Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 754
Filtrar
1.
J Cell Biol ; 220(1)2021 01 04.
Artigo em Inglês | MEDLINE | ID: mdl-33332553

RESUMO

The COVID-19 pandemic has created additional challenges for mid-career investigators seeking new academic opportunities. JCB asked scientists to share their experiences of uprooting their research careers and laboratories during the pandemic.


Assuntos
Pesquisa Biomédica/organização & administração , Pandemias , Pesquisadores/psicologia , Transportes/métodos , Adulto , Escolha da Profissão , Feminino , Humanos , Laboratórios/organização & administração , Masculino , Pesquisadores/organização & administração , /patogenicidade
8.
West J Emerg Med ; 21(5): 1114-1117, 2020 Jul 21.
Artigo em Inglês | MEDLINE | ID: mdl-32970563

RESUMO

INTRODUCTION: The coronavirus disease 2019 (COVID-19) pandemic has seriously impacted clinical research operations in academic medical centers due to social distancing measures and stay-at-home orders. The purpose of this paper is to describe the implementation of a program to continue clinical research based out of an emergency department (ED) using remote research associates (RA). METHODS: Remote RAs were trained and granted remote access to the electronic health record (EHR) by the health system's core information technology team. Upon gaining access, remote RAs used a dual-authentication process to gain access to a host-based, firewall-protected virtual network where the EHR could be accessed to continue screening and enrollment for ongoing studies. Study training for screening and enrollment was also provided to ensure study continuity. RESULTS: With constant support and guidance available to establish this EHR access pathway, the remote RAs were able to gain access relatively independently and without major technical troubleshooting. Each remote RA was granted access and trained on studies within one week and self-reported a high degree of program satisfaction, EHR access ease, and study protocol comfort through informal evaluation surveys. CONCLUSIONS: In response to the COVID-19 pandemic, we virtualized a clinical research program to continue important ED-based studies.


Assuntos
Betacoronavirus , Pesquisa Biomédica/organização & administração , Infecções por Coronavirus/prevenção & controle , Registros Eletrônicos de Saúde , Serviço Hospitalar de Emergência/organização & administração , Pandemias/prevenção & controle , Pneumonia Viral/prevenção & controle , Pesquisadores/organização & administração , Centros Médicos Acadêmicos/organização & administração , California , Humanos , Informática Médica , Desenvolvimento de Programas
13.
Nature ; 582(7810): 84-88, 2020 06.
Artigo em Inglês | MEDLINE | ID: mdl-32483374

RESUMO

Data analysis workflows in many scientific domains have become increasingly complex and flexible. Here we assess the effect of this flexibility on the results of functional magnetic resonance imaging by asking 70 independent teams to analyse the same dataset, testing the same 9 ex-ante hypotheses1. The flexibility of analytical approaches is exemplified by the fact that no two teams chose identical workflows to analyse the data. This flexibility resulted in sizeable variation in the results of hypothesis tests, even for teams whose statistical maps were highly correlated at intermediate stages of the analysis pipeline. Variation in reported results was related to several aspects of analysis methodology. Notably, a meta-analytical approach that aggregated information across teams yielded a significant consensus in activated regions. Furthermore, prediction markets of researchers in the field revealed an overestimation of the likelihood of significant findings, even by researchers with direct knowledge of the dataset2-5. Our findings show that analytical flexibility can have substantial effects on scientific conclusions, and identify factors that may be related to variability in the analysis of functional magnetic resonance imaging. The results emphasize the importance of validating and sharing complex analysis workflows, and demonstrate the need for performing and reporting multiple analyses of the same data. Potential approaches that could be used to mitigate issues related to analytical variability are discussed.


Assuntos
Análise de Dados , Ciência de Dados/métodos , Ciência de Dados/normas , Conjuntos de Dados como Assunto , Neuroimagem Funcional , Imagem por Ressonância Magnética , Pesquisadores/organização & administração , Encéfalo/diagnóstico por imagem , Encéfalo/fisiologia , Conjuntos de Dados como Assunto/estatística & dados numéricos , Feminino , Humanos , Modelos Logísticos , Masculino , Metanálise como Assunto , Modelos Neurológicos , Reprodutibilidade dos Testes , Pesquisadores/normas , Software
15.
Cytometry A ; 97(9): 882-886, 2020 09.
Artigo em Inglês | MEDLINE | ID: mdl-32583531

RESUMO

Operating shared resource laboratories (SRLs) in times of pandemic is a challenge for research institutions. In a multiuser, high-turnover working space, the transmission of infectious agents is difficult to control. To address this challenge, imaging core facility managers being members of German BioImaging discussed how shared microscopes could be operated with minimal risk of spreading SARS-CoV-2 between users and staff. Here, we describe the resulting guidelines and explain their rationale, with a focus on separating users in space and time, protective face masks, and keeping surfaces virus-free. These recommendations may prove useful for other types of SRLs. © 2020 The Authors. Cytometry Part A published by Wiley Periodicals LLC. on behalf of International Society for Advancement of Cytometry.


Assuntos
Betacoronavirus/patogenicidade , Pesquisa Biomédica/organização & administração , Infecções por Coronavirus/prevenção & controle , Controle de Infecções , Laboratórios/organização & administração , Microscopia , Saúde do Trabalhador , Pandemias/prevenção & controle , Pneumonia Viral/prevenção & controle , Comportamento Cooperativo , Infecções por Coronavirus/transmissão , Infecções por Coronavirus/virologia , Descontaminação , Contaminação de Equipamentos/prevenção & controle , Alemanha , Humanos , Exposição Ocupacional/prevenção & controle , Equipamento de Proteção Individual , Pneumonia Viral/transmissão , Pneumonia Viral/virologia , Fatores de Proteção , Pesquisadores/organização & administração , Medição de Risco , Fatores de Risco , Distância Social , Fluxo de Trabalho
20.
J Clin Nurs ; 29(15-16): 3054-3063, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32441860

RESUMO

AIM: To explore the understanding and experiences of research nurses who obtain informed consent from adult patients participating in emergency care research. DESIGN: Qualitative phenomenographic descriptive study. METHODS: Ten research nurses from six hospitals in England were recruited. Data were collected using semi-structured face-to-face and telephone interviews between January 2019 and March 2019. Interviews were transcribed verbatim and analysed thematically, informed by phenomenography. COREQ was followed. RESULTS: Three main themes were identified: (a) emergency research is different, (b) protecting the patient, and (c) experience and confidence with recruitment. It was found that obtaining patient consent in emergency care research was challenging and timing of the process was crucial. Nurses with more experience of emergency care were more confident in approaching patients and their families. There was variability in out-of-hours recruitment which was a consequence of the range of informed consent processes used and the different levels of engagement of clinical teams. CONCLUSION: There is a variety of organisational cultures, processes and procedures which affect the way consent is obtained in emergency care research. A team approach was evident in the hospitals where consent rates were high and was more successful than those reliant solely on the presence of a research nurse. Organisations were able to recruit successfully to emergency care research studies irrespective of size and configuration. Further investigation of their models of working and strategies for engagement is needed. Experienced research nurses made a positive difference to recruitment and were more likely to approach patients to obtain consent. RELEVANCE TO CLINICAL PRACTICE: The understanding and experiences of recruitment to clinical trials in emergency care research by research nurses can help identify barriers to recruitment. This study provides useful insights for healthcare practitioners, clinical trials coordinators and sponsors about how best to develop protocols and policies to increase recruitment to emergency care research.


Assuntos
Consentimento Livre e Esclarecido , Pesquisa em Enfermagem/métodos , Seleção de Pacientes , Pesquisadores/organização & administração , Adulto , Ensaios Clínicos como Assunto , Serviço Hospitalar de Emergência/organização & administração , Inglaterra , Feminino , Humanos , Pesquisa Qualitativa
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA