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2.
Zhonghua Wei Chang Wai Ke Za Zhi ; 23(2): 123-128, 2020 Feb 25.
Artigo em Chinês | MEDLINE | ID: mdl-32074790

RESUMO

Many breakthroughs in the field of surgical clinical researches have been achieved in China, but the overall quality is relatively limited, largely because of the insufficiency in standardization, rationality and scientificity of methodology. In consideration of the nature of surgical procedures and equipments, it is necessary to establish a set of methodological system, suitable for the high-quality clinical research in the surgical field. IDEAL collaboration has put forward a systematic methodological framework for innovation in surgical procedure and equipment. For the clinical research on surgical innovation, the IDEAL framework can be divided into five sequential stages, namely, Idea, Development, Exploration, Assessment and Long-term follow-up. In different stages, the difficulties to be faced, the problems to be solved, and the research design to be adopted are diverse and progressive. Although the IDEAL framework is not perfect, it is currently the best framework for surgical clinical research. While performing surgical clinical research, we should continue to think about how to improve the surgical clinical research methodology.


Assuntos
Pesquisa Biomédica/normas , Cirurgia Geral , Projetos de Pesquisa , China
5.
J Trauma Acute Care Surg ; 88(2): 320-329, 2020 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-31688786

RESUMO

BACKGROUND: There has been an unprecedented increase in critical care research recently, and there is a need for an organized and systematic approach to surgical critical care research planning. The purpose of this article was to establish a surgical critical care research agenda via a systematic review of the literature and needs assessment. METHODS: A systematic review of the literature was performed to identify high-impact critical care articles since 1999 on the basis of citation data. Using a standardized data abstraction tool, surgical representation in the literature was analyzed. A needs assessment was performed using a modified Delphi approach in three rounds to obtain consensus among members of the Critical Care Committee of the American Association for the Surgery of Trauma (n = 30) regarding research priorities in surgical critical care. RESULTS: Of 1,019 articles screened, 645 underwent full-text review, and 276 articles were included in the final analysis. Surgical patients were identified in 177 studies (64.1%), whereas trauma patients were identified in 82 (31.7%). Key categories identified during the first round of the Delphi included end of life care, traumatic brain injury (TBI), delirium, post-intensive care syndrome (PICS), hemodynamic monitoring, and volume/fluid balance. During the second and third rounds, 10 topics were classified as high priority. The three highest ranked topics were: addressing goals of care in the acute care setting (4.44 ± 0.70); improving prognostic indicators in patients with severe TBI (4.38 ± 0.85); and interventions to mitigate PICS (4.22 ± 0.65). There was a strong positive correlation in ratings (Rs value = 0.90, p = 0.001) between rounds 2 and 3. CONCLUSION: The results of this study highlight the recent surgical critical care research literature and may serve as a platform for future research endeavors in surgical critical care.


Assuntos
Pesquisa Biomédica/métodos , Cuidados Críticos/métodos , Ferimentos e Lesões/cirurgia , Pesquisa Biomédica/normas , Cuidados Críticos/normas , Cirurgia Geral/métodos , Cirurgia Geral/normas , Humanos , Guias de Prática Clínica como Assunto , Lacunas da Prática Profissional , Projetos de Pesquisa/normas , Sociedades Médicas/normas
6.
Einstein (Sao Paulo) ; 18: eAO5043, 2020.
Artigo em Inglês, Português | MEDLINE | ID: mdl-31859786

RESUMO

OBJECTIVE: To analyze the technical-scientific production of research productivity fellows of the National Council for Scientific and Technological Development, in Pediatrics, from 2013 to 2016. METHODS: First, data were obtained identifying fellowship researchers using the Lattes Platform, and subsequently calculating the indicators present in their Lattes curricula using scriptLattes software v8.10. RESULTS: In the period studied, 17 fellowship researchers were identified. They published a total of 524 articles in journals, most of them ranked as high and intermediate Qualis. In addition, fellowship researchers conducted 158 supervisions during the period, published 119 books or chapters and 465 papers in conference proceedings. CONCLUSION: The Brazilian scientific production in Pediatrics has shown to be significant and of good impact, both nationally and internationally. However, the distribution of research groups is concentrated in specific regions of Brazil.


Assuntos
Bibliometria , Bolsas de Estudo/estatística & dados numéricos , Pediatria/estatística & dados numéricos , Publicações Periódicas como Assunto/estatística & dados numéricos , Publicações/estatística & dados numéricos , Pesquisadores/estatística & dados numéricos , Pesquisa Biomédica/normas , Pesquisa Biomédica/estatística & dados numéricos , Brasil , Escolaridade , Bolsas de Estudo/normas , Humanos , Publicações Periódicas como Assunto/normas , Publicações/normas , Apoio à Pesquisa como Assunto/normas , Apoio à Pesquisa como Assunto/estatística & dados numéricos , Estudos Retrospectivos , Fatores de Tempo
7.
J Ethnopharmacol ; 246: 112230, 2020 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-31526860

RESUMO

BACKGROUND: The pharmacology, toxicology and pharmacokinetics of bioactive preparations derived from natural sources has become a flourishing field of research. However, researching complex extracts and natural products faces numerous challenges. More broadly in recent years the critique of pharmacological research, and specifically its design, the methods used and reporting has intensified. AIMS: This consensus document provides a perspective on what constitutes best practice in pharmacological research on bioactive preparations derived from natural sources, providing a perspective of what the leading specialist journals in the field consider as the core characteristics of good research. APPROACH ('METHODS'): The editors-in-chief of seven journals developed this best practice statement in an iterative process. A first draft of the guidelines (prepared by MH) was then discussed and amended by the other editors. OUTCOMES: Core to this contribution is a table which provides detailed advice including simple points like a use of appropriate controls and the full taxonomic validity of the material under investigation (see also below), to the relevance of the model for the question being researched (e.g., can specific in silico or in vitro models really address the species anti-inflammatory activity?). Therefore, obviously, researchers must pay detailed attention to reporting and discussing such studies. This information must be discussed critically (as much as it is possible based on the published papers) in terms of their scientific quality and validity. While these points are obvious, as editors, we are aware that they are often not properly implemented. CONCLUSION: We call for an approach which incorporates a careful design, meticulous execution and a detailed reporting of studies focusing on the pharmacology/bioactivity of bioactive preparations. Clearly testable research questions must be developed and investigated experimentally. As the founder of pharmacology Claude Bernard put it already in 1865: '…. either the experimenter's hypothesis will be disproved or it will be proved by experiment. When experiment disproves its preconceived ideas, the experimenter must discard or modify it.'


Assuntos
Produtos Biológicos/uso terapêutico , Pesquisa Biomédica/métodos , Pesquisa Biomédica/normas , Produtos Biológicos/administração & dosagem , Humanos , Plantas Medicinais
14.
Toxicol Pathol ; 47(6): 665-783, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-31526133

RESUMO

The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative changes in rats and mice. The purpose of this publication is to provide a standardized nomenclature for classifying changes observed in the hematolymphoid organs, including the bone marrow, thymus, spleen, lymph nodes, mucosa-associated lymphoid tissues, and other lymphoid tissues (serosa-associated lymphoid clusters and tertiary lymphoid structures) with color photomicrographs illustrating examples of the lesions. Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous lesions as well as lesions induced by exposure to test materials. The nomenclature for these organs is divided into 3 terminologies: descriptive, conventional, and enhanced. Three terms are listed for each diagnosis. The rationale for this approach and guidance for its application to toxicologic pathology are described in detail below.


Assuntos
Pesquisa Biomédica/normas , Doenças da Medula Óssea/classificação , Medula Óssea , Doenças Linfáticas/classificação , Tecido Linfoide , Animais , Animais de Laboratório , Medula Óssea/anatomia & histologia , Medula Óssea/patologia , Doenças da Medula Óssea/sangue , Doenças da Medula Óssea/imunologia , Doenças da Medula Óssea/patologia , Doenças Linfáticas/sangue , Doenças Linfáticas/imunologia , Doenças Linfáticas/patologia , Tecido Linfoide/anatomia & histologia , Tecido Linfoide/patologia , Camundongos , Ratos , Terminologia como Assunto
15.
Psychiatr Pol ; 53(3): 493-494, 2019 Jun 30.
Artigo em Inglês, Polonês | MEDLINE | ID: mdl-31522192
18.
BMC Med Ethics ; 20(1): 55, 2019 08 01.
Artigo em Inglês | MEDLINE | ID: mdl-31370847

RESUMO

BACKGROUND: Rare Disease research has seen tremendous advancements over the last decades, with the development of new technologies, various global collaborative efforts and improved data sharing. To maximize the impact of and to further build on these developments, there is a need for model consent clauses for rare diseases research, in order to improve data interoperability, to meet the informational needs of participants, and to ensure proper ethical and legal use of data sources and participants' overall protection. METHODS: A global Task Force was set up to develop model consent clauses specific to rare diseases research, that are comprehensive, harmonized, readily accessible, and internationally applicable, facilitating the recruitment and consent of rare disease research participants around the world. Existing consent forms and notices of consent were analyzed and classified under different consent themes, which were used as background to develop the model consent clauses. RESULTS: The IRDiRC-GA4GH MCC Task Force met in September 2018, to discuss and design model consent clauses. Based on analyzed consent forms, they listed generic core elements and designed the following rare disease research specific core elements; Rare Disease Research Introductory Clause, Familial Participation, Audio/Visual Imaging, Collecting, storing, sharing of rare disease data, Recontact for matching, Data Linkage, Return of Results to Family Members, Incapacity/Death, and Benefits. CONCLUSION: The model consent clauses presented in this article have been drafted to highlight consent elements that bear in mind the trends in rare disease research, while providing a tool to help foster harmonization and collaborative efforts.


Assuntos
Pesquisa Biomédica/ética , Termos de Consentimento/normas , Consentimento Livre e Esclarecido/normas , Doenças Raras/terapia , Pesquisa Biomédica/métodos , Pesquisa Biomédica/normas , Termos de Consentimento/ética , Humanos , Consentimento Livre e Esclarecido/ética
20.
Recenti Prog Med ; 110(7): 317-322, 2019.
Artigo em Italiano | MEDLINE | ID: mdl-31379364

RESUMO

Health communication must be based on open and multi-dimensional dialogue involving all stakeholders: public and private institutions, health professionals, industries, associations and, above all, citizens. Currently, communication suffers many problems related to bad research (unethical research, falsification of data, conflict of interest, incomplete reporting, spin and plagiarism) and to the limits of an academic system that does rewards quantity more than quality. A turnaround is needed, based on five major changes: establishing rules that can actually be followed; improve the quality of scientific information; accept and encourage open confrontation; allow citizens to be able to express and assert their needs; transform uncertainty from limit to value. The "Liberati's principles" must be reaffirmed: an honest communication must make the results of the research accessible to those who have to make decisions that affect their health; researchers must engage in studies that promise benefits to citizens and are not just useful to one's career or industry; before opening up new research fronts it is necessary to exhaust the potential of research already started; the definition of research priorities must be a transparent and shared process; the best evidence is the most relevant for citizens and patients. These principles and all ethical issues related should be part of educational programs for all health operators and researchers.


Assuntos
Pesquisa Biomédica/ética , Comunicação em Saúde/ética , Pesquisa Biomédica/normas , Comunicação , Humanos
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