Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 117.241
Filtrar
1.
Sheng Li Xue Bao ; 71(6): 894-904, 2019 Dec 25.
Artigo em Chinês | MEDLINE | ID: mdl-31879745

RESUMO

Ion channels are a widespread class of membrane proteins that help establish and control cell membrane potential by allowing the passive diffusion of inorganic ions with high specificity through cell membrane. They are widely distributed in various cells and tissues, and their normal structure and function are of fundamental importance for all living organisms. The rapid advances in molecular cloning, protein structure analysis, patch clamp recordings and other technologies have greatly promoted the research on the biophysical and molecular properties of ion channels, and made significant progress in the study of the relationship between ion channels and pathophysiology as well. The immune system is made up of immune cells and organs that work together to protect the body and respond to infection and disease. Remarkably, recent basic and clinical research has revealed that ion channels are frequently and abundantly expressed in immune cells and have crucial roles in immune cell development and immune response. This review summarized recent progress in the roles of ion channels in immune cells, including the expression and regulation of ion channels in immune cells, the effects of ion flux mediated by ion channels on lymphocyte development, and functional roles of ion channels in both innate and adaptive immune responses. We also discussed some unresolved and insufficiently addressed issues in the current research, so as to provide an informative reference for better understanding the functional roles of ion channels in the immune system and further elucidation of their function from a physiological and pathological point of view.


Assuntos
Imunidade , Canais Iônicos , Proteínas de Membrana , Membrana Celular , Imunidade/fisiologia , Canais Iônicos/imunologia , Pesquisa/tendências
2.
Estud. pesqui. psicol. (Impr.) ; 18(4): 1087-1105, out.-dez. 2019. tab, ilus
Artigo em Português | LILACS, Index Psicologia - Periódicos técnico-científicos | ID: biblio-994974

RESUMO

Discorre-se sobre o desenvolvimento brasileiro da psicologia do trabalho e das organizações, com o foco na sua formação pós-graduada e produção científica. Inicia-se pela demarcação conceitual. Na seção subsequente, argumenta-se a favor da relação entre o crescimento e a diversificação da subárea e também a expansão da pós-graduação no Brasil. Segue um panorama das revisões de literatura nacionais, visando ressaltar a diversidade na prática de pesquisa. Finaliza-se com considerações sobre os desafios para alcançar níveis mais elevados de amadurecimento científico.(AU)


This article aims to describe the Brazilian development of work and organizational psychology, with a focus on its graduate training and scientific production. It begins by defining concepts. The following section argues in favor of the relationship between growth and diversification of the subarea and the expansion of graduate programs in Brazil. An overview of the national scientific reviews follows, in order to mark the diversity in research practices. Finally, the chapter discusses challenges to achieve higher levels of scientific maturity.(AU)


Se aborda el desarrollo brasileño de la psicología del trabajo y de las organizaciones, con el foco en su formación en el posgrado y producción científica. Se inicia por la demarcación conceptual. En la sección posterior, se argumenta a favor de la relación entre el crecimiento y la diversificación del sub-área y también la expansión del posgrado en el Brasil. Se propone un panorama de las revisiones de literatura nacionales, con vistas a resaltar la diversidad en la práctica de investigación. Se concluye con consideraciones sobre los desafíos para alcanzar niveles más elevados de madurez científica.(AU)


Assuntos
Psicologia , Educação de Pós-Graduação , Psicologia Aplicada , Pesquisa , Pesquisa Científica e Desenvolvimento Tecnológico , Métodos
3.
Estud. pesqui. psicol. (Impr.) ; 18(4): 1137-1154, out.-dez. 2019.
Artigo em Português | LILACS, Index Psicologia - Periódicos técnico-científicos | ID: biblio-994979

RESUMO

Apresenta-se um panorama da Neuropsicologia brasileira, enfocando sua inserção no país, caracterizando o momento atual e desafios à sua consolidação. Aborda-se a trajetória da Neuropsicologia, traçando-se cinco períodos que a caracterizam, bem como sua trajetória nacional. A Neuropsicologia brasileira assiste à sofisticação da neuroimagem e ao avanço da pesquisa e interesse na área, à criação de entidades representativas, ao crescente número de publicações, grupos de pesquisa e de cursos de pós-graduação, ao desenvolvimento de instrumentos brasileiros e à ampliação da normatização e validação de instrumentos estrangeiros. Apesar desses avanços, ressalta-se a necessidade de constituir uma Neuropsicologia brasileira, sintonizada com os desafios de um país diverso, que contribua com políticas públicas, produza conhecimentos que atinjam diferentes populações e contribua para a diminuição das desigualdades sociais.(AU)


This paper aims to present an overview of Brazilian neuropsychology, focusing on the way the discipline was brought to Brazil, the present panorama of the discipline, and the challenges related to its consolidation. This article addresses the historical course of Neuropsychology, mapping the five distinct periods that characterized its history, as well as its national course. Brazilian neuropsychology is currently aided by the sophistication of neuroimaging techniques, the advancement in research and the interest in the area, as well as the creation of representative professional associations, the growing number of publications, research groups and graduate courses, the development of Brazilian instruments and the increase in standardization and validation of foreign instruments. Despite these advances, it is necessary to emphasize the need to make a Brazilian Neuropsychology, in tune with the challenges that come from a diverse country, one which contributes with public policies, produces knowledge that reaches different peoples and contributes towards reducing social inequalities.(AU)


Este artículo presenta un panorama de la Neuropsicología en Brasil, enfocándose en su inserción en el país, caracterizando el momento actual y los desafíos a su consolidación. Aborda la historia de la Neuropsicología, trazando los cinco períodos que la caracterizan y su trayectoria nacional. La Neuropsicología brasileña presencia la sofisticación de las técnicas de neuroimagen y el avance de la investigación y el interés de los estudiantes y profesionales, así como la creación de órganos representativos, el creciente número de grupos de investigación, cursos postgrado y publicaciones, el desarrollo de instrumentos brasileños de evaluación neuropsicológica y la estandarización de los procesos y validación de instrumentos extranjeros. A pesar de esos avances, se destaca la necesidad de establecer una Neuropsicología brasileña, en sintonía con desafíos y urgencias de un país diverso, que contribuya con políticas públicas, produzca y ponga en práctica conocimientos que alcancen diferentes poblaciones y contribuya con la reducción de las desigualdades sociales.(AU)


Assuntos
Humanos , Psicologia Aplicada , Neuropsicologia , Pesquisa , Brasil , Neuroimagem/psicologia , História
4.
BMJ ; 367: l6692, 2019 12 16.
Artigo em Inglês | MEDLINE | ID: mdl-31843943
5.
Rev. latinoam. cienc. soc. niñez juv ; 17(2): 58-81, jul.-dic. 2019. tab
Artigo em Português | LILACS | ID: biblio-1043043

RESUMO

Resumo (analítico) O presente texto é parte integrante dos resultados de uma pesquisa em Educação que se propõe a refletir tanto sobre as representações de professores e gestores de uma escola que se autointitula Escola Pesquisadora como também sobre a relação entre suas práticas e a construção de conhecimento de seus alunos. Os procedimentos metodológicos empreendidos foram: entrevistas semiestruturadas com 5 gestores, 8 professores e 10 alunos egressos, bem como análises documentais e observação participante. A perspectiva teórica que se buscou seguir foi a antropologia dialética, a partir da obra de Henri Lefebvre, para quem as representações se formam entre o vivido e o concebido de sujeitos determinados. O desdobramento das ações dessa escola inovadora proporcionou aos professores a ocupação de um lugar diferenciado: o de sujeitos de criação. Palabras-chave: Pesquisa de escolas eficazes, envolvimento escolar, pesquisas escolares. Eric-Educational Resources Information Center Thesaurus.


Abstract (analytical) This text is a part of the results of a research on Education aimed at reflecting not only on the representations of teachers and managers of a school which calls itself a Research School, but also on the relationship between its practices and the construction of its students' knowledge. The methodological pressures carried out were: semi-structured interviews with 5 managers, 8 teachers and 10 former students, as well as documentary analyses and participant observation. The theoretical perspective that we sought to follow was dialectical anthropology, based on the works of Henri Lefebvre, to whom the representations are formed between what is lived and what is conceived by certain individuals. The unfolding of this innovative school's actions provided the teachers with the opportunity to fill in a unique gap -the one of the subjects of creation. Keywords: Effective schools research, school involvement, school surveys. Eric-Educational Resources Information Center Thesaurus.


