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1.
J Craniomaxillofac Surg ; 42(7): 1260-4, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-24767802

RESUMO

OBJECTIVE: To investigate the difference of serological profile in pSS and their correlation with the clinical characteristics of parotid glands. METHODS: This retrospective study includes 289 patients who fulfilled the 2002 American-European Consensus Group Criteria for pSS. The patients were categorized by the clinical features of parotid glands: Group 1 (massive group), Group 2 (infection group), Group 3 (swelling group) and Group 4 (others). The demographic data and serological profiles among these groups were compared. Statistical analyses of the results between groups were performed using the Student t test, Fisher's exact test, chi-square and analysis of variance. RESULTS: There was a difference of serological profile in the different clinical characteristics of parotid glands of pSS. Serum Ig G value of Group 1 was the greatest, and complement C4 was lowest in the four groups. Serum Ig E value of Group 2 was the greatest and ESR of Group 3 was the greatest in the four groups. CONCLUSION: This study has determined the differences of serological profile in the different clinical features of parotid glands of pSS patients, which may help advance our understanding of the disease and improve patient management.


Assuntos
Glândula Parótida/patologia , Síndrome de Sjogren/sangue , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Autoantígenos/sangue , Sedimentação Sanguínea , Proteína C-Reativa/análise , Complemento C3/análise , Complemento C4/análise , Contagem de Eritrócitos , Feminino , Seguimentos , Hemoglobinas/análise , Humanos , Imunoglobulina E/sangue , Imunoglobulina G/sangue , Contagem de Linfócitos , Masculino , Pessoa de Meia-Idade , Monócitos/patologia , Parotidite/sangue , Parotidite/microbiologia , Estudos Retrospectivos , Ribonucleoproteínas/sangue , Síndrome de Sjogren/patologia , Adulto Jovem , Microglobulina beta-2/sangue
2.
Acta Paediatr ; 102(2): 177-81, 2013 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-22924783

RESUMO

AIM: To characterize the features of juvenile parotitis in a prospective setup and epidemiology. METHODS: All children with parotitis admitted to Helsinki University Central Hospital 2005-2010 were recruited. Clinical characteristics, given treatment, outcome, blood leukocyte count, C-reactive protein, serum amylase and trypsinogen, SPINK-1 genotype and mumps antibodies were recorded. To map the epidemiology, a questionnaire was sent to 1000 randomly selected 13-year-old children. RESULTS: The prospective study included 41 children (aged ≤ 17) with acute parotitis, all in good general condition. Serum amylase, but not trypsinogen, was elevated in majority of the cases (79%) and C-reactive protein in 68%. Eleven (27%) children had an elevated blood leukocyte count. None had acute mumps. Most children recovered well, 51% being treated symptomatically only. Seven children were treated on ward. Seventeen (46%) children had recurrent symptoms. One child (2.4%) had SPINK P55S mutation. According to the epidemiological questionnaire, 1.1% of the respondents (8/728, response rate 73%) reported a verified episode(s) of parotitis. CONCLUSION: Juvenile parotitis has a frequency close to 1%. In the majority, the general condition is good during the episode. Serum amylase serves as an additional marker for the disease. Parotitis has a tendency to recur in almost half of the cases.


Assuntos
Parotidite , Doença Aguda , Adolescente , Amilases/sangue , Anticorpos Antivirais/sangue , Biomarcadores/sangue , Criança , Pré-Escolar , Feminino , Finlândia/epidemiologia , Seguimentos , Inquéritos Epidemiológicos , Humanos , Contagem de Leucócitos , Masculino , Vírus da Caxumba/imunologia , Parotidite/sangue , Parotidite/diagnóstico , Parotidite/epidemiologia , Parotidite/terapia , Estudos Prospectivos , Inquéritos e Questionários
3.
Int J Hematol ; 83(1): 86-91, 2006 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-16443559

RESUMO

This study evaluated patients for the influence of the dose rate and lung dose of fractionated total body irradiation (TBI) in preparation for allogeneic bone marrow transplantation (BMT) on the subsequent development of interstitial pneumonitis (IP). Sixty-six patients at our institute were treated with TBI followed by BMT. All of the patients received a total TBI dose of 12 Gy given in 6 fractions over 3 days and were divided into 3 groups according to the radiation dose rate and lung dose: group A, lung dose of 8 Gy (n = 18); group B, lung dose of 12 Gy at 8 cGy/min (n = 25); and group C, lung dose of 12 Gy at 19 cGy/min (n = 23). The overall survival rate, the cumulative incidence of relapse, and the cumulative incidence of IP were evaluated in relation to various potential indicators of future IP. There were no significant differences in survival and relapse rates between patient group A and combined groups B and C. Clinically significant IP occurred in 13 patients. The cumulative incidence of IP was significantly higher in patients who developed acute parotitis as indicated by either an elevation in the serum amylase level or parotid pain of grade 1 to 2. There was no difference in IP incidence among groups A, B, and C. There was no significant difference in IP incidence between lung dose values of 8 Gy (with lung shielding) and 12 Gy (without lung shielding) and between dose rate values of 8 cGy/min and 19 cGy/ min, at least when TBI was given in 6 fractions. The presence of acute parotitis during or just after TBI may be a predictor of IP.


