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1.
Cell Prolif ; 53(11): e12916, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-33058377

RESUMO

Healing after mammalian skin injury involves the interaction between numerous cellular constituents and regulatory factors, which together form three overlapping phases: an inflammatory response, a proliferation phase and a remodelling phase. Any slight variation in these three stages can substantially alter the healing process and resultant production of scars. Of particular significance are the mechanisms responsible for the scar-free phenomenon observed in the foetus. Uncovering such mechanisms would offer great expectations in the treatment of scars and therefore represents an important area of investigation. In this review, we provide a comprehensive summary of studies on injury-induced skin regeneration within the foetus. The information contained in these studies provides an opportunity for new insights into the treatment of clinical scars based on the cellular and molecular processes involved.


Assuntos
Cicatriz/fisiopatologia , Pele/fisiopatologia , Cicatrização , Adulto , Animais , Cicatriz/patologia , Feto/patologia , Feto/fisiopatologia , Fibroblastos/patologia , Humanos , Queratinócitos/patologia , Lesões Pré-Natais/patologia , Lesões Pré-Natais/fisiopatologia , Pele/embriologia , Pele/lesões , Pele/patologia
2.
Khirurgiia (Mosk) ; (10): 79-87, 2020.
Artigo em Russo | MEDLINE | ID: mdl-33047590

RESUMO

Active collagen type I successfully used in regenerative medicine. However, despite the large amount of material of cellular and molecular mechanisms underlying skin repair, the molecular mechanisms of wound healing with use collagen type I, not studied enough. PURPOSE OF THE STUDY: To study the mechanism of the native collagen type I wound-healing action of native type I collagen on the example of the medical device Collost (7% gel) in a model of the rats difficult-to-heal skin wounds. MATERIAL AND METHODS: Male rats in population SD (72 individuals) surgically formed an ischemic dorsal skin flap (3×10 cm) with two full-thickness skin wounds 6 mm in diameter.The trained animals divided into 2 groups: in the experimental group, medical device Collost (gel) applied once after the operation, in the control group - a standard medical device for comparison. The dynamics of wound healing assessed, the number of M2 macrophages, myofibroblasts, vascularization and expression of the main markers of the repair process in the wound tissues and time points for assessment were: after 3, 7 and 14 days after operation using macroscopic, immunohistochemical, and molecular methods. RESULTS: It has been established that the mechanism of action of native collagen type I is associated with the acceleration of the appearance of «progenitorous¼ M2-macrophages in the wound tissues, decrease in the severity of inflammation or reduction in the duration of the inflammatory stage of the repair process, change in the expression spectrum of number of growth factors, an acceleration of neovasculogenesis. CONCLUSION: In this work, on the modern experimental model shown regenerative efficiency of a medical device based on collagen type I and described the molecular and cellular processes of wound healing when using it It has been shown that the acceleration of wound healing processes occurs when using a medical device based on native collagen type 1, it is also accompanied by a better aesthetic closure of the damaged skin area.


Assuntos
Colágeno Tipo I/administração & dosagem , Fármacos Dermatológicos/administração & dosagem , Pele/efeitos dos fármacos , Lesões dos Tecidos Moles/tratamento farmacológico , Cicatrização/fisiologia , Animais , Materiais Biocompatíveis/administração & dosagem , Modelos Animais de Doenças , Géis , Isquemia/tratamento farmacológico , Masculino , Ratos , Pele/lesões , Lesões dos Tecidos Moles/terapia , Retalhos Cirúrgicos/irrigação sanguínea
3.
PLoS One ; 15(9): e0239363, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32970710

RESUMO

BACKGROUND: Healthcare workers around the world are experiencing skin injury due to the extended use of personal protective equipment (PPE) during the COVID-19 pandemic. These injuries are the result of high shear stresses acting on the skin, caused by friction with the PPE. This study aims to provide a practical lubricating solution for frontline medical staff working a 4+ hours shift wearing PPE. METHODS: A literature review into skin friction and skin lubrication was conducted to identify products and substances that can reduce friction. We evaluated the lubricating performance of commercially available products in vivo using a custom-built tribometer. FINDINGS: Most lubricants provide a strong initial friction reduction, but only few products provide lubrication that lasts for four hours. The response of skin to friction is a complex interplay between the lubricating properties and durability of the film deposited on the surface and the response of skin to the lubricating substance, which include epidermal absorption, occlusion, and water retention. INTERPRETATION: Talcum powder, a petrolatum-lanolin mixture, and a coconut oil-cocoa butter-beeswax mixture showed excellent long-lasting low friction. Moisturising the skin results in excessive friction, and the use of products that are aimed at 'moisturising without leaving a non-greasy feel' should be prevented. Most investigated dressings also demonstrate excellent performance.


Assuntos
Infecções por Coronavirus/complicações , Lubrificantes/uso terapêutico , Equipamento de Proteção Individual/efeitos adversos , Pneumonia Viral/complicações , Pele/lesões , Adulto , Betacoronavirus , Fenômenos Biomecânicos , Fricção , Humanos , Masculino , Corpo Clínico , Pandemias
4.
Clin Dermatol ; 38(4): 485-488, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32972607

RESUMO

Many factors affect the health and physiology of human skin, with some of them arising from outer space. This contribution explores four celestial influences on the skin: (1) the sun's ultraviolet light, which has both beneficial and deleterious dermatologic effects, (2) meteorite injuries, (3) possible lunar effects on the body's health, and (4) cosmic radiation as a risk factor for skin cancer and pregnancy-related complications. Some of these extraterrestrial influences on skin health have taken on added significance as human beings increasingly spend more time at higher altitudes in aircraft, spaceships, and space stations.


Assuntos
Radiação Cósmica/efeitos adversos , Neoplasias Cutâneas/etiologia , Pele/lesões , Pele/efeitos da radiação , Luz Solar/efeitos adversos , Raios Ultravioleta/efeitos adversos , Aeronaves , Altitude , Dermatite de Contato/etiologia , Feminino , Humanos , Masculino , Meteoroides , Lua , Gravidez , Complicações na Gravidez/etiologia
5.
Int J Nanomedicine ; 15: 5911-5926, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32848396

RESUMO

Purpose: Chronic refractory wounds are a multifactorial comorbidity of diabetes mellitus with the characteristic of impaired vascular networks. Currently, there is a lack of effective treatments for such wounds. Various types of mesenchymal stem cell-derived exosomes (MSC-exos) have been shown to exert multiple therapeutic effects on skin regeneration. We aimed to determine whether a constructed combination of human umbilical cord MSC (hUCMSC)-derived exosomes (hUCMSC-exos) and Pluronic F-127 (PF-127) hydrogel could improve wound healing. Materials and Methods: We topically applied human umbilical cord-derived MSC (hUCMSC)-derived exosomes (hUCMSC-exos) encapsulated in a thermosensitive PF-127 hydrogel to a full-thickness cutaneous wound in a streptozotocin-induced diabetic rat model. The material properties and wound healing ability of the hydrogel and cellular responses were analyzed. Results: Compared with hUCMSC-exos, PF-127-only or control treatment, the combination of PF-127 and hUCMSC-exos resulted in a significantly accelerated wound closure rate, increased expression of CD31 and Ki67, enhanced regeneration of granulation tissue and upregulated expression of vascular endothelial growth factor (VEGF) and factor transforming growth factor beta-1 (TGFß-1). Conclusion: The efficient delivery of hUCMSC-exos in PF-127 gel and improved exosome ability could promote diabetic wound healing. Thus, this biomaterial-based exosome therapy may represent a new therapeutic approach for cutaneous regeneration of chronic wounds.


Assuntos
Diabetes Mellitus Experimental/tratamento farmacológico , Exossomos/química , Hidrogéis/farmacologia , Células-Tronco Mesenquimais/citologia , Poloxâmero/química , Cicatrização/efeitos dos fármacos , Animais , Diabetes Mellitus Experimental/complicações , Pé Diabético/tratamento farmacológico , Pé Diabético/patologia , Células Endoteliais da Veia Umbilical Humana , Humanos , Hidrogéis/química , Masculino , Molécula-1 de Adesão Celular Endotelial a Plaquetas/metabolismo , Ratos Sprague-Dawley , Regeneração , Pele/efeitos dos fármacos , Pele/lesões , Fenômenos Fisiológicos da Pele , Estreptozocina , Cordão Umbilical/citologia , Fator A de Crescimento do Endotélio Vascular/genética , Cicatrização/fisiologia
6.
Hu Li Za Zhi ; 67(4): 81-88, 2020 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-32748382

RESUMO

BACKGROUND & PROBLEMS: Medical adhesives are typically used to fix wound dressings and catheters in place. Medical adhesive-related skin injuries (MARSI) are frequently caused by repetitive or improper usage of these products. The incidence rate in this unit is as high as 12.5%, which increases the difficulty and cost of care. After analysis of the situation, we identified the main causes of MARSI in our unit as: (1) Inadequate use of medical-adhesive products, (2) Lack of relevant education and training to prevent MARSI, and (3) lack of a standardized skin-damage-care procedure. PURPOSE: To decrease the incidence of MARSI in the pediatric intensive care unit. RESOLUTIONS: A training program was enacted to teach proper medical-adhesive application and removal techniques to caregivers. Consensus on care procedures was reached and care standards were modified. A mechanism for quality control was established. RESULTS: After implementing the program, the incidence of MARSI dropped from 12.5% to 5.18%, which achieved the target of this project. CONCLUSIONS: Other caregivers at our institution remain unaware of MARSI prevention techniques and protocols. We plan to continue cooperating with other staff members to prevent MARSI and to continue to reduce related skin injuries to as close to nil as possible.


Assuntos
Adesivos/efeitos adversos , Unidades de Terapia Intensiva Pediátrica , Recursos Humanos de Enfermagem no Hospital/educação , Higiene da Pele/enfermagem , Pele/lesões , Criança , Humanos , Incidência , Pesquisa em Avaliação de Enfermagem
7.
Nat Commun ; 11(1): 3823, 2020 07 30.
Artigo em Inglês | MEDLINE | ID: mdl-32732934

RESUMO

An accurate extraction of physiological and physical signals from human skin is crucial for health monitoring, disease prevention, and treatment. Recent advances in wearable bioelectronics directly embedded to the epidermal surface are a promising solution for future epidermal sensing. However, the existing wearable bioelectronics are susceptible to motion artifacts as they lack proper adhesion and conformal interfacing with the skin during motion. Here, we present ultra-conformal, customizable, and deformable drawn-on-skin electronics, which is robust to motion due to strong adhesion and ultra-conformality of the electronic inks drawn directly on skin. Electronic inks, including conductors, semiconductors, and dielectrics, are drawn on-demand in a freeform manner to develop devices, such as transistors, strain sensors, temperature sensors, heaters, skin hydration sensors, and electrophysiological sensors. Electrophysiological signal monitoring during motion shows drawn-on-skin electronics' immunity to motion artifacts. Additionally, electrical stimulation based on drawn-on-skin electronics demonstrates accelerated healing of skin wounds.


Assuntos
Monitorização Fisiológica/instrumentação , Sistemas Automatizados de Assistência Junto ao Leito , Pele/fisiopatologia , Dispositivos Eletrônicos Vestíveis , Artefatos , Estimulação Elétrica , Epiderme/fisiologia , Humanos , Movimento (Física) , Semicondutores , Auxiliares Sensoriais , Pele/lesões , Cicatrização
8.
Plast Reconstr Surg ; 146(3): 331e-338e, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32842115

RESUMO

BACKGROUND: Each year, millions of individuals develop scars secondary to surgery, trauma, and/or burns. Scar-specific patient-reported outcome measures to evaluate outcomes are needed. To address the gap in available measures, the SCAR-Q was developed following international guidelines for patient-reported outcome measure development. This study field tested the SCAR-Q and examined its psychometric properties. METHODS: Patients aged 8 years and older with a surgical, traumatic, and/or burn scar anywhere on their face or body were recruited between March of 2017 and April of 2018 at seven hospitals in four countries. Participants answered demographic and scar questions, the Fitzpatrick Skin Typing Questionnaire, the Patient and Observer Scar Assessment Scale (POSAS), and the SCAR-Q. Rasch measurement theory was used for the psychometric analysis. Cronbach's alpha, test-retest reliability, and concurrent validity were also examined. RESULTS: Consent was obtained from 773 patients, and 731 completed the study. Participants were aged 8 to 88 years, and 354 had surgical, 184 had burn, and 199 had traumatic scars. Analysis led to refinement of the SCAR-Q Appearance, Symptoms, and Psychosocial Impact scales. Reliability was high, with person separation index values of 0.91, 0.81, and 0.79; Cronbach alpha values of 0.96, 0.91, and 0.95; and intraclass correlation coefficient values of 0.92, 0.94, and 0.88, respectively. As predicted, correlations between POSAS scores and the Appearance and Symptom scales were higher than those between POSAS and Psychosocial Impact scale scores. CONCLUSIONS: With increasing scar revisions, a scar-specific patient-reported outcome measure is needed to measure outcomes that matter to patients from their perspective. The SCAR-Q represents a rigorously developed, internationally applicable patient-reported outcome measure that can be used to evaluate scars in research, clinical care, and quality improvement initiatives.


Assuntos
Cicatriz , Medidas de Resultados Relatados pelo Paciente , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Queimaduras/complicações , Canadá , Criança , Chile , Cicatriz/diagnóstico , Cicatriz/etiologia , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Nova Zelândia , Complicações Pós-Operatórias/diagnóstico , Psicometria , Autorrelato , Pele/lesões , Estados Unidos , Adulto Jovem
9.
PLoS One ; 15(8): e0237705, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32833973

RESUMO

Polychlorinated biphenyls (PCBs) are environmental pollutants and endocrine disruptors, harmfully affecting reproductive, endocrine, neurological and immunological systems. This broad influence has implications for processes such as wound healing, which is modulated by the immunological response of the body. Conversely, while PCBs can be linked to diminished wound healing, outside of PCB pollution systems, exercise has been shown to accelerate wound healing. However, the potential for moderate intensity exercise to modulate or offset the harmful effects of a toxin like PCB are yet unknown. A key aim of the present study was to examine how PCB exposure at different doses (0, 100, 500, 1000 ppm i.p.) altered wound healing in exercised versus non-exercised subgroups of mice. We examined PCB effects on immune function in more depth by analyzing the concentrations of cytokines, interleukin-1ß (IL-1ß), tumor necrosis factor-α (TNF-α), Interleukin-6 (IL-6) and granulocyte macrophage colony stimulating factor (GM-CSF) in these wounds inflicted by punch biopsy. Mice were euthanized at Day 3 or Day 5 after PCB injection (n = 3-6) and skin excised from the wound area was homogenized and analyzed for cytokine content. Results revealed that wound healing was not signficantly impacted by either PCB exposure or exercise, but there were patterns of delays in healing that depended on PCB dose. Changes in cytokines were also observed and depended on PCB dose and exercise experience. For example, IL-1ß concentrations in Day 5 mice without PCB administration were 33% less in exercised mice than mice not exercised. However, IL-1ß concentrations in Day 3 mice administered 100 ppm were 130% greater in exercised mice than not exercisedmice. Changes in the other measured cytokines varied with mainly depressions at lesser PCB doses and elevations at higher doses. Exercise had diverse effects on cytokine levels, but increased cytokine levels in the two greater doses. Explanations for these diverse effects include the use of young animals with more rapid wound healing rates less affected by toxin exposure, as well as PCB-mediated compensatory effects at specific doses which could actually enhance immune function. Future work should examine these interactions in more detail across a developmental time span. Understanding how manipulating the effects of exposure to environemntal contaminants using behavioral modification could be very useful in certain high risk populations or exposed individuals.


Assuntos
Disruptores Endócrinos/toxicidade , Poluentes Ambientais/toxicidade , Condicionamento Físico Animal/fisiologia , Bifenilos Policlorados/toxicidade , Cicatrização/imunologia , Animais , Citocinas/imunologia , Citocinas/metabolismo , Modelos Animais de Doenças , Feminino , Humanos , Camundongos , Pele/imunologia , Pele/lesões , Pele/metabolismo , Cicatrização/efeitos dos fármacos
10.
Leg Med (Tokyo) ; 47: 101762, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-32721867

RESUMO

A woman was stabbed 10 times and killed. The suspect confessed that he had used a thick (0.7 cm), single-edged survival knife with a serrated spine. However, the bilateral ends of the stab wounds appeared sharp. To address this discrepancy, we used pig skin to examine whether the knife could have been used to make the thin stab wounds observed. The widths of the pig skin wounds were approximately half the width of the knife and the ends of some wounds appeared sharp, particularly when the knife was held at a right angle. It was concluded that the suspect could have killed the victim using the survival knife. Similar pig skin experiments could be useful for forensic pathologists to determine whether a weapon of interest might have been used to inflict certain injuries.


Assuntos
Autopsia , Patologia Legal/métodos , Armas , Ferimentos Penetrantes/patologia , Animais , Feminino , Humanos , Pele/lesões , Pele/patologia , Suínos
11.
Adv Exp Med Biol ; 1207: 655-657, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32671783

RESUMO

Trauma is common in modern society. Besides TBI and SCI, trauma can lead to severe cardiopulmonary injury and even to death. Fracture and skin injury are also very likely to occur in our daily life. Limited studies have reported the levels of autophagy after heart and trauma, fracture, and skin injury. In this chapter, we update the current state of knowledge and recent advances in the study of autophagy after trauma including heart and lung trauma, fracture, and skin injury which we try to clarify how autophagy levels are affected by injury or trauma and how their manipulation may represent potential novel protective targets for treatments.


Assuntos
Autofagia , Ferimentos e Lesões/patologia , Fraturas Ósseas , Humanos , Pele/lesões , Ferimentos e Lesões/terapia
12.
Hum Cell ; 33(4): 990-1005, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32617892

RESUMO

Orchestrated control of multiple overlapping and sequential processes is required for the maintenance of epidermal homeostasis and the response to and recovery from a variety of skin insults. Previous studies indicate that membrane-associated serine protease matriptase and prostasin play essential roles in epidermal development, differentiation, and barrier formation. The control of proteolysis is a highly regulated process, which depends not only on gene expression but also on zymogen activation and the balance between protease and protease inhibitor. Subcellular localization can affect the accessibility of protease inhibitors to proteases and, thus, also represents an integral component of the control of proteolysis. To understand how membrane-associated proteolysis is regulated in human skin, these key aspects of matriptase and prostasin were determined in normal and injured human skin by immunohistochemistry. This staining shows that matriptase is expressed predominantly in the zymogen form at the periphery of basal and spinous keratinocytes, and prostasin appears to be constitutively activated at high levels in polarized organelle-like structures of the granular keratinocytes in the adjacent quiescent skin. The membrane-associated proteolysis appears to be elevated via an increase in matriptase zymogen activation and prostasin protein expression in areas of skin recovering from epidermal insults. There was no noticeable change observed in other regulatory aspects, including the expression and tissue distribution of their cognate inhibitors HAI-1 and HAI-2. This study reveals that the membrane-associated proteolysis may be a critical epidermal mechanism involved in responding to, and recovering from, damage to human skin.


Assuntos
Regulação da Expressão Gênica no Desenvolvimento , Expressão Gênica , Serina Endopeptidases/genética , Serina Endopeptidases/metabolismo , Fenômenos Fisiológicos da Pele/genética , Pele/lesões , Cicatrização/genética , Cicatrização/fisiologia , Ferimentos e Lesões/genética , Ferimentos e Lesões/metabolismo , Células Cultivadas , Precursores Enzimáticos/genética , Precursores Enzimáticos/metabolismo , Humanos , Glicoproteínas de Membrana/genética , Glicoproteínas de Membrana/metabolismo , Proteínas Secretadas Inibidoras de Proteinases/genética , Proteínas Secretadas Inibidoras de Proteinases/metabolismo , Proteólise , Serina Endopeptidases/fisiologia , Pele/metabolismo
13.
Sud Med Ekspert ; 63(4): 9-11, 2020.
Artigo em Russo | MEDLINE | ID: mdl-32686383

RESUMO

The work purpose is to identify objective morphological traits of punctured and stab and slash wounds obtained as a result of using the ice cracking tools. An experimental injury to the skin was carried out, followed by the study and analysis of morphological signs of wounds. It was established that, depending on the design features of the ice-cracking tools and the conditions of injury, the injuries have a number of similar characteristics with wounds from the other puncturing and stab and slash articles, as well as they have certain morphological features.


Assuntos
Ferimentos Perfurantes , Patologia Legal , Humanos , Gelo , Pele/lesões , Armas
16.
Sud Med Ekspert ; 63(3): 16-18, 2020.
Artigo em Russo | MEDLINE | ID: mdl-32597605

RESUMO

The aim of study is to identify morfological signs of the skin damage, formed by electric discharge of different models of tasers, and therefore to determine construction features characterizing taser's models, as well as to detect the conditions of traumatization. As a result of experiment it was revealed that various morphological skin damages are caused by difference in the configuration of taser's terminal elements. It gives reason for an objective conclusion about stun gun's specific model.


Assuntos
Queimaduras por Corrente Elétrica , Traumatismos por Eletricidade , Lesões dos Tecidos Moles , Humanos , Pele/lesões , Armas
17.
Proc Natl Acad Sci U S A ; 117(25): 14365-14375, 2020 06 23.
Artigo em Inglês | MEDLINE | ID: mdl-32513690

RESUMO

Proper resolution of inflammation is vital for repair and restoration of homeostasis after tissue damage, and its dysregulation underlies various noncommunicable diseases, such as cardiovascular and metabolic diseases. Macrophages play diverse roles throughout initial inflammation, its resolution, and tissue repair. Differential metabolic reprogramming is reportedly required for induction and support of the various macrophage activation states. Here we show that a long noncoding RNA (lncRNA), lncFAO, contributes to inflammation resolution and tissue repair in mice by promoting fatty acid oxidation (FAO) in macrophages. lncFAO is induced late after lipopolysaccharide (LPS) stimulation of cultured macrophages and in Ly6Chi monocyte-derived macrophages in damaged tissue during the resolution and reparative phases. We found that lncFAO directly interacts with the HADHB subunit of mitochondrial trifunctional protein and activates FAO. lncFAO deletion impairs resolution of inflammation related to endotoxic shock and delays resolution of inflammation and tissue repair in a skin wound. These results demonstrate that by tuning mitochondrial metabolism, lncFAO acts as a node of immunometabolic control in macrophages during the resolution and repair phases of inflammation.


Assuntos
Ácidos Graxos/metabolismo , Inflamação/imunologia , Macrófagos/imunologia , Subunidade beta da Proteína Mitocondrial Trifuncional/genética , RNA Longo não Codificante/metabolismo , Animais , Modelos Animais de Doenças , Técnicas de Silenciamento de Genes , Humanos , Lipopolissacarídeos/imunologia , Ativação de Macrófagos/genética , Macrófagos/metabolismo , Masculino , Camundongos , Subunidade beta da Proteína Mitocondrial Trifuncional/metabolismo , Oxirredução , Cultura Primária de Células , RNA Longo não Codificante/genética , Pele/imunologia , Pele/lesões , Cicatrização/imunologia
18.
Proc Natl Acad Sci U S A ; 117(25): 14354-14364, 2020 06 23.
Artigo em Inglês | MEDLINE | ID: mdl-32513697

RESUMO

Ischemic injury initiates a sterile inflammatory response that ultimately participates in the repair and recovery of tissue perfusion. Macrophages are required for perfusion recovery during ischemia, in part because they produce growth factors that aid in vascular remodeling. The input signals governing this pro-revascularization phenotype remain of interest. Here we found that hindlimb ischemia increases levels of resolvin D1 (RvD1), an inflammation-resolving lipid mediator that targets macrophages via its receptor, ALX/FPR2. Exogenous RvD1 enhances perfusion recovery during ischemia, and mice deficient in Alx/Fpr2 have an endogenous defect in this process. Mechanistically, RNA sequencing revealed that RvD1 induces a transcriptional program in macrophages characteristic of a pro-revascularization phenotype. Vascularization of ischemic skeletal muscle, as well as cutaneous wounds, is impaired in mice with myeloid-specific deficiency of Alx/Fpr2, and this is associated with altered expression of pro-revascularization genes in skeletal muscle and macrophages isolated from skeletal muscle. Collectively, these results uncover a role of ALX/FPR2 in revascularization that may be amenable to therapeutic targeting in diseases associated with altered tissue perfusion and repair.


Assuntos
Ácidos Docosa-Hexaenoicos/metabolismo , Isquemia/imunologia , Neovascularização Fisiológica/imunologia , Receptores de Formil Peptídeo/metabolismo , Receptores de Lipoxinas/metabolismo , Cicatrização/imunologia , Animais , Células Cultivadas , Modelos Animais de Doenças , Feminino , Técnicas de Inativação de Genes , Humanos , Isquemia/patologia , Macrófagos/imunologia , Macrófagos/metabolismo , Masculino , Camundongos , Camundongos Knockout , Músculo Esquelético/irrigação sanguínea , Músculo Esquelético/imunologia , Músculo Esquelético/patologia , Cultura Primária de Células , RNA-Seq , Receptores de Formil Peptídeo/genética , Receptores de Lipoxinas/genética , Transdução de Sinais/imunologia , Pele/irrigação sanguínea , Pele/imunologia , Pele/lesões , Pele/patologia , Transcrição Genética/imunologia
19.
J Wound Care ; 29(5): 245-259, 2020 May 02.
Artigo em Inglês | MEDLINE | ID: covidwho-294439

RESUMO

The 2019 novel coronavirus disease (COVID-19) pandemic has brought the effects of device-related pressure ulcers (DRPU) into sharp focus. With the increased use of personal protective equipment (PPE), including face masks, continuous positive airway pressure (CAPP) masks and other devices, the incidence of DRPUs among health professionals and patients alike has risen starkly. As such, the Journal of Wound Care (JWC) consensus document, Device-related pressure ulcers: SECURE prevention, published in February 2020, is more relevant than ever. To help support patients and frontline health professionals, JWC is republishing the consensus in a digital format, along with a new introductory article outlining the DRPU risks posed by PPE and other medical devices used by patients and health professionals during the pandemic, and how the skin damage can be avoided. The aim is to provide frontline staff with a clear, simple strategy on how to prevent the risk of personal skin damage and/or DRPU during the pandemic, as well as point them in the direction of more indepth guidance on long-term strategies for prevention, for both themselves and patients.


Assuntos
Infecções por Coronavirus/prevenção & controle , Equipamentos e Provisões/efeitos adversos , Controle de Infecções/normas , Máscaras/efeitos adversos , Pandemias/prevenção & controle , Equipamento de Proteção Individual/efeitos adversos , Pneumonia Viral/prevenção & controle , Lesão por Pressão/prevenção & controle , Infecções por Coronavirus/etiologia , Infecções por Coronavirus/transmissão , Transmissão de Doença Infecciosa/prevenção & controle , Traumatismos Faciais/etiologia , Traumatismos Faciais/prevenção & controle , Humanos , Controle de Infecções/métodos , Pneumonia Viral/etiologia , Pneumonia Viral/transmissão , Lesão por Pressão/etiologia , Pele/lesões , Dermatopatias/etiologia , Dermatopatias/prevenção & controle
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