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1.
J Int Med Res ; 50(9): 3000605221121964, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-36071632

RESUMO

An extraintestinal fistula is a rare complication after appendectomy. To our knowledge, this study is the first to report a case of sigmoid abdominal wall fistula after appendectomy in a 45-year-old male patient who underwent appendectomy due to acute appendicitis. Purulent discharge was noted at the abdominal wall incision wound for more than 1 year postoperatively. The patient's clinical manifestation, medical history, physical examination, and auxiliary examination all suggested the formation of an abdominal sinus. After exploratory laparotomy at the Digestive Disease Hospital, Affiliated Hospital of Zunyi Medical University, a diagnosis of sigmoid abdominal wall fistula was confirmed, and the fistula was cured after complete fistula resection. The reporting of this rare and atypical case may provide useful reference information for diagnosing and treating future cases of enterocutaneous fistula.


Assuntos
Parede Abdominal , Apendicite , Fístula Intestinal , Parede Abdominal/cirurgia , Apendicectomia/efeitos adversos , Apendicite/diagnóstico , Apendicite/cirurgia , Humanos , Fístula Intestinal/diagnóstico por imagem , Fístula Intestinal/etiologia , Laparotomia/efeitos adversos , Masculino , Pessoa de Meia-Idade
2.
Rom J Morphol Embryol ; 63(1): 191-195, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36074683

RESUMO

Synovial sarcoma (SS) usually affects joints, bursae, and tendons of extremities and is very infrequent in the head and neck, abdomen, thorax, prostate and kidney, skin, blood vessels, and nerves. Primary intra-abdominal SS is exceeding uncommon and has non-specific symptoms or compress surrounding structures. The diagnosis is a challenge, and histopathological and immunohistochemical studies must confirm the hypothesis. We report the case of SS that has origin in peritoneal structures and a longstanding unsuspected course. The patient was a 64-year-old woman who claimed chronic pain in the left iliac fossa, without additional symptoms. She related laparoscopic oophorectomy, cholecystectomy, and abdominal hysterectomy in the previous three decades. There was neither local invasion nor lymph nodal, vascular or neural invasion, and her surgical treatment by open abdominal procedure was uneventful. The herein reported case aims to enhance the index of suspicion.


Assuntos
Parede Abdominal , Sarcoma Sinovial , Parede Abdominal/patologia , Feminino , Humanos , Histerectomia , Masculino , Pessoa de Meia-Idade , Sarcoma Sinovial/diagnóstico , Sarcoma Sinovial/patologia , Tórax
3.
Rozhl Chir ; 101(7): 337-341, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36075697

RESUMO

INTRODUCTION: Aggressive fibromatosis, also known as desmoid tumour (DT), is a locally invasive soft tissue malignancy originating from fascial planes, connective tissue, and musculoaponeurotic structures of the muscles. The symptoms greatly depend on the location and size of the tumour. CASE REPORT: A 68-year-old male patient without any comorbidities with a large, palpable mass in the abdomen underwent computed tomography (CT) of the abdomen during diagnostic examination in September 2017 in another centre. The CT scan revealed a giant intraperitoneal 30×40cm tumour without signs of infiltrating the surrounding organs and large vessels. The tumour biopsy revealed an aggressive DT. The patient was scheduled for tumour resection. Midline laparotomy was performed in the supine position under general anaesthesia. After gaining access to the abdominal cavity, 8 litres of clear ascites were evacuated. The tumour was not attached to the abdominal wall. Large omentum was freed from the DT. The perioperative finding confirmed the CT images of DT encapsulation of the medial colic artery, part of the small intestine, and transverse colon. The tumour was resected with part of the mesenteric radix, 30 cm of small intestine, and 2/3 of the transverse colon. After the DT was removed entirely, the small intestine was re-anastomosed end to end. The abdominal cavity and the liver were carefully checked for bleeding. The abdominal cavity was closed in a standard manner. RESULTS: The postoperative hospital stay was uneventful. The patient was discharged on the 7th postoperative day with prophylactic low weight molecular heparin for one month. Currently, we have five months of follow-up with no signs of DT recurrence based on CT examination. The histology of the resected tumour confirmed the diagnosis of a desmoid tumour (aggressive abdominal fibromatosis). CONCLUSION: Desmoid tumours are benign neoplasms with no metastatic potential. However, their treatment is challenging due to their aggressive growth, infiltrative behaviour, and a high tendency to recur.


Assuntos
Parede Abdominal , Fibromatose Agressiva , Parede Abdominal/cirurgia , Idoso , Fibromatose Agressiva/diagnóstico por imagem , Fibromatose Agressiva/cirurgia , Humanos , Laparotomia , Masculino , Mesentério/cirurgia , Tomografia Computadorizada por Raios X
5.
Pan Afr Med J ; 42: 54, 2022.
Artigo em Francês | MEDLINE | ID: mdl-35949478

RESUMO

Abdominal wall endometriosis is a rare disease that usually develops in association with a cesarean section scar. Although frequently identified in the skin and subcutaneous adipose tissue adjacent to the cesarean scar, intramuscular localization is possible but rare. Treatment is based on surgical excision of the lesion associated with or without hormone therapy. Wide surgical excision is the treatment of choice, but it exposes to the risk of abdominal wall hernia. We here report two cases of parietal endometriosis occurring after Pfannstiel scar for cesarean section whose data were collected at the Department of surgery in the Zaghouan Regional Hospital.


Assuntos
Parede Abdominal , Endometriose , Parede Abdominal/patologia , Parede Abdominal/cirurgia , Cesárea , Cicatriz/patologia , Endometriose/complicações , Endometriose/diagnóstico , Endometriose/cirurgia , Feminino , Humanos , Gravidez
7.
Cir. Esp. (Ed. impr.) ; 100(8): 464-471, ago. 2022. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-207746

RESUMO

La terapia de presión negativa (TPN) para el tratamiento de las heridas es ampliamente conocida en la práctica quirúrgica. Las indicaciones iniciales de la TPN fueron las heridas crónicas, sobre todo úlceras de pie diabético, vasculares y por decúbito, y las heridas infectadas traumáticas. En la actualidad, el uso se ha diversificado ampliamente. Aunque en el campo de la cirugía de pared abdominal se ha utilizado principalmente en el manejo de las complicaciones de la herida quirúrgica tras la reparación herniaria, otras indicaciones han sido añadidas tras adquirir la experiencia durante años en el manejo de la TPN. Por ello, el objetivo de este artículo es analizar y revisar las principales indicaciones de la TPN en la cirugía de pared abdominal, así como las ventajas que se obtienen con su aplicación (AU)


Negative pressure wound therapy (NPWT) is widely known in surgical practice. The initial indications for NPWT were chronic wounds, especially diabetic foot, vascular and decubitus ulcers, and infected traumatic wounds. Nowadays, the use has been widely increased. Although in the field of abdominal wall surgery, it has mainly been used in the treatment of surgical wound complications after hernia repair, other indications have been added after years of experience in the management of NPWT. Therefore, the aim of this article is to analyze and review the main indications of NPWT in abdominal wall surgery, as well as the advantages obtained with its application (AU)


Assuntos
Humanos , Tratamento de Ferimentos com Pressão Negativa , Parede Abdominal/cirurgia , Herniorrafia/métodos
8.
BMC Surg ; 22(1): 305, 2022 Aug 08.
Artigo em Inglês | MEDLINE | ID: mdl-35941642

RESUMO

BACKGROUND: Post-partum abdominal wall insufficiency (PPAWI) with rectus diastasis is present in over 30% of women after pregnancy. Little is known about how PPAWI affects the social, sexual life and self-esteem of patients. This study was designed to evaluate the safety of onlay mesh combined with abdominoplasty and its impact on the well-being of the patients. METHOD: Two hundred patients with PPAWI underwent surgery with onlay mesh and abdominoplasty. The safety of the procedure was assessed by postoperative complications, time of hospitalization and time of drainage. Before the operation and 6 months later, a questionnaire asking about the patient's sexual and social life and the presence of back pain was completed. The final cosmetic effect was assessed separately. RESULTS: The onlay procedure with abdominoplasty was found to be safe and fast. The mean operation time was 82 min, and the drainage time was 2.1 days. In this group < 2% postoperative complications were noted. There were no recurrences within the 6 month. Significant improvements in social and sexual life and the level of self-esteem were noted. Back pain was relieved or minimalized in all patients. The final cosmetic effect was insufficient for 2 patients (1%). CONCLUSION: PPAWI can be treated safely with onlay mesh and abdominoplasty. The patients' symptoms were strongly correlated with the morphological status of the front abdominal wall and improved after the procedure. Describing the psychological and social consequences of PPAWI should lead the surgical societies to propose a definition of a new disease called PPAWIS (post-partum abdominal wall insufficiency syndrome).


