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2.
Bol. latinoam. Caribe plantas med. aromát ; 18(4): 392-410, jul. 2019. mapas, tab, graf
Artigo em Inglês | LILACS | ID: biblio-1008179

RESUMO

An ethnobotanical study was conducted with the aim to identify the medicinal plants used for the treatment of Diabetes mellitus (DM) in Sidi Bel Abbes region (Northwest Algeria). Sidi Bel Abbes, known for its diverse ecological habitats, such as mountains, steppe, lake, and fertile plains with diverse medicinal plants. The data was collected through questionnaire and interviews with inhabitants and traditional healers. The results obtained revealed that 33 plant species distributed in 20 genera belonging to 21 families for the treatment of DM were used. The most represented families were Lamiaceae, Asteraceae, Myrtaceae, Fabaceae and Lauraceae. Medicinal plants commonly used were Trigonella foenum-graecum, Olea europaea, Cinamomum cassia, Artemisia herba-alba, Lupinus albus, Juniperus communis, Rosmarinus officinalis, Prunus dulcis and Berberis vulgaris. The study revealed that, leaves, followed by seeds and stem bark were mostly used parts. Also, decoction and infusion were the most frequently used method of preparation. This study confirms that most people with Diabetes mellitus in the study areas rely on traditional medicine for their primary health care needs.


Se realizó un estudio etnobotánico con el objetivo de identificar las plantas medicinales utilizadas para el tratamiento de la Diabetes mellitus (DM) en la región de Sidi Bel Abbes (noroeste de Algeria). Sidi Bel Abbes, conocida por sus diversos hábitats ecológicos, como montañas, estepas, lagos y fértiles llanuras con plantas medicinales. Los datos se recopilaron mediante cuestionarios y entrevistas con habitantes y curanderos tradicionales. Los resultados obtenidos revelaron que 33 especies vegetales distribuidas en 20 géneros pertenecientes à 21 familias fueron utilizadas para el tratamiento de DM. Las familias más representadas fueron Lamiaceae, Asteraceae, Myrtaceae, Fabaceae y Lauraceae. Las plantas medicinales comúnmente utilizadas fueron Trigonella foenum-graecum, Olea europaea, Cinamomum cassia, Artemisia herba-alba, Lupinus albus, Juniperus communis, Rosmarinus officinalis, Prunus amygdalus y Berberis vulgaris. El estudio reveló que las hojas, seguidas de las semillas y la corteza de tallo, eran en su mayoría partes usadas. Sin embargo, la infusión y la decocción son el método de preparación más utilizado. El estudio reveló que las hojas, seguidas de las semillas y las partes del área, eran en su mayoría partes utilizadas. Tambien, la decocción y la infusión fueron los métodos de preparación más utilizado. Este estudio confirma que la mayoría de las personas con Diabetes mellitus en las áreas d'estudio dependen de la medicina tradicional para sus necesidades d'atenciónn primaria de la salud.


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Idoso , Plantas Medicinais , Folhas de Planta , Etnobotânica , Preparações de Plantas/uso terapêutico , Diabetes Mellitus/tratamento farmacológico , Sementes , Extratos Vegetais/uso terapêutico , Inquéritos e Questionários , Argélia , Medicina Tradicional
3.
Medicine (Baltimore) ; 98(30): e16466, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31348248

RESUMO

INTRODUCTION: In Korea, low back pain (LBP) which is occupation-related symptom is one of the major health issues owing to rapid industrialization. Even traditional Korean medicine has the long history in pain treatment, there still has been lack of supporting evidence on herbal prescription itself. Sogyeonghwalhyeol-tang, a Korean herbal medicine prescription, has been suggested as a medication for treating chronic LBP as well as work-related pains. OBJECTIVE: This study aims to evaluate the clinical efficacy and safety of herbal medicine, Sogyeonghwalhyeol-tang on work-related chronic LBP patients. METHOD: This trial is designed as a multicenter, randomized, controlled, clinical trial. Seventy-two participants who have chief complaint of LBP in Korean medicine rehabilitation center will be randomly assigned to ether Sogyeonghwalhyeol-tang group or placebo group with a ratio of 1:1. They will receive assigned drugs in 4 weeks and follow-up for 2 weeks. DISCUSSION: The result of this study will provide the valuable information for efficacy and safety of Sogyeonghwalhyeol-tang for patients with work-related chronic LBP.


Assuntos
Dor Lombar/tratamento farmacológico , Medicina Tradicional Coreana/métodos , Doenças Profissionais/tratamento farmacológico , Preparações de Plantas/uso terapêutico , Método Duplo-Cego , Humanos , Medição da Dor , Preparações de Plantas/administração & dosagem , Preparações de Plantas/efeitos adversos , Qualidade de Vida , República da Coreia
4.
Planta Med ; 85(13): 1044-1053, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31261419

RESUMO

This prospective, noninterventional, multicenter 12-wk study in women with overactive bladder investigated the effectiveness of Granu Fink femina, a herbal combination of seed oil from Uromedic pumpkin (cultivar of Cucurbita pepo), Rhus aromatica (fragrant sumach) bark extract, and Humulus lupulus (hop) cone extract in a clinical setting. Patients documented overactive bladder symptoms and quality of life using questionnaires as well as diaries recording day- and nighttime micturition frequencies, urine leakages during physical activity or at sneezing or coughing, and use of incontinence pads. The full analysis set included 117 women (age: 21 - 78 y). Urination frequency decreased significantly with improvement during daytime in 49, 71, and 77 (out of 99) patients and at night in 45, 63, and 70 (out of 100) patients after 1, 6, and 12 wk, respectively. The mean frequency of leakages and used pads decreased significantly from 0.9 leakages and 2.0 pads at baseline to 0.4 leakages and 1.4 pads after 12 wk. In all measured aspects of overactive bladder-related quality of life, (coping, concern, sleep, social), statistically significant improvement was reached after 1 wk, with further improvement at 6 and 12 wk. Ninety-nine percent of the physicians and 95.4% of the patients rated tolerability as "very good" or "good". Treatment with Granu Fink femina progressively improved overactive bladder symptoms and related quality of life with significant improvements already after 1 wk. Based on these effects and the observed excellent tolerability profile, Granu Fink femina may be considered a valuable therapeutic option for overactive bladder.


Assuntos
Cucurbita , Humulus , Fitoterapia/métodos , Preparações de Plantas/uso terapêutico , Rhus , Bexiga Urinária Hiperativa/tratamento farmacológico , Adulto , Idoso , Feminino , Medicina Herbária/métodos , Humanos , Pessoa de Meia-Idade , Preparações de Plantas/administração & dosagem , Adulto Jovem
5.
Planta Med ; 85(11-12): 934-940, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31216580

RESUMO

Malaria treatment and control have become increasingly difficult because of the spread of drug-resistant strains of Plasmodium falciparum and Plasmodium vivax. Thus, there is a continuous need to develop new combination therapies such as artemisinin-based combination therapies (ACTs) to contrast the emergence of resistant Plasmodium strains. Despite ACT has been recommended by the World Health Organization since 2001, its overall deployment in poor endemic areas is very slow, principally due to its high cost. In the malaria endemic areas, plant remedies are still widely used mostly without assurance of their efficacy and/or safety. A variety of widespread herbal drugs or natural products were already reported for their possible plasmodicidal activities, but the studies concerning their activity in combination with artemisinins are very scarce. The antimalarial activity of papaya is mostly anecdotal, and the present study is aimed at investigating the antiplasmodial activity of a decoction obtained by traditional recipe from the mature leaves of Carica papaya. The decoction was analyzed by HPLC-DAD-MS (high performance liquid chromatography coupled with diodoarray detector and mass spectrometry) showing the presence of caffeoyl derivatives and di- and triglycosides of flavonols. The extract was found to be active against P. falciparum 3D7 strains with a synergism in the presence of artemisinin. In vivo activity against the murine malaria model of Plasmodium berghei was disclosed both for the dried extract alone (250, 500, and 750 mg/kg/d) and for its combination with artesunate (250 mg/kg/d papaya plus 10 mg/kg/d artesunate). This combination displayed the greatest antimalarial activity in terms of reduction of parasitemia and prevention of recrudescence in animals recovered from the infection.


Assuntos
Antimaláricos/uso terapêutico , Artesunato/uso terapêutico , Carica/química , Malária/tratamento farmacológico , Fitoterapia/métodos , Folhas de Planta/química , Preparações de Plantas/uso terapêutico , Plasmodium berghei/efeitos dos fármacos , Animais , Antimaláricos/administração & dosagem , Artesunato/administração & dosagem , Cromatografia Líquida de Alta Pressão , Quimioterapia Combinada , Feminino , Camundongos , Camundongos Endogâmicos BALB C , Preparações de Plantas/administração & dosagem , Recidiva
6.
BMC Complement Altern Med ; 19(1): 115, 2019 Jun 03.
Artigo em Inglês | MEDLINE | ID: mdl-31159783

RESUMO

BACKGROUND: Skin burn wound is a notable medical burden worldwide. Rapid and effective treatment of burnt skin is vital to fasten wound closure and healing properly. Amniotic graft and Aloe vera are widely used as wound managing biomaterials. Sophisticated processing, high cost, availability, and the requirement of medics for transplantation limit the application of amnion grafts. We aim to prepare a novel gel from amnion combined with the Aloe vera extract for burn wound healing which overcome the limitations of graft. METHODS: Two percent human amniotic membrane (AM), Aloe vera (AV) and AM+AV gels were prepared. In vitro cytotoxicity, biocompatibility, cell attachment, proliferation, wound healing scratch assays were performed in presence of the distinct gels. After skin irritation study, second-degree burns were induced on dorsal region of Wistar rats; and gels were applied to observe the healing potential in vivo. Besides, macroscopical measurement of wound contraction and re-epithelialization; gel treated skin was histologically investigated by Hematoxylin and eosin (H&E) staining. Finally, quantitative assessment of angiogenesis, inflammation, and epithelialization was done. RESULTS: The gels were tested to be non-cytotoxic to nauplii and compatible with human blood and skin cells. Media containing 500 µg/mL AM+AV gel were observed to promote HaCaT and HFF1 cells attachment and proliferation. In vitro scratch assay demonstrated that AM+AV significantly accelerated wound closure through migration of HaCaT cells. No erythema and edema were observed in skin irritation experiments confirming the applicability of the gels. AV and AM+AV groups showed significantly accelerated wound closure through re-epithelialization and wound contraction with P < 0.01. Macroscopically, AM and AM+AV treated wound recovery rates were 87 and 90% respectively with P < 0.05. Histology analysis revealed significant epitheliazation and angiogenesis in AM+AV treated rats compared to control (P < 0.05). AM+AV treated wounds had thicker regenerated epidermis, increased number of blood vessels, and greater number of proliferating keratinocytes within the epidermis. CONCLUSION: We demonstrated that a gel consisting of a combination of amnion and Aloe vera extract has high efficacy as a burn wound healing product. Amniotic membrane combined with the carrier Aloe vera in gel format is easy to produce and to apply.


Assuntos
Âmnio , Queimaduras/tratamento farmacológico , Preparações de Plantas/uso terapêutico , Animais , Artemia , Linhagem Celular , Avaliação Pré-Clínica de Medicamentos , Feminino , Humanos , Neovascularização Fisiológica/efeitos dos fármacos , Fitoterapia , Preparações de Plantas/farmacologia , Ratos Wistar , Reepitelização/efeitos dos fármacos
7.
Niger J Clin Pract ; 22(6): 806-811, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31187766

RESUMO

Objective: Studies related to traditional practices and benefits have been usually performed among women. The literature regarding the traditional practices used by men in Turkey and around the world and their expected benefits is more limited. The aim of this study was to examine the traditional practices used by couples with fertility problems, affecting factors, expected benefits, and learning paths. Materials and Methods: The descriptive study was performed between May and July 2017 in Izmir, Turkey. In total, 151 women with infertility were included. The data related to the use of this practice by men were obtained from women partners. "Personal information form" and "traditional practices evaluation form" were used to obtain the data. Results: In total, 35.8% of the women and 25.8% of the men used traditional practices. The 24.4% of women and 52.1% of men used other practices such as figs, onion cures, and hacamat, whereas 18.2% of women and 14.9% of men used various herbs. The benefits they expected from traditional practices were facilitating conception, ensuring follicle development in women, increasing sperm count, and quality and facilitating conception in men. Overall, 37.0% of women learned of these practices from their friends, 30.7% of men learned from their partners, 20.4% of women and 20.6% of men learned from the internet. Conclusion: The couples in this study widely used traditional practices to solve fertility problems and learned from their friends and partners.


Assuntos
Terapias Complementares , Fertilidade , Infertilidade/terapia , Fitoterapia , Autocuidado/métodos , Adulto , Feminino , Amigos , Humanos , Comportamento de Busca de Informação , Internet , Masculino , Medicina Tradicional , Preparações de Plantas/uso terapêutico , Análise do Sêmen , Cônjuges , Turquia
8.
Ceska Slov Farm ; 68(1): 3-11, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31163962

RESUMO

Nowadays, oncological diseases are one of the most common causes of untimely death. Current therapy based on synthetic chemotherapeuties has a number of side-effects, and a resistance to this type of treatment is very common. For this reason, new substances without these effects are constantly sought. In this regard, natural products appear to be a promising source of new active compounds. This review aims to introduce cytostatics inspired by natural substances that are in clinical trials or are already in common use.


Assuntos
Antineoplásicos Fitogênicos/farmacologia , Neoplasias/tratamento farmacológico , Fitoterapia , Preparações de Plantas/uso terapêutico , Humanos , Plantas
9.
BMC Vet Res ; 15(1): 174, 2019 May 27.
Artigo em Inglês | MEDLINE | ID: mdl-31133058

RESUMO

BACKGROUND: Medicinal plants have been used traditionally since centuries for wound care and treatment of skin diseases both in human and animals. Skin diseases are one of the most common reasons for owners to take their dog to the veterinarian. The demands for treatment and prophylaxis of these diseases are broad. A wide range of bacteria including antibiotic-resistant bacteria can be involved, making the treatment challenging and bear an anthropo-zoonotic potential. The aim of this review is to systematically evaluate based on recent scientific literature, the potential of four medicinal plants to enrich the therapeutic options in pyoderma, canine atopic dermatitis, otitis externa, wounds and dermatophytosis in dogs. RESULTS: Based on four books and a survey among veterinarians specialized in phytotherapy, four medicinal plants were chosen as the subject of this systematic review: Calendula officinalis L. (Marigold), Hypericum perforatum L. agg. (St. John's Wort), Matricaria chamomilla L. (syn. Matricaria recutita L., Chamomile) and Salvia officinalis L. (Sage). According to the PRISMA statement through literature research on two online databases a total of 8295 publications was screened and narrowed down to a final 138 publications for which full-text documents were analyzed for its content resulting in a total of 145 references (21 clinical, 24 in vivo and 100 in vitro references). CONCLUSIONS: All four plants were proven to have antibacterial and antifungal effects of a rather broad spectrum including antibiotic-resistant bacteria. This makes them an interesting new option for the treatment of pyoderma, otitis externa, infected wounds and dermatophytosis. Marigold, St. John's Wort and Chamomile showed wound-healing properties and are thus promising candidates in line to fill the therapeutic gap in canine wound-healing agents. St. John's Wort and Chamomile also showed anti-inflammatory and other beneficial effects on healthy skin. Due to the wide range of beneficial effects of these medicinal plants, they should be taken into account for the treatment of dermatologic diseases in dogs at least in future clinical research.


Assuntos
Doenças do Cão/tratamento farmacológico , Preparações de Plantas/uso terapêutico , Dermatopatias/veterinária , Administração Tópica , Animais , Anti-Infecciosos/uso terapêutico , Cães , Fitoterapia/veterinária , Plantas Medicinais , Dermatopatias/tratamento farmacológico
10.
Complement Ther Med ; 43: 117-124, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30935518

RESUMO

OBJECTIVE: We performed a meta-analysis to evaluate the efficacy of barberry supplementation on plasma lipid concentration in adult population. METHODS: The search included PubMed, Scopus, ISI Web of Science, Cochrane library, and Google Scholar (up to October 2018) to identify randomized controlled trials (RCTs) investigating the effects of barberry supplementation on serum lipid parameters. Mean Difference (MD) was pooled using a random-effects model. RESULTS: Meta-analysis on 5 RCTs with 339 participants indicated that barberry supplementation significantly decreased the levels of total cholesterol (MD: -23.58 mg/dl, 95% CI: -31.00 to -16.16, P ≤ 0.001), triglyceride (MD: -29.16 mg/dl, 95% CI: -42.91 to -15.41, P ≤ 0.001), and low-density lipoprotein cholesterol (MD: -13.75 mg/dl, 95% CI: -19.31 to -8.20, P ≤ 0.001) whereas changes in high-density lipoprotein cholesterol (MD: 3.40 mg/dl, 95% CI: -0.06-6.87, P = 0.054) was not statistically significant. CONCLUSION: This systematic review and meta-analysis suggested the efficacy of barberry supplementation on lipid parameters. However, further large-scale studies are needed to confirm these results.


Assuntos
Berberis/química , Lipídeos/sangue , Preparações de Plantas/uso terapêutico , HDL-Colesterol/sangue , LDL-Colesterol/sangue , Suplementos Nutricionais , Humanos , Ensaios Clínicos Controlados Aleatórios como Assunto , Triglicerídeos/sangue
11.
Complement Ther Med ; 43: 92-101, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30935562

RESUMO

BACKGROUND AND AIMS: There is some evidence regarding the positive effects of cinnamon on metabolic status in patients with type 2 diabetes (T2DM). However, they are conflicting. In the present study, we aimed to systematically review the effects of cinnamon on glycemic status and anthropometric indices in patients with T2DM. METHODS: Five electronic databases including PubMed/Medline, SCOPUS, Web of Sciences, EMBASE, and the Cochrane library were searched until 31 February 2018 with no language limitation. Randomized clinical trials that examined the effects of cinnamon on at least fasting blood sugar (FBS) were included. Other glycemic parameters and anthropometric indices were also extracted. A random effects model with DerSimonian and Laird method was used for pooling the effect sizes. RESULTS: Finally, 18 studies were included in the meta-analysis. Supplementation with cinnamon reduced FBS by -19.26 mg/dL (95% CI: -28.08, -10.45; I2:96.5%; p = 0.0001) compared to placebo. However, the effects of cinnamon on HbA1C (-0.24%; 95% CI: -0.48, -0.01; I2: 76.8%, p = 0.0001), body weight (-0.46, 95%CI: -1.87, 2.30; I2:0%; p = 0.79), body mass index (WMD: -0.05 kg/m2; 95% CI: -0.52, 0.42; I2: 0%; p = 0.91), and waist circumference (WMD: -0.53 cm; 95% CI: -3.96, 2.81; I2: 0%; p = 0.66) were not significant. Additionally, cinnamon did not change the serum levels of insulin and insulin resistance significantly. CONCLUSION: Supplementation with cinnamon can reduce serum levels of glucose with no changes in other glycemic parameters and anthropometric indices. However, due to high heterogeneity findings should be interpreted with great caution.


Assuntos
Cinnamomum zeylanicum/química , Diabetes Mellitus Tipo 2/tratamento farmacológico , Diabetes Mellitus Tipo 2/metabolismo , Preparações de Plantas/uso terapêutico , Antropometria/métodos , Glicemia/efeitos dos fármacos , Índice de Massa Corporal , Peso Corporal/efeitos dos fármacos , Ensaios Clínicos como Assunto , Hemoglobina A Glicada/metabolismo , Humanos , Insulina/metabolismo , Resistência à Insulina/fisiologia , Ensaios Clínicos Controlados Aleatórios como Assunto , Circunferência da Cintura/efeitos dos fármacos
13.
Medicine (Baltimore) ; 98(11): e14526, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30882619

RESUMO

RATIONALE: Psoriasis is a common chronic, immune-mediated inflammatory skin disease. Here, we describe 2 patients who presented with psoriasis to illustrate the potential efficacy of Korean medicine treatment combined with phototherapy. PATIENT CONCERNS: A 33-year-old female (Case 1) and a 37-year-old male (Case 2) presented at the clinic with symptoms of itching, erythema, and scaliness. DIAGNOSIS: Both patients were diagnosed with psoriasis based on the locations of erythema, as well as the appearance of circumscribed scaly papules and plaques. INTERVENTIONS: Patients underwent 5 months (Case 1) and 8 months (Case 2) of treatments with acupuncture, herbal medicine, probiotics, and phototherapy. OUTCOMES: After treatment, the patients improved in Psoriasis Area and Severity Index score from 7 to 1.2 (Case 1), and 23.2 to 2.2 (Case 2). LESSONS: These outcomes suggest that Korean medicine therapies combined with phototherapy may be effective for resolution of psoriasis; however, further research is needed to confirm these findings.


Assuntos
Fototerapia , Fitoterapia , Psoríase/terapia , Terapia por Acupuntura , Adulto , Terapia Combinada , Feminino , Humanos , Testes de Função Hepática , Masculino , Medicina Tradicional Coreana , Preparações de Plantas/uso terapêutico , Probióticos/uso terapêutico , Índice de Gravidade de Doença
14.
BMC Complement Altern Med ; 19(1): 65, 2019 Mar 15.
Artigo em Inglês | MEDLINE | ID: mdl-30876425

RESUMO

BACKGROUND: Herbal medicine has become the panacea for many rural pregnant women in Ghana despite the modern western antenatal care which has developed in most parts of the country. To our knowledge, previous studies investigating herbal medicine use have primarily reported general attitudes and perceptions of use, overlooking the standpoint of pregnant women and their attitudes, and utilisation of herbal medicine in Ghana. Knowledge of herbal medicine use among rural pregnant women and the potential side effects of many herbs in pregnancy are therefore limited in the country; this qualitative study attempts to address this gap by exploring the perceptions of herbal medicine usage among pregnant women in rural Ghana. METHODS: A sample of 30, conveniently selected pregnant women, were involved in this study from April 11 to June 22, 2017. Data from three different focus group discussions were thematically analysed and presented based on an a posteriori inductive reduction approach. RESULTS: The main findings were that pregnant women used herbal medicine, most commonly ginger, peppermint, thyme, chamomile, aniseeds, green tea, tealeaf, raspberry, and echinacea leaf consistently throughout the three trimesters of pregnancy. Cultural norms and health beliefs in the form of personal philosophies, desire to manage one's own health, illness perceptions, and a holistic healing approach were ascribed to the widespread use of herbs. CONCLUSION: We recommend public education and awareness on disclosure of herbal medicine use to medical practitioners among pregnant women.


Assuntos
Fitoterapia , Preparações de Plantas , Gravidez/etnologia , Adulto , Estudos de Coortes , Feminino , Gana/etnologia , Medicina Herbária , Saúde Holística , Humanos , Fitoterapia/efeitos adversos , Fitoterapia/métodos , Fitoterapia/estatística & dados numéricos , Preparações de Plantas/efeitos adversos , Preparações de Plantas/uso terapêutico , Pesquisa Qualitativa , Adulto Jovem
15.
J Ethnopharmacol ; 236: 70-81, 2019 May 23.
Artigo em Inglês | MEDLINE | ID: mdl-30818007

RESUMO

ETHNOPHARMACOLOGICAL RELEVANCE: The issue of whether integrated treatment with conventional medicine (CM) and herbal medicine (HM) can reduce mortality in patients with polymyositis/dermatomyositis (PM/DM) had not been addressed. AIM OF THE STUDY: In this study, we investigated the effect of integrated therapy on mortality in a retrospective PM/DM cohort in the Taiwan National Health Insurance Research Database (NHIRD). MATERIALS AND METHODS: Patients with PM/DM were retrospectively enrolled from the PM/DM Registry of Catastrophic Illnesses cohort in the Taiwan NHIRD between 1997 and 2011. The patients were divided into an integrated medicine (IM) group that received CM and HM and a non-IM group that received CM alone. The Cox proportional hazards regression model and Kaplan-Meier method were used to evaluate the hazard ratio (HR) for mortality. RESULTS: Three hundred and eighty-five of 2595 patients with newly diagnosed PM/DM had received IM and 99 had received non-IM. The adjusted HR for mortality was lower in the IM group than in the non-IM group (0.42, 95% confidence interval 0.26-0.68, p < 0.001). The adjusted HR for mortality was also lower in the IM group that had received CM plus HM than in the group that received CM alone (0.48, 95% confidence interval 0.28-0.84, p < 0.05). The core pattern of HM prescriptions integrated with methylprednisolone, methotrexate, azathioprine, or cyclophosphamide to decrease mortality included "San-Qi" (Panax notoginseng), "Bai-Ji" (Bletilla striata), "Chen-Pi" (Citrus reticulata), "Hou-Po" (Magnolia officinalis), and "Dan-Shan" (Salvia miltiorrhiza). CONCLUSION: Integrated therapy has reduced mortality in patients with PM/DM in Taiwan. Further investigation of the clinical effects and pharmaceutical mechanism involved is needed.


Assuntos
Anti-Inflamatórios/uso terapêutico , Mortalidade/tendências , Fitoterapia/métodos , Preparações de Plantas/uso terapêutico , Polimiosite/tratamento farmacológico , Adolescente , Adulto , Idoso , Anti-Inflamatórios/administração & dosagem , Bases de Dados Factuais , Dermatomiosite/tratamento farmacológico , Dermatomiosite/mortalidade , Feminino , Humanos , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Síndromes Paraneoplásicas/tratamento farmacológico , Síndromes Paraneoplásicas/mortalidade , Preparações de Plantas/administração & dosagem , Polimiosite/mortalidade , Modelos de Riscos Proporcionais , Sistema de Registros , Estudos Retrospectivos , Taiwan/epidemiologia , Adulto Jovem
16.
Inflamm Res ; 68(5): 387-395, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30874868

RESUMO

OBJECTIVE: AST2017-01 is developed to be used for treatment and prevention of allergic diseases and composed of processed-Cordyceps militaris and processed-Rumex crispus. But, effect of AST2017-01 remains unclear in an allergic rhinitis (AR). So, this study aimed to explore the effects of AST2017-01 in ovalbumin (OVA)-induced AR animal model. METHODS: OVA-induced AR animals were orally administered AST2017-01 and chrysophanol, an active component of AST2017-01 for 10 days. RESULTS: In mice with AR, AST2017-01 and chrysophanol markedly decreased number of rubs, IgE, histamine, thymic stromal lymphopoietin, tumor necrosis factor-α, interleukin (IL)-1ß, IL-4, IL-5, and IL-13 in serum or nasal mucosa tissues. Moreover, activities and protein levels of caspase-1 were markedly diminished by oral administration of AST2017-01 and chrysophanol. Declines of macrophage inflammatory protein-2, intercellular adhesion molecules-1, eosinophil, and mast cells were also noted in nasal mucosa tissues of AST2017-01 and chrysophanol groups. CONCLUSIONS: Taken together, these findings indicate that AST2017-01 has an anti-allergic effect as a therapeutic agent or functional food for treating and preventing AR.


Assuntos
Antialérgicos/uso terapêutico , Cordyceps , Rinite Alérgica/tratamento farmacológico , Rumex , Animais , Antraquinonas/farmacologia , Antraquinonas/uso terapêutico , Antialérgicos/farmacologia , Caspase 1/imunologia , Citocinas/imunologia , Modelos Animais de Doenças , Eosinófilos/efeitos dos fármacos , Eosinófilos/imunologia , Feminino , Mastócitos/efeitos dos fármacos , Mastócitos/imunologia , Camundongos Endogâmicos BALB C , Mucosa Nasal/efeitos dos fármacos , Mucosa Nasal/imunologia , Neutrófilos/efeitos dos fármacos , Neutrófilos/imunologia , Ovalbumina , Preparações de Plantas/farmacologia , Preparações de Plantas/uso terapêutico , Rinite Alérgica/imunologia
17.
J Ethnopharmacol ; 235: 164-182, 2019 May 10.
Artigo em Inglês | MEDLINE | ID: mdl-30738117

RESUMO

ETHNOPHARMACOLOGICAL RELEVANCE: The Zeliangrong people with their yearlong experiences still depend on the medicinal plants for primary healthcare. Some of the medicinal plants used by the community exhibits established pharmacological activities which signify the importance of the traditional knowledge of the tribes. Besides, many other species traditionally used by the tribes assume to have pharmacological potentiality. AIM OF THE STUDY: The study aimed to identify the medicinally and pharmacologically important species with understanding the traditional healing practices and to compare medicinal plant knowledge among the informants of the three tribes under Zeliangrong group. MATERIAL AND METHODS: Data were collected by interviewing selected 27 herbal healers using modified semi-structured questionnaires. Identification and documentation of all the species have been made using standard taxonomic procedure. Ethnomedicinal uses of all the recorded species was analyzed with computation of the use reports for each species and Informant Consensus Factor. RESULTS: The study recorded 145 medicinal plants used in healing practices by the Zeliangrong tribes. Except 2 species, all are Angiospermic plants found mostly in wild condition. These medicinal plants are used for treating about 59 different health ailments categorized under 13 ICPC disease categories. Highest ICF (0.75) was found in Digestive disorder with 174 use reports for 44 plant species. Besides the established medicinal plants in the Indian System of medicine like Acorus calamus, Centella asiatica, Oroxylum indicum and Phyllanthus emblica, a number of other species like Ageratum conizoides, Blumeopsis flava, Clerodendrum glandulosum, Gynura cusimbua, Hedyotis scandens and Paederia foetida also has maximum use reports. Among the species with higher use reports, 2 species namely Clerodendrum glandulosum and Paederia foetida are exclusively used for the treatment of hypertension, and bone fracture and sprain respectively indicating their remarkable medicinal values and acceptability. Out of the total 145 species, only 24 are shared by all the three tribes with 11 species used for similar diseases. CONCLUSION: The medicinal plants with higher use reports can be evaluated for validation of pharmacological activities and their toxicity. The Indigenous Knowledge System of Zeliangrong community for herbal remedies may be of immense value in pharmacological experimentation particularly for the uses like malaria, health tonic, cancer, jaundice, hypertension and diabetes.


Assuntos
Conhecimentos, Atitudes e Prática em Saúde , Medicina Tradicional/métodos , Preparações de Plantas/uso terapêutico , Plantas Medicinais/química , Adulto , Idoso , Idoso de 80 Anos ou mais , Grupos Étnicos , Etnobotânica , Etnofarmacologia , Feminino , Humanos , Índia , Masculino , Pessoa de Meia-Idade , Fitoterapia/métodos , Inquéritos e Questionários
18.
Pesqui. bras. odontopediatria clín. integr ; 19(1): 4325, 01 Fevereiro 2019. tab, graf
Artigo em Inglês | LILACS, BBO - Odontologia | ID: biblio-997983

RESUMO

Objective: To determine the activity of anti-cancer and anti-proliferation of ethyl acetate fraction of ant nest plants (Myrmecodia pendans) in Burkitt's Lymphoma cancer cells. Material and Methods: The study was conducted in a pure laboratory experimental method using Burkitt's Lymphoma cancer cell culture. Gradual research begins with the determination, extraction and fractionation of ant nest plants, to test for proliferation barriers. Data analysis using two-way ANOVA followed by Post Hoc LSD test with a significance level of 95%. Pearson correlation test was conducted. Results: The results of testing the inhibition of Burkitt's Lymphoma cell proliferation with ethyl acetate extract treatment showed that there was inhibition of cell growth based on the concentration given, starting from the lowest concentration of 15.625 µg/mL. Likewise, the incubation time factor of 24, 48, and 72 hours showed that the longer the incubation time, the greater the inhibition of cell growth. Antiproliferation analysis of flavonoid ethyl acetate extract based on concentration and incubation time on absorption of optical density Burkitt's Lymphoma was statistically significant (p = 0.00). Conclusion: Ant nest ethyl acetate extract has the effect of proliferation inhibition on Burkitt's lymphoma cells.


Assuntos
Plantas Medicinais , Linfoma de Burkitt/patologia , Preparações de Plantas/uso terapêutico , Neoplasias/diagnóstico , Antineoplásicos/uso terapêutico , Formigas , Terapias Complementares/métodos , Análise de Variância , Escala Fujita-Pearson , Indonésia
19.
Post Reprod Health ; 25(1): 11-20, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30786797

RESUMO

OBJECTIVE: The aim of this overview was to evaluate the effectiveness of phytoestrogens on vaginal health and dyspareunia in peri- and post-menopausal women. MATERIAL AND METHODS: Three databases including MEDLINE, Scopus and the Cochrane Central Register of Controlled Trials were from inception to August 2017. RESULT: Two systematic reviews and 11 RCTs were included in the overview. According to the findings, isoflavones increased the maturation value and attenuated the vaginal atrophy in the post-menopausal women. Topical isoflavones had beneficial effects on the vaginal atrophy. Similar efficacy was found in Pueraria mirifica and conjugated estrogen cream on dryness ( p = 0.277), soreness ( p = 0.124) and irritation ( p = 0.469), as well as discharge ( p = 0.225) and dyspareunia ( p = 0.089). However, the conjugated estrogen cream was more effective compared to Pueraria mirifica ( p > 0.005) regarding maturation index improvement. Comparison of fennel 5% vaginal cream and placebo gel showed significant difference in superficial cells ( p < 0.01), parabasal cells ( p < 0.01) and intermediate cells ( p < 0.01), whereas no difference was found between the oral fennel and placebo in terms of superficial, parabasal and intermediate cells as well as Maturation value. Administration of 80 mg red clover oil had a significant effect on superficial ( p < 0.005), intermediate ( p < 0.005) and parabasal and vaginal dryness ( p < 0.005) compared to the placebo. Flaxseed had also a trivial effect on maturation value. Genistein had a more prominent effect on the genital score. The severity of dyspareunia decreased by 27%. CONCLUSION: Phytoestrogens have various effects based on administration route and type on the vaginal atrophy.


Assuntos
Dispareunia/tratamento farmacológico , Foeniculum , Isoflavonas/uso terapêutico , Fitoestrógenos/uso terapêutico , Pueraria , Vagina/patologia , Atrofia/tratamento farmacológico , Feminino , Linho , Géis , Humanos , Isoflavonas/administração & dosagem , Perimenopausa , Fitoestrógenos/administração & dosagem , Preparações de Plantas/uso terapêutico , Pós-Menopausa , Trifolium , Cremes, Espumas e Géis Vaginais/uso terapêutico
20.
J Ethnopharmacol ; 236: 366-392, 2019 May 23.
Artigo em Inglês | MEDLINE | ID: mdl-30772483

RESUMO

ETHNOPHARMACOLOGICAL RELEVANCE: There are insufficient safe and effective treatments for chronic pain in pets. In cases such as osteoarthritis there is no commercially available cure and veterinarians use NSAIDs to manage pain. Pet owners may have to plan for a lifetime of plant-based treatment for the conditions that lead to chronic pain in pets. Phytopharmacotherapies have the advantage of being less toxic, cheap or free, readily available, are more likely to be safe for long-term use and have the potential to reset the immune system to normal functioning. AIM OF THE STUDY: To examine the recently published medicinal plant research that matches unpublished data on ethnoveterinary medicines (EVM) used for pets in Canada (British Columbia) to see if the EVM data can provide a lead to the development of necessary drugs. MATERIALS AND METHODS: In 2003 semi-structured interviews were conducted with 60 participants who were organic farmers or holisitic medicinal/veterinary practitioners obtained using a purposive sample. A draft manual prepared from the data was then evaluated by participants at a participatory workshop that discussed the plant-based treatments. A copy of the final version of the manual was given to all research participants. In 2018, the recently published research matching the EVM data was reviewed to see if the EVM practices could serve as a lead for further research. RESULTS AND CONCLUSION: Medicinal plants are used to treat a range of conditions. The injuries treated in pets in British Columbia included abscesses (resulting from an initial injury), sprains and abrasions. Dogs were also treated with medicinal plants for rheumatoid arthritis, joint pain and articular cartilage injuries. More than 40 plants were used. Anal gland problems were treated with Allium sativum L., Aloe vera L., Calendula officinalis L., Plantago major L., Ulmus fulva Michx., Urtica dioica L. and Usnea longissima Ach. Arctium lappa, Hydrangea arborescens and Lactuca muralis were used for rheumatoid arthritis and joint pain in pets. Asthma was treated with: Linum usitatissimum L., Borago officinalis L., Verbascum thapsus L., Cucurbita pepo L., Lobelia inflata L., and Zingiber officinale Roscoe. Pets with heart problems were treated with Crataegus oxyacantha L., Cedronella canariensis (L.) Willd. ex Webb & Berth, Equisetum palustre L., Cypripedium calceolus L., Pinus ponderosa Douglas ex Lawson, Humulus lupulus L., Valeriana officinalis L., Lobelia inflata L., Stachys officinalis (L.) Trev., and Viscum album L. The following plants were used for epilepsy, motion sickness and anxiety- Avena sativa L., Valeriana officinalis, Lactuca muralis (L.) Fresen., Scutellaria lateriflora L., Satureja hortensis L., and Passiflora incarnata L. Plants used for cancer treatment included Phytolacca decandra, Ganoderma lucidum, Lentinula edodes, Rumex acetosella, Arctium lappa, Ulmus fulva, Rheum palmatum, Frangula purshiana, Zingiber officinale, Glycyrrhiza glabra, Ulmus fulva, Althea officinalis, Rheum palmatum, Rumex crispus and Plantago psyllium. Trifolium pratense was used for tumours in the prostate gland. Also used were Artemisia annua, Taraxacum officinale and Rumex crispus. This review of plants used in EVM was possible because phytotherapy research of the plants described in this paper has continued because few new pharmaceutical drugs have been developed for chronic pain and because treatments like glucocorticoid therapy do not heal. Phytotherapuetic products are also being investigated to address the overuse of antibiotics. There have also been recent studies conducted on plant-based functional foods and health supplements for pets, however there are still gaps in the knowledge base for the plants Stillingia sylvatica, Verbascum thapsus, Yucca schidigera and Iris versicolor and these need further investigation.


Assuntos
Doenças dos Animais/tratamento farmacológico , Dor Crônica/tratamento farmacológico , Fitoterapia/métodos , Preparações de Plantas/uso terapêutico , Plantas Medicinais/química , Animais , Animais Domésticos , Animais Selvagens , Colúmbia Britânica , Medicina Tradicional/efeitos adversos , Medicina Tradicional/métodos , Medicina Tradicional/tendências , Fitoterapia/efeitos adversos , Fitoterapia/tendências
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