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1.
N Engl J Med ; 384(6): 512-520, 2021 02 11.
Artigo em Inglês | MEDLINE | ID: mdl-33567191

RESUMO

BACKGROUND: The tubulin polymerization and Src kinase signaling inhibitor tirbanibulin is being investigated as a topical treatment for actinic keratosis, a precursor of squamous-cell carcinoma. METHODS: In two identically designed double-blind trials, we randomly assigned, in a 1:1 ratio, adults with actinic keratoses on the face or scalp to receive either topical tirbanibulin or vehicle (placebo) ointment. The ointment was applied by the patients to a 25-cm2 contiguous area containing four to eight lesions once daily for 5 consecutive days. The primary outcome was the percentage of patients with a complete (100%) reduction in the number of lesions in the application area at day 57. The secondary outcome was the percentage of patients with a partial (≥75%) reduction in the number of lesions within the application area at day 57. The incidence of recurrence was evaluated at 1 year. Local reactions were scored with the use of 4-point scale (ranging from 0 [absent] to 3 [severe]). RESULTS: A total of 702 patients were enrolled in the two trials (351 patients per trial). Complete clearance in trial 1 occurred in 44% of the patients (77 of 175) in the tirbanibulin group and in 5% of those (8 of 176) in the vehicle group (difference, 40 percentage points; 95% confidence interval [CI], 32 to 47; P<0.001); in trial 2, the percentages were 54% (97 of 178 patients) and 13% (22 of 173), respectively (difference, 42 percentage points; 95% CI, 33 to 51; P<0.001). The percentages of patients with partial clearance were significantly higher in the tirbanibulin groups than in the vehicle groups. At 1 year, the estimated percentage of patients with recurrent lesions was 47% among patients who had had a complete response to tirbanibulin. The most common local reactions to tirbanibulin were erythema in 91% of the patients and flaking or scaling in 82%. Adverse events with tirbanibulin were application-site pain in 10% of the patients and pruritus in 9%, all of which resolved. CONCLUSIONS: In two identically designed trials, tirbanibulin 1% ointment applied once daily for 5 days was superior to vehicle for the treatment of actinic keratosis at 2 months but was associated with transient local reactions and recurrence of lesions at 1 year. Trials comparing tirbanibulin with conventional treatments and that have longer follow-up are needed to determine the effects of tirbanibulin therapy on actinic keratosis. (Funded by Athenex; ClinicalTrials.gov numbers, NCT03285477 and NCT03285490.).


Assuntos
Inibidores Enzimáticos/uso terapêutico , Ceratose Actínica/tratamento farmacológico , Administração Tópica , Idoso , Método Duplo-Cego , Inibidores Enzimáticos/efeitos adversos , Face/patologia , Feminino , Humanos , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Pomadas/uso terapêutico , Polimerização/efeitos dos fármacos , Couro Cabeludo/patologia , Pele/patologia , Tubulina (Proteína)/metabolismo
2.
Arq. bras. med. vet. zootec. (Online) ; 72(4): 1286-1294, July-Aug. 2020. tab, ilus
Artigo em Português | LILACS, VETINDEX | ID: biblio-1131465

RESUMO

Cicatrização de ferida é um processo dinâmico, que tem por objetivo restaurar a continuidade do tecido lesionado. No entanto, em alguns casos, é necessário favorecer condições adequadas para viabilizar o processo fisiológico. Neste estudo foram utilizados ratos Wistar, divididos aleatoriamente entre cinco grupos, com 12 animais cada, sendo eles: grupo P (Bidens pilosa L.), grupo mel, grupo Co1 (pomada comercial alopática), grupo Co2 (pomada comercial homeopática) e grupo CT (controle). As lesões foram geradas por incisão com punch de 8mm, sendo tratadas diariamente de forma tópica. Foram eutanasiados quatro animais por grupo, no terceiro, sétimo e 14º dias do experimento, e o material coletado foi armazenado em formalina 10% e encaminhado para processamento histológico. Posteriormente, realizou-se a contagem de leucócitos mononucleares, fibroblastos e neovasos e avaliou-se a arquitetura de fibras colágenas. Os resultados da contagem foram analisados pela ANOVA, seguida pelo teste de Tukey (P<0,05). O modelo experimental proposto neste estudo demonstrou que todos os tratamentos apresentaram potencial cicatrizante, com exceção do mel. A aplicação tópica do creme do extrato de Bidens pilosa L. a 10% apresentou melhor perfil anti-inflamatório; a pomada alopática apresentou boa aderência à superfície da lesão e a pomada homeopática, grande potencial angiogênico, com menor tempo de cicatrização.(AU)


Wound healing is a dynamic process that aims to restore the continuity of injured tissue. However, in some cases it is necessary to favor adequate conditions to enable the physiological process. Wistar rats were randomly divided into 5 groups with 12 animals each, namely: group P (Bidens pilosa L.), group honey, group Co1 (commercial allopathic ointment), group Co2 (commercial homeopathic ointment) and group CT (control). The lesions were generated by an 8mm punch incision and were treated topically daily. Four animals per group were euthanized on the 3rd, 7th and 14th day of the experiment and the collected material was stored in 10% formalin and sent for histological processing, after which mononuclear, fibroblasts and neovascular leukocytes were counted and collagen fiber architecture was evaluated. Counting results were analyzed by ANOVA, followed by Tukey test (p <0.05). The experimental model proposed in this study showed that all treatments had healing potential, except honey. The topical application of 10% Bidens pilosa L. extract cream showed the best anti-inflammatory profile; Allopathic ointment showed good adhesion to the surface of the lesion and homeopathic ointment showed great angiogenic potential with shorter healing time.(AU)


Assuntos
Animais , Ratos , Pomadas/uso terapêutico , Pele/lesões , Bidens/química , Mel , Cicatrização/efeitos dos fármacos , Ferimentos e Lesões/terapia , Medicamento Homeopático , Colágeno , Ratos Wistar/fisiologia , Medicamentos Fitoterápicos , Fibroblastos
3.
Clin Ter ; 171(4): e310-e315, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32614364

RESUMO

BACKGROUND: Psoriasis is a multifactorial chronic inflammatory skin disease characterized by erythemato-squamous lesions with a chronic relapsing course. The desease clinical activity (PASI) and the patient's quality of life (DLQI) are the main elements to assess for setting up a correct therapeutic management. OBJECTIVES: The aim of the study was to evaluate the management of the patient with moderate-severe psoriasis in therapy with biological drugs and to establish the difference in the achievement of PASI 90 and DLQI 0-1 between a group of patients treated with only biological drugs and a group of patients receiving biologic therapy in combination with a topical ointment. METHODS: We conducted a prospective, observational real-life study enrolling 60 patients with moderate to severe psoriasis and divided in two groups: Group A patients treated with biological drugs, Group B patiens treated with biological drugs in association with an ointment composed of betamethasone, salicylic acid and ammonium sulpho-ichtyolate, applied 2 times a day. PASI and DLQI were evaluated at study beginning (T0) for both study groups, after 12 weeks (T3) for sample in therapy with biological drugs and after 24 weeks (T6) for sample in co-medication therapy. RESULTS: The two-way ANOVA method was used to evaluate the standard deviations (SD): at T3 and T6 Group B obtained a significant PASI reduction and improvement of DLQI (* p value <0.05) compared to Group A. CONCLUSIONS: Our study shown that the patients treated with biologics in co-medication with topical therapy reached a significantly higher PASI and DQLI compared with those treated with only biologics. Furthermore we observed that the association with topical oinment showed more efficacy in the treatment of areas such as palm-plantar region, that is often difficult-to-treat region, even for biologic drugs.


Assuntos
Produtos Biológicos/uso terapêutico , Pomadas/uso terapêutico , Psoríase/tratamento farmacológico , Adulto , Doença Crônica , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Qualidade de Vida , Índice de Gravidade de Doença , Pele/patologia
4.
J Dairy Sci ; 103(8): 7339-7350, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32505405

RESUMO

Disbudding is a common procedure practiced in the dairy industry and is known to cause pain when performed without pain control. Dairy producers who disbud calves with caustic paste are less likely to provide pain control than those using cautery. Little research has been conducted on pain control for caustic paste disbudding and no studies have specifically examined calves under 9 d of age. The objective of this study was to evaluate the efficacy of local anesthesia and nonsteroidal anti-inflammatory drug analgesia on indicators of pain and inflammation in dairy calves disbudded using caustic paste. One hundred forty Holstein heifer calves 1 to 9 d of age were enrolled in 28 blocks and randomly allocated to 1 of 5 treatments: sham control (SH); positive control (POS); lidocaine cornual nerve block (LC); meloxicam (MEL); and lidocaine cornual nerve block plus meloxicam (LCM). We measured outcomes including serum cortisol and haptoglobin, pressure sensitivity, and lying behavior. Data were analyzed using mixed linear regression models with treatment as a fixed effect, baseline values as a covariate, and trial block as a random effect. Compared with the POS group, the LCM group had reduced serum cortisol at 15, 30, 45, and 60 min post-disbudding; cortisol values were not different between LC, LCM, and SH calves at these time points. At 60, 90, 120, and 180 min post-disbudding, LCM calves had reduced cortisol compared with LC calves, whereas, values did not differ between LCM and SH calves at these time points. At 3 to 4 d post-disbudding, the LCM group tended to have reduced haptoglobin, but no differences were found between groups at 180 min and 7 d post-disbudding. At 60, 90, and 120 min post-disbudding, LC and LCM treated calves had decreased pressure sensitivity compared with other groups. No differences were seen in pressure sensitivity between groups at 180 min, 3 to 4 or 7 d post-disbudding. No differences in lying behavior were found between treatment groups on any of the 7 d following disbudding. These findings demonstrate that the combination of a local anesthetic with a nonsteroidal anti-inflammatory drug is beneficial for reducing indicators of pain and inflammation in young calves disbudded with caustic paste.


Assuntos
Dor Aguda/veterinária , Anestésicos Locais/uso terapêutico , Bem-Estar do Animal , Anti-Inflamatórios não Esteroides/uso terapêutico , Doenças dos Bovinos/prevenção & controle , Cáusticos/uso terapêutico , Dor Aguda/prevenção & controle , Analgesia/veterinária , Anestesia Local/veterinária , Animais , Bovinos , Cauterização/efeitos adversos , Cauterização/veterinária , Indústria de Laticínios , Feminino , Cornos/cirurgia , Lidocaína/uso terapêutico , Meloxicam/administração & dosagem , Bloqueio Nervoso/veterinária , Pomadas/uso terapêutico
5.
Br J Hosp Med (Lond) ; 81(6): 1-10, 2020 Jun 02.
Artigo em Inglês | MEDLINE | ID: mdl-32589541

RESUMO

Ocular complications in critical care patients are common. There has been a surge in intensive care admissions following the COVID-19 outbreak. The management of COVID-19 exposes patients to a number of specific risk factors for developing ocular complications, which include non-invasive ventilation, mechanical ventilation and prone positioning. Consequently, it is likely that there will be an increase in the number of ocular complications secondary to the management of COVID-19 patients in the intensive care unit setting, and these complications could lead to permanent visual loss and blindness. Increased awareness of eye care in the intensive care unit setting is therefore vital to help prevent visual loss and maintain quality of life for patients recovering from COVID-19.


Assuntos
Infecções por Coronavirus/terapia , Oftalmopatias/terapia , Unidades de Terapia Intensiva , Oftalmologia , Pneumonia Viral/terapia , Encaminhamento e Consulta , Doença Aguda , Betacoronavirus , Doenças da Túnica Conjuntiva/prevenção & controle , Doenças da Túnica Conjuntiva/terapia , Conjuntivite/prevenção & controle , Conjuntivite/terapia , Doenças da Córnea/prevenção & controle , Doenças da Córnea/terapia , Lesões da Córnea/prevenção & controle , Lesões da Córnea/terapia , Cuidados Críticos , Estado Terminal , Edema/prevenção & controle , Edema/terapia , Endoftalmite/prevenção & controle , Endoftalmite/terapia , Oftalmopatias/prevenção & controle , Glaucoma/diagnóstico , Glaucoma/terapia , Humanos , Ceratite/prevenção & controle , Ceratite/terapia , Lubrificantes/uso terapêutico , Pomadas/uso terapêutico , Pandemias , Transtornos da Visão/diagnóstico , Transtornos da Visão/terapia
6.
Khirurgiia (Mosk) ; (5): 81-86, 2020.
Artigo em Russo | MEDLINE | ID: mdl-32500694

RESUMO

Increase of the frequency of soft tissues pyoinflammatory diseases and purulent-septic complications against the background the antibiotic-resistance of organism dictates the necessity of search of rational new surgical technologies and preparations with the intense bactericidal effect. Period of the connective tissue (cicatrix) formation on a place of wound defect of the operated purulent abscess of soft tissue (PAST) is defined by the speed of the granulations and epithelial tissue formation. Therefore, one of the task of experimental surgery is search of new methods of the effective postoperative influence on terms of the regeneration and complete obliteration of the PAST cavity. The perspective direction in treatment of surgical infection is application of metals nanoparticles. In treatment of pyoinflammatory processes it is applied the preparation Eplan and also zinc oxide nanoparticles which have bactericidal, antiinflammatory and regenerative effects. However, till now it was not carried out experimental works on modelling and surgical treatment of PAST with local application of the laser technologies in combinations with Eplan and metals nanoparticles.


Assuntos
Abscesso/terapia , Antibacterianos/uso terapêutico , Nanopartículas Metálicas/uso terapêutico , Infecções dos Tecidos Moles/terapia , Abscesso/tratamento farmacológico , Abscesso/cirurgia , Antibacterianos/administração & dosagem , Combinação de Medicamentos , Humanos , Terapia a Laser , Nanopartículas Metálicas/administração & dosagem , Pomadas/administração & dosagem , Pomadas/uso terapêutico , Infecções dos Tecidos Moles/tratamento farmacológico , Infecções dos Tecidos Moles/cirurgia , Supuração/tratamento farmacológico , Supuração/cirurgia , Supuração/terapia , Óxido de Zinco/administração & dosagem , Óxido de Zinco/uso terapêutico
7.
BMC Complement Med Ther ; 20(1): 146, 2020 May 13.
Artigo em Inglês | MEDLINE | ID: mdl-32404169

RESUMO

BACKGROUND: Acute radiation-induced proctitis (ARP) is the most common side effect following radiotherapy for malignant pelvic disease. This study evaluated the efficacy of Aloe vera ointment in prevention of ARP. METHODS: Forty-two patients receiving external-beam radiotherapy (RT) for pelvic malignancies were randomized to receive either Aloe vera 3% or placebo topical ointment during radiotherapy for 6 weeks. These patients were evaluated based on the severity (grade 0-4) of the following symptoms weekly: rectal bleeding, abdominal/rectal pain, diarrhea, or fecal urgency. RTOG acute toxicity criteria and psychosocial status of the patients were also recorded weekly. Lifestyle impact of the symptoms, and quantitative measurement of C-reactive protein (CRP), an indicator of systemic inflammation, were also measured. RESULTS: The results of present study demonstrated a significant preventive effect for Aloe vera in occurrence of symptom index for diarrhea (p < 0.001), rectal bleeding (p < 0.001), and fecal urgency (p = 0.001). The median lifestyle score improved significantly with Aloe vera during RT (p < 0.001). Intervention patients had a significant lower burden of systemic inflammation as the values for quantitative CRP decreased significantly over 6 weeks of follow-up (p = 0.009). CONCLUSION: This study showed that Aloe vera topical ointment was effective in prevention of symptoms of ARP in patients undergoing RT for pelvic cancers. TRIAL REGISTRATION: IRCT201606042027N6. Registration date: 2016-09-04.


Assuntos
Aloe , Neoplasias Pélvicas/radioterapia , Preparações de Plantas/uso terapêutico , Proctite/prevenção & controle , Lesões por Radiação/prevenção & controle , Idoso , Proteína C-Reativa/análise , Método Duplo-Cego , Feminino , Humanos , Irã (Geográfico) , Masculino , Pessoa de Meia-Idade , Pomadas/uso terapêutico , Estudos Prospectivos , Qualidade de Vida , Radioterapia/efeitos adversos , Inquéritos e Questionários
8.
J Ayub Med Coll Abbottabad ; 32(1): 152, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32468778

RESUMO

Eleven months old female patient presented to paediatric out patient with parents concerned about her facial swelling. Upon examination child's weight and height for age were normal on her percentiles, she had a cushingoid facies with plethoric cheeks (Figure-1,2) though generalized oedema was absent and there was centripetal obesity with some muscle wasting (Figure-3,4). Systemic examination was normal excluding blood pressure which was high for her age. Electrolytes and cortisol levels were normal. On further inquiry it was revealed that she had been using a nappy rash cream containing a potent steroid, i.e., fluticasone for 2 months and this was identified as a cause for her cushingoid features.


Assuntos
Síndrome de Cushing/induzido quimicamente , Hipertensão/induzido quimicamente , Creme para a Pele/efeitos adversos , Anti-Inflamatórios/efeitos adversos , Anti-Inflamatórios/uso terapêutico , Dermatite das Fraldas/tratamento farmacológico , Feminino , Fluticasona/efeitos adversos , Fluticasona/uso terapêutico , Humanos , Doença Iatrogênica , Lactente , Pomadas/efeitos adversos , Pomadas/química , Pomadas/uso terapêutico , Creme para a Pele/química , Creme para a Pele/uso terapêutico
9.
Enferm. clín. (Ed. impr.) ; 30(supl.3): 14-17, mar. 2020. graf, tab
Artigo em Inglês | IBECS | ID: ibc-196102

RESUMO

OBJECTIVES: This study aimed to compare the impact of honey and natural ointment based on honey-Tea Tree Oil. METHODS: This was a quasi-experimental study with a pre-post control group design approach. The sample consisted of 27 respondents in two different wound care clinics. The instruments used were the Leg Ulcer Measurement Tool (LUMT) measured on day 1, 7 and 14. Data was analyzed using paired t-test, pooled t-test, and multiple regression test. RESULTS: Most participants were female, the average age was 50.89 years, the average duration of illness for type II diabetes was 3.56 and had current infection. The results showed a significant difference in LUMT score between before and after treatment of wounds healing in the two intervention groups (p-value=0.000). CONCLUSION: Honey and natural ointment based on honey - tea tree oil significantly contributed to the healing of Diabetic Foot Ulcer


No disponible


Assuntos
Adulto , Pessoa de Meia-Idade , Idoso , Pé Diabético/terapia , Mel , Úlcera da Perna/terapia , Apiterapia , Cicatrização , Pomadas/uso terapêutico , Pé Diabético/enfermagem
10.
Cochrane Database Syst Rev ; 1: CD001836, 2020 01 20.
Artigo em Inglês | MEDLINE | ID: mdl-31978262

RESUMO

BACKGROUND: It is estimated that up to 1% of people in high-income countries suffer from a leg ulcer at some time in their life. The majority of leg ulcers are associated with circulation problems; poor blood return in the veins causes venous ulcers (around 70% of ulcers) and poor blood supply to the legs causes arterial ulcers (around 22% of ulcers). Treatment of arterial leg ulcers is directed towards correcting poor arterial blood supply, for example by correcting arterial blockages (either surgically or pharmaceutically). If the blood supply has been restored, these arterial ulcers can heal following principles of good wound-care. Dressings and topical agents make up a part of good wound-care for arterial ulcers, but there are many products available, and it is unclear what impact these have on ulcer healing. This is the third update of a review first published in 2003. OBJECTIVES: To determine whether topical agents and wound dressings affect healing in arterial ulcers. To compare healing rates and patient-centred outcomes between wound dressings and topical agents. SEARCH METHODS: The Cochrane Vascular Information Specialist searched the Cochrane Vascular Specialised Register, Cochrane Central Register of Controlled Trials, MEDLINE, Embase, Cumulative Index to Nursing and Allied Health Literature and Allied and Complementary Medicine databases, the World Health Organization International Clinical Trials Registry Platform and ClinicalTrials.gov trials register to 28 January 2019. SELECTION CRITERIA: Randomised controlled trials (RCTs), or controlled clinical trials (CCTs) evaluating dressings and topical agents in the treatment of arterial leg ulcers were eligible for inclusion. We included participants with arterial leg ulcers irrespective of method of diagnosis. Trials that included participants with mixed arterio-venous disease and diabetes were eligible for inclusion if they presented results separately for the different groups. All wound dressings and topical agents were eligible for inclusion in this review. We excluded trials which did not report on at least one of the primary outcomes (time to healing, proportion completely healed, or change in ulcer area). DATA COLLECTION AND ANALYSIS: Two review authors independently extracted information on the participants' characteristics, the interventions, and outcomes using a standardised data extraction form. Review authors resolved any disagreements through discussion. We presented the data narratively due to differences in the included trials. We used GRADE to assess the certainty of the evidence. MAIN RESULTS: Two trials met the inclusion criteria. One compared 2% ketanserin ointment in polyethylene glycol (PEG) with PEG alone, used twice a day by 40 participants with arterial leg ulcers, for eight weeks or until healing, whichever was sooner. One compared topical application of blood-derived concentrated growth factor (CGF) with standard dressing (polyurethane film or foam); both applied weekly for six weeks by 61 participants with non-healing ulcers (venous, diabetic arterial, neuropathic, traumatic, or vasculitic). Both trials were small, reported results inadequately, and were of low methodological quality. Short follow-up times (six and eight weeks) meant it would be difficult to capture sufficient healing events to allow us to make comparisons between treatments. One trial demonstrated accelerated wound healing in the ketanserin group compared with the control group. In the trial that compared CGF with standard dressings, the number of participants with diabetic arterial ulcers were only reported in the CGF group (9/31), and the number of participants with diabetic arterial ulcers and their data were not reported separately for the standard dressing group. In the CGF group, 66.6% (6/9) of diabetic arterial ulcers showed more than a 50% decrease in ulcer size compared to 6.7% (2/30) of non-healing ulcers treated with standard dressing. We assessed this as very-low certainty evidence due to the small number of studies and arterial ulcer participants, inadequate reporting of methodology and data, and short follow-up period. Only one trial reported side effects (complications), stating that no participant experienced these during follow-up (six weeks, low-certainty evidence). It should also be noted that ketanserin is not licensed in all countries for use in humans. Neither study reported time to ulcer healing, patient satisfaction or quality of life. AUTHORS' CONCLUSIONS: There is insufficient evidence to determine whether the choice of topical agent or dressing affects the healing of arterial leg ulcers.


Assuntos
Úlcera da Perna/terapia , Pomadas/uso terapêutico , Cicatrização , Administração Tópica , Artérias , Curativos Hidrocoloides , Humanos , Curativos Oclusivos , Ensaios Clínicos Controlados Aleatórios como Assunto , Úlcera Varicosa/terapia
11.
Mater Sci Eng C Mater Biol Appl ; 106: 110056, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31753372

RESUMO

Proanthocyanidins (PCs), a component of grape seed extract (GSE), have recently being used for the treatment of wounds. However, poor absorption, poor stability and rapid elimination from the systemic circulation limit its acceptance. In addressing these problems, we herein report the development of PCs based nanoformulations (PCs/SOLU) for the first time based on 1% GSE and assessed its wound healing potential in-vivo on the wistar rats. GSE and PCs/SOLU nanodispersions 1% were prepared by incorporating them into the ointment base via uniform mixing to form ointment which could be easily applied topically to wounds. The antibacterial activity of PCs/SOLU against gram positive and gram-negative bacteria strains proved that the cell membranes became more permeable with disrupted cell structure. While carrageenan and histamine induced rat paw edema analyses show there was no inflammatory signs in animals treated with 1 wt% of PCs/SOLU nanodispersion. Excision wound measuring about 3 cm in depth was created on the wistar rats. The ointment was applied topically on the wounded site and the wound contraction was measured daily. Grape seed extract (GSE) ointment, ointment base and povidone­iodine (Povi-Iod) ointment of about 1% was used as the control, positive and negative standards. PCs/SOLU nanodispersion heals the wound by mobilising the fibroblasts in the wound site and inhibits the inflammatory response through decreased expression of monocyte. The macroscopical, immunological and histopathological assessments revealed that PCs/SOLU nanodispersion ointment usage improves the cell adhesion and proliferation.


Assuntos
Nanoestruturas/química , Pomadas/farmacologia , Proantocianidinas/química , Cicatrização/efeitos dos fármacos , Administração Tópica , Animais , Edema/induzido quimicamente , Edema/tratamento farmacológico , Edema/patologia , Eritrócitos/citologia , Eritrócitos/efeitos dos fármacos , Eritrócitos/metabolismo , Feminino , Bactérias Gram-Negativas/efeitos dos fármacos , Bactérias Gram-Positivas/efeitos dos fármacos , Extrato de Sementes de Uva/química , Hemólise/efeitos dos fármacos , Humanos , Masculino , Pomadas/química , Pomadas/uso terapêutico , Polietilenoglicóis/química , Polivinil/química , Proantocianidinas/farmacologia , Proantocianidinas/uso terapêutico , Ratos , Ratos Wistar , Pele/patologia
12.
Prensa méd. argent ; 105(9 especial): 521-525, oct 2019. tab
Artigo em Inglês | LILACS, BINACIS | ID: biblio-1046371

RESUMO

Over the last decade, the interest in using bacterial cellulose in medicine has increased. The article publishes the data about the efficiency of healing burn wounds in rabbits in experimental conditions with the use of the DermaRM wound dressing, compared to the traditionally used Panthenol ointment and the Branolind N salve dressing


Assuntos
Animais , Coelhos , Pomadas/uso terapêutico , Bandagens , Queimaduras/terapia , Celulose/uso terapêutico , Resultado do Tratamento , Tempo para o Tratamento
13.
Prensa méd. argent ; 105(9 especial): 652-659, oct 2019.
Artigo em Inglês | LILACS, BINACIS | ID: biblio-1046890

RESUMO

Cheilitis is a group of chronic diseases of the vermilion border that are diverse in etiology, pathogenesis and clinical picture. The development of various forms of cheilitis is facilitated by defects of the architectonics of the lips, unhealthy lifestyle, anatomical features of the lip structure, adverse meteorological effects, decrease in specific and non-specific factors for protecting the oral cavity, the patient's psycho-emotional state, immuno-allergic factors and accompanying general somatic and dental pathologies. The issues of prevention and comprehensive treatment of lip diseases are especially relevant in dental practice. The article presents data on the prevalence of cheilitis and dentoalveolar anomalies and the need for their treatment in young people. Furthermore, the authors provide a composition justification and develop an ointment for the treatment of cheilitis in this category of patients.


Assuntos
Humanos , Adolescente , Pomadas/uso terapêutico , Queilite/prevenção & controle , Queilite/terapia , Doenças Labiais/tratamento farmacológico
14.
Chem Pharm Bull (Tokyo) ; 67(9): 929-934, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31474731

RESUMO

We investigated the water contents in commercial semi-solid preparations used for pressure ulcer (PU) treatment using near-IR spectroscopy (NIRS) and compared the results with those measured using the Karl Fischer (KF) method. The aim of this study was to determine a standard method and select the appropriate topical preparation with the optimal moisture for PU treatment. The water absorption properties of bases and formulations were evaluated with a time-dependent factor using Transwell as the model membrane. KF and NIRS were applicable as measurement methods of the water content in semi-solid formulations. NIRS was shown to be a useful, simple, nondestructive tool that is more advantageous than the KF method. The water absorption characteristics tested using Transwell revealed that the rate of and capacity for water absorption are determined not only by the absorption ability of the polymer base but also by other factors, such as the osmotic pressure exerted by additives. KF and NIR measurements can be used to choose external skin preparations to control the amount of water in PU treatment.


Assuntos
Composição de Medicamentos/métodos , Água/química , Administração Tópica , Glicerol/química , Humanos , Pomadas/química , Pomadas/uso terapêutico , Polietilenoglicóis/química , Lesão por Pressão/tratamento farmacológico , Espectroscopia de Luz Próxima ao Infravermelho
15.
Endodoncia (Madr.) ; 37(2): 30-38, sept. 2019. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-186297

RESUMO

Objetivo: El objetivo de este estudio ha sido valorar cómo el hidróxido de calcio y la pasta triantibiótica (3-ATB) con agua destilada o propilenglicol actúan frente a una de las principales bacterias anaerobias facultativas presentes en dientes permanentes jóvenes con pulpa necrótica. Material y Método: Se llevó a cabo la siembra de la cepa bacteriana E.Coli (ATCC(R) 25922) en placas Petri para probar la susceptibilidad de los materiales mediante el método de difusión en agar. Se realizó la lectura de los resultados a las 48 horas mediante la medición de los halos de inhibición (mm) presentes en las placas. Resultados: La pasta tri-antibiótica mostró mayor inhibición que el hidróxido de calcio. Respecto a los solventes, la pasta 3-ATB ofreció mejor resultado combinada con propilenglicol, mientras que la respuesta del hidróxido de calcio fue más favorable al mezclar con agua destilada. Conclusiones: La pasta 3-ATB es más efectiva contra microorganismos anaerobios facultativos que el hidróxido de calcio, independientemente del solvente utilizado. En cuanto al solvente, el propilenglicol es más efectivo con pasta tri-antibiótica y el hidróxido de calcio lo es con agua destilada


Objective: The objective of this study was to assess how calcium hydroxide and triple antibiotic paste (3-ATB) with distilled water or propylene glycol act against one of the main facultative anaerobic bacteria present in young permanent teeth with necoritc pulp. Material and Methods: The seeding of the E.Coli (ATCC(R) 25922) was carried out in Petri dishes to test the susceptibility of the materials by the agar diffusion method. The results were read at 48 hours by measuring the inhibition zones (mm) present in the plates. Results: 3-ATB paste showed greater inhibition than calcium hydroxide. Regarding the solvents, 3-ATB paste offered better re-sults with propylene glycol, while the calcium hydroxide response was more favorable mixed with distilled water. Conclusions: 3-ATB paste is more effective against facultative anaerobic microorganisms than calcium hydroxide, regardless of the solvent used. As for the solvent, propylene glycol is more effective with 3-ATB paste while calcium hydroxide with distilled water


Assuntos
Humanos , Anti-Infecciosos/uso terapêutico , Hidróxido de Cálcio/metabolismo , Pomadas/uso terapêutico , Bactérias Anaeróbias/efeitos dos fármacos , Dentição Permanente , Propilenoglicol/uso terapêutico , Água Destilada , Espectrofotometria , Análise de Variância , Análise Estatística
16.
Med Arch ; 73(2): 131-133, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-31391704

RESUMO

Introduction: Diabetic foot ulcer (DFU) is a common lower-extremity complication in patients with diabetes mellitus. A novel DFU treatment is tested by using an ointment containing as healing agent olive oil isopod Ceratothoa oestroidesextract. Case report: A 58 years old obese man,smoker, with a history of unregulated Type 2 Diabetes Mellitus, peripheral neuropathy and Hodgkin lymphoma was referred to Athens-Greece university hospital Laikon. The patient presented clinically with a lower extremity DFU and peripheral neuropathy with dysesthesia and disturbed sensation of hot and cold. He was treated with an ointment containing C. oestroides extract for five months, without any antimicrobial treatment. Therapy was evaluated by measurement of the transepidermal water loss, skin hydration, photo documentation and planimetry. At each patient's visit, DFU presented a satisfactory healing process. Five months after treatment initiation the patient had complete healing of his DFU. Blood tests after treatment revealed a significant reduction of the levels of the inflammatory markers. Ulcer cultures did not reveal any microbial development neither before nor after treatment. Conclusion: The administration of the C. oestroides extract ointment proved to be effective in this case. Although these results should be further investigated, the reported case suggests a novel option for the management of neuropathic diabetic foot ulcers, especially in patients with severe co-morbidities.


Assuntos
Pé Diabético/terapia , Isópodes , Pomadas/uso terapêutico , Extratos de Tecidos/uso terapêutico , Animais , Diabetes Mellitus Tipo 2/complicações , Pé Diabético/complicações , Pé Diabético/imunologia , Neuropatias Diabéticas/complicações , Doença de Hodgkin/complicações , Humanos , Hospedeiro Imunocomprometido , Masculino , Pessoa de Meia-Idade , Obesidade/complicações , Fumar , Resultado do Tratamento , Cicatrização
17.
Dermatol Ther ; 32(5): e13047, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31369180

RESUMO

Dialkylcarbamoylchloride (DACC)-coated cotton acetate dressing works directly through hydrophobic interaction to reduce the number of bacteria without the risk of resistance. It is easy to use and therefore expected to improve patient's compliance. This study aimed to assess the clinical efficacy of DACC-coated cotton acetate dressing compared to a combination of normal saline dressing and 2% mupirocin ointment. A single-blind controlled trial was conducted and included 14 infected epidermolysis bullosa (EB) wounds which were divided into two groups. Group I received DACC-coated cotton acetate dressing, and Group II received the combination of normal saline dressing and 2% mupirocin ointment. Study results showed that the average time required for complete wound closure was 8.6 and 11.1 days in Groups I and II, respectively (p = .014), which was statistically significant. Both groups showed complete bacterial elimination on Day 3 based on negative Gram stain results and on Day 6 based on clearance of clinical manifestations (p = 1.000). This is a novel study in EB-infected wounds, which shows that DACC-coated cotton acetate dressing promotes faster wound closure and is as effective as the combination of normal saline dressing and 2% mupirocin ointment in eliminating bacterial infection.


Assuntos
Acetatos/uso terapêutico , Anti-Infecciosos Locais/uso terapêutico , Epidermólise Bolhosa/complicações , Mupirocina/uso terapêutico , Curativos Oclusivos , Infecção dos Ferimentos/terapia , Administração Tópica , Adolescente , Adulto , Criança , Quimioterapia Combinada , Epidermólise Bolhosa/diagnóstico , Feminino , Humanos , Masculino , Pomadas/uso terapêutico , Medição de Risco , Solução Salina/farmacologia , Método Simples-Cego , Cicatrização/efeitos dos fármacos , Cicatrização/fisiologia , Infecção dos Ferimentos/etiologia , Adulto Jovem
18.
J Complement Integr Med ; 16(4)2019 Aug 21.
Artigo em Inglês | MEDLINE | ID: mdl-31433782

RESUMO

Introduction Due to the effects of hemorrhoids on physical and mental health, this study aimed to compare the effect of Myrtus communis herbal and anti-hemorrhoid ointments on symptoms of hemorrhoid and quality of life (primary outcomes) and satisfaction of the treatment and side effects (secondary outcomes). Methods This triple-blind randomized controlled trial was performed on women with grade I and II hemorrhoid referring to health centers in Tehran, Iran, in 2017. Individuals were randomly assigned to two groups of 67 people through block randomization method. The intervention group received the Myrtus communis herbal ointment and the control group received anti-hemorrhoid ointment twice a day, every 12 ± 2 h, an applicator of the drug through the rectum for 4 weeks. The Colorectal Evaluation of a Clinical Therapeutics Scale (CORECTS) was used to assess the severity of symptoms of hemorrhoid. To assess the quality of life, the World Health Organization Quality of Life questionnaire (WHOQOL-BREF) was used to measure the general quality of life of participants. This questionnaire was completed once before the start of the study, then on the fourth and the eighth week after the start of the intervention. Repeated measure ANOVA, Chi-square, Mann-Whitney U and independent t-test were used for data analysis. Results The severity of all symptoms of hemorrhoid decreased in both two group and there was no statistically significant difference between the two groups (p>0.05). However, the mean of anal itching at 4 and 8 weeks after the intervention was significantly lower in the Myrtus communis ointment group (p<0.05). There was no significant difference between groups in terms of quality of life at 4 and 8 weeks after the intervention (p>0.05). There was a significant difference between the two groups in terms of satisfaction with the drug (p=0.019) and the participants in the Myrtus communis ointment group were more satisfied with their drug use. Conclusions Myrtus communis herbal ointment was able to reduce the symptoms of hemorrhoid in the affected women. Therefore, it is likely that the use of this drug will promote the health of mothers with hemorrhoid.


Assuntos
Hemorroidas/tratamento farmacológico , Myrtus/química , Óleos Voláteis/uso terapêutico , Fitoterapia , Período Pós-Parto , Acetatos/uso terapêutico , Adulto , Bicarbonatos/uso terapêutico , Quimioterapia Combinada , Feminino , Humanos , Hidrocortisona/análogos & derivados , Hidrocortisona/uso terapêutico , Irã (Geográfico) , Lidocaína/uso terapêutico , Pomadas/uso terapêutico , Medição da Dor , Qualidade de Vida , Supositórios/uso terapêutico , Inquéritos e Questionários
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