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1.
Biomed Res Int ; 2021: 2754407, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34917681

RESUMO

Background: Malaria is one of the leading causes of morbidity and mortality especially in pregnant women and under-five-year-old children. However, data on the prevalence among delivering mothers, potential fetal transmission, and associated birth outcomes is lacking in Ethiopia. Objective: To assess the prevalence of Plasmodium infection from peripheral, placental, and cord blood samples among delivering mothers in Kuch health center, Northwest Ethiopia. Methods: An institution-based cross-sectional study was conducted among 218 delivering mothers from February to May 2021 in Kuch health center. Data on sociodemographic characteristics and clinical and obstetric history of mothers were collected using a structured questionnaire. Giemsa stained blood films from maternal capillary and placental and umbilical cord blood were examined for plasmodium infection. Data were analyzed using Statistical Package for the Social Sciences version 23 software package. Results: The prevalence of maternal, placental, and umbilical cord malaria was 6.4% (14/218), 2.3% (5/218), and 0.5% (1/218), respectively. Plasmodium falciparum and Plasmodium vivax accounted 3.7% (8/218) and 2.8% (6/218), respectively, in maternal peripheral blood but only Plasmodium falciparum was detected in placental and umbilical cord blood samples. Maternal malaria had significant association with primigravida (χ 2 = 12.611, p = 0.002) and low birth weight (χ 2 = 8.381, p = 0.004). Placental malaria was also significantly associated with low birth weight (χ 2 = 32.255, p ≤ 0.001). Conclusion: The prevalence of malaria among delivering mothers was considerable. Maternal peripheral malaria had a significant association with gravidity and birth weight. Placental and umbilical cord malaria also had a significant association with birth weight. Pregnant mothers should be examined for malaria and receive appropriate treatment to prevent adverse birth outcomes.


Assuntos
Malária/epidemiologia , Mães/estatística & dados numéricos , Adulto , Peso ao Nascer/fisiologia , Estudos Transversais , Etiópia/epidemiologia , Feminino , Sangue Fetal/parasitologia , Feto/parasitologia , Número de Gestações/fisiologia , Instalações de Saúde/estatística & dados numéricos , Humanos , Placenta/parasitologia , Plasmodium falciparum/patogenicidade , Plasmodium vivax/patogenicidade , Gravidez , Complicações na Gravidez/parasitologia , Cuidado Pré-Natal/estatística & dados numéricos , Prevalência , Cordão Umbilical/parasitologia , Adulto Jovem
2.
Invest Ophthalmol Vis Sci ; 62(14): 9, 2021 11 01.
Artigo em Inglês | MEDLINE | ID: mdl-34757404

RESUMO

Purpose: Low birth weight (BW) is associated with alterations of foveal shape development in childhood-leading to an increased retinal thickness of the fovea. The aim of the present study was to assess whether BW has a long-term effect on foveal retinal thickness (RT) and is still present in adulthood. Methods: In the German population-based Gutenberg Health Study (GHS), participants were examined with spectral-domain optical coherence tomography. The association between self-reported BW and RT in the foveolar and perifoveal locations was assessed. Multivariable linear regression analyses with adjustment for potential confounders and grading of foveal hypoplasia were performed. Results: Overall, RT measurements and self-reported BW were available for 2,539 participants (1300 female, mean age 54.5 ± 9.7 years). The absolute foveolar RT was 239.6 ± 25.8 µm, 232.2 ± 20.1 µm and 234.8 ± 21.0 µm, respectively, in the low (<2500 g), normal (2500-4000 g) and high (>4000 g) BW groups (P < 0.001). After adjustment for confounders, an association was observed between lower BW and increased foveolar thickness (B = -0.35 [95% confidence interval {CI}: -0.49; -0.20] µm/100 g; P < 0.001), whereas only a weak association with RT was observed with the nasal (P = 0.010), temporal (P = 0.011), and inferior (P = 0.021) quadrants in the 1 mm distance, with no association in the 2 mm distance to the fovea. Foveal hypoplasia grade 1 was more frequent in the low BW group (6.8%) compared to the normal (0.9%) and high BW group (1.2%). Conclusions: This study provides evidence of an association between lower BW and increased foveolar thickness and foveal hypoplasia, indicating that prenatal growth may affect macular morphology, which in turn may persist until adulthood and predispose to retinal disease later in life.


