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1.
J Chem Phys ; 151(12): 124706, 2019 Sep 28.
Artigo em Inglês | MEDLINE | ID: mdl-31575160

RESUMO

Most theories of the binding of molecules to surfaces or for the association between molecules treat the binding species as structureless entities and neglect their rigidity and the changes in their stiffness induced by the binding process. The binding species are also taken to be "ideal," meaning that the existence of van der Waals interactions and changes in these interactions upon molecular binding are also neglected. An understanding of the thermodynamics of these multifunctional molecular binding processes has recently come into focus in the context of the molecular binding of complex molecules, such as dendrimers and DNA grafted nanoparticles, to surfaces where the degree of binding cooperativity and selectivity, as well as the location of the binding transition, are found to be sensitive to the number of binding units constrained to a larger scale polymeric scaffold. We address the fundamental problem of molecular binding by extending classical Langmuir theory to describe the particular example of the reversible binding of semiflexible polymer chains to a solid substrate under melt conditions. The polymer chains are assumed to have a variable number N of binding units (segments) and to exhibit variable bending energies and van der Waals interactions in the bulk and on the surface, in addition to strong directional interactions with the surface. The resulting generalized Langmuir theory is applied to the examination of the influence of the chain connectivity of ideal polymers on the surface coverage Θ, transition binding temperature T1/2 at which Θ = 1/2, and on the derivative |dΘ/dT|T=T1/2 and the constant volume specific heat of binding, Cv bind, measures of the cooperativity and "sharpness" of the binding transition, respectively. Paper II is devoted to the impact of the van der Waals attractive interactions and chain stiffness on the reversible binding of nonideal polymer chains to a solid surface, including the enthalpy-entropy compensation phenomenon observed experimentally in many molecular and particle binding processes.


Assuntos
Modelos Químicos , Polímeros/química , Adsorção , Congelamento , Termodinâmica
2.
Phys Chem Chem Phys ; 21(37): 20999-21006, 2019 Oct 07.
Artigo em Inglês | MEDLINE | ID: mdl-31528872

RESUMO

A substantial number of diseases leading to loss of neurologic functions such as Morbus Alzheimer, Morbus Parkinson, or Chorea Huntington are related to the fibrillation of particular amyloidogenic peptides. In vitro amyloid fibrillation strongly depends on admixture with other proteins and peptides, lipids, nanoparticles, surfactants and polymers. We investigated amyloid-beta 1-40 peptide (Aß1-40) fibrillation in mixture with thermoresponsive poly(oligo(ethylene glycol)macrylates), in which the polymer's hydrophobicity is tuned by variation of the number of ethylene glycol-units in the side chain (m = 1-9), the end groups (B = butoxy; C = carboxy; D = dodecyl; P = pyridyldisulfide) and the degree of polymerization (n) of the polymers. The polymers were prepared via RAFT-polymerization, obtaining a broad range of molecular masses (Mn = 700 to 14 600 g mol-1 kDa-1, polydispersity indices PDI = 1.10 to 1.25) and tunable cloud point temperatures (Tcp), ranging from 42.4 °C to 80 °C, respectively. Proper combination of hydrophobic end groups with hydrophilic side chains of the polymer allowed to alter the hydrophilicity/hydrophobicity of these polymers, which is shown to enhance Aß1-40 aggregation significantly in case of the endgroup D (with n = 16, 23, 56). We observed that the less hydrophilic polymers (m = 1-2) were able to both decrease and elongate the lag (tlag) and characteristic times (tchar) of Aß1-40 fibril formation in dependence of their end groups, molecular mass and hydrophilicity. On the other hand, highly hydrophilic polymers (m = 3, 5, 9) either decreased, or only marginally influenced the lag and characteristic times of Aß1-40 fibrillation, in all cases forming ß-sheet rich fibrils as observed by TEM and CD-spectroscopy. Our results support that balanced hydrophobic and hydrophilic interactions of a polymer with Aß1-40 is important for inhibiting amyloid-formation pathways.


Assuntos
Peptídeos beta-Amiloides/química , Fragmentos de Peptídeos/química , Polímeros/química , Amiloide/química , Amiloide/ultraestrutura , Peptídeos beta-Amiloides/ultraestrutura , Interações Hidrofóbicas e Hidrofílicas , Fragmentos de Peptídeos/ultraestrutura
3.
Chem Commun (Camb) ; 55(66): 9829-9832, 2019 Aug 13.
Artigo em Inglês | MEDLINE | ID: mdl-31363730

RESUMO

Polyethylene glycol grafted pyrrole-based conjugated polymers are synthesized through a one-pot multicomponent methodology, the self-assemblies of which enable nanoparticle size-selective encapsulation of drug molecules and their sustained release. Efficient loading of curcumin through drug-nanoparticle core interactions is probed using FRET, and the inherently fluorescent nature of polypyrrole could be used to detect these nanocarriers intracellularly.


Assuntos
Portadores de Fármacos , Nanopartículas/química , Polietilenoglicóis/química , Polímeros/química , Pirróis/química , Linhagem Celular Tumoral , Curcumina/administração & dosagem , Transferência Ressonante de Energia de Fluorescência , Humanos , Interações Hidrofóbicas e Hidrofílicas , Concentração Inibidora 50 , Microscopia Eletrônica de Transmissão , Espectrofotometria Ultravioleta
4.
J Agric Food Chem ; 67(37): 10481-10488, 2019 Sep 18.
Artigo em Inglês | MEDLINE | ID: mdl-31433940

RESUMO

Here, we report two methods that chemically modify alginate to achieve neutral-basic pH sensitivity of the resultant hydrogel. The first method involves direct amide bond formation between alginate and 4-(2-aminoethyl)benzoic acid. The second method that arose out of the desire to achieve better control of the degradation rate of the alginate hydrogel involves reductive amination of oxidized alginate. The products of both methods result in a hydrogel vehicle for targeted delivery of encapsulated payload under physiological conditions in the gastrointestinal tract. Two-dimensional diffusion-ordered spectroscopy and internal and coaxial external nuclear magnetic resonance standards were used to establish chemical bonding and percent incorporation of the modifying groups into the alginate polymer. The hydrogel made with alginate modified by each method was found to be completely stable under acidic pH conditions while disintegrating within minutes to hours in neutral-basic pH conditions. We found that, while alginate oxidation did not affect the ß-d-mannuronate/α-l-guluronate ratio of alginate, the rate of disintegration of the hydrogel made with oxidized alginate was dependent upon the degree of oxidation.


Assuntos
Alginatos/química , Portadores de Fármacos/química , Sistemas de Liberação de Medicamentos/instrumentação , Administração Oral , Difusão , Hidrogéis/química , Concentração de Íons de Hidrogênio , Oxirredução , Polímeros/química
5.
Inorg Chem ; 58(17): 11294-11299, 2019 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-31411862

RESUMO

The first two examples of polyoxopalladates(II) (POPs) containing tetravalent metal ion guests, [MO8Pd12(PO4)8]12- (M = SnIV, PbIV), have been prepared and structurally characterized in the solid state, solution, and gas phase. The interactions of the metal ion guests and the palladium-oxo shell were studied by theoretical calculations. The POPs were shown to possess anticancer activity by causing oxidative stress inducing caspase activation and consecutive apoptosis of leukemic cells.


Assuntos
Antineoplásicos/farmacologia , Metais Pesados/química , Compostos Organometálicos/farmacologia , Polímeros/química , Antineoplásicos/síntese química , Antineoplásicos/química , Morte Celular/efeitos dos fármacos , Proliferação de Células/efeitos dos fármacos , Cristalografia por Raios X , Ensaios de Seleção de Medicamentos Antitumorais , Células HL-60 , Humanos , Íons/química , Modelos Moleculares , Compostos Organometálicos/síntese química , Compostos Organometálicos/química
6.
Eur J Histochem ; 63(3)2019 Aug 06.
Artigo em Inglês | MEDLINE | ID: mdl-31455073

RESUMO

RNA interference is a powerful approach to understand gene function both for therapeutic and experimental purposes. Since the lack of knowledge in the gene silencing of various hepatic cell lines, this work was aimed to compare two transfection agents, the liposome-based Lipofectamine™ RNAiMAX and the HepG2-specific, polymer-based GenMute™, in two cellular models of human hepatoma, HepG2 and Huh7.5. In the first part, we assessed transfection efficiency of a fluorescent Cy3-labeled negative control siRNA by cell imaging analysis; we found that cells treated with GenMute present a higher uptake of the fluorescent negative control siRNA when compared to Lipofectamine RNAiMAX-transfected cells, both in HepG2 and in Huh7.5 cells. In the second part, we evaluated GAPDH silencing with the two transfection reagents by RT-PCR similar GAPDH mRNA expression after each transfection treatment. Finally, we measured cell viability by the MTT assay, observing that cells transfected with GenMute have higher viability with respect to Lipofectamine RNAiMAX-administered cells. These results suggest that GenMute reagent might be considered the most suitable transfection agent for hepatic gene silencing.


Assuntos
Técnicas de Transferência de Genes , Lipídeos/química , Polímeros/química , RNA Interferente Pequeno/genética , Transfecção/métodos , Sequência de Bases , Carbocianinas/química , Carbocianinas/metabolismo , Carcinoma Hepatocelular/genética , Linhagem Celular Tumoral , Sobrevivência Celular/efeitos dos fármacos , Corantes Fluorescentes/química , Corantes Fluorescentes/metabolismo , Inativação Gênica , Gliceraldeído-3-Fosfato Desidrogenases/genética , Humanos , Metabolismo dos Lipídeos , Lipídeos/toxicidade , Lipossomos/química , Lipossomos/metabolismo , Lipossomos/toxicidade , Neoplasias Hepáticas/genética , Polímeros/metabolismo , Polímeros/toxicidade , Interferência de RNA
7.
Analyst ; 144(17): 5261-5270, 2019 Sep 07.
Artigo em Inglês | MEDLINE | ID: mdl-31364612

RESUMO

In this work, an enrichment approach for the profiling of N-linked glycans was developed by utilizing a highly porous 3D graphene composite fabricated from graphene oxide nanosheets and a phenol-formaldehyde polymer via graphitization and KOH activation. In tailoring the large surface area (ca. 2213 m2 g-1) and 3D-layered mesoporous structure, the 3D graphene composite demonstrated not only high efficiency in glycan enrichment but also the size-exclusion effect against residual protein interference. For a standard protein ovalbumin digest, 26 N-linked glycans were identified with good repeatability, and the detection limit was as low as 0.25 ng µL-1 with the identification of 13 N-linked glycans (S/N > 10). When the mass ratio of the ovalbumin digest to the interfering proteins, i.e., bovine serum albumin and ovalbumin was 1 : 2000 : 2000, 18 N-linked glycans could still be detected with sufficient signal intensities. From a 60 nL minute complex human serum sample, up to 53 N-linked glycans with S/N > 10 were identified after the 3D graphene enrichment, while only 20 N-linked glycans were identified by the porous graphitized carbon material used for comparison. In addition, the application of the 3D graphene composite in profiling the up-regulated and down-regulated N-linked glycans from the real clinical serum samples of ovarian cancer patients confirmed the potential of the 3D graphene composite for analyzing minute and complicated biological samples.


Assuntos
Grafite/química , Nanoestruturas/química , Ovalbumina/química , Polissacarídeos/análise , Albumina Sérica/química , Feminino , Formaldeído/química , Humanos , Neoplasias Ovarianas/sangue , Oxirredução , Fenol/química , Fenóis/química , Polímeros/química , Polissacarídeos/isolamento & purificação , Porosidade , Soro
8.
Int J Nanomedicine ; 14: 5415-5434, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31409996

RESUMO

Over the past two decades, nano-sized biosystems have increasingly been utilized to deliver various pharmaceutical agents to a specific region, organ or tissue for controllable precision therapy. Whether solid nanohydrogel, nanosphere, nanoparticle, nanosheet, micelles and lipoproteins, or "hollow" nanobubble, liposome, nanocapsule, and nanovesicle, all of them can exhibit outstanding loading and releasing capability as a drug vehicle - in particular polymeric nanovesicle, a microscopic hollow sphere that encloses a water core with a thin polymer membrane. Besides excellent stability, toughness and liposome-like compatibility, polymeric nanovesicles offer considerable scope for tailoring properties by changing their chemical structure, block lengths, stimulus-responsiveness and even conjugation with biomolecules. In this review, we summarize the latest advances in stimulus-responsive polymeric nanovesicles for biomedical applications. Different functionalized polymers are in development to construct more complex multiple responsive nanovesicles in delivery systems, medical imaging, biosensors and so on.


Assuntos
Sistemas de Liberação de Medicamentos , Técnicas de Transferência de Genes , Nanopartículas/química , Polímeros/química , Portadores de Fármacos/química , Concentração de Íons de Hidrogênio
9.
Chem Commun (Camb) ; 55(67): 10023-10026, 2019 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-31378804

RESUMO

Inspired by the formation mechanism of a biological membrane potential, we described the generation of an artificial membrane potential through redox-regulating anion distribution on the two sides of a polypyrrole film. The polarity of the membrane potential could be regulated by the redox reaction.


Assuntos
Materiais Biomiméticos/química , Polímeros/química , Pirróis/química , Técnicas Eletroquímicas , Potenciais da Membrana , Membranas Artificiais , Oxirredução
10.
J Agric Food Chem ; 67(32): 8938-8949, 2019 Aug 14.
Artigo em Inglês | MEDLINE | ID: mdl-31361121

RESUMO

Polymeric pigments formed via ethyl linkages between grape tannins and anthocyanins are important to the development of stable red wine color. To determine the effect of tannin structure on the stability and color properties of ethyl-linked polymeric pigments, tannin fractions with average polymerization between 4 and 43 units were prepared from grape skins and seeds and combined with malvidin-3-glucoside (M3G) in model wine containing acetaldehyde. As tannin molecular mass increased, the reaction rate with M3G increased. Compared with skin tannins of comparable molecular mass, seed tannins reacted more rapidly with M3G but were prone to precipitation. This resulted in a loss of polymeric pigments formed from seed tannins, which was greater as tannin molecular mass increased. Aggregation occurred following the reaction of seed tannin with M3G, concomitant with precipitation. The aggregation-precipitation phenomenon was not observed for skin tannin-derived pigments, indicating a greater stability in solution than those formed from seed tannins.


Assuntos
Acetaldeído/química , Antocianinas/química , Pigmentos Biológicos/química , Extratos Vegetais/química , Sementes/química , Taninos/química , Vitis/química , Precipitação Química , Cor , Frutas/química , Cinética , Peso Molecular , Polimerização , Polímeros/química
11.
Phys Chem Chem Phys ; 21(32): 17475-17493, 2019 Aug 15.
Artigo em Inglês | MEDLINE | ID: mdl-31328203

RESUMO

A set of disordered interacting building blocks may form ordered structures by means of a self-assembling process. An external intervention in the system by adding a chemical species or by applying forces leads to different self-assembly scenarios with the appearance of new structures. For instance, the formation of microtubules, gels, virus capsides, cells and living beings among others takes place by self-assembly under nonequilibrium conditions. A general evolution criterion able to account for why nature selects some structures outside equilibrium and not others is lacking. Nevertheless, progress in the understanding of nonequilibrium self-assembly (NESA) mechanisms has been made thanks to the formulation of models that take particular situations into consideration. We review recent efforts devoted to describing self-assembly out of equilibrium and we provide a reference linking several current concepts in order to help in the development of new models and experimental studies. We hope that the knowledge of the intimate mechanisms leading to the formation of structures will make the implementation of re-configurable and bio-inspired materials possible and give a simpler perspective on the understanding of the emergence of life.


Assuntos
Modelos Teóricos , Fenômenos Físicos , Fenômenos Biofísicos , Células/química , Géis/química , Cinética , Método de Monte Carlo , Nanopartículas/química , Polímeros/química , Termodinâmica , Vírus/química
12.
J Agric Food Chem ; 67(32): 8715-8724, 2019 Aug 14.
Artigo em Inglês | MEDLINE | ID: mdl-31339713

RESUMO

Natural plant fibers have been widely used in the agricultural and forest industries, and even in the automobile industry, especially for producing fiber reinforced polymer matrix composites. However, the low mechanical properties of composites remain the key problem in the applications. A hyperbranched polymer has lots of advantages such as low viscosity, high reactivity, and so on. Multireactive end groups of hyperbranched polymers are ideal for modifying natural plant fibers to achieve better interface bonding between a fiber and resin matrix. This manuscript reviews some research advances in hyperbranched-polymer-modified natural plant fibers and summarizes the applications of the modified fibers in polymer matrix composites with a particular focus on the chemical modification of fibers and interface bonding.


Assuntos
Extratos Vegetais/química , Plantas/química , Polímeros/química , Propriedades de Superfície
13.
Chem Soc Rev ; 48(16): 4347-4360, 2019 Aug 12.
Artigo em Inglês | MEDLINE | ID: mdl-31263808

RESUMO

To exert its role of a functional polymer, DNA relies on a molecular self-assembly process that is driven by the interactions of only four units placed in a defined order. Extending the structural diversity of recognition motifs in DNA, to and beyond analogues of the nucleobases, will open doors to self-assembled materials with advanced programmable properties. DNA-inspired systems are becoming useful for numerous applications unachievable by the nucleic acids in their native composition. Potential applications of rationally designed oligo- and polyphosphodiesters reside in the areas of drug delivery, diagnostic signalling and imaging, in systems for efficient energy transfer or the precise ordering on the nanoscale. The field of DNA-inspired phosphodiesters highlights the general value and utility of precision in the composition of oligomers and polymers. In this tutorial review, we will summarize the approaches of directing the self-assembly of DNA-inspired, sequence-specific polyphosphodiesters into soft materials with unique properties. These data expose the so far underexploited potential of DNA-derived systems in solving some of the key issues in various technological areas, such as advanced biomaterials, morphologically defined soft matter or the controlled polymer folding and assembly. Moreover, precise positioning of structurally diverse molecules within a polymer chain creates unmatched opportunities for encoding information on the molecular level and transmitting it further to the microscopic and even macroscopic level via noncovalent interactions.


Assuntos
DNA/química , Polímeros/química , Azidas/química , Lipossomos/química , Compostos Organofosforados/química , Polímeros/síntese química
14.
J Chromatogr A ; 1602: 178-187, 2019 Sep 27.
Artigo em Inglês | MEDLINE | ID: mdl-31301797

RESUMO

A magnetic porous covalent triazine-based organic polymer (M-PCTP) was synthesized by co-precipitation method. The M-PCTP combined both the properties of the PCTP and the magnetism of Fe3O4 nanoparticles, possessing highly porous structure and good magnetism. It was used as a magnetic solid phase extraction (MSPE) adsorbent to extract carbamate pesticides (propoxur, carbaryl, isoprocarb, fenobcarb and diethofencarb) from lemonade and grape juice samples prior to high performance liquid chromatography-mass spectrometric detection. Under the optimal conditions, a good linearity for the real samples was received in the range from 0.10-0.90 to 80.00 ng mL-1 with the correlation coefficients of 0.9882-0.9983. The method recoveries for the five carbamates were 86.3-108.0%. The limits of detection were 0.02-0.20 ng mL-1 for lemonade sample, and 0.04-0.30 ng mL-1 for grape juice sample. The M-PCTP also demonstrated good extraction capabilities for other different kinds of organic compounds including chlorophenols and polycyclic aromatic hydrocarbons.


Assuntos
Carbamatos/isolamento & purificação , Cromatografia Líquida de Alta Pressão , Análise de Alimentos/métodos , Espectrometria de Massas , Praguicidas/análise , Extração em Fase Sólida , Sucos de Frutas e Vegetais/análise , Magnetismo , Hidrocarbonetos Policíclicos Aromáticos/análise , Polímeros/química , Porosidade
15.
Chem Commun (Camb) ; 55(64): 9487-9490, 2019 Aug 07.
Artigo em Inglês | MEDLINE | ID: mdl-31328194

RESUMO

We designed 1300 nm absorption semiconducting polymer nanoparticles (SPNs3) based on a two-acceptor semiconducting polymer to realize in vivo NIR-II photothermal therapy (PTT) treatment guided by commercial small-animal NIR-II photoacoustic imaging (PAI) systems.


Assuntos
Nanopartículas/química , Técnicas Fotoacústicas/métodos , Polímeros/química , Espectroscopia de Luz Próxima ao Infravermelho/métodos , Animais , Linhagem Celular Tumoral , Camundongos
16.
J Microbiol Biotechnol ; 29(7): 1009-1013, 2019 Jul 28.
Artigo em Inglês | MEDLINE | ID: mdl-31288302

RESUMO

Polymeric nanoparticles are widely used for drug delivery due to their biodegradability property. Among the wide array of polymers, chitosan has received growing interest among researchers. It was widely used as a vehicle in polymeric nanoparticles for drug targeting. This review explored the current research on the antimicrobial activity of chitosan nanoparticles (ChNP) and the impact on the clinical applications. The antimicrobial activities of ChNP were widely reported against bacteria, fungi, yeasts and algae, in both in vivo and in vitro studies. For pharmaceutical applications, ChNP were used as antimicrobial coating for promoting wound healing, preventing infections and combating the rise of infectious disease. Besides, ChNP also exhibited significant inhibitory on foodborne microorganisms, particularly on fruits and vegetables. It is noteworthy that ChNP can be also applied to deliver antimicrobial drugs, which further enhance the efficiency and stability of the antimicrobial agent. The present review addresses the potential antimicrobial applications of ChNP from these few aspects.


Assuntos
Anti-Infecciosos/química , Anti-Infecciosos/farmacologia , Bactérias/efeitos dos fármacos , Quitosana/química , Portadores de Fármacos/química , Fungos/efeitos dos fármacos , Nanopartículas/química , Materiais Biocompatíveis , Sistemas de Liberação de Medicamentos , Humanos , Nanotecnologia , Polímeros/química
18.
Chem Commun (Camb) ; 55(65): 9681-9684, 2019 Aug 21.
Artigo em Inglês | MEDLINE | ID: mdl-31347618

RESUMO

Here, we report a convenient, fast labeling strategy for the imaging of cell surface sialic acids (SAs, nine-carbon monosaccharides located at the terminals of cell surface sugar chains). This strategy is based on the synthesis of sticky, furry and fluorescent "wool-balls", which are wound into nanoclusters from p-benzoquinone/ethylenediamine polymer "wires". With abundant amino groups at the surface, the wool-balls can easily stick to the C-7 aldehyde group generated at the ends of periodate treated SAs in less than 30 min.


Assuntos
Benzoquinonas/química , Etilenodiaminas/química , Corantes Fluorescentes/química , Nanopartículas/química , Polímeros/química , Ácidos Siálicos/análise , Animais , Benzoquinonas/síntese química , Linhagem Celular Tumoral , Etilenodiaminas/síntese química , Fluorescência , Humanos , Camundongos , Microscopia de Fluorescência/métodos , Neuraminidase/química , Tamanho da Partícula , Polímeros/síntese química , Células RAW 264.7 , Bases de Schiff/síntese química , Bases de Schiff/química , Ácidos Siálicos/química
19.
J Nanobiotechnology ; 17(1): 82, 2019 Jul 10.
Artigo em Inglês | MEDLINE | ID: mdl-31291960

RESUMO

Skin damages are defined as one of most common lesions people suffer from, some of wounds are notoriously difficult to eradicate such as chronic wounds and deep burns. Existing wound therapies have been proved to be inadequate and far from satisfactory. The cutting-edge nanotechnology offers an unprecedented opportunity to revolutionize and invent new therapies or boost the effectiveness of current medical treatments. In particular, the nano-drug delivery systems anchor bioactive molecules to applied area, sustain the drug release and explicitly enhance the therapeutic efficacies of drugs, thus making a fine figure in field relevant to skin regeneration. This review summarized and discussed the current nano-drug delivery systems holding pivotal potential for wound healing and skin regeneration, with a special emphasis on liposomes, polymeric nanoparticles, inorganic nanoparticles, lipid nanoparticles, nanofibrous structures and nanohydrogel.


Assuntos
Materiais Biocompatíveis/química , Sistemas de Liberação de Medicamentos/métodos , Nanopartículas/química , Fenômenos Fisiológicos da Pele , Cicatrização/efeitos dos fármacos , Animais , Liberação Controlada de Fármacos , Humanos , Hidrogéis/química , Lipídeos/química , Lipossomos/química , Polímeros/química , Regeneração
20.
J Phys Chem Lett ; 10(14): 4123-4128, 2019 Jul 18.
Artigo em Inglês | MEDLINE | ID: mdl-31287699

RESUMO

Delivering potential theranostic metal complexes into preferential cellular targets is becoming of increasing interest. Here we report that nuclear uptake of a cell-impermeable DNA "light-switching" Ru(II)-polypyridyl complex can be significantly facilitated by chlorophenolate counter-anions, which was found, unexpectedly, to be correlated positively with the binding stability but inversely with the lipophilicity of the formed ion pairs.


Assuntos
Clorofenóis/química , Complexos de Coordenação/química , DNA/química , Piridinas/química , Rutênio/química , Química Física , Células HeLa , Humanos , Íons/química , Estrutura Molecular , Polímeros/química
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