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1.
Minerva Pediatr ; 71(6): 500-504, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31840969

RESUMO

BACKGROUND: Neonatal conjunctivitis is frequent and could benefit from daily cleansing with saline. Anyway super infections can occur and therefore antibiotics are frequently needed. Recently alternative therapies (e.g. Echinacea angustifolia) are used for neonatal conjunctivitis to try to reduce antibiotics therapy. The aim of the study was to verify if the use of gauze containing Echinacea angustifolia compared to standard sodium-chloride at the onset of conjunctivitis symptoms is effective in reducing the clinical symptoms and the risk for superinfections. METHODS: The study was randomized and controlled. Neonates admitted in a tertiary level Neonatal Intensive Care Unit (NICU), with clinical signs of conjunctivitis during hospital stay, were randomized in two groups: group A (3 times daily ocular cleansing for 48 h with sterile gauze; group B (3 times daily ocular cleansing for 48 h with Iridium® baby gauze (Neoox) containing Echinacea angustifolia and pineapple sativus). An eye swab for cultural analysis was taken at time of presentation (T0) prior to treatment and at the end of ocular cleansing (T1). RESULTS: Sixty-three neonates were enrolled (GrA=30 and GrB=33). At T0, eye specimen positivity was found in 16/30 (48%) in group A and in 18/33 (55%) in group B (P=0.9). No statistical differences among groups at T0 regarding culture positivity. After 48 h, babies in Gr A have significantly fewer positive swabs compared to group B (group A: 18/29, group B: 10/32; P=0.009). Neonates in group B who had negative swab at T0 had a significantly reduced risk to have positive culture at T1 (OR 0.28, CI: 0.10-0,80, P=0.01), also considering confounding factors (birth weight, gestational age, mode of delivery) (adjusted OR 0.15, CI: 0.03-0.52, P<0.01). No differences in regard to antibiotic needs (P=0.95) during the course of conjunctivitis between groups. CONCLUSIONS: Our data suggest that these gauzes containing Echinacea angustifolia might help in avoiding super-infections, contaminations and in reducing ocular bacterial load.


Assuntos
Conjuntivite/terapia , Echinacea/química , Doenças do Recém-Nascido/terapia , Cloreto de Sódio/administração & dosagem , Ananas/química , Bandagens , Humanos , Recém-Nascido , Unidades de Terapia Intensiva Neonatal , Preparações de Plantas/administração & dosagem , Resultado do Tratamento
2.
World J Gastroenterol ; 25(40): 6129-6144, 2019 Oct 28.
Artigo em Inglês | MEDLINE | ID: mdl-31686768

RESUMO

BACKGROUND: Constipation is a common functional gastrointestinal disorder and its etiology is multifactorial. Growing evidence suggests that intestinal dysbiosis is associated with the development of constipation. Prebiotics are subjected to bacterial fermentation in the gut to produce short-chain fatty acids (SCFAs), which can help relieve constipation symptoms. The prebiotic UG1601 consists of inulin, lactitol, and aloe vera gel, which are known laxatives, but randomized, controlled clinical trials that examine the effects of this supplement on gut microbiota composition are lacking. AIM: To assess the efficacy of the prebiotic UG1601 in suppressing constipation-related adverse events in subjects with mild constipation. METHODS: Adults with a stool frequency of less than thrice a week were randomized to receive either prebiotics or a placebo supplement for 4 wk. All participants provided their fecal and blood samples at baseline and at the end of intervention. Gastrointestinal symptoms and stool frequency were evaluated. The concentrations of serum endotoxemia markers and fecal SCFAs were determined. The relative abundance of SCFA-producing bacteria and the gut microbial community in the responders and non-responders in the prebiotics supplementation group were evaluated. RESULTS: There were no significant differences in gastrointestinal symptoms between groups, although the prebiotic group showed greater symptom improvement. However, after prebiotic usage, serum cluster of differentiation (CD) 14 and lipopolysaccharide (LPS) concentrations were significantly decreased (CD14, P = 0.012; LPS, P < 0.001). The change in LPS concentration was significantly larger in the prebiotic group than in the placebo group (P < 0.001). Fecal SCFAs concentrations did not differ between groups, while the relative abundance of Roseburia hominis, a major butyrate producer, was significantly increased in the prebiotic group (P = 0.045). The abundances of the phylum Firmicutes and the family Lachnospiraceae (phylum Firmicutes, class Clostridia) (P = 0.009) were decreased in the responders within the prebiotic group. In addition, the proportions of the phylum Firmicutes, the class Clostridia, and the order Clostridiales were inversely correlated with several fecal SCFAs (P < 0.05). CONCLUSION: Alterations in gut microbiota composition, including a decrease in the phylum Firmicutes and an increase in butyrate-producing bacteria, following prebiotic UG1601 supplementation might help alleviate symptom scores and endotoxemia.


Assuntos
Constipação Intestinal/dietoterapia , Disbiose/dietoterapia , Endotoxemia/dietoterapia , Microbioma Gastrointestinal/efeitos dos fármacos , Prebióticos/administração & dosagem , Adulto , Clostridiales/efeitos dos fármacos , Clostridiales/isolamento & purificação , Constipação Intestinal/complicações , Constipação Intestinal/diagnóstico , Método Duplo-Cego , Disbiose/diagnóstico , Disbiose/microbiologia , Endotoxemia/diagnóstico , Endotoxemia/microbiologia , Ácidos Graxos Voláteis/análise , Fezes/química , Fezes/microbiologia , Feminino , Humanos , Inulina/administração & dosagem , Masculino , Pessoa de Meia-Idade , Placebos/administração & dosagem , Preparações de Plantas/administração & dosagem , Índice de Gravidade de Doença , Álcoois Açúcares/administração & dosagem , Resultado do Tratamento , Adulto Jovem
3.
Food Funct ; 10(9): 6088-6097, 2019 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-31490512

RESUMO

Nonsteroidal anti-inflammatory drugs (NSAIDs) are well-known for exerting numerous adverse effects on the gastrointestinal tract such as bleeding, ulceration, and perforation, thereby limiting their use. Most previous studies have focused on NSAID-induced gastropathy. However, improved diagnostic techniques have recently highlighted NSAID-induced small intestinal ulcers, which have so far been underestimated. While proton pump inhibitors are prescribed to control NSAID-induced gastropathy, few preventive strategies are existent for NSAID-induced small intestinal injury, thus requiring new methods to treat these enteropathies. Numerous studies have reported the beneficial biological effects of Aloe vera, such as wound healing, anti-cancer, immune modulation, anti-oxidant, anti-microbial, and gastroprotective effects. A previous report on the effect of Aloe vera against NSAID-induced ulcers studied only gastric ulcers and elucidated the results as an anti-inflammatory effect of Aloe vera. However, ulcer prevention cannot be justified entirely to be due to the anti-inflammatory effects of Aloe vera, since NSAIDs themselves also exert an anti-inflammatory reaction. We therefore investigated the anti-ulcer effects of Aloe vera on the small intestine, especially focusing on mucin expression. Our results indicate that processed Aloe vera gel (PAG) treatment attenuates not only the severity of intestinal ulcers but also bacterial translocation, by enhancing the mucus layer in the indomethacin-induced small intestinal damage mouse model. We further confirmed that PAG positively regulates the mucin expression in the LS174T human cell line, mainly via the ERK-dependent pathway. We propose that PAG application is a potential strategy for the alleviation of NSAID-induced small intestinal ulcers.


Assuntos
Anti-Inflamatórios não Esteroides/efeitos adversos , Enteropatias/tratamento farmacológico , Intestino Delgado/lesões , Mucinas/genética , Preparações de Plantas/administração & dosagem , Animais , Linhagem Celular , Expressão Gênica/efeitos dos fármacos , Humanos , Enteropatias/induzido quimicamente , Enteropatias/genética , Enteropatias/metabolismo , Intestino Delgado/efeitos dos fármacos , Intestino Delgado/metabolismo , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Mucinas/metabolismo , Preparações de Plantas/química
4.
Complement Ther Clin Pract ; 37: 68-72, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31491603

RESUMO

BACKGROUND AND PURPOSE: Somatic symptom disorder (SSD) refers to a significant impairment in daily activities due to a dysfunctional preoccupation with one or more physical symptoms. This study reports the effectiveness of herbal medicine (HM) on SSD patient. MATERIALS AND METHODS: A 58-year-old woman had somatic atypical gastrointestinal symptoms for 5 years; i.e., an uncomfortable feeling going from the stomach to the ear as well as related severe anxiety. A Korean medicine (KM) doctor presumed she had SSD and phlegm-dampness syndrome, consequently, Xiao Ban Xia Jia Fu Ling Tang was administered. Her anxiety symptoms were rated using the numerical rating scale and the Beck anxiety inventory. RESULTS: The somatic symptoms originating in the stomach and chest, as well as the severe anxiety, improved markedly after 2 months of KM treatment. CONCLUSION: HMs used for treating phlegm-dampness syndrome may be effective in treating conditions involving somatic symptoms and related anxiety.


Assuntos
Ansiedade/terapia , Preparações de Plantas/administração & dosagem , Plantas Medicinais/química , Transtornos Somatoformes/terapia , Feminino , Gastroenteropatias/psicologia , Gastroenteropatias/terapia , Humanos , Sintomas Inexplicáveis , Pessoa de Meia-Idade
5.
Anim Sci J ; 90(9): 1248-1260, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31321863

RESUMO

This study was conducted to evaluate the effects of supplementation of Wakame seaweed stalks on the immunity and intestinal microflora of pigs. Three separate experiments were performed: Relatively young (start at 20-30 kg; Experiments 1 and 2) and fattening period (70 kg; Experiment 3). All pigs (including the control group) were fed the same commercial feed, free from antibiotic additives, but in the feed for the treatment groups, 1% seaweed powder was added. There were no group differences observed in daily weight gain and feed intake in Experiments 1 and 2 between groups; however, daily weight gain was significantly higher in the treatment group compared to the control group in Experiment 3. The percentage of peripheral blood natural killer cells of the treatment group was significantly higher than that of the control group in all experiments. Although addition of seaweed changed the gene expression of cytokine and toll-like receptors of the small intestinal Peyer's patches slightly, seaweed seems to alter intestinal microflora preferentially, for instance, there was an increase in Lactobacillus and a decrease of Escherichia coli observed. These results suggest that Wakame seaweed can be used as supplement for pig feed to improve the gut health and immunity of pigs.


Assuntos
Ração Animal , Suplementos Nutricionais , Microbioma Gastrointestinal/efeitos dos fármacos , Imunidade/efeitos dos fármacos , Alga Marinha , Undaria , Ganho de Peso/efeitos dos fármacos , Animais , Escherichia coli/efeitos dos fármacos , Lactobacillus/efeitos dos fármacos , Preparações de Plantas/administração & dosagem , Suínos
6.
Planta Med ; 85(13): 1044-1053, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31261419

RESUMO

This prospective, noninterventional, multicenter 12-wk study in women with overactive bladder investigated the effectiveness of Granu Fink femina, a herbal combination of seed oil from Uromedic pumpkin (cultivar of Cucurbita pepo), Rhus aromatica (fragrant sumach) bark extract, and Humulus lupulus (hop) cone extract in a clinical setting. Patients documented overactive bladder symptoms and quality of life using questionnaires as well as diaries recording day- and nighttime micturition frequencies, urine leakages during physical activity or at sneezing or coughing, and use of incontinence pads. The full analysis set included 117 women (age: 21 - 78 y). Urination frequency decreased significantly with improvement during daytime in 49, 71, and 77 (out of 99) patients and at night in 45, 63, and 70 (out of 100) patients after 1, 6, and 12 wk, respectively. The mean frequency of leakages and used pads decreased significantly from 0.9 leakages and 2.0 pads at baseline to 0.4 leakages and 1.4 pads after 12 wk. In all measured aspects of overactive bladder-related quality of life, (coping, concern, sleep, social), statistically significant improvement was reached after 1 wk, with further improvement at 6 and 12 wk. Ninety-nine percent of the physicians and 95.4% of the patients rated tolerability as "very good" or "good". Treatment with Granu Fink femina progressively improved overactive bladder symptoms and related quality of life with significant improvements already after 1 wk. Based on these effects and the observed excellent tolerability profile, Granu Fink femina may be considered a valuable therapeutic option for overactive bladder.


Assuntos
Cucurbita , Humulus , Fitoterapia/métodos , Preparações de Plantas/uso terapêutico , Rhus , Bexiga Urinária Hiperativa/tratamento farmacológico , Adulto , Idoso , Feminino , Medicina Herbária/métodos , Humanos , Pessoa de Meia-Idade , Preparações de Plantas/administração & dosagem , Adulto Jovem
7.
Medicine (Baltimore) ; 98(30): e16466, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31348248

RESUMO

INTRODUCTION: In Korea, low back pain (LBP) which is occupation-related symptom is one of the major health issues owing to rapid industrialization. Even traditional Korean medicine has the long history in pain treatment, there still has been lack of supporting evidence on herbal prescription itself. Sogyeonghwalhyeol-tang, a Korean herbal medicine prescription, has been suggested as a medication for treating chronic LBP as well as work-related pains. OBJECTIVE: This study aims to evaluate the clinical efficacy and safety of herbal medicine, Sogyeonghwalhyeol-tang on work-related chronic LBP patients. METHOD: This trial is designed as a multicenter, randomized, controlled, clinical trial. Seventy-two participants who have chief complaint of LBP in Korean medicine rehabilitation center will be randomly assigned to ether Sogyeonghwalhyeol-tang group or placebo group with a ratio of 1:1. They will receive assigned drugs in 4 weeks and follow-up for 2 weeks. DISCUSSION: The result of this study will provide the valuable information for efficacy and safety of Sogyeonghwalhyeol-tang for patients with work-related chronic LBP.


Assuntos
Dor Lombar/tratamento farmacológico , Medicina Tradicional Coreana/métodos , Doenças Profissionais/tratamento farmacológico , Preparações de Plantas/uso terapêutico , Método Duplo-Cego , Humanos , Medição da Dor , Preparações de Plantas/administração & dosagem , Preparações de Plantas/efeitos adversos , Qualidade de Vida , República da Coreia
8.
Cien Saude Colet ; 24(5): 1733-1742, 2019 May 30.
Artigo em Português | MEDLINE | ID: mdl-31166508

RESUMO

There has been significant growth in the number of municipal phytotherapy programs in the Unified Health System since the launch of the National Policy of Medicinal Plants in 2006. The aim of the research was to analyze how these programs are distributed throughout Brazil, how they express regional diversity and how land use can influence these programs and promote broad technical synergy (local knowledge and universal knowledge) and policy (strategy and actors) in the production, circulation, distribution and dispe sation of medicinal plants in the public health system. The analysis involved a theoretical framework of critical geography and public health, conceptual and thematic literature review, document analysis, survey of primary and secondary data along with extensive fieldwork. The results show that the growth of programs was accompanied by the choice of industrialized herbal medicines, spatially concentrated in the South and Southeast. Two phases were identified in this process: 1980-2008 characterized by horizontal actions linked to regional diversities; 2008 to the present characterized by verticalized actions on a national scale. The National Policy made it possible to increase the number of programs but did little to promote greater regional diversity.


Assuntos
Medicina Tradicional/métodos , Fitoterapia/métodos , Preparações de Plantas/administração & dosagem , Plantas Medicinais/química , Brasil , Política de Saúde , Humanos , Programas Nacionais de Saúde/organização & administração , Fitoterapia/tendências
9.
Dermatol Ther ; 32(4): e12995, 2019 07.
Artigo em Inglês | MEDLINE | ID: mdl-31197923

RESUMO

Miliaria crystallina is a skin disorder that often erupts in the process of febrile diseases or under hot and humid climatic conditions. Toxic epidermal necrolysis (TEN) is a rare, acute, and life-threatening mucocutaneous disease with a mortality rate of 25-35%. There has been no inevitable connection between the two diseases among previously reported cases, but we observed a case of secondary miliaria crystallina a woman with herbal remedies-induced TEN during the therapeutic process.


Assuntos
Miliária/etiologia , Preparações de Plantas/efeitos adversos , Síndrome de Stevens-Johnson/etiologia , Adulto , Feminino , Humanos , Miliária/patologia , Fitoterapia/efeitos adversos , Preparações de Plantas/administração & dosagem , Síndrome de Stevens-Johnson/patologia
10.
Intern Med ; 58(17): 2459-2465, 2019 Sep 01.
Artigo em Inglês | MEDLINE | ID: mdl-31178508

RESUMO

Objective Kikyo-to (KKT) is a fixed combination of glycyrrhiza root and platycodon root extracts. It is an herbal medicine traditionally used in Japan for relieving sore throat associated with acute upper respiratory tract infection (URTI). No controlled studies have yet demonstrated its effect, however. We investigated the efficacy of KKT on sore throat associated with acute URTI. Methods Patients with sore throat who were diagnosed with URTI at the General Medicine Department Office, Akashi Medical Center Hospital, between December 2017 and May 2018 were enrolled. Participants were randomly assigned to two groups at a 1:1 ratio, with stratification by age and sore throat score on a Visual Analogue Scale (VAS), to receive 2.5 g of either KKT or a placebo. Participants and investigators were blinded to group allocation. The primary outcome was the change in sore throat score on VAS 10 minutes after KKT administration. Secondary outcomes were the impact of the sore throat on daily life (none, mild, moderate, and severe) at 10 minutes after administration. Results Thirty-five participants were assigned to each group (n=70, total). The difference in the mean change of sore throat score according to VAS within 10 minutes between the two groups was not statistically significant (KKT 14.40 vs. placebo 17.00; p=0.39). The proportion of patients with a moderate or greater impact of their sore throat on their daily life was also not significantly different between the groups (KKT 22.9% vs. placebo 40.0%; p=0.20). Patients reported no side effects. Conclusion KKT did not significantly relieve sore throat associated with acute URTI compared with placebo.


Assuntos
Medicina Tradicional do Leste Asiático/métodos , Faringite/tratamento farmacológico , Faringite/etiologia , Preparações de Plantas/uso terapêutico , Infecções Respiratórias/complicações , Adulto , Método Duplo-Cego , Feminino , Humanos , Japão , Masculino , Pessoa de Meia-Idade , Fitoterapia , Preparações de Plantas/administração & dosagem , Preparações de Plantas/efeitos adversos , Fatores de Tempo
11.
Planta Med ; 85(11-12): 934-940, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31216580

RESUMO

Malaria treatment and control have become increasingly difficult because of the spread of drug-resistant strains of Plasmodium falciparum and Plasmodium vivax. Thus, there is a continuous need to develop new combination therapies such as artemisinin-based combination therapies (ACTs) to contrast the emergence of resistant Plasmodium strains. Despite ACT has been recommended by the World Health Organization since 2001, its overall deployment in poor endemic areas is very slow, principally due to its high cost. In the malaria endemic areas, plant remedies are still widely used mostly without assurance of their efficacy and/or safety. A variety of widespread herbal drugs or natural products were already reported for their possible plasmodicidal activities, but the studies concerning their activity in combination with artemisinins are very scarce. The antimalarial activity of papaya is mostly anecdotal, and the present study is aimed at investigating the antiplasmodial activity of a decoction obtained by traditional recipe from the mature leaves of Carica papaya. The decoction was analyzed by HPLC-DAD-MS (high performance liquid chromatography coupled with diodoarray detector and mass spectrometry) showing the presence of caffeoyl derivatives and di- and triglycosides of flavonols. The extract was found to be active against P. falciparum 3D7 strains with a synergism in the presence of artemisinin. In vivo activity against the murine malaria model of Plasmodium berghei was disclosed both for the dried extract alone (250, 500, and 750 mg/kg/d) and for its combination with artesunate (250 mg/kg/d papaya plus 10 mg/kg/d artesunate). This combination displayed the greatest antimalarial activity in terms of reduction of parasitemia and prevention of recrudescence in animals recovered from the infection.


Assuntos
Antimaláricos/uso terapêutico , Artesunato/uso terapêutico , Carica/química , Malária/tratamento farmacológico , Fitoterapia/métodos , Folhas de Planta/química , Preparações de Plantas/uso terapêutico , Plasmodium berghei/efeitos dos fármacos , Animais , Antimaláricos/administração & dosagem , Artesunato/administração & dosagem , Cromatografia Líquida de Alta Pressão , Quimioterapia Combinada , Feminino , Camundongos , Camundongos Endogâmicos BALB C , Preparações de Plantas/administração & dosagem , Recidiva
12.
Nutrients ; 11(6)2019 Jun 25.
Artigo em Inglês | MEDLINE | ID: mdl-31242638

RESUMO

Dietary intake of anthocyanins (ACNs) is associated with a reduced risk of cardiovascular and coronary heart disease. While the anti-inflammatory, antioxidant, and lipid-lowering effects of ACN consumption have been consistently reported, their effect(s) on blood pressure regulation is less consistent and results from human studies are mixed. The objective of this review is attempting to identify potential patterns which may explain the variability in results related to blood pressure. To do so, we review 66 human intervention trials testing the effects on blood pressure of purified ACN or ACN-rich extracts, or whole berries, berry juices, powders, purees and whole phenolic extracts, from berries that are rich in ACN and have ACNs as predominant bioactives. Several factors appear to be involved on the mixed results reported. In particular, the baseline characteristics of the population in terms of blood pressure and total flavonoid intake, the dose and duration of the intervention, the differential effects of individual ACN and their synergistic effects with other phytochemicals, the ACN content and bioavailability from the food matrix, and individual differences in ACN absorption and metabolism related to genotype and microbiota enterotypes.


Assuntos
Antocianinas/administração & dosagem , Anti-Hipertensivos/administração & dosagem , Pressão Sanguínea/efeitos dos fármacos , Hipertensão/tratamento farmacológico , Preparações de Plantas/administração & dosagem , Adolescente , Adulto , Feminino , Humanos , Hipertensão/diagnóstico , Hipertensão/fisiopatologia , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento , Adulto Jovem
13.
BMC Womens Health ; 19(1): 58, 2019 04 30.
Artigo em Inglês | MEDLINE | ID: mdl-31039769

RESUMO

BACKGROUND: Studies have demonstrated that women with low desire and low excitement have negative feelings regarding their physical and emotional satisfaction, as well as their happiness. In this study, we evaluate the efficacy of Libicare® - a multi-ingredient food supplement - to improve sexual function in postmenopausal women. METHODS: This was an exploratory, prospective, non-controlled, observational study. Postmenopausal women aged 45-65 with a risk of sexual dysfunction (Female Sexual Function Index (FSFI) < 25.83) were included during routine clinical visits and treated with 2 tablets of Libicare® daily for 2 months. Libicare® is an oral food supplement containing Trigonella foenum graecum, Turnera diffusa, Tribulus terrestris, and Ginkgo biloba dry extracts. Primary endpoint: change vs. baseline in FSFI score. Secondary endpoints: 1) changes in testosterone and serum steroid levels of free testosterone and sex hormone-binding globulin (SHBG) levels and 2) tolerability. RESULTS: A total of 29 patients (mean age: 54.69 years) were included. FSFI mean (SD) score showed a significant increase: 20.15 (4.48) vs 25.03 (6.94), baseline vs final; p = 0.0011, paired t-test. Most patients (86.2%) increased their FSFI score. All FSFI domains, except dyspareunia, showed significant increases. The highest increase was observed in the desire domain (p = 0.0004). Testosterone and SHBG levels were assessed in 21 patients. A significant increase in testosterone level was observed: 0.41 (0.26) vs. 0.50 (0.34) pg/mL, baseline vs. final; p = 0.038, Wilcoxon test. 52.4% of patients increased their testosterone levels. Finally, a significant decrease was observed in SHBG level: 85 (32.9) vs. 73 (26.8) nmol/L, baseline vs. final; p = 0.0001; paired t-test. 95.2% of patients decreased their SHBG levels. CONCLUSION: In this pilot study, a significant improvement in sexual function and related hormone levels was observed with Libicare®. Further studies must be conducted to confirm these exciting results. TRIAL REGISTRATION: Current Controlled Trial ISRCTN12928573 . Date of registration: 28/March/2019. Retrospectively registered.


Assuntos
Suplementos Nutricionais , Preparações de Plantas/administração & dosagem , Disfunções Sexuais Fisiológicas/tratamento farmacológico , Disfunções Sexuais Psicogênicas/tratamento farmacológico , Feminino , Humanos , Libido/efeitos dos fármacos , Pessoa de Meia-Idade , Satisfação Pessoal , Projetos Piloto , Extratos Vegetais/administração & dosagem , Estudos Prospectivos , Resultado do Tratamento
15.
Dermatol Ther ; 32(4): e12974, 2019 07.
Artigo em Inglês | MEDLINE | ID: mdl-31145512

RESUMO

Typically, most patients in Nigeria would have tried both oral and topical remedies before visiting a dermatology clinic. There are no documentations of what these remedies are. The aim of this study is to determine what remedies patients use and the influence of age, gender, level of education, and marital status on the choice of herbal remedies. This was a retrospective cross-sectional chart review over a 3-year period. Records of all new patients attended to at the dermatology clinic between October 2015 and October 2018 were retrieved and relevant information extracted. Data were analyzed using SPSS version 23.0. A total of 835 new patients were seen during the study period, 56.9% females and 43.1% males. Prior to attending the dermatology clinic, 52.8% had used a remedy which was herbal in 9.1% and Western in 90.9%. Out of those that had used herbal medications, 65% was oral, 27.5% was topical and 7.5% was topical and oral. Out of those that had used Western medications, 63.1% was topical 23.9% was oral and 13% was oral and topical. Herbal and western medications were used in 11 persons. Most Nigerian patients use a Western remedy before dermatology clinic attendance. In the few patients who use herbal remedies, this is independent of age, gender, level of education, diagnosis, and marital status.


Assuntos
Fármacos Dermatológicos/administração & dosagem , Medicina Tradicional Africana/estatística & dados numéricos , Preparações de Plantas/administração & dosagem , Dermatopatias/tratamento farmacológico , Administração Cutânea , Administração Oral , Adulto , Idoso , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Nigéria , Fitoterapia/estatística & dados numéricos , Estudos Retrospectivos , Adulto Jovem
16.
Biomolecules ; 9(5)2019 04 26.
Artigo em Inglês | MEDLINE | ID: mdl-31035513

RESUMO

Chyawanprash (CP) is an Ayurvedic health supplement which is made up of a super-concentrated blend of nutrient-rich herbs and minerals. It is meant to restore drained reserves of life force (ojas) and to preserve strength, stamina, and vitality, while stalling the course of aging. Chyawanprash is formulated by processing around 50 medicinal herbs and their extracts, including the prime ingredient, Amla (Indian gooseberry), which is the world's richest source of vitamin C. Chyawanprash preparation involves preparing a decoction of herbs, followed by dried extract preparation, subsequent mixture with honey, and addition of aromatic herb powders (namely clove, cardamom, and cinnamon) as standard. The finished product has a fruit jam-like consistency, and a sweet, sour, and spicy flavor. Scientific exploration of CP is warranted to understand its therapeutic efficacy. Scattered information exploring the therapeutic potential of CP is available, and there is a need to assemble it. Thus, an effort was made to compile the scattered information from ancient Ayurvedic texts and treatises, along with ethnobotanical, ethnopharmacological, and scientifically validated literature, that highlight the role of CP in therapeutics. Citations relevant to the topic were screened.


Assuntos
Suplementos Nutricionais , Preparações de Plantas/farmacologia , Alimento Funcional , Humanos , Marketing , Compostos Fitoquímicos/análise , Preparações de Plantas/administração & dosagem , Preparações de Plantas/efeitos adversos
17.
Obstet Gynecol ; 133(5): 920-932, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-30969204

RESUMO

OBJECTIVE: To report the incidence and nature of herbal medicinal products' adverse events and herb-drug interactions used by some pregnant and postnatal women. DATA SOURCES: The Allied and Complementary Medicine Database, the Cumulative Index to Nursing and Allied Health Literature, EMBASE, the Cochrane Library, MEDLINE, Scopus, Web of Science, and ClinicalTrials.gov were searched from inception until August 2018. METHODS OF STUDY SELECTION: Any studies reporting adverse events, herb-drug interactions or absence thereof associated with herbal medicinal products used during pregnancy or the postnatal period were included. Conference abstracts, pilot studies, and nonhuman studies were excluded. All included studies were critically appraised by two independent reviewers. TABULATION, INTEGRATION AND RESULTS: Database searches retrieved 3,487 citations. After duplicate removal and review of titles, abstracts, and full-text, 115 articles were critically appraised. After excluding irrelevant and low-quality articles, 74 articles were included for data extraction and synthesis. Adverse drug reactions, congenital malformations, fetal growth retardation or herb-drug interactions were the primary study objective reported by 19 of the 74 included studies, 16 cohort studies, one cross-sectional survey, and two randomized controlled trials. A total of 47 herbal medicinal products and 1,067,071 women were included in this review. Use of almond oil was associated with preterm birth (odds ratio 2.09, 95% CI 1.07-4.08), oral raspberry leaf was associated with cesarean delivery (adjusted odds ratio [AOR] 3.47, 95% CI 1.45-8.28); heavy licorice use was associated with early preterm birth by 3.07-fold (95% CI 1.17-8.05). African herbal medicine mwanaphepo was associated with maternal morbidity (AOR 1.28; 95% CI 1.09-1.50), and neonatal death or morbidity. Fourteen studies reported absence of adverse events. Four studies reported herb-drug interactions, but none studied adverse events arising from them. CONCLUSION: The use of herbal medicinal products during pregnancy and the postnatal period should be discouraged until robust evidence of safety is available. SYSTEMATIC REVIEW REGISTRATION: PROSPERO, CRD42017081058.


Assuntos
Fitoterapia , Preparações de Plantas/provisão & distribução , Cuidado Pré-Natal , Interações Medicamentosas , Feminino , Humanos , Preparações de Plantas/administração & dosagem , Gravidez
18.
Med Oncol ; 36(5): 45, 2019 Apr 16.
Artigo em Inglês | MEDLINE | ID: mdl-30993543

RESUMO

Cancer is becoming more prevalent in elderly patient. Due to polypharmacy, older adults with cancer are predisposed to drug-drug interactions. There is also an increasing interest in the use of complementary and alternative medicine (CAM). Thirty to seventy percent of patients with cancer have used CAM. Through pharmaceutical counseling sessions, we can provide advices on herb-drug interactions (HDI). All the patients seen in pharmaceutical counseling sessions were prospectively included. Information was collected during these sessions: prescribed medication (oral anticancer agents (OAA) and other drugs), CAM (phytotherapy especially), and use of over-the-counter (OTC) drugs. If pharmacist considered an interaction or an intervention clinically relevant, the oncologist was notified. Then, a literature review was realized to identify the potential HDI (no interactions, precautions for use, contraindication). Among 201 pharmacist counseling sessions, it resulted in 104 interventions related to 46 HDI, 28 drug-drug interactions and 30 others (wrong dosage, omission…). To determine HDI, we review 73 medicinal plants which are used by our patients with cancer and 31 OAA. A total of 1829 recommendations were formulated about 59 (75%) medical plants and their interaction with an OAA. Herb-drug interactions should not be ignored by healthcare providers in their management of cancer patients in daily practice.


Assuntos
Antineoplásicos/efeitos adversos , Interações Ervas-Drogas , Neoplasias/tratamento farmacológico , Fitoterapia/efeitos adversos , Polimedicação , Idoso , Antineoplásicos/administração & dosagem , Humanos , Pessoa de Meia-Idade , Medicamentos sem Prescrição/administração & dosagem , Medicamentos sem Prescrição/efeitos adversos , Farmacêuticos , Preparações de Plantas/administração & dosagem , Preparações de Plantas/efeitos adversos , Estudos Prospectivos
19.
J Ethnopharmacol ; 236: 70-81, 2019 May 23.
Artigo em Inglês | MEDLINE | ID: mdl-30818007

RESUMO

ETHNOPHARMACOLOGICAL RELEVANCE: The issue of whether integrated treatment with conventional medicine (CM) and herbal medicine (HM) can reduce mortality in patients with polymyositis/dermatomyositis (PM/DM) had not been addressed. AIM OF THE STUDY: In this study, we investigated the effect of integrated therapy on mortality in a retrospective PM/DM cohort in the Taiwan National Health Insurance Research Database (NHIRD). MATERIALS AND METHODS: Patients with PM/DM were retrospectively enrolled from the PM/DM Registry of Catastrophic Illnesses cohort in the Taiwan NHIRD between 1997 and 2011. The patients were divided into an integrated medicine (IM) group that received CM and HM and a non-IM group that received CM alone. The Cox proportional hazards regression model and Kaplan-Meier method were used to evaluate the hazard ratio (HR) for mortality. RESULTS: Three hundred and eighty-five of 2595 patients with newly diagnosed PM/DM had received IM and 99 had received non-IM. The adjusted HR for mortality was lower in the IM group than in the non-IM group (0.42, 95% confidence interval 0.26-0.68, p < 0.001). The adjusted HR for mortality was also lower in the IM group that had received CM plus HM than in the group that received CM alone (0.48, 95% confidence interval 0.28-0.84, p < 0.05). The core pattern of HM prescriptions integrated with methylprednisolone, methotrexate, azathioprine, or cyclophosphamide to decrease mortality included "San-Qi" (Panax notoginseng), "Bai-Ji" (Bletilla striata), "Chen-Pi" (Citrus reticulata), "Hou-Po" (Magnolia officinalis), and "Dan-Shan" (Salvia miltiorrhiza). CONCLUSION: Integrated therapy has reduced mortality in patients with PM/DM in Taiwan. Further investigation of the clinical effects and pharmaceutical mechanism involved is needed.


Assuntos
Anti-Inflamatórios/uso terapêutico , Mortalidade/tendências , Fitoterapia/métodos , Preparações de Plantas/uso terapêutico , Polimiosite/tratamento farmacológico , Adolescente , Adulto , Idoso , Anti-Inflamatórios/administração & dosagem , Bases de Dados Factuais , Dermatomiosite/tratamento farmacológico , Dermatomiosite/mortalidade , Feminino , Humanos , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Síndromes Paraneoplásicas/tratamento farmacológico , Síndromes Paraneoplásicas/mortalidade , Preparações de Plantas/administração & dosagem , Polimiosite/mortalidade , Modelos de Riscos Proporcionais , Sistema de Registros , Estudos Retrospectivos , Taiwan/epidemiologia , Adulto Jovem
20.
Dermatol Ther ; 32(3): e12866, 2019 05.
Artigo em Inglês | MEDLINE | ID: mdl-30838736

RESUMO

The aim of this study is to review the efficacy of herbal and allopathic drugs used to manage and treat psoriasis. The review has been compiled using reference materials from major databases, Online Journals, Science Direct, Scopus, Open J Gate, Google Scholar and PubMed. Psoriasis is a common skin disease affecting 2-3% of the world's population. It is cosmetically debilitating and chronic disease, which occurs both in developing and developed countries. It can affect any part of the body, but the most common sites are the elbows, knees, and scalp. It is usually treated with synthetic medicine either given systematically or applied locally. The prescribed synthetic medicines used for the treatment of psoriasis are associated with severe side effects and complications, thus researchers around the world are trying to explore new, more effective, and safer drugs from natural resources. Medicinal plants are safe and efficacious, and most of the people all over the world rely on herbal medicine due to their easy availability, low cost, and efficacy for treating psoriasis. A number of medicinal plants having therapeutic potential with high efficacy are used in the treatment of psoriasis have been described. Moreover, studies should be conducted to isolate and investigate the mechanism of actions of phytochemicals responsible for anti-psoriasis potential.


Assuntos
Preparações de Plantas/administração & dosagem , Plantas Medicinais/química , Psoríase/tratamento farmacológico , Animais , Fármacos Dermatológicos/administração & dosagem , Fármacos Dermatológicos/efeitos adversos , Fármacos Dermatológicos/isolamento & purificação , Humanos , Fitoterapia/métodos , Preparações de Plantas/efeitos adversos
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