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1.
BMJ Open ; 11(5): e043876, 2021 05 31.
Artigo em Inglês | MEDLINE | ID: mdl-34059510

RESUMO

INTRODUCTION: Family members have traditionally been relied on to provide informal care to older adults. However, social and demographic changes are resulting in rising numbers of kinless and isolated elderly who are unable to rely on familial caregiving and are without assistance in navigating complex systems of health and social services. Research examining this vulnerable subset of the elderly population, identified as elder orphans, is limited, particularly within the context of health and social care access. The aim of this scoping review is to map and report the evidence available in identifying barriers and facilitating factors in health and social care access and system navigation by elder orphans. METHODS AND ANALYSIS: Arksey and O'Malley's six-staged methodology framework will guide the conduct of this scoping review. The primary author will conduct a systematic search and an initial screen of titles and abstracts from six electronic databases (CINAHL Complete, ASSIA, Pubmed, Scopus, Web of Science and PsycINFO) from January 2005 to the date of commencement, to identify English language peer reviewed studies of various methodologies. Subsequently, two reviewers will independently screen a shorter list of studies for inclusion. We will also search the reference lists of eligible studies. Data from the selected studies will be extracted and charted by two independent reviewers. Findings will be summarised in a tabulated format and accompanied by a narrative synthesis. ETHICS AND DISSEMINATION: As the scoping review methodology aims to synthesise information from publicly available materials, this study does not require ethical approval. The finalised scoping review will be submitted for publication to a scientific journal. REGISTRATION: The present protocol has been registered with the Open Science Framework platform (registration ID: https://osf.io/7vjty/).


Assuntos
Crianças Órfãs , Idoso , Assistência à Saúde , Humanos , Revisão por Pares , Projetos de Pesquisa , Literatura de Revisão como Assunto , Apoio Social
2.
BMJ Open ; 11(5): e046064, 2021 05 31.
Artigo em Inglês | MEDLINE | ID: mdl-34059511

RESUMO

INTRODUCTION: Motor variability is an important feature when performing repetitive movement, and in asymptomatic people functional tasks are typically performed with variable motor patterns. However, in the presence of chronic non-specific low back pain (LBP), people often present with different motor control strategies than those without pain. Movement variability has been assessed using a wide range of variables, including kinetic and kinematic components of motion. This has resulted in a wide range of findings reported in the literature and some contradicting results. Therefore, the aim of this systematic review is to investigate whether the amount and structure of motor variability are altered in people with chronic non-specific LBP, during both repetitive non-functional and functional tasks. METHODS AND ANALYSIS: This protocol for a systematic review is informed by Cochrane guidelines and reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols. MEDLINE, EMBASE, CINAHL, ZETOC, Web of Science, PubMed and Scopus will be searched from their inception to December 2020 along with a comprehensive search of grey literature and key journals. Two independent reviewers will conduct the search, extract the data, assess risk of bias (using the Downs and Black Scale) for the included studies and assess overall quality of evidence based on Grading of Recommendations, Assessment, Development and Evaluation guidelines. Meta-analysis will be conducted if deemed appropriate. Alternatively, a narrative synthesis will be conducted and evidence summarised as an increase, decrease or no change in the motor variability of people with LBP compared with healthy controls. ETHICS AND DISSEMINATION: This study raises no ethical issues. Results will be submitted for publication in a peer review journal and presented at conferences. PROSPERO REGISTRATION NUMBER: CRD42020211580.


Assuntos
Dor Lombar , Viés , Fenômenos Biomecânicos , Humanos , Metanálise como Assunto , Movimento , Projetos de Pesquisa , Revisões Sistemáticas como Assunto
3.
BMJ Open ; 11(5): e047240, 2021 05 31.
Artigo em Inglês | MEDLINE | ID: mdl-34059514

RESUMO

INTRODUCTION: Goal planning is widely recognised as an integral part of mental health service delivery and an important element in supporting recovery. Goal planning identifies priorities for treatment through discussion and negotiation between service users and health practitioners. Goal planning enhances motivation, directs effort, and focuses the development of strategies and treatment options to improve recovery outcomes and promote service users' ownership of the recovery process. While goal planning is a common practice in mental health settings, evidence regarding its impact on treatment outcomes is lacking. This paper outlines a protocol for a systematic review that aims to explore the types of goals planned, experiences of service users and practitioners, and the effectiveness of goal planning as a mental health intervention. METHODS AND ANALYSIS: A systematic search will be conducted during March 2021 by searching Medline, CINAHL, Embase, Scopus and PsycINFO electronic databases to answer the following questions: (1) What types of goals are being developed within mental healthcare?; (2) What is the evidence for the effectiveness of goal planning on health and well-being for mental health service users?; (3) What are the experiences of mental health service users and their treating healthcare practitioners in relation to goal planning?; and (4) What are the barriers and facilitators to effective goal planning in mental health settings? Two independent researchers will screen the articles, selecting literature that meets criteria. All literature, regardless of study design that involves adult participants, with a mental illness and reporting on goal planning will be considered for inclusion. Data will be extracted from all eligible articles regardless of study design and summarised in a table. Appropriate quality assessment and data synthesis methods will be determined based on included study designs. ETHICS AND DISSEMINATION: No ethics approval is required. The results will be disseminated through peer-reviewed publications and conference presentations. PROSPERO REGISTRATION NUMBER: CRD42020220595.


Assuntos
Transtornos Mentais , Serviços de Saúde Mental , Adulto , Objetivos , Humanos , Transtornos Mentais/terapia , Saúde Mental , Motivação , Projetos de Pesquisa
4.
BMJ Open ; 11(5): e047627, 2021 05 31.
Artigo em Inglês | MEDLINE | ID: mdl-34059515

RESUMO

INTRODUCTION: Hangeshashinto has been employed for oral mucositis prevention in patients receiving cancer treatment, but the evidence has not been sufficiently robust to guide clinical decision-making. This study will therefore be undertaken to assess the effectiveness of Hangeshashinto for preventing oral mucositis in patients with cancer who are receiving treatment. METHODS AND ANALYSIS: The databases will include PubMed, Embase, the Cochrane Library, Chinese databases and Japanese databases. The literature will be searched from the databases' inception until May 2021. Other sources, such as potential grey literature, reference lists from included studies and relevant systematic reviews and conference papers, will also be searched. The primary outcome is the incidence of mucositis of any severity, and the secondary outcomes are interruptions to cancer treatment, oral pain and nutritional status. The risk of bias of eligible studies will be assessed using the Cochrane Collaboration's 'risk of bias' tool. Both the Q test and I2 statistic will be performed to assess statistical heterogeneity. If I2 >50%, sensitivity and subgroup analysis will be conducted. The quality of evidence will be rated according to the Grading of Recommendations, Assessment, Development and Evaluation approach. Egger's test will be used to assess reporting bias. ETHICS AND DISSEMINATION: This systematic review will evaluate only published data; therefore, ethical approval is not required. PROSPERO REGISTRATION NUMBER: CRD42020216145.


Assuntos
Neoplasias , Estomatite , Humanos , Metanálise como Assunto , Neoplasias/complicações , Dor , Projetos de Pesquisa , Estomatite/etiologia , Estomatite/prevenção & controle , Revisões Sistemáticas como Assunto
5.
BMJ Open ; 11(5): e049873, 2021 05 31.
Artigo em Inglês | MEDLINE | ID: mdl-34059517

RESUMO

INTRODUCTION: Hospitals commonly examine patient safety culture and other quality indicators to evaluate and improve performance in relation to quality and safety. A growing body of research has separately examined relationships between patient safety culture and patient experience on clinical outcomes and other quality indicators. However, there is a knowledge gap regarding the relationship between these two important domains. This article describes the protocol for a scoping review of published literature examining the relationship between patient safety culture and patient experience in hospital settings. The scoping review will provide an overview of research into the relationship between patient safety culture and patient experience in hospital contexts, map key concepts underpinning these domains and identify research gaps for further study. METHODS AND ANALYSIS: The scoping review will be conducted using the five stages of Arksey and O'Malley's framework: identify the research question; identify relevant studies; study selection; chart data; and collate, summarise and report the results. The inclusion criteria will be applied using the Population, Concept and Context Framework. Searches will be conducted in the CINAHL, Cochrane Library, ProQuest, MEDLINE, PsycINFO, Scopus and SciELO databases, without applying date range limits. Hand-searching of grey literature will also be performed to find relevant, non-indexed literature. Data will be extracted using a standardised data extraction form developed by the Joanna Briggs Institute. Both descriptive and thematic analyses will be undertaken to scope key concepts within the body of reviewed literature. ETHICS AND DISSEMINATION: This type of study does not require an ethics review. The results will be submitted for publication in a peer-reviewed journal and presented at conferences.


