Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 535
Filtrar
2.
J Stroke Cerebrovasc Dis ; 28(11): 104306, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31439523

RESUMO

Carotid-Cavernous sinus fistula (CCF) caused by a ruptured aneurysm of persistent primitive trigeminal artery (PPTA) is exceptionally rare. Herein, we reported the case of a 64-year-old female who presented with headache, pulsatile tinnitus, and diplopia. Angiography showed a PPTA and CCF. Three-dimensional digital subtraction angiograms revealed a direct shunt between the PPTA aneurysm and the left cavernous sinus. The trigeminal carotid fistula was successfully treated with detachable coils and Onyx, and the PPTA was preserved. Hence, coil and Onyx occlusion of the cavernous sinus is a safe and effective treatment for trigeminal carotid fistula.


Assuntos
Aneurisma Roto/etiologia , Artéria Basilar/anormalidades , Artéria Carótida Interna/anormalidades , Fístula Carotidocavernosa/etiologia , Malformações Vasculares do Sistema Nervoso Central/complicações , Aneurisma Intracraniano/etiologia , Aneurisma Roto/diagnóstico por imagem , Aneurisma Roto/terapia , Artéria Basilar/diagnóstico por imagem , Artéria Carótida Interna/diagnóstico por imagem , Fístula Carotidocavernosa/diagnóstico por imagem , Fístula Carotidocavernosa/terapia , Malformações Vasculares do Sistema Nervoso Central/diagnóstico por imagem , Combinação de Medicamentos , Embolização Terapêutica/instrumentação , Feminino , Humanos , Aneurisma Intracraniano/diagnóstico por imagem , Aneurisma Intracraniano/terapia , Pessoa de Meia-Idade , Polivinil/administração & dosagem , Tantálio/administração & dosagem , Resultado do Tratamento
3.
Eur J Pharm Sci ; 139: 105043, 2019 Nov 01.
Artigo em Inglês | MEDLINE | ID: mdl-31415903

RESUMO

Amorphous solid dispersion stands out among different formulation strategies for the improvement of dissolution rate and bioavailability via generating supersaturated drug solution, which provides a higher solubility than the crystalline counterpart, leading to a promoted intestinal absorption. Soluplus (SOL), termed as the fourth generation of solid dispersion carrier, presented a preferable effect on supersaturation maintaining and bioavailability enhancement for poorly water soluble drugs. However, some binary drug/SOL systems still suffer from insufficient dissolution and unsatisfied in vivo absorption. Thus, taking Lacidipine (LCDP) as a model drug, the aim of this study was to explore a ternary amorphous solid dispersion consisted of SOL and a surfactant to further increasing the dissolution rate and in vivo absorption. First of all, various surfactants were screened via equilibrium solubility enhancement and sodium dodecyl sulfate (SDS) was selected as the most effective candidate. Thereafter, the influence of SOL/SDS and drug/carrier weight ratio on the supersaturation maintaining was investigated. The supersaturated drug solutions were spray dried and the in vitro release, pharmacokinetic behavior as well as physical stability were investigated. It was found that although combination use of SOL and SDS did not present remarkable advantage in supersaturation maintenance in liquid state, 6-7 times higher dissolution rate under non-sink condition was noticed at SOL/SDS ratio 3:1 after spray drying, for LCDP/SOL/SDS based formulation compared to that of the binary LCDP/SOL system, which was maintained even after 92.5% humidity and 60 °C accelerated stability test. Moreover, compared to the LCDP/SOL formulation, approximately 3.3 and 3.7-fold increase in C max and AUC0-∞ was achieved with LCDP/SOL/SDS based formulation. In conclusion, the presented SDS could not only be regarded as solubility enhancer but also dissolution or bioavailability promoter, highlighting its potential application in ternary supersaturable amorphous solid dispersion for further increasing the dissolution and in vivo absorption of poorly water soluble drugs.


Assuntos
Di-Hidropiridinas/administração & dosagem , Portadores de Fármacos/administração & dosagem , Excipientes/administração & dosagem , Polietilenoglicóis/administração & dosagem , Polivinil/administração & dosagem , Dodecilsulfato de Sódio/administração & dosagem , Tensoativos/administração & dosagem , Animais , Disponibilidade Biológica , Di-Hidropiridinas/química , Di-Hidropiridinas/farmacocinética , Portadores de Fármacos/química , Portadores de Fármacos/farmacocinética , Liberação Controlada de Fármacos , Estabilidade de Medicamentos , Excipientes/química , Excipientes/farmacocinética , Absorção Intestinal/efeitos dos fármacos , Polietilenoglicóis/química , Polietilenoglicóis/farmacocinética , Polivinil/química , Polivinil/farmacocinética , Ratos Sprague-Dawley , Dodecilsulfato de Sódio/química , Dodecilsulfato de Sódio/farmacocinética , Tensoativos/química , Tensoativos/farmacocinética
4.
Int J Pharm ; 566: 329-341, 2019 Jul 20.
Artigo em Inglês | MEDLINE | ID: mdl-31152793

RESUMO

Staphylococcal biofilms cause many infectious diseases and are highly tolerant to the effects of antimicrobials; this is partly due to the biofilm matrix, which acts as a physical barrier retarding the penetration and reducing susceptibility to antimicrobials, thereby decreasing successful treatment outcomes. In this study, both single and mixed micellar systems based on poly vinyl caprolactam (PCL)-polyethylene glycol (PEG) copolymers were optimised for delivery of chlorhexidine (CHX) to S. aureus, MRSA and S. epidermidis biofilms and evaluated for their toxicity using Caenorhabditis elegans. The respective polyethylene glycol (PEG) and poly vinyl caprolactam (PCL) structural components promoted stealth properties and enzymatic responsive release of CHX inside biofilms, leading to significantly enhanced penetration (56%) compared with free CHX and improving the efficacy against Staphylococcus aureus biofilms grown on an artificial dermis (2.4 log reduction of CFU). Mixing Soluplus-based micelles with Solutol further enhanced the CHX penetration (71%) and promoted maximum reduction in biofilm biomass (>60%). Nematodes-based toxicity assay showed micelles with no lethal effects as indicated by their high survival rate (100%) after 72 h exposure. This study thus demonstrated that bio-responsive carriers can be designed to deliver a poorly water-soluble antimicrobial agent and advance the control of biofilm associated infections.


Assuntos
Anti-Infecciosos/administração & dosagem , Clorexidina/administração & dosagem , Óxido de Etileno/administração & dosagem , Lactonas/administração & dosagem , Micelas , Polietilenoglicóis/administração & dosagem , Polivinil/administração & dosagem , Staphylococcus aureus/efeitos dos fármacos , Staphylococcus epidermidis/efeitos dos fármacos , Animais , Anti-Infecciosos/toxicidade , Biofilmes/efeitos dos fármacos , Caenorhabditis elegans/efeitos dos fármacos , Clorexidina/toxicidade , Óxido de Etileno/toxicidade , Lactonas/toxicidade , Polietilenoglicóis/toxicidade , Polivinil/toxicidade , Pele Artificial/microbiologia , Staphylococcus aureus/fisiologia , Staphylococcus epidermidis/fisiologia
5.
J Neurointerv Surg ; 11(10): 1040-1044, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31147436

RESUMO

BACKGROUND AND PURPOSE: Liquid embolic agents (LEAs) are the determinant tool for successful embolization of cranial arteriovenous shunts. There are few currently available LEAs. The aim of the study was to summarize our initial experience with a recently introduced non-adhesive ethylene vinyl alcohol (EVOH) copolymer based LEA (Menox 18) in the endovascular treatment of cerebral arteriovenous malformations. METHODS: From April 2018 to November 2018, 24 patients harboring cerebral arteriovenous malformations underwent endovascular embolization with Menox 18. Clinical features, angiographic results, procedural details, complications, and follow-up details were prospectively collected and retrospectively analyzed. RESULTS: Curative embolization in one endovascular session was achieved in 14/24 (58.3%) of the treated patients. Partial embolization was achieved in 10 patients (42.6%) in whom staged treatment with radiosurgery or microsurgical resection was planned. No mortality was recorded in our series. Clinical complications after embolization occurred in 1/24 (4.66%) patients. No technical complications were noted CONCLUSIONS: Our pilot study suggests that the Menox embolization system offers similar technical and clinical results in comparison with the other currently available LEAs. Further studies with larger cohorts and long term follow-up data are needed to fully evaluate its efficacy.


Assuntos
Fístula Arteriovenosa/terapia , Embolização Terapêutica/métodos , Procedimentos Endovasculares/métodos , Malformações Arteriovenosas Intracranianas/terapia , Polivinil/administração & dosagem , Adolescente , Adulto , Idoso , Fístula Arteriovenosa/diagnóstico por imagem , Criança , Pré-Escolar , Feminino , Humanos , Malformações Arteriovenosas Intracranianas/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Projetos Piloto , Estudos Prospectivos , Estudos Retrospectivos , Resultado do Tratamento , Adulto Jovem
6.
Int J Pharm ; 566: 594-603, 2019 Jul 20.
Artigo em Inglês | MEDLINE | ID: mdl-31175988

RESUMO

Limited supersaturation maintaining duration is the main challenge for amorphous solid dispersion design. Nucleation or crystal growth inhibitors may function in different ways but the combination use of nucleation and crystal growth inhibitors in supersaturated system is rarely explored. Thus, using Lacidipine (LCDP) as a Biopharmaceutical Classification System (BCS) II model drug, the aim of this study was to explore whether the combination use of nucleation and crystal growth inhibitors could provide a synergistic effect on the in vitro-in vivo performance of poorly water-soluble drugs. First of all, based on compatibility screening using solubility parameter (Δδ) and crystallization inhibition efficiency as criteria, soluplus (SOL) and gum arabic (GA) were selected as the most effective nucleation and crystal growth inhibitor respectively. Thereafter, the supersaturated drug solutions were spray dried and characterized. The in vitro release, physical stability as well as pharmacokinetic behavior were investigated. It was found that the combination use of SOL and GA did not present remarkable advantage in prolonging the supersaturation time in solution state. However, their synergistic effect in equilibrium solubility and dissolution enhancement was noticed at SOL/GA ratio 3:1, with 5-7 times higher dissolution rate observed for LCDP/SOL/GA based formulation compared with that of LCDP/SOL, which was maintained even after three months accelerated stability test under non-sink condition. Moreover, compared to the LCDP/SOL formulation, approximately 2.8 and 2.5-fold increase in the maximum plasma concentration (Cmax) and the area under the plasma-time curve (AUC0-∞) was achieved with LCDP/SOL/GA based formulation. Possible mechanism of the synergistic effect was elucidated, indicating GA may penetrate into SOL particles providing both electrostatic and steric stabilization. In conclusion, the combination use of screened nucleation and crystal growth inhibitors might be an efficient approach to design supersaturated drug delivery system.


Assuntos
Di-Hidropiridinas , Goma Arábica , Polietilenoglicóis , Polivinil , Animais , Disponibilidade Biológica , Cristalização , Di-Hidropiridinas/administração & dosagem , Di-Hidropiridinas/química , Di-Hidropiridinas/farmacocinética , Liberação Controlada de Fármacos , Sinergismo Farmacológico , Goma Arábica/administração & dosagem , Goma Arábica/química , Goma Arábica/farmacocinética , Polietilenoglicóis/administração & dosagem , Polietilenoglicóis/química , Polietilenoglicóis/farmacocinética , Polivinil/administração & dosagem , Polivinil/química , Polivinil/farmacocinética , Ratos Sprague-Dawley
8.
Int J Pharm ; 565: 316-324, 2019 Jun 30.
Artigo em Inglês | MEDLINE | ID: mdl-31022504

RESUMO

Using tadalafil (TD) as a representative of heat-sensitive drug with high melting point and strong crystallization tendency, we observed that recrystallization of the prepared amorphous materials during extrusion can result in failure of amorphous solid dispersion (ASD) extrusion. Such recrystallization process of amorphous TD during reheating process was investigated systematically. Our results show that spray-dried amorphous TD sample is more prone to recrystallize (occurs from 150 °C) in comparison to the melt-quenched amorphous TD sample (recrystallizes from 190 °C). Poor stability of the spray-dried TD sample is likely due to an excessive amount of available surface area. Co-extruding Soluplus with spray-dried amorphous TD at 160 °C could yield ASD at 10% drug loading and crystalline solid dispersion above 20% drug loading. The method that spray drying 20% TD with 80% Soluplus and then extruding the spray-dried sample can obtain ASD at 20% drug loading at 160 °C, 142 °C lower than the melting point of TD (302 °C). More importantly, the samples prepared by such strategy exhibited a substantially improved bioavailability compared to the samples that were prepared by either spray-dried or hot-melt extruded processes.


Assuntos
Tadalafila/química , Tadalafila/farmacocinética , Animais , Disponibilidade Biológica , Cristalização , Dessecação , Composição de Medicamentos , Liberação Controlada de Fármacos , Estabilidade de Medicamentos , Temperatura Alta , Masculino , Inibidores da Fosfodiesterase 5/administração & dosagem , Inibidores da Fosfodiesterase 5/química , Polietilenoglicóis/administração & dosagem , Polietilenoglicóis/química , Polivinil/administração & dosagem , Polivinil/química , Ratos Sprague-Dawley , Temperatura de Transição
10.
Vasc Endovascular Surg ; 53(5): 415-419, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30929610

RESUMO

A 57-year-old male presented with intermittent gastrointestinal bleeding (GIB) 1 year after a successful simultaneous pancreas and kidney transplant. No source could be found after 5 tagged red blood cell studies, 3 computed tomographies (CTs), 7 endoscopies, and 4 catheter angiograms. Review of CTs showed pathologically enlarged superior mesenteric vein branches near a jejunal segment near pancreas graft. Transhepatic superior mesenteric venogram showed varicosities near jejunum, which were obliterated with ethylene vinyl alcohol (Onyx). Follow-up CTs confirmed complete obliteration, but he had more GIBs and eventually underwent native jejunal and donor duodenal resection. He has remained GIB-free for 12 months.


Assuntos
Embolização Terapêutica/métodos , Jejuno/irrigação sanguínea , Veias Mesentéricas , Transplante de Pâncreas/efeitos adversos , Polivinil/administração & dosagem , Tantálio/administração & dosagem , Varizes/terapia , Angiografia Digital , Biópsia , Endoscopia por Cápsula , Angiografia por Tomografia Computadorizada , Procedimentos Cirúrgicos do Sistema Digestório , Combinação de Medicamentos , Hemorragia Gastrointestinal/etiologia , Humanos , Transplante de Rim , Masculino , Veias Mesentéricas/diagnóstico por imagem , Pessoa de Meia-Idade , Flebografia/métodos , Recidiva , Resultado do Tratamento , Varizes/diagnóstico por imagem , Varizes/etiologia , Varizes/cirurgia
12.
World Neurosurg ; 126: 466, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30862592

RESUMO

Onyx (ethylene vinyl alcohol, ev3, Irvine, California, USA) is commonly used to treat dural arteriovenous fistulas (DAVFs) and presents several advantages over n-butyl cyanoacrylate glue (Codman Neurovascular Inc, Raynham, Massachusetts, USA) including slower, more controlled injections and better penetration via radial casting. However, Onyx is nonthrombogenic and may result in incomplete casting, recanalization, and DAVF recurrence. Here, we demonstrate glue embolization with guide catheter dextrose push of a recurrent DAVF previously embolized with Onyx. A 79-year-old female diagnosed with a Cognard IIA+B DAVF was successfully treated with transarterial Onyx injection. A 6-month follow-up angiogram, however, revealed recurrence of the DAVF with recanalization of the previously embolized draining vein. She subsequently underwent retreatment using glue embolization with a guide catheter dextrose push. Informed written consent was obtained. A Magic microcatheter (Balt Extrusion, Irvine, California, USA) was passed via a 6-French Envoy guide catheter (Codman Neurovascular) in the external carotid artery and was used to select the superficial temporal artery and then navigated distally through a transosseous connection into the dura. A dilute 12.5% concentration of glue was injected slowly and continuously and was seen to fill in spaces within the old Onyx material. Dextrose 5% in water was concomitantly injected through the guide catheter to ensure distal migration of the glue and occlusion of the draining vein. Glue embolization with dextrose push is a valuable treatment option for DAVF, especially in smaller recurrent feeders that can fill in the Onyx recanalized cast. The 6-month follow-up angiogram showed persistent occlusion of the dural fistula (Video 1).


Assuntos
Malformações Vasculares do Sistema Nervoso Central/terapia , Dimetil Sulfóxido/administração & dosagem , Embolização Terapêutica/instrumentação , Embolização Terapêutica/métodos , Polivinil/administração & dosagem , Adesivos/administração & dosagem , Idoso , Cateteres , Feminino , Glucose , Humanos , Resultado do Tratamento
13.
Cardiovasc Intervent Radiol ; 42(7): 956-961, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30847499

RESUMO

BACKGROUND: Twenty percent of the patients with AAA have an aneurysm involving the common iliac arteries. Large common iliac diameter can be treated with an iliac branched device or extension of the stent graft to the external iliac artery with occlusion of the ipsilateral internal iliac artery (IIA) to prevent type 2 endoleaks. This study describes and evaluates a embolization technique using Onyx in conjunction with EVAR in aneurysms with poor landing zones in the common iliac arteries. METHODS: Patients with Onyx IIA embolization during EVAR, identified from the hospital operating code database, constitute the study population. Onyx embolization was performed by injection at the IIA origin. Peri- and postoperative complications were collected from the medical records. Thin-sliced CT scan was performed 1 month and 1 year after the procedure. RESULTS: Thirty-six patients with complex iliac anatomy and insufficient landing zones (without sealing possibility for standard stent grafts) were identified out of 243 consecutive EVAR treatments during a 13-year period. In seventeen patients (7%), the IIA was embolized with Onyx. Technical success was obtained in all 17 patients, without adverse event or procedural complication. No complication related to the embolization procedure was noted during follow-up. CONCLUSIONS: During EVAR treatment of patients with aneurysm involving the common iliac artery, Onyx embolization of IIA is a feasible option without need of selective catheterization of the IIA orifice, potentially preserving important branches of the IIA and simplifying emergency procedures.


Assuntos
Aneurisma da Aorta Abdominal/complicações , Aneurisma da Aorta Abdominal/cirurgia , Embolização Terapêutica/métodos , Procedimentos Endovasculares/métodos , Aneurisma Ilíaco/complicações , Aneurisma Ilíaco/terapia , Idoso , Idoso de 80 Anos ou mais , Aneurisma da Aorta Abdominal/diagnóstico por imagem , Implante de Prótese Vascular/métodos , Combinação de Medicamentos , Feminino , Humanos , Aneurisma Ilíaco/diagnóstico por imagem , Artéria Ilíaca/anormalidades , Artéria Ilíaca/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Polivinil/administração & dosagem , Estudos Retrospectivos , Stents , Tantálio/administração & dosagem , Fatores de Tempo , Tomografia Computadorizada por Raios X , Resultado do Tratamento
17.
Neuroradiology ; 61(4): 471-478, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30712140

RESUMO

PURPOSE: Insufficient nidus occlusion is a matter of great concern to routine Onyx embolization of brain arteriovenous malformations (AVMs). This paper described an efficient method which using the diluted Onyx embolization technique to treat brain AVM. METHODS: The diluted Onyx technique was performed in a series of 15 patients with brain AVMs (10 males, 5 females; age range, 11-44 years). It consists of initial embolization with routine Onyx-18, followed by the diluted Onyx (1.5 mL of Onyx-18 diluted with 0.5 mL of DMSO) through the same microcatheter. The technical skills and angiographic and clinical outcomes were analyzed. RESULTS: A total of 15 embolization sessions were performed with diluted Onyx via 16 arterial feeders in these 15 patients. Each patient underwent one attempt of diluted Onyx through a single feeder except one patient. In this patient, the AVM was simultaneously embolized with diluted Onyx through double microcatheters which were placed in two feeders. When the length of reflux reached to 2 cm (or close to the determined length) and the embolic material could not move distally any more despite some rounds of "injection-reflux-waiting," regular Onyx 18 was changed to diluted Onyx. Antegrade flow of embolic material into the nidus was observed in 12 cases but failed in 3. An average of 90% (range 55-100%) estimated size reduction was achieved, and 6 AVMs were completely obliterated. No functionally relevant complications occurred. CONCLUSION: The diluted Onyx technique could be a useful adjunct to routine Onyx embolization which may offer more embolic material penetrating into the nidus of AVM, but additional work is needed to validate this technique.


Assuntos
Angiografia por Tomografia Computadorizada/métodos , Embolização Terapêutica/métodos , Malformações Arteriovenosas Intracranianas/diagnóstico por imagem , Malformações Arteriovenosas Intracranianas/terapia , Polivinil/uso terapêutico , Tantálio/uso terapêutico , Adolescente , Adulto , Angiografia Digital , Angiografia Cerebral , Criança , Combinação de Medicamentos , Feminino , Humanos , Masculino , Polivinil/administração & dosagem , Tantálio/administração & dosagem , Resultado do Tratamento , Viscosidade
19.
Interv Neuroradiol ; 25(2): 230-233, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30394841

RESUMO

The technique of direct intratumoral injection of permanent liquid agents has evolved significantly over the past few decades. The percutaneous direct puncture technique is being utilised more and more for embolisation of head and neck hypervascular lesions. We describe a case treated via the direct percutaneous transnasal (TN) puncture technique for embolisation of a sinonasal hypervascular tumour, performed in a 21-year-old male patient. Due to extensive vascularisation of the tumour, preoperative embolisation was requested by our otolaryngologist team in order to minimise intraoperative bleeding and reduce surgical morbidity. A primary attempt at trans-arterial embolisation through selective ophthalmic artery catheterisation was unsuccessful due to unfavourable anatomy. An extensive devascularisation of the nasal fossa lesion was obtained using a single injection of low-density polymeric embolic agent (SQUID®). Post-operative eradication was uneventful. Final histopathology exam revealed vascular tumour consistent with a rare sinonasal glomangiopericytoma. To our knowledge, this is the first reported case of a rare sinonasal glomangiopericytoma treated by direct TN injection, utilising the liquid polymer agent SQUID®.


Assuntos
Tumor Glômico/tratamento farmacológico , Hemangiopericitoma/tratamento farmacológico , Neoplasias Nasais/tratamento farmacológico , Polivinil/administração & dosagem , Angiografia Digital , Animais , Meios de Contraste , Endoscopia , Tumor Glômico/diagnóstico por imagem , Hemangiopericitoma/diagnóstico por imagem , Humanos , Injeções Intralesionais , Imagem por Ressonância Magnética , Masculino , Neoplasias Nasais/diagnóstico por imagem , Punções , Tomografia Computadorizada por Raios X , Adulto Jovem
20.
Br J Neurosurg ; 33(3): 328-331, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30450994

RESUMO

Objective: Intra-arterial embolization of jugular paragangliomas is an established endovascular technique. Intratumoral embolization by direct puncture has been proposed, prior to surgical treatment or radiosurgery to reduce the risk of cranial nerve deficits. Methods: We examined the technical aspects of two patients with jugular paragangliomas embolized with liquid embolic agent by direct puncture of the lesion, as sole treatment. Results: Two patients with jugular paragangliomas presented with lower cranial nerve deficits. The first patient showed an extended lesion (55-mm) and was treated with partial intra-arterial embolization plus direct puncture and injection of Squid 18 and a second staged embolization by direct puncture and filling of the remainder of the lesion. The second patient with a smaller jugular paraganglioma (33-mm) was treated by single embolization by direct puncture of the tumor and injection of Squid 12 and Squid 18 obtaining complete filling of the lesion. No procedural complications were observed. Both patients showed no residual and initial improvement of the neurological deficits. Conclusion: The intratumoral embolization by direct puncture of jugular paragangliomas, under accurate radiological control is a safe procedure, and complete exclusion of the lesion can be obtained in selected cases. A staged particle embolization of the lesion by direct puncture can be proposed for large lesions. Only further studies with larger series and long-term follow-up will be able to define, if this strategy can be curative avoiding additional surgical or radio-surgical treatment.


Assuntos
Embolização Terapêutica/métodos , Tumor do Glomo Jugular/terapia , Hemostáticos/administração & dosagem , Polivinil/administração & dosagem , Adulto , Idoso , Humanos , Injeções Intralesionais , Masculino , Punções , Resultado do Tratamento , Procedimentos Cirúrgicos Vasculares/métodos
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA