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1.
Eur J Clin Invest ; 50(3): e13200, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31953953

RESUMO

BACKGROUND: Atrial fibrillation (AF) is common amongst the elderly, but this group tends to be suboptimally treated. Limited data are available on the stroke prevention strategies in the elderly, especially in the Balkan region. AIM: We investigated the use of oral anticoagulant therapy (OAC) amongst elderly AF patients in clinical practice in the Balkan region. METHOD: A 12-week prospective snapshot survey (2014-2015) of consecutive non-valvular AF patients was conducted in Albania, Bosnia and Herzegovina, Bulgaria, Croatia, Montenegro, Romania and Serbia. Data were collected via an electronic case report form. RESULTS: Of 2671 patients, 418 (15.6%) were ≥80 years old. Overall, OAC was used in 1965 patients (73.6%). Compared with younger patients, the elderly (age ≥ 80) had a higher mean CHA2 DS2 -VASc score (3.22 ± 1.71 vs 4.89 ± 1.35, P < .001) and more often a HAS-BLED score of ≥3 (n = 198 [47.0%] vs n = 625 [27.3%], P < .001), but were less likely to receive OAC (n = 269 [64.4%] vs n = 1696 [75.3%], odds ratio [OR] 0.91; 95%CI 0.86-0.97, P = .003). There was no significant association between OAC use and mean CHA2 DS2 -VASc (OR 0.86; 95%CI 0.75-1.00, P = .053) or HAS-BLED score (OR 1.21; 95%CI 0.81-1.81, P = .349) in the elderly. CONCLUSION: In the BALKAN-AF Survey, elderly AF patients were less likely to receive the guideline-adherent treatment despite their less favourable risk profile. Since OAC nonuse among the elderly was not associated with increased HAS-BLED score, factors other than patients' risk profile could influence the implementation of guideline-adherent treatment for thromboprophylaxis in the elderly AF patients.


Assuntos
Acidente Vascular Cerebral/prevenção & controle , Idoso , Idoso de 80 Anos ou mais , Fibrilação Atrial , Península Balcânica/epidemiologia , Comorbidade , Feminino , Humanos , Masculino , Fatores de Risco , Acidente Vascular Cerebral/epidemiologia
2.
Environ Sci Technol ; 54(3): 1554-1561, 2020 02 04.
Artigo em Inglês | MEDLINE | ID: mdl-31884786

RESUMO

Aristolochic acids (AAs) have been known as potent nephrotoxins since the use of AA-containing herbal medicines was linked with a series of sporadic renal fibrotic nephropathy cases, and yet an estimated 100 million people worldwide are still at risk today because of continued use of similar medicines. However, a similar nephropathic condition is endemic in the rural Balkan regions (e.g., Serbian farming villages) and AAs were again found to be the causative agents. In the case of this Balkan endemic nephropathy, AAs were found to have originated from a widespread local weed Aristolochia clematitis L. In this study, we tested the hypothesis that AAs released from decomposition of A. clematitis were also being leached into groundwater, thus polluting the drinking water of local residents. We initiated the study by developing a dispersive solid-phase extraction-based sample preparation method for water samples suspected of AA contamination. The validated method was then coupled with a liquid chromatography-tandem mass spectrometric method to measure AAs in groundwater samples collected from Serbia. Our study revealed for the first time that groundwater in Serbia is extensively contaminated with AA-I, at ng/L levels. Results also showed that AAs are long-lived water contaminants, with no observable concentration changes over a 2-month period of sample storage.


Assuntos
Ácidos Aristolóquicos , Nefropatia dos Bálcãs , Água Subterrânea , Península Balcânica , Humanos , Sérvia
3.
Zootaxa ; 4563(2): zootaxa.4563.2.9, 2019 Feb 28.
Artigo em Inglês | MEDLINE | ID: mdl-31716547

RESUMO

The Chironomidae of Albania have so far received limited attention and only 39 species have been recorded prior to the present study. Here we bring the results of random and non-intensive samplings of chironomid pupal exuviae and adults, at five localities in 2012, that provided 55 species and 5 additional taxa, with 51 being new for the Albanian fauna, out of which 7 were new for the Balkan Peninsula. In addition to that, we present a preliminary checklist of Chironomidae based on the data from Fauna Europaea complemented by the results of the recent investigation. The catalogued fauna now contains 85 species in 44 genera and 6 sub-families.


