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2.
Eur Arch Otorhinolaryngol ; 276(11): 3089-3094, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31463602

RESUMO

PURPOSE: To assess preoperative features that could predict the audiological outcome after cochlear implantation in the elderly, in terms of pure tone audiometry, speech audiometry, and speech perception performance. METHODS: All available records of patients with cochlear implants aged 65 or more at the time of their implantation at our Institution were reviewed (50 patients, mean age 70.76 ± 4.03 years), recording preoperative clinical features. Pure tone audiometry, speech audiometry, and speech perception performance 1 year after cochlear implant activation and fitting were used as outcome measures. RESULTS: No statistically significant association emerged between clinical features and pure tone audiometry. On univariate analysis, progressive sensorineural hearing loss of unknown origin was associated with a better outcome in terms of speech audiometry and speech perception performance (p = 0.035 and p = 0.033, respectively). On multivariate analysis, progressive sensorineural hearing loss retained its independent prognostic significance in terms of speech perception performance (p = 0.042). The discriminatory power of a two-variable panel (age and etiology of hearing loss) featured an AUC (ROC) of 0.738 (an acceptable discriminatory power according to the Hosmer-Lemeshow scale). CONCLUSIONS: A progressive sensorineural hearing loss of unknown origin was associated with a better outcome in terms of speech perception in the elderly in our case study. Further features that can predict audiological outcome achievable with cochlear implants in the elderly are desirable to perform adequate counselling and rehabilitation programs.


Assuntos
Audiometria de Tons Puros/métodos , Audiometria da Fala/métodos , Implante Coclear , Perda Auditiva Neurossensorial , Perda Auditiva , Idoso , Implante Coclear/efeitos adversos , Implante Coclear/métodos , Implante Coclear/estatística & dados numéricos , Feminino , Perda Auditiva/classificação , Perda Auditiva/diagnóstico , Perda Auditiva/fisiopatologia , Perda Auditiva/cirurgia , Perda Auditiva Neurossensorial/diagnóstico , Perda Auditiva Neurossensorial/fisiopatologia , Perda Auditiva Neurossensorial/cirurgia , Humanos , Masculino , Avaliação de Processos e Resultados em Cuidados de Saúde , Valor Preditivo dos Testes , Prognóstico , Percepção da Fala
3.
Rev. logop. foniatr. audiol. (Ed. impr.) ; 39(2): 95-100, abr.-jun. 2019.
Artigo em Espanhol | IBECS | ID: ibc-185746

RESUMO

Según la Organización Mundial de la Salud en el mundo hay 360 millones de personas que sufren algún tipo de pérdida auditiva discapacitante. Actualmente los tratamientos más usados para la rehabilitación de hipoacusias neurosensoriales son los aparatos electrónicos como audífonos o dispositivos implantables, tanto cocleares como osteointegrados. La presente revisión resume los avances que se han producido en la rehabilitación auditiva con células madre, y cómo éstas contribuyen en la generación de nuevas células ciliadas y neuronas auditivas. También se revisa el uso combinado con implantes cocleares, y cómo este último ayuda a la creación de redes entre las células ciliadas y las neuronas auditivas. Si bien queda un largo camino por recorrer y poder resolver algunos problemas como la implantación en la cóclea o ganglio espiral de las células o neuronas creadas exógenamente, este tipo de terapia abre una solución para una rehabilitación auditiva que en muchos casos supondría la solución definitiva para la discapacidad auditiva


There are 360 million people who suffers some kind of Hearing loss disability according to the World Health Organization (WHO). Currently, the electronic devices such as hearing aids or implantable devices both cochlear and osseointegrated, are the most useful treatments to hearing loss rehabilitation. The following review summarized both the advances that have occurred in the auditory rehabilitation with stem cells, and how they have helped in the generation of new hair cells and auditory neurons. Besides, both the combined use with cochlear implants and how it helps to create networks between the hair cells and the auditory neuron was reviewed. Although, there is a long way to go and solving some problems, such as implantation in the wall or the spiral ganglion of cells or neurons created exogenously, this kind of therapy opens a solution for a rehabilitation which would be the solution definitive for hearing impairment


Assuntos
Humanos , Transplante de Células-Tronco/métodos , Perda Auditiva/terapia , Doenças do Labirinto/complicações , Perda Auditiva/classificação , Perda Auditiva Neurossensorial/reabilitação , Resultado do Tratamento
4.
Pediatr Blood Cancer ; 66(1): e27457, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-30207054

RESUMO

BACKGROUND: Sickle cell disease (SCD) may cause injury to any organ, including the auditory system. Although the association of SCD and hearing loss has been described, the nature of this complication is unknown. We sought to establish the prevalence and nature of hearing loss in a referred cohort of children with SCD and to identify correlating disease- or treatment-associated factors. PROCEDURE: We conducted a retrospective review of patients with SCD < 22 years of age who had hearing evaluations between August 1990 and December 2014. Demographics, audiograms, and disease and treatment variables were analyzed. RESULTS: Two hundred and ten audiograms among 81 patients were reviewed, and 189 were evaluable. Seventy-two children constituted the referred cohort. Fourteen (19.4%) had hearing loss documented on at least one audiogram. Seven (9.7%) patients had only conductive hearing loss, and the loss persisted for up to 10.3 years. The median age of first identification was eight years. Six (8.3%) patients had hearing loss that was at least partially sensorineural. One patient's hearing loss was ambiguous. All sensorineural hearing losses were unilateral and 4/6 patients had prior documented normal hearing, indicating acquired loss. No correlations were identified. CONCLUSIONS: Both conductive and sensorineural hearing losses are more prevalent in our study population than those observed in the general pediatric population. In children with SCD, sensorineural hearing loss appears to be acquired and unilateral. Conductive hearing loss was identified in older children and can persist. Serial screening is needed for early detection and more prompt intervention in this population.


Assuntos
Anemia Falciforme/complicações , Perda Auditiva/classificação , Perda Auditiva/epidemiologia , Adolescente , Adulto , Audiometria , Criança , Pré-Escolar , Feminino , Seguimentos , Perda Auditiva/etiologia , Humanos , Lactente , Recém-Nascido , Masculino , Missouri/epidemiologia , Prevalência , Prognóstico , Estudos Retrospectivos , Adulto Jovem
5.
Pediatr. aten. prim ; 20(80): e121-e143, oct.-dic. 2018. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-180975

RESUMO

El proceso por el que aprendemos y desarrollamos el lenguaje de forma natural es a través de la audición. La hipoacusia en la primera infancia limitará los estímulos auditivos y afectará significativamente al desarrollo del lenguaje y el habla, además de restringir el vínculo con el mundo que nos rodea. En los lactantes y niños pequeños, la detección y el tratamiento precoces de la hipoacusia pueden mejorar los resultados lingüísticos y escolares. En ausencia de cribado, la edad media a la que se confirma el diagnóstico de hipoacusia congénita en niños sin factores de riesgo está en torno a los 2-3 años. Los programas de cribado auditivo neonatal universal se han extendido ampliamente a pesar de la falta de pruebas sólidas que avalen su eficacia y coste-efectividad. En el presente trabajo, que se ha dividido en dos partes, el autor expone el tema de forma exhaustiva, con sus controversias y claroscuros, para finalmente pronunciarse sobre recomendaciones que el grupo PrevInfad ha consensuado para la consulta de los pediatras en Atención Primaria


The process of learning and developing our language in a natural way is through hearing. Infancy hearing loss will limit auditory stimuli and will significantly harm language and speech development and will narrow the bonds with the world around. In infants and small children, early hearing loss detection and treatment can improve language and school performance. In the absence of screening, medium age of congenital hearing loss diagnosis in children without risk factors is around 2-3 years. Universal new-born hearing screening has spread widely despite the lack of solid evidence supporting its effectivity and cost- efficiency. In this paper, that has been divided in two parts, the author thoroughly describes the topic, with its controversy and nuances, and finally declares on the recommendations that PrevInfad group have agreed for primary care paediatricians


Assuntos
Humanos , Recém-Nascido , Triagem Neonatal/métodos , Perda Auditiva/diagnóstico , Surdez/diagnóstico , Testes Auditivos/estatística & dados numéricos , Perda Auditiva/classificação , Surdez/epidemiologia , Distúrbios da Fala/prevenção & controle , Transtornos da Linguagem/prevenção & controle , Fatores de Risco
6.
Trends Hear ; 22: 2331216518807400, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30384803

RESUMO

Pure-tone audiometry still represents the main measure to characterize individual hearing loss and the basis for hearing-aid fitting. However, the perceptual consequences of hearing loss are typically associated not only with a loss of sensitivity but also with a loss of clarity that is not captured by the audiogram. A detailed characterization of a hearing loss may be complex and needs to be simplified to efficiently explore the specific compensation needs of the individual listener. Here, it is hypothesized that any listener's hearing profile can be characterized along two dimensions of distortion: Type I and Type II. While Type I can be linked to factors affecting audibility, Type II reflects non-audibility-related distortions. To test this hypothesis, the individual performance data from two previous studies were reanalyzed using an unsupervised-learning technique to identify extreme patterns in the data, thus forming the basis for different auditory profiles. Next, a decision tree was determined to classify the listeners into one of the profiles. The analysis provides evidence for the existence of four profiles in the data. The most significant predictors for profile identification were related to binaural processing, auditory nonlinearity, and speech-in-noise perception. This approach could be valuable for analyzing other data sets to select the most relevant tests for auditory profiling and propose more efficient hearing-deficit compensation strategies.


Assuntos
Percepção Auditiva , Perda Auditiva/diagnóstico , Testes Auditivos/métodos , Audição , Pessoas com Deficiência Auditiva/psicologia , Estimulação Acústica , Audiometria de Tons Puros , Limiar Auditivo , Estudos de Casos e Controles , Técnicas de Apoio para a Decisão , Árvores de Decisões , Perda Auditiva/classificação , Perda Auditiva/fisiopatologia , Perda Auditiva/psicologia , Testes Auditivos/estatística & dados numéricos , Humanos , Ruído/efeitos adversos , Mascaramento Perceptivo , Valor Preditivo dos Testes , Percepção da Fala , Teste do Limiar de Recepção da Fala , Aprendizado de Máquina não Supervisionado
7.
Otol Neurotol ; 39(9): e849-e855, 2018 10.
Artigo em Inglês | MEDLINE | ID: mdl-30199501

RESUMO

OBJECTIVES: To highlight superior semicircular canal dehiscence (SSCD) involving the superior petrosal sinus (SPS), and to propose a novel classification system for SPS associated SSCD with potential surgical implications. STUDY DESIGN: Multicenter retrospective review. SETTING: Three tertiary referral centers. PATIENTS: All patients diagnosed with SPS associated SSCD (1/2000 to 8/2016). Radiographic findings and clinical symptoms were analyzed. INTERVENTION: Surgical repair or observation. MAIN OUTCOME MEASURE: Radiographic findings and clinical symptoms were analyzed. RESULTS: Thirty-three dehiscences (30 patients) involving the SPS were identified. The average age at the time of presentation was 52.5 years (median, 56.9; range, 4.9-75.3 yr), and 53.3% of patients were men. Three patients had bilateral SPS associated SSCD. The most common associated symptoms at presentation were episodic vertigo (63.6%), subjective hearing loss (60.6%), and aural fullness (57.6%). Four distinct types of dehiscence were identified: class Ia. SSCD involving a single dehiscence into an otherwise normal appearing SPS; class Ib. SSCD involving a single dehiscence into an apparent venous anomaly of the SPS; class IIa. SSCD involving two distinct dehiscences into the middle cranial fossa and the SPS; class IIb. SSCD involving a single confluent dehiscence into the middle cranial fossa and the SPS. CONCLUSIONS: SSCD involving the SPS represents a small but distinct subset of SSCD cases. This scenario can create a unique set of symptoms and surgical challenges when intervention is sought. Clinical findings and considerations for surgical intervention are provided to facilitate effective diagnosis and management.


Assuntos
Cavidades Cranianas/diagnóstico por imagem , Perda Auditiva/classificação , Doenças do Labirinto/classificação , Canais Semicirculares/diagnóstico por imagem , Adolescente , Adulto , Idoso , Criança , Pré-Escolar , Cavidades Cranianas/cirurgia , Feminino , Perda Auditiva/diagnóstico por imagem , Perda Auditiva/cirurgia , Humanos , Doenças do Labirinto/diagnóstico por imagem , Doenças do Labirinto/cirurgia , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Canais Semicirculares/cirurgia , Adulto Jovem
10.
J Speech Lang Hear Res ; 60(4): 1076-1087, 2017 04 14.
Artigo em Inglês | MEDLINE | ID: mdl-28384694

RESUMO

Purpose: The purpose of this study was to describe the auditory phenotype of a large cohort with Smith-Magenis syndrome (SMS), a rare disorder including physical anomalies, cognitive deficits, sleep disturbances, and a distinct behavioral phenotype. Method: Hearing-related data were collected for 133 individuals with SMS aged 1-49 years. Audiogram data (97 participants) were used for cross-sectional and longitudinal analyses. Caregivers completed a sound sensitivity survey for 98 individuals with SMS and a control group of 24 unaffected siblings. Results: Nearly 80% of participants with interpretable audiograms (n = 76) had hearing loss, which was typically slight to mild in degree. When hearing loss type could be determined (40 participants), sensorineural hearing loss (48.1%) occurred most often in participants aged 11-49 years. Conductive hearing loss (35.2%) was typically observed in children aged 1-10 years. A pattern of fluctuating and progressive hearing decline was documented. Hyperacusis was reported in 73.5% of participants with SMS compared with 12.5% of unaffected siblings. Conclusions: This study offers the most comprehensive characterization of the auditory phenotype of SMS to date. The auditory profile in SMS is multifaceted and can include a previously unreported manifestation of hyperacusis. Routine audiologic surveillance is recommended as part of standard clinical care.


Assuntos
Audição , Síndrome de Smith-Magenis/fisiopatologia , Adolescente , Adulto , Audiometria , Criança , Pré-Escolar , Estudos Transversais , Feminino , Perda Auditiva/classificação , Perda Auditiva/genética , Perda Auditiva/fisiopatologia , Humanos , Hiperacusia/genética , Hiperacusia/fisiopatologia , Lactente , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Fenótipo , Estudos Prospectivos , Estudos Retrospectivos , Irmãos , Síndrome de Smith-Magenis/classificação , Síndrome de Smith-Magenis/genética , Inquéritos e Questionários , Adulto Jovem
12.
Santiago; Chile. Ministerio de Salud. División de Planificación Sanitaria; 2017.
Monografia em Espanhol | BIGG | ID: biblio-967241

RESUMO

Objetivo general: Generar recomendaciones basadas en la mejor evidencia disponible acerca de prevención, tratamiento y rehabilitación de la hipoacusia bilateral neurosensorial en recién nacidos y niños menores de 4 años


Assuntos
Humanos , Recém-Nascido , Perda Auditiva Neurossensorial , Perda Auditiva Neurossensorial/diagnóstico , Perda Auditiva Neurossensorial/terapia , Recém-Nascido Prematuro , Perda Auditiva/classificação
13.
Int J Audiol ; 55(2): 65-74, 2016.
Artigo em Inglês | MEDLINE | ID: mdl-26618898

RESUMO

OBJECTIVE: Drug-mediated ototoxicity, specifically cochleotoxicity, is a concern for patients receiving medications for the treatment of serious illness. A number of classification schemes exist, most of which are based on pure-tone audiometry, in order to assist non-audiological/non-otological specialists in the identification and monitoring of iatrogenic hearing loss. This review identifies the primary classification systems used in cochleototoxicity monitoring. By bringing together classifications published in discipline-specific literature, the paper aims to increase awareness of their relative strengths and limitations in the assessment and monitoring of ototoxic hearing loss and to indicate how future classification systems may improve upon the status-quo. DESIGN: Literature review. STUDY SAMPLE: PubMed identified 4878 articles containing the search term ototox*. RESULTS: A systematic search identified 13 key classification systems. Cochleotoxicity classification systems can be divided into those which focus on hearing change from a baseline audiogram and those that focus on the functional impact of the hearing loss. CONCLUSIONS: Common weaknesses of these grading scales included a lack of sensitivity to small adverse changes in hearing thresholds, a lack of high-frequency audiometry (>8 kHz), and lack of indication of which changes are likely to be clinically significant for communication and quality of life.


Assuntos
Perda Auditiva/induzido quimicamente , Perda Auditiva/classificação , Audiometria , Limiar Auditivo , Humanos , Emissões Otoacústicas Espontâneas
14.
Otolaryngol Clin North Am ; 48(6): 933-53, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26452421

RESUMO

Hearing loss is the most common congenital sensory impairment. According to National Health and Nutrition Examination Survey data from 2001 to 2008, 20.3% of subjects aged greater than or equal to 12 had unilateral or bilateral hearing loss. The World Health Organization notes that, worldwide, there are 360 million people with disabling hearing loss, with 50% preventable. Although many hearing losses are acquired, many others are manifestations of preexisting conditions. The purpose of a pediatric hearing evaluation is to identify the degree and type of hearing loss and etiology and to outline a comprehensive strategy that supports language and social development and communication.


Assuntos
Orelha Interna/anormalidades , Orelha Média/anormalidades , Perda Auditiva/classificação , Perda Auditiva/etiologia , Perda Auditiva/prevenção & controle , Criança , Infecções por Citomegalovirus/complicações , Infecções por HIV/complicações , Traumatismos Cranianos Fechados , Herpes Simples/complicações , Humanos , Hiperbilirrubinemia/complicações , Ruído/efeitos adversos , Inquéritos Nutricionais , Rubéola (Sarampo Alemão)/complicações , Sífilis/complicações , Toxoplasmose/complicações
15.
Otolaryngol Clin North Am ; 48(6): 913-32, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26409820

RESUMO

Computed tomography (CT) and MRI have become an integral part of the evaluation of children with hearing loss. Abnormalities on CT or MRI are found in 20% to 50% of children with sensorineural hearing loss and correlate with the degree of hearing loss. CT and MRI have distinct advantages and disadvantages in imaging the middle and inner ear. The timing of radiographic imaging is an important consideration. This article reviews radiographic abnormalities associated with sensorineural, mixed, and conductive hearing losses in children and offers guidance about the proper utilization of imaging studies.


Assuntos
Cóclea/diagnóstico por imagem , Fraturas Ósseas/diagnóstico por imagem , Perda Auditiva/diagnóstico , Osso Temporal/diagnóstico por imagem , Aqueduto Vestibular/diagnóstico por imagem , Criança , Cóclea/patologia , Perda Auditiva/classificação , Humanos , Imagem por Ressonância Magnética , Tomografia Computadorizada por Raios X
16.
Otolaryngol Clin North Am ; 48(6): 891-901, 2015 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-26388609

RESUMO

This article provides the reader with basic knowledge regarding the measurement tools needed to assess hearing in children. The test batteries described here are adaptable and interchangeable to meet the needs of the entire pediatric population no matter what the age or developmental stage. It is meant to provide the team of professionals involved in the treatment of pediatric hearing disorders with a framework from which the process of diagnosis, treatment, and rehabilitation can begin at an early age.


Assuntos
Audiometria/métodos , Diagnóstico Precoce , Perda Auditiva/classificação , Perda Auditiva/diagnóstico , Criança , Perda Auditiva/terapia , Humanos , Emissões Otoacústicas Espontâneas , Percepção da Fala
18.
N Z Med J ; 127(1398): 98-110, 2014 Jul 18.
Artigo em Inglês | MEDLINE | ID: mdl-25146865

RESUMO

AIM: This study was undertaken to determine if young Maori have more permanent bilateral hearing loss, or less severe and profound hearing loss than New Zealand (NZ) Europeans. METHODS: Data include hearing-impaired children from birth to 19 years of age from the New Zealand Deafness Notification Database (DND) and covering the periods 1982-2005 and 2009-2013. These were retrospectively analysed, as was information on children and young people with cochlear implants. RESULTS: Young Maori are more likely to be diagnosed with permanent hearing loss greater than 26 dB HL, averaged across speech frequencies, with 39-43% of hearing loss notifications listed as Maori. Maori have a lower prevalence of severe/profound losses (n=1571, chi squared=22.08, p=0.01) but significantly more bilateral losses than their NZ European peers (n=595, Chi-squared=9.05, p=0.01). The difference in severity profile is supported by cochlear implant data showing Maori are less likely to receive a cochlear implant. CONCLUSIONS: There are significant differences in the proportion of bilateral (compared to unilateral) losses and in the rates and severity profile of hearing loss among young Maori when compared with their NZ European peers. This has implications for screening and other hearing services in NZ.


Assuntos
Grupo com Ancestrais do Continente Europeu , Perda Auditiva/etnologia , Grupo com Ancestrais Oceânicos , Adolescente , Distribuição de Qui-Quadrado , Criança , Pré-Escolar , Implantes Cocleares , Perda Auditiva/classificação , Humanos , Lactente , Recém-Nascido , Nova Zelândia/epidemiologia , Estudos Retrospectivos , Índice de Gravidade de Doença , Adulto Jovem
20.
Clin Genet ; 85(6): 514-23, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-24547994

RESUMO

Hearing impairment is an extremely heterogeneous disorder, with both environmental as well as genetic causes. This review describes the known genes involved in non-syndromic hearing impairment and their genotype-phenotype correlations where possible. Furthermore, some of the more frequent syndromic forms of hearing impairment are described, in particular where they overlap with the non-syndromic forms. Given the heterogeneity of the disorder, together with the indistinguishable phenotypes for many of the genes, it is suggested that testing for mutations is performed using massive parallel sequencing techniques, either by a large targeted set of genes or by an exome wide analysis.


Assuntos
Proteínas Adaptadoras de Transdução de Sinal/genética , Perda Auditiva/genética , Canais Iônicos/genética , Audiometria , Estudos de Associação Genética , Loci Gênicos , Genótipo , Perda Auditiva/classificação , Perda Auditiva/diagnóstico , Perda Auditiva/patologia , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , Mutação , Fenótipo
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