Resumen (analítico) El texto es parte de los resultados de una investigación en Educación que se propone reflejar sobre las representaciones de profesores y gestores de una escuela que se llama a sí mismo Escuela Investigadora, así como sobre la relación entre sus prácticas y la construcción de conocimiento de sus alumnos. Los procedimientos metodológicos emprendidos fueron: entrevistas semiestructuradas con 5 gestores, 8 profesores y 10 alumnos egresados, análisis documentales y observación participante. La perspectiva teórica que se buscó seguir fue la antropología dialéctica, a partir de la obra de Henri Lefebvre, para quien las representaciones se forman entre lo vivido y lo concebido de sujetos determinados. El desdoblamiento de las acciones de esa escuela innovadora proporcionó a los profesores la ocupación de un lugar diferenciado: el de sujetos de creación. Palabras clave: Investigaciones de escuelas eficaces, participación escolar, investigaciones escolares. Tesauro de Eric-Educational Resources Information Center.


Assuntos
Pesquisa
6.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi ; 31(5): 555-559, 2019 Jul 24.
Artigo em Chinês | MEDLINE | ID: mdl-31713395

RESUMO

Exosomes are tiny vesicles secreted by most endogenous cells, and the extracellular vesicles (EVs) are specifically secreted by cells. Recently, it was found that exosomes contain a large quantity of important substances such as proteins, nucleic acids, and lipids, which play important roles in material exchange and information transmission in cell-cell communication, and in modulating the immune response, metabolism, and expansion, metastasis, and drug resistance of tumors. This paper summarizes the recent researches on exosomes in parasites and parasitic diseases and hopes to be helpful for improving the researches of parasites and parasitic diseases.


Assuntos
Exossomos , Vesículas Extracelulares , Parasitos , Doenças Parasitárias , Animais , Vesículas Extracelulares/fisiologia , Interações Hospedeiro-Parasita/fisiologia , Parasitos/citologia , Doenças Parasitárias/parasitologia , Pesquisa/tendências
7.
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi ; 31(5): 560-564, 2019 Oct 10.
Artigo em Chinês | MEDLINE | ID: mdl-31713396

RESUMO

Hookworm infection remains a global health concern, which threatens human health. Hookworm infection is widely prevalent across the world, notably in tropical and subtropical areas. Recently, with the in-depth study of the immunity of parasitic infections, the"bidirectional effect"of host immune responses induced by helminth infections (including hookworm infections) has become increasingly prominent. On one hand, an immune response is induced in the host to kill the infected worms; on the other hand, the host produces a series of immunological changes that are conducive to the maintenance of parasite survival. The immune state of the host is regulated by various complicated mechanisms, and this may lead to the reduction in the incidence of allergic and autoimmune diseases or alleviation of the disease symptoms, which provide new insights into the management of these allergic and autoimmune diseases. The present article reviewed the advances of host immune responses induced by hook-worm infection and its potential values in the treatment of allergic asthma, inflammatory bowel disease and rheumatoid arthritis.


Assuntos
Infecções por Uncinaria , Interações Hospedeiro-Parasita , Infecções por Uncinaria/imunologia , Interações Hospedeiro-Parasita/imunologia , Humanos , Prevalência , Pesquisa/tendências
8.
Pan Afr Med J ; 33: 208, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31692729

RESUMO

The Mozambican Field Epidemiology and Laboratory Training Program (Moz-FELTP) is a two-year, competency-based post-graduate training and service program designed to build sustainable public health capacity in applied epidemiology. Despite the efforts, Moz-FELTP residents have historically difficulty to publishing their work for a variety of reasons that includes language barriers, lack of writing skills and motivation, limited budgetary support and lack of effective mentorship. This outline the need for different approaches to continuous improving the publication, such scientific writing mentorship for non-English FELTP residents.