Assuntos
Chironomidae , Albânia , Animais , Península Balcânica , Pupa
4.
Zootaxa ; 4658(3): zootaxa.4658.3.7, 2019 Aug 23.
Artigo em Inglês | MEDLINE | ID: mdl-31716735

RESUMO

Geophilus serbicus sp. nov., a new epigeic centipede species, is described and illustrated based on specimens collected from the Stara Planina Mountains (the Balkan Mountain Range), Eastern Serbia, Balkan Peninsula. Considerations on the taxonomic relationships with some similar Geophilus species are briefly presented, and the distribution of the new species is mapped.


Assuntos
Artrópodes , Animais , Península Balcânica , Sérvia
5.
Zootaxa ; 4612(2): zootaxa.4612.2.3, 2019 May 29.
Artigo em Inglês | MEDLINE | ID: mdl-31717065

RESUMO

Limnephilus minos Malicky 1970 is a micro-endemic caddisfly restricted to the Greek island of Crete. Mesophylax impunctatus aduncus (Navás 1923) is known from Turkey and the southern Balkan peninsula; Greek records range from islands close to the mainland and Skiros to the northern mainland, and Attica. This paper describes the previously unknown larvae of both taxa. Information on the morphology of the 5th larval instar of each taxon is given, and the most important diagnostic characters are illustrated. A discriminatory matrix for the Greek limnephilid larvae with multifilament gills is also provided. In the context of existing identification keys, the larva of L. minos belongs to the group of Limnephilini larvae where face setae are lacking on the mid- and/or hind femora; the species keys together with L. auricula Curtis 1834 and can be separated from the latter species by setae present between the primary setae on the distal section of mid- and hind trochanters. In contrast, face setae are present on the mid- and/or hind femora in M. impunctatus aduncus. Its larva can be easily identified by the fact that 3 or more ventral-edge setae are present on the midfemur, by setae present on both sides of the anal slit, and by its grazer-type mandible lacking terminal teeth.


Assuntos
Brânquias , Insetos , Animais , Península Balcânica , Grécia , Ilhas , Larva , Turquia
6.
Zootaxa ; 4638(1): zootaxa.4638.1.5, 2019 Jul 15.
Artigo em Inglês | MEDLINE | ID: mdl-31712486

RESUMO

Comparative investigation of morphology and calling signals of Selenocephalus obsoletus (Germar, 1817) from different localities in Western Europe, Bulgaria, Ukraine, and Russia showed that this species includes two subspecies. S. obsoletus obsoletus occurs in the Mediterranean, S. obsoletus rossicus Zachvatkin, 1945, stat. n. is distributed from the steppes of Eastern Europe up to Bulgaria; the boundary between two subspecies in the Balkans coincides with the boundary of the Mediterranean Region. Lectotypes of Selenocephalus rossicus Zachvatkin, 1945 and Selenocephalus rossicus tesquicola Zachvatkin, 1945 are designated; the synonymy S. obsoletus rossicus = S. rossicus tesquicola syn. n. is established.


Assuntos
Hemípteros , Animais , Península Balcânica , Bulgária , Europa Oriental , Federação Russa , Ucrânia
7.
Zootaxa ; 4688(3): zootaxa.4688.3.8, 2019 Oct 23.
Artigo em Inglês | MEDLINE | ID: mdl-31719442

RESUMO

Titanoeca deltshevi sp. n. is described and illustrated from Bulgaria. It appears closely related to T. praefica (Simon, 1870), T. spominima (Taczanowski, 1866) and partially (males only) to T. flavicoma L. Koch, 1872. A faunistic synopsis of the genus Titanoeca Thorell, 1870 in Bulgaria is also presented that is based on new field data and a review of the published literature. Titanoeca flavicoma is newly recorded for Bulgaria and T. turkmenia Wunderlich, 1995 is new for Bulgaria and Albania. Titanoeca incerta (Nosek, 1905) is removed from the Bulgarian, and therefore from the European spider checklists. The possible division of the European members of Titanoeca into three groups based on differences in copulatory and somatic traits is discussed.


Assuntos
Aranhas , Albânia , Distribuição Animal , Animais , Península Balcânica , Bulgária , Masculino
8.
Environ Int ; 133(Pt A): 105158, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31622907

RESUMO

The SHERPA tool was used to assess the major pollution sources and the geographical areas impacting on the PM2.5 of the main cities in the Danube and Western Balkans regions. The activity sectors influencing most the PM2.5 levels in the study area are energy production (22%), agriculture (19%), residential combustion (16%) and road transport (7%). The energy production in inefficient coal-fuelled power plants was identified as one of main source of PM2.5 in the Western Balkans. As for the geographical origin of PM2.5, the transboundary pollution is confirmed as the main origin of PM2.5 (44%) in the investigated cities, while the city own emissions and the national sources outside the concerned city impact on average 22% and 15%, respectively. An association was observed between the long-range transport and the impact of agriculture and energy production, while both local urban emissions and long-range transport were associated with the residential sector. A special attention is given in this study to biomass, a renewable source, which use is often promoted in the frame of climate and energy policies. Nevertheless, the combustion of biomass in inefficient small appliances has considerable particulate matter emissions and therefore this type of practice impacts negatively on air quality. Considering that biomass is traditionally used in South-East Europe as fuel for residential heating, the interpretation of the model results was supported with the estimation of biomass burning contributions to PM2.5 obtained with receptor models and data on biomass fuel consumption from the literature. The analysis of the contributions from biomass burning derived from receptor models suggests that biomass burning is the dominant source within the residential heating sector in the studied area and that the emissions from this source are likely underestimated. This study concludes that more effort is needed to improve the estimations of biomass burning emissions and that policies to improve air quality in the cities should involve a geographic context wider than the city level.


Assuntos
Poluentes Atmosféricos/análise , Monitoramento Ambiental , Material Particulado/análise , Poluição do Ar/análise , Península Balcânica , Biomassa , Cidades , Carvão Mineral/análise , Monitoramento Ambiental/métodos , Europa (Continente) , Centrais Elétricas
9.
Environ Pollut ; 254(Pt A): 112948, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31377333

RESUMO

Large-scale synoptic conditions are able to transport considerable amounts of airborne particles over entire continents by creating substantial air mass movement. This phenomenon is observed in Europe in relation to highly allergenic ragweed (Ambrosia L.) pollen grains that are transported from populations in Central Europe (mainly the Pannonian Plain and Balkans) to the North. The path taken by atmospheric ragweed pollen often passes through the highly industrialised mining region of Silesia in Southern Poland, considered to be one of the most polluted areas in the EU. It is hypothesized that chemical air pollutants released over Silesia could become mixed with biological material and be transported to less polluted regions further North. We analysed levels of air pollution during episodes of long-distance transport (LDT) of ragweed pollen to Poland. Results show that, concomitantly with pollen, the concentration of air pollutants with potential health-risk, i.e. SO2, and PM10, have also significantly increased (by 104% and 37%, respectively) in the receptor area (Western Poland). Chemical transport modelling (EMEP) and air mass back-trajectory analysis (HYSPLIT) showed that potential sources of PM10 include Silesia, as well as mineral dust from the Ukrainian steppe and the Sahara Desert. In addition, atmospheric concentrations of other allergenic biological particles, i.e. Alternaria Nees ex Fr. spores, also increased markedly (by 115%) during LDT episodes. We suggest that the LDT episodes of ragweed pollen over Europe are not a "one-component" phenomenon, but are often related to elevated levels of chemical air pollutants and other biotic and abiotic components (fungal spores and desert dust).


Assuntos
Poluentes Atmosféricos/análise , Antígenos de Plantas/análise , Monitoramento Ambiental , Extratos Vegetais/análise , Esporos Fúngicos , Movimentos do Ar , Alérgenos/análise , Ambrosia , Península Balcânica , Poeira/análise , Monitoramento Ambiental/métodos , Minerais/análise , Polônia , Pólen/química
10.
Naturwissenschaften ; 106(7-8): 37, 2019 Jun 17.
Artigo em Inglês | MEDLINE | ID: mdl-31209578

RESUMO

Millipedes use an array of chemical compounds to defend themselves from predator attack. These chemical substances can have additional roles, i.e. defence against various pathogens. We evaluated the efficacy of the defensive secretion of Apfelbeckia insculpta (L. Koch, 1867) against bacteria, yeasts, and filamentous fungi. The tested secretion consisted of two compounds, p-cresol and phenol, and showed antibacterial, antibiofilm, and antifungal potential against all selected microorganisms. The most sensitive bacterium in our study was Pseudomonas aeruginosa, while the tested defensive secretion manifested the lowest activity against Escherichia coli. The defensive secretion of A. insculpta also showed an ability, albeit mild, to suppress biofilm formation by P. aeruginosa. Among the tested yeasts, Candida albicans and C. krusei were the most susceptible and most resistant species, respectively. Finally, the concentration of extracts obtained from the tested defensive secretion needed to achieve an antifungal effect was lowest in the case of Cladosporium cladosporioides. Fusarium verticillioides and Penicillium rubens were the micromycetes most resistant to the tested secretion. Our results indicate that antibacterial activity of the defensive secretion of A. insculpta is similar to or slightly weaker than that of streptomycin, while comparison with antimycotics showed that the tested millipede secretion has stronger activity than fluconazole, but weaker activity than nystatin and ketoconazole. The present study corroborates previous findings indicating that the defensive secretions of millipedes can have different roles apart from antipredator protection and are effective against pathogenic microorganisms.


Assuntos
Anti-Infecciosos/química , Anti-Infecciosos/farmacologia , Artrópodes/química , Bactérias/efeitos dos fármacos , Fungos/efeitos dos fármacos , Fenóis/química , Animais , Anti-Infecciosos/isolamento & purificação , Península Balcânica , Testes de Sensibilidade Microbiana
11.
Nurs Educ Perspect ; 40(6): E28-E30, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31169780

RESUMO

This article describes the process of competence-based curriculum development in nursing education at Western Balkan (WB) universities. Nursing education in the WB has been noncompliant with the standard educational approaches of the European Union's directive on regulated professions. The overall aim of the TEMPUS project "Competency-Based Curriculum Reform in Nursing and Caring in Western Balkan Universities" was to bring curricular reform for bachelor's nursing education in the WB region in line with competence-based education and professional standards to demonstrate compliance with all member countries of the European Union.


Assuntos
Educação Baseada em Competências/organização & administração , Currículo , Bacharelado em Enfermagem/organização & administração , Península Balcânica , Humanos
12.
Mol Phylogenet Evol ; 138: 193-204, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31129348

RESUMO

The evolutionary history of taxa with limited overseas dispersal abilities is considered to be majorly influenced by vicariant events constituting them as model organisms for the interpretation of evolutionary processes. An excellent candidate are the wall lizards of the genus Podarcis exhibiting an impressive level of genetic and morphological diversification and harboring several cases of recently discovered cryptic diversity. In this study, we investigated the effect of palaeogeographic events on the wall lizards' biodiversity patterns in the Aegean (Greece) as well as the evolutionary processes that acted both in space and time. To accomplish that we studied a group of three endemic Podarcis species (i.e., P. cretensis, P. levendis, and P. peloponnesiacus) both at the intra and interspecific levels employing mitochondrial and nuclear DNA sequence data as well as microsatellites. Furthermore, presence information coupled with bioclimatic data (i.e., species distribution modeling, and niche similarity analyses) shed light on the necessary ecological factors for the species' occurrence. These approaches revealed yet another case of cryptic diversity for this group of lizards, with the existence of two slightly overlapping lineages within P. peloponnesiacus and highly structured populations within P. cretensis. Species diversification occurred during the Pliocene with P. peloponnesiacus divergence into the two lineages dating back to 1.86 Mya. Furthermore, temperature and precipitation related environmental parameters were the most important ones regarding the current distribution of the studied species. Based on the results, we propose a more detailed phylogeographic scenario where both the paleogeography of the area and several environmental parameters have shaped the genetic diversity and the current distribution pattern of this species group.


Assuntos
Lagartos/classificação , Filogenia , Filogeografia , Animais , Península Balcânica , Biodiversidade , DNA Mitocondrial/genética , Variação Genética , Genética Populacional , Grécia , Lagartos/genética , Repetições de Microssatélites/genética , Especificidade da Espécie , Fatores de Tempo
13.
Transbound Emerg Dis ; 66(5): 2045-2057, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31127984

RESUMO

Lumpy skin disease virus (LSDV) is an infectious disease of cattle transmitted by arthropod vectors which results in substantial economic losses due to impact on production efficiency and profitability, and represents an emerging threat to international trade of livestock products and live animals. Since 2015, the disease has spread into the Northern Hemisphere including Azerbaijan, Kazakhstan, the Russian Federation and the Balkans. The rapid expansion of LSDV in those regions represented the emergence of the virus in more temperate regions than those in which LSDV traditionally occurred. The goal of this study was to assess the risk for further LSDV spread through the (a) analysis of environmental factors conducive for LSDV, and (b) estimate of the underlying LSDV risk, using a combination of ecological niche modelling and fine spatiotemporally explicit Bayesian hierarchical model on LSDV outbreak occurrence data. We used ecological niche modelling to estimate the potential distribution of LSDV outbreaks for 2014-2016. That analysis resulted in a spatial representation of environmental limits where, if introduced, LSDV is expected to efficiently spread. The Bayesian space-time model incorporated both environmental factors and the changing spatiotemporal distribution of the disease to capture the dynamics of disease spread and predict areas in which there is an increased risk for LSDV occurrence. Variables related to the average temperature, precipitation, wind speed, as well as land cover and host densities were important drivers explaining the observed distribution of LSDV in both modelling approaches. Areas of elevated LSDV risks were identified mainly in Russia, Turkey, Serbia and Bulgaria. The results suggest that, if current ecological and epidemiological conditions persist, further spread of LSDV in Eurasia may be expected. The results presented here advance our understanding of the ecological requirements of LSDV in temperate regions and may help in the design and implementation of prevention and surveillance strategies in the region.


Assuntos
Surtos de Doenças/veterinária , Doença Nodular Cutânea/epidemiologia , Vírus da Doença Nodular Cutânea/isolamento & purificação , Animais , Península Balcânica , Teorema de Bayes , Bulgária , Bovinos , Comércio , Doenças Transmissíveis Emergentes/epidemiologia , Doenças Transmissíveis Emergentes/virologia , Internacionalidade , Cazaquistão , Federação Russa/epidemiologia , Turquia
14.
Int J Public Health ; 64(6): 873-885, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30830244

RESUMO

OBJECTIVES: Dietary surveys are essential for guiding national efforts to reduce the burden of non-communicable disease, but individual-level dietary data are lacking in many low- and middle-income countries. We aimed to estimate the prevalence of inadequate and excessive intakes of specific nutrients in Bosnia and Herzegovina. METHODS: A dietary survey among 853 adults using two 24-h recalls. RESULTS: The majority of men (73%) and women (66%) were overweight/obese, and > 50% of participants had elevated blood pressure. Low intakes of N-3 polyunsaturated fatty acids, specifically α-linolenic acid (men: 94.4 mg/day among, women: 96.6 mg/day) and DHA + EPA (men: 18.2 mg/day, women: 16.0 mg/day), low fiber intake (women: 21.5 g/day), and high sodium (men: 3244 mg/day, women: 2291 mg/) and saturated fatty acids intakes (men: 29.2 g/day) were reported. There was also a suggestion of low intakes of vitamins A, B6, C and D (in both sexes), and of riboflavin, folate, B12 and calcium (in women). CONCLUSIONS: Our findings provide initial evidence on the Bosnian population's dietary habits and identify aspects that need attention. As the survey evolves into a continuing surveillance system, it will allow evaluation of dietary changes over time.


Assuntos
Epidemias/estatística & dados numéricos , Comportamento Alimentar/psicologia , Doenças não Transmissíveis/epidemiologia , Inquéritos Nutricionais , Pobreza/psicologia , Pobreza/estatística & dados numéricos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Península Balcânica/epidemiologia , Bósnia e Herzegóvina/epidemiologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Adulto Jovem
15.
Bol. latinoam. Caribe plantas med. aromát ; 18(2): 197-203, mar. 2019. tab, mapas
Artigo em Inglês | LILACS | ID: biblio-1007815

RESUMO

The chemical composition of essential oil obtained from the aerial parts of the Balkan endemic species Thymus longedentatus was studied by GC-MS. Twenty eight compounds, consisting 98.2% of the total components were detected in amounts exceeding 0.1%. The oil was characterized by relatively high concencentration of oxygentated monoterpenes (78.7%), among which citral isomers neral (27.5%) and geranial (30.3%) were the principal ones. In addition, 1,8-cineole (7.8%), trans-ß-ocimene (7.5%), and ß-myrcene (3.7%) were detected in significant ammounts. Germacrene D (4.4%) was found to be the main sesquiterpene in the essential oil.


Se estudió mediante GC-MS la composición química del aceite esencial obtenido de las partes aéreas de Thymus longedentatus, especie endémica de los Balcanes. Se detectaron veintiocho compuestos, que representaban un 98,2% del total de compuestos y que se encontraban en cantidades superiores al 0,1%. El aceite se caracterizó por una concentración relativamente alta de monoterpenos oxigenados (78.7%), entre los cuales los isómeros de citral, neral (27.5%) y geranial (30.3%) eran los principales. Además, se detectó 1,8-cineol (7,8%), trans-ß-ocimeno (7,5%) y ß-mirceno (3,7%) en cantidades significativas. Se encontró que Germacreno D (4.4%) es el principal sesquiterpeno en el aceite esencial.


Assuntos
Plantas Medicinais/química , Óleos Voláteis/química , Thymus (Planta)/química , Terpenos/análise , Óleos Voláteis/isolamento & purificação , Península Balcânica , Cromatografia Gasosa-Espectrometria de Massas
16.
Zootaxa ; 4545(3): 339-374, 2019 Jan 17.
Artigo em Inglês | MEDLINE | ID: mdl-30790905

RESUMO

Novel Unio spp. populations from Slovenia, the Italian peninsula, Sardinia and Sicily were genetically analysed in order to define the distribution and diversity of the genus Unio in Italy and neighbouring areas. The presence of two primarily allopatric autochtonous species, Unio elongatulus Pfeiffer, and Unio mancus Lamarck, is confirmed for the Italian peninsula, Corsica, Sardinia, and Sicily.Autochthonous populations of Unio elongatulus are present in the peri-Adriatic drainages of the Italian and Balkan peninsulas, south as far as the Ofanto River (Apulia, Italy) and Lake Skadar (Albania), while its presence in the Tyrrhenian rivers of Tuscany is likely due to anthropogenic introduction events. Conversely, Unio mancus turtonii Payraudeau, an endangered peri-Tyrrhenian taxon, was found with autochthonous populations in the Apennine-Tyrrhenian drainages of peninsular Italy, eastern Mediterranean France, Corsica, Sardinia and Sicily, while the actual autochthony of the single population found in the Ionian basin of the Italian peninsula (Bradano River, Basilicata) deserves further investigation. The Italian population of U. mancus requienii Michaud, reported from Lake Montepulciano is to be considered allochthonous.The binomen U. elongatulus, although widely used in the recent scientific literature, was, to date, assigned to a doubtful species, because its type locality includes a large area inhabited by different Unio taxa, which are not clearly distinguishable by their shell alone; furthermore, no type material is present in historical collections. To retain the recently-used name, a new restricted type locality is established, where only U. elongatulus lives, and a neotype is designated. The validity of the subspecies of Unio mancus is also discussed and confirmed.Finally, hypotheses on the origin of Italian mussels, and considerations on their conservation status are discussed.


Assuntos
Bivalves , Unio , Albânia , Animais , Península Balcânica , França , Itália , Sicília , Eslovênia
17.
Zootaxa ; 4559(1): 90-110, 2019 Feb 18.
Artigo em Inglês | MEDLINE | ID: mdl-30791029

RESUMO

Seven new species of the cavernicolous and anophthalmous genus Thaumastocephalus Poggi, Nonveiller, Colla, Pavicevic T. Rada, 2001 are described: T. bilandzijae sp. n., T. kirini sp. n., T. marsici sp. n., T. rujnicensis sp. n., T. slavkoi sp. n. and T. troglavi sp. n. from Croatia and T. dahnae sp. n. from Bosnia and Herzegovina. Aedeagi of all species are illustrated. A key to all species is provided. The records of all specimens of the genus treated here are given, and their distributions are discussed and shown on maps. The distribution of all genera of cavernicolous Pselaphinae in the Dinarides is discussed.


Assuntos
Besouros , Distribuição Animal , Animais , Península Balcânica , Bósnia e Herzegóvina , Cavernas , Croácia
19.
Clin Microbiol Rev ; 32(2)2019 03 20.
Artigo em Inglês | MEDLINE | ID: mdl-30700432

RESUMO

New Delhi metallo-ß-lactamase (NDM) is a metallo-ß-lactamase able to hydrolyze almost all ß-lactams. Twenty-four NDM variants have been identified in >60 species of 11 bacterial families, and several variants have enhanced carbapenemase activity. Klebsiella pneumoniae and Escherichia coli are the predominant carriers of bla NDM, with certain sequence types (STs) (for K. pneumoniae, ST11, ST14, ST15, or ST147; for E. coli, ST167, ST410, or ST617) being the most prevalent. NDM-positive strains have been identified worldwide, with the highest prevalence in the Indian subcontinent, the Middle East, and the Balkans. Most bla NDM-carrying plasmids belong to limited replicon types (IncX3, IncFII, or IncC). Commonly used phenotypic tests cannot specifically identify NDM. Lateral flow immunoassays specifically detect NDM, and molecular approaches remain the reference methods for detecting bla NDM Polymyxins combined with other agents remain the mainstream options of antimicrobial treatment. Compounds able to inhibit NDM have been found, but none have been approved for clinical use. Outbreaks caused by NDM-positive strains have been reported worldwide, attributable to sources such as contaminated devices. Evidence-based guidelines on prevention and control of carbapenem-resistant Gram-negative bacteria are available, although none are specific for NDM-positive strains. NDM will remain a severe challenge in health care settings, and more studies on appropriate countermeasures are required.


Assuntos
Escherichia coli/enzimologia , Klebsiella pneumoniae/enzimologia , beta-Lactamases/genética , beta-Lactamases/metabolismo , Antibacterianos/farmacologia , Proteínas de Bactérias/genética , Proteínas de Bactérias/metabolismo , Península Balcânica , Escherichia coli/classificação , Escherichia coli/efeitos dos fármacos , Escherichia coli/genética , Medicina Baseada em Evidências , Variação Genética , Humanos , Índia , Klebsiella pneumoniae/classificação , Klebsiella pneumoniae/efeitos dos fármacos , Klebsiella pneumoniae/genética , Oriente Médio , Filogeografia , Inibidores de beta-Lactamases/farmacologia
20.
J Eur Acad Dermatol Venereol ; 33 Suppl 2: 13-27, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30811698

RESUMO

BACKGROUND: Although considered as a first-group carcinogen, indoor tanning is a common practice in Europe. Euromelanoma is a pan-European skin cancer prevention campaign. OBJECTIVES: To compare several European countries in terms of the prevalence and determinants of sunbed use. METHODS: Participants in the Euromelanoma campaigns filled in questionnaires containing demographics and risk factors, including type/duration of sunbed use. Multivariate analyses adjusted for age, gender, education, skin type and year of survey were employed to assess factors independently associated with sunbed use in each country. RESULTS: In total, 227 888 individuals (67.4% females, median age 44, 63.4% highly educated, 71.9% skin types III-VI) from 30 countries participated. Overall, the prevalence of sunbed ever use was 10.6% (≤19-year-olds: 5.9%; 20 to 35-year-olds: 17.0%; >35-year-olds: 8.3%). Females displayed a higher prevalence than males in all countries. Balkan countries displayed the highest female/male ratios (≥4). Sunbed use was significantly more prevalent among skin type III-VI (14/30 countries) and highly educated participants (11/30 countries). Significant correlations were found between sunbed use prevalence and countries' latitude (P < 0.001) and sunshine (P = 0.002); Italy and Spain represented exceptions towards excessive exposure. Very different prevalence rates were found for Spain (19.3%) and Portugal (2.0%). Scandinavian countries ranked highest in sunbed use among ≤19-year-olds, Baltic countries among 20 to 35-year-olds. CONCLUSIONS: Sunbed use prevalence was higher in northern, sun-deprived countries, with the exception of Italy and Spain. The main determinants of sunbed use were age (young adults) and gender (females), whereas education and skin type had a less relevant effect. Geographic particularities were found in four regions: Iberian (prevalence ten times higher in Spain than Portugal), Balkan (prevalence disproportionately higher among women), Baltic (highest prevalence among young adults) and Scandinavian (highest prevalence among adolescents). These data have public health relevance for future interventions aimed at reducing sunbed use in Europe.


Assuntos
Melanoma/prevenção & controle , Neoplasias Cutâneas/prevenção & controle , Banho de Sol/estatística & dados numéricos , Adolescente , Adulto , Fatores Etários , Península Balcânica , Escolaridade , Feminino , Humanos , Masculino , Região do Mediterrâneo , Pessoa de Meia-Idade , Fatores de Risco , Países Escandinavos e Nórdicos , Fatores Sexuais , Pigmentação da Pele , Inquéritos e Questionários , Adulto Jovem
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