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3.
BMJ Case Rep ; 14(4)2021 Apr 02.
Artigo em Inglês | MEDLINE | ID: mdl-33811095

RESUMO

Chronic otorrhoea from a tympanic membrane perforation is common. We present the case of a patient who had already received seemingly adequate treatment for his condition in the past. Yet, he presented to our outpatient clinic with worsening otalgia and otorrhoea, progressive hearing loss and a new tympanic membrane perforation. After a thorough otological evaluation, the patient's medical history and the histological specimen from a previous operation were reviewed. The findings met the diagnostic criteria of eosinophilic otitis media. After treatment with topic triamcinolone through the perforated tympanic membrane, the patient's otalgia subsided, hearing levels were improved and the size of the tympanic membrane perforation decreased.


Assuntos
Perda Auditiva , Otite Média Supurativa , Otite Média , Perfuração da Membrana Timpânica , Timpanoplastia , Antibacterianos/uso terapêutico , Doença Crônica , Dor de Orelha/etiologia , Perda Auditiva/tratamento farmacológico , Perda Auditiva/etiologia , Humanos , Masculino , Pessoa de Meia-Idade , Otite Média/tratamento farmacológico , Otite Média Supurativa/complicações , Otite Média Supurativa/tratamento farmacológico , Otite Média Supurativa/cirurgia , Resultado do Tratamento , Perfuração da Membrana Timpânica/tratamento farmacológico , Perfuração da Membrana Timpânica/cirurgia
6.
Int J Mol Sci ; 22(8)2021 Apr 10.
Artigo em Inglês | MEDLINE | ID: mdl-33920085

RESUMO

Hearing loss is the most common sensory disorder with ~466 million people worldwide affected, representing about 5% of the population. A substantial portion of hearing loss is genetic. Hearing loss can either be non-syndromic, if hearing loss is the only clinical manifestation, or syndromic, if the hearing loss is accompanied by a collage of other clinical manifestations. Usher syndrome is a syndromic form of genetic hearing loss that is accompanied by impaired vision associated with retinitis pigmentosa and, in many cases, vestibular dysfunction. It is the most common cause of deaf-blindness. Currently cochlear implantation or hearing aids are the only treatments for Usher-related hearing loss. However, gene therapy has shown promise in treating Usher-related retinitis pigmentosa. Here we review how the etiologies of Usher-related hearing loss make it a good candidate for gene therapy and discuss how various forms of gene therapy could be applied to Usher-related hearing loss.


Assuntos
Orelha Interna/patologia , Terapia Genética , Perda Auditiva/terapia , Retinite Pigmentosa/terapia , Síndromes de Usher/terapia , Orelha Interna/crescimento & desenvolvimento , Perda Auditiva/etiologia , Perda Auditiva/genética , Perda Auditiva/patologia , Humanos , Mutação/genética , Retinite Pigmentosa/genética , Retinite Pigmentosa/patologia , Síndromes de Usher/etiologia , Síndromes de Usher/genética , Síndromes de Usher/patologia
7.
Recurso na Internet em Português | LIS - Localizador de Informação em Saúde | ID: lis-48066

RESUMO

Quase 2,5 bilhões de pessoas em todo o mundo ─ ou uma cada quatro pessoas ─ viverão com algum grau de perda auditiva até 2050, adverte o primeiro Relatório Mundial sobre Audição da Organização Mundial da Saúde (OMS), divulgado nesta terça-feira (2).


Assuntos
Perda Auditiva/etiologia , Organização Mundial da Saúde , Audição
8.
N Engl J Med ; 384(6): 521-532, 2021 02 11.
Artigo em Inglês | MEDLINE | ID: mdl-33567192

RESUMO

BACKGROUND: Bilateral vestibular hypofunction is associated with chronic disequilibrium, postural instability, and unsteady gait owing to failure of vestibular reflexes that stabilize the eyes, head, and body. A vestibular implant may be effective in alleviating symptoms. METHODS: Persons who had had ototoxic (7 participants) or idiopathic (1 participant) bilateral vestibular hypofunction for 2 to 23 years underwent unilateral implantation of a prosthesis that electrically stimulates the three semicircular canal branches of the vestibular nerve. Clinical outcomes included the score on the Bruininks-Oseretsky Test of Motor Proficiency balance subtest (range, 0 to 36, with higher scores indicating better balance), time to failure on the modified Romberg test (range, 0 to 30 seconds), score on the Dynamic Gait Index (range, 0 to 24, with higher scores indicating better gait performance), time needed to complete the Timed Up and Go test, gait speed, pure-tone auditory detection thresholds, speech discrimination scores, and quality of life. We compared participants' results at baseline (before implantation) with those at 6 months (8 participants) and at 1 year (6 participants) with the device set in its usual treatment mode (varying stimulus pulse rate and amplitude to represent rotational head motion) and in a placebo mode (holding pulse rate and amplitude constant). RESULTS: The median scores at baseline and at 6 months on the Bruininks-Oseretsky test were 17.5 and 21.0, respectively (median within-participant difference, 5.5 points; 95% confidence interval [CI], 0 to 10.0); the median times on the modified Romberg test were 3.6 seconds and 8.3 seconds (difference, 5.1; 95% CI, 1.5 to 27.6); the median scores on the Dynamic Gait Index were 12.5 and 22.5 (difference, 10.5 points; 95% CI, 1.5 to 12.0); the median times on the Timed Up and Go test were 11.0 seconds and 8.7 seconds (difference, 2.3; 95% CI, -1.7 to 5.0); and the median speeds on the gait-speed test were 1.03 m per second and 1.10 m per second (difference, 0.13; 95% CI, -0.25 to 0.30). Placebo-mode testing confirmed that improvements were due to treatment-mode stimulation. Among the 6 participants who were also assessed at 1 year, the median within-participant changes from baseline to 1 year were generally consistent with results at 6 months. Implantation caused ipsilateral hearing loss, with the air-conducted pure-tone average detection threshold at 6 months increasing by 3 to 16 dB in 5 participants and by 74 to 104 dB in 3 participants. Changes in participant-reported disability and quality of life paralleled changes in posture and gait. CONCLUSIONS: Six months and 1 year after unilateral implantation of a vestibular prosthesis for bilateral vestibular hypofunction, measures of posture, gait, and quality of life were generally in the direction of improvement from baseline, but hearing was reduced in the ear with the implant in all but 1 participant. (Funded by the National Institutes of Health and others; ClinicalTrials.gov number, NCT02725463.).


Assuntos
Vestibulopatia Bilateral/cirurgia , Marcha/fisiologia , Perda Auditiva/etiologia , Neuroestimuladores Implantáveis , Equilíbrio Postural/fisiologia , Qualidade de Vida , Vestíbulo do Labirinto/cirurgia , Idoso , Vestibulopatia Bilateral/induzido quimicamente , Vestibulopatia Bilateral/complicações , Tontura/etiologia , Feminino , Transtornos Neurológicos da Marcha/etiologia , Humanos , Neuroestimuladores Implantáveis/efeitos adversos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias , Estudos Prospectivos , Canais Semicirculares/inervação , Nervo Vestibular/efeitos dos fármacos
9.
Medicine (Baltimore) ; 100(3): e24056, 2021 Jan 22.
Artigo em Inglês | MEDLINE | ID: mdl-33546006

RESUMO

ABSTRACT: Few epidemiological studies have examined the relationship between earphone usage and hearing loss in adolescents. This study identified the prevalence of hearing loss in South Korean adolescents using representative national survey data and evaluated the relationship between earphone usage in a noisy environment and hearing loss. This study analyzed 532 subjects (12-19 years) who participated in a 2012 national survey and completed health and noise environment exposure questionnaires and pure tone audiometry (PTA) test. Hearing loss was defined as an average hearing threshold of 26 Decibel-A (dBA) or higher in PTA. The relationship between earphone usage and hearing loss was analyzed using a hierarchical logistic regression model. Adolescents who were exposed to high noise levels via headphones in a noisy environment had a hearing loss prevalence of 22.6% and adolescents who used earphones 80 minutes or more per day on average had the hearing loss prevalence of 22.3%. The results of the logistic regression analysis revealed that adolescents who used earphones in a noisy environment had a 4.5-fold higher risk of hearing loss and an 8.4 times higher risk of having a subjective hearing problem than those who did not use earphones (prevalence odds ratio (pOR) = 4.54, 95% confidence interval (CI): 1.35-15.24; pOR = 8.39, 95% CI: 1.12-62.83, respectively). Additionally, adolescents who used earphones more than 80 minutes per day in a noisy environment had a 4.7 times higher risk of hearing loss than those who used them less than 80 minutes per day (pOR = 4.68, 95% CI: 1.08-20.22). Longitudinal studies are needed to provide evidence of causality between earphone usage and hearing loss.


Assuntos
Dispositivos de Proteção das Orelhas/estatística & dados numéricos , Exposição Ambiental/análise , Perda Auditiva/epidemiologia , Ruído/efeitos adversos , Estudantes/estatística & dados numéricos , Adolescente , Audiometria de Tons Puros , Limiar Auditivo , Criança , Exposição Ambiental/efeitos adversos , Feminino , Perda Auditiva/etiologia , Humanos , Modelos Logísticos , Masculino , Razão de Chances , Prevalência , República da Coreia/epidemiologia , Autorrelato , Fatores de Tempo , Adulto Jovem
10.
Otol Neurotol ; 42(3): 351-362, 2021 03 01.
Artigo em Inglês | MEDLINE | ID: mdl-33555742

RESUMO

OBJECTIVE: To perform a systematic review and meta-analysis summarizing the current evidence on the management of intracanalicular vestibular schwannoma. DATA SOURCES: Embase (1947-), Medline (1946-), Cochrane library (1947-), Scopus (2010-), and CINAHL (1961-) were searched from 1969 to October 5, 2019 (50 years). STUDY SELECTION: A search strategy was performed to identify patients with vestibular schwannoma confined to the internal auditory canal without extension to the cerebellopontine angle. Studies with patients aged less than 18, Neurofibromatosis type 2, revision cases, and non-English language were excluded. DATA EXTRACTION: A standardized collection sheet was used for the extracted data and a quality assessment was performed using the Newcastle-Ottawa Scale with the comparability criterion omitted. DATA SYNTHESIS: Seventy-one studies were included with 24 on observation, 14 on radiotherapy, and 34 on surgery. The primary outcome was serviceable hearing preservation. Secondary outcomes were preservation of facial nerve function, growth, involution, and dizziness. Sub-analysis on the type of surgery and type of radiotherapy were performed. Excel 2016 with MIX 2.0 Pro add-on package was used to analyze the data and create forest plots. Data were presented in proportion with a 95% confidence interval. CONCLUSIONS: Serviceable hearing was observed in 31% of patients after observation, 56% after radiotherapy, and 51% after surgical treatment with mean follow-up time of 4.04 years, 4.92 years, and 2.23 years, respectively. Facial nerve function was found to be best preserved in both observation and radiotherapy groups. Vestibular schwannoma growth occurred in 33% of patients under observation. Involution occurred in 2% of patients under observation and in 38% after radiotherapy.


Assuntos
Perda Auditiva , Neuroma Acústico , Radiocirurgia , Idoso , Audição , Perda Auditiva/etiologia , Testes Auditivos , Humanos , Neuroma Acústico/radioterapia , Neuroma Acústico/cirurgia , Resultado do Tratamento
11.
Otol Neurotol ; 42(3): e286-e293, 2021 03 01.
Artigo em Inglês | MEDLINE | ID: mdl-33555749

RESUMO

HYPOTHESIS: Animals with cochlear implantation-induced hearing loss will have a lower endocochlear potential (EP) and decreased strial vascular density. BACKGROUND: The cause of residual hearing loss following cochlear implantation remains poorly understood. Recent work from our lab has shown a correlation between vascular changes in the cochlear lateral wall and postimplantation hearing loss, suggesting a role of the stria vascularis and EP. METHODS: Fourteen young, normal-hearing male albino guinea pigs underwent cochlear implantation using either a cochleostomy (CI-c, n = 9) or an extended round window (CI-eRW, n = 5) approach. Hearing sensitivity was assessed pre- and postoperatively using auditory brainstem response thresholds. Three weeks after implantation, EP measurements were obtained from the first and second turns. Hair cell counts and stria vascularis capillary density measurements were also obtained. RESULTS: The implanted group experienced significant threshold elevations at 8 to 24 kHz (mean threshold shift 9.1 ±â€Š1.1 dB), with a more robust threshold shift observed in the CI-eRW group compared to the CI-c group. Implanted animals had a significantly lower first turn EP (81.4 ±â€Š5.1 mV) compared with controls (87.9 ±â€Š6.1 mV). No differences were observed in the second turn (75.8 ±â€Š12.0 mV for implanted animals compared to 76.5 ±â€Š7.0 mV for controls). There were no significant correlations between turn-specific threshold shifts, EP measurements, or strial blood vessel density. CONCLUSIONS: Reliable EP measurements can be obtained in chronically implanted guinea pigs. Hearing loss after implantation is not explained by changes in strial vascular density or reductions in EP.


Assuntos
Implante Coclear , Perda Auditiva , Animais , Cóclea , Cobaias , Audição , Perda Auditiva/etiologia , Masculino , Estria Vascular
12.
Acta otorrinolaringol. esp ; 72(1): 37-50, ene.-feb. 2021. tab
Artigo em Espanhol | IBECS | ID: ibc-200347

RESUMO

ANTECEDENTES Y OBJETIVO: En 2003, el Ministerio de Sanidad y Consumo, junto con las comunidades autónomas (CCAA), aprobaron el documento sobre los contenidos básicos y mínimos para el establecimiento de Programas de detección precoz de la sordera, y desde entonces la Comisión para la detección precoz de la hipoacusia (CODEPEH) ha llevado a cabo varias actualizaciones y recomendaciones de mejora de estos programas. El objetivo de este trabajo es realizar un estudio comparativo de cómo han plasmado las CCAA, en sus Programas de detección precoz de la sordera, las recomendaciones realizadas por la CODEPEH hasta 2017. MATERIAL Y MÉTODO: Se han revisado los programas (o documentos afines) de 16 CCAA disponibles en línea o en papel. RESULTADOS: Las 16 estrategias de detección precoz analizadas son diferentes, ya sea en el número de pruebas a realizar, ya sea en los tiempos en los que se llevan a cabo o las técnicas empleadas. Más de un tercio de estos programas fueron editados antes del 2010 y no han sido actualizados. Las otoemisiones acústicas es la técnica elegida como primera prueba de cribado en 9 de las 16 CCAA. Solo una comunidad incorpora la realización de la prueba de reacción en cadena de la polimerasa en saliva para citomegalovirus en niños con prueba de cribado alterada. CONCLUSIONES: Todas las CCAA realizan cribado auditivo, pero la gran diversidad entre programas dificulta sacar conclusiones fiables sobre el resultado final del mismo y sería necesario tender a una unificación con la elaboración de un programa nacional y una base de datos común


INTRODUCTION AND OBJECTIVE: In 2003, The Ministry of Health and Consumption, together with the Autonomous Communities (CCAA), approved a minimum and basic document concerning the establishment of Early Hearing Detection and Intervention State Programmes. Since then, the Commission for the early detection of hearing loss (CODEPEH) has made several updates and recommendations to improve these programmes. The objective of this study is to carry out a comparative analysis of how the CCAA established their Early Hearing Detection and Intervention programs and if they integrate the recommendations made by CODEPEH until 2017. MATERIAL AND METHOD: The programmes (or related documents) of 16 CCAA available on line or paper are reviewed. RESULTS: The 16 Early Hearing Detection and Intervention strategies analyzed are different, either in the number of test to be performed, the time in which they are performed or the techniques used. More than a third of these programmes were published before 2010 and have not been updated. Otoacoustic emissions is the chosen technique as the first screening test in nine of the 16 CCAA. Only one CCAA incorporates the salivary polymerase chain reaction test for cytomegalovirus in children with altered screening test. CONCLUSION: All CCAA perform Early Hearing Detection and Intervention programmes but the heterogeneity does not allow drawing reliable conclusions about the result of the screening process and it would be necessary to aim for unification with the elaboration of a national programme and an integrated general database


Assuntos
Humanos , Pré-Escolar , Criança , Avaliação de Programas e Projetos de Saúde , Diagnóstico Precoce , Perda Auditiva/diagnóstico , Testes Auditivos/métodos , Perda Auditiva/economia , Perda Auditiva/etiologia , Perda Auditiva/reabilitação , Saliva , Reação em Cadeia da Polimerase , Estudos Transversais , Epidemiologia Descritiva , Fatores de Risco
13.
Ulus Travma Acil Cerrahi Derg ; 27(1): 79-84, 2021 01.
Artigo em Inglês | MEDLINE | ID: mdl-33394482

RESUMO

BACKGROUND: Blast-induced hearing loss is an acoustic trauma commonly caused by high-energy explosions of improvised explosive devices, and the auditory system may be affected by blast damage. This study aims to evaluate the protective effect of tympanic membrane perforation (TMP) on the inner ear against blast injury. METHODS: In this study, 43 adult patients who had suffered blast injury were divided into three subgroups: intact tympanic membranes in both ears, unilateral TMP, and bilateral TMP. Each patient underwent a comprehensive audiogram, including bone conduction, in the audiology department. RESULTS: Evaluation was performed on 43 (100%) males with a mean age of 31.44±8.01 years (range, 18-52 years). When the type of hearing loss was evaluated separately for each ear, sensorineural hearing loss (SNHL) was observed in 31 (36%), high-frequency SNHL in 26 (30.2%), conductive hearing loss in eight (9.3%), and mixed type hearing loss in 21 (24.4%) ears. TMP was detected in 21 (48.8%) of 43 blast-injured patients, on the right side in four (9.3%) patients, on the left side in seven (16.3%), and bilateral in 10 (23.3%). When the type of acoustic trauma was evaluated, 15 (34.9%) patients were observed to have suffered from the explosion of an IED, 12 (30.2%) from weapon explosion, six (14%) were a vehicle bomb explosion, three (7%) were projectile missile explosion, three (7%) were mortar explosion, two (4.7%) were mine explosion, and two (4.7%) were exposed to the explosion in an armored vehicle (Table 1). CONCLUSION: No significant difference was observed in the majority of the frequencies whether the tympanic membrane was perforated or not in the blast-injured patients and it was concluded that tympanic membrane perforation caused by blast injury had no protective effect on the inner ear.


Assuntos
Traumatismos por Explosões , Orelha Interna/fisiopatologia , Perda Auditiva , Perfuração da Membrana Timpânica , Adolescente , Adulto , Traumatismos por Explosões/complicações , Traumatismos por Explosões/epidemiologia , Traumatismos por Explosões/fisiopatologia , Perda Auditiva/epidemiologia , Perda Auditiva/etiologia , Humanos , Masculino , Pessoa de Meia-Idade , Perfuração da Membrana Timpânica/epidemiologia , Perfuração da Membrana Timpânica/etiologia , Adulto Jovem
14.
Ecotoxicol Environ Saf ; 211: 111939, 2021 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-33476847

RESUMO

It has been documented that arsenic has a potential risk to human health and identified as a risk factor for hearing impairment. However, there are few studies that confirm the ototoxic effect of arsenic, especially on the human auditory system. Therefore, the current study was conducted to investigate the correlation between auditory thresholds at different frequencies (0.25, 0.5, 1, 2, 4 and 8 kHz) and arsenic levels in drinking water samples. A total of 240 people, divided into two equal groups: exposed and reference, were selected for the auditory tests. It should be noted that, at frequencies from 0.25 to 1 kHz, no hearing loss was observed in the both groups. Based on the results, no significant correlations (p > 0.05) were found between hearing thresholds and confounding variables including gender and BMI. However, smoking and age are known to be the main variables for hearing loss in univariate regression analysis. In the case of age, the hearing loss risk in the older participants was increased compared with the younger participants (4 kHz (OR =1.09; 95% CI: 1.04, 1.13) and 8 kHz (OR =1.12; 95% CI: 1.06, 1.18)). Smoking habits had significant associations with hearing loss risk at 4 kHz (OR = 3.48; 95% CI: 1.47, 8.22) and 8 kHz (OR = 3.01; 95% CI: 1.14, 7.95). The multivariate regression analysis showed that age, smoking status, and exposure to arsenic were significantly associated with increased risk of hearing loss. Moreover, no statistically significant correlation (p˃0.05) was observed between arsenic exposure and hearing loss in the logistic regression model compared to the reference group. These outcomes suggest that further investigation and cohort studies with a larger number of participants should be conducted to find an association between arsenic exposure and hearing loss in general population.


Assuntos
Arsênico/análise , Água Potável/química , Exposição Ambiental/estatística & dados numéricos , Perda Auditiva/epidemiologia , Audição/efeitos dos fármacos , Poluição Química da Água/estatística & dados numéricos , Adolescente , Adulto , Arsênico/toxicidade , Limiar Auditivo , Criança , Estudos de Coortes , Estudos Transversais , Água Potável/análise , Feminino , Perda Auditiva/etiologia , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Fatores de Risco , Fumar , Adulto Jovem
15.
J Pediatr ; 231: 68-73, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33359471

RESUMO

OBJECTIVE: To characterize the association between hyperbilirubinemia and a failed newborn hearing screen in infants born at 22-32 weeks of gestation. STUDY DESIGN: We included infants with gestational ages of 22-32 weeks who were discharged from neonatal intensive care units in the US from 2002 to 2017 with available newborn hearing screen results obtained after 34 weeks postmenstrual age. We excluded infants with severe birth asphyxia or craniofacial abnormalities. We identified 95 672 infants from 313 neonatal intensive care units. We used multivariable logistic regression to examine the association between maximum total bilirubin at <21 days postnatal age with failed hearing screen, adjusting for important demographic and clinical risk factors. RESULTS: The median gestational age and birth weight were 30 weeks (IQR, 28-32 weeks) and 1330 g (IQR, 1010-1630 g), respectively. The median maximum total bilirubin was 8.3 mg/dL (IQR, 6.7-10.0 mg/dL), and 5275 infants (6%) failed their newborn hearing screen. On adjusted analysis, each 1 mg/dL increase in maximum total bilirubin was associated with a small, but significant, increase in odds of a failed hearing screen (OR, 1.03; 95% CI, 1.02-1.04). CONCLUSIONS: An increased maximum total bilirubin level was independently associated with hearing screen failure. Further prospective studies are needed to understand whether this increased risk of hearing screen failure translates to increased risk of hearing loss.


Assuntos
Perda Auditiva/etiologia , Testes Auditivos , Hiperbilirrubinemia/complicações , Doenças do Prematuro/etiologia , Triagem Neonatal , Feminino , Perda Auditiva/diagnóstico , Humanos , Hiperbilirrubinemia/diagnóstico , Recém-Nascido , Recém-Nascido Prematuro , Doenças do Prematuro/diagnóstico , Unidades de Terapia Intensiva Neonatal , Modelos Logísticos , Masculino , Estudos Retrospectivos , Fatores de Risco
16.
J Formos Med Assoc ; 120(1 Pt 1): 107-120, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-32473863

RESUMO

Age-related hearing loss (ARHL) is a major and increasingly prevalent health problem worldwide, causing disability and social isolation in the people who present it. This impairment is caused by genetic and environmental factors. Nutritional status has been identified as a related risk associated with hearing loss (HL). This scoping review aimed to characterize the links between HL and nutritional status. PubMed, Embase, Cochrane and Scopus databases were searched up to December 2019. Studies examining the relation between nutrition and dietary habits and HL were included. After screening 3510 citations, 22 publications were selected for inclusion in the current review, all of which were published between 2010 and 2019. Diets rich in saturated fats and cholesterol have deleterious effects on hearing that could be prevented by lower consumption. Conversely, greater consumption of fruit and vegetables, and of polyunsaturated fatty acids (omega-3) and anti-oxidants in the form of vitamins A, C, and E, prevent the development of ARHL. The current literature suggests a possible association between nutritional status and hearing loss. More studies are needed to better characterize the clinical consequences of this association.


Assuntos
Perda Auditiva , Estado Nutricional , Dieta , Perda Auditiva/etiologia , Perda Auditiva/prevenção & controle , Humanos , Vitamina A , Vitaminas
17.
Otol Neurotol ; 42(4): e425-e432, 2021 04 01.
Artigo em Inglês | MEDLINE | ID: mdl-33351558

RESUMO

OBJECTIVE: To describe outcomes with cochlear implantation (CI) for rehabilitation of hearing loss in patients with sporadic vestibular schwannomas (VS) and other retrocochlear pathologies. STUDY DESIGN: Retrospective review. SETTING: Tertiary-care center. PATIENTS: Twenty three cases in 19 patients (53% men, mean age 55.8 yr) with non-neurofibromatosis type 2 related retrocochlear pathology. INTERVENTIONS: Unilateral or bilateral CI. MAIN OUTCOME MEASURES: Word recognition score, device usage. RESULTS: Etiology of deafness included sporadic VS (n = 9, 39%), radiation after head and neck or central nervous system (CNS) malignancy (n = 8, 35%), superficial siderosis (n = 3, 13%), neurosarcoidosis (n = 2, 9%), and pontine stroke (n = 1, 4%). Mean follow-up duration was 2.3 years (standard deviation [SD] 3.0; range, 0.2-9.4). Auditory perception was achieved in 20 out of 22 patients (91%) who have been activated. Mean WRS in patients with sporadic VS was 18% (SD 20; range, 0-44). Mean WRS in patients with non-VS retrocochlear pathology was 55% (SD 30; range, 0-94). Data logs showed 7.0 h/d of average use (SD 4.3; range, 0-13). CONCLUSIONS: Appropriately selected patients with retrocochlear pathology may benefit from CI so long as the patient has a cochlear fluid signal and an intact cochlear nerve. Patients with sporadic VS patients and normal contralateral hearing exhibited guarded outcomes with CI, whereas most patients with non-VS retrocochlear pathologies demonstrated open-set speech understanding scores comparable to or slightly worse than conventional CI candidates. Since variable performance benefit is observed with CI in patients with retrocochlear pathology, counseling is imperative to align patient expectations with realistic outcomes.


Assuntos
Implante Coclear , Perda Auditiva , Neuroma Acústico , Percepção da Fala , Feminino , Perda Auditiva/etiologia , Humanos , Masculino , Pessoa de Meia-Idade , Neuroma Acústico/complicações , Neuroma Acústico/cirurgia , Estudos Retrospectivos , Resultado do Tratamento
18.
Neurosci Lett ; 740: 135427, 2021 01 01.
Artigo em Inglês | MEDLINE | ID: mdl-33069812

RESUMO

The STAT1 knock-out (KO) mouse is a frequently used transgenic immunodeficient strain to model human viral and bacterial diseases. The Lassa fever model was established in the STAT1 KO mice mimicking phenotypes seen in human patients including deafness in survivors. This model develops hearing loss at high prevalence and is a valuable tool to investigate viral infection-induced hearing loss. However, Lassa virus is a highly contagious and regulated agent requiring the unique logistics of the biosafety level 4 posing limitations for experimental work. Therefore, we did a detailed auditory analysis of the STAT1 KO mice to assess baseline auditory function in preparation for further auditory behavioral studies. Auditory brainstem response and distortion product otoacoustic emission tests were performed on males and females of the STAT1 KO mice and was compared to 129S6/SvEv wild type (WT) mice. The male WT mice had the best auditory performance and the female WT mice had the worst hearing performance. The male and female STAT1 KO mice had similar auditory performance to each other, which was intermediate between WT males and females. We conclude that both male and female STAT1 KO mice are suitable for studying viral infection-induced hearing loss.


Assuntos
Perda Auditiva/genética , Febre Lassa/genética , Fator de Transcrição STAT1/genética , Animais , Comportamento Animal , Modelos Animais de Doenças , Progressão da Doença , Potenciais Evocados Auditivos do Tronco Encefálico , Feminino , Perda Auditiva/etiologia , Perda Auditiva/fisiopatologia , Testes Auditivos , Febre Lassa/fisiopatologia , Masculino , Camundongos , Camundongos Knockout , Camundongos Transgênicos , Emissões Otoacústicas Espontâneas , Caracteres Sexuais
19.
Ned Tijdschr Geneeskd ; 1642020 11 19.
Artigo em Holandês | MEDLINE | ID: mdl-33332038

RESUMO

An Auditory Brainstem Implant (ABI) is a technique developed for patients with severe hearing loss. The ABI consists of a microphone and speech processor located on the scalp, which is connected to a transmitting and receiving coil and electrode on the brain stem placed in the skull. Eligible for an ABI are adults with cochlea and acoustic nerve damage due to neurofibromatosis type 2, and children with congenital malformation or aplasia, cochlear trauma or cochlear ossification after meningitis. An ABI can provide useful hearing. It has proven to be a safe procedure without serious complications. The entire ABI process is handled by a multidisciplinary team with extensive experience in cerebellopontine angle tumour surgery and cochlear implantation in adults and children. Concentration of this care in a specialized centre is important to maximize the chances of a successful outcome.


Assuntos
Implante Auditivo de Tronco Encefálico , Implantes Auditivos de Tronco Encefálico , Perda Auditiva/cirurgia , Adulto , Criança , Feminino , Perda Auditiva/etiologia , Humanos , Masculino , Resultado do Tratamento
20.
Niger J Clin Pract ; 23(11): 1494-1499, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-33221771

RESUMO

Background: Presbyacusis is a cause of hearing loss in adults worldwide. It is a type of auditory dysfunction thought to be due to a series of insults over time including agerelated degeneration, noise exposure, and diseases of the ear. It usually affects the high frequencies of hearing. Presbyacusis has a tremendous impact on the quality of life of millions of the aged and is fast becoming an increasingly prevalent disorder as the population ages. Nigerian population is becoming progressively older making it imperative to focus on this area of research. It is worth noting that the Nigerian public health system does not have an effective and sustainable hearing loss screening strategy for lateonset hearing loss in adults. Aim/Objective: This study evaluated the hearing threshold and pure tone audiometric pattern/s seen in participants with agerelated hearing loss (ARHL) in Gwagwalada Area Council of the Federal capital territoryAbuja. Subjects and Methods: The study was a prospective communitybased crosssectional study, and a multistage sampling technique was adopted for this study, conducted at Gwagwalada, Abuja. Individuals from 55 years and above were recruited into the study after signing an informed consent. After a thorough and detailed clinical assessment, tympanometry and diagnostic puretone audiometry were carried out in all the participants. Result: One hundred and fourteen participants were recruited into the study, out of which fourteen were excluded from the analysis on account of various exclusion criteria. The age range of the participants was 55 to 79 years, with a mean age of 65.8 ± 5.6 years.Twentyfive (25.0%) participants had normal hearing threshold, while seventyfive (75.0%) participants had sensorineural hearing loss (SNHL). Conclusion: The study showed that the prevalence of ARHL from age 55 years and above at Gwagwalada Area Council, of FCT, Abuja was 75.0%.


Assuntos
Audiometria de Tons Puros/métodos , Perda Auditiva Neurossensorial/diagnóstico , Perda Auditiva/diagnóstico , Qualidade de Vida/psicologia , Testes de Impedância Acústica , Adolescente , Adulto , Idoso , Limiar Auditivo , Estudos Transversais , Feminino , Perda Auditiva/epidemiologia , Perda Auditiva/etiologia , Perda Auditiva Neurossensorial/epidemiologia , Perda Auditiva Neurossensorial/etiologia , Humanos , Masculino , Pessoa de Meia-Idade , Nigéria/epidemiologia , Prevalência , Estudos Prospectivos , Adulto Jovem
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