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1.
Artigo em Inglês | MEDLINE | ID: mdl-35524698

RESUMO

OBJECTIVES: To evaluate whether social isolation and loneliness mediates the relationship between hearing loss and depression symptoms in older adults in China. METHODS: A cross-sectional analysis was conducted of 3769 participants (aged≥60 years) in Shandong province of China. Hearing loss was assessed using Pure-Tone Audiometry test, depression symptoms using 15-item Geriatric Depression Scale, loneliness through UCLA Loneliness Scale and social isolation using Lubben Social Network Scale. Regression and bootstrap analyses were performed to test both direct associations of hearing loss and depression symptoms, and whether the mediating role of social isolation and loneliness. RESULTS: Overall, 44% of older adults had hearing loss, which was generally mild (30%) rather than moderate (10%), severe (3%) or profound (0.6%). Increasing levels of hearing loss was associated with increasing levels of social isolation and depressions. Hearing loss was also associated with loneliness, but here a threshold effect was apparent and no trend for increasing loneliness with increasing hearing loss. Models that included social isolation and loneliness showed an amelioration in the association of hearing loss and depression, although it remained significant at all levels of hearing loss. Overall, 8% of the total effect of hearing loss on depression symptoms was explained by the mediated effect through social isolation and 42% by loneliness. CONCLUSIONS: Psychosocial factors such as social isolation and loneliness might explain the association between hearing loss and depression. Interventions that address older adults' social isolation and loneliness may ameliorate depression in older adults with hearing loss.


Assuntos
Perda Auditiva , Solidão , Idoso , China/epidemiologia , Estudos Transversais , Depressão/epidemiologia , Perda Auditiva/psicologia , Humanos , Solidão/psicologia , Isolamento Social/psicologia
2.
Clin Interv Aging ; 17: 675-683, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35528802

RESUMO

Objective: Hearing and vision loss have been independently associated with frailty in older adults, but the relationship between concurrent hearing and visual impairment (dual sensory impairment) and frailty is not well understood. Therefore, we aimed to examine whether dual sensory impairment is associated with frailty in older adults. Methods: This cross-sectional study was based on the data from the West China Health and Aging Trend (WCHAT) study of community-dwelling individuals aged 60 years and older. Frailty status was evaluated by the FRAIL scale and categorized as robust, prefrail and frail. Hearing and vision functions were based on self-report. We used multinomial regression models to explore the association between dual sensory impairment and frailty. Results: Of 3985 participants, 1655 (41.5%) were male and the median age was 66 years (interquartile range: 61-68). Overall, 7.6% of participants reported hearing impairment only, 32.7% reported vision impairment only, and 28.6% reported dual sensory impairment. The prevalence of prefrailty and frailty was 60.7% and 6.1%, respectively. After adjustment for confounding variables, results from the multinomial regression analysis showed that dual sensory impairment was significantly associated with greater odds of becoming frail (OR = 2.17, 95% CI = 1.40-3.38) compared with no impairment. When stratified by gender, dual sensory impairment was significantly associated with frailty in women (OR = 2.42, 95% CI = 1.40-4.20) but not in men (OR = 1.30, 95% CI = 0.58-2.91). Conclusion: Older adults with dual sensory impairment are more likely to be frail than those with no impairment, suggesting that interventions to improve sensory function may potentially help reduce the risk of frailty in older adults.


Assuntos
Fragilidade , Perda Auditiva , Idoso , Envelhecimento , China/epidemiologia , Estudos Transversais , Feminino , Idoso Fragilizado , Fragilidade/epidemiologia , Avaliação Geriátrica/métodos , Perda Auditiva/epidemiologia , Humanos , Masculino , Pessoa de Meia-Idade
3.
BMJ Case Rep ; 15(5)2022 May 03.
Artigo em Inglês | MEDLINE | ID: mdl-35504671

RESUMO

Neurobrucellosis is a zoonotic infection transmitted by infected animals or by contact with animal products and is an important health problem in resource-limited settings. In this case report, we present the case of a middle-aged man presenting with encephalomyelitis with hearing loss and diagnosed with neurobrucellosis based on imaging and serological tests. Because brucellosis infection is indolent, a high index of suspicion should be maintained in individuals presenting with fever, neurological signs and symptoms so that early management can prevent long-term neurological sequelae such as focal neurological deficits, hydrocephalus and psychiatric sequelae.


Assuntos
Brucelose , Surdez , Encefalomielite , Perda Auditiva , Hidrocefalia , Brucelose/complicações , Brucelose/diagnóstico , Brucelose/tratamento farmacológico , Surdez/complicações , Encefalomielite/complicações , Perda Auditiva/complicações , Humanos , Hidrocefalia/etiologia , Pessoa de Meia-Idade
4.
J Vis Exp ; (182)2022 Apr 21.
Artigo em Inglês | MEDLINE | ID: mdl-35532259

RESUMO

The loss of ribbon synapses connecting inner hair cells and afferent auditory nerve fibers is assumed to be one cause of age-related hearing loss. The most common method for detecting the loss of ribbon synapses is immunolabeling because it allows for quantitative sampling from several tonotopic locations in an individual cochlea. However, the structures of interest are buried deep inside the bony cochlea. Gerbils are used as an animal model for age-related hearing loss. Here, routine protocols for fixation, immunolabeling gerbil cochlear whole mounts, confocal imaging, and quantifying ribbon synapse numbers and volumes are described. Furthermore, the particular challenges associated with obtaining good material from valuable aging individuals are highlighted. Gerbils are euthanized and either perfused cardiovascularly, or their tympanic bullae are carefully dissected out of the skull. The cochleae are opened at the apex and base and directly transferred to the fixative. Irrespective of the initial method, the cochleae are postfixed and subsequently decalcified. The tissue is then labeled with primary antibodies against pre- and postsynaptic structures and hair cells. Next, the cochleae are incubated with secondary fluorescence-tagged antibodies that are specific against their respective primary ones. The cochleae of aged gerbils are then treated with an autofluorescence quencher to reduce the typically substantial background fluorescence of older animals' tissues. Finally, cochleae are dissected into 6-11 segments. The entire cochlear length is reconstructed such that specific cochlear locations can be reliably determined between individuals. Confocal image stacks, acquired sequentially, help visualize hair cells and synapses at the chosen locations. The confocal stacks are deconvolved, and the synapses are either counted manually using ImageJ, or more extensive quantification of synaptic structures is carried out with image analysis procedures custom-written in Matlab.


Assuntos
Cóclea , Perda Auditiva , Animais , Gerbillinae , Células Ciliadas Auditivas Internas , Sinapses
5.
Neurol India ; 70(2): 554-562, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35532619

RESUMO

Background: This study aimed to delineate the underlying pathophysiology of tinnitus between normal hearing and hearing loss subjects. Objective: The study aimed to characterize the neuropsychological aspects of two types of groups with tinnitus having variable hearing thresholds. Materials and Methods: The study sample comprises 75 subjects in a group with tinnitus and normal hearing, and 100 subjects in the tinnitus and hearing loss group. Subjects were matched to their respective controls for age, gender, and education levels. Subjects underwent verbal learning and memory tasks, visual learning, memory, listening attention, sustained visual attention, work memory, category control, phonemic mastery, response inhibition, and data processing velocity. Results and Conclusions: Subjects having hearing loss with bilateral tinnitus showed significantly reduced performance on total learning capacity (P = 0.02) and recognition (P = 0.05) (Rey's auditory verbal learning test), auditory attention tasks, digit forward span test (DFST) (P = 0.03), digit span test score (P = 0.01), and working memory (P = 0.02) (digit backward span test). For response inhibition tasks and Stroop interference (P = 0.03), subjects with normal hearing with bilateral tinnitus displayed lower performance. This study proves a relationship between poor working memory, auditory memory, total learning capacity, and recognition due to hearing impairment in bilateral Tinnitus subjects. The study has substantial implications for effective assessment and treatment recommendations in hearing loss with bilateral tinnitus subjects.


Assuntos
Surdez , Perda Auditiva , Zumbido , Cognição/fisiologia , Perda Auditiva/complicações , Humanos , Memória de Curto Prazo/fisiologia , Zumbido/complicações , Aprendizagem Verbal
6.
Adv Gerontol ; 35(1): 93-101, 2022.
Artigo em Russo | MEDLINE | ID: mdl-35522114

RESUMO

Cognitive function is a complex brain function that is important in the cognition of the reality and connecting with it. It has a complicated reflex basis, arises from external factors exposure, improves by growing up and learning till its maximum and declines in the elderly age. For several years it was believed that cognitive function drop is connected with ageing processes of the whole organism. However, the results of the latest studies show that it can be affected by many factors. Two of the most influencing factors are hearing and vestibular efficiency. Moreover, hearing and vestibular normalization can even improve the cognitive function. Unfortunately, studies, that describe the role of hearing and vestibular function in the cognitive sphere, are extremely rare. That is why further research is very important, especially in the rehabilitation tactics. For elderly patients with severe-to-profound hearing loss cochlear implantation is the optimal rehabilitation method. However, ear surgery can lead to such complication as vestibular dysfunction. That is why preoperative diagnostics and postoperative care are very important for preventing cognitive impairments.


Assuntos
Implante Coclear , Disfunção Cognitiva , Perda Auditiva , Idoso , Implante Coclear/efeitos adversos , Cognição , Disfunção Cognitiva/diagnóstico , Disfunção Cognitiva/etiologia , Audição , Perda Auditiva/diagnóstico , Perda Auditiva/etiologia , Humanos
8.
JAMA Netw Open ; 5(5): e2210734, 2022 May 02.
Artigo em Inglês | MEDLINE | ID: mdl-35511175

RESUMO

Importance: Hearing and vision problems are individually associated with increased dementia risk, but the impact of having concurrent hearing and vision deficits, ie, dual sensory impairment (DSI), on risk of dementia, including its major subtypes Alzheimer disease (AD) and vascular dementia (VaD), is not well known. Objective: To evaluate whether DSI is associated with incident dementia in older adults. Design, Setting, and Participants: This prospective cohort study from the Cardiovascular Health Study (CHS) was conducted between 1992 and 1999, with as many as 8 years of follow-up. The multicenter, population-based sample was recruited from Medicare eligibility files in 4 US communities with academic medical centers. Of 5888 participants aged 65 years and older in CHS, 3602 underwent cranial magnetic resonance imaging and completed the modified Mini-Mental State Examination in 1992 to 1994 as part of the CHS Cognition Study. A total of 227 participants were excluded due to prevalent dementia, leaving a total of 3375 participants without dementia at study baseline. The study hypothesis was that DSI would be associated with increased risk of dementia compared with no sensory impairment. The association between the duration of DSI with risk of dementia was also evaluated. Data analysis was conducted from November 2019 to February 2020. Exposures: Hearing and vision impairments were collected via self-report at baseline and as many as 5 follow-up visits. Main Outcomes and Measures: All-cause dementia, AD, and VaD, classified by a multidisciplinary committee using standardized criteria. Results: A total of 2927 participants with information on hearing and vision at all available study visits were included in the analysis (mean [SD] age, 74.6 [4.8] years; 1704 [58.2%] women; 455 [15.5%] African American or Black; 2472 [85.5%] White). Compared with no sensory impairment, DSI was associated with increased risk of all-cause dementia (hazard ratio [HR], 2.60; 95% CI, 1.66-2.06; P < .001), AD (HR, 3.67; 95% CI, 2.04-6.60; P < .001) but not VaD (HR, 2.03; 95% CI, 1.00-4.09; P = .05). Conclusions and Relevance: In this cohort study, DSI was associated with increased risk of dementia, particularly AD. Evaluation of hearing and vision in older adults may help to identify those at high risk of developing dementia.


Assuntos
Doença de Alzheimer , Perda Auditiva , Idoso , Doença de Alzheimer/complicações , Estudos de Coortes , Feminino , Audição , Perda Auditiva/complicações , Humanos , Masculino , Medicare , Estudos Prospectivos , Estados Unidos/epidemiologia , Transtornos da Visão/diagnóstico
12.
Washington, D.C.; Organisation panaméricaine de la Santé; 2022-05-05.
Não convencional em Francês | PAHO-IRIS | ID: phr-55961

RESUMO

Le présent manuel est l’aboutissement d’un processus de consultation mené par l’Organisation mondiale de la Santé. Il s’adresse à toutes les personnes qui prévoient d’instaurer un programme de dépistage auditif à l’échelon national ou infranational : coordinateurs de soins de l’oreille et de l’audition ou points focaux au sein des ministères de la Santé, planificateurs en santé publique, organisations non gouvernementales ou entités de la société civile qui prodiguent des soins de l’oreille et de l’audition. Cet ouvrage contient des informations pratiques visant à faciliter le dépistage des pertes auditives et des maladies connexes de l’oreille ainsi que l’intervention précoce chez les nouveau-nés et les nourrissons, les enfants d’âge préscolaire et scolaire ainsi que les personnes âgées. Ce manuel contient aussi des conseils sur des facteurs importants à prendre en compte lors de l’élaboration d’un programme de dépistage auditif : sujets devant faire l’objet du dépistage, objectif du programme, fréquence du dépistage, outils à employer, etc.


Assuntos
Audição , Perda Auditiva , Otopatias , Serviços de Reabilitação , Monitoramento do Ruído , Acesso a Medicamentos Essenciais e Tecnologias em Saúde
13.
Transpl Int ; 35: 10198, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35497888

RESUMO

It is not known whether hearing disorders improves with kidney transplantation. One of the neurotoxic effects of immunosuppressive drugs may be unrecognized hearing loss. In this study, our aim was to evaluate the hearing disorders in kidney transplant patients. Hearing problems in 46 kidney transplant patients [eGFR ≥ 60 ml/min/1.73 m2 (30 Tacrolimus, 16 mTOR inhibitor users)], 23 hemodialysis patients, and 20 healthy controls were evaluated with a questionnaire and high-frequency audiometry. More than half (58.7%) of the transplant patients had at least one hearing problem. Hearing loss was observed in 50%, 60.9% and 76.1% of the transplant patients at 8,000, 16,000 and 20,000 Hz. Hearing thresholds of transplant and hemodialysis patients increased from 4,000 to 20,000 Hz and was higher than that of controls. Hearing thresholds were higher at 1,000-2,000 Hz in patients using tacrolimus and at 16,000-20,000 Hz in patients using mTOR inhibitor. No correlation was found between hearing threshold and blood tacrolimus or mTOR inhibitor levels. Most kidney transplant and hemodialysis patients have hearing loss at higher frequencies than medium frequencies. Hearing loss in chronic kidney patients is likely to be permanent and kidney transplantation may not improve hearing problems. Hearing problems may be more pronounced at medium frequencies in patients receiving tacrolimus but at higher frequencies in patients receiving mTOR inhibitors.


Assuntos
Perda Auditiva , Transplante de Rim , Perda Auditiva/etiologia , Humanos , Transplante de Rim/efeitos adversos , Tacrolimo/efeitos adversos , Transplantados
14.
J Int Adv Otol ; 18(2): 106-111, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-35418357

RESUMO

OBJECTIVE: There is a need for regular surveillance of the hearing of children, no matter what their age. Screening of the hearing of school children can be done quickly and cheaply using teleaudiology. The primary aim of this study was to identify children who showed a suspected hearing impairment from rural areas of the Kujawsko-Pomorskie region and refer them for further audiological testing. A secondary aim was to estimate the prevalence of hearing loss in those children. METHODS: There were 4754 children, made up of 1840 children aged 6-7 years old and 2914 children aged 12-13 years old. Pure-tone air conduction thresholds were obtained at 0.5-8 kHz. Audiometric test was supplemented by results of a brief questionnaire filled in by parents. RESULTS: Of the 4754 children, 618 (13%) failed screening and were referred for detailed audiological diagnostics. The prevalence of hearing loss was estimated to be 7% and was significantly higher (OR = 2.12) in the group aged 6-7 y/o (10.1%) than in the group aged 12-13 y/o (5.0%). In our study the estimated prevalence of HL was twice as high in children aged 6-7 y/o (10.1%) than in children 12-13 y/o (5.0%). This difference was also evident in another study of Polish children from rural areas, where the prevalence of HL was 11.4% in younger children (6-9 y/o) and 5.5% in older children (12-13 y/o). CONCLUSION: Large numbers of school-age children in rural areas have hearing problems. It is recommended that a hearing screening program in primary schools based on e-health solutions should be adopted.


Assuntos
Surdez , Perda Auditiva , Adolescente , Audiometria de Tons Puros/métodos , Criança , Audição , Perda Auditiva/diagnóstico , Perda Auditiva/epidemiologia , Humanos , Polônia/epidemiologia
15.
J Int Adv Otol ; 18(2): 167-176, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-35418366

RESUMO

BACKGROUND: Nowadays, immunosuppressant drugs are widely used to prevent rejection in organ transplantation and to treat autoimmune diseases. Ototoxicity related to immunosuppressant drugs has been anecdotally reported but scarcely investigated. The aim of this investigation was to systematically review the available data on ototoxicity due to immunosuppressant therapy for transplantation or autoimmune disease. METHODS: A search of electronic databases (PubMed, Web of Science, and Scopus) was performed in order to identify studies concerning otovestibular toxicity due to immunosuppressant therapy for transplantation or autoimmune disease between January 1980 and November 2020. RESULTS: Eighteen articles were considered eligible for the review. Totally 131 patients experienced ototoxicity related to immunosuppressive treatment. Hearing loss was the most common clinical manifestation (128 cases) and was mainly bilateral. Tinnitus was reported in 52 cases and vertigo in 2. The immunosuppressant drugs most frequently involved in ototoxic manifestations were calcineurin inhibitors (cyclosporine and tacrolimus), often related to their high serum levels. CONCLUSION: Immunosuppressant-related ototoxicity is clinically relevant in uncommon but definitely challenging situations. Clinicians should be aware of this and inquire about hearing impairment symptoms during therapy and refer symptomatic patients to an otolaryngologist/audiologist. Further large-scale, prospective investigations are necessary to better characterize the ototoxicity of each class of immunosuppressants.


Assuntos
Doenças Autoimunes , Perda Auditiva , Ototoxicidade , Doenças Autoimunes/tratamento farmacológico , Perda Auditiva/induzido quimicamente , Humanos , Imunossupressores/efeitos adversos , Ototoxicidade/etiologia , Estudos Prospectivos
16.
S Afr J Commun Disord ; 69(1): e1-e13, 2022 Mar 31.
Artigo em Inglês | MEDLINE | ID: mdl-35384675

RESUMO

BACKGROUND:  South Africa has a high burden of drug-resistant tuberculosis (DRTB) and until recently, ototoxic aminoglycosides were predominant in treatment regimens. Community-based ototoxicity monitoring programmes (OMPs) have been implemented for early detection of hearing loss and increased patient access. OBJECTIVES:  A longitudinal study was conducted to describe the service delivery characteristics of a community-based OMP for DRTB patients facilitated by CHWs as well as observed ototoxic hearing loss in this population. METHOD:  A descriptive retrospective record review of longitudinal ototoxicity monitoring of 194 DRTB patients undergoing treatment at community-based clinics in the city of Cape Town between 2013 and 2017. RESULTS:  Follow-up rates between consecutive monitoring assessments reached as high as 80.6% for patients assessed by CHWs. Few patients (14.2% - 32.6%) were assessed with the regularity (≥ 6 assessments) and frequency required for effective ototoxicity monitoring, with assessments conducted, on average, every 53.4-64.3 days. Following DRTB treatment, 51.5% of patients presented with a significant ototoxic shift meeting one or more of the American Speech-Language-Hearing Association (ASHA) criteria. Deterioration in hearing thresholds was bilateral and most pronounced at high frequencies (4 kHz - 8 kHz). The presence of pre-existing hearing loss, human immunodeficiency virus co-infection and a history of noise exposure were significant predictors of ototoxicity in patients. CONCLUSION:  DRTB treatment with kanamycin resulted in significant deterioration of hearing longitudinally, predominantly at high frequencies. With ongoing training and supportive supervision, CHWs can facilitate community-based ototoxicity monitoring of DRTB patients. Current protocols and guidelines may require reassessment for appropriate community-based ototoxicity monitoring.


Assuntos
Perda Auditiva , Ototoxicidade , Tuberculose Resistente a Múltiplos Medicamentos , Perda Auditiva/induzido quimicamente , Perda Auditiva/diagnóstico , Perda Auditiva/epidemiologia , Humanos , Estudos Longitudinais , Ototoxicidade/etiologia , Estudos Retrospectivos , África do Sul , Tuberculose Resistente a Múltiplos Medicamentos/tratamento farmacológico
17.
Medicine (Baltimore) ; 101(7): e28828, 2022 Feb 18.
Artigo em Inglês | MEDLINE | ID: mdl-35363175

RESUMO

RATIONALE: Collagen type XI alpha 2 chain is a component of type XI collagen and is expressed in various tissues including articular cartilage and tectorial membrane of the cochlea. Variants in the COL11A2 gene, which encodes collagen type XI alpha 2 chain, has been reported to cause hearing loss and has been associated with osteoarthritis and ossification of the posterior longitudinal ligament of the spine. Despite the importance of type XI collagen in the joints, association of rheumatoid arthritis (RA) with COL11A2 has not been reported. PATIENT CONCERNS: The patient is a 60-year-old female, born to Japanese parents of no known consanguinity. She had progressive hearing loss since childhood. Her father also had progressive hearing loss before middle age. She developed joint pain in the knees and the hips in her forties. When she was 56, she developed polyarthritis. Rheumatoid factor and anti-CCP antibodies were positive. DIAGNOSES: She was diagnosed with osteoarthritis and RA. Whole exome analysis detected 2 rare variants, c.4201C>T, p.(Arg1401Trp) and c4265C>T, p.(Pro1422Leu), in the COL11A2 gene (NM_080680.2). Whole genome analysis with a long insert size confirmed 2 variants that are in trans. INTERVENTIONS AND OUTCOMES: She received a cochlear implant, which improved her hearing. She was treated with methotrexate, golimumab, tocilizumab, and upadacitinib with partial responses for her RA. LESSONS: We herein report a patient with RA with compound heterozygous variants in the COL11A2 gene. Autoantibodies against type XI collagen are detected in the sera of patients with RA, suggesting the possibility that type XI collagen may be involved in the pathogenesis of RA as an autoantigen. The hearing loss and osteoarthritis in this patient may be due to the compound heterozygous variants in the COL11A2 gene, and the conformational changes induced by the variants may have changed the immunogenicity of type XI collagen, leading to the development of RA.


Assuntos
Artrite Reumatoide , Surdez , Perda Auditiva , Osteoartrite , Artrite Reumatoide/complicações , Artrite Reumatoide/genética , Colágeno Tipo XI/genética , Feminino , Perda Auditiva/genética , Humanos , Pessoa de Meia-Idade , Osteoartrite/genética
18.
J Acoust Soc Am ; 151(3): 2027, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-35364904

RESUMO

Central auditory nervous system dysfunction (CANSD) can manifest as hearing difficulty in the absence of audiometric abnormalities. Effects of noise or jet fuel exposure on the CANS are documented in animal models and humans. This study screened military personnel using the modified Amsterdam Inventory for Auditory Disability (mAIAD) to assess whether concurrent jet fuel and noise (JFN) exposures potentiate central auditory difficulties compared to noise only exposures. A total of 48 age- and sex-matched participants were recruited: 24 military bulk fuel specialists (JFN) and 24 military personnel without jet fuel exposure. All participants completed the mAIAD, the Noise Exposure Questionnaire, and basic audiological testing. Results revealed non-significant differences in pure-tone thresholds between groups, but the JFN group had higher noise exposures. Additionally, the JFN group revealed consistently lower mAIAD scores compared to the noise only group. Interestingly, a JFN stratified subgroup reporting more listening difficulty exhibited statistically significant lower mAIAD scores in the speech intelligibility in noise subdomain. These preliminary data suggest that jet fuel exposure may potentiate noise-induced CANSD, such as speech-in-noise difficulties. Such difficulties may be more prominent among specific military personnel with combined exposures. Hearing conservation programs could add CANSD screening by use of the mAIAD.


Assuntos
Perda Auditiva , Militares , Animais , Testes Auditivos , Humanos , Ruído/efeitos adversos
19.
J Acoust Soc Am ; 151(3): 1639, 2022 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-35364956

RESUMO

Auditory temporal processing declines with age, leading to potential deleterious effects on communication. In young normal-hearing listeners, perceptual rate discrimination is rate limited around 300 Hz. It is not known whether this rate limitation is similar in older listeners with hearing loss. The purpose of this study was to investigate age- and hearing-loss-related rate limitations on perceptual rate discrimination, and age- and hearing-loss-related effects on neural representation of these stimuli. Younger normal-hearing, older normal-hearing, and older hearing-impaired listeners performed a pulse-rate discrimination task at rates of 100, 200, 300, and 400 Hz. Neural phase locking was assessed using the auditory steady-state response. Finally, a battery of non-auditory cognitive tests was administered. Younger listeners had better rate discrimination, higher phase locking, and higher cognitive scores compared to both groups of older listeners. Aging, but not hearing loss, diminished neural-rate encoding and perceptual performance; however, there was no relationship between the perceptual and neural measures. Higher cognitive scores were correlated with improved perceptual performance, but not with neural phase locking. This study shows that aging, rather than hearing loss, may be a stronger contributor to poorer temporal processing, and cognitive factors such as processing speed and inhibitory control may be related to these declines.


Assuntos
Surdez , Perda Auditiva , Idoso , Percepção Auditiva , Perda Auditiva/diagnóstico , Testes Auditivos , Humanos
20.
BMJ Open ; 12(4): e058464, 2022 Apr 26.
Artigo em Inglês | MEDLINE | ID: mdl-35473730

RESUMO

OBJECTIVE: To assess the prevalence of vision impairment, hearing impairment and dual sensory impairment (DSI) as combination of vision and hearing impairment, in association with cognitive dysfunction in a population aged 85+ years. METHODS: The cross-sectional population-based Ural Very Old Study, conducted in rural and urban Bashkortostan, Russia, between 2017 and 2020, included a detailed ocular and systemic examination with assessment of moderate to severe vision impairment (MSVI)/blindness (best-corrected visual acuity <6/18), moderate to severe hearing loss (MSHL) and cognitive function. SETTING: A rural and urban area in Bashkortostan, Russia. PARTICIPANTS: Out of 1882 eligible individuals aged 85+ years, 1526 (81.1%) individuals participated. PRIMARY AND SECONDARY OUTCOME MEASURES: Prevalence of vision, hearing and DSI and cognitive dysfunction. RESULTS: The study included 731 (47.9%) individuals (mean age 88.1±2.7 years; median 87 years, range 85-98 years) with measurements of MSVI/blindness, MSHL and cognitive function. The prevalence of MSVI/blindness, MSHL, DSI and dementia were 51.8% (95% CI 48.2% to 55.5%), 33.1% (95% CI 29.7% to 36.5%), 20.5% (95% CI 17.8% to 23.5%) and 48.2% (95% CI 44.5% to 51.8%), respectively. Lower cognitive function score was associated with lower visual acuity (p<0.001) and higher hearing loss score (p=0.03), after adjusting for older age (p=0.001), rural region of habitation (p=0.003), lower educational level (p<0.001) and higher depression score (p<0.001). Higher dementia prevalence was associated with higher MSHL prevalence (OR 2.18 95% CI 1.59 to 2.98; p<0.001), higher MSVI/blindness prevalence (OR 2.09, 95% CI 1.55 to 2.81; p<0.001) and higher DSI prevalence (OR 2.80, 95% CI 1.92 to 4.07; p<0.001). CONCLUSIONS: In this very old, multiethnic population from Russia, DSI (prevalence 20.5%), as compared with hearing impairment (OR 2.18) and vision impairment alone (OR 2.09), had a stronger association (OR 2.80) with dementia. The findings show the importance of hearing and vision impairment, in particular their combined occurrence, for dementia prevalence in an old population.


Assuntos
Disfunção Cognitiva , Surdez , Demência , Perda Auditiva , Baixa Visão , Idoso de 80 Anos ou mais , Cegueira/complicações , Disfunção Cognitiva/complicações , Disfunção Cognitiva/epidemiologia , Estudos Transversais , Surdez/complicações , Demência/complicações , Perda Auditiva/complicações , Perda Auditiva/epidemiologia , Humanos , Baixa Visão/epidemiologia
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