Assuntos
Peso ao Nascer/fisiologia , Anormalidades do Olho/fisiopatologia , Fóvea Central/anormalidades , Fóvea Central/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Anormalidades do Olho/diagnóstico por imagem , Feminino , Seguimentos , Fóvea Central/diagnóstico por imagem , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Tomografia de Coerência Óptica , Acuidade Visual
3.
PLoS One ; 16(10): e0258894, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34673829

RESUMO

INTRODUCTION: Little is known about the influence of hyperglycemia first detected in pregnancy (HFDP) on weight outcomes in exposed offspring in Africa. We investigated the influence of maternal blood glucose concentrations during pregnancy on offspring weight outcomes at birth and preschool age, in offspring exposed to HFDP, in South Africa. RESEARCH DESIGN AND METHODS: Women diagnosed with HFDP had data routinely collected during the pregnancy and at delivery, at a referral hospital, and the offspring followed up at preschool age. Maternal fasting, oral glucose tolerance test 1 and 2-hour blood glucose were measured at diagnosis of HFDP and 2-hour postprandial blood glucose during the third trimester. Offspring were classified as either those exposed to diabetes first recognized in pregnancy (DIP) or gestational diabetes (GDM). At birth, neonates were classified into macrosomia, low birth weight (LBW), large for gestational age (LGA), appropriate (AGA) and small for gestational age (SGA)groups. At preschool age, offspring had height and weight measured and Z-scores for weight, height and BMI calculated. RESULTS: Four hundred and forty-three neonates were included in the study at birth, with 165 exposed to DIP and 278 exposed to GDM. At birth, the prevalence of LGA, macrosomia and LBW were 29.6%, 12.2% and 7.5%, respectively, with a higher prevalence of LGA and macrosomia in neonates exposed to DIP. At pre-school age, the combined prevalence of overweight and obesity was 26.5%. Maternal third trimester 2-hour postprandial blood glucose was significantly associated with z-scores for weight at birth and preschool age, and both SGA and LGA at birth. CONCLUSION: In offspring exposed to HFDP, there is a high prevalence of LGA and macrosomia at birth, and overweight and obesity at preschool age, with higher prevalence in those exposed to DIP, compared to GDM. Maternal blood glucose control during the pregnancy influences offspring weight at birth and preschool age.


Assuntos
Peso ao Nascer/fisiologia , Glicemia , Peso Corporal/fisiologia , Hiperglicemia/fisiopatologia , Efeitos Tardios da Exposição Pré-Natal/fisiopatologia , Adulto , Pré-Escolar , Feminino , Teste de Tolerância a Glucose , Humanos , Hiperglicemia/sangue , Recém-Nascido , Masculino , Gravidez , Complicações na Gravidez/sangue , Complicações na Gravidez/fisiopatologia , África do Sul , Adulto Jovem
4.
PLoS One ; 16(10): e0259080, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34710152

RESUMO

We aimed to evaluate risk factors for growth failure in very low birth weight (VLBW) infants at 18-24 months of corrected age (follow-up1, FU1) and at 36 months of age (follow-up2, FU2). In this prospective cohort study, a total of 2,943 VLBW infants from the Korean Neonatal Network between 2013 and 2015 finished follow-up at FU1. Growth failure was defined as a z-score below -1.28. Multiple logistic regression was used to analyze risk factors for growth failure after dividing the infants into small for gestational age (SGA) and appropriate for gestational age (AGA) groups. Overall, 18.7% of infants were SGA at birth. Growth failure was present in 60.0% at discharge, 20.3% at FU1, and 35.2% at FU2. Among AGA infants, male sex, growth failure at discharge, periventricular leukomalacia, treatment of retinopathy of prematurity, ventriculoperitoneal shunt status and treatment of rehabilitation after discharge were independent risk factors for growth failure at FU1. Among SGA infants, lower birth weight, pregnancy-induced hypertension, and treatment of rehabilitation after discharge were independent risk factors for growth failure at FU1. Mean weight z-score graphs from birth to 36 month of age revealed significant differences between SGA and non-SGA and between VLBW infants and extremely low birth weight infants. Growth failure remains an issue, and VLBW infants with risk factors should be closely checked for growth and nutrition.


Assuntos
Insuficiência de Crescimento/etiologia , Transtornos do Crescimento/etiologia , Recém-Nascido de muito Baixo Peso/crescimento & desenvolvimento , Peso ao Nascer/fisiologia , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Recém-Nascido Pequeno para a Idade Gestacional/crescimento & desenvolvimento , Masculino , Gravidez , Estudos Prospectivos , República da Coreia , Fatores de Risco
5.
Int J Mol Sci ; 22(19)2021 Sep 24.
Artigo em Inglês | MEDLINE | ID: mdl-34638634

RESUMO

The hyperfiltration theory has been used to explain the mechanism of low birth weight (LBW)-related nephropathy. However, the molecular changes in the kidney proteome have not been defined in this disease, and early biomarkers are lacking. We investigated the molecular pathogenesis of LBW rats obtained by intraperitoneal injection of dexamethasone into pregnant animals. Normal-birth-weight (NBW) rats were used as controls. When the rats were four weeks old, the left kidneys were removed and used for comprehensive label-free proteomic studies. Following uninephrectomy, all rats were fed a high-salt diet until 9 weeks of age. Differences in the molecular composition of the kidney cortex were observed at the early step of LBW nephropathy pathogenesis. Untargeted quantitative proteomics showed that proteins involved in energy metabolism, such as oxidative phosphorylation (OXPHOS), the TCA cycle, and glycolysis, were specifically downregulated in the kidneys of LBW rats at four weeks. No pathological changes were detected at this early stage. Pathway analysis identified NEFL2 (NRF2) and RICTOR as potential upstream regulators. The search for biomarkers identified components of the mitochondrial respiratory chain, namely, ubiquinol-cytochrome c reductase complex subunits (UQCR7/11) and ATP5I/L, two components of mitochondrial F1FO-ATP synthase. These findings were further validated by immunohistology. At later stages of the disease process, the right kidneys revealed an increased frequency of focal segmental glomerulosclerosis lesions, interstitial fibrosis and tubular atrophy. Our findings revealed proteome changes in LBW rat kidneys and revealed a strong downregulation of specific mitochondrial respiratory chain proteins, such as UQCR7.


Assuntos
Recém-Nascido de Baixo Peso/metabolismo , Nefropatias/metabolismo , Proteoma/metabolismo , Animais , Animais Recém-Nascidos/metabolismo , Biomarcadores/metabolismo , Peso ao Nascer/fisiologia , Complexo III da Cadeia de Transporte de Elétrons/metabolismo , Feminino , Rim/metabolismo , Masculino , Fator 2 Relacionado a NF-E2/metabolismo , Fosforilação Oxidativa , Gravidez , Proteômica/métodos , Proteína Companheira de mTOR Insensível à Rapamicina/metabolismo , Ratos
6.
Sci Rep ; 11(1): 16093, 2021 08 09.
Artigo em Inglês | MEDLINE | ID: mdl-34373470

RESUMO

Most published newborn growth references are based on conventional monitoring data that usually included both low- and high-risk pregnancies. We sought to develop a set of neonatal growth standards constructed from only a large sample of low-risk pregnancies. A total of 24,375 naturally conceived singleton live births with gestational ages of 24-42 weeks were collected in 69 hospitals in thirteen Chinese cities between 2015 and 2018. Unhealthy infants or those with high-risk mother were excluded. Smoothed percentile curves of six anthropometric indicators were established using the Generalized Additive Model for Location, Scale and Shape. The 3rd, 10th, 25th, 50th, 75th, 90th, and 97th percentile references for birth weight, length, head circumference, weight/length, body mass index, and ponderal index were calculated for neonates with gestational ages of 24-42 weeks. This set of neonatal growth standards with six anthropometric indicators can provide more tools for growth and nutrition assessment and body proportionality in neonatal clinical practice. These standards might also help to show the differences between growth curves based on low-risk and mixed low- and high-risk pregnancies.


Assuntos
Peso ao Nascer/fisiologia , Estatura/fisiologia , Desenvolvimento Fetal/fisiologia , Adulto , Antropometria/métodos , Índice de Massa Corporal , Cefalometria/normas , China , Cidades , Estudos Transversais , Feminino , Idade Gestacional , Humanos , Recém-Nascido , Masculino , Valores de Referência
7.
Afr Health Sci ; 21(1): 349-356, 2021 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-34394316

RESUMO

Background: Length at birth is important for evaluating childhood growth and development. It is of interest in Pediatrics because of its implications for perinatal and postnatal morbidity and mortality. Predicting birth length will be useful in anticipating and managing possible complications associated with pregnancy and birth of babies with abnormal birth length. Objective: The aim was to identify easily accessible parental determinants of baby's birth length in Lagos, Nigeria, using a sample of patients attending a government hospital. Methods: Parental anthropometrics and other data were obtained from 250 couples by actual measurements, oral interviews and questionnaires. Baby's birth length was measured immediately after delivery by qualified, a well-trained obstetric nurse, and association between parental and offspring parameters were assessed. Results: Weight gain, maternal weight, parity and mid-parental height were the significant parental explanatory variables of offspring birth length. They were the most suitable variables for a generated model for predicting babies' birth length from parental variables in the study. Conclusion: A model that might be useful for predicting babies' birth length from easily accessible parental variables was produced. This model may complement ultrasonographic data for predicting baby's birth length with a view to achieving better perinatal and postnatal care.


Assuntos
Antropometria , Peso ao Nascer/fisiologia , Composição Corporal/fisiologia , Adolescente , Adulto , Estatura , Índice de Massa Corporal , Peso Corporal , Feminino , Humanos , Recém-Nascido , Idade Materna , Modelos Teóricos , Nigéria , Pais , Paridade , Gravidez , Inquéritos e Questionários
8.
Lancet Child Adolesc Health ; 5(10): 719-728, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34450109

RESUMO

BACKGROUND: Intrauterine and postnatal weight are widely regarded as biomarkers of fetal and neonatal wellbeing, but optimal weight gain following preterm birth is unknown. We aimed to describe changes over time in birthweight and postnatal weight gain in very and extremely preterm babies, in relation to major morbidity and healthy survival. METHODS: In this cohort study, we used whole-population data from the UK National Neonatal Research Database for infants below 32 weeks gestation admitted to neonatal units in England and Wales between Jan 1, 2008, and Dec 31, 2019. We used non-linear Gaussian process to estimate monthly trends, and Bayesian multilevel regression to estimate unadjusted and adjusted coefficients. We evaluated birthweight; weight change from birth to 14 days; weight at 36 weeks postmenstrual age; associated Z scores; and longitudinal weights for babies surviving to 36 weeks postmenstrual age with and without major morbidities. We adjusted birthweight for antenatal, perinatal, and demographic variables. We additionally adjusted change in weight at 14 days and weight at 36 weeks postmenstrual age, and their Z scores, for postnatal variables. FINDINGS: The cohort comprised 90 817 infants. Over the 12-year period, mean differences adjusted for antenatal, perinatal, demographic, and postnatal variables were 0 g (95% compatibility interval -7 to 7) for birthweight (-0·01 [-0·05 to 0·03] for change in associated Z score); 39 g (26 to 51) for change in weight from birth to 14 days (0·14 [0·08 to 0·19] for change in associated Z score); and 105 g (81 to 128) for weight at 36 weeks postmenstrual age (0·27 [0·21 to 0·33] for change in associated Z score). Greater weight at 36 weeks postmenstrual age was robust to additional adjustment for enteral nutritional intake. In babies surviving without major morbidity, weight velocity in all gestational age groups stabilised at around 34 weeks postmenstrual age at 16-25 g per day along parallel percentile lines. INTERPRETATION: The birthweight of very and extremely preterm babies has remained stable over 12 years. Early postnatal weight loss has decreased, and subsequent weight gain has increased, but weight at 36 weeks postmenstrual age is consistently below birth percentile. In babies without major morbidity, weight velocity follows a consistent trajectory, offering opportunity to construct novel preterm growth curves despite lack of knowledge of optimal postnatal weight gain. FUNDING: UK Medical Research Council.


Assuntos
Peso ao Nascer/fisiologia , Lactente Extremamente Prematuro/crescimento & desenvolvimento , Ganho de Peso , Bases de Dados Factuais , Inglaterra , Feminino , Idade Gestacional , Humanos , Lactente , Recém-Nascido de Peso Extremamente Baixo ao Nascer/crescimento & desenvolvimento , Recém-Nascido , Estudos Longitudinais , Masculino , País de Gales
9.
J Physiol Anthropol ; 40(1): 10, 2021 Aug 27.
Artigo em Inglês | MEDLINE | ID: mdl-34452643

RESUMO

BACKGROUND: Rapid weight gain in early life is associated with adiposity later in life. However, there is limited information on the association between weight gain and body fat mass measured using precise methods. This study aimed to investigate whether weight gain is associated with body fat mass measured by dual-energy X-ray absorptiometry (DXA) in adolescents. METHODS: Participants of this retrospective cohort study were 423 adolescents born at full-term who were enrolled in the Japan Kids Body-composition Study. Anthropometric measurements related to pregnancy, delivery, and child health were obtained from the Japanese Maternal and Child Health Handbook. Fat mass in adolescents was measured with a DXA scanner. Weight gain was defined as the change in body weight from birth to age 1.5 years. Associations between birthweight and fat mass, and between weight gain and fat mass, were evaluated using multiple regression analysis. RESULTS: There was a significant positive association between weight gain from birth to age 1.5 years and fat mass in adolescents (boys: standardized regression coefficient (ß) = 0.253, p < 0.01; girls: ß = 0.246, p < 0.01), but not between birthweight standardized for gestational age and fat mass. CONCLUSION: Children with a greater change in weight from birth to age 1.5 years tended to have increased fat mass in adolescence. Weight gain in early life has a greater impact on fat mass in adolescents than birthweight.


Assuntos
Composição Corporal/fisiologia , Ganho de Peso/fisiologia , Absorciometria de Fóton , Adolescente , Adulto , Peso ao Nascer/fisiologia , Criança , Feminino , Humanos , Lactente , Recém-Nascido , Japão , Masculino , Gravidez , Estudos Retrospectivos
10.
Am J Physiol Renal Physiol ; 321(3): F322-F334, 2021 09 01.
Artigo em Inglês | MEDLINE | ID: mdl-34308670

RESUMO

Low birth weight is a risk factor for chronic kidney disease, whereas adult podocyte depletion is a key event in the pathogenesis of glomerulosclerosis. However, whether low birth weight due to poor maternal nutrition is associated with low podocyte endowment and glomerulosclerosis in later life is not known. Female Sprague-Dawley rats were fed a normal-protein diet (NPD; 20%) or low-protein diet (LPD; 8%), to induce low birth weight, from 3 wk before mating until postnatal day 21 (PN21), when kidneys from some male offspring were taken for quantitation of podocyte number and density in whole glomeruli using immunolabeling, tissue clearing, and confocal microscopy. The remaining offspring were fed a normal- or high-fat diet until 6 mo to induce catch-up growth and excessive weight gain, respectively. At PN21, podocyte number per glomerulus was 15% lower in low birth weight (LPD) than normal birth weight (NPD) offspring, with this deficit greater in outer glomeruli. Surprisingly, podocyte number in LPD offspring increased in outer glomeruli between PN21 and 6 mo, although an overall 9% podocyte deficit persisted. Postnatal fat feeding to LPD offspring did not alter podometric indexes or result in glomerular pathology at 6 mo, whereas fat feeding in NPD offspring was associated with far greater body and fat mass as well as podocyte loss, reduced podocyte density, albuminuria, and glomerulosclerosis. This is the first report that maternal diet can influence podocyte endowment. Our findings provide new insights into the impact of low birth weight, podocyte endowment, and postnatal weight on podometrics and kidney health in adulthood.NEW & NOTEWORTHY The present study shows, for the first time, that low birth weight as a result of maternal nutrition is associated with low podocyte endowment. However, a mild podocyte deficit at birth did not result in glomerular pathology in adulthood. In contrast, postnatal podocyte loss in combination with excessive body weight led to albuminuria and glomerulosclerosis. Taken together, these findings provide new insights into the associations between birth weight, podocyte indexes, postnatal weight, and glomerular pathology.


Assuntos
Tamanho Corporal/fisiologia , Nefropatias/patologia , Podócitos/patologia , Efeitos Tardios da Exposição Pré-Natal/patologia , Animais , Peso ao Nascer/fisiologia , Feminino , Rim/patologia , Glomérulos Renais/patologia , Gravidez , Ratos Sprague-Dawley
11.
Sci Rep ; 11(1): 15132, 2021 07 23.
Artigo em Inglês | MEDLINE | ID: mdl-34302021

RESUMO

Maternal obesity in pregnancy predicts offspring psychopathology risk in childhood but it remains unclear whether maternal obesity or underweight associate with adult offspring mental disorders. We examined longitudinally whether maternal body mass index (BMI) in pregnancy predicted mental disorders in her offspring and whether the associations differed by offspring birth year among 68,571 mother-child dyads of Aberdeen Maternity and Neonatal Databank, Scotland. The offspring were born 1950-1999. Maternal BMI was measured at a mean 15.7 gestational weeks and classified into underweight, normal weight, overweight, moderate obesity and severe obesity. Mental disorders were identified from nationwide registers carrying diagnoses of all hospitalizations and deaths in Scotland in 1996-2017. We found that maternal BMI in pregnancy was associated with offspring mental disorders in a time-dependent manner: In offspring born 1950-1974, maternal underweight predicted an increased hazard of mental disorders [Hazard Ratio (HR) = 1.74; 95% Confidence Interval (CI) = 1.01-3.00)]. In offspring born 1975-1999, maternal severe obesity predicted increased hazards of any mental (HR 1.60; 95% CI 1.08-2.38) substance use (HR 1.91; 95% CI 1.03-3.57) and schizophrenia spectrum (HR 2.80; 95% CI 1.40-5.63) disorders. Our findings of time-specific associations between maternal prenatal BMI and adult offspring mental disorders may carry important public health implications by underlining possible lifelong effects of maternal BMI on offspring psychopathology.


Assuntos
Crianças Adultas/psicologia , Peso ao Nascer/fisiologia , Transtornos Mentais/etiologia , Transtornos Mentais/psicologia , Efeitos Tardios da Exposição Pré-Natal/etiologia , Efeitos Tardios da Exposição Pré-Natal/psicologia , Adulto , Índice de Massa Corporal , Feminino , Humanos , Estudos Longitudinais , Transtornos do Neurodesenvolvimento/etiologia , Transtornos do Neurodesenvolvimento/psicologia , Obesidade/complicações , Obesidade/fisiopatologia , Sobrepeso/complicações , Sobrepeso/fisiopatologia , Gravidez , Complicações na Gravidez/etiologia , Complicações na Gravidez/psicologia , Fatores de Risco , Escócia , Magreza/complicações
12.
Nutrients ; 13(6)2021 May 28.
Artigo em Inglês | MEDLINE | ID: mdl-34071717

RESUMO

A high-quality diet during pregnancy may have positive effects on fetal growth and nutritional status at birth, and it may modify the risk of developing chronic diseases later in life. The aim of this study was to evaluate the association between diet quality and newborn nutritional status in a group of pregnant Mexican women. As part of the ongoing Mexican prospective cohort study, OBESO, we studied 226 healthy pregnant women. We adapted the Alternated Healthy Eating Index-2010 for pregnancy (AHEI-10P). The association between maternal diet and newborn nutritional status was investigated by multiple linear regression and logistic regression models. We applied three 24-h recalls during the second half of gestation. As the AHEI-10P score improved by 5 units, the birth weight and length increased (ß = 74.8 ± 35.0 g and ß = 0.3 ± 0.4 cm, respectively, p < 0.05). Similarly, the risk of low birth weight (LBW) and small for gestational age (SGA) decreased (OR: 0.47, 95%CI: 0.27-0.82 and OR: 0.55, 95%CI: 0.36-0.85, respectively). In women without preeclampsia and/or GDM, the risk of stunting decreased as the diet quality score increased (+5 units) (OR: 0.62, 95%IC: 0.40-0.96). A high-quality diet during pregnancy was associated with a higher newborn size and a reduced risk of LBW and SGA in this group of pregnant Mexican women.


Assuntos
Peso ao Nascer/fisiologia , Dieta Saudável/métodos , Dieta Saudável/estatística & dados numéricos , Fenômenos Fisiológicos da Nutrição Materna/fisiologia , Adolescente , Adulto , Estudos de Coortes , Feminino , Humanos , Recém-Nascido de Baixo Peso , Recém-Nascido , Recém-Nascido Pequeno para a Idade Gestacional , Masculino , México , Pessoa de Meia-Idade , Gravidez , Estudos Prospectivos
13.
Sci Rep ; 11(1): 11690, 2021 06 03.
Artigo em Inglês | MEDLINE | ID: mdl-34083688

RESUMO

Literature supports an association between transfusions and gut injury in preterm infants. We hypothesized that packed red blood (PRBC) transfusions are associated with kidney inflammation marked by a rise in urinary levels of Kidney Injury Molecule 1 (KIM-1). Prospectively, KIM-1 levels were measured before and then at 6, 12 and 24 h after a PRBC transfusion. Results are presented as mean (± SD) and median (IQR). Thirty-four infants, birth weight 865 (± 375) g, had higher pretransfusion KIM-1 levels of 2270 (830, 3250) pg/mg than what is normal for age. These were not associated with hematocrit levels. KIM-1 levels peaked between 6 and 12 h after the transfusion. Levels peaked to 3300 (1990, 6830) pg/mg; levels returned to pretransfusion levels of 2240 (1240, 3870) pg/mg by 24 h, p < 0.01. The 24-h post-transfusion KIM-1 levels were similar to pretransfusion levels, p = 0.63. PRBC transfusions in preterm infants are associated with an elevation in urinary KIM-1 levels. The mechanism of this association may be important in studying transfusion associated organ injury. KIM-1, as an inflammatory marker, may be helpful in assessing the effect of different transfusion volumes or in evaluating operational thresholds of anemia in premature infants.


Assuntos
Receptor Celular 1 do Vírus da Hepatite A/metabolismo , Anemia/terapia , Anemia/urina , Peso ao Nascer/fisiologia , Transfusão de Sangue/métodos , Feminino , Humanos , Lactente , Recém-Nascido de Baixo Peso , Recém-Nascido , Recém-Nascido Prematuro , Masculino , Estudos Prospectivos
15.
Anim Sci J ; 92(1): e13563, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-34013649

RESUMO

This prospective study was designed to investigate the effects of maternal temperament on uterine blood flow, fetal heart rate, gestational length, and fetal birth weight in a goat experimental model. Based on the arena test, behavioral testing related to fear-eliciting stimulus, goats were divided into nervous (n = 13) and calm (n = 11) groups. After mating, the perfusion of maternal uterine arteries (UTAs) and its related Doppler parameters, blood flow volume (BFV), time-averaged mean velocity (TAMEANV), acceleration (Acce), and resistance impedance (S/D), were evaluated biweekly from week two until the end of pregnancy. Fetal heart rate (FHR) was investigated during the pregnancy in addition to the gestation length (GL) and fetal birth weight (FBW). The UTA-BFV and TAMEANV, as well as Acce and S/D, were influenced by maternal temperament (p < .05). The FHR showed no significant changes between experimental animals of different temperaments (p = .81). Both GL and FBW were increased in calm rather than nervous goats (p < .05). These results indicated that the maternal nervous (temperament) have negative impacts on uterine artery Doppler indices, fetal growth, and gestational length in a goat experimental model.


Assuntos
Peso ao Nascer/fisiologia , Estatura , Desenvolvimento Fetal/fisiologia , Feto/embriologia , Feto/fisiologia , Cabras/fisiologia , Cabras/psicologia , Frequência Cardíaca Fetal , Fluxo Sanguíneo Regional , Temperamento/fisiologia , Útero/irrigação sanguínea , Animais , Feminino , Humanos , Gravidez , Estudos Prospectivos
16.
BMC Pregnancy Childbirth ; 21(1): 295, 2021 Apr 12.
Artigo em Inglês | MEDLINE | ID: mdl-33845773

RESUMO

BACKGROUND: The adequate maternal sleep duration required for favorable obstetric outcomes is unknown. We evaluated the association between maternal sleep duration and low birth weight infants, small for gestational age infants, and macrosomia. METHODS: Participants enrolled in the Japan Environment and Children's Study, a nationwide birth cohort study, with singleton pregnancies after 22 weeks, who gave birth between 2011 and 2014 were enrolled and categorized into five groups according to maternal sleep duration during pregnancy: < 6.0 h, 6.0-7.9 h, 8.0-8.9 h, 9.0-9.9 h, and 10.0-12.0 h. We evaluated the association between maternal sleep duration and the incidence of low birth weight infants (< 2500 g), very low birth weight infants (< 1500 g), small for gestational age infants, and macrosomia (> 4000 g), with women with maternal sleep duration of 6.0-7.9 h as the reference, using a multiple logistic regression model. RESULTS: In total, 82,171 participants were analyzed. The adjusted odds ratios (95% confidence intervals) for low birth weight infants in women with maternal sleep duration of 9.0-9.9 h and 10.0-12.0 h and for small for gestational age infants in women with maternal sleep duration of 9.0-9.9 h were 0.90 (0.83-0.99), 0.86 (0.76-0.99), and 0.91 (0.82-0.99), respectively, before adjusting for excessive gestational weight gain. No significant association was observed between maternal sleep duration and these outcomes after adjusting for excessive gestational weight gain. Among women with appropriate gestational weight gain, the adjusted odds ratios (95% confidence intervals) for low birth weight infants and for small for gestational age infants with sleep duration of 9.0-9.9 h were 0.88 (0.80-0.97) and 0.87 (0.78-0.97), respectively. CONCLUSIONS: Maternal sleep duration of 9.0-9.9 h was significantly associated with the decreased incidence of low birth weight infants and small for gestational age infants in pregnant women with appropriate gestational weight gain, compared with that of 6.0-7.9 h. Care providers should provide proper counseling regarding the association between maternal sleep duration and neonatal birth weight and suggest comprehensive maternal lifestyle modifications to prevent low birth weight and small for gestational age infants.


Assuntos
Peso ao Nascer/fisiologia , Macrossomia Fetal/epidemiologia , Recém-Nascido Pequeno para a Idade Gestacional , Recém-Nascido de muito Baixo Peso , Sono/fisiologia , Adulto , Feminino , Macrossomia Fetal/fisiopatologia , Humanos , Incidência , Recém-Nascido , Japão/epidemiologia , Saúde Materna/estatística & dados numéricos , Gravidez , Estudos Prospectivos , Fatores de Tempo , Adulto Jovem
17.
BMC Pregnancy Childbirth ; 21(1): 337, 2021 Apr 27.
Artigo em Inglês | MEDLINE | ID: mdl-33906616

RESUMO

BACKGROUND: Birthweight has been declining consistently for more than 30 years in Japan. This rapid rise in low birthweight is one of the worst among the countries of the Organization for Economic Co-operation and Development. We examined potential determinants of birthweight decline in Japan. METHODS: We used population-based birth certificate data from vital statistics records and retrieved 40,968,266 birth certificates of neonates born between 1980 and 2004. We analyzed time trends using linear regression analysis in examining whether the decline in birthweight could be explained by obstetrical variables such as gestational age and multiple gestations. RESULTS: From 1980 to 2004, we observed a decline in mean birthweight with a yearly effect of - 8.07 g, which became steeper after 1985, persisted until 1999, and plateaued thereafter. After adjusting for gestational age, gender, birth order, multiple gestations, and fathers' age, the yearly effect between 1980 and 2004 persisted at - 5.13 g. CONCLUSION: Recent decreases in birthweight among Japanese neonates were not fully explained by trends in gestational age, gender, birth order, multiple gestations, and fathers' age. Thus, additional factors such as pre-pregnancy maternal body mass index (BMI) and maternal diet should be considered. Reducing the rate of induced deliveries and improving the BMI or diet of young women should be a public health priority.


Assuntos
Peso ao Nascer/fisiologia , Índice de Massa Corporal , Dieta , Feminino , Previsões , Idade Gestacional , Humanos , Recém-Nascido , Japão , Modelos Lineares , Masculino , Gravidez , Gravidez Múltipla , Fatores de Risco , Fatores Sexuais
18.
Ren Fail ; 43(1): 664-675, 2021 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-33896360

RESUMO

INTRODUCTION: Worldwide, there is a global progressive rise of chronic kidney disease. In parallel, children born after intra-uterine growth retardation are surviving to adult-life and beyond. This study describes the association of birthweight with and estimated glomerular filtration rate (eGFR). METHODS: Australian Diabetes, Obesity and Lifestyle (AusDiab) study participants were asked to complete a birthweight questionnaire. The associations between birthweight and eGFR were determined. RESULTS: A total of 4502 reported information related to their birthweight, with the other responders did not provide a value. The birthweight of the participants ranged from 0.4 to 7.0 kg with a mean-(SD) of 3.37 (0.7) kg. The mean (95%CI) birthweight was lower for females, 3.28 (0.6) kg, when compared to males, 3.5 (0.7) kg. Eight percent had a birthweight less than 2.5 kg. The eGFR was strongly and positively associated with birthweight, with people in the lowest sex-specific birthweight-quintiles having the lowest mean eGFR. This relationship persisted with adjustment for confounding factors. The OR(CI) for eGFR <10th-percentile (<61.4 ml/min for females and <73.4 for males) for people in the lowest vs. the higher birthweight-quintile was 2.19 (95%CI 1.14-4.2) for females and 2.37 (1.1-5.3) for males, after adjustment for other factors. CONCLUSIONS: Birthweight had a positive relationship with eGFR. Possible explanations include an association of birthweight with nephron-endowment. From a global health perspective but more in developing countries and in populations in epidemiologic transition, where substantially lower birthweights coexist with recently improved infant and adult survivals, the overall impact of this phenomenon on the population health profile could be more substantial.


Assuntos
Albuminúria/epidemiologia , Peso ao Nascer/fisiologia , Retardo do Crescimento Fetal/epidemiologia , Taxa de Filtração Glomerular/fisiologia , Insuficiência Renal Crônica/epidemiologia , Albuminúria/diagnóstico , Austrália/epidemiologia , Estudos Transversais , Feminino , Humanos , Recém-Nascido de Baixo Peso , Recém-Nascido , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Gravidez , Prognóstico , Insuficiência Renal Crônica/diagnóstico , Fatores de Risco , Índice de Gravidade de Doença , Distribuição por Sexo
19.
PLoS One ; 16(4): e0247699, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33857144

RESUMO

Adverse birth outcomes related to air pollution are well documented; however, few studies have accounted for infant sex. There is also scientific evidence that the neighborhood socioeconomic profile may modify this association even after adjusting for individual socioeconomic characteristics. The objective is to analyze the association between air pollution and birth weight by infant sex and neighborhood socioeconomic index. All birth weights (2008-2011) were geocoded at census block level. Each census block was assigned a socioeconomic deprivation level, as well as daily NO2 and PM10 concentrations. We performed a multilevel model with a multiple statistical test and sensible analysis using the spline function. Our findings suggest the existence of a differential association between air pollution and BW according to both neighborhood socioeconomic level and infant sex. However, due to multiple statistical tests and controlling the false discovery rate (FDR), all significant associations became either not statistically significant or borderline. Our findings reinforce the need for additional studies to investigate the role of the neighborhood socioeconomic which could differentially modify the air pollution effect.


Assuntos
Poluição do Ar/efeitos adversos , Peso ao Nascer/efeitos dos fármacos , Poluentes Atmosféricos/análise , Poluição do Ar/análise , Peso ao Nascer/fisiologia , Censos , Exposição Ambiental/efeitos adversos , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Análise Multinível , Dióxido de Nitrogênio/análise , Paris/epidemiologia , Material Particulado/análise , Características de Residência , Fatores Sexuais , Fatores Socioeconômicos
20.
Pan Afr Med J ; 38: 94, 2021.
Artigo em Francês | MEDLINE | ID: mdl-33889260

RESUMO

Introduction: low birth weight is considered one of the most important indicators for the survivability of a newborn and for a higher risk of morbidity, perinatal mortality and infant mortality. The purpose of this study was to analyse factors associated with low birth weight at the Kingasani Hospital in Kinshasa. Methods: we conducted a retrospective case-control study. The data about the information of the parturients and their children born from 1st January to 31st December 2016 were collected from the maternity register of the Kingasani Hospital Center. In this study 458 cases (less than 2500 grams) were compared to 458 controls (2500-4000 grams). Multivariate analysis was carried out using binary logistic regression in order to identify factors associated with low birth weight. Results: in 2016, 3451 live births were registered and the rate of underweight was estimated to 13.27%. Bivariate analysis showed that parity, the term of pregnancy, pregnancy type and infant's sex were variables significantly associated with low birth weight. After adjusting for variables integrated in multivariate analysis, parity, the term of pregnancy and pregnancy type were still significantly associated with low birth weight. Conclusion: given these results, new studies of all the parameters involved in the occurrence of low birth weight are necessary in order to monitor the regular evolution of this issue and its associated factors.


Assuntos
Peso ao Nascer/fisiologia , Recém-Nascido de Baixo Peso/fisiologia , Adulto , Estudos de Casos e Controles , República Democrática do Congo/epidemiologia , Feminino , Humanos , Recém-Nascido , Masculino , Paridade , Gravidez , Estudos Retrospectivos , Fatores de Risco , Fatores Sexuais , Adulto Jovem
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