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1.
PLoS One ; 15(4): e0231632, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32324766

RESUMO

INTRODUCTION: From an epidemiological point of view, the increase of pure-tone hearing thresholds as one aspect of biological ageing is moderated by societal factors. Since health policies refer to empirical findings, it is reasonable to replicate population-based hearing surveys and to compare estimates for different birth cohorts from the same regions or, conversely, for the same birth cohorts from different regions. METHODS: We pooled data from two independent cross-sectional German studies conducted between 2008 and 2012 and including 3105 adults. The increase of thresholds, the prevalence and risk of hearing impairment (HI) by age and gender were compared to results reported for European and US-American studies that were carried out at about the same time. Since these studies differed with regard to the age limits, the statistical approaches and, importantly, their definitions of HI, data adjustments were performed to enable the comparison. RESULTS: Overall, 15.5% of the participants in the German studies showed a pure-tone average at 0.5, 1, 2, and 4 kHz in the better ear (PTA) greater than 25 dB HL and 8.6% had a PTA of at least 35 dB HL. Based on one-to-one comparisons, the German estimates demonstrated a good agreement to a large Dutch study and with some reservations to a Swedish study, but considerable differences to US-American results. Comprehensive comparisons of the within-study gender differences showed that age-related HI was less and the gender gap was markedly smaller in Europe compared to the US due to the lower HI in males found in the European studies. CONCLUSION: Discrepancies in measurement procedures, conditions, and equipment that complicate the comparison of absolute HI estimates across studies play no or only a marginal role when comparing relative estimates. Hence, the gender gap differences reviewed in this analysis possibly stem from societal conditions that distinguish societies commonly labeled modern industrialized western countries.


Assuntos
Perda Auditiva/epidemiologia , Caracteres Sexuais , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Audiometria de Tons Puros , Limiar Auditivo , Feminino , Alemanha/epidemiologia , Auxiliares de Audição , Perda Auditiva/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Fatores de Risco , Estados Unidos/epidemiologia , Adulto Jovem
2.
Adv Exp Med Biol ; 1218: 129-157, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32060875

RESUMO

Notch signalling is a major regulator of cell fate decisions and tissue patterning in metazoans. It is best known for its role in lateral inhibition, whereby Notch mediates competitive interactions between cells to limit adoption of a given developmental fate. However, it can also function by lateral induction, a cooperative mode of action that was originally described during the patterning of the Drosophila wing disc and creates boundaries or domains of cells of the same character. In this chapter, we introduce these two signalling modes and explain how they contribute to distinct aspects of the development and regeneration of the vertebrate inner ear, the organ responsible for the perception of sound and head movements. We discuss some of the factors that could influence the context-specific outcomes of Notch signalling in the inner ear and the ongoing efforts to target this pathway for the treatment of hearing loss and vestibular dysfunction.


Assuntos
Diferenciação Celular , Orelha Interna/embriologia , Orelha Interna/fisiologia , Receptores Notch/metabolismo , Regeneração , Transdução de Sinais , Animais , Orelha Interna/citologia , Orelha Interna/metabolismo , Perda Auditiva/metabolismo , Perda Auditiva/fisiopatologia , Humanos
3.
PLoS One ; 15(1): e0227978, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31961907

RESUMO

AIM: Occupational exposure to styrene has been shown to be associated with an increased probability of developing hearing loss. However, the sites of lesions in the auditory system in humans remain unknown. The aim of this study was to investigate the possible adverse effects of styrene exposure on the cochlea of human subjects. DESIGN: The hearing function of 98 styrene-exposed male workers from the glass fibre-reinforced plastics industry (mean concentration of 55 mg/m3) was evaluated bilaterally using pure-tone audiometry (1000-16000 Hz), distortion product otoacoustic emissions (DPOAEs), and auditory brainstem response (ABR). The results were compared to a group of 111 male workers exposed to noise (above 85 dBA) and 70 male white-collar workers exposed to neither noise nor solvents. Age and noise exposure levels were accounted for as confounding variables in all statistical models. RESULTS: Styrene exposure was significantly associated with poorer pure-tone thresholds (1-8 kHz), lower DPOAE amplitudes (5-6 kHz), and shorter wave V latencies in both ears compared to control-group subjects. Similar results were found among noise-exposed subjects. A further analysis with wave V latency showed that styrene-exposed subjects showed significantly shorter latencies than expected according to normative data. These results suggest that occupational exposure to styrene at moderate concentrations is associated with cochlear dysfunction, at least at high frequencies. DPOAEs may be considered a valuable diagnostic tool in hearing conservation programs in workers exposed to styrene.


Assuntos
Cóclea/fisiopatologia , Perda Auditiva , Exposição Ocupacional/efeitos adversos , Emissões Otoacústicas Espontâneas , Estireno/toxicidade , Adulto , Limiar Auditivo , Perda Auditiva/diagnóstico , Perda Auditiva/fisiopatologia , Perda Auditiva/prevenção & controle , Humanos , Masculino , Pessoa de Meia-Idade , Ruído/efeitos adversos , Adulto Jovem
4.
Dan Med J ; 67(1)2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31908252

RESUMO

INTRODUCTION: School-aged children with hearing impairment (HI) listen and learn in noisy environments. On-going monitoring of speech understanding in noise is essential to adjust clinical interventions accordingly. METHODS: The aim of this study was to assess Dantale II in a paediatric population. The secondary aims were identification of differences and similarities between groups of children with HI and normal hearing and between different hearing technologies; investigation of possible associations between Dantale II and verbal working memory. This was a longitudinal, prospective study comparing groups of children (n = 70) using the Dantale II with five-word sentences and verbal working memory with the Clinical Evaluation of Language Functioning-4. RESULTS: Dantale II seems clinically feasible from the age of six years. Children with NH outperformed children with HI both on completion of the tests and dB signal-to-noise ratio (SNR) scores. Children with hearing aids outperformed children with cochlear implants on dB SNR scores. A significant and moderately strong association between speech understanding in noise and verbal working memory was identified. CONCLUSIONS: Our study produced knowledge about a new generation of children with HI, who showed potentials not previously described. Future research on cognitive development of paediatric populations with HI is essential, as knowledge from adult populations cannot be transferred directly to paediatric populations. FUNDING: The project received funding from the Innovation Foundation, the Oticon Foundation, Decibel and The Capital Region of Denmark. TRIAL REGISTRATION: not relevant.


Assuntos
Audiometria da Fala/métodos , Testes com Listas de Dissílabos/métodos , Perda Auditiva/psicologia , Percepção da Fala , Criança , Linguagem Infantil , Pré-Escolar , Dinamarca , Feminino , Perda Auditiva/fisiopatologia , Humanos , Estudos Longitudinais , Masculino , Estudos Prospectivos , Razão Sinal-Ruído
5.
Braz J Otorhinolaryngol ; 86(1): 14-22, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-30337103

RESUMO

INTRODUCTION: Tinnitus is present in a large part of chronic health complaints, and it is considered a public health problem injurious to the individual's quality of life. Considering the increase of the world population associated with an increase of life expectancy, tinnitus remains a cause for medical concern, since during aging the occurrence of auditory impairments due to the deterioration of the peripheral auditory structures and central impairs the quality of life. OBJECTIVE: The aim of the present study was to analyze the applicability of real ear measurements for audiological intervention of tinnitus through specific evaluation, selection, verification and validation of the hearing aids combined with the sound generator. METHODS: Forty individuals of both genders with hearing loss and tinnitus complaints were deemed eligible to compose the sample. They were enrolled according to clinical symptoms and submitted to the following procedures: anamnesis and previous complaint history, high frequency audiometry, immittanciometry and acuphenometry with the research of psychoacoustic thresholds of pitch, loudness and minimum masking threshold, sound generator, in addition to the application of the Tinnitus Handicap Inventory and Visual Analog Scale tools. The entire sample was adapted with Siemens hearing aids and a sound generator, participated in a counseling session with support of digital material and evaluated in two situations: Initial Assessment (before the hearing aids and sound generator adaptation) and Final Assessment (6 months, after adaptation). The statistical analyzes were descriptive and inferential, adopted a significance level of 5% and the T-Paired Test and the Spearman Correlation test were performed. RESULTS: The results showed that there was a benefit with the use of hearing aids combined with a sound generator from the statistically significant values and strong correlations between the sound generator verification data regarding acuphenometry and the nuisance/severity questionnaires. Regarding the verification of the sound generator, it is important to highlight that the entire sample selected the effective acoustic stimulation based on the comfort levels, which was proved in the present study to be a sufficient intensity for positive prognosis, whereas the users' noises were found below the psychoacoustic thresholds of acuphenometry. CONCLUSION: The present study concluded that the audiological intervention with any level of sound stimulus is enough to obtain a positive prognosis in the medium term. Data that specifies that the verification of sound generator was effective at the real ear measurements are important in the evaluation and intervention of the complaint. In addition, it points out that the greater the tinnitus perception, the greater its severity, and the greater the nuisance, the higher the psychoacoustics thresholds of frequency and the minimum threshold of masking.


Assuntos
Estimulação Acústica/métodos , Idoso/fisiologia , Audição/fisiologia , Zumbido/fisiopatologia , Audiometria , Percepção Auditiva , Transtornos da Percepção Auditiva/fisiopatologia , Transtornos da Percepção Auditiva/reabilitação , Feminino , Auxiliares de Audição , Perda Auditiva/fisiopatologia , Perda Auditiva/reabilitação , Humanos , Masculino , Pessoa de Meia-Idade , Índice de Gravidade de Doença , Som , Zumbido/reabilitação
6.
Otolaryngol Head Neck Surg ; 162(2): 211-214, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31842677

RESUMO

Vestibular schwannomas (VSs) were proposed to arise from the glial-Schwann cell junction within the internal auditory canal (IAC). However, otopathology studies indicate that VS may arise anywhere along the course of the vestibular nerve. Recent studies suggested that the majority of tumors are located centrally within the IAC with an equal distribution near the porus acusticus and the fundus. However, these studies analyzed tumors of all sizes, obscuring their precise origin. Herein, we aim to quantify the position of small intracanalicular tumors (<5 mm), assessing hearing outcomes and growth patterns in relation to tumor position. Of the 38 small intracanalicular tumors analyzed, 61% originated closest to the fundus, 34% at the midpoint, and only 5% closest to the porus acusticus. Tumors were observed with serial magnetic resonance imaging for 3.37 ± 2.65 years (mean ± SD) without intervention. Our findings indicate a lateral predominance of small VS within the IAC, an independence between tumor location and hearing outcomes, and further support the slow natural progression of VS.


Assuntos
Perda Auditiva/diagnóstico , Audição/fisiologia , Imagem por Ressonância Magnética/métodos , Neuroma Acústico/diagnóstico , Nervo Vestibular/patologia , Idoso , Audiometria de Tons Puros , Feminino , Perda Auditiva/etiologia , Perda Auditiva/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Neuroma Acústico/complicações , Neuroma Acústico/fisiopatologia , Estudos Retrospectivos , Nervo Vestibular/fisiopatologia
7.
Am J Audiol ; 28(4): 1006-1014, 2019 Dec 16.
Artigo em Inglês | MEDLINE | ID: mdl-31825642

RESUMO

Purpose The purpose of this study was to investigate associations between performance on a clinical speech-in-noise measure with a comprehensive neurocognitive battery of tests. Method A group of older adults (N = 250, M age = 77 years, age range: 67.3-89.1 years) enrolled in the Atherosclerosis Risk in Communities Neurocognitive Study took part in the hearing pilot study (2013) that included testing for audiometric thresholds and speech-in-noise performance (Quick Speech-in-Noise Test; Killion, Niquette, Gudmundsen, Revit, & Banerjee, 2004). This research study analyzed the associations between domain-specific cognitive function and speech-in-noise performance after adjusting for hearing thresholds and other demographic and cardiovascular factors. Results Multivariable-adjusted associations were found between all cognitive domains and speech-in-noise performance in the full sample, but the observed associations varied when participants with varying levels of moderate to moderately severe hearing loss were excluded from the analysis. Conclusions The findings are discussed in terms considering the cognitive status of older adults in relation to their speech-in-noise performance during audiological evaluation and implications for aural rehabilitation.


Assuntos
Cognição , Ruído , Percepção da Fala , Idoso , Idoso de 80 Anos ou mais , Aterosclerose/fisiopatologia , Aterosclerose/psicologia , Limiar Auditivo , Estudos Transversais , Feminino , Perda Auditiva/fisiopatologia , Perda Auditiva/psicologia , Testes Auditivos , Humanos , Masculino , Testes de Estado Mental e Demência , Projetos Piloto
8.
Niger J Clin Pract ; 22(12): 1669-1674, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31793472

RESUMO

Objectives: The aim of this study was to develop a Turkish musical perception test that provide the opportunity to measure music performance of people with hearing loss. Subjects and Methods: In the study, the Music Perception Test (MPT), which was translated and adapted into Turkish, was applied randomly to 100 individuals aged between 18-40 years. The test was applied with computers and professional head phones to 20 individuals chosen as a pilot study. Data obtained after the pilot study were evaluated and the application to the other 80 participants were completed. In order to obtain validity and credibility data, 20 randomly chosen participants were retested. Results: The average total score of the MPT of the participants was 97.5 ± 12.2 (Min: 69, Max: 120). As the total score of the MPT has been examined, low value for ± 1SD was 85.3/top value was 109.7; low value for ± 2SS was 73.1/top value was 121.9; low value for ± 3SS was 60.9/top value was 134.1. In our study, the value of internal consistency of the Turkish MPT was 0.898. This value indicates that the test was reliable. In a similar manner, considering the correlation of test-retest parameters, both subtests and total score results showed the results were reliable. With the examination of the results there were no relation between the total scores of the MPT and age (r:0.176, p: 0.080) but the interest in music (r: 0.641, P < 0.001) and the frequency of listening to music (r:0.479, P < 0.001) had an important effect on the total scores of musical perception. The difference in the total scores of the MPT between female and male participants were found to be statistically significant (p < 0.001). Conclusions: Results of this study show that the Turkish MPT is a valid and reliable musical perception test for the Turkish people who have normal hearing and hearing loss.


Assuntos
Perda Auditiva/fisiopatologia , Testes Auditivos/métodos , Música , Adolescente , Adulto , Percepção Auditiva , Feminino , Perda Auditiva/diagnóstico , Humanos , Masculino , Pessoa de Meia-Idade , Avaliação de Processos e Resultados em Cuidados de Saúde , Projetos Piloto , Turquia , Adulto Jovem
9.
PLoS One ; 14(12): e0225071, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31809513

RESUMO

BACKGROUND: Fabry disease (FD) is a lysosomal storage disorder resulting in systemic accumulation of globotriaosylceramide resulting in multi-organ dysfunction e.g. cerebral, cardiac, renal and audiologic complications. The audiologic involvement in FD has often been neglected; while not a lethal aspect of the disease, hearing loss can have a significantly negative impact on quality of life. OBJECTIVES: To investigate baseline hearing status of the Danish Fabry cohort prior to treatment, compared to sex- and age-expected hearing levels and correlating hearing to renal and cerebral findings. MATERIAL AND METHODS: Retrospective study of baseline hearing status of the Danish Fabry cohort (n = 83, 9-72 years). Air conduction and speech discrimination scores were assessed at 6 frequencies between 0.25-8 kHz bilaterally. Data were collected between 2001-2014 and compiled in STATA using multilinear mixed modelling for statistical evaluation. RESULTS: Hearing thresholds at all frequencies deviated from the expected thresholds of an otologically normal cohort (p<0.001) and ranged 0.5 to 1.5 standard deviations below expected values. In total 29 males and 54 females were included. Hearing loss was more pronounced in the higher frequencies. There was a trend of association between hearing loss and measured glomerular filtration rate (mGFR) (p = 0.084). No association was present between hearing loss and albuminuria (p = 0.90), Fabry related cerebral abnormalities (p = 0.84) and cardiac left ventricular mass index, (LVMi) (p = 0.67) independent of sex. Hearing thresholds were poorer for men compared to women (p = 0.001). Sex differences were present at 0.25, 4 and 8 kHz. CONCLUSION: Our findings demonstrated significant hearing loss in Danish FD patients before treatment initiation, being more profound than in otologically healthy individuals at all frequencies. Additionally, we observed no association between hearing loss and LVMi, albuminuria or FD cerebral abnormalities, with a trend of association to mGFR. SYNOPSIS: Patients with Fabrys disease have hearing loss of all frequencies and most prominently at high frequencies (4-8 kHz), with no association between the hearing loss and cerebral abnormalities, and cardiac mass but with a trend of association to measured glomerular filtration rate.


Assuntos
Limiar Auditivo/fisiologia , Doença de Fabry/complicações , Perda Auditiva/etiologia , Adolescente , Adulto , Idoso , Audiometria de Tons Puros , Criança , Estudos de Coortes , Estudos Transversais , Dinamarca , Doença de Fabry/fisiopatologia , Feminino , Perda Auditiva/fisiopatologia , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Adulto Jovem
10.
J Int Adv Otol ; 15(3): 368-372, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31846913

RESUMO

OBJECTIVES: Differential sensitivity of intensity is known to be important for the perception of the relative distance of sounds in the environment, emotions of speakers, and localize sounds. However, a few features in listening devices, such as cochlear implants, used by individuals with hearing loss alter the output intensity heard by them. This makes soft sounds loud and loud sounds soft. Hence, the aim of the present study was to compare the intensity discrimination of children using cochlear implants with that of typically developing children. MATERIALS AND METHODS: Intensity discrimination of 30 children (15 using cochlear implants and 15 typically developing children) was obtained for three warble tones (500 Hz, 1000 Hz, and 4000 Hz) and three vowels (/a/, /i/, and /u/). The responses of the two participant groups, obtained using a 3-alternative forced-choice technique, were compared. RESULTS: Children using cochlear implants performed significantly poorer than typically developing children for the 4000 Hz warble tone and for the vowels /a/ and /u/. However, there was no significant difference for the remaining stimuli. CONCLUSION: The study indicated that the intensity discrimination threshold varies as a function of the frequency of the signals in children using cochlear implants. Intensity discrimination for high-frequency tones was significantly poorer for typically developing children, but not for low-frequency tones. In contrast, children using cochlear implants performed similarly to typically developing children for the high-frequency vowel but not for the mid- and low-frequency vowel.


Assuntos
Implante Coclear , Perda Auditiva/fisiopatologia , Audição , Localização de Som , Percepção da Fala , Adolescente , Criança , Desenvolvimento Infantil , Implantes Cocleares , Feminino , Perda Auditiva/cirurgia , Humanos , Masculino , Período Pós-Operatório
11.
BMJ Case Rep ; 12(11)2019 Nov 04.
Artigo em Inglês | MEDLINE | ID: mdl-31690691

RESUMO

Acoustic neuroma (AN) usually manifests with asymmetric hearing loss, tinnitus, dizziness and sense of disequilibrium. About 10% of patients complain of atypical symptoms, which include facial numbness or pain and sudden onset of hearing loss. Patients with atypical symptoms also tend to have larger tumours due to the delay in investigation. We report a particularly interesting case of a patient presented to us with numbness over her right hemifacial region after a dental procedure without significant acoustic and vestibular symptoms. Physical examination and pure tone audiometry revealed no significant findings but further imaging revealed a cerebellopontine angle mass. The changing trends with easier access to further imaging indicate that the presentation of patients with AN are also changing. Atypical symptoms which are persistent should raise clinical suspicion of this pathology among clinicians.


Assuntos
Neoplasias Cerebelares/patologia , Ângulo Cerebelopontino/patologia , Dor Facial/fisiopatologia , Perda Auditiva/fisiopatologia , Neuroma Acústico/patologia , Audiometria de Tons Puros , Neoplasias Cerebelares/complicações , Neoplasias Cerebelares/cirurgia , Dor Facial/etiologia , Feminino , Perda Auditiva/etiologia , Humanos , Pessoa de Meia-Idade , Neuroma Acústico/complicações , Neuroma Acústico/cirurgia , Período Pós-Operatório , Resultado do Tratamento
12.
Proc Natl Acad Sci U S A ; 116(47): 23753-23759, 2019 11 19.
Artigo em Inglês | MEDLINE | ID: mdl-31685611

RESUMO

Young healthy adults can hear tones up to at least 20 kHz. However, clinical audiometry, by which hearing loss is diagnosed, is limited at high frequencies to 8 kHz. Evidence suggests there is salient information at extended high frequencies (EHFs; 8 to 20 kHz) that may influence speech intelligibility, but whether that information is used in challenging listening conditions remains unknown. Difficulty understanding speech in noisy environments is the most common concern people have about their hearing and usually the first sign of age-related hearing loss. Digits-in-noise (DIN), a widely used test of speech-in-noise perception, can be sensitized for detection of high-frequency hearing loss by low-pass filtering the broadband masking noise. Here, we used standard and EHF audiometry, self-report, and successively higher cutoff frequency filters (2 to 8 kHz) in a DIN test to investigate contributions of higher-frequency hearing to speech-in-noise perception. Three surprising results were found. First, 74 of 116 "normally hearing," mostly younger adults had some hearing loss at frequencies above 8 kHz. Early EHF hearing loss may thus be an easily measured, preventive warning to protect hearing. Second, EHF hearing loss correlated with self-reported difficulty hearing in noise. Finally, even with the broadest filtered noise (≤8 kHz), DIN hearing thresholds were significantly better (P < 0.0001) than those using broadband noise. Sound energy above 8 kHz thus contributes to speech perception in noise. People with "normal hearing" frequently report difficulty hearing in challenging environments. Our results suggest that one contribution to this difficulty is EHF hearing loss.


Assuntos
Audição/fisiologia , Ruído , Percepção da Fala , Adulto , Feminino , Perda Auditiva/fisiopatologia , Humanos , Masculino , Adulto Jovem
13.
Am J Audiol ; 28(4): 895-907, 2019 Dec 16.
Artigo em Inglês | MEDLINE | ID: mdl-31747523

RESUMO

Purpose Brainstem auditory evoked response (BAER) testing is often performed under general anesthesia for children unable to complete behavioral audiologic evaluation. Alternatively, acupuncture treatment may be considered appropriate for BAER. Reports of acupuncture treatment in pediatric patients are scarce but are needed to demonstrate effectiveness. This study had 2 main objectives: (a) to examine the feasibility and effectiveness of acupuncture to achieve sleep to perform diagnostic BAER testing in medically complex (Cohort I) and nonmedically complex (Cohort II) children and (b) to assess acceptability to parents and audiologists of acupuncture as an alternative to anesthesia for BAER testing. Method A prospective feasibility study at Seattle Children's Hospital Outpatient Audiology Clinic from August 2015 through December 2018 was performed. A total of 31 pediatric patients were included. The median age for Cohort I was 29 months (interquartile range: 19-37 months), and the median age for Cohort II was 25.5 months (interquartile range: 16-32 months). Variables included number of BAER thresholds obtained, sleep indicators, and acceptability. The cost of BAER with acupuncture and the cost of BAER under anesthesia were compared. Results Acupuncture treatment effectively contributed to an adequate sleep state to obtain BAER results for most patients in both cohorts. Across cohorts, most patients (81%) fell asleep after acupuncture treatment. Complete test results were obtained in 48% of patients. Audiologists and parents reported high satisfaction rates with this procedure (87%). There were no adverse safety effects. Acupuncture treatment was less costly than anesthesia for BAER testing. Conclusions Acupuncture to induce sleep for BAER testing is effective, safe, and cost-efficient in small samples of medically and nonmedically complex pediatric patients. This procedure allowed earlier detection of hearing status and avoided potential adverse effects of anesthesia. Audiologists and parents reported that acupuncture treatment was an acceptable alternative to anesthesia for the BAER procedure.


Assuntos
Analgesia por Acupuntura/métodos , Potenciais Evocados Auditivos do Tronco Encefálico , Sono , Pontos de Acupuntura , Pré-Escolar , Potenciais Evocados Auditivos do Tronco Encefálico/fisiologia , Estudos de Viabilidade , Perda Auditiva/diagnóstico , Perda Auditiva/fisiopatologia , Humanos , Lactente , Sono/fisiologia
14.
Am J Audiol ; 28(4): 843-856, 2019 Dec 16.
Artigo em Inglês | MEDLINE | ID: mdl-31647880

RESUMO

Purpose The aim of this study was to quantify the portion of variance in several measures suggested to be indicative of peripheral noise-induced cochlear synaptopathy and hidden hearing disorder that can be attributed to individual cognitive capacity. Method Regression and relative importance analysis was used to model several behavioral and physiological measures of hearing in 32 adults ranging in age from 20 to 74 years. Predictors for the model were hearing sensitivity and performance on a number of cognitive tasks. Results There was a significant influence of cognitive capacity on several measures of cochlear synaptopathy and hidden hearing disorder. These measures include frequency modulation detection threshold, time-compressed word recognition in quiet and reverberation, and the strength of the frequency-following response of the speech-evoked auditory brainstem response. Conclusions Measures of hearing that involve temporal processing are significantly influenced by cognitive abilities, specifically, short-term and working memory capacity, executive function, and attention. Research using measures of temporal processing to diagnose peripheral disorders, such as noise-induced synaptopathy, need to consider cognitive influence even in a young, healthy population.


Assuntos
Cóclea/lesões , Cognição/fisiologia , Perda Auditiva Provocada por Ruído/fisiopatologia , Perda Auditiva/fisiopatologia , Testes de Impedância Acústica , Adulto , Idoso , Audiometria , Limiar Auditivo , Cóclea/fisiopatologia , Feminino , Perda Auditiva/psicologia , Perda Auditiva Provocada por Ruído/psicologia , Perda Auditiva Neurossensorial/fisiopatologia , Perda Auditiva Neurossensorial/psicologia , Humanos , Masculino , Pessoa de Meia-Idade , Testes Neuropsicológicos , Percepção da Fala , Adulto Jovem
15.
Audiol Neurootol ; 24(5): 253-257, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31661686

RESUMO

BACKGROUND: The most common complaint of patients affected by chemotherapy-induced hearing loss is difficulty understanding speech in noisy environments despite the use of hearing aids. Cochlear dead regions, those areas with damaged or absent inner hair cells and dendrites, may account for this type of hearing loss. However, it is unknown whether this condition is associated with cisplatin agents. OBJECTIVE: The aim of this study was to determine whether cisplatin is associated with hearing loss and cochlear dead regions. METHODS: This prospective cross-sectional study was conducted in patients participating in routine audiological monitoring during and after chemotherapy treatment. Adults undergoing audiological evaluation who had completed chemotherapy treatment were invited to participate. Patients were divided into 3 groups according to pure tone thresholds. Group 1 patients had thresholds over 70 dB (HL) at 2,000 Hz and higher frequencies. Group 2 patients had thresholds below 70 dB (HL) up to 2,000 Hz. Patients in the control group had normal thresholds at all frequencies. The threshold equalizing noise test (TEN[HL]) was used to identify cochlear dead regions by repeating thresholds in the presence of TEN noise played from a compact disc. The presence of cochlear dead regions was established when the masked threshold was 10 dB or greater above the TEN level and 10 dB or greater above the absolute threshold at any frequency. RESULTS: Twelve patients were included in study group 1, 10 patients in study group 2, and 7 patients in the control group. Cochlear dead regions were present in all patients with hearing loss and in none of the control group. For groups 1 and 2, mean differences between absolute and masked thresholds were 21 and 16 dB at 500 Hz; 22 and 15 dB at 1,000 Hz; 31 and 17 dB at 2,000 Hz; 32 and 20 dB at 3,000 Hz; and 31 and 21 dB at 4,000 Hz, respectively. Nevertheless, analysis of variance testing with Bonferroni analysis showed a difference between groups 1 and 2 only at 2,000, 3,000, and 4,000 Hz. CONCLUSION: We found unresponsive or dead cochlear regions in patients who had undergone cisplatin chemotherapy even among patients with mild to moderate hearing loss.


Assuntos
Limiar Auditivo/fisiologia , Cisplatino/efeitos adversos , Cóclea/fisiopatologia , Perda Auditiva/fisiopatologia , Ototoxicidade/fisiopatologia , Adolescente , Adulto , Idoso , Audiometria , Limiar Auditivo/efeitos dos fármacos , Cóclea/efeitos dos fármacos , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Adulto Jovem
16.
Acta otorrinolaringol. esp ; 70(5): 251-257, sept.-oct. 2019. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-186367

RESUMO

Introducción y objetivos: La inadecuada retroalimentación auditiva en los niños con hipoacusia prelocutiva altera la articulación de consonantes y vocales. El propósito de esta investigación es comparar la producción de vocales en niños hipoacúsicos hispanohablantes con implante coclear o adaptación audioprotésica con niños normooyentes por medio del análisis acústico de las frecuencias formánticas y el espacio vocal. Método: Un total de 56 niños con hipoacusia prelocutiva (25 con implante coclear y 31 con audífonos) y 47 niños normooyentes participaron en el estudio. Los 2 primeros formantes (F1 y F2) de las 5 vocales del idioma español se midieron utilizando el programa Praat. Para analizar las diferencias entre los 3 grupos se aplicó el método ANOVA de análisis de la varianza y el test de Scheffé. También se calculó el área del espacio vocal. Resultados: El valor medio del F1 en todas las vocales no mostró diferencias significativas en los 3 grupos de niños. Para las vocales /i/, /o/ y /u/ el valor medio del F2 fue significativamente diferente entre los 2 grupos de niños hipoacúsicos y el grupo de niños normooyentes. Conclusión: Ambos grupos de niños con hipoacusia prelocutiva tienden a presentar sutiles desviaciones en la articulación de las vocales que pueden ser analizadas mediante un programa de análisis acústico


Introduction and objectives: Inadequate auditory feedback in prelingually deaf children alters the articulation of consonants and vowels. The purpose of this investigation was to compare vowel production in Spanish-speaking deaf children with cochlear implantation, and with hearing-aids with normal-hearing children by means of acoustic analysis of formant frequencies and vowel space. Methods: A total of 56 prelingually deaf children (25 with cochlear implants and 31 wearing hearing-aids) and 47 normal-hearing children participated. The first 2 formants (F1 and F2) of the five Spanish vowels were measured using Praat software. One-way analysis of variance (ANOVA) and post hoc Scheffé test were applied to analyze the differences between the 3 groups. The surface area of the vowel space was also calculated. Results: The mean value of F1 in all vowels was not significantly different between the 3 groups. For vowels /i/, /o/ and /u/, the mean value of F2 was significantly different between the 2 groups of deaf children and their normal-hearing peers. Conclusion: Both prelingually hearing-impaired groups tended toward subtle deviations in the articulation of vowels that could be analyzed using an objective acoustic analysis programme


Assuntos
Humanos , Masculino , Feminino , Pré-Escolar , Criança , Transtornos da Articulação/etiologia , Implantes Cocleares , Auxiliares de Audição , Perda Auditiva/complicações , Pessoas com Deficiência Auditiva , Fonética , Transtornos da Articulação/fisiopatologia , Retroalimentação Sensorial , Perda Auditiva/fisiopatologia , Perda Auditiva/reabilitação , Acústica da Fala , Medida da Produção da Fala , Qualidade da Voz
17.
Int J Pediatr Otorhinolaryngol ; 127: 109678, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31536854

RESUMO

BACKGROUND: Auditory performance outcome of children with hearing impairment has been widely studied, and the related factors of the performance have been explored among different age groups for English speaking hearing impaired children. OBJECTIVES: The objective of this study was to construct Arabic questionnaires for the evaluation of the auditory abilities of hearing impaired Egyptian Arabic-speaking children. METHODS: Three Arabic questionnaires targeting the auditory abilities were constructed by selecting items from different English-based questionnaires and translating them into Arabic and adapted to Egyptian culture. The questionnaires were administered to 210 Arabic-speaking Egyptian children in the age range 1-12 years who were divided into three age groups. They included 90 hearing impaired children fitted with hearing aids and 30 hearing impaired children with a cochlear implant and 90 children with normal hearing (as a control group). Participants' responses were statistically analyzed to assess the validity and reliability of the questionnaires and to compare hearing impaired children with normal hearing children. RESULTS: There were non-significant differences between cochlear implanted children and children with hearing aids regarding auditory abilities performances. Language age and aided pure tone audiometry were considered the best predictors of auditory abilities of hearing impaired Egyptian children. CONCLUSION: The constructed Arabic questionnaires proved to be reliable and valid functional assessment tools that provide information about auditory behaviors of hearing impaired Egyptian children in everyday life and would complement other objective test results in evaluating and monitoring the performance of these children.


Assuntos
Perda Auditiva/fisiopatologia , Audição , Inquéritos e Questionários , Audiometria de Tons Puros , Criança , Pré-Escolar , Implantes Cocleares , Egito , Feminino , Auxiliares de Audição , Perda Auditiva/reabilitação , Humanos , Lactente , Desenvolvimento da Linguagem , Masculino , Reprodutibilidade dos Testes , Traduções
18.
Nat Commun ; 10(1): 4150, 2019 09 12.
Artigo em Inglês | MEDLINE | ID: mdl-31515474

RESUMO

Cisplatin is one of the most widely used chemotherapeutic drugs for the treatment of cancer. Unfortunately, one of its major side effects is permanent hearing loss. Here, we show that glutathione transferase α4 (GSTA4), a member of the Phase II detoxifying enzyme superfamily, mediates reduction of cisplatin ototoxicity by removing 4-hydroxynonenal (4-HNE) in the inner ears of female mice. Under cisplatin treatment, loss of Gsta4 results in more profound hearing loss in female mice compared to male mice. Cisplatin stimulates GSTA4 activity in the inner ear of female wild-type, but not male wild-type mice. In female Gsta4-/- mice, cisplatin treatment results in increased levels of 4-HNE in cochlear neurons compared to male Gsta4-/- mice. In CBA/CaJ mice, ovariectomy decreases mRNA expression of Gsta4, and the levels of GSTA4 protein in the inner ears. Thus, our findings suggest that GSTA4-dependent detoxification may play a role in estrogen-mediated neuroprotection.


Assuntos
Cisplatino/efeitos adversos , Glutationa Transferase/metabolismo , Ototoxicidade/enzimologia , Animais , Limiar Auditivo/efeitos dos fármacos , Capilares/patologia , Cóclea/enzimologia , Cóclea/patologia , Cóclea/fisiopatologia , Cruzamentos Genéticos , Dano ao DNA/genética , Potenciais Evocados Auditivos do Tronco Encefálico/efeitos dos fármacos , Feminino , Regulação da Expressão Gênica/efeitos dos fármacos , Glutationa Transferase/deficiência , Perda Auditiva/complicações , Perda Auditiva/enzimologia , Perda Auditiva/fisiopatologia , Masculino , Camundongos Endogâmicos CBA , Ototoxicidade/complicações , Ototoxicidade/patologia , Ototoxicidade/fisiopatologia , Estresse Oxidativo/efeitos dos fármacos , RNA Mensageiro/genética , RNA Mensageiro/metabolismo , Gânglio Espiral da Cóclea/efeitos dos fármacos , Gânglio Espiral da Cóclea/patologia
19.
PLoS One ; 14(9): e0222711, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31536550

RESUMO

Cochlear implantation is a surgical procedure, which is performed on severely hearing-impaired patients. Impedance field telemetry is commonly used to determine the integrity of the cochlear implant device during and after surgery. At the Department of Otolaryngology, Cheng Hsin General Hospital (Taipei, Taiwan), the cochlear implant devices are switched on within 24 hours of their implantation. In the present study, the impedance changes of Advanced Bionics™ cochlear implant devices were compared with previous studies and other devices. The aim was to confirm previous hypotheses and to explore other potential associated factors that could influence impedance following cochlear implantation. The current study included 12 patients who underwent cochlear implantation at Cheng Hsin General Hospital with Advanced Bionics cochlear implant devices. The cochlear devices were all switched on within 24 hours of their implantation. The impedance was measured and compared across all contact channels of the electrode, both intra-operatively and post-operatively. The intra-operative impedance was compared with the switch-on impedance (within 24 hours of the cochlear implantation); the impedance was notably increased for all contact channels at switch-on. Of the 16 channels examined, 4 channels had a significant increase in impedance between the intra-operative measurement and the switch-on measurement. To the best of our knowledge, the impedance of a cochlear implant device can be affected by the diameter of the electrode, the position of the electrode arrays in the scala tympani, sheath formation and fibrosis surrounding the electrode after implantation and electrical stimulation during or after surgery. When the results of the current study were compared with previous studies, it was found that the impedance changes were opposite to that of Cochlear™ implant devices. This may be explained by the position of the electrode arrays, sheath formation, the blow-out effect and differences in electrical stimulation.


Assuntos
Cóclea/fisiopatologia , Implante Coclear/instrumentação , Implantes Cocleares , Impedância Elétrica , Eletrodos Implantados , Adulto , Biônica/instrumentação , Biônica/métodos , Implante Coclear/métodos , Estimulação Elétrica , Feminino , Perda Auditiva/fisiopatologia , Perda Auditiva/terapia , Humanos , Masculino , Taiwan , Fatores de Tempo
20.
Int J Mol Sci ; 20(19)2019 Sep 20.
Artigo em Inglês | MEDLINE | ID: mdl-31547176

RESUMO

Noise-induced hearing loss (NIHL) relates closely to auditory cortex (AC) injury, so countermeasures aiming at the AC recovery would be of benefit. In this work, the effect of hyperbaric oxygen treatment on NIHL was elucidated, which was imposed on mice before (HBOP), during (HBOD) or after (HBOA) noise exposure. Morphology of neurons was assayed by hematoxylin-eosin or Nissl staining. Ceramide (Cer) level was measured through immunohistochemistry analysis. Apoptotic neurons were counted using transferase-mediated dUTP nick end labeling (TUNEL) staining. We demonstrated that the intense, broad band noise raised the threshold of auditory brainstem response, evoked neuronal degeneration or apoptosis and triggered the Cer accumulation in AC, all of which were restored significantly by HBOP, but not HBOD or HBOA. Cer over-generation reversed the advantages of HBOP significantly, while its curtailment recapitulated the effect. Next, noise exposure raised the superoxide or malondialdehyde (MDA) production which was blocked by HBOP or Cer repression. Oxidative control not only attenuated the hearing loss or neurodegeneration but, in turn, reduced the Cer formation significantly. In summary, mutual regulation between Cer and oxidative stress underlies the HBOP's curative effect on hearing loss and neuronal damage in noise-exposed mice.


Assuntos
Córtex Auditivo , Ceramidas/metabolismo , Perda Auditiva , Oxigenação Hiperbárica , Ruído/efeitos adversos , Animais , Córtex Auditivo/patologia , Córtex Auditivo/fisiopatologia , Perda Auditiva/metabolismo , Perda Auditiva/patologia , Perda Auditiva/fisiopatologia , Perda Auditiva/terapia , Masculino , Camundongos
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