Assuntos
Segurança do Paciente , Projetos de Pesquisa , Hospitais , Humanos , Avaliação de Resultados da Assistência ao Paciente , Literatura de Revisão como Assunto , Gestão da Segurança
6.
Sensors (Basel) ; 21(9)2021 May 06.
Artigo em Inglês | MEDLINE | ID: mdl-34066410

RESUMO

Pig weight and body size are important indicators for producers. Due to the increasing scale of pig farms, it is increasingly difficult for farmers to quickly and automatically obtain pig weight and body size. Due to this problem, we focused on a multiple output regression convolutional neural network (CNN) to estimate pig weight and body size. DenseNet201, ResNet152 V2, Xception and MobileNet V2 were modified into multiple output regression CNNs and trained on modeling data. By comparing the estimated performance of each model on test data, modified Xception was selected as the optimal estimation model. Based on pig height, body shape, and contour, the mean absolute error (MAE) of the model to estimate body weight (BW), shoulder width (SW), shoulder height (SH), hip width (HW), hip width (HH), and body length (BL) were 1.16 kg, 0.33 cm, 1.23 cm, 0.38 cm, 0.66 cm, and 0.75 cm, respectively. The coefficient of determination (R2) value between the estimated and measured results was in the range of 0.9879-0.9973. Combined with the LabVIEW software development platform, this method can estimate pig weight and body size accurately, quickly, and automatically. This work contributes to the automatic management of pig farms.


Assuntos
Aprendizado Profundo , Animais , Estatura , Peso Corporal , Humanos , Redes Neurais de Computação , Projetos de Pesquisa , Suínos
7.
Sensors (Basel) ; 21(10)2021 May 14.
Artigo em Inglês | MEDLINE | ID: mdl-34069129

RESUMO

This paper presents a Kalman filter-based attitude estimation algorithm using a single body-mounted inertial sensor consisting of a triaxial accelerometer and triaxial gyroscope. The proposed algorithm has been developed for attitude estimation during dynamic conditions such as walking and running. Based on the repetitive properties of the velocity signal of human gait during walking, a novel velocity-aided observation is used as a measurement update for the filter. The performance has been evaluated in comparison to two standard Kalman filters with different measurement update methods and a smoother algorithm which is formulated in the form of a quadratic optimization problem. Whereas two standard Kalman filters give maximum 5 degrees in both pitch and roll error for short walking case, their performance gradually decrease with longer walking distance. The proposed algorithm shows the error of about 3 degrees in 15 m walking case, and indicate the robustness of the method with the same performance in 75 m trials. As far as the accuracy of the estimation is concerned, the proposed method achieves advantageous results due to its periodic error correction capability in both short and long walking cases at varying speeds. In addition, in terms of practicality and stability, with simple parameter settings and without the need of all-time data, the algorithm can achieve smoothing-algorithm-performance level with lower computational resources.


Assuntos
Marcha , Caminhada , Algoritmos , Humanos , Projetos de Pesquisa
8.
Stud Health Technol Inform ; 282: 315-332, 2021 Jun 04.
Artigo em Inglês | MEDLINE | ID: mdl-34085978

RESUMO

This paper presents the development of a digital generative design tool for residential building that integrates qualitative data from potential users of buildings. The central aim is to understand and challenge the inherent biases in the design process of architecture for mobility impaired users, whose experiences might be difficult to understand for designers who often move around and use buildings without any difficulty. Although Universal Design promotes designed environments that are more sensitized with the diverse difference of individuals, the most of design generating tools are based on empirically deducted human needs, objectifying the people or seeing them as useful in simply validating design ideas. There is a clear distance in between the real needs and wishes of wheelchair users and what architects imagine when designing. Mixed-methods - expert interview, literature review and data analysis of disability blogs - are used to collect and analyse wheelchair users' experience. Accumulated qualitative data is, then, used as guiding input for the development of an explorative generative model that effectively produces large number of floor plans for residential architecture. The developed generative model effectively selects floor plans that correspond with challenges described by the wheelchair users. The selected floor plans become informed starting points for spatial planning, which can guide architects to produce new and unexpected design solutions that are more sensitised to wheelchair users' experience. The application of generative design tools in early stages of design tasks can help architects to understand users' needs and wishes, and thus challenge biased assumptions about wheelchair users' experiences. And yet, further research needs to be conducted in order to progress the system: additional user data and new design objectives can give rise to new hypothesis and allow the system to be more precise, responding to the complex reality of disabled people in their everyday lives.


Assuntos
Pessoas com Deficiência , Cadeiras de Rodas , Humanos , Pesquisa Qualitativa , Projetos de Pesquisa
9.
Food Chem ; 358: 129817, 2021 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-33940302

RESUMO

In this paper, a green and inexpensive air-assisted natural deep eutectic solvent-based solidified homogeneous liquid phase microextraction procedure was optimized for extraction of patulin in fruit juice and dried fruit samples using experimental design prior to its spectrophotometric determination. Four different natural deep eutectic solvent were prepared and applied to ensure efficient, and selective extraction of patulin. The significant variables including Zn(II) amount, cooling time, pH and amount of natural deep eutectic solvent were optimized by using central composite design. Under optimized conditions, working range was 10-750 µg L-1 with 0.9996 of correlation coefficient. Detection limit and preconcentration factor were 3.5 µg L-1 and 150, respectively. The repeatability and reproducibility precision were in the range of 3.2-4.6% and 4.3-5.6% respectively. Recoveries ranging from 94% to 104% proved the accuracy of the method. The optimized method was successfully applied to the extraction and identification of patulin in the selected samples.


Assuntos
Sucos de Frutas e Vegetais , Frutas/química , Microextração em Fase Líquida/métodos , Patulina/isolamento & purificação , Química Computacional , Química Verde , Concentração de Íons de Hidrogênio , Limite de Detecção , Reprodutibilidade dos Testes , Projetos de Pesquisa , Solventes/química , Espectrofotometria Ultravioleta , Fatores de Tempo
10.
J Clin Psychiatry ; 82(1)2021 02 18.
Artigo em Inglês | MEDLINE | ID: mdl-33999541

RESUMO

Questionable research practices (QRPs) in the statistical analysis of data and in the presentation of the results in research papers include HARKing, cherry-picking, P-hacking, fishing, and data dredging or mining. HARKing (Hypothesizing After the Results are Known) is the presentation of a post hoc hypothesis as an a priori hypothesis. Cherry-picking is the presentation of favorable evidence with the concealment of unfavorable evidence. P-hacking is the relentless analysis of data with an intent to obtain a statistically significant result, usually to support the researcher's hypothesis. A fishing expedition is the indiscriminate testing of associations between different combinations of variables not with specific hypotheses in mind but with the hope of finding something that is statistically significant in the data. Data dredging and data mining describe the extensive testing of relationships between a large number of variables for which data are available, usually in a database. This article explains what these QRPs are and why they are QRPs. This knowledge must become widespread so that researchers and readers understand what approaches to statistical analysis and reporting amount to scientific misconduct.


Assuntos
Pesquisa Biomédica/normas , Interpretação Estatística de Dados , Mineração de Dados/normas , Transtornos Mentais/tratamento farmacológico , Avaliação de Resultados em Cuidados de Saúde/normas , Psiquiatria/normas , Psicofarmacologia/normas , Má Conduta Científica , Humanos , Projetos de Pesquisa/normas
11.
J Couns Psychol ; 68(3): 271-285, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34043374

RESUMO

While counseling psychologists made substantial proposals to advance qualitative research since the special issue on related methods was published 15-years ago (Haverkamp, Morrow, & Ponterotto, 2005), the field continues to demonstrate an overreliance on quantitative methods. Though important for producing knowledge we can depend on, excessive use of these methods poses a barrier for counseling psychologists to address the needs of the communities that are at the core of our discipline's values-those who are marginalized and underserved in society. In alignment with our values of social justice, advocacy, and empowerment, we propose counseling psychologists adopt a methodology within a critical paradigm to better address issues of inequality and inequity when working with underrepresented communities, such as digital storytelling. Rooted in a movement to increase access to art for marginalized communities in the 1970s and 1980s, digital storytelling is an arts-based research methodology that captures first-person narrated accounts of peoples' lives through the use of stories, photos, and videos, and empowers communities to be a part of research to create social change. We provide recommendations for using digital storytelling in counseling psychology research as outlined through 5 phases, including Phase I) digital storytelling's critical paradigm, Phase II) project development, Phase III) implementation, Phase IV) data analysis, and Phase V) dissemination. While doing so, we draw on examples from 2 digital storytelling projects we are familiar with, Immigrant Stories and OrigiNatives, providing a framework for a digital frontier in counseling psychology research. (PsycInfo Database Record (c) 2021 