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1.
PLoS One ; 16(12): e0261637, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34928999

RESUMO

Auditory-evoked responses can be affected by the sound presented to the contralateral ear. The different contra-sound effects between noise and music stimuli on N1m responses of auditory-evoked fields and those on psychophysical response were examined in 12 and 15 subjects, respectively. In the magnetoencephalographic study, the stimulus to elicit the N1m response was a tone burst of 500 ms duration at a frequency of 250 Hz, presented at a level of 70 dB, and white noise filtered with high-pass filter at 2000 Hz and music stimuli filtered with high-pass filter at 2000 Hz were used as contralateral noise. The contralateral stimuli (noise or music) were presented in 10 dB steps from 80 dB to 30 dB. Subjects were instructed to focus their attention to the left ear and to press the response button each time they heard burst stimuli presented to the left ear. In the psychophysical study, the effects of contralateral sound presentation on the response time for detection of the probe sound of a 250 Hz tone burst presented at a level of 70 dB were examined for the same contra-noise and contra-music used in the magnetoencephalographic study. The amplitude reduction and latency delay of N1m caused by contra-music stimuli were significantly larger than those by contra-noise stimuli in bilateral hemisphere, even for low level of contra-music near the psychophysical threshold. Moreover, this larger suppressive effect induced by contra-music effects was also observed psychophysically; i.e., the change in response time for detection of the probe sound was significantly longer by adding contralateral music stimuli than by adding contra-noise stimuli. Regarding differences in effect between contra-music and contra-noise, differences in the degree of saliency may be responsible for their different abilities to disturb auditory attention to the probe sound, but further investigation is required to confirm this hypothesis.


Assuntos
Percepção Auditiva/fisiologia , Música , Ruído , Estimulação Acústica , Adulto , Encéfalo/diagnóstico por imagem , Encéfalo/fisiologia , Potenciais Evocados Auditivos/fisiologia , Feminino , Humanos , Imageamento por Ressonância Magnética , Magnetoencefalografia , Masculino , Música/psicologia , Neuroimagem , Psicofisiologia
2.
PLoS One ; 16(12): e0261295, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34898654

RESUMO

OBJECTIVES: The relationship between electrode-nerve interface (ENI) estimates and inter-subject differences in speech performance with sequential and simultaneous channel stimulation in adult cochlear implant listeners were explored. We investigated the hypothesis that individuals with good ENIs would perform better with simultaneous compared to sequential channel stimulation speech processing strategies than those estimated to have poor ENIs. METHODS: Fourteen postlingually deaf implanted cochlear implant users participated in the study. Speech understanding was assessed with a sentence test at signal-to-noise ratios that resulted in 50% performance for each user with the baseline strategy F120 Sequential. Two simultaneous stimulation strategies with either two (Paired) or three sets of virtual channels (Triplet) were tested at the same signal-to-noise ratio. ENI measures were estimated through: (I) voltage spread with electrical field imaging, (II) behavioral detection thresholds with focused stimulation, and (III) slope (IPG slope effect) and 50%-point differences (dB offset effect) of amplitude growth functions from electrically evoked compound action potentials with two interphase gaps. RESULTS: A significant effect of strategy on speech understanding performance was found, with Triplets showing a trend towards worse speech understanding performance than sequential stimulation. Focused thresholds correlated positively with the difference required to reach most comfortable level (MCL) between Sequential and Triplet strategies, an indirect measure of channel interaction. A significant offset effect (difference in dB between 50%-point for higher eCAP growth function slopes with two IPGs) was observed. No significant correlation was observed between the slopes for the two IPGs tested. None of the measures used in this study correlated with the differences in speech understanding scores between strategies. CONCLUSIONS: The ENI measure based on behavioral focused thresholds could explain some of the difference in MCLs, but none of the ENI measures could explain the decrease in speech understanding with increasing pairs of simultaneously stimulated electrodes in processing strategies.


Assuntos
Percepção Auditiva/fisiologia , Potenciais Evocados Auditivos/fisiologia , Percepção da Fala/fisiologia , Potenciais de Ação/fisiologia , Adulto , Idoso , Limiar Auditivo/fisiologia , Implante Coclear/métodos , Implantes Cocleares , Nervo Coclear/fisiologia , Estimulação Elétrica , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Fala/fisiologia
3.
J Am Acad Audiol ; 32(6): 379-385, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-34731905

RESUMO

BACKGROUND: Neurological, structural, and behavioral abnormalities are widely reported in individuals with autism spectrum disorder (ASD); yet there are no objective markers to date. We postulated that by using dominant and nondominant ear data, underlying differences in auditory evoked potentials (AEPs) between ASD and control groups can be recognized. PURPOSE: The primary purpose was to identify if significant differences exist in AEPs recorded from dominant and nondominant ear stimulation in (1) children with ASD and their matched controls, (2) adults with ASD and their matched controls, and (3) a combined child and adult ASD group and control group. The secondary purpose was to explore the association between the significant findings of this study with those obtained in our previous study that evaluated the effects of auditory training on AEPs in individuals with ASD. RESEARCH DESIGN: Factorial analysis of variance with interaction was performed. STUDY SAMPLE: Forty subjects with normal hearing between the ages of 9 and 25 years were included. Eleven children and 9 adults with ASD were age- and gender-matched with neurotypical peers. DATA COLLECTION AND ANALYSIS: Auditory brainstem responses (ABRs) and auditory late responses (ALRs) were recorded. Adult and child ASD subjects were compared with non-ASD adult and child control subjects, respectively. The combined child and adult ASD group was compared with the combined child and adult control group. RESULTS: No significant differences in ABR latency or amplitude were observed between ASD and control groups. ALR N1 amplitude in the dominant ear was significantly smaller for the ASD adult group compared with their control group. Combined child and adult data showed significantly smaller amplitude for ALR N1 and longer ALR P2 latency in the dominant ear for the ASD group compared with the control group. In our earlier study, the top predictor of behavioral improvement following auditory training was ALR N1 amplitude in the dominant ear. Correspondingly, the ALR N1 amplitude in the dominant ear yielded group differences in the current study. CONCLUSIONS: ALR peak N1 amplitude is proposed as the most feasible AEP marker in the evaluation of ASD.


Assuntos
Transtorno do Espectro Autista , Estimulação Acústica , Adolescente , Adulto , Criança , Potenciais Evocados Auditivos , Potenciais Evocados Auditivos do Tronco Encefálico , Humanos , Adulto Jovem
4.
Sensors (Basel) ; 21(20)2021 Oct 14.
Artigo em Inglês | MEDLINE | ID: mdl-34696039

RESUMO

Current developments towards multipin, dry electrodes in electroencephalography (EEG) are promising for applications in non-laboratory environments. Dry electrodes do not require the application of conductive gel, which mostly confines the use of gel EEG systems to the laboratory environment. The aim of this study is to validate soft, multipin, dry EEG electrodes by comparing their performance to conventional gel EEG electrodes. Fifteen healthy volunteers performed three tasks, with a 32-channel gel EEG system and a 32-channel dry EEG system: the 40 Hz Auditory Steady-State Response (ASSR), the checkerboard paradigm, and an eyes open/closed task. Within-subject analyses were performed to compare the signal quality in the time, frequency, and spatial domains. The results showed strong similarities between the two systems in the time and frequency domains, with strong correlations of the visual (ρ = 0.89) and auditory evoked potential (ρ = 0.81), and moderate to strong correlations for the alpha band during eye closure (ρ = 0.81-0.86) and the 40 Hz-ASSR power (ρ = 0.66-0.72), respectively. However, delta and theta band power was significantly increased, and the signal-to-noise ratio was significantly decreased for the dry EEG system. Topographical distributions were comparable for both systems. Moreover, the application time of the dry EEG system was significantly shorter (8 min). It can be concluded that the soft, multipin dry EEG system can be used in brain activity research with similar accuracy as conventional gel electrodes.


Assuntos
Eletroencefalografia , Potenciais Evocados Auditivos , Encéfalo , Eletrodos , Humanos , Razão Sinal-Ruído
5.
J Int Adv Otol ; 17(5): 400-404, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34617889

RESUMO

OBJECTIVES: This study investigated the development of aided long-latency response (ALLR) in children with cochlear implants (CI) within 18 months of implantation. MATERIALS AND METHODS: ALLR was recorded in 33 children with CI who had an experience of less than 18 months with the implant. All the participants were in the age range of 3-7 years and were divided into 3 groups based on implant age, as 0-6 months, 6.1-12 months, and 12.1-18 months. Latency of the P1 component was recorded. RESULTS: P1 latency was observed to be 142.105 ms at 0-6 months of implant age, 135.141 ms at 6.1-12 months of implant age, and 122.952 ms. at 12.1-18 months of implantation. CI recipients require 1 year of experience in order to obtain a significant difference in the P1 latency value. It was also found that gender does not influence P1 latency. CONCLUSION: These preliminary findings suggest that with adequate stimulation, there is a gradual decrease in P1 latency, which indicates maturation of the central auditory structures. It was also found that the gender does not influence P1 latency.


Assuntos
Implante Coclear , Implantes Cocleares , Surdez , Idoso de 80 Anos ou mais , Criança , Surdez/cirurgia , Potenciais Evocados Auditivos , Humanos , Lactente , Tempo de Reação
6.
Artigo em Chinês | MEDLINE | ID: mdl-34666442

RESUMO

Objective: To investigate the variation regularity and influencing factors of cortical auditory evoked potential (CAEP) evoked by pure tone, syllable and tone stimuli in cochlear implant (CI) children. Methods: Cortical auditory evoked potential (CAEP) responses were collected from 46 CI children in the sound field. Pure tones with frequencies of 1 kHz and 2 kHz were used as the standard and the deviant respectively in the pure tone stimulation condition. The Chinese Mandarin tokens/ba/-/pa/and/ba1/-/ba4/pairs were used as the stimuli respectively in the syllable and tone stimulation condition. The latency, amplitude and presence rate of P1 and mismatch negative(MMN) were obtained and the correlation between the difficulty of auditory task, the age of hearing month, the duration of severe-profound hearing loss, the wearing history of hearing aid before CI, the hearing threshold of the better ear before CI and the latency and amplitude of P1 and MMN were analyzed. All statistical analyses and figures were conducted using SPSS 25.0. Results: The P1 presence rate of pure tone, syllable and tone group was 100% (17/17), 100% (13/13) and 75.0% (12/16), respectively, with significant difference (χ²=8.214, P=0.016). There was significant difference between pure tone group and tone group (χ²=4.836, P=0.028), but no significant difference between pure tone group and syllable group, syllable group and tone group. The MMN presence rate of pure tone, syllable and tone group was 94.1% (16/17), 84.6% (11/13) and 62.5% (10/16), respectively, but no significant difference among the three groups with different auditory tasks(χ²=0.066, P=0.066). No significant difference was observed among the three groups of different auditory tasks in the latency and amplitude of P1 and MMN. Multiple linear regression analysis showed that the latency of P1 was positively correlated with the difficulty of auditory task and the hearing threshold of the better ear before CI, and negatively correlated with hearing age and the history of hearing aid before CI. The latency of MMN was positively correlated with the difficulty of auditory task, and negatively correlated with hearing age. Conclusions: The P1 presence rate of pure tone auditory task is significantly higher than that of tone auditory task. The difficulty of auditory task, hearing age, the history of hearing aid before CI, and the hearing threshold of the better ear before CI has significant effects on the P1 latency. The difficulty of auditory task and hearing age has significant effects on the MMN latency.


Assuntos
Implante Coclear , Implantes Cocleares , Auxiliares de Audição , Estimulação Acústica , Criança , Potenciais Evocados Auditivos , Audição , Humanos
7.
Clinics (Sao Paulo) ; 76: e2944, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34669874

RESUMO

OBJECTIVES: To analyze central auditory maturation in term and preterm infants during the first 3 months of life by comparing the latency and amplitude of cortical auditory-evoked potential at different frequencies. METHODS: In this study, 17 term and 18 preterm infants were examined; all had tested positive on the neonatal hearing screening test. Cortical auditory potential was investigated during the first and third months of life. The response of the cortical auditory-evoked potential was investigated at frequencies of 500, 1000, 2000, and 4000 Hz. The latency and amplitude of the cortical response were automatically detected and manually analyzed by three researchers with experience in electrophysiology. The results were compared using analysis of variance and the Bonferroni test. A significance level of 5% was used for all analyses. RESULTS: Latency values of cortical auditory-evoked potential in the first month of birth were significantly higher than those in the third month, and latency values of the preterm group were higher than those of the term group, regardless of the frequency and time of evaluation. In general, the latency of the cortical auditory-evoked potential was higher at high frequencies. Amplitude values in the third month of life were significantly higher than those in the first month for term and preterm infants. CONCLUSION: Central auditory maturation was observed in both groups but with different results between those born at term and preterm, with latencies of cortical auditory-evoked potential higher for the preterm group and at high frequencies.


Assuntos
Potenciais Evocados Auditivos do Tronco Encefálico , Recém-Nascido Prematuro , Biomarcadores , Potenciais Evocados Auditivos , Humanos , Lactente , Recém-Nascido , Triagem Neonatal
8.
J Neurodev Disord ; 13(1): 34, 2021 09 15.
Artigo em Inglês | MEDLINE | ID: mdl-34525943

RESUMO

This paper reviews a candidate biomarker for ASD, the M50 auditory evoked response component, detected by magnetoencephalography (MEG) and presents a position on the roles and opportunities for such a biomarker, as well as converging evidence from allied imaging techniques (magnetic resonance imaging, MRI and spectroscopy, MRS). Data is presented on prolonged M50 latencies in ASD as well as extension to include children with ASD with significant language and cognitive impairments in whom M50 latency delays are exacerbated. Modeling of the M50 latency by consideration of the properties of auditory pathway white matter is shown to be successful in typical development but challenged by heterogeneity in ASD; this, however, is capitalized upon to identify a distinct subpopulation of children with ASD whose M50 latencies lie well outside the range of values predictable from the typically developing model. Interestingly, this subpopulation is characterized by low levels of the inhibitory neurotransmitter GABA. Following from this, we discuss a potential use of the M50 latency in indicating "target engagement" acutely with administration of a GABA-B agonist, potentially distinguishing "responders" from "non-responders" with the implication of optimizing inclusion for clinical trials of such agents. Implications for future application, including potential evaluation of infants with genetic risk factors, are discussed. As such, the broad scope of potential of a representative candidate biological marker, the M50 latency, is introduced along with potential future applications.This paper outlines a strategy for understanding brain dysfunction in individuals with intellectual and developmental disabilities (IDD). It is proposed that a multimodal approach (collection of brain structure, chemistry, and neuronal functional data) will identify IDD subpopulations who share a common disease pathway, and thus identify individuals with IDD who might ultimately benefit from specific treatments. After briefly demonstrating the need and potential for scope, examples from studies examining brain function and structure in children with autism spectrum disorder (ASD) illustrate how measures of brain neuronal function (from magnetoencephalography, MEG), brain structure (from magnetic resonance imaging, MRI, especially diffusion MRI), and brain chemistry (MR spectroscopy) can help us better understand the heterogeneity in ASD and form the basis of multivariate biological markers (biomarkers) useable to define clinical subpopulations. Similar approaches can be applied to understand brain dysfunction in neurodevelopmental disorders (NDD) in general. In large part, this paper represents our endeavors as part of the CHOP/Penn NICHD-funded intellectual and developmental disabilities research center (IDDRC) over the past decade.


Assuntos
Transtorno do Espectro Autista , Magnetoencefalografia , Transtorno do Espectro Autista/diagnóstico , Biomarcadores , Encéfalo/diagnóstico por imagem , Criança , Potenciais Evocados Auditivos , Humanos
9.
J Neurosci Methods ; 363: 109352, 2021 11 01.
Artigo em Inglês | MEDLINE | ID: mdl-34508784

RESUMO

BACKGROUND: Statistical detection methods are routinely used to automate auditory evoked response (AER) detection and assist clinicians with AER measurements. However, many of these methods are built around statistical assumptions that can be violated for AER data, potentially resulting in reduced or unpredictable test performances. This study explores a frequency domain bootstrap (FDB) and some FDB modifications to preserve test performance in serially correlated non-stationary data. METHOD: The FDB aims to generate many surrogate recordings, all with similar serial correlation as the original recording being analysed. Analysing the surrogates with the detection method then gives a distribution of values that can be used for inference. A potential limitation of the conventional FDB is the assumption of stationary data with a smooth power spectral density (PSD) function, which is addressed through two modifications. COMPARISONS WITH EXISTING METHODS: The FDB was compared to a conventional parametric approach and two modified FDB approaches that aim to account for heteroskedasticity and non-smooth PSD functions. Hotelling's T2(HT2) test applied to auditory brainstem responses was the test case. RESULTS: When using conventional HT2, false-positive rates deviated significantly from the nominal alpha-levels due to serial correlation. The false-positive rates of the modified FDB were consistently closer to the nominal alpha-levels, especially when data was strongly heteroskedastic or the underlying PSD function was not smooth due to e.g. power lines noise. CONCLUSION: The FDB and its modifications provide accurate, recording-dependent approximations of null distributions, and an improved control of false-positive rates relative to parametric inference for auditory brainstem response detection.


Assuntos
Potenciais Evocados Auditivos do Tronco Encefálico , Potenciais Evocados Auditivos , Ruído
10.
Eur J Neurosci ; 54(9): 7274-7288, 2021 11.
Artigo em Inglês | MEDLINE | ID: mdl-34549472

RESUMO

Auditory object analysis requires the fundamental perceptual process of detecting boundaries between auditory objects. However, the dynamics underlying the identification of discontinuities at object boundaries are not well understood. Here, we employed a synthetic stimulus composed of frequency-modulated ramps known as 'acoustic textures', where boundaries were created by changing the underlying spectrotemporal statistics. We collected magnetoencephalographic (MEG) data from human volunteers and observed a slow (<1 Hz) post-boundary drift in the neuromagnetic signal. The response evoking this drift signal was source localised close to Heschl's gyrus (HG) bilaterally, which is in agreement with a previous functional magnetic resonance imaging (fMRI) study that found HG to be involved in the detection of similar auditory object boundaries. Time-frequency analysis demonstrated suppression in alpha and beta bands that occurred after the drift signal.


Assuntos
Córtex Auditivo , Estimulação Acústica , Mapeamento Encefálico , Potenciais Evocados Auditivos , Humanos , Imageamento por Ressonância Magnética , Magnetoencefalografia
11.
Transl Psychiatry ; 11(1): 484, 2021 09 18.
Artigo em Inglês | MEDLINE | ID: mdl-34537812

RESUMO

Relatively little is investigated regarding the neurophysiology of adult attention-deficit/hyperactivity disorder (ADHD). Mismatch negativity (MMN) is an event-related potential component representing pre-attentive auditory processing, which is closely associated with cognitive status. We investigated MMN features as biomarkers to classify drug-naive adult patients with ADHD and healthy controls (HCs). Sensor-level features (amplitude and latency) and source-level features (source activation) of MMN were investigated and compared between the electroencephalograms of 34 patients with ADHD and 45 HCs using a passive auditory oddball paradigm. Correlations between MMN features and ADHD symptoms were analyzed. Finally, we applied machine learning to differentiate the two groups using sensor- and source-level features of MMN. Adult patients with ADHD showed significantly lower MMN amplitudes at the frontocentral electrodes and reduced MMN source activation in the frontal, temporal, and limbic lobes, which were closely associated with MMN generators and ADHD pathophysiology. Source activities were significantly correlated with ADHD symptoms. The best classification performance for adult ADHD patients and HCs showed an 81.01% accuracy, 82.35% sensitivity, and 80.00% specificity based on MMN source activity features. Our results suggest that abnormal MMN reflects the adult ADHD patients' pathophysiological characteristics and might serve clinically as a neuromarker of adult ADHD.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade , Preparações Farmacêuticas , Adulto , Transtorno do Deficit de Atenção com Hiperatividade/diagnóstico , Percepção Auditiva , Eletroencefalografia , Potenciais Evocados Auditivos , Humanos , Aprendizado de Máquina
12.
J Cogn Neurosci ; 33(8): 1549-1562, 2021 07 01.
Artigo em Inglês | MEDLINE | ID: mdl-34496376

RESUMO

Our understanding of the sensory environment is contextualized on the basis of prior experience. Measurement of auditory ERPs provides insight into automatic processes that contextualize the relevance of sound as a function of how sequences change over time. However, task-independent exposure to sound has revealed that strong first impressions exert a lasting impact on how the relevance of sound is contextualized. Dynamic causal modeling was applied to auditory ERPs collected during presentation of alternating pattern sequences. A local regularity (a rare p = .125 vs. common p = .875 sound) alternated to create a longer timescale regularity (sound probabilities alternated regularly creating a predictable block length), and the longer timescale regularity changed halfway through the sequence (the regular block length became shorter or longer). Predictions should be revised for local patterns when blocks alternated and for longer patterning when the block length changed. Dynamic causal modeling revealed an overall higher precision for the error signal to the rare sound in the first block type, consistent with the first impression. The connectivity changes in response to errors within the underlying neural network were also different for the two blocks with significantly more revision of predictions in the arrangement that violated the first impression. Furthermore, the effects of block length change suggested errors within the first block type exerted more influence on the updating of longer timescale predictions. These observations support the hypothesis that automatic sequential learning creates a high-precision context (first impression) that impacts learning rates and updates to those learning rates when predictions arising from that context are violated. The results further evidence automatic pattern learning over multiple timescales simultaneously, even during task-independent passive exposure to sound.


Assuntos
Aprendizado Profundo , Estimulação Acústica , Percepção Auditiva , Eletroencefalografia , Potenciais Evocados Auditivos , Humanos
13.
Eur J Neurosci ; 54(7): 6553-6574, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34486754

RESUMO

N40 is a well-known component of evoked potentials with respect to the auditory and somatosensory modality but not much recognized with regard to the visual modality. To be detected with event-related potentials (ERPs), it requires an optimal signal-to-noise ratio. To investigate the nature of visual N40, we recorded EEG/ERP signals from 20 participants. Each of them was presented with 1800 spatial frequency gratings of 0.75, 1.5, 3 and 6 c/deg. Data were collected from 128 sites while participants were engaged in both passive viewing and attention conditions. N40 (30-55 ms) was modulated by alertness and selective attention; in fact, it was larger to targets than irrelevant and passively viewed spatial frequency gratings. Its strongest intracranial sources were the bilateral thalamic nuclei of pulvinar, according to swLORETA. The active network included precuneus, insula and inferior parietal lobule. An N80 component (60-90 ms) was also identified, which was larger to targets than irrelevant/passive stimuli and more negative to high than low spatial frequencies. In contrast, N40 was not sensitive to spatial frequency per se, nor did it show a polarity inversion as a function of spatial frequency. Attention, alertness and spatial frequency effects were also found for the later components P1, N2 and P300. The attentional effects increased in magnitude over time. The data showed that ERPs can pick up the earliest synchronized activity, deriving in part from thalamic nuclei, before the visual information has actually reached the occipital cortex.


Assuntos
Potenciais Evocados Visuais , Couro Cabeludo , Atenção , Eletroencefalografia , Potenciais Evocados , Potenciais Evocados Auditivos , Humanos , Estimulação Luminosa
14.
Eur J Neurosci ; 54(9): 7193-7213, 2021 11.
Artigo em Inglês | MEDLINE | ID: mdl-34585451

RESUMO

Repetition effects and change detection response have been proposed as neuro-electrophysiological correlates of fundamental learning processes. As such, they could be a good predictor of brain maturation and cognitive development. We recorded high density EEG in 71 healthy infants (32 females) aged between 3 and 9 months, while they listened to vowel sequences (standard /a/a/a/i/ [80%] and deviant /a/a/a/a/ [20%]). Adaptive skills, a surrogate of cognitive development, were measured via the parent form of the Adaptive Behavior Assessment System Second Edition (ABAS-II). Cortical auditory-evoked potentials (CAEPs) analyses, time-frequency analyses and a statistical approach using linear mixed models (LMMs) and linear regression models were performed. Age and adaptive skills were tested as predictors. Age modulation of repetition effects and change detection response was observed in theta (3-5 Hz), alpha (5-10 Hz) and high gamma (80-90 Hz) oscillations and in all CAEPs. Moreover, adaptive skills modulation of repetition effects was evidenced in theta (3-5 Hz), high gamma oscillations (80-90 Hz), N250/P350 peak-to-peak amplitude and P350 latency. Finally, adaptive skills modulation of change detection response was observed in the N250/P350 peak-to-peak amplitude. Our results confirm that repetition effects and change detection response evolve with age. Moreover, our results suggest that repetition effects and change detection response vary according to adaptive skills displayed by infants during the first year of life, demonstrating their predictive value for neurodevelopment.


Assuntos
Percepção Auditiva , Potenciais Evocados Auditivos , Estimulação Acústica , Cognição , Eletroencefalografia , Feminino , Humanos , Lactente , Aprendizagem
15.
Psychiatry Res ; 304: 114162, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34380086

RESUMO

Abnormalities of early and middle latency auditory event-related potentials (ERPs) are widespread in schizophrenia and have been suggested to be associated with cognitive deficits in schizophrenia patients. In this cross-sectional study with schizophrenia patients (n=30) and psychiatrically healthy counterparts (n=31) (matched for age, sex, education), we investigated whether auditory information processing (measured via amplitudes and gating of the auditory ERPs P50, N100 and P200) correlates with neuropsychological performance across cognitive domains. The groups differed significantly in amplitudes and gating of N100 and P200 potentials as well as in neuropsychological performance, but not in P50 amplitude and gating. Neither amplitudes nor gating of auditory ERPs correlated with neuropsychological performance. Neuropsychological intergroup differences could not be explained by abnormalities in auditory information processing. Although pronounced impairments exist on the levels of both auditory information processing and cognitive performance in schizophrenia, these abnormalities are not directly associated with each other.


Assuntos
Esquizofrenia , Estimulação Acústica , Estudos Transversais , Eletroencefalografia , Potenciais Evocados , Potenciais Evocados Auditivos , Humanos , Esquizofrenia/complicações
16.
Biol Psychol ; 164: 108161, 2021 09.
Artigo em Inglês | MEDLINE | ID: mdl-34333068

RESUMO

Mismatch Negativity (MMN) to pattern deviations reveals exquisite pattern detection ability in the brain. MMN amplitude is proposed to be precision-weighted, being inversely proportional to variability within a patterned sound sequence. Two experiments were conducted to determine whether pattern variability, shown to influence MMN to simple pattern deviance, also extends to MMN elicited to abstract pattern deviants. Participants were presented with 3-tone triplet sequences that were defined by regular frequency ascendance with adjacent (A C deviants for adjacent and non-adjacent dependencies, was smaller for the latter, was impervious to variance in tone loudness, but showed prolonged sensitivity to the level of variability at sequence onset.


Assuntos
Encéfalo , Potenciais Evocados Auditivos , Estimulação Acústica , Encéfalo/diagnóstico por imagem , Humanos , Som
17.
Artigo em Inglês | MEDLINE | ID: mdl-34406943

RESUMO

Mismatch negativity (MMN) has been consistently found deficit in schizophrenia, which was considered as a promising biomarker for assessing the impairments in pre-attentive auditory processing. However, the functional connectivity between brain regions based on MMN is not clear. This study provides an in-depth investigation in brain functional connectivity during MMN process among patients with first-episode schizophrenia (FESZ), chronic schizophrenia (CSZ) and healthy control (HC). Electroencephalography (EEG) data of 128 channels is recorded during frequency and duration MMN in 40 FESZ, 40 CSZ patients and 40 matched HC subjects. We reconstruct the cortical endogenous electrical activity from EEG recordings using exact low-resolution electromagnetic tomography and build functional brain networks based on source-level EEG data. Then, graph-theoretic features are extracted from the brain networks with the support vector machine (SVM) to classify FESZ, CSZ and HC groups, since the SVM has good generalization ability and robustness as a universally applicable nonlinear classifier. Furthermore, we introduce the graph neural network (GNN) model to directly learn for the network topology of brain network. Compared to HC, the damaged brain areas of CSZ are more extensive than FESZ, and the damaged area involved the auditory cortex. These results demonstrate the heterogeneity of the impacts of schizophrenia for different disease courses and the association between MMN and the auditory cortex. More importantly, the GNN classification results are significantly better than those of SVM, and hence the EEG-based GNN model of brain networks provides an effective method for discriminating among FESZ, CSZ and HC groups.


Assuntos
Esquizofrenia , Estimulação Acústica , Atenção , Encéfalo , Eletroencefalografia , Potenciais Evocados Auditivos , Humanos , Redes Neurais de Computação
18.
Am J Psychiatry ; 178(10): 952-964, 2021 10 01.
Artigo em Inglês | MEDLINE | ID: mdl-34407624

RESUMO

OBJECTIVE: Neural activations during auditory oddball tasks may be endophenotypes for psychosis and bipolar disorder. The authors investigated oddball neural deviations that discriminate multiple diagnostic groups across the schizophrenia-bipolar spectrum (schizophrenia, schizoaffective disorder, psychotic bipolar disorder, and nonpsychotic bipolar disorder) and clarified their relationship to clinical and cognitive features. METHODS: Auditory oddball responses to standard and target tones from 64 sensor EEG recordings were compared across patients with psychosis (total N=597; schizophrenia, N=225; schizoaffective disorder, N=201; bipolar disorder with psychosis, N=171), patients with bipolar disorder without psychosis (N=66), and healthy comparison subjects (N=415) from the second iteration of the Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP2) study. EEG activity was analyzed in voltage and in the time-frequency domain (low, beta, and gamma bands). Event-related potentials (ERPs) were compared with those from an independent sample collected during the first iteration of B-SNIP (B-SNIP1; healthy subjects, N=211; psychosis group, N=526) to establish the repeatability of complex oddball ERPs across multiple psychosis syndromes (r values >0.94 between B-SNIP1 and B-SNIP2). RESULTS: Twenty-six EEG features differentiated the groups; they were used in discriminant and correlational analyses. EEG variables from the N100, P300, and low-frequency ranges separated the groups along a diagnostic continuum from healthy to bipolar disorder with psychosis/bipolar disorder without psychosis to schizoaffective disorder/schizophrenia and were strongly related to general cognitive function (r=0.91). P50 responses to standard trials and early beta/gamma frequency responses separated the bipolar disorder without psychosis group from the bipolar disorder with psychosis group. P200, N200, and late beta/gamma frequency responses separated the two bipolar disorder groups from the other groups. CONCLUSIONS: Neural deviations during auditory processing are related to psychosis history and bipolar disorder. There is a powerful transdiagnostic relationship between severity of these neural deviations and general cognitive performance. These results have implications for understanding the neurobiology of clinical syndromes across the schizophrenia-bipolar spectrum that may have an impact on future biomarker research.


Assuntos
Vias Auditivas/fisiopatologia , Transtorno Bipolar , Eletroencefalografia/métodos , Vias Neurais/fisiopatologia , Transtornos Psicóticos , Estimulação Acústica/métodos , Adulto , Transtorno Bipolar/diagnóstico , Transtorno Bipolar/fisiopatologia , Transtorno Bipolar/psicologia , Cognição , Correlação de Dados , Diagnóstico Diferencial , Potenciais Evocados Auditivos , Feminino , Humanos , Masculino , Técnicas Psicológicas , Transtornos Psicóticos/diagnóstico , Transtornos Psicóticos/fisiopatologia , Transtornos Psicóticos/psicologia , Índice de Gravidade de Doença
19.
Clin Neurophysiol ; 132(10): 2654-2665, 2021 10.
Artigo em Inglês | MEDLINE | ID: mdl-34456164

RESUMO

OBJECTIVE: Deficits of mismatch negativity (MMN), a general index of echoic memory function, have been documented in patients with schizophrenia. However, it remains controversial whether patients with major depressive disorder (MDD) demonstrate MMN defects compared with healthy controls (HC). METHODS: After screening 41 potential studies identified in PubMed and Medline, 13 studies consisting of 343 HC and 339 patients with MDD were included in the present meta-analysis. The effect sizes (Hedges's g) with a random-effect and inverse-variance weighted model were estimated for the MMN amplitudes and latencies. The effects of different deviant types (i.e., frequency and duration) and of different illness stages (i.e., acute and chronic) on MMN were also examined. RESULTS: We found that 1) MMN amplitudes (g = 1.273, p < 0.001) and latencies (g = 0.303, p = 0.027) to duration, but not frequency deviants, were significantly impaired in patients with MDD compared to HC; 2), acute patients exhibited lower MMN amplitudes (g = 1.735, p < 0.001) and prolonged MMN latencies (g = 0.461, p = 0.007) for the duration deviants compared to HC. Only the attenuated duration MMN amplitudes were detected in patients with chronic MDD (g = 0.822, p = 0.027); and 3) depressive symptoms did not significantly correlate with MMN responses. CONCLUSIONS: Patients with MDD demonstrated abnormal MMN responses to duration deviants compared to HC. SIGNIFICANCE: Duration MMN may constitute an electrophysiological indicator to differentiate HC from patients with MDD, particularly those in the acute stage.


Assuntos
Estimulação Acústica/métodos , Percepção Auditiva/fisiologia , Transtorno Depressivo Maior/diagnóstico , Transtorno Depressivo Maior/fisiopatologia , Eletroencefalografia/métodos , Potenciais Evocados Auditivos/fisiologia , Transtorno Depressivo Maior/psicologia , Humanos
20.
J Speech Lang Hear Res ; 64(10): 4014-4029, 2021 10 04.
Artigo em Inglês | MEDLINE | ID: mdl-34464537

RESUMO

Purpose Background noise has been categorized as energetic masking due to spectrotemporal overlap of the target and masker on the auditory periphery or informational masking due to cognitive-level interference from relevant content such as speech. The effects of masking on cortical and sensory auditory processing can be objectively studied with the cortical auditory evoked potential (CAEP). However, whether effects on neural response morphology are due to energetic spectrotemporal differences or informational content is not fully understood. The current multi-experiment series was designed to assess the effects of speech versus nonspeech maskers on the neural encoding of speech information in the central auditory system, specifically in terms of the effects of speech babble noise maskers varying by talker number. Method CAEPs were recorded from normal-hearing young adults in response to speech syllables in the presence of energetic maskers (white or speech-shaped noise) and varying amounts of informational maskers (speech babble maskers). The primary manipulation of informational masking was the number of talkers in speech babble, and results on CAEPs were compared to those of nonspeech maskers with different temporal and spectral characteristics. Results Even when nonspeech noise maskers were spectrally shaped and temporally modulated to speech babble maskers, notable changes in the typical morphology of the CAEP in response to speech stimuli were identified in the presence of primarily energetic maskers and speech babble maskers with varying numbers of talkers. Conclusions While differences in CAEP outcomes did not reach significance by number of talkers, neural components were significantly affected by speech babble maskers compared to nonspeech maskers. These results suggest an informational masking influence on neural encoding of speech information at the sensory cortical level of auditory processing, even without active participation on the part of the listener.


Assuntos
Percepção da Fala , Fala , Potenciais Evocados Auditivos , Humanos , Ruído , Mascaramento Perceptivo , Adulto Jovem
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