Assuntos
Fracionamento da Dose de Radiação , Doenças Pulmonares Intersticiais/etiologia , Parotidite , Irradiação Corporal Total/efeitos adversos , Adolescente , Adulto , Amilases/sangue , Transplante de Medula Óssea/efeitos adversos , Transplante de Medula Óssea/métodos , Transplante de Medula Óssea/mortalidade , Criança , Pré-Escolar , Relação Dose-Resposta à Radiação , Feminino , Doenças Hematológicas/complicações , Doenças Hematológicas/mortalidade , Doenças Hematológicas/terapia , Humanos , Incidência , Doenças Pulmonares Intersticiais/sangue , Doenças Pulmonares Intersticiais/mortalidade , Masculino , Pessoa de Meia-Idade , Parotidite/sangue , Parotidite/etiologia , Parotidite/mortalidade , Estudos Retrospectivos , Taxa de Sobrevida , Transplante Homólogo , Irradiação Corporal Total/métodos , Irradiação Corporal Total/mortalidade
4.
Pediatr Allergy Immunol ; 15(3): 281-3, 2004 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-15209964

RESUMO

Recurrent parotitis is an uncommon condition in children. In most cases the etiology is unknown, although the disease is occasionally associated with viral infections, autoimmune disorders and immunodeficiency. We describe, for the first time, a child with recurrent parotitis and isolated immunoglobulin A (IgA) deficiency, without autoimmune disease. As IgA is the main immunoglobulin secreted into the mucosal surfaces, including that of the respiratory and gastrointestinal tracts, and into the saliva, the lack of IgA may be involved in the pathogenesis of recurrent parotitis. We recommend that IgA and other immunoglobulins be tested in all cases of recurrent parotitis.


Assuntos
Deficiência de IgA/imunologia , Parotidite/imunologia , Criança , Humanos , Imunoglobulina A/sangue , Masculino , Parotidite/sangue , Parotidite/prevenção & controle , Recidiva
5.
J Med Virol ; 70(3): 459-62, 2003 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-12767011

RESUMO

Infantile chronic recurrent parotitis (ICRP) has been attributed to multiple causes, including viral infections, and therefore its treatment remains empirical. Our aim was to evaluate the involvement of respiratory and oropharyngeal viruses in acute episodes of ICRP. Seventy children were studied, 50 patients and 20 age-matched controls, in a 2-year follow-up study. Saliva samples were taken from the parotid duct and analyzed by viral isolation and immunofluorescence for adenovirus (Ad), respiratory sincitial virus (RSV), parainfluenza virus (PI), influenza virus (Flu), Cytomegalovirus (CMV), and herpes simplex virus (HSV). Paired sera samples were tested by ELISA for anti-Epstein-Barr virus (EBV) IgG and anti-mumps IgM and IgG. Viral infections were detected in 7/50 (14%) cases of the ICRP group: one CMV; 2 Enteroviruses isolated in human embryonic lung fibroblast cells; 1 Flu A; and 3 mumps virus. No EBV seroconversions were detected. In the control group, 2 out of the 20 children had an asymptomatic mumps positive IgM titer. Our data indicate that the main respiratory and oropharyngeal viruses are not the cause of acute episodes of ICRP in Chilean children.


Assuntos
Parotidite/virologia , Saliva/virologia , Criança , Pré-Escolar , Chile/epidemiologia , Doença Crônica , Citomegalovirus/isolamento & purificação , Enterovirus/isolamento & purificação , Ensaio de Imunoadsorção Enzimática , Feminino , Imunofluorescência , Humanos , Lactente , Masculino , Vírus da Caxumba/isolamento & purificação , Parotidite/sangue , Parotidite/epidemiologia , Parotidite/patologia , Recidiva
7.
Arch Inst Pasteur Alger ; 62: 216-24, 1998.
Artigo em Francês | MEDLINE | ID: mdl-11256311

RESUMO

Virus specific IgM antibodies are very useful for the diagnosis of primer infection by the rubella and parotidis viruses. ELISA is the method usually used to detect IgM antibodies. The reactives and in some laboratories the apparatus are not always available. We carried out a serological method based on the immunocapture inhibition of hemagglutination of theses viruses by positive sera. 39 sera and 80 sera collected from patients and healthy population have been respectively studied to detect antirubella and antiparotidis IgM. The test appeared as sensitive and specific as the immunocapture IgM ELISA.


Assuntos
Parotidite/diagnóstico , Parotidite/imunologia , Rubéola (Sarampo Alemão)/diagnóstico , Rubéola (Sarampo Alemão)/imunologia , Adulto , Criança , Feminino , Testes de Hemaglutinação , Humanos , Imunoglobulina M/sangue , Masculino , Parotidite/sangue , Rubéola (Sarampo Alemão)/sangue
8.
Stomatologiia (Mosk) ; 74(3): 38-40, 1995.
Artigo em Russo | MEDLINE | ID: mdl-7570696

RESUMO

Activities of glucose-6-phosphate dehydrogenase (G-6-PDH) and malate dehydrogenase were measured in the blood of 38 patients with acute nonepidemic parotitis and the status of glutathione antioxidant system assessed. The predominance of free-radical processes in the mechanisms of impairment of the parotid gland was confirmed. Increased level of lipid peroxidation products and decompensation of glutathione antioxidant system were found to be due to incompetence of the malate shuttle and low activity of G-6-PDH. A conclusion is made about the necessity of revising current approaches to prevention and therapy of acute nonepidemic parotitis.


