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1.
An. Fac. Cienc. Méd. (Asunción) ; 53(2): 157-164, 20200800.
Artigo em Espanhol | LILACS | ID: biblio-1119713

RESUMO

Introducción: La neurofibromatosis (NF) se caracteriza por ser una anormalidad ectodérmica con formación de múltiples neurofibromas en todo el cuerpo. La forma más frecuente es la NF1, que se presenta con manifestaciones variables. El tumor maligno de la vaina del nervio periférico (TMVNP) es una de las formaciones tumorales que se puede ver en el contexto de esta patología. El papel de la radiología es el de caracterizar la lesión y su invasión, así como el de valorar la presencia de otras lesiones tumorales. Caso clínico: Paciente adulto, masculino, portador de Neurofibromatosis tipo I y hemorroides, acudió por hemorragia digestiva por lo que se realizó una endoscopía donde se encontró una lesión estenosante prepilórica. Se solicitó un barrido tomográfico donde se identificaron lesiones de aspecto benigno en hígado, ambas suprarrenales y una lesión tumoral de aspecto maligno en la parrilla costal izquierda. Discusión: Un avezado conocimiento de la patología con los hallazgos radiológicos que se suelen observar en estos pacientes, son de suma importancia para que el médico radiólogo pueda conocer la localización de las lesiones, tanto las clásicas como las no habituales, y orientar entre una lesión de carácter benigno con otras de carácter maligno.


Introduction: Introduction: Neurofibromatosis (NF) is characterized by ectodermal abnormality with the presence of multiple neurofibromas throughout the body. The most common form is NF1, which occurs with variable manifestations. Malignant neurilemmoma or peripheral nerve sheath malignant tumor (PNSMT) is one of the tumor formations that can be seen in the context of this pathology. The role of radiology is to characterize the injury and its invasion, as well as to assess the presence of other tumor lesions. Case report: Adult male patient, carrier of Neurofibromatosis type I and hemorrhoids, presented with digestive hemorrhage, so an endoscopy was performed where a prepyloric stenosing lesion was found. A tomographic scan was requested where benign-looking lesions were identified in the liver, both adrenal glands, also a malignant-looking tumor lesion on the left rib cage. Conclusion: An experienced knowledge of the pathology with the radiological findings that are usually observed in these patients are of utmost importance so that the radiologist can know the location of the lesions, both classic and unusual, and orient between a character injury benign with others of malignant character.


Assuntos
Neurofibromatose 1/diagnóstico por imagem , Patologia , Nervos Periféricos
2.
Acta Med Hist Adriat ; 18(1): 27-46, 2020 06.
Artigo em Inglês | MEDLINE | ID: mdl-32638598

RESUMO

The article is the first step of a research project aimed at investigating new perspectives and aspects of Morgagni's role and work. His activities as a medical examiner and forensic doctor are yet to be truly discovered. Manuscripts, written by Morgagni when he was a forensic expert for the Health Magistrate of Venice, currently preserved at the City Library in Forli (Italy), shed light on a new aspect of his cultural background. As a forensic doctor, he also helped push an increase in "social medicine" in Italy, when physicians began to collaborate with the administrative and political institutions in order to plan environmental and urban regulations to control air quality. While reading his reports, his contribution to the primordial medical Hygiene and Public Health emerges. Among his reports, the authors focused on the one concerning the Beatification of Gregorio Barbarigo, which clearly highlights his pathological approach, as well as his knowledge and application of embalming systems and mummiology. Moreover, this report could be considered as an issue in the history of paleopathology.


Assuntos
Catolicismo/história , Medicina Legal/história , Patologia/história , Santos/história , Anatomia/história , Exumação/história , História do Século XVII , História do Século XVIII , História do Século XIX , História do Século XX , Humanos , Itália , Múmias/história , Odorantes
3.
Cuad. Hosp. Clín ; 61(1): [9], jul. 2020. ilus.
Artigo em Espanhol | LILACS, LIBOCS | ID: biblio-1118905

RESUMO

OBJETIVO: informar acerca de un caso de endocarditis bacteriana. Paciente varón de 34 años de edad, con único antecedente de rinitis alérgica con tratamiento irregular. Él es procedente de Valparaiso Chile, se encuentra en sus vacaciones en la ciudad de La Paz, acude al servicio de medicina interna ­ emergencias, con clínica compatible con edema agudo de pulmón de la altura y edema cerebral de la altura, asociado a sepsis de foco pulmonar, que progresa a choque séptico, durante su internación intercurre con alzas térmicas continuas, asociado a hallazgo ecocardiográfico de vegetación en ventrículo derecho con hemocultivo positivo, por lo que se llega al diagnóstico de endocarditis bacteriana, se realizó el tratamiento correspondiente, y resolución del cuadro.


OBJECTIVE: to report a case of bacterial endocarditis A 34-year-old male patient with a unique history of allergic rhinitis with irregular treatment. He comes from Valparaiso Chile, is on vacation in the city of La Paz, goes to the service of internal medicine - emergencies with compatible clinical with acute pulmonary edema of height and cerebral edema of height, associated with sepsis of focus pulmonary disease, which progresses to septic shock, during internment with continuous hyperthermia, associated vegetation in right ventricle for echocardiography, also positive blood culture, so that a diagnosis of bacterial endocarditis is reached, Corresponding treatment was carried out, and resolution of pathology..


Assuntos
Masculino , Adulto , Edema Pulmonar , Choque Séptico , Endocardite Bacteriana , Patologia , Ecocardiografia , Pulmão
4.
Cuad. Hosp. Clín ; 61(1): [12], jul. 2020. ilus.
Artigo em Espanhol | LILACS, LIBOCS | ID: biblio-1118976

RESUMO

PROPÓSITO: este artículo se realizó para contribuir con la difusión del conocimiento sobre el COVID-19 en la lengua hispana. HALLAZGOS: el SARS-CoV-2 fue descubierto en diciembre del 2019 y se difundió mundialmente desde entonces; el 11 de marzo de 2020 la OMS declaró globalmente estado de pandemia. Mientras fue incrementando la gravedad y frecuencia del COVID-19 en el mundo, la comunidad científica trabajó arduamente produciendo evidencia capaz de dilucidar los detalles de esta patología. Esta serie de artículos pretende agregar información lo más actualizada posible, interpretándola y adaptándola a la realidad boliviana. SUMARIO: la elaboración de este artículo está basado en información conocida sobre la historia de la aparición de esta nueva enfermedad e información vigente y actualizada sobre las características fisiopatológicas descritas en la literatura mundial


Assuntos
Doença , Infecções por Coronavirus , História , Patologia , Informação , Literatura
6.
Klin Monbl Augenheilkd ; 237(7): 860-866, 2020 Jul.
Artigo em Inglês, Alemão | MEDLINE | ID: mdl-32659839

RESUMO

The high-throughput method of "Next Generation Sequencing" (NGS) allows cost-effective decoding of the nucleotide sequences of millions of RNA molecules in a sample. This makes it possible to determine the number of distinct RNA molecules in tissues or cells and to use these data to draw conclusions. The entirety of RNAs, in particular mRNAs (messenger RNAs) as potential precursors of proteins, provides a comprehensive insight into the functional state of the cells and tissues under investigation. In addition to cell cultures or unfixed tissue, formalin-fixed and paraffin-embedded (FFPE) tissue can also be analysed for this purpose using specific methods. In this overview, the methodological strategy and its application to the field of ophthalmic histopathology are presented.


Assuntos
Formaldeído , Sequenciamento de Nucleotídeos em Larga Escala , Sequência de Bases , Humanos , Oftalmologia , Inclusão em Parafina , Patologia , Análise de Sequência de RNA , Manejo de Espécimes
7.
Zhonghua Bing Li Xue Za Zhi ; 49(7): 667-669, 2020 Jul 08.
Artigo em Chinês | MEDLINE | ID: mdl-32610375

Assuntos
Patologia , China
11.
Arch Pathol Lab Med ; 144(9): 1027-1036, 2020 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-32364793

RESUMO

The ongoing global pandemic of coronavirus disease 2019 (COVID-19) has rapidly disrupted traditional modes of operation in health care and education. In March 2020, institutions in the United States began to implement a range of policies to discourage direct contact and encourage social distancing. These measures have placed us in an unprecedented position where education can no longer occur at close quarters-most notably, around a multiheaded microscope-but must instead continue at a distance. This guide is intended to be a resource for pathologists and pathologists-in-training who wish to leverage technology to continue collaboration, teaching, and education in this era. The article is focused mainly on anatomic pathology; however, the technologies easily lend themselves to clinical pathology education as well. Our aim is to provide curated lists of various online resources that can be used for virtual learning in pathology, provide tips and tricks, and share our personal experience with these technologies. The lists include videoconferencing platforms; pathology Web sites; free online educational resources, including social media; and whole slide imaging collections. We are currently living through a unique situation without a precedent or guidebook, and we hope that this guide will enable the community of pathology educators worldwide to embrace the opportunities that 21st century technology provides.


Assuntos
Betacoronavirus , Infecções por Coronavirus/prevenção & controle , Educação a Distância/métodos , Educação de Pós-Graduação em Medicina/métodos , Pandemias/prevenção & controle , Patologia/educação , Pneumonia Viral/prevenção & controle , Humanos , Estados Unidos
14.
Med J Aust ; 212(8): 377-382, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-32304240

RESUMO

OBJECTIVES: To estimate the carbon footprint of five common hospital pathology tests: full blood examination; urea and electrolyte levels; coagulation profile; C-reactive protein concentration; and arterial blood gases. DESIGN, SETTING: Prospective life cycle assessment of five pathology tests in two university-affiliated health services in Melbourne. We included all consumables and associated waste for venepuncture and laboratory analyses, and electricity and water use for laboratory analyses. MAIN OUTCOME MEASURE: Greenhouse gas footprint, measured in carbon dioxide equivalent (CO2 e) emissions. RESULTS: CO2 e emissions for haematology tests were 82 g/test (95% CI, 73-91 g/test) for coagulation profile and 116 g/test (95% CI, 101-135 g/test) for full blood examination. CO2 e emissions for biochemical tests were 0.5 g/test CO2 e (95% CI, 0.4-0.6 g/test) for C-reactive protein (low because typically ordered with urea and electrolyte assessment), 49 g/test (95% CI, 45-53 g/test) for arterial blood gas assessment, and 99 g/test (95% CI, 84-113 g/test) for urea and electrolyte assessment. Most CO2 e emissions were associated with sample collection (range, 60% for full blood examination to 95% for coagulation profile); emissions attributable to laboratory reagents and power use were much smaller. CONCLUSION: The carbon footprint of common pathology tests was dominated by those of sample collection and phlebotomy. Although the carbon footprints were small, millions of tests are performed each year in Australia, and reducing unnecessary testing will be the most effective approach to reducing the carbon footprint of pathology. Together with the detrimental health and economic effects of unnecessary testing, our environmental findings should further motivate clinicians to test wisely.


Assuntos
Pegada de Carbono , Patologia , Austrália , Humanos , Flebotomia , Manejo de Espécimes
15.
Pathologe ; 41(3): 294-295, 2020 05.
Artigo em Alemão | MEDLINE | ID: mdl-32342205
16.
Rev Med Suisse ; 16(688): 618-621, 2020 Apr 01.
Artigo em Francês | MEDLINE | ID: mdl-32239834

RESUMO

Recent progress in molecular engineering, digital imaging and artificial intelligence improve human modern medicine to levels never seen before. Digital pathology becomes the new standard of patient care in dermatology and personalized medicine. It is increasingly used for digital exchange of histological slides, personalized consultations, tumor boards, quantitative image analysis for research purposes and in education. Digital pathology allows automatization and quantification with greater consistency and accuracy than light microscopy. Personalized dermatology is focusing on tailoring therapy to the individual characteristics of each patient and allow to use genetic information in order to develop a treatment plan, uniquely suited to each patient, which in turn leads to improved quality of care and management of each individual.


Assuntos
Dermatologia/métodos , Patologia/métodos , Inteligência Artificial , Computadores , Dermatologistas , Humanos
17.
Klin Monbl Augenheilkd ; 237(7): 856-859, 2020 Jul.
Artigo em Alemão | MEDLINE | ID: mdl-32289848

RESUMO

INTRODUCTION: Deep learning has received increasing attention in recent years and is used in many different areas. Since image analysis is a strength of deep learning, it would be obvious to use it for histopathological questions too. Our goal is to identify possible deep learning approaches from general pathology which could be used in ophthalmic pathology. In addition, the data of the past year will be used to estimate the proportion of potentially interesting cases and the necessary technical effort. METHODS: Firstly, a literature search for deep learning models and their possible applications in the field of pathology was carried out. In order to estimate the potential benefit, technical challenges and feasibility, the number of suitable ophthalmopathology cases in our lab in 2019 for the identified models was determined and put in relation to the resulting amount of data and the scanning time. RESULTS: We identified 7 areas of particular interest: determination of regions of interest (ROI), classification of histological images in scoring systems, mapping of tumor fractions, differentiation of different types of inflammation, differentiation of various cutaneous tumors, classification of lymphomas and prediction of patient outcome-based on tumor histology. Within one year, a total of 831 cases (43%) would have been suitable for the above models. The creation of whole slide images (WSI) for all histological cases would have required a storage capacity of 630 GB with a scanning time of 35 h. CONCLUSION: There are several deep learning approaches which are also interesting for ophthalmic pathology. Most of them would have to be specially trained for the ophthalmopathological aspects. To be able to apply deep learning approaches, it is necessary to have a good IT infrastructure with the possibility to create and permanently store WSI, and this seems to be technically feasible. Future studies should focus on the specific practical implementation of current deep learning possibilities for ophthalmic pathology.


Assuntos
Aprendizado Profundo , Técnicas Histológicas , Patologia , Previsões , Humanos
18.
Nat Protoc ; 15(5): 1649-1672, 2020 05.
Artigo em Inglês | MEDLINE | ID: mdl-32238952

RESUMO

In pathology, microscopy is an important tool for the analysis of human tissues, both for the scientific study of disease states and for diagnosis. However, the microscopes commonly used in pathology are limited in resolution by diffraction. Recently, we discovered that it was possible, through a chemical process, to isotropically expand preserved cells and tissues by 4-5× in linear dimension. We call this process expansion microscopy (ExM). ExM enables nanoscale resolution imaging on conventional microscopes. Here we describe protocols for the simple and effective physical expansion of a variety of human tissues and clinical specimens, including paraffin-embedded, fresh frozen and chemically stained human tissues. These protocols require only inexpensive, commercially available reagents and hardware commonly found in a routine pathology laboratory. Our protocols are written for researchers and pathologists experienced in conventional fluorescence microscopy. The conventional protocol, expansion pathology, can be completed in ~1 d with immunostained tissue sections and 2 d with unstained specimens. We also include a new, fast variant, rapid expansion pathology, that can be performed on <5-µm-thick tissue sections, taking <4 h with immunostained tissue sections and <8 h with unstained specimens.


Assuntos
Resinas Acrílicas , Hidrogéis/síntese química , Microscopia de Fluorescência/métodos , Nanotecnologia/métodos , Patologia/métodos , Humanos
19.
Am J Clin Pathol ; 153(4): 449-469, 2020 03 09.
Artigo em Inglês | MEDLINE | ID: mdl-32080717

RESUMO

OBJECTIVES: The study explored job stress, burnout, work-life balance, well-being, and job satisfaction among pathology residents and fellows. The aims were to examine the prevalence and sources of stress and burnout, as well as identify resources to promote work-life balance and well-being and prevent burnout. METHODS: The study used a cross-sectional survey deployed online to a large national sample of pathology residents and fellows. RESULTS: Job stress and burnout were prevalent, with more than a third of the respondents reporting that they were currently experiencing burnout. The respondents, particularly residents, were struggling with academics, and higher percentages were struggling with work-life balance and emotional well-being. Overall, the majority of respondents who rated their work-life balance indicated that it was poor or fair. Among the factors contributing to job stress and burnout and detracting from work-life balance, workload was the leading factor. CONCLUSIONS: The factors contributing to job stress and burnout included organizational factors such as workload, value, and aspects of the learning environment, as well as personal factors such as work-life integration. One of the overarching implications is the need to address a range of interdependent considerations in designing resources to reduce job stress, promote work-life balance, and prevent burnout.


Assuntos
Esgotamento Profissional/psicologia , Satisfação no Emprego , Estresse Ocupacional/psicologia , Patologistas/psicologia , Equilíbrio Trabalho-Vida , Adulto , Estudos Transversais , Bolsas de Estudo , Feminino , Humanos , Internato e Residência , Masculino , Patologia , Inquéritos e Questionários
20.
Arch Pathol Lab Med ; 144(3): 275-276, 2020 03.
Artigo em Inglês | MEDLINE | ID: mdl-32101057

RESUMO

This special section includes 4 articles as the proceedings of the Fifth Princeton Integrated Pathology Symposium (PIPS): Genitourinary Pathology, and an update on neuroendocrine tumor of the prostate. The symposium took place at the Princeton Medical Center, Plainsboro, New Jersey, on Sunday April 15, 2018. We hope again that this collection of outstanding reviews will serve as a handy reference for your daily practice.


Assuntos
Patologia/métodos , Próstata/patologia , Neoplasias da Próstata/patologia , Humanos , Masculino , Patologia Clínica/métodos , Patologia Molecular/métodos , Patologia Cirúrgica/métodos , Próstata/metabolismo , Próstata/cirurgia , Neoplasias da Próstata/genética , Neoplasias da Próstata/cirurgia
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