Assuntos
Epidemiologia/educação , Linguagem , Editoração/estatística & dados numéricos , Pesquisa/educação , Educação Baseada em Competências , Humanos , Laboratórios , Mentores , Moçambique , Publicações Periódicas como Assunto/estatística & dados numéricos , Saúde Pública
9.
Pan Afr Med J ; 33: 298, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31692770

RESUMO

In Africa, training programmes as well as institutional policies on research integrity are lacking. Institutions have a responsibility to oversee research integrity through various efforts, including policies and training. We developed, implemented and evaluated an institutional approach to promote research integrity at African institutions, comprising a workshop for researchers ("bottom-up") and discussions with senior faculty on institutional policies ("top-down"). During the first day, we facilitated a workshop to introduce research integrity and promote best practices with regards to authorship, plagiarism, redundant publication and conflicts of interest. We used a variety of interactive teaching approaches to facilitate learning, including individual and group activities, small group discussions and case-based learning. We met with senior faculty on the following day to provide feedback and insights from the workshop, review current institutional policies and provide examples of what other research groups are doing. We evaluated the process. Participants actively engaged in discussions, recognised the importance of the topic and acknowledged that poor practices occurred at their institution. Discussions with senior researchers resulted in the establishment of a working group tasked with developing a publication policy for the institution. Our approach kick-started conversations on research integrity at institutions. There is a need for continued discussions, integrated training programmes and implementation of institutional policies and guidelines to promote good practices.


Assuntos
Política Organizacional , Pesquisadores/organização & administração , Pesquisa/normas , África , Autoria/normas , Humanos , Publicações/normas , Pesquisa/educação , Pesquisadores/educação
12.
Adv Exp Med Biol ; 1192: 3-15, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31705487

RESUMO

The modern society is a so-called era of big data. Whereas nearly everybody recognizes the "era of big data", no one can exactly define how big the data is a "big data". The reason for the ambiguity of the term big data mainly arises from the widespread of using that term. Along the widespread application of the digital technology in the everyday life, a large amount of data is generated every second in relation with every human behavior (i.e., measuring body movements through sensors, texts sent and received via social networking services). In addition, nonhuman data such as weather and Global Positioning System signals has been cumulated and analyzed in perspectives of big data (Kan et al. in Int J Environ Res Public Health 15(4), 2018 [1]). The big data has also influenced the medical science, which includes the field of psychiatry (Monteith et al. in Int J Bipolar Disord 3(1):21, 2015 [2]). In this chapter, we first introduce the definition of the term "big data". Then, we discuss researches which apply big data to solve problems in the clinical practice of psychiatry.


Assuntos
Big Data , Psiquiatria , Humanos , Pesquisa
13.
Adv Exp Med Biol ; 1192: 313-329, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31705502

RESUMO

With vigorous researches related to novel treatment in psychiatric field, paradigm shift is emerging with its design and assessment. Comprehension of the psychiatric phenomenon expanded beyond disease model, with dimensional approach. Assessment of patients' clinical state includes subjective reports related to problematic symptoms, functional change, and quality of life. They also include objective findings collected from mobile e-wearable monitoring system and advanced neuroimaging modalities. Novel treatment protocols are not just limited to pharmacology itself or psychotherapy itself, but the approach is integrated with stratification; pharmacological treatment enhanced by cognitive behavioral management and psychotherapeutic intervention has been emerged and studied for its impact. Numerous studies were conducted to understand placebo response and to differentiate this phenomenon with novel treatments. Trials to draw good adherence to research protocol with good compliance to treatment in real are strengthened by integrated approach, so-called psychopharmacology. With these paradigm shifts observed from recent researches, it is promising for great advance in quality of life and our mental health.


Assuntos
Psicofarmacologia , Psicoterapia , Protocolos Clínicos , Humanos , Psicotrópicos , Qualidade de Vida , Pesquisa
14.
Adv Exp Med Biol ; 1192: 453-477, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31705508

RESUMO

This chapter aims to provide a perspective of the complex formation of emotion and its operational usage in neuroscience. In the first section, the essence and function of emotion will be introduced from different perspectives. After an overview of historical and ongoing debates in the second section, the neuroscientific findings regarding emotional instances in healthy subjects and psychiatric patients will be outlined throughout the third and fourth sections. In the last section, a comprehensive approach of the newly developing field of computational psychiatry to emotion will be introduced.


Assuntos
Emoções , Neurociências , Humanos , Pesquisa
15.
Science ; 366(6465): 581-582, 2019 11 01.
Artigo em Inglês | MEDLINE | ID: mdl-31672887
16.
J Glob Health ; 9(3): 020703, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31673352

RESUMO

Background: Approximately 250 million children under the age of five in low and middle-income countries (LMICs) will not achieve their developmental potential due to poverty and stunting alone. Investments in programming to improve early childhood development (ECD) have the potential to disrupt the cycle of poverty and therefore should be prioritised. Support for ECD has increased in recent years. Nevertheless, donors and policies continue to neglect ECD, in part from lack of evidence to guide policy makers and donors about where they should focus policies and programmes. Identification and investment in research is needed to overcome these constraints and in order to achieve high quality implementation of programmes to improve ECD. Methods: The Child Health and Nutrition Research Initiative (CHNRI) priority setting methodology was applied in order to assess research priorities for improving ECD. A group of 348 global and local experts in ECD-related research were identified and invited to generate research questions. This resulted in 406 research questions which were categorised and refined by study investigators into 54 research questions across six thematic goals which were evaluated using five criteria: answerability, effectiveness, feasibility, impact, and effect on equity. Research options were ranked by their final research priority score multiplied by 100. Results: The top three research priority options from the LMIC experts came from the third thematic goal of improving the impact of interventions, whereas the top three research priority options from high-income country experts came from different goals: improving the integration of interventions, increasing the understanding of health economics and social protection strategies, and improving the impact of interventions. Conclusion: The results of this process highlight that priorities for future research should focus on the need for services and support to parents to provide nurturing care, and the training of health workers and non-specialists in implementation of interventions to improve ECD. Three of the six thematic goals of the present priority setting centred on interventions (ie, improving impact, implementation of interventions and improving the integration of interventions). In order to achieve higher coverage through sustainable interventions to improve ECD with equitable reach, interventions should be integrated and not be sector driven.


Assuntos
Desenvolvimento Infantil , Saúde Global , Pesquisa , Pré-Escolar , Humanos , Lactente , Desenvolvimento Sustentável
17.
J Surg Orthop Adv ; 28(3): 180-188, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31675294

RESUMO

As the treatment of proximal humerus fractures remains controversial in the literature, this study aims to identify highly cited articles and examine trends and characteristics. Scopus was used to identify the highest cited articles of proximal humerus fracture research. SPSS 23 was used for descriptive statistics and Pearson correlations for the relationship between citation count and density. Average citation count was 233 ± 164 with an annual citation density of 14 ± 7. Total citation count was associated with total citation density, 5-year citation count, and 5-year citation density. The Journal of Bone and Joint Surgery-American produced the most articles with 15 (30%). Thirty-five articles originated in Europe. The five most represented authors published three articles each. Finally, 13 (26%) papers appear in the American Shoulder and Elbow Surgeons Curriculum Guide. This study compiles a collection of articles investigating proximal humerus fractures for future review and demonstrates citation count to be an acceptable measure of an article's contemporary academic influence. (Journal of Surgical Orthopaedic Advances 28(3):180-188, 2019).


Assuntos
Fraturas do Úmero , Fator de Impacto de Revistas , Ortopedia , Fraturas do Ombro , Humanos , Pesquisa/tendências
18.
Adv Exp Med Biol ; 1181: 157-186, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31677143

RESUMO

Ganoderma lucidum spores (GLS) are the mature germ cells of Ganoderma lucidum. They have all the genetic substances and similar active components of Ganoderma lucidum. Similar to the fruiting body of Ganoderma lucidum, ganoderma spores powder has the effect of regulating immunity, antitumor, antioxidation, and protecting cells and so on. In recent decades, with the development of the technology of breaking the wall of Ganoderma lucidum spores and the technology of extracting and preparing, the researches and application of Ganoderma lucidum spores powder have made great progress.


Assuntos
Ganoderma , Esporos Fúngicos , Ganoderma/química , Pesquisa/tendências , Esporos Fúngicos/química
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA