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1.
Medicine (Baltimore) ; 98(28): e16354, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31305427

RESUMO

RATIONALE: Cryptococcosis is a significant life-threatening fungal infection in worldwide, mainly reported in immunocompromised patients. Pleural effusion presentation of cryptococcal infection as the only clinical presentation is rarely seen in pulmonary cryptococcosis, which may lead to be misdiagnosed, and the study on this subject will provide further insights. PATIENT CONCERNS: A 64-year-old man was hospitalized in our department and diagnosed as hepatic B cirrhosis. A computed tomography (CT) of the thorax showed a massive right pleural effusion without pulmonary parenchymal abnormalities. He was started on empirical treatment for pleural tuberculosis (TB). However, during his hospitalization, a right pleural effusion developed and fever was not controlled. DIAGNOSES: On day 14 admission, pleural fluid cultured positive for Cryptococcus neoformans. The C neoformans isolate belonged to ST5 and molecular type VNI (var. grubii). INTERVENTIONS: The patient was diagnosed with cryptococcal pleuritis, then amphotericin B and fluconazole were administrated. OUTCOMES: Finally, the patient was improved and discharged from our hospital. LESSONS: Similar cases in cryptococcal pleuritis patients with pleural effusion as the only clinical presentation in the literature are also reviewed. Through literature review, we recommend that pleural effusion cryptococcal antigen test should be used to diagnose cryptococcal pleuritis to reduce misdiagnosis. The early administration of antifungal drug with activity to Cryptococcus seemed beneficial in preventing dissemination of cryptococcosis.


Assuntos
Criptococose/diagnóstico , Cirrose Hepática/diagnóstico , Derrame Pleural/diagnóstico , Pleurisia/diagnóstico , Criptococose/complicações , Criptococose/tratamento farmacológico , Diagnóstico Diferencial , Hepatite B/complicações , Hepatite B/diagnóstico , Humanos , Cirrose Hepática/complicações , Masculino , Pessoa de Meia-Idade , Derrame Pleural/complicações , Derrame Pleural/tratamento farmacológico , Pleurisia/complicações , Pleurisia/tratamento farmacológico
2.
J Bronchology Interv Pulmonol ; 26(2): 132-136, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30908392

RESUMO

Chronic pleural infection is characterized by thickened pleura and nonexpandable lung often requiring definitive surgical intervention, such as decortication and/or pleural obliteration procedures. Such procedures are associated with significant morbidity and require proper patient selection for a successful outcome. We report a cohort of 11 patients with pleural space infection and a nonexpandable lung treated with tunneled pleural catheters (TPCs). Following placement, hospital discharge and TPC removal occurred after a median of 5 and 36 days, respectively. Three patients presented with residual loculated effusion that resolved with instillation of intrapleural fibrinolytic therapy. One patient eventually required open window thoracostomy for ongoing pleural infection due to poor medical compliance with TPC care and drainage instructions. TPCs represent an alternative option for drainage of an infected pleural space in nonsurgical candidates with a nonexpandable lung. Their use, as a compliment to traditional treatment, may facilitate prompt hospital discharge and ambulatory management in patients with limited life expectancy.


Assuntos
Cateteres , Pleurisia/cirurgia , Toracostomia , Adulto , Idoso , Idoso de 80 Anos ou mais , Antibacterianos/uso terapêutico , Candidíase/tratamento farmacológico , Candidíase/cirurgia , Tubos Torácicos , Drenagem , Infecções por Escherichia coli/tratamento farmacológico , Infecções por Escherichia coli/cirurgia , Feminino , Fluoroscopia , Infecções por Fusobacterium/tratamento farmacológico , Infecções por Fusobacterium/cirurgia , Humanos , Masculino , Pessoa de Meia-Idade , Pleurisia/tratamento farmacológico , Estudos Retrospectivos , Infecções Estafilocócicas/tratamento farmacológico , Infecções Estafilocócicas/cirurgia , Infecções Estreptocócicas/tratamento farmacológico , Infecções Estreptocócicas/cirurgia , Cirurgia Torácica Vídeoassistida , Toracoscopia
3.
J Sci Food Agric ; 99(6): 2987-2997, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30478925

RESUMO

BACKGROUND: Curry powder is a blend of spices that is extensively consumed worldwide and mainly in Central Asia. Its preparation is strictly related to each locality and, because of the health benefits of its constituents, eight commercial forms of this condiment were biologically and chemically investigated. This study aimed to compare their chemical profile as well as their anti-inflammatory, cytotoxic, and antiparasitic activities. RESULTS: Curry samples 1 and 7 inhibited leukocyte influx and myeloperoxidase activity, while only 7 was active on protein exudate and NOx species. 2, 6, and 8 displayed trypanocidal effect against Trypanosoma cruzi amastigote, whereas 6 showed antileishmanial activity on Leishmania amazonensis amastigote. 2, 6, and 8 also inhibited the growth of THP-1 cells used as the parasite's host. Among the cytotoxic samples (4 and 6), curry sample 6 induced apoptosis in MDA-MB-231 cells. Nevertheless, 4 and 6 were unselectively cytotoxic to non-tumoral and tumoral cells. The anti-inflammatory, cytotoxicity, and antiparasitic assays were respectively performed by carrageenan-induced pleurisy test, Alamar blue assay, and intracellular parasite-host cell model. Ultra-performance liquid chromatographic-electrospray ionization mass spectrometric data from the spices revealed both similar and different metabolites in their composition. CONCLUSION: The results obtained indicate that different formulations can contribute different health benefits as a result of their chemical composition. © 2018 Society of Chemical Industry.


Assuntos
Anti-Inflamatórios/química , Anti-Inflamatórios/farmacologia , Antiprotozoários/química , Antiprotozoários/farmacologia , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Especiarias/análise , Apoptose/efeitos dos fármacos , Linhagem Celular Tumoral , Sobrevivência Celular/efeitos dos fármacos , Cromatografia Líquida de Alta Pressão , Humanos , Leishmania/efeitos dos fármacos , Leishmania/crescimento & desenvolvimento , Pleurisia/tratamento farmacológico , Pleurisia/imunologia , Pós/química , Espectrometria de Massas por Ionização por Electrospray , Trypanosoma cruzi/efeitos dos fármacos , Trypanosoma cruzi/crescimento & desenvolvimento
4.
J Ethnopharmacol ; 231: 66-72, 2019 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-30395975

RESUMO

ETHNOPHARMACOLOGICAL RELEVANCE: Alchornea glandulosa (Euphorbiaceae) has traditionally been used in medicine for treating immune-mediated inflammatory diseases. AIM OF STUDY: This work aimed to evaluate the anti-inflammatory effects of a methanolic extract of leaves from A. glandulosa (MEAG), as well as the ethyl acetate fraction (EAFAG) and isolated compound guanidine alkaloid N-1, N-2, N-3-triisopentenylguanidine (AG-1), in experimental in vivo models of inflammation in mice. We also investigated this extract's phenols, flavonoids and flavonol compounds. MATERIALS AND METHODS: MEAG (extracted by maceration with methanol), EAFAG (fraction resulting from the partition of the methanolic extract with ethyl acetate) and AG-1 (alkaloid isolated by chromatographic methods) were analysed. MEAG and EAFAG were analysed by HPLC/DAD. The effects of MEAG (30, 100 and 300 mg/kg), EAFAG (30, 100 and 300 mg/kg) and AG-1 (5 and 30 mg/kg) were studied in the following experimental mouse models: paw oedema and myeloperoxidase (MPO) activity, croton-oil-induced ear oedema, leukocyte migration in a pleurisy model induced by carrageenan and zymosan induction of joint inflammation. RESULTS: MEAG and EAFAG were analysed by LC/DAD, and phenolic acids (gallic acid and caffeic acid) and flavonoids (myricetin-3-O-α-rhamnopyranoside and quercetin) were detected. MEAG, EAFAG and AG-1 were used in the carrageenan-induced paw oedema model and showed maximum inhibitions of 60.10% (MEAG, 2 h, 300 mg/kg) and 66.21% (EAFAG, 2 h, 300 mg/kg). AG-1 at 5 mg/kg showed significant inhibition, ranging from 60.92% to 63.13%, at all evaluated times, and the 30 mg/kg dose showed inhibition of 42.12% (1 h) and 40.36% (2 h). MEAG (37%, 46.1% and 68.11%) and EAFAG (31%, 42.21% and 48.93%), at doses of 30, 100 and 300 mg/kg, respectively, significantly reduced the increase in MPO activity, and AG-1 (5 and 30 mg/kg) showed inhibition of 64.62% and 65.12%, respectively. In the pleurisy model, MEAG (300 mg/kg), EAFAG (300 mg/kg) and AG-1 (30 mg/kg) significantly reduced the migration of total leukocytes with maximal inhibition of 80.90%, 83.17% and 89.39%, respectively. In the croton oil model, pretreatment with MEAG (0.1, 0.3 and 1 mg/ear) increased the diameter of the right ear (30.32%, 48.87% and 53.09%, respectively). Finally, MEAG (100 and 300 mg/kg; 33.11% and 56.03%) and EAFAG (100 and 300 mg/kg; 36.89% and 50.53%) reduced zymosan-induced oedema formation. CONCLUSIONS: To the best of our knowledge, these results are the first to demonstrate that A. glandulosa exhibits oral and topical anti-inflammatory activity. This study detected alkaloid and phenol/polyphenolic compounds in A. glandulosa, which may help to explain the ethnobotanical use of this plant in traditional medicine in Brazil to treat immune-mediated inflammatory diseases.


Assuntos
Alcaloides/uso terapêutico , Anti-Inflamatórios/uso terapêutico , Euphorbiaceae , Guanidinas/uso terapêutico , Extratos Vegetais/uso terapêutico , Administração Oral , Administração Tópica , Animais , Artrite/induzido quimicamente , Artrite/tratamento farmacológico , Carragenina , Óleo de Cróton , Edema/induzido quimicamente , Edema/tratamento farmacológico , Feminino , Masculino , Camundongos , Fitoterapia , Folhas de Planta , Pleurisia/induzido quimicamente , Pleurisia/tratamento farmacológico , Zimosan
5.
J Ethnopharmacol ; 231: 50-56, 2019 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-30415057

RESUMO

ETHNOPHARMACOLOGICAL RELEVANCE: Mikania glomerata Spreng. (MG) and Mikania laevigata Sch. Bip. ex Baker (ML), popularly known as guaco, are medicinal plants similar in morphology, chemical composition and medicinal uses. Both species are often used and sold without distinction; however, it is believed that their chemical composition is different. AIM: Thus, the aim of this study is to investigate if the aqueous extract of MG and ML present similar anti-inflammatory activity to the point of being used interchangeably. MATERIAL AND METHODS: Different doses of both extracts and coumarin were given to rats in different experimental models to assess the anti-inflammatory activity between these two species. For this, the animals were submitted to paw edema, pleurisy and degranulation of peritoneal mast cell and the extracts were also characterized by Ultra High Efficiency Liquid Chromatography coupled to Mass Spectrometry (UHPLC-MS). RESULTS: The chromatographic method showed that ML presents ten times more coumarin than MG. Oral administration of MG, ML and coumarin inhibited paw edema induced by carrageenan (400 mg/kg, 55% inhibition; 400 mg/kg, 57% inhibition; 75 mg/kg, 38% inhibition; p < 0.05, respectively). MG, ML and coumarin treatment also inhibited the edema induced by compound 48/80 (400 mg/kg, 56% inhibition; 400 mg/kg, 69% inhibition; 75 mg/kg, 40% inhibition; p < 0.05, respectively). MG, ML and coumarin did not prevent mast cell degranulation and the consequent histamine release in Wistar rat peritoneal mast cells induced by compound 48/80. MG did not inhibit cell infiltration in pleurisy nor the highest dose tested, while ML decreased the leukocyte migration (200 and 400 mg/kg, 23% and 30% inhibition; p < 0.001, respectively) and, to a lesser extent, coumarin also reduced cell infiltration (10, 50 and 75 mg/kg; 15%, 16% and 17% inhibition; p < 0.001, respectively). CONCLUSION: The variation of the results of the anti-inflammatory activity found in M. glomerata and M. laevigata demonstrates that these two species should not be used interchangeably. Coumarin, as already proven, has anti-inflammatory action however, we have suggested that it probably is not the only component responsible for this therapeutic effect in the extracts.


Assuntos
Anti-Inflamatórios/uso terapêutico , Edema/tratamento farmacológico , Mikania , Extratos Vegetais/uso terapêutico , Pleurisia/tratamento farmacológico , Animais , Anti-Inflamatórios/química , Anti-Inflamatórios/farmacologia , Carragenina , Degranulação Celular/efeitos dos fármacos , Edema/induzido quimicamente , Edema/imunologia , Masculino , Mastócitos/efeitos dos fármacos , Mastócitos/fisiologia , Mikania/química , Compostos Fitoquímicos/análise , Compostos Fitoquímicos/farmacologia , Compostos Fitoquímicos/uso terapêutico , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Folhas de Planta/química , Pleurisia/induzido quimicamente , Pleurisia/imunologia , Ratos Wistar , p-Metoxi-N-metilfenetilamina
6.
Naunyn Schmiedebergs Arch Pharmacol ; 392(1): 55-68, 2019 01.
Artigo em Inglês | MEDLINE | ID: mdl-30215112

RESUMO

Some species of the genus Miconia are used in Brazilian folk medicine as analgesic and anti-inflammatory; however, several species of this genus are still poorly studied. Therefore, the aims of this study were to investigate the phytochemistry characterization by UPLC-DAD-QTOF-MS/MS, acute toxicity, anti-inflammatory and antinociceptive properties of Miconia minutiflora (Bonpl.) DC. The methanol extract of M. minutiflora (Mm-MeOH) was subjected to ultra-high-performance liquid chromatography (UPLC-DAD-QTOF-MS/MS) for the identification of the main phytocompounds. The anti-inflammatory properties of the extracts were studied using several inflammation models induced by carrageenan and acetic acid-induced vascular permeability. Antinociceptive effects of Mm-MeOH were assessed in nociception induced by intraperitoneal acetic acid or subplantar formalin injection. The role of α-adrenergic, cholinergic, and opioid receptors in modulating the extract's antinociceptive activity was determined. Analyses by UPLC-DAD-QTOF-MS/MS revealed the presence of ellagic acid, gallotannin, and terpenes in the methanol extract. Mm-MeOH (100 mg/kg) reduced carrageenan-induced paw edema and vascular permeability and inhibited leukocyte migration toward the air pouch and pleural cavity. Furthermore, Mm-MeOH decreased tumor necrosis factor-α (TNF-α) and interleukin-1ß (IL-1ß) levels. Administration of Mm-MeOH reduced the number of writhes by 58.9% and increased the pain threshold in the formalin test. The anti-inflammatory action mechanism of Mm-MeOH is associated with inhibition of proinflammatory cytokines TNF-α and IL-1ß, whereas the antinociceptive actions involve peripheral and central mechanisms with participation of α2-adrenergic receptors. These effects may be attributed to the presence of polyphenolics in the extract.


Assuntos
Analgésicos/uso terapêutico , Anti-Inflamatórios/uso terapêutico , Edema/tratamento farmacológico , Melastomataceae , Dor/tratamento farmacológico , Extratos Vegetais/uso terapêutico , Pleurisia/tratamento farmacológico , Ácido Acético , Analgésicos/química , Animais , Anti-Inflamatórios/química , Permeabilidade Capilar/efeitos dos fármacos , Carragenina , Cromatografia Líquida de Alta Pressão , Edema/induzido quimicamente , Formaldeído , Masculino , Dor/induzido quimicamente , Compostos Fitoquímicos/análise , Compostos Fitoquímicos/uso terapêutico , Fitoterapia , Extratos Vegetais/química , Folhas de Planta , Pleurisia/induzido quimicamente , Ratos Wistar , Espectrometria de Massas em Tandem
7.
Curr Pharm Biotechnol ; 19(12): 973-981, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30468122

RESUMO

BACKGROUND: Trichilia silvatica, popularly known as "catiguá-branco", is distributed in Brazil (Mato Grosso do Sul), and members of this genus are commonly used for the treatment of rheumatism (arthritis). The aim of this research was to investigate the anti-inflammatory, antioxidant and antiproliferative activities of the methanolic extract of the leaves (MEL-TS) and bark (MEB-TS) of T. silvatica. We also evaluated the concentration of phenolic compounds, flavonoids, flavonol, and condensed tannins by liquid chromatography - photodiode array (LC/PDA) analysis. METHODS: The MEL-TS and MEB-TS revealed the presence of caffeic acid in both extracts by LC/PDA. The samples were evaluated for antioxidant activity using free-radical scavenging and lipoperoxidation assays. The anti-inflammatory effects were studied in carrageenan-induced paw edema, pleurisy and zymosan-induced arthritis. RESULTS: The MEL-TS and MEB-TS showed the total phenolic concentration (270.8 ± 17.10 mg gallic acid equivalents GAE/g extract and 278.8 ± 25.13 mg GAE/ g extract, respectively), and flavonoids in MEL-TS (209.30 ± 2.91 mg quercetin equivalents QE/ g extract). In the lipoperoxidation assay, exhibited moderate antioxidant activity with IC50 values ≤ 35.32 µg/mL. Both extracts inhibited oedema induced by carrageenan at 2 h and 4 h, inhibited leukocyte migration at 6 h post administration, and did not impact zymosan-induced arthritis. Finally, MEL-TS was particularly effective against prostate cell line (GI50 ≤ 0.22 µg/mL). CONCLUSION: Overall, the results indicated that T. silvatica reduce migration leukocytes activity, edema formation in these models of experimental arthritis could explain the popular use for treatment of inflammatory processes (rheumatism).


Assuntos
Anti-Inflamatórios/isolamento & purificação , Antioxidantes/isolamento & purificação , Proliferação de Células/efeitos dos fármacos , Meliaceae/química , Extratos Vegetais/isolamento & purificação , Animais , Anti-Inflamatórios/farmacologia , Antioxidantes/farmacologia , Compostos de Bifenilo/química , Brasil , Linhagem Celular Tumoral , Edema/tratamento farmacológico , Feminino , Radicais Livres/química , Humanos , Masculino , Meliaceae/crescimento & desenvolvimento , Camundongos , Picratos/química , Casca de Planta/química , Extratos Vegetais/farmacologia , Folhas de Planta/química , Pleurisia/tratamento farmacológico
8.
Acta Gastroenterol Belg ; 81(3): 427-429, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30350533

RESUMO

Cytomegalovirus (CMV) reactivation is a common complication after liver transplantation. In patients with CMV infection, indicated by a positive CMV DNA titer, the presence of any clinical symptom is termed CMV disease. The most common organ affected in CMV disease is the gastrointestinal tract, causing esophagitis, gastritis, enteritis or colitis. CMV infection of the pleura and pericard has been reported in immunocompromised patients, but is rarely seen following liver transplantation.We report a case of a 59-year-old male who developed CMV pleuropericarditis after liver transplantation. Initial ganciclovir treatment did not improve the patient's symptoms and therapy was switched to Foscarnet which ultimately resulted in resolution of infection. However, a few weeks after Foscarnet cessation, the patient again developed bilateral pleural effusion. Ultimate biochemical and clinical response was achieved with IV ganciclovir treatment. The patient was discharged from the hospital with oral Valganciclovir for 3 weeks and has since remained relapse free for >1 year.


Assuntos
Infecções por Citomegalovirus/diagnóstico , Transplante de Fígado , Pericardite/diagnóstico , Pleurisia/diagnóstico , Antivirais/uso terapêutico , Infecções por Citomegalovirus/etiologia , Infecções por Citomegalovirus/terapia , Drenagem , Ganciclovir/uso terapêutico , Rejeição de Enxerto/prevenção & controle , Humanos , Imunossupressores/efeitos adversos , Cirrose Hepática Alcoólica/cirurgia , Masculino , Pessoa de Meia-Idade , Pericardiocentese , Pericardite/etiologia , Pericardite/terapia , Pleurisia/tratamento farmacológico , Pleurisia/etiologia , Toracentese , Tomografia Computadorizada por Raios X
9.
J Ethnopharmacol ; 226: 132-142, 2018 Nov 15.
Artigo em Inglês | MEDLINE | ID: mdl-30114515

RESUMO

ETHNOPHARMACOLOGICAL RELEVANCE: Some species of Campomanesia are used in the folk medicine due to anti-inflammatory, anti-diarrheal, anti-diabetes and hypercholesterolemic. However studies with Campomanesia guazumifolia (Cambess.) O. Berg. are scarce. AIM OF THE STUDY: This study investigated the anti-inflammatory activity and toxicological profile of infusion obtained from leaves of Campomanesia guazumifolia in mice. MATERIALS AND METHODS: Leaves infusion of C. guazumifolia was obtained in the proportion of 20 g/L (leaves/water) at 95-100 °C for 10 min in an enclosed container. The acute toxicity of the leaves infusion of C. guazumifolia lyophilized (ICG) was assessed by oral administration to female mice at doses of 500, 1000, 2000, and 5000 mg/kg, and the general behavior and toxic symptoms were observed for 14 days. In the subacute toxicity model, female mice were treated orally with the ICG (250, 500, and 1000 mg/kg) during 28 days, and biochemical, toxic signs and the estrous cycle were evaluated. The anti-inflammatory activity of the ICG (70, 300 and 700 mg/kg) was analyzed using carrageenan-induced pleurisy and inflammatory paw (mechanical and thermal hyperalgesia). RESULTS: Three flavonoids glycosylated and a cyclohexanecarboxylic acid were identified in the ICG: quercetin pentose, quercetin deoxyhexoside, myricetin deoxyhexoside and quinic acid. No clinical signs of acute toxicity were observed, suggesting that the LD50 (Lethal Dose) is above 5000 mg/kg. Subacute exposure of mice to the ICG did not change significantly the hematological and biochemical parameters as well as histology of organs. The ICG increased the duration of estrous cycle in all phases, showing anti-inflammatory potential by decreasing leukocyte migration, extravasation protein in the pleural cavity and antiedematogenic activity. The ICG treatment at a dose of 700 mg/kg decreased the mechanical hyperalgesia, while at doses of 300 mg/kg and 700 mg/kg, decreased the sensitivity to the cold. CONCLUSION: The results evidenced the anti-inflammatory potential with low toxicity of infusion of the leaves of C. guazumifolia, supporting the popular use of this species.


Assuntos
Anti-Inflamatórios/uso terapêutico , Edema/tratamento farmacológico , Flavonoides/uso terapêutico , Hiperalgesia/tratamento farmacológico , Myrtaceae , Extratos Vegetais/uso terapêutico , Pleurisia/tratamento farmacológico , Animais , Carragenina , Edema/induzido quimicamente , Ciclo Estral/efeitos dos fármacos , Feminino , Masculino , Camundongos , Folhas de Planta , Pleurisia/induzido quimicamente , Testes de Toxicidade Aguda , Testes de Toxicidade Subaguda
10.
Eur J Pharmacol ; 836: 83-88, 2018 Oct 05.
Artigo em Inglês | MEDLINE | ID: mdl-30118661

RESUMO

Chrysin, a natural polyphenol plentifully contained in honey, propolis, vegetables and fruits, it has been reported to exert a variety of pharmacological activities. In the present study, we mainly investigated the protective effects and underlying molecular mechanisms of chrysin on carrageenan-induced lung injury in rats. The results showed that chrysin inhibited the neutrophils infiltration, attenuated histological injury of lung tissues, decreased PMNs markers level and oxidative stress markers levels of lungs in rats. Further studies showed chrysin can inhibit the NF-кB activation in neutrophils cells, activate SIRT1/NRF2 pathway and reduce the expression of adhesion molecule in lung tissues. Taken together, these results suggested that chrysin can attenuate carrageenan-induced lung injury via inhibition of neutrophils activation and oxidative stress response, and that this attenuation is, at least partially, related to up-regulation of SIRT1/NRF2 signaling pathway. This study also validates SIRT1/NRF2 is an effective pharmacological target to protect against carrageenan-induced lung injury.


Assuntos
Carragenina/efeitos adversos , Flavonoides/farmacologia , Lesão Pulmonar/tratamento farmacológico , Fator 2 Relacionado a NF-E2/metabolismo , Pleurisia/tratamento farmacológico , Transdução de Sinais/efeitos dos fármacos , Sirtuína 1/metabolismo , Animais , Biomarcadores/metabolismo , Citocinas/metabolismo , Flavonoides/uso terapêutico , Lesão Pulmonar/induzido quimicamente , Lesão Pulmonar/metabolismo , Lesão Pulmonar/patologia , Masculino , Infiltração de Neutrófilos/efeitos dos fármacos , Estresse Oxidativo/efeitos dos fármacos , Fosforilação/efeitos dos fármacos , Pleurisia/induzido quimicamente , Pleurisia/metabolismo , Pleurisia/patologia , Ratos , Ratos Sprague-Dawley , Fator de Transcrição RelA/metabolismo
11.
Tuberk Toraks ; 66(1): 72-75, 2018 Mar.
Artigo em Turco | MEDLINE | ID: mdl-30020046

RESUMO

A 56-year-old male patient presented with history of complaints of night sweats, short ness of breath, cough and yellow sputum, fever. There was a history of tumor neurosis factor-alpha (etanercept) due to ankylosing spondylitis. Postero-anterior chest X-ray; the right sinus was blunt, the right diaphragm had linear opacity compatible with atelectasis extending from the diaphragm to the periphery, left pleural effusion, left middle basal paracardiac opacity. In thorax tomography; pleural effusion and pericardial effusion and compressive atelectasis in the adjacent lung parenchyma were detected. Lymphocyte dominance had in cytological examination. Active chronic pleuritis and fibrinous exudate as benign cytology were reported in pleural biopsy. We are thought to develop pleurisy due to anti TNF-induced lupus like syndrome. 100 mg prednol was applied for three days. One month later the control was found toregress in the filter.


Assuntos
Pleurisia/tratamento farmacológico , Pleurisia/patologia , Espondilite Anquilosante/tratamento farmacológico , Espondilite Anquilosante/patologia , Fator de Necrose Tumoral alfa/administração & dosagem , Humanos , Masculino , Pessoa de Meia-Idade , Pleurisia/complicações , Espondilite Anquilosante/complicações , Tomografia Computadorizada por Raios X
12.
Am J Med Sci ; 356(5): 487-491, 2018 11.
Artigo em Inglês | MEDLINE | ID: mdl-30055756

RESUMO

A 65-year-old man was admitted for productive cough and dyspnea. Bilateral pleural effusions were observed on chest X-ray. Although the bilateral pleural effusions were exudative with an increased number of lymphocytes, bacterial culture and polymerase chain reaction analysis for Mycobacterium tuberculosis were negative. Immunological examinations showed high levels of immunoglobulin G4 (IgG4) in both serum and pleural effusion fluid. Pathologic evaluation of a left pleural biopsy specimen using hematoxylin and eosin staining and immunohistochemical staining showed fibrosis-associated lymphoplasmacytic infiltration, 50 IgG4-positive plasma cells per high-power field, and an IgG4/IgG ratio of 40%. Thus, a diagnosis of IgG4-related pleuritis without other systemic manifestations was established. The bilateral pleural effusion improved following corticosteroid therapy. This is a rare case of IgG4-related pleuritis with no other organ involvement.


Assuntos
Imunoglobulina G/efeitos adversos , Derrame Pleural/diagnóstico , Pleurisia/diagnóstico , Corticosteroides/administração & dosagem , Idoso , Azatioprina/administração & dosagem , Humanos , Masculino , Derrame Pleural/tratamento farmacológico , Derrame Pleural/etiologia , Pleurisia/tratamento farmacológico , Pleurisia/etiologia , Prednisolona/administração & dosagem , Resultado do Tratamento
13.
J Int Med Res ; 46(7): 2976-2982, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-29756504

RESUMO

Although the infectious diseases tuberculosis (TB) and cryptococcosis both cause formation of single or multiple nodules in immunodeficient hosts, cases of co-infection of these diseases are rarely seen. We report a patient who was co-infected with TB and cryptococcosis. A male patient with no clinical evidence of immunodeficiency presented with a 3-week history of abdominal distension accompanied by oedema of recurring lower extremities. The patient was diagnosed with tuberculous peritonitis and tuberculous pleurisy by an abdominal puncture biopsy. Several months after being treated for TB, the patient was diagnosed with Cryptococcus infection and received antifungal treatment. Computed tomographic and magnetic resonance imaging findings suggested that treatment was effective. This case illustrates the challenges encountered during assessment of neoplasms associated with TB and cryptococcosis. Differential diagnosis requires an abdominal puncture biopsy. Diagnosis of Cryptococcus infection also requires a positive cryptococcal culture and positive India ink staining analysis. Notably, our patient also showed no obvious symptoms of cryptococcosis after receiving anti-TB treatment. Accordingly, in this report, we discuss the possible pathogenic mechanisms that underlie the coincidence of both types of inflammatory lesions. We emphasize the need for a greater awareness of atypical presentations of TB accompanied by Cryptococcus infection.


Assuntos
Coinfecção/diagnóstico , Criptococose/diagnóstico , Pneumopatias/diagnóstico , Peritonite Tuberculosa/diagnóstico , Pleurisia/diagnóstico , Tuberculose Pleural/diagnóstico , Antifúngicos/uso terapêutico , Antituberculosos/uso terapêutico , Coinfecção/tratamento farmacológico , Criptococose/tratamento farmacológico , Humanos , Pneumopatias/tratamento farmacológico , Masculino , Pessoa de Meia-Idade , Peritonite Tuberculosa/tratamento farmacológico , Pleurisia/tratamento farmacológico , Tuberculose Pleural/tratamento farmacológico
14.
J Ethnopharmacol ; 222: 79-86, 2018 Aug 10.
Artigo em Inglês | MEDLINE | ID: mdl-29729384

RESUMO

ETHNOPHARMACOLOGICAL RELEVANCE: Bromelia balansae is a relatively unexplored medicinal species that is used for nutritional purposes and in folk medicine to treat cough or wounds. AIM OF THIS STUDY: This study assessed the anti-inflammatory activity of the ethanolic extract obtained from Bromelia balansae fruit (EEBB) as well as the toxicological potential of this extract after single and repeated exposure. MATERIALS AND METHODS: Male rats (Wistar) were gavaged with 2000 mg/kg of extract from the fruit of B. balansae for the acute toxicity test and with 25, 100, or 400 mg/kg of EEBB for the subacute toxicity test. The anti-inflammatory effect of EEBB was evaluated in vivo (30, 100, or 300 mg/kg) by carrageenan (Cg) induced-oedema and pleurisy in Swiss mice. RESULTS: A single oral dose of EEBB did not result in toxicity, demonstrating that the LD50 of this extract was greater than 2000 mg/kg. In the subacute toxicity test, the tested doses produced no significant changes in the haematological, biochemical or histopathological parameters of treated animals. Similarly, there were no statistically significant differences in the sperm parameters. A dose of 300 mg/kg of EEBB significantly reduced oedema formation, Cg-induced mechanical hypersensitivity and cold sensitivity, as well as leukocyte migration in the pleurisy model. CONCLUSION: These results show that EEBB has an anti-inflammatory potential without causing acute or subacute toxicity. These data may contribute to the advancement of biopharmaceutical applications for this species.


Assuntos
Anti-Inflamatórios/toxicidade , Anti-Inflamatórios/uso terapêutico , Bromelia , Edema/tratamento farmacológico , Extratos Vegetais/toxicidade , Extratos Vegetais/uso terapêutico , Pleurisia/tratamento farmacológico , Animais , Anti-Inflamatórios/análise , Carragenina , Edema/induzido quimicamente , Etanol/química , Feminino , Flavonoides/análise , Flavonoides/uso terapêutico , Flavonoides/toxicidade , Frutas/química , Masculino , Camundongos , Extratos Vegetais/análise , Pleurisia/induzido quimicamente , Ratos Wistar , Solventes/química , Espermatozoides/efeitos dos fármacos , Testes de Toxicidade Aguda , Testes de Toxicidade Subaguda
15.
Chem Biol Interact ; 286: 1-10, 2018 Apr 25.
Artigo em Inglês | MEDLINE | ID: mdl-29499192

RESUMO

BACKGROUND: Indole-3-guanylhydrazone hydrochloride (LQM01) is a new derivative of aminoguanidine hydrochloride, an aromatic aminoguanidine. METHODS: Mice were treated with LQM01 (5, 10, 25 or 50 mg/kg, i.p.), vehicle (0.9% saline i.p.) or a standard drug. The mice were subjected to carrageenan-induced pleurisy, abdominal writhing induced by acetic acid, the formalin test and the hot-plate test. The model of non-inflammatory chronic muscle pain induced by saline acid was also used. Mice from the chronic protocol were assessed for withdrawal threshold, muscle strength and motor coordination. LQM01 or vehicle treated mice were evaluated for Fos protein. RESULTS: LQM01 inhibits TNF-α and IL-1ß production, as well as leukocyte recruitment during inflammation process. The level of IL-10 in LQM01-treated mice increased in pleural fluid. In addition, LQM01 decreased the nociceptive behavior in the acetic acid induced writhing test, the formalin test (both phases) and increased latency time on the hot-plate. LQM01 treatment also decreased mechanical hyperalgesia in mice with chronic muscle pain, with no changes in muscle strength and motor coordination. LQM01 reduced the number of Fos positive cells in the superficial dorsal horn. This compound exhibited antioxidant properties in in vitro assays. CONCLUSIONS: LQM01 has an outstanding anti-inflammatory and analgesic profile, probably mediated through a reduction in proinflammatory cytokines release, increase in IL-10 production and reduction in neuron activity in the dorsal horn of the spinal cord in mice. GENERAL SIGNIFICANCE: Beneficial effects of LQM01 suggest that it has some important clinical features and can play a role in the management of 'dysfunctional pain' and inflammatory diseases.


Assuntos
Analgésicos/química , Anti-Inflamatórios/química , Guanidinas/química , Interleucina-10/análise , Interleucina-1beta/análise , Fator de Necrose Tumoral alfa/análise , Analgésicos/farmacologia , Analgésicos/uso terapêutico , Animais , Anti-Inflamatórios/farmacologia , Anti-Inflamatórios/uso terapêutico , Antioxidantes/metabolismo , Comportamento Animal/efeitos dos fármacos , Carragenina/toxicidade , Guanidina/análogos & derivados , Indóis , Leucócitos/citologia , Leucócitos/efeitos dos fármacos , Leucócitos/metabolismo , Masculino , Camundongos , Microscopia de Fluorescência , Atividade Motora/efeitos dos fármacos , Força Muscular/efeitos dos fármacos , Dor/induzido quimicamente , Dor/tratamento farmacológico , Pleurisia/induzido quimicamente , Pleurisia/tratamento farmacológico , Proteínas Proto-Oncogênicas c-fos/metabolismo , Medula Espinal/metabolismo , Medula Espinal/patologia
16.
Intern Med ; 57(15): 2251-2257, 2018 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-29526951

RESUMO

An 81-year-old man was admitted with bilateral pleural effusion. A clinical examination showed lymphocytic pleura effusion and elevated serum IgG4 levels, so that IgG4-related disease was suggested, whereas tuberculous pleurisy was suspected because of high adenosine deaminase (ADA) levels in the pleural effusion. A surgical pleural biopsy revealed that there were large numbers of IgG4-positive cells and IgG4/IgG positive cell ratio exceeded 40% in several sites. Accordingly, we diagnosed IgG4-related pleuritis and treated with the patient with glucocorticoid therapy. The ADA levels in pleural effusion can increase in IgG4-related pleuritis, and it is therefore important to perform a pleural biopsy.


Assuntos
Imunoglobulina G/imunologia , Pleurisia/imunologia , Adenosina Desaminase/análise , Idoso de 80 Anos ou mais , Biópsia , Glucocorticoides/uso terapêutico , Humanos , Linfócitos/patologia , Masculino , Pleurisia/diagnóstico , Pleurisia/tratamento farmacológico
17.
Curr Opin Pulm Med ; 24(4): 367-373, 2018 07.
Artigo em Inglês | MEDLINE | ID: mdl-29538080

RESUMO

PURPOSE OF REVIEW: Pleural infection remains an important pulmonary disease, causing significant morbidity and mortality. There is a resurgence of disease burden despite introduction of antibiotics and pneumococcal vaccines. A revisit of the pathogenesis and update on intervention may improve the care of pleural infection. RECENT FINDINGS: Recent studies have uncovered the prognostic implication of the presence of a pleural effusion in patients with pneumonia. Identifying where the bacteria lives may have diagnostic and therapeutic implications. Over-exaggerated pleural inflammation may underlie development of parapneumonic effusion as indirect evidence and a randomized study in children raised a role of corticosteroids in parapneumonic pleural effusions, but data are lacking for adults. Optimization of the delivery regimen of intrapleural fibrinolytic and deoxyribonuclease therapy is ongoing. SUMMARY: The review aims to review the current practice and explore new directions of treatment on pleural infection.


Assuntos
Corticosteroides/uso terapêutico , Desoxirribonucleases/uso terapêutico , Empiema Pleural/tratamento farmacológico , Fibrinolíticos/uso terapêutico , Ativador de Plasminogênio Tecidual/uso terapêutico , Empiema Pleural/epidemiologia , Empiema Pleural/microbiologia , Humanos , Derrame Pleural/tratamento farmacológico , Derrame Pleural/microbiologia , Pleurisia/tratamento farmacológico
18.
Intern Med ; 57(13): 1887-1892, 2018 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-29434155

RESUMO

Yellow nail syndrome (YNS) pleurisy is often difficult to control, and pathological examinations have rarely been reported. We herein report a case of bucillamine-induced YNS in which histopathology of the parietal pleura revealed hyperplasia of the lymphoid follicles and lymphangiectasia. Even after the discontinuation of bucillamine, the pleurisy and lymphedema showed no change. Based on the histopathological findings showing similarity to rheumatoid pleurisy, we administered corticosteroid treatments, and both the pleurisy and lymphedema improved. The findings in the present case suggest that, in bucillamine-induced YNS, pleurisy may be related to inflammation caused by rheumatoid arthritis in addition to abnormalities in lymphatic vessels.


Assuntos
Anti-Inflamatórios não Esteroides/efeitos adversos , Cisteína/análogos & derivados , Linfangiectasia/complicações , Linfedema/complicações , Síndrome das Unhas Amareladas/induzido quimicamente , Síndrome das Unhas Amareladas/complicações , Corticosteroides/uso terapêutico , Idoso de 80 Anos ou mais , Anti-Inflamatórios não Esteroides/uso terapêutico , Artrite Reumatoide/complicações , Artrite Reumatoide/tratamento farmacológico , Cisteína/efeitos adversos , Cisteína/uso terapêutico , Feminino , Humanos , Hiperplasia , Inflamação/complicações , Linfedema/tratamento farmacológico , Pleurisia/complicações , Pleurisia/tratamento farmacológico , Síndrome das Unhas Amareladas/patologia
19.
BMJ Case Rep ; 20182018 Feb 08.
Artigo em Inglês | MEDLINE | ID: mdl-29437801

RESUMO

We report two cases of pleurisy caused by non-tuberculous mycobacteria followed by pneumothorax. The onset of pleurisy was accompanied by acute fever. Cultured samples of the pleural effusions from the two patients, an 80-year-old man and an 87-year-old woman, were ultimately found to contain Mycobacterium intracellulare and Mycobacterium kansasii, respectively. Both patients were initially administered antibiotics, but their fevers persisted. Therefore, different combinations of antimycobacterial drugs were used, which reduced the fever in a few days. In these patients, pleurisy caused by non-tuberculous mycobacteria followed by pneumothorax was characterised by acute fever and improvement in the fever after administration of antimycobacterial drugs; however, the aetiology remains to be clarified.


Assuntos
Antibacterianos/uso terapêutico , Antituberculosos/uso terapêutico , Infecções por Micobactéria não Tuberculosa/tratamento farmacológico , Infecção por Mycobacterium avium-intracellulare/tratamento farmacológico , Pleurisia/tratamento farmacológico , Idoso de 80 Anos ou mais , Quimioterapia Combinada , Feminino , Febre/etiologia , Humanos , Pulmão/diagnóstico por imagem , Masculino , Infecções por Micobactéria não Tuberculosa/diagnóstico , Infecções por Micobactéria não Tuberculosa/microbiologia , Complexo Mycobacterium avium/isolamento & purificação , Infecção por Mycobacterium avium-intracellulare/diagnóstico , Infecção por Mycobacterium avium-intracellulare/microbiologia , Mycobacterium kansasii/isolamento & purificação , Pleurisia/diagnóstico , Pleurisia/microbiologia , Radiografia , Tomografia Computadorizada por Raios X , Resultado do Tratamento
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