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1.
Artigo em Inglês | MEDLINE | ID: mdl-34202699

RESUMO

This work provides a narrative review covering evidence-based recommendations for pericoronitis management (Part A) and a systematic review of antibiotic prescribing for pericoronitis from January 2000 to May 2021 (Part B). Part A presents the most recent, clinically significant, and evidence-based guidance for pericoronitis diagnosis and proper treatment recommending the local therapy over antibiotic prescribing, which should be reserved for severe conditions. The systematic review includes publications analyzing sets of patients treated for pericoronitis and questionnaires that identified dentists' therapeutic approaches to pericoronitis. Questionnaires among dentists revealed that almost 75% of them prescribed antibiotics for pericoronitis, and pericoronitis was among the top 4 in the frequency of antibiotic use within the surveyed diagnoses and situations. Studies involving patients showed that antibiotics were prescribed to more than half of the patients with pericoronitis, and pericoronitis was among the top 2 in the frequency of antibiotic use within the monitored diagnoses and situations. The most prescribed antibiotics for pericoronitis were amoxicillin and metronidazole. The systematic review results show abundant and unnecessary use of antibiotics for pericoronitis and are in strong contrast to evidence-based recommendations summarized in the narrative review. Adherence of dental professionals to the recommendations presented in this work can help rapidly reduce the duration of pericoronitis, prevent its complications, and reduce the use of antibiotics and thus reduce its impact on patients' quality of life, healthcare costs, and antimicrobial resistance development.


Assuntos
Antibacterianos , Pericoronite , Antibacterianos/efeitos adversos , Odontologia , Odontólogos , Humanos , Prescrição Inadequada , Pericoronite/tratamento farmacológico , Padrões de Prática Odontológica , Qualidade de Vida
2.
Biomed Res Int ; 2021: 6664434, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33728338

RESUMO

Background: Pericoronitis is a painful inflammatory condition commonly associated with third molar teeth. The purpose of this study was to investigate the relationship between oral hygiene and periodontal health status and the presence of pericoronitis in semi-impacted third molar teeth. Methods: A cross-sectional study was conducted, and 54 patients having at least one mandibular vertically semi-impacted third molar tooth with or without pericoronitis were consecutively enrolled. Subjects with pericoronitis and subjects with healthy third molars were selected according to symptoms in the gingiva overlying semi-impacted third molar teeth. Periodontal health status and oral hygiene were evaluated with the measures of plaque index (PI), gingival index (GI), and total number of sites with a probing depth (PD) ≥ 4 mm. The clinical data collected in this study was analyzed with Mann-Whitney U test using SPSS 20.0 package program. Results: The PI scores were found to be significantly higher in patients with pericoronitis (p < 0.05). Although the GI scores and PD scores were higher in patients with pericoronitis, the difference did not reach statistical significance when compared with those in healthy subjects (p > 0.05). Conclusion: The findings obtained in this study suggest that the amount of dental plaque was positively associated with third molar pericoronitis. Gingival and periodontal health conditions were similar between patients with and without pericoronitis. Improving oral hygiene and controlling dental plaque may help prevent third molar pericoronitis.


Assuntos
Dente Serotino , Higiene Bucal , Pericoronite , Dente Impactado/patologia , Adolescente , Adulto , Estudos Transversais , Feminino , Humanos , Masculino , Pericoronite/patologia , Pericoronite/prevenção & controle
3.
Dental press j. orthod. (Impr.) ; 26(1): e21ins1, 2021. graf
Artigo em Inglês | LILACS, BBO - Odontologia | ID: biblio-1154067

RESUMO

ABSTRACT Introduction: The third molars are forgotten because they are the last in the dental arch, they do not directly influence the smile and they appear only in adolescence, when they do. Objectives: 1) to provide the clinician with a "checklist" to assess and diagnose changes to be screened in the third molar region in new patients; 2) to reveal the importance of not discharging the patient submitted to any dental treatment without first analyzing the third molars region clinically and on imaging examinations, since many diseases are associated to them. Result: A list of 10 situations that cover all diagnostic possibilities involving the third molars is presented. Conclusion: Adopting this protocol is a matter of habit, since the need is fundamental. The next professional assisting your patient may ask: "Did he not request examinations for the third molars?".


RESUMO Introdução: Os terceiros molares são esquecidos por serem os últimos dentes na arcada dentária, por não influenciarem diretamente no sorriso e por aparecerem apenas na adolescência - quando aparecem. Objetivos: 1) Fornecer ao clínico um checklist de conferência e diagnóstico de alterações a serem checadas na região dos terceiros molares em novos pacientes; e 2) Destacar a importância de não dar alta ao paciente submetido a qualquer tratamento odontológico sem antes analisar, clínica e imagiologicamente, a região dos terceiros molares, pois muitas doenças estão a eles associadas. Resultado: Criou-se uma lista de 10 situações que englobam todas as possibilidades diagnósticas envolvendo os terceiros molares. Conclusão: Adotar esse protocolo é uma questão de hábito, pois a necessidade é imperiosa. O próximo profissional a atender o seu paciente vai perguntar: "Ele não solicitou exames para os terceiros molares?".


Assuntos
Humanos , Masculino , Adolescente , Mandíbula , Dente Serotino , Pericoronite , Reabsorção de Dente , Dente não Erupcionado , Cisto Dentígero , Dente Serotino/diagnóstico por imagem
4.
Ned Tijdschr Tandheelkd ; 127(7-08): 406-408, 2020.
Artigo em Holandês | MEDLINE | ID: mdl-32840495

RESUMO

A 24-year-old woman presented with trismus, which had left her unable to open her mouth beyond 1 centimetre. It proved to be a pericoronitis with lingual swelling in the region of tooth 38. The trismus disappeared after removal of the 38. After a week, however, a submandibular swelling occurred. From this, an orocutaneous neck fistula developed from which a hay stalk was removed. In retrospect, the hay stalk ended up under the operculum of tooth 38 after eating meat cooked in hay, the stalk next made its way to the neck.


Assuntos
Fístula , Pericoronite , Adulto , Feminino , Humanos , Trismo , Adulto Jovem
7.
Oral Maxillofac Surg ; 24(4): 447-453, 2020 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-32617697

RESUMO

PURPOSE: The teeth positioning may be an important associated factor for the pericoronitis' clinical signs. Our objective was to verify the association between lower third molar position according to the Pell and Gregory classification and clinical variables in patients with pericoronitis. METHODS: Cross-sectional analysis of panoramic radiographs and medical records of patients with pericoronitis. Primary outcomes: pain and oral health-related quality of life (OHRQoL); secondary outcomes: mouth opening, edema/erythema extension, visible plaque index, bleeding on probing index, periodontal pocket probing depth, and distal alveolar bone crest height of the adjacent second molar. RESULTS: The edema/erythema extension was higher in the IIA position compared with the IA position (p = 0.03). Regarding the OHRQoL, the OHIP-14 score was 21.0 (± 9.26, range from 4 to 44). The most scored domain was physical pain (5.24), followed by psychological discomfort (4.43). Third molars in IIA position are associated with worse OHRQoL than IB and IIB positions (p = 0.03). CONCLUSIONS: There was a higher extension of edema/erythema and worse OHRQoL when the third molar was in IIA position. Prophylactic removal of mandibular third molar in position IIA may avoid the onset of mucosal edema/erythema and prevent pericoronitis from promoting impairment of individuals' quality of life.


Assuntos
Pericoronite , Dente Impactado , Estudos Transversais , Humanos , Mandíbula/diagnóstico por imagem , Dente Serotino/diagnóstico por imagem , Qualidade de Vida , Dente Impactado/diagnóstico por imagem
8.
Photodiagnosis Photodyn Ther ; 31: 101830, 2020 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-32512248

RESUMO

AIM: We evaluated the efficacy of antimicrobial photodynamic therapy (A-PDT) in the reduction of pain intensity and performed cytokine profiling and measurement of microbiological parameters in patients with acute pericoronitis. METHODS: Sixty patients with age range 14-19 years were randomized into two groups: 'A-PDT group' which received additional A-PDT with conventional protocol, and 'conventional protocol group' (CPG) without A-PDT. Present pain intensity (PPI) were investigated using McGill Pain Questionnaire (MPQ) and Visual Analogue Scale (VAS). Gingival crevicular fluid were sampled to evaluate the levels of interleukin (IL)-6 and tumor necrosis factor-alpha (TNF-α) and quantified using enzyme-linked immunosorbent assay. Microbial plaque was collected to evaluate total counts of Porphyromonas gingivalis and Tannerella forsythia expressed as log colony forming unit (CFU)/mL. Level of pain intensity, cytokine profiling and microbial load were assessed at baseline (B0), and post treatment F7 (Day 7) and F14 (Day 14). RESULTS: A total of 59 patients (30 CPG and 29 A-PDT) completed the clinical trial. Present pain intensity scores statistically significantly reduced from B0 to F7 in both treatment groups (p < 0.05). For VAS, both groups showed statistically significant reduction in pain scores at F14 only when compared with baseline (p < 0.05). There was no inter-group significant difference at any time point for either pain scores (p > 0.05). Only TNF-α showed statistically significant reduction with A-PDT compared to CPG at both F7 and F14. CPG group showed significant reduction for only T. forsythia at both follow-up points. The microbial counts for P. gingivalis and T. forsythia significantly reduced in A-PDT groups compared to CPG group at both F7 and F14. CONCLUSION: The results of this study indicate that A-PDT may be a reliable treatment option in pericoronitis for the reduction of TNF-α and microbial load. However, A-PDT does not have any effect in the reduction of pain.


Assuntos
Pericoronite , Fotoquimioterapia , Adolescente , Adulto , Humanos , Dor/tratamento farmacológico , Fotoquimioterapia/métodos , Fármacos Fotossensibilizantes/uso terapêutico , Resultado do Tratamento , Adulto Jovem
9.
Br J Oral Maxillofac Surg ; 58(2): 179-184, 2020 02.
Artigo em Inglês | MEDLINE | ID: mdl-31866061

RESUMO

We have evaluated and compared the outcomes after conservatively treated and surgically managed third molars in patients with mild pericoronitis at the first, third, and sixth postoperative months, and we rated patients' quality of life (QoL) using the Oral Health Impact Profile-14 (OHIP-14) index. Of the 128 patients who were originally assessed as eligible we studied 100 patients who fulfilled the protocol, being diagnosed with mild pericoronitis that affected the third molar teeth and who were followed up for six months. Fifty were treated by the periodontal approach and 50 by extraction of third molars. Their oral health-related QoL was assessed using the OHIP-14 index on a personal assessment question form and then repeated at the first, third, and sixth months. The data were analysed using the Mann Whitney, Friedman's, and Wilcoxon's test, as appropriate. There was a significant difference between the total OHIP-14 scores at different time points (p<0.0001). In both groups the three postoperative total OHIP-14 scores were significantly lower than the baseline score, and we noted a further decrease in OHIP-14 scores in the surgical treatment group. Periodontal treatment of mandibular third molar teeth may effectively reduce (but does not eliminate) symptoms, whereas tooth extraction seems to be more effective at the long term.


Assuntos
Pericoronite , Dente Impactado , Humanos , Mandíbula , Dente Serotino , Qualidade de Vida , Extração Dentária
10.
J Appl Oral Sci ; 28: e20190266, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-31800877

RESUMO

OBJECTIVE: The microbial composition of pericoronitis (Pc) is still controversial; it is not yet clear if the microbial profile of these lesions is similar to the profile observed in periodontitis (Pd). Therefore, the aim of the present study was to describe the microbial profile of Pc lesions and compare it directly with that of subjects with Pd. METHODOLOGY: Subjects with Pc and Pd were selected, and subgingival biofilm samples were collected from (i) third molars with symptomatic Pc (Pc-T), (ii) contralateral third molars without Pc (Pc-C) and (iii) teeth with a probing depth >3 mm from subjects with Pd. Counts and proportions of 40 bacterial species were evaluated using a checkerboard DNA-DNA hybridization technique. RESULTS: Twenty-six patients with Pc and 18 with Pd were included in the study. In general, higher levels of microorganisms were observed in Pd. Only Actinomyces oris and Eubacterium nodatum were present in higher mean counts in the Pc-T group in comparison with the Pc-C and Pd-C groups (p<0.05). The microbiota associated with Pc-T was similar to that found in Pc-C. Sites with Pc lesions had lower proportions of red complex in comparison with the Pd sites. CONCLUSION: The microbiota of Pc is very diverse, but these lesions harbour lower levels of periodontal pathogens than Pd.


Assuntos
Bactérias/isolamento & purificação , Pericoronite/microbiologia , Periodontite/microbiologia , Análise por Ativação , Adulto , Idoso , Carga Bacteriana , Biofilmes , Estudos Transversais , Sondas de DNA , Feminino , Gengiva/microbiologia , Humanos , Masculino , Pessoa de Meia-Idade , Valores de Referência , Adulto Jovem
11.
J. appl. oral sci ; 28: e20190266, 2020. graf
Artigo em Inglês | LILACS, BBO - Odontologia | ID: biblio-1056586

RESUMO

Abstract Objective: The microbial composition of pericoronitis (Pc) is still controversial; it is not yet clear if the microbial profile of these lesions is similar to the profile observed in periodontitis (Pd). Therefore, the aim of the present study was to describe the microbial profile of Pc lesions and compare it directly with that of subjects with Pd. Methodology: Subjects with Pc and Pd were selected, and subgingival biofilm samples were collected from (i) third molars with symptomatic Pc (Pc-T), (ii) contralateral third molars without Pc (Pc-C) and (iii) teeth with a probing depth >3 mm from subjects with Pd. Counts and proportions of 40 bacterial species were evaluated using a checkerboard DNA-DNA hybridization technique. Results: Twenty-six patients with Pc and 18 with Pd were included in the study. In general, higher levels of microorganisms were observed in Pd. Only Actinomyces oris and Eubacterium nodatum were present in higher mean counts in the Pc-T group in comparison with the Pc-C and Pd-C groups (p<0.05). The microbiota associated with Pc-T was similar to that found in Pc-C. Sites with Pc lesions had lower proportions of red complex in comparison with the Pd sites. Conclusion: The microbiota of Pc is very diverse, but these lesions harbour lower levels of periodontal pathogens than Pd.


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Pericoronite/microbiologia , Periodontite/microbiologia , Bactérias/isolamento & purificação , Valores de Referência , Análise por Ativação , Sondas de DNA , Estudos Transversais , Biofilmes , Carga Bacteriana , Gengiva/microbiologia
12.
Artigo em Espanhol | MOSAICO - Saúde integrativa | ID: biblio-1252463

RESUMO

Fundamento: existen antecedentes del empleo efectivo de la ozonoterapia en el tratamiento de enfermedades bucales. Objetivo: evaluar la efectividad del Oleozón en el tratamiento de enfermedades bucales en pacientes mayores de 12 años de edad, que acudieron al Policlínico Universitario "Guillermo Tejas" en el período de septiembre 2015 a diciembre 2019. Métodos: se realizó una intervención terapéutica con ozonoterapia en los pacientes, institución y durante el periodo de tiempo ya declarados. Se consideraron las enfermedades: estomatitis subprótesis, pulpitis aguda transitoria, estomatitis aftosa recurrente, alveolitis, pericoronaritis, gingivitis crónica edematosa, caries dental en dentina profunda y conductos radiculares infectados. La muestra quedó conformada por 464 pacientes distribuidos de forma equitativa y, según diagnóstico de enfermedad bucal, en dos grupos: de estudio y de control. Se evaluaron al tercer, quinto y séptimo días de tratamiento. Resultados: según sexo, existió mayor presencia del sexo femenino, con 249 (53,7 %); de las enfermedades, la alveolitis predominó en 102 pacientes (21,9 %), seguido de la estomatitis subprótesis (80 pacientes, 17,2 %). Al tercer día, en el grupo de estudio evolucionaron favorablemente 97 pacientes (41,8 %), ya al séptimo día sumaban 209 (90,1 %). En el grupo control, al tercer día solo 61 pacientes (26,2 %) habían evolucionado favorablemente, llegando a 182 (78,4 %) al séptimo día del tratamiento. No se notificaron reacciones adversas, solo el olor y sabor desagradables. Conclusiones: la ozonoterapia resultó un tratamiento efectivo para las enfermedades bucales en los pacientes del estudio.


Background: there is a history of the effective use of ozone therapy in the treatment of oral diseases. Objective: to assess the effectiveness of oleozon in the treatment of oral diseases in patients older than 12 years of age who presented to the "Guillermo Tejas" University Polyclinic, from September 2015 to December 2019. Methods: a therapeutic intervention with ozone therapy was performed with the patients, institution and during the period of time herein declared. The following diseases were considered: subprosthesis stomatitis, transient acute pulpitis, recurrent aphthous stomatitis, alveolitis, pericoronitis, chronic edematous gingivitis, dental caries in deep dentin and infected root canals. The sample was made up of 464 patients fairly distributed, and according to the diagnosis of oral disease, in two groups, cases and controls. The third, fifth and seventh days of treatment were assessed. Results: according to sex, there was a greater presence of women with 249 (53,7 %); of the diseases, alveolitis predominated in 102 patients (21,9 %), followed by subprosthesis stomatitis (80 patients, 17,2 %). On the third day, 97 patients (41,8 %) progressed favorably in the case group, and on the seventh day they were 209 (90,1 %). In the control group, on the third day only 61 patients (26,2 %) had progressed favorably, reaching 182 (78,4 %) on the seventh day of treatment. No adverse reactions were reported, save for the unpleasant smell and taste. Conclusions: ozone therapy was an effective treatment for oral diseases in the studied patients.


Assuntos
Humanos , Masculino , Feminino , Ozônio/uso terapêutico , Doenças da Boca , Pericoronite , Estomatite , Terapias Complementares , Gengivite
13.
Med Sci Monit ; 25: 9200-9206, 2019 Dec 03.
Artigo em Inglês | MEDLINE | ID: mdl-31860632

RESUMO

BACKGROUND Pericoronitis is inflammation of the tissue surrounding a third molar, or wisdom tooth. This study aimed to evaluate the effects of oral and topical analgesic nonsteroidal anti-inflammatory drugs (NSAIDs) on oral health-related quality of life (OHQoL), in terms of oral health and lifestyle, in patients with symptomatic pericoronitis. MATERIAL AND METHODS The study included 60 patients who presented with pericoronitis and who did not undergo surgery within the following seven days. The patients were randomly assigned to three groups and were treated with oral diclofenac (N=20), oral flurbiprofen (N=20), and topical benzydamine (N=20). OHQoL was assessed for all study participants with a self-reported eight-item scale that was developed to evaluate pericoronitis. The total OHQoL scores were calculated for each day during the seven-day study period. RESULTS The study group treated with topical benzydamine had a significantly greater improvement in the OHQoL scores compared with the oral diclofenac and oral flurbiprofen groups on the first four days. Comparison of patients treated with diclofenac and flurbiprofen showed no significant differences for all seven days. A significant initial improvement in OHQoL was found on day 1 for the benzydamine group, on day 2 for the flurbiprofen group, and day 3 for the diclofenac group. CONCLUSIONS In this study, topical benzydamine was found to be a more effective alternative to oral NSAID analgesics, diclofenac and flurbiprofen, in improving OHQoL in patients with pericoronitis.


Assuntos
Anti-Inflamatórios não Esteroides/farmacologia , Pericoronite/tratamento farmacológico , Administração Oral , Administração Tópica , Adolescente , Adulto , Benzidamina/farmacologia , Diclofenaco/farmacologia , Feminino , Flurbiprofeno/farmacologia , Humanos , Masculino , Saúde Bucal , Qualidade de Vida , Adulto Jovem
14.
Arch Oral Biol ; 107: 104486, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31374491

RESUMO

OBJECTIVE: The aim of this study was to investigate the association between mandibular third molar position and occurrence of pericoronitis. DESIGN: The systematic review was performed based on PRISMA criteria (Prospero: CRD42018102835). The electronic search was performed in Medline, Virtual Health Library and Web of Science (until August 2018), without language restriction. Two researchers independently selected studies, extracted data, and assessed methodologic quality. Twenty-one articles were included in the review, comprising 6895 patients, with 1913 third mandibular molars being affected by pericoronitis. Ten studies were incuded in meta-analysis. RESULTS: The third molar in vertical position of Winter is the one with the greatest chance of presenting pericoronitis, compared to the other positions, while the horizontal position decreases this chance. There was no significant difference in the chance of pericoronitis between positions I and II of Pell & Gregory (OR: 0.29; IC: 0.07-1.23, I2 = 88%). Third molars classified in position A had greater chance of pericoronitis when compared to those in position B (OR: 7.13; IC: 1.31-38.74, I2 = 93%). The vertical position of the lower third molar is more associated with the occurrence of pericoronitis when compared to the other positions. CONCLUSIONS: Vertical position of the lower third molar is more associated with the occurrence of pericoronitis when compared to the other Winter' positions. Considering Pell and Gregory positions, position A had a greater chance of pericoronitis compared to position B. The prophylactic removal of lower third semi-erupted vertical molar or in position A is indicated to prevent pericoronitis.


Assuntos
Dente Serotino , Pericoronite/etiologia , Dente Impactado/complicações , Humanos , Mandíbula
15.
Recurso na Internet em Português | LIS - Localizador de Informação em Saúde, LIS-bvsms | ID: lis-46426

RESUMO

Os dentes sisos (terceiros molares) são os últimos dentes a se formarem em nossas bocas. Temos 4 dentes sisos, 2 superiores e 2 inferiores que nascem de forma aleatória, e ficam localizados atrás de todos os outros dentes, no término das arcadas dentárias em ambos os lados.


Assuntos
Dente Serotino , Pericoronite , Cirurgiões Bucomaxilofaciais , Saúde Bucal , Odontologia
16.
Curr Microbiol ; 76(7): 799-803, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31028412

RESUMO

A novel facultative anaerobic, Gram-stain-negative coccus, designated strain ChDC B345T, was isolated from human pericoronitis lesion and was characterized by polyphasic taxonomic analysis. The 16S ribosomal RNA gene (16S rDNA) sequence revealed that the strain belonged to the genus Streptococcus. The 16S rDNA sequence of strain ChDC B345T was most closely related to those of  Streptococcus mitis NCTC 12261T (99.5%) and Streptococcus pseudopneumoniae ATCC BAA-960T (99.5%). Complete genome of strain ChDC B345T was 1,972,471 bp in length and the G + C content was 40.2 mol%. Average nucleotide identity values between strain ChDC B345T and S. pseudopneumoniae ATCC BAA-960T or S. mitis NCTC 12261T were 92.17% and 93.63%, respectively. Genome-to-genome distance values between strain ChDC B345T and S. pseudopneumoniae ATCC BAA-960T or S. mitis NCTC 12261T were 47.8% (45.2-50.4%) and 53.0% (51.0-56.4%), respectively. Based on these results, strain ChDC B345T (= KCOM 1679T = JCM 33299T) should be classified as a novel species of genus Streptococcus, for which we propose the name Streptococcus gwangjuense sp. nov.


Assuntos
Pericoronite/microbiologia , Infecções Estreptocócicas/microbiologia , Streptococcus/classificação , Streptococcus/fisiologia , Composição de Bases , DNA Bacteriano/genética , Genoma Bacteriano/genética , Humanos , Hibridização de Ácido Nucleico , Filogenia , RNA Ribossômico 16S/genética , Análise de Sequência de DNA , Especificidade da Espécie , Streptococcus/citologia , Streptococcus/genética
17.
Medicine (Baltimore) ; 98(17): e15312, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31027098

RESUMO

INTRODUCTION: Pericoronitis is a common disease in the eruption phase of third molars, sometimes debilitating, with an impact on the quality of life. The most indicated treatment in the initial phase is the irrigation for cleanliness of the region. In order to reduce the chances of systemic dissemination of the infection and antibiotics use, it is mandatory to test effective treatments in the initial phase of pericoronitis avoiding the evolution of the infectious disease. Photodynamic therapy (PDT) is an interesting alternative because it is an effective antimicrobial treatment that is easy to perform and does not select bacterial resistance. The methylene blue (MB) used in PDT has been studied in an oral formulation, which optimizes the formation of monomers increasing its antimicrobial action. OBJECTIVE: The aim of this study is to evaluate the effectiveness of PDT with MB in an astringent vehicle in pericoronitis on the initial phase in healthy patients through microbiological, clinical, and immune response. The impact of pericoronitis on oral health-related quality of life (OHRQoL) of these patients will also be evaluated. METHOD: In this randomized, controlled, double-blind clinical bioequivalence protocol, 64 healthy patients with pericoronitis will be evaluated. Patients will be randomized into the positive control group (G1) (n = 32): irrigation with sterile saline and PDT (conventional MB at 0.005% concentration and irradiation with low intensity laser λ = 660 nm, 9J per point and radiant exposure of 318 J/cm), and the experimental group (G2) (n = 32): treatment identical to G1, however, MB will be delivered in a new formulation for oral use. Microbiological analysis will be performed by RT-PCR for the bacterium Tannerella forsythia. Gingival crevicular fluid and saliva will be collected to evaluate cytokines by Luminex assay (Luminex Corporation, Austin, TX). The pain (visual analogue scale), swelling and buccal opening (digital caliper), and OHRQoL will also be evaluated through the OHIP-14 questionnaire. The variables will be evaluated in T1 (baseline), T2 (immediately after PDT), and T3 (4th day after PDT). Registration: clinicaltrials.gov NCT03576105. Registered in July 2018.


Assuntos
Azul de Metileno/uso terapêutico , Pericoronite/tratamento farmacológico , Fotoquimioterapia/métodos , Fármacos Fotossensibilizantes/uso terapêutico , Adolescente , Adulto , Método Duplo-Cego , Feminino , Líquido do Sulco Gengival/imunologia , Humanos , Masculino , Pessoa de Meia-Idade , Medição da Dor , Qualidade de Vida , Saliva/imunologia , Adulto Jovem
18.
J. oral res. (Impresa) ; 7(7): 315-318, sept. 22, 2018. ilus
Artigo em Inglês | LILACS | ID: biblio-1121002

RESUMO

Bifid mandibular canal is a variation of the normal anatomy. such anomalies can result in difficult anesthesia while performing surgeries of the posterior mandible under local anesthesia. moreover there is a high chance of damaging the neurovascular bundle leading to complications. here we present a case of a bifid mandibular canal which posed difficulty in achieving appropriate anesthesia. the inferior alveolar nerve is of special interest for maxillofacial and oral surgeons. its relation with mandibular third molar plays an important role while performing disimpaction surgery, in cases of bilateral sagittal split osteotomy, prosthesis placement in resorbed ridges, mandibular trauma procedures, and may be traumatized by penetration of the implant drill.


Assuntos
Humanos , Masculino , Adulto , Mandíbula/anormalidades , Mandíbula/cirurgia , Pericoronite , Radiografia Panorâmica , Tomografia Computadorizada por Raios X , Anestesia Local/métodos , Nervo Mandibular , Dente Serotino/cirurgia
20.
Photodiagnosis Photodyn Ther ; 21: 416-420, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29486353

RESUMO

BACKGROUND: Although antimicrobial efficacy of photodynamic therapy has been studied several times, there is no study investigating its efficacy on pericoronitis. This study aimed to determine whether antimicrobial photodynamic therapy combined with antibiotic therapy is clinically and histologically superior to antibiotic therapy alone in pericoronitis treatment. METHODS: Patients (n = 40) with pericoronitis were divided into two groups (20 patients for each) to receive either antibiotic + indocyanine green + 810 nm wavelength diode laser (antimicrobial photodynamic therapy group) or antibiotic alone. Initial biopsy samples were obtained from the affected tissue of the patients at their first presentation to the clinic before any intervention. The second biopsy samples were obtained on the 3rd day of treatment in both groups from the tissue part not biopsied before; tooth extraction was then performed. All tissue samples were histologically examined to assess inflammatory cell response. Patients' pain (using Visual Analogue Scale) and lymphadenopathy (presence or absence) were clinically evaluated in the first 3 days and on the 7th day of treatment. RESULTS: In the antimicrobial photodynamic therapy group, 100% improvement was achieved regarding pain and lymphadenopathy at the end of the 7th day. Comparison of the inflammatory cell scores of the 2nd biopsy samples between the antibiotic alone and antimicrobial photodynamic therapy groups revealed a significant difference in favor of antimicrobial photodynamic therapy group. CONCLUSIONS: Antimicrobial photodynamic therapy combined with antibiotic therapy for pericoronitis treatment was found to be more successful as compared with the antibiotic therapy alone regarding clinical and histological outcomes.


Assuntos
Antibacterianos/uso terapêutico , Verde de Indocianina/uso terapêutico , Pericoronite/terapia , Fotoquimioterapia/métodos , Fármacos Fotossensibilizantes/uso terapêutico , Adulto , Terapia Combinada , Feminino , Humanos , Lasers Semicondutores/uso terapêutico , Masculino , Adulto Jovem
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