Assuntos
Antioxidantes , Glutationa/sangue , Parotidite/sangue , Doença Aguda , Adolescente , Adulto , Idoso , Feminino , Glucosefosfato Desidrogenase/sangue , Humanos , Peroxidação de Lipídeos , Masculino , Malondialdeído/sangue , Pessoa de Meia-Idade , Pancreatite/sangue
9.
Stomatologiia (Mosk) ; 73(2): 40-2, 1994.
Artigo em Russo | MEDLINE | ID: mdl-9612048

RESUMO

Blood levels of lipid peroxidation products, glutathion enzymatic and nonenzymatic antioxidants were measured in 58 patients with parotid gland involvement in acute surgical diseases of the abdominal organs. The authors prove the predominance of free-radical processes in the mechanisms of cellular injury initiated by inflammation mediators and proteolytic enzymes. A conclusion is made on the necessity of altering the methods of prevention and therapy of acute postoperative parotitis.


Assuntos
Abdome/cirurgia , Peroxidação de Lipídeos , Parotidite/etiologia , Complicações Pós-Operatórias/etiologia , Doença Aguda , Adolescente , Adulto , Idoso , Feminino , Radicais Livres/sangue , Glutationa/sangue , Humanos , Masculino , Malondialdeído/sangue , Pessoa de Meia-Idade , Parotidite/sangue , Complicações Pós-Operatórias/sangue
10.
Bone Marrow Transplant ; 6(4): 259-61, 1990 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-1707701

RESUMO

Etoposide is an important component of several intensive therapy regimens in allogeneic and autologous bone marrow transplantation for advanced hematologic malignancies. We observed the occurrence of transient acute parotid and submandibular sialoadenitis in nine of 19 patients receiving high dose etoposide and melphalan followed by autologous bone marrow rescue. Manifestations included pain, tenderness and swelling of the parotid and submandibular glands. Symptoms arose 4-16 h after completion of etoposide infusion and resolved within 72 h. Elevation of serum amylase accompanied the symptoms, and was also observed in some patients who were asymptomatic. Discomfort was controlled with analgesics and the clinical course was uncomplicated in all cases. Transient parotitis is a relatively frequent and benign complication of high dose etoposide therapy.


Assuntos
Transplante de Medula Óssea , Etoposídeo/uso terapêutico , Parotidite/tratamento farmacológico , Doença Aguda , Adulto , Amilases/sangue , Relação Dose-Resposta a Droga , Etoposídeo/efeitos adversos , Feminino , Humanos , Masculino , Melfalan/uso terapêutico , Parotidite/sangue , Parotidite/cirurgia
12.
Arch Otorhinolaryngol ; 242(3): 321-8, 1985.
Artigo em Inglês | MEDLINE | ID: mdl-2416305

RESUMO

The release of glandular kallikrein into the interstitium of the parotid gland appears to play an important role in the occurrence of the inflammatory interstitial edema in chronic recurrent parotitis. This provides fresh impetus for the treatment of this parotid disease with a kallikrein inhibitor. In our present study, seven patients with acute exacerbated chronic recurrent parotitis were treated with the kallikrein inhibitor aprotinin (Trasylol, Bayer AG, Leverkusen). With this therapy all patients were free of pain 12 h after the start of the therapy and most salivary gland function had returned to normal by 48 h after beginning treatment. Within this period of time, concomitant swelling of the affected parotid gland disappeared completely in five patients and resolved in the other two patients after 1 week.


Assuntos
Aprotinina/uso terapêutico , Parotidite/tratamento farmacológico , Aprotinina/sangue , Doença Crônica , Avaliação de Medicamentos , Glucose-6-Fosfato Isomerase/metabolismo , Humanos , Calicreínas/metabolismo , Glândula Parótida/metabolismo , Parotidite/sangue , Recidiva , Saliva/metabolismo
14.
Am J Physiol ; 228(3): 730-3, 1975 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-46723

RESUMO

Alpha-M-fetoprotein (AMFP) was detected in the serum of rats subjected to intraoral manipulations, i.e., instillations into the parotid gland and injections into the gingival mucosa of saline or foreign proteins. The identity of AMFP with acute-phase protein is pointed out.


Assuntos
alfa-Globulinas/sangue , Proteínas Fetais/sangue , Gengivite/sangue , Parotidite/sangue , Anestesia Geral , Animais , Feminino , Imunodifusão , Masculino , Métodos , Pentobarbital/farmacologia , Ratos
18.
Rio de Janeiro; s.n; 06 nov. 1916. 118 p. ilus, tab.
Tese em Português | Coleciona SUS, IMNS | ID: biblio-923311
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