Assuntos
Parede Abdominal , Cirurgiões , Parede Abdominal/cirurgia , Dor nas Costas , Feminino , Humanos , Complicações Pós-Operatórias/epidemiologia , Período Pós-Parto , Gravidez , Telas Cirúrgicas/efeitos adversos
9.
Can J Surg ; 65(4): E541-E549, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35961662

RESUMO

BACKGROUND: Complex abdominal wall reconstruction technique remains controversial. The use of biologic mesh products is also debated in active infection, sepsis prophylaxis and high-risk patients. Differences in biologic mesh technology and cost remain significant. We aimed to compare the efficacy of 2 commonly used biologic meshes in regards to hernia recurrence at 1 year. METHODS: This study was a parallel, dual-arm, double-blind randomized controlled trial involving adult patients undergoing complex abdominal wall reconstruction with a biologic mesh at a quaternary care institution (2017-2020). Patients were randomly assigned to receive Permacol (cross-linked) compared with Strattice (not crosslinked). The main outcome measure was hernia recurrence at 1 or more years following the index repair. RESULTS: We included 94 patients randomized to undergo reconstruction with 1 of 2 commonly used biologic mesh products (mean age 59.4 yr, standard deviation [SD] 9.9; 51% female; body mass index 32.9, SD 6.8). We found no significant differences between the groups (patient comorbidities, hernia recurrence risk factors, hernia size or infection profiles). Hernia recurrence rates (15%) were similar between groups (median 783 days of follow up, interquartile range 119). We found there was significantly less of a need for a component separation technique in the Strattice group (69% v. 87%). All other secondary outcome measures were equivalent between study arms. Multivariate analysis identified hepatic transplantation (odds ratio [OR] 1.94, 95% confidence intervals [CI] 0.33-4.41), active abdominal wall infection (OR 2.01, 95% CI 0.50-7.01), and more than 1 previous hernia repair (OR 2.68, 95% CI 0.41-5.99) as risk factors for subsequent hernia recurrence; however, there was no difference in recurrence factors between patient study groups. CONCLUSION: Given similar clinical performance between the 2 most commonly used biologic mesh products, the most cost effective mesh should be used in cost-conscious health care systems.


Assuntos
Parede Abdominal , Produtos Biológicos , Hérnia Ventral , Parede Abdominal/cirurgia , Adulto , Feminino , Hérnia Ventral/prevenção & controle , Hérnia Ventral/cirurgia , Herniorrafia/efeitos adversos , Herniorrafia/métodos , Humanos , Masculino , Pessoa de Meia-Idade , Recidiva , Estudos Retrospectivos , Telas Cirúrgicas , Resultado do Tratamento
10.
Cir Cir ; 90(4): 447-453, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35944431

RESUMO

OBJECTIVE: Abdominal wall hernias (AWH) may turn into a complex condition in terms of emergency. This study aims to evaluate the factors which may lead emergency AWH operation to complex surgery. MATERIALS AND METHODS: Univariate and multivariate regression analysis is performed to determine independent factors affecting tissue resection, bowel resection, and surgical-site complications. RESULTS: The type of hernia, time, and content of hernia are independent factors for tissue resection. The time elapsed from the onset of complaints to surgery and comorbid diseases are independent factors for bowel resection. Similarly, the time elapsed from the onset of complaints to surgery and bowel presence in hernia is independent risk factors for surgical-site complications. CONCLUSION: Patients who are operated later than 6 h after the onset of complaints and have comorbidity are more complex surgery.


OBJETIVO: Las hernias de la pared abdominal pueden convertirse en un cuadro complejo en términos de urgencia. Este estudio tiene como objetivo evaluar los factores que pueden llevar a una operación de hernia de la pared abdominal de emergencia a una cirugía compleja. MATERIALS Y MÉTODOS: Se realiza un análisis de regresión univariado y multivariado para determinar los factores independientes que afectan la resección de tejido, la resección intestinal y las complicaciones del sitio quirúrgico. RESULTADOS: El tipo de hernia, el tiempo y el contenido de la hernia son factores independientes para la resección del tejido. El tiempo transcurrido desde el inicio de las molestias hasta la cirugía y las enfermedades comórbidas son factores independientes para la resección intestinal. Del mismo modo, el tiempo transcurrido desde el inicio de las molestias hasta la cirugía y la presencia de intestino en la hernia son factores de riesgo independientes para las complicaciones del sitio quirúrgico. CONCLUSIÓN: Los pacientes que son operados después de las seis horas del inicio de las molestias y presentan comorbilidad son cirugías más complejas.


Assuntos
Parede Abdominal , Procedimentos Cirúrgicos do Sistema Digestório , Hérnia Abdominal , Parede Abdominal/cirurgia , Hérnia Abdominal/etiologia , Hérnia Abdominal/cirurgia , Herniorrafia , Humanos , Complicações Pós-Operatórias/epidemiologia , Complicações Pós-Operatórias/etiologia , Complicações Pós-Operatórias/cirurgia , Estudos Retrospectivos , Fatores de Risco
12.
Surg Radiol Anat ; 44(8): 1171-1180, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-35864247

RESUMO

PURPOSE: With the increased use of simulation-based training using animal models for the education of surgical and anaesthetic techniques, an increased understanding of the anatomy of such models and how they compare to humans is required. The transversus abdominis plane block is a regional anaesthetic technique that requires an understanding of the abdominal wall anatomy along with proficient ultrasound use. The current review aims to compare the anatomy of the abdominal wall across species, particularly focussing on the pertinent differences within the class of mammals, and secondarily, it aims to address the implications of these differences for the use of simulation-based training of the transversus abdominis plane block. METHODS: To achieve this, the PubMed, Web of Science and Google Scholar databases were searched for relevant literature. Studies pertaining to the musculature, vasculature or innervation of the anterolateral abdominal wall across species were included. RESULTS: The mammalian abdominal wall differs in its musculature, vasculature or innervation from that of amphibians, birds or reptiles; however, among species of mammals, the structure of the abdominal wall follows a similar framework. Particular differences among mammals include the additional muscular layer of the panniculus carnosus found in most mammals other than humans, the variable arterial origins and dominant vascular supply of the abdominal wall and the number of thoracolumbar nerves innervating the abdominal wall. CONCLUSION: When using animal models for simulation-based training, the pig is recommended for the transversus abdominis plane block given its closely homologous abdominal wall structure, availability and larger comparative size.


Assuntos
Parede Abdominal , Bloqueio Nervoso , Músculos Abdominais/inervação , Parede Abdominal/diagnóstico por imagem , Parede Abdominal/cirurgia , Animais , Humanos , Mamíferos , Bloqueio Nervoso/métodos , Suínos , Ultrassonografia
13.
Injury ; 53(9): 2988-2991, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-35853789

RESUMO

BACKGROUND: A seatbelt sign in patients with blunt abdominal injury is associated with both abdominal wall and intra-abdominal injuries. This study aimed to assess the association between signs of abdominal wall injury on computed tomography (CT) and rates of intra-abdominal injury in patients with a blunt abdominal injury and a clinical seatbelt sign. METHODS: This study includes hemodynamically stable trauma patients with blunt abdominal injury and a clinical seatbelt sign who were hospitalized in two regional trauma centers in Israel, during 2014-2019. All data were collected via the medical center's trauma registry in both centers. RESULTS: We identified 123 stable blunt abdominal trauma patients with a seatbelt sign, of which 101 (82.1%) and 22 (17.9%) had a low-grade and high-grade abdominal wall injury according to CT findings, respectively. Laparotomy rates were significantly higher in patients with signs of high-grade abdominal wall injury (p<0.0001). No differences in the timing of laparotomy between low and high-grade injuries were found. CONCLUSIONS: In stable patients with blunt abdominal trauma and a clinical seatbelt sign, the severity of abdominal wall injury, as represented by CT findings, may predict a need for surgical treatment.


Assuntos
Traumatismos Abdominais , Parede Abdominal , Ferimentos não Penetrantes , Traumatismos Abdominais/cirurgia , Parede Abdominal/diagnóstico por imagem , Humanos , Estudos Retrospectivos , Tomografia Computadorizada por Raios X , Ferimentos não Penetrantes/cirurgia
14.
Plast Reconstr Surg ; 150(3): 672-676, 2022 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-35789148

RESUMO

SUMMARY: Abdominal wall reconstruction represents a complex challenge for plastic surgeons, given the variable range of clinical situations requiring restoration of abdominal wall integrity. When significant myofascial defects are encountered, repair with either a synthetic or biological mesh is indicated, both of which have advantages and drawbacks. Taking inspiration from Gillies' fourth commandment of plastic surgery- Thou shalt not throw away a living thing -an innovative technique to obtain a vascularized autologous mesh from the tissues usually discarded during abdominal contouring procedures was conceived. The authors describe how to maximize the use of perforator flaps derived from abdominoplasty excision patterns in abdominal wall reconstruction to simultaneously obtain restoration of abdominal wall integrity and improvement of the abdominal contour.


Assuntos
Parede Abdominal , Abdominoplastia , Retalho Perfurante , Procedimentos Cirúrgicos Reconstrutivos , Cirurgia Plástica , Parede Abdominal/cirurgia , Abdominoplastia/métodos , Humanos , Retalho Perfurante/cirurgia , Próteses e Implantes , Procedimentos Cirúrgicos Reconstrutivos/métodos , Telas Cirúrgicas
15.
Int J Hyperthermia ; 39(1): 918-934, 2022 12.
Artigo em Inglês | MEDLINE | ID: mdl-35853611

RESUMO

BACKGROUND: PanDox is a Phase-1 trial of chemotherapeutic drug delivery to pancreatic tumors using ultrasound-mediated hyperthermia to release doxorubicin from thermally sensitive liposomes. This report describes trial-related hyperthermia simulations featuring: (i) new ultrasonic properties of human pancreatic tissues, (ii) abdomen deflections imposed by a water balloon, and (iii) respiration-driven organ motion. METHODS: Pancreas heating simulations were carried out using three patient body models. Pancreas acoustic properties were varied between values found in the literature and those determined from our human tissue study. Acoustic beam distortion was assessed with and without balloon-induced abdomen deformation. Target heating was assessed for static, normal respiratory, and jet-ventilation-controlled pancreas motion. RESULTS: Human pancreatic tumor attenuation is 63% of the literature values, so that pancreas treatments require commensurately higher input intensity to achieve adequate hyperthermia. Abdominal wall deformation decreased the peak field pressure by as much as 3.5 dB and refracted the focal spot by as much as 4.5 mm. These effects were thermally counteracted by sidelobe power deposition, so the net impact on achieving mild hyperthermia was small. Respiratory motion during moving beam hyperthermia produced localized regions overheated by more than 8.0 °C above the 4.0 °C volumetric goal. The use of jet ventilation reduced this excess to 0.7 °C and yielded temperature field uniformity that was nearly identical to having no respiratory motion. CONCLUSION: Realistic modeling of the ultrasonic propagation environment is critical to achieving adequate mild hyperthermia without the use of real time thermometry for targeted drug delivery in pancreatic cancer patients.


Assuntos
Parede Abdominal , Ablação por Ultrassom Focalizado de Alta Intensidade , Hipertermia Induzida , Neoplasias Pancreáticas , Acústica , Ensaios Clínicos Fase I como Assunto , Sistemas de Liberação de Medicamentos , Humanos , Hipertermia , Neoplasias Pancreáticas/diagnóstico por imagem , Neoplasias Pancreáticas/tratamento farmacológico
16.
Arq Gastroenterol ; 59(2): 226-230, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35830033

RESUMO

BACKGROUND: Poly-4-hydroxybutyrate (P4HB) is a naturally occurring polymer derived from transgenic E. coli bacteria with the longest degradation rate when compared to other available products. This polymer has been manufactured as a biosynthetic mesh to be used as reinforcement when repairing a variety of abdominal wall defects. OBJECTIVE: We aim to describe our center initial experience with this mesh and discuss the possible indications that may benefit from the use of P4HB mesh. METHODS: This is a descriptive retrospective study of patients who underwent abdominal wall repair with a P4HB mesh from October 2018 to December 2020 in a single, large volume, academic center. RESULTS: A total of 51 patients (mean age 54.4 years, range 12-89) underwent abdominal wall reconstruction with a P4HB mesh between October 2018 and December 2020. The mean BMI was 30.5 (range 17.2-50.6). Twenty-three (45%) patients had a prior hernia repair at the site. We grouped patients into six different indications for the use of P4HB mesh in our cohort: clean-contaminated, contaminated or infected field (57%), patient refusal for permanent meshes (14%), those with high risk for post-operative infection (12%), visceral protection of second mesh (10%), recurrence with related chronic pain from mesh (6%), and children (2%). Median follow-up was 105 days (range 8-648). Two patients had hernia recurrence (4%) and 8 (16%) patients developed seroma. CONCLUSION: P4HB mesh is a safe and a viable alternative for complex hernias and high-risk patients with a low complication rate in the short-term.


Assuntos
Parede Abdominal , Hérnia Ventral , Parede Abdominal/cirurgia , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Escherichia coli , Hérnia Ventral/cirurgia , Humanos , Hidroxibutiratos , Pessoa de Meia-Idade , Polímeros , Recidiva , Estudos Retrospectivos , Telas Cirúrgicas , Resultado do Tratamento , Adulto Jovem
17.
Andes Pediatr ; 93(1): 86-92, 2022 Feb.
Artigo em Espanhol | MEDLINE | ID: mdl-35856952

RESUMO

Abdominal wall pain, specifically ACNES syndrome (Anterior Cutaneous Nerve Entrapment Syn drome), is part of the differential diagnosis of chronic abdominal pain. This syndrome is frequently overlooked and therefore underdiagnosed. OBJECTIVES: To describe the clinical and evolutionary cha racteristics of patients diagnosed with ACNES and to draw attention to this pathology. PATIENTS AND METHOD: A retrospective descriptive study was carried out in a reference center, between October 2016 and July 2021, in patients under 17 years of age, diagnosed with ACNES, who met at least two of four of the following findings: Carnett's sign, Pinch test, dysesthesia at the point of maximum pain, improvement after infiltration of local anesthetic, having ruled out visceral or functional abdo minal pathology. Epidemiological variables, symptoms, physical examination, complementary tests, treatment, and evolution data were collected. Descriptive statistics were used. RESULTS: 20 patients diagnosed with ACNES, 75% women, median age 12.85 years. The abdominal examination revea led Carnett's sign in 95%, Pinch test sign in 65%, and dysesthesia in 90% of patients. 65% reported pseudovisceral symptoms. 7 patients were overweight or obese. The most frequent location (50%) was the right iliac fossa, at T10-T11 level. One patient reported spontaneous improvement; 7 impro ved with oral analgesia; 9 patients were referred to the pain unit, of which 5 attended, and improved with anesthetic infiltration with bupivacaine-triamcinolone. The remaining 4 were lost to follow-up. CONCLUSION: ACNES should be considered in patients with chronic pain. A combination of typical findings in medical history and physical examination allows its diagnosis, therefore, avoiding unne cessary complementary tests. A step-up treatment strategy should be applied, beginning with oral analgesia, followed by anesthetic infiltration, and, finally, anterior neurectomy.


Assuntos
Parede Abdominal , Acne Vulgar , Síndromes de Compressão Nervosa , Dor Abdominal/diagnóstico , Dor Abdominal/etiologia , Parede Abdominal/inervação , Criança , Feminino , Humanos , Masculino , Síndromes de Compressão Nervosa/diagnóstico , Parestesia , Estudos Retrospectivos
18.
Carbohydr Polym ; 291: 119577, 2022 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-35698395

RESUMO

Herein, hydroxypropyl chitosan azide (AZ-HPCTS) was synthesized and prepared as a hydrogel coating applied to a polypropylene mesh (PPM) through UV irradiation. This study confirmed the hypothesis that hydrogels with porous three-dimensional network structures exhibited excellent biocompatibility and biodegradability and adhered well to PPM. During the 180-day follow-up period, the AZ-HPCTS-coated PPM (AH-PPM) promoted wound healing by promoting the secretion of transforming growth factor-beta1 (TGF-beta1) in the acute reaction stage, which was reduced to a lower level at 30 d. The PPM exhibited a lower fibrin lysozyme activity based on the expression of tissue plasminogen activator (tPA) compared with that of AH-PPM (P < 0.05). The intraperitoneal adhesion score of AH-PPM decreased to 2.4 at 180 d in contrast with PPM (P < 0.01), which remained at a high level throughout the study. In conclusion, the AZ-HPCTS hydrogel is a potential coating for hernia patches that deserves further study in the biomaterial field.


Assuntos
Parede Abdominal , Quitosana , Parede Abdominal/cirurgia , Animais , Quitosana/química , Hérnia , Hidrogéis/química , Hidrogéis/farmacologia , Polipropilenos/química , Ratos , Telas Cirúrgicas , Ativador de Plasminogênio Tecidual
19.
Cutis ; 109(2): E6-E8, 2022 02.
Artigo em Inglês | MEDLINE | ID: mdl-35659811
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