tumor de células escamosas adquirido, benigno, que se puede presentar a cualquier edad, pero más frecuentemente en la tercera y cuarta décadas de la vida. Los papilomas están asociados con la infección del virus papiloma humano, usualmente los tipos 6 y 11. Se presenta un paciente quien se encuentra en la cuarta década de la vida, fumador. Acudió al Servicio de Oculoplastia por aumento del volumen conjuntival en el ojo izquierdo. Luego del interrogatorio y de un examen ocular exhaustivo, se realizó el diagnóstico clínico de papiloma conjuntival recurrente. Se propuso exéresis, crioterapia y biopsia de las lesiones conjuntivales. Posterior a la intervención, se confirmó el diagnóstico anatomopatológico y se reajustó el tratamiento tópico ocular con interferón, con lo cual se obtuvieron resultados satisfactorios(AU)


ABSTRACT Conjunctival papilloma is a benign acquired squamous cell tumor occurring at any age, but more commonly in the third and fourth decades of life. Papillomas are associated to human papillomavirus infection, usually of types 6 and 11. A case is presented of a male smoker patient in his fourth decade of life. The patient attended the Oculoplastics Service due to conjunctival volume increase in his left eye. Interrogation and exhaustive ocular examination led to the clinical diagnosis of recurrent conjunctival papilloma. Exeresis, cryotherapy and biopsy of the conjunctival lesions were indicated. The anatomopathological diagnosis was confirmed after the intervention and a readjustment was made of the topical ocular treatment with interferon, with which satisfactory results were obtained(AU)


Assuntos
Humanos , Masculino , Adulto , Papiloma/diagnóstico , Interferons/uso terapêutico , Crioterapia/métodos , Infecções por Papillomavirus/etiologia
17.
Gan To Kagaku Ryoho ; 47(1): 153-155, 2020 Jan.
Artigo em Japonês | MEDLINE | ID: mdl-32381889

RESUMO

We report a case of papilloma of the breast with rapid growth in a 39-year-old female who had a lump in the left breast. The follow-up for the breast tumor was performed at another hospital.Three years after her first visit, 3 tumors measuring 1.8 cm, 0.5 cm, and 0.3 cm in diameter were detected. The patient visited our hospital to diagnose these tumors. We performed core needle biopsy for the tumor, and the pathological diagnosis was benign papilloma.After 1 year, the tumor grew to 3.0 cm in diameter, and we repeated the core needle biopsy. The pathological diagnosis remained as benign papilloma; however, the ultrasonography and MRI results showed that the tumor was malignant.Surgical resection was performed for the tumors, and pathological analysis of the surgical specimen revealed 3 benign papillomas with no involvement of the surgical margin.Six years after surgery, no recurrence was reported.


Assuntos
Neoplasias da Mama , Papiloma Intraductal , Papiloma , Adulto , Feminino , Humanos , Recidiva Local de Neoplasia
19.
Aust Vet J ; 98(8): 405-410, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32390155

RESUMO

OBJECTIVE: The aim of this study was to evaluate formalin-inactivated autovaccination to treat cutaneous papillomatosis and to perform molecular typing of the papillomavirus in four horses (two foals, one 3-year-old filly and a 5-year-old stallion). METHODS: Histopathological slides of lesions were prepared and stained with haematoxylin and eosin (H&E) to establish a diagnosis that was based on observation koilocytosis, which is a pathognomonic cytopathic change that is associated with papillomatosis, using light microscopy. Polymerase chain reaction (PCR) and DNA sequencing were performed using the EPV-R and EPV-F primer set. RESULTS: In histopathological examination, koilocyte formation and occasional intranuclear viral inclusions were detected in the papillomas. A 334-base pair (bp) fragment of the E2 and L2 genes from the EPV genome was amplified using the EPV-R and EPV-F primer set. This fragment contained 215 bp from the E2 gene and 56 bp from the L2 gene; these were found to be 98.78% to 98.97% identical to the known EcPV type-1 sequence (AF498323). CONCLUSION: Three horses with cutaneous papillomatosis were administered two doses of a formalin-inactivated preparation of papillomatous lesions at 7-day intervals. The papillomatous lesions were observed to decrease gradually 1 week after the last vaccination, and all warts had resolved within 2-3 weeks. One horse with cutaneous papillomatosis was left as an unvaccinated control, and no changes to the lesions were noted. To the best of our knowledge, this is the first report of EcPV type-1 infection, autovaccine preparation and molecular typing in Turkey.


Assuntos
Doenças dos Cavalos , Papiloma/veterinária , Papillomaviridae/genética , Animais , DNA Viral , Feminino , Cavalos , Masculino , Tipagem Molecular/veterinária , Turquia
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