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1.
Braz. j. biol ; 83: e249756, 2023. tab, graf
Artigo em Inglês | LILACS, VETINDEX | ID: biblio-1345533

RESUMO

Abstract Ri chicken is the most popular backyard chicken breed in Vietnam, but little is known about the growth curve of this breed. This study compared the performances of models with three parameters (Gompertz, Brody, and Logistic) and models containing four parameters (Richards, Bridges, and Janoschek) for describing the growth of Ri chicken. The bodyweight of Ri chicken was recorded weekly from week 1 to week 19. Growth models were fitted using minpack.lm package in R software and Akaike's information criterion (AIC), Bayesian information criterion (BIC), and root mean square error (RMSE) were used for model comparison. Based on these criteria, the models having four parameters showed better performance than the ones with three parameters, and the Richards model was the best one for males and females. The lowest and highest value of asymmetric weights (α) were obtained by Bridges and Brody models for each of sexes, respectively. Age and weight estimated by the Richard model were 8.46 and 7.51 weeks and 696.88 and 487.58 g for males and for females, respectively. Differences in the growth curves were observed between males and female chicken. Overall, the results suggested using the Richards model for describing the growth curve of Ri chickens. Further studies on the genetics and genomics of the obtained growth parameters are required before using them for the genetic improvement of Ri chickens.


Resumo O frango Ri é a raça de frango de quintal mais popular do Vietnã, mas pouco se sabe sobre a curva de crescimento dessa raça. Este estudo comparou o desempenho de modelos com três parâmetros (Gompertz, Brody e Logistic) e modelos contendo quatro parâmetros (Richards, Bridges e Janoschek) para descrever o crescimento do frango Ri. O peso corporal do frango Ri foi registrado semanalmente da semana 1 à semana 19. Os modelos de crescimento foram ajustados usando o pacote minpack.lm no software R e o critério de informação de Akaike (AIC); critério de informação bayesiano (BIC) e erro quadrático médio (RMSE) foram usados ​​para comparação de modelos. Com base nesses critérios, os modelos com quatro parâmetros apresentaram melhor desempenho do que os com três parâmetros, sendo o modelo de Richards o melhor para homens e mulheres. O menor e o maior valor dos pesos assimétricos (α) foram obtidos pelos modelos Bridges e Brody para cada um dos sexos, respectivamente. A idade e o peso estimados pelo modelo de Richard foram de 8,46 e 7,51 semanas e 696,88 e 487,58 g para homens e mulheres, respectivamente. Diferenças nas curvas de crescimento foram observadas entre frangos machos e fêmeas. No geral, os resultados sugeriram o uso do modelo de Richards para descrever a curva de crescimento de frangos Ri. Mais estudos sobre a genética e genômica dos parâmetros de crescimento obtidos são necessários antes de usá-los para o melhoramento genético de frangos Ri.


Assuntos
Humanos , Animais , Masculino , Feminino , Galinhas , Modelos Teóricos , Peso Corporal , Teorema de Bayes , Asiáticos , Modelos Biológicos
2.
J Environ Sci (China) ; 124: 472-480, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36182155

RESUMO

Antibiotics have been identified as obesogens contributing to the prevalence of obesity. Moreover, their environmental toxicity shows sex dependence, which might also explain the sex-dependent obesity observed. Yet, the direct evidence for such a connection and the underlying mechanisms remain to be explored. In this study, the effects of tetracycline, which is a representative antibiotic found in both environmental and food samples, on Drosophila melanogaster were studied with consideration of both sex and circadian rhythms (represented by the eclosion rhythm). Results showed that in morning-eclosed adults, tetracycline significantly stimulated the body weight of females (AM females) at 0.1, 1.0, 10.0 and 100.0 µg/L, while tetracycline only stimulated the body weight of males (AM males) at 1.0 µg/L. In the afternoon-eclosed adults, tetracycline significantly stimulated the body weight of females (PM females) at 0.1, 1.0 and 100.0 µg/L, while it showed more significant stimulation in males (PM males) at all concentrations. Notably, the stimulation levels were the greatest in PM males among all the adults. The results showed the clear sex dependence of the obesogenic effects, which was diminished by dysrhythmia. Further biochemical assays and clustering analysis suggested that the sex- and rhythm-dependent obesogenic effects resulted from the bias toward lipogenesis against lipolysis. Moreover, they were closely related to the preference for the energy storage forms of lactate and glucose and also to the presence of excessive insulin, with the involvement of glucolipid metabolism. Such relationships indicated potential bridges between the obesogenic effects of pollutants and other diseases, e.g., cancer and diabetes.


Assuntos
Poluentes Ambientais , Compostos Heterocíclicos , Insulinas , Animais , Antibacterianos/farmacologia , Peso Corporal , Ritmo Circadiano , Drosophila melanogaster , Feminino , Glucose , Insulinas/farmacologia , Lactatos/farmacologia , Masculino , Obesidade/induzido quimicamente , Tetraciclina/toxicidade
3.
An. psicol ; 38(3): [430-438], Oct-Dic. 2022. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-208814

RESUMO

Ante el aumento del porcentaje de sobrepeso y obesidad a nivel mundial, el control de peso es una conducta primordial de promoción de salud. La presente investigación integra el modelo de personalidad Grit, la teoría de la autodeterminación y el modelo transteórico del cambio para tratar de comprender la conducta del control de peso: El objetivo del trabajo consistió en evaluar la personalidad Grit y la motivación como antecedentes psicológicos de las etapas de cambio para el control de peso. Participaron 1351 adultos de México entre 18 y 65 años, quienes cumplimentaron un paquete de cuestionarios con las variables de interés. Los resultados mostraron que la personalidad Grit se relacionó positiva y significativamente con las etapas de mantenimiento, acción, preparación y contemplación y de manera negativa y significativa con la etapa de precontemplación, a través de los tipos de motivación (autónoma, controlada y no motivación), sugiriendo que la personalidad Grit y la motivación son atributos importantes a tener en cuenta en el cambio hacia el control de peso. Este estudio provee de herramientas para la comprensión de la adherencia del control de peso a los profesionales implicados en la consulta nutricional y así promover un mejor abordaje interdisciplinar del sobrepeso y la obesidad.(AU)


Given the increasing percentage of overweight and obesity worldwide, weight control is a primary health-promoting behaviour. Inte-grating Grit personality, self-determination theory, and the transtheoretical model of change, this study evaluates Grit personality and motivation as psychological antecedents of the stages of change towards weight control. A total of 1351 Mexican adults between 18 and 65 years of age completed a packet of questionnaires on the variables of interest. The results showed that Grit personality was positively and significantly related to the mainte-nance, action, preparation, and contemplation stages, and negatively and significantly related to the precontemplation stage, through the types of motivation (autonomous, controlled, and amotivation),suggesting that Grit personality and motivation are important attributes to take into ac-count in the change towards weight control. This study provides tools to help professionals involved in nutritional consultation to understand weight control adherence, thus promoting a better interdisciplinary ap-proach to overweight and obesity.(AU)


Assuntos
Humanos , Motivação , Sobrepeso , Obesidade , Promoção da Saúde , Autonomia Pessoal , Estilo de Vida Saudável , Peso Corporal , Aumento de Peso , Trajetória do Peso do Corpo , Personalidade , Estudos Transversais , México , Psicologia , Psicologia Clínica , Medicina do Comportamento , Inquéritos e Questionários
4.
Clin Nutr ESPEN ; 51: 207-214, 2022 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-36184206

RESUMO

BACKGROUND & AIMS: This study was carried out to determine and compare the effects on anthropometric measurements of the Mediterranean Diet (MD) with daily energy restriction and four different intermittent fasting diets (IFD), which were created as an alternative to MD and gained popularity. METHODS: 360 people aged 18-65 years, with body mass index (BMI) between 27 and 35 kg/m2 participated to the study. Demographic information, anthropometric measurements, physical activity and food consumption records were obtained by the researcher through weekly face-to-face interviews. The study lasted for 13 weeks, the first of which was a trial. Statistical significance level was accepted as 0.05. Participants were randomly assigned to 5 equal groups: Mediterranean Diet (MD), Week on Week off (WOWO), 6-Hour Time-Restricted Eating (TRE-6), 8-Hour Time-Restricted Eating (TRE-8), Alternative Day Diet (ADD). Of the 360 people who participated in the study, 32 (2 TRE-6, 7 WOWO, 1 MD, 16 ADD, 6 TRE-8) dropped out after the trial week. RESULTS: It was determined that throughout the study, body weights, BMI, arm circumferences and waist circumferences in all groups decreased significantly. However, trends in changes in body weights and BMIs did not differ between groups. While the energy, carbohydrate, protein and fat intakes of the participants did not change significantly during the study, fiber consumption increased considerably in the MD and WOWO groups. CONCLUSIONS: It was observed that IFD were not superior to MD in terms of anthropometric measurements. The health effects and long-term consequences are not clear for IFD, unlike MD. For these reasons, it is thought that the most effective nutritional therapy that can be preferred for healthy weight loss is the energy-restricted MD model.


Assuntos
Dieta Mediterrânea , Jejum , Peso Corporal , Carboidratos , Humanos , Obesidade
5.
Clin Nutr ESPEN ; 51: 239-245, 2022 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-36184210

RESUMO

BACKGROUND & AIMS: Estimating resting metabolic rate (RMR) is one of the main determinants of an athlete's energy needs. This study aimed to investigate the RMR of bodybuilding athletes using indirect calorimetry (IC) and compare it with predictive formulas proposed in the scientific literature. METHODS: 71 volunteers divided into four experimental groups: active control group for women (CGW; n = 16); active control group for men (CGM; n = 17); bodybuilder women (BBW; n = 13); and bodybuilder men (BBM; n = 25) were evaluated. The body composition was performed using the bioelectrical impedance (BIA), and the RMR was measured using an IC. The data obtained from the BIA instrument were used to calculate the RMR of all volunteers using six equations. Data normality was tested, and the unpaired t-test compared anthropometric parameters, body composition, and RMR. The Bland-Altman (B&A) plot was used to analyze the agreement between IC, BIA, and predictive equations, and the difference between the methods was calculated. An analysis of covariance (ANCOVA) with Bonferroni post hoc was used for RMR analysis and adjusted for body weight and skeletal muscle mass. RESULTS: The main findings indicated that the Johnstone equation showed a large discrepancy underestimating the RMR of BBW and BBM when compared to IC, and the De Lorenzo and Tinsley equations (a) approached the more accurate analysis method of measuring RMR in BBW and BBM, respectively. CONCLUSION: Professionals who work with bodybuilding and performance will be able to use the present study to improve their nutrition support.


Assuntos
Metabolismo Basal , Composição Corporal , Metabolismo Basal/fisiologia , Índice de Massa Corporal , Peso Corporal , Calorimetria Indireta/métodos , Feminino , Humanos , Masculino
6.
Front Endocrinol (Lausanne) ; 13: 995646, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36187123

RESUMO

Objectives: To investigate the use of once-weekly semaglutide in a real population of people with type 2 diabetes mellitus (T2DM) in three Spanish hospitals. Method: An observational, retrospective and multicenter clinical study was designed that included 166 participants with T2DM, distinguishing between a group naïve to GLP-1RA (n=72) and another switching from another GLP-1RA (n=94), all managed in the outpatient clinical setting. The primary endpoint was the change in HbA1c from baseline to the end of the study. The secondary endpoints included changes in body weight and the proportion of people with T2DM, achieving HbA1c <7.0% and body weight loss >5%. Results: After 24 months of follow-up, the reductions in HbA1c were -0.91 ± 0.7% (p<0.001) in the total cohort, -1.13 ± 1.38% (p<0.019) for GLP-1RA-naïve participants, and -0.74 ± 0.9% (p<0.023) for GLP-1RA-experienced participants. Body weight reductions were -12.42 ± 9.1% in GLP-1RA-naïve participants vs. -7.65 ± 9.7% in GLP-1RA-experienced participants (p<0.001). In the total cohort, 77.1% reached the objective of an HbA1c level <7%, and 12.7% reached between 7.1% and 7.5%. Additionally, 66.9% achieved a weight reduction ≥5%. Of all cohort, 90% received 1 mg of semaglutide once a week. The reported adverse events were consistent with the known safety profile of semaglutide. Conclusions: In routine clinical practice in Spain, the use of semaglutide once a week was associated with statistically significant and clinically relevant improvements in HbA1c and body weight in a wide range of adults with T2DM, without notable adverse effects, which supports real-world use.


Assuntos
Diabetes Mellitus Tipo 2 , Adulto , Instituições de Assistência Ambulatorial , Peso Corporal , Diabetes Mellitus Tipo 2/tratamento farmacológico , Peptídeos Semelhantes ao Glucagon , Hemoglobina A Glicada/análise , Humanos , Hipoglicemiantes/efeitos adversos , Estudos Retrospectivos , Espanha/epidemiologia
7.
Mymensingh Med J ; 31(4): 983-991, 2022 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-36189542

RESUMO

Growth assessment is an essential component of child health surveillance. The most influential tool in the growth assessment is the growth chart. Growth parameters of children are usually interpreted in relation to international standards like the NCHS/1977, CDC/2000 and WHO/2007 growth charts. This comparative study was carried out in the Department of Paediatrics, Mymensingh Medical College, Mymensingh, Bangladesh from November 2014 to October 2015 to compare the growth parameters of children using 2000 CDC standards and 2007 WHO standards. A total of five hundred healthy school children, aged 6 to 10 years were randomly selected proportionately from each class of five government primary schools from Mymensingh city area. Children with physical deformities and acutely ill and those with chronic debilitating diseases were excluded from the study. The mean and median weight, height and BMI were calculated for each age and sex. The median weight, height and BMI were then standardized by converting them to Z-scores (SD) for comparing against known reference values of 2000 CDC and 2007 WHO charts. Among 500 children, 252(50.4%) were boys and 248(49.6%) were girls. The mean age was found 8.0±1.42 years in boys and 8.04±1.42 years in girls. The mean weight was found 24.4±6.36kg in boys and 24.08±6.35kg in girls. The mean height was 125.90±10.16cm in boys and 125.38±10.74cm in girls. The mean weight, height and BMI of boys and girls were found to be lower in all age groups with compared to 2000 CDC standard and 2007 WHO standard but were closer to the WHO standards compared to the CDC standards. According to CDC and WHO in the study it was observed that underweight was found 16.3% and 14.7%, stunting 7.1% and 6.7%, overweight 6.7% and 8.7%, and obese 2.8% and 4.0% respectively in male subjects. On the other hand, in female subjects it was observed that according to CDC chart and WHO chart underweight was found 19.4% and 13.3%, stunting 6.0% and 4.8%, overweight 7.3% and 8.1% and obese 2.0% and 2.0% respectively. The findings in this study imply that growth pattern of Bangladeshi school children is closer with WHO standards and wider from CDC standards.


Assuntos
Sobrepeso , Magreza , Bangladesh/epidemiologia , Estatura , Índice de Massa Corporal , Peso Corporal , Centers for Disease Control and Prevention, U.S. , Criança , Feminino , Transtornos do Crescimento/epidemiologia , Humanos , Masculino , Obesidade/epidemiologia , Magreza/epidemiologia , Estados Unidos , Organização Mundial da Saúde
8.
BMC Res Notes ; 15(1): 314, 2022 Oct 03.
Artigo em Inglês | MEDLINE | ID: mdl-36192762

RESUMO

OBJECTIVE: Memory impairment is a serious problem that has a significant negative impact on survival and quality of life. When used for a long time, drugs used to treat memory loss become less effective and have more side effects, making therapy more difficult. Different medicinal plants are now being highlighted because of their valuable applications and low risk of adverse effects. Moringa oleifera is one of these plants that has gained much attention due to its diverse biological functions. The study aimed to determine the effects of Moringa oleifera on working memory in memory-impaired Wistar rats. RESULTS: For this experimental study, 30 male Wistar rats having 150-250 g bodyweight were divided equally into three groups: Group-I/normal memory group (treated with oral normal saline 5 ml/kg body weight), Group-II/memory-impaired group (induced by intraperitoneal ketamine 15 mg/kg body weight), and Group-III/experimental group (treated with oral Moringa oleifera 200 mg/kg bodyweight and intraperitoneal ketamine 15 mg/kg body weight). The experimental group showed significantly fewer working memory errors than the memory-impaired group. The experimental group also provides the lowest variability of WMEs among groups. Thus, the study concludes that M. oleifera can prevent ketamine-induced memory impairment in Wistar rats.


Assuntos
Ketamina , Moringa oleifera , Animais , Peso Corporal , Memória de Curto Prazo , Extratos Vegetais , Folhas de Planta , Qualidade de Vida , Ratos , Ratos Wistar , Solução Salina
9.
Mediators Inflamm ; 2022: 2689918, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36193415

RESUMO

Objective: To investigate the mechanism of Connexin 37 (Cx37) and Kv1.3 pathways in atherosclerosis (AS). Methods: ApoE-/- mice were given a high-fat diet to establish atherosclerosis (AS) model, and macrophages in mice were isolated and extracted to transfect Cx37 vectors with silencing or overexpressing, and Kv1.3 pathway blockers were used to inhibit the pathway activity. The indexes of body weight, blood glucose, and blood lipid of mice were collected. The protein and mRNA expression levels of Cx37 and Kv1.3 were detected by reverse transcription-PCR (RT-PCR), Western blot, and immunofluorescence technique. Oil red O staining was used to observe plaque area. Masson staining was used to detect collagen content. The concentrations of chemokine CCL7 were quantified using the ELISA kits. CCK8 was used to detect cell proliferation. Results: Cx37 and Kv1.3 were highly expressed in macrophages of AS mice, and the expression of Kv1.3 and CCL7 decreased after Cx37 was silenced, and the proliferation of macrophages was also decreased. Wild-type mice and AS model mice were treated with Cx37 overexpression vectors and Kv1.3 pathway blocking, and it was found that Cx37 overexpression could improve the blood lipid and blood glucose levels and increase the area of AS in AS mice. However, blocking the activity of Kv1.3 pathway can reduce the levels of blood lipid and blood glucose, increase the body weight of mice, and reduce the area of AS mice. Blocking the activity of Kv1.3 pathway can slow down the plaque development of AS mice and make its indexes close to wild-type mice. And the use of Kv1.3 pathway blockers on the basis of overexpression of Cx37 indicated that inhibition of Kv1.3 pathway activity did not affect the expression of Cx37, but could inhibit the collagen content in the plaque area of AS mice, inhibit the expression of chemokine CCL7, and reverse the effect of Cx37 overexpression. Conclusion: Cx37 can improve the activity of macrophages by regulating the expression of chemokines and the activity of Kv1.3 pathway in AS mice, and enrich macrophages in inflammatory tissues and expand the area of plaque formation.


Assuntos
Aterosclerose , Placa Aterosclerótica , Animais , Apolipoproteínas E/genética , Aterosclerose/metabolismo , Glicemia , Peso Corporal , Quimiocina CCL7 , Colágeno , Conexinas , Camundongos , Placa Aterosclerótica/metabolismo , RNA Mensageiro
10.
Eur J Histochem ; 66(4)2022 Oct 03.
Artigo em Inglês | MEDLINE | ID: mdl-36190398

RESUMO

Cisplatin (CDDP) has been widely used in cancer therapy, but it has been linked to side effects such as nephrotoxicity. Crocin is a carotenoid found in crocus and gardenia flowers that has been shown to have anti-oxidant properties, inhibit tumor growth, and provide neuroprotection. The purpose of this study was to investigate the protective effect of crocin against CDDP-induced nephrotoxicity in a mouse model. Kunming mice were administered orally with crocin for 7 days at the dose of 6.25 mg/kg and 12.5 mg/kg per body weight daily and were injected with CDDP via intraperitoneal route at the dose of 10 mg/kg per body weight. Using commercial kits, the oxidative stress markers glutathione, malondialdehyde, catalase, glutathione peroxidase, and superoxide dismutase were measured in the kidneys of mice. Immunohistochemistry was used to assess the levels of p53, cleaved caspase-3, and phospho-p38 mitogen-activated protein kinase in the kidneys. Crocin significantly reduced CDDP-induced changes in serum creatinine and blood urea nitrogen levels, according to the findings. Crocin reduced malondialdehyde levels and increased glutathione, glutathione peroxidase, catalase, and superoxide dismutase levels in CDDP-induced lipid peroxidation. Crocin also significantly inhibited p38 mitogen-activated protein kinase activation, p53 expression, and caspase-3 cleavage. In conclusion, crocin protects against CDDP-induced oxidative stress and nephrotoxicity by attenuating the activation of p38 mitogen-activated protein kinase and caspase-3 cleavage.


Assuntos
Antineoplásicos , Cisplatino , Animais , Antineoplásicos/toxicidade , Antioxidantes/farmacologia , Antioxidantes/uso terapêutico , Peso Corporal , Carotenoides/metabolismo , Carotenoides/farmacologia , Carotenoides/uso terapêutico , Caspase 3/metabolismo , Catalase/metabolismo , Cisplatino/metabolismo , Cisplatino/toxicidade , Creatinina/metabolismo , Creatinina/farmacologia , Modelos Animais de Doenças , Glutationa/metabolismo , Glutationa/farmacologia , Glutationa Peroxidase/metabolismo , Glutationa Peroxidase/farmacologia , Rim/metabolismo , Malondialdeído/metabolismo , Malondialdeído/farmacologia , Camundongos , Estresse Oxidativo , Superóxido Dismutase/metabolismo , Superóxido Dismutase/farmacologia , Proteína Supressora de Tumor p53/metabolismo , Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo , Proteínas Quinases p38 Ativadas por Mitógeno/farmacologia
11.
Rev Paul Pediatr ; 41: e2021204, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36102398

RESUMO

OBJECTIVE: To identify the prevalence of weight dissatisfaction among adolescents aged 10-19 years and stratify the analysis by sex. DATA SOURCE: A literature review of cross-sectional studies among healthy adolescents was performed. The U.S. National Library of Medicine/National Institutes of Health (PubMed), Ovid® (Wolters Kluwer), The Cumulative Index to Nursing and Allied Health Literature (CINAHL), and American Psychological Association (PsycINFO®) databases were searched between May 2019 and January 2020. DATA SYNTHESIS: Initially, 3,700 records were identified, and 10 papers were obtained through other sources. After the removal of duplicates, 1,732 records were screened based on the titles and abstracts, and 126 were preselected for full-text analysis. After the application of the eligibility criteria, 34 papers were included in the present review. The studies were published between 1997 and 2020. The sample size ranged from <150 to >103,000 adolescents. The prevalence of weight dissatisfaction ranged from 18.0 to 56.6% in both sexes (10.8-82.5% among boys and 19.2-83.8% among girls). CONCLUSIONS: Based on the findings of the present systematic review, the prevalence of weight dissatisfaction is high among adolescents, especially girls. Such information can contribute to the planning of health and education programs addressing the issue of weight in adolescents.


Assuntos
Insatisfação Corporal , Imagem Corporal , Adolescente , Imagem Corporal/psicologia , Peso Corporal , Estudos Transversais , Feminino , Humanos , Masculino , Prevalência
12.
Trop Anim Health Prod ; 54(5): 298, 2022 Sep 14.
Artigo em Inglês | MEDLINE | ID: mdl-36103006

RESUMO

The indigenous chicken production has become an integral part of smallholder farming systems in Africa. Their products are preferred due to their taste and flavor; crossbreeding using exotic breeds can improve the productivity of these chickens without sacrificing their genetic merits. This study was aimed at improving the Wassache chicken. F1 generations of the crosses between the Wassache and Sasso chickens were simultaneously evaluated for growth traits, mortality, and carcass yield in a pure and reciprocal cross design. Data on body weight, performance, and mortality were collected on 451 birds (Sasso × Sasso [SS] = 110; Wassache × Wassache [WW] = 113; Sasso × Wassache [SW] = 113 and Wassache × Sasso [WS] = 115) for 12 weeks. On the 12th week of the study, 20 birds from each genotype were dissected to determine carcass yield. All data collected were analyzed using Minitab 19. The results showed significantly higher (P < 0.05) values reported for the SS genotype in all parameters studied. Likewise, the reciprocal crosses showed higher performance in growth and carcass traits next to pure Sasso. However, the feed conversion ratio and dressing percentage of the hybrids did not differ (P < 0.05) from those of the SS and WW genotypes. Within the reciprocal crosses, there was no significant difference (P > 0.05) in all parameters measured except for hatch weight where the WS showed a higher (P < 0.05) hatch weight compared to the SW cross. The study encourages the crossbreeding of the Wassache and Sasso chickens for improved meat production in this region.


Assuntos
Galinhas , Carne , Animais , Peso Corporal , Galinhas/genética , Genótipo , Hibridização Genética , Carne/análise
13.
Nutrients ; 14(17)2022 Aug 26.
Artigo em Inglês | MEDLINE | ID: mdl-36079778

RESUMO

Development of predictive computational models of metabolism through mechanistic models is complex and resource demanding, and their personalization remains challenging. Data-driven models of human metabolism would constitute a reliable, fast, and continuously updating model for predictive analytics. Wearable devices, such as smart bands and impedance balances, allow the real time and remote monitoring of physiological parameters, providing for a flux of data carrying information on user metabolism. Here, we developed a data-driven model of end-user metabolism, the Personalized Metabolic Avatar (PMA), to estimate its personalized reactions to diets. PMA consists of a gated recurrent unit (GRU) deep learning model trained to forecast personalized weight variations according to macronutrient composition and daily energy balance. The model can perform simulations and evaluation of diet plans, allowing the definition of tailored goals for achieving ideal weight. This approach can provide the correct clues to empower citizens with scientific knowledge, augmenting their self-awareness with the aim to achieve long-lasting results in pursuing a healthy lifestyle.


Assuntos
Metabolismo Energético , Dispositivos Eletrônicos Vestíveis , Peso Corporal , Dieta , Previsões , Humanos
14.
Pak J Biol Sci ; 25(8): 741-747, 2022 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-36098200

RESUMO

<b>Background and Objective:</b> The growth hormone (GH) gene plays a role in meat growth and has been shown to increase the growth rate and carcass composition after being given GH. For this function, this gene is used as a strong candidate for genetic markers for meat growth traits. The research objective was to map the growth hormone (GH) gene of the bodyweight of Krui cattle in the Pesisir Barat Regency. <b>Materials and Methods:</b> This research used 30 blood samples of 30 Krui cattle. The method used was by taking quantitative data and blood samples from adult Krui cattle in Pesisir Barat Regency and then the blood samples were analyzed by DNA isolation method. PCR amplification used was a pair of GH-Forward primers: 5 'ATC CAC ACC CCC TCC ACA CAGT 3' and GH- reverse: 5 'CAT TTT CCA CCC TCC CCT ACA G 3', as well as digestion using the RFLP method at the Laboratory of Animal Breeding and Genetics of Universitas Gadjah Mada, Yogyakarta. Association between genotype and body weight was analyzed descriptively. <b>Results:</b> The results showed that Krui cattle had polymorphic genes with three genotypes found, namely: CC, CT and TT. Cattle with CT genotype had the largest average body weight or meat production compared to those with other genotypes. <b>Conclusion:</b> These results indicated that the GH gene identifier has strong evidence that it can be used as a selection tool with the help of genotypes of body weight traits of Krui meat production in the Pesisir Barat Regency. Krui cattle with CT genotype can be developed further because it has high economic value with high average body weight and meat production.


Assuntos
Hormônio do Crescimento , Animais , Peso Corporal/genética , Bovinos/genética , Genótipo , Hormônio do Crescimento/genética , Indonésia , Fenótipo
15.
PLoS One ; 17(9): e0272020, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36103487

RESUMO

This study tracked and recorded the weight changes of 13 captive Sunda pangolin cubs from lactation to maturity to explored the appropriate weaning time and reveal the rules of its weight growth. SPSS 25.0 was used to build a cubic equation model to fit the body weight change rules of 4 individuals who nonvoluntarily ingested artificial feed (NIAF) at 127 days after birth and 5 individuals who voluntarily ingested artificial feed (VIAF) at 86-108 days after birth. The body weight of NIAF cubs aged 0-120 days and VIAF cubs aged 0-150 days were estimated according to the fitting model. An independent sample T-test was performed on the mean body weight of the two groups during the late lactation period. The results showed that at 105 days after birth, the body weight of the VIAF group was significantly higher than that of the NIAF group (P = 0.049), and the body weight of the VIAF group was extremely significantly higher than that of the NIAF group at 114 days (P = 0.008); The peak cumulative body weight of the NIAF cubs during lactation appeared around 130 days of age (n = 3); The mortality rate was 66.7% (n = 3) after about 150 days if the feed was continuously consumed nonvoluntarily. It was concluded that the milk secretion period of the mother is about 0-5 months after giving birth; the weaning period of the cubs should be 4-5 months after birth. If the cubs don't follow the mother to eat artificial feed for 3 months after birth, it can start be induced with artificial diet which adds termites, and the time point cannot be later than 130 days, otherwise it is not conducive to the survival of the cubs; When sexually mature, the body length and body weight of female cubs account for about 84% and 60% of the adult, respectively; the body maturity and body weight of female cubs tend to be stable about 15.3 months and 16.4 months, respectively. Finally, a special needle-shaped nipples and nursing patterns of female Sunda pangolins were also recorded in this study. These findings play an important role in guiding the nursing of captive Sunda pangolin cubs and other pangolin cubs. It is expected to improve the survival rate of the cubs by exploring the appropriate weaning time and the rules of weight growth. By scientifically planning the reproductive cycle of the female Sunda pangolins, our goal is to expand the population size and eventually release to the wild, meanwhile improving knowledge of this critically endangered species.


Assuntos
Espécies em Perigo de Extinção , Pangolins , Animais , Peso Corporal , Feminino , Humanos , Lactação , Gravidez , Desmame
16.
J Coll Physicians Surg Pak ; 32(9): 1175-1180, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-36089716

RESUMO

OBJECTIVE: To determine the protective role of irisin in attenuating nicotine-induced oxidative stress in vascular tissue in mice. STUDY DESIGN: Experimental study. PLACE AND DURATION OF STUDY: Foundation University, Islamabad, Pakistan, from January 2019 to June 2020. METHODOLOGY: Thirty healthy BALB/c mice were divided into 3 groups. Group 1 was control, group II received nicotine 2 mg/Kg body weight intraperitoneally for 28 days, and group III, in addition, received r-irisin 0.5 µg/g body weight /day via tail vein, for the last 14 days. The tissue anti-oxidant enzymes (SOD, CAT, and GR) and lipid peroxidation marker (TBARS) were estimated. Aortic endothelium was analysed for atherosclerotic changes. The significant difference across groups was calculated using ANOVA. RESULTS: Group II showed statistically significant increase in lipid peroxidation marker (TBARS) levels (1059.04±32.31 ng/ml, p<0.001) and reduction in anti-oxidative enzymes (SOD, CAT and GR) levels (5479.24±25.38 pg/ml, 11.51±0.24 ng/ml and 1924.88±31.23 ng/ml, p<0.001) in aortic tissue homogenate as compared to group I. In Group III, with co- administration of r-irisin, significant improvement in antioxidant enzymes i.e. SOD, CAT, and GR levels (7958.70±110.54 pg/ml, 20.86±0.57 ng/ml, and 2897.18±52.93 ng/ml) and reduction in TBARS levels (239.14±19.90 ng/ml) was observed as compared to Group II (p<0.001). Endothelial damage manifested to type IV on histological examination. Co-administration of r-irisin in group III showed significant improvement in histological grading (only Type I and II lesions were seen). CONCLUSION: Exogenous administration of irisin improves anti-oxidant enzyme levels, ameliorates nicotine-induced oxidative stress, and endothelial dysfunction in the BALB/c mice. KEY WORDS: Irisin/FNDC-5, Oxidative stress, Anti-oxidant enzymes, Endothelial dysfunction, Atherosclerosis.


Assuntos
Aterosclerose , Fibronectinas , Animais , Antioxidantes/farmacologia , Aterosclerose/induzido quimicamente , Peso Corporal , Fibronectinas/farmacologia , Humanos , Camundongos , Camundongos Endogâmicos BALB C , Nicotina/farmacologia , Estresse Oxidativo , Superóxido Dismutase/metabolismo , Substâncias Reativas com Ácido Tiobarbitúrico
17.
Wiad Lek ; 75(8 pt 1): 1932-1937, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-36089882

RESUMO

A 17-year-old female patient was admitted to the psychoneurological department of Kyiv Clinical Railway Hospital No. 1, due to deterioration of her mental state, a significant decrease in body weight, and no effect of outpatient treatment. The complex treatment program, directed on the correction of all multidimensional disorders with the preliminary psychodiagnostics examination of the patient and her parents according to the FACES-III, DERS, which were monitored in dynamics during the 3,6,9 and 12 months of treatment, was applied. The patient's parents were additionally assessed by TAS, HADS, and the CQLS. We noted that the functioning of the family as a whole influenced the emotional regulation of each of its members; in turn, the emotional regulation of the parents had a direct influence on the patient's emotional regulation, and the patient's emotional regulation influenced changes body weight. The patient's personal psychotherapy and ABFT allowed us to decrease the gap in the attachment relationship between parents and patient and create a safe emotional base for reducing the stress of the relationship with parents at home, which was confirmed by positive dynamics of FACES-III, decrease in difficulties of emotional regulation on DERS and restoration of the patient's normal weight.


Assuntos
Anorexia Nervosa , Regulação Emocional , Adolescente , Anorexia Nervosa/complicações , Anorexia Nervosa/psicologia , Anorexia Nervosa/terapia , Peso Corporal , Emoções , Feminino , Humanos , Pais
18.
Nutrients ; 14(17)2022 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-36079841

RESUMO

MED-02 is a complex supplement containing two probiotic strains, Limosilactobacillus fermentum MG4231 and MG4244, isolated from humans. The anti-obesity effects and safety profile of MED-02 were assessed in overweight and obese subjects. In this randomized, double-blinded, placebo-controlled, multicenter study, 100 healthy obese and overweight subjects aged 19-65 years with a body mass index (BMI) between 25 and 31.9 kg/m2 were recruited and randomized to receive a placebo or MED-02 (5 × 109 CFU/day). After 12 weeks of consumption, body fat mass (-1166.82 g vs. -382.08 g; p = 0.024) and body fat percentage (-0.85% vs. -0.11%; p = 0.030), as evaluated by dual-energy X-ray absorptiometry (DEXA) and body weight (-2.06 kg vs. -1.22 kg; p = 0.041), were significantly reduced in the MED-02 group compared to the placebo group. The safety profile did not differ among the groups. No serious adverse effects were observed in either group. These results suggest that MED-02 is a safe and beneficial probiotics that reduces body fat and body weight in overweight or obese individuals.


Assuntos
Lactobacillus fermentum , Probióticos , Tecido Adiposo , Índice de Massa Corporal , Peso Corporal , Método Duplo-Cego , Humanos , Obesidade/tratamento farmacológico , Sobrepeso/tratamento farmacológico , Probióticos/uso terapêutico
19.
Nutrients ; 14(17)2022 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-36079907

RESUMO

The problem of overweight and obesity is a growing phenomenon in the entire population. Obesity is associated with many different metabolic disorders and is directly associated with an increased risk of death. The aim of the study was to assess the changes in body composition and physical fitness in children participating in an integrated weight-loss programme and to analyse the possible relationship between changes in body composition and improvements in fitness. Participants of the study were recruited from the "6-10-14 for Health"-multidisciplinary intervention programme for children aged 6 to 15 years old. A total of 170 patients qualified for the study, and 152 patients were enrolled. Statistically significant changes in body composition were found after the end of the intervention program, as measured by both BIA (bioimpedance) and DXA (Dual Energy X-ray Absorptiometry). The differences in KPRT (Kasch Pulse Recovery Test) results at baseline and after intervention are positively correlated with the difference in fat mass between baseline and the after-intervention measure. Improving physical fitness is positively correlated with a decrease in FM (fat mass) and an increase in FFM (fat-free mass) measured in both absolute values and %. Both BIA and DXA methods proved to be equally useful for measuring body composition.


Assuntos
Programas de Redução de Peso , Absorciometria de Fóton/métodos , Adolescente , Composição Corporal , Índice de Massa Corporal , Peso Corporal , Criança , Impedância Elétrica , Humanos , Obesidade , Desempenho Físico Funcional , Aumento de Peso
20.
Nutrients ; 14(17)2022 Sep 04.
Artigo em Inglês | MEDLINE | ID: mdl-36079913

RESUMO

(1) Background: Nutritional support is one of the most important cornerstones in the management of patients with severe burns, but the carbohydrate-to-fat ratios in burn nutrition therapy remain highly controversial. In this study, we aimed to discuss the effects of different ratios of carbohydrate-fat through enteral nutrition on the metabolic changes and organ damage in burned rats. (2) Methods: Twenty-four burned rats were randomly divided into 5%, 10%, 20% and 30% fat nutritional groups. REE and body weight were measured individually for each rat daily. Then, 75% of REE was given in the first week after burns, and the full dose was given in the second week. Glucose tolerance of the rats was measured on days 1, 3, 7, 10 and 14. Blood biochemistry analysis and organ damage analysis were performed after 7 and 14 days of nutritional therapy, and nuclear magnetic resonance (NMR) and insulin content analysis were performed after 14 days. (3) Results: NMR spectra showed significant differences of glucose, lipid and amino acid metabolic pathways. The energy expenditure increased, and body weight decreased significantly after burn injury, with larger change in the 20%, 5% and 30% fat groups, and minimal change in the 10% fat group. The obvious changes in the level of plasma protein, glucose, lipids and insulin, as well as the organ damage, were in the 30%, 20% and 5% fat groups. In relative terms, the 10% fat group showed the least variation and was closest to normal group. (4) Conclusion: Lower fat intake is beneficial to maintaining metabolic stability and lessening organ damage after burns, but percentage of fat supply should not be less than 10% in burned rats.


Assuntos
Queimaduras , Insulinas , Animais , Peso Corporal , Queimaduras/metabolismo , Queimaduras/terapia , Carboidratos , Nutrição Enteral , Glucose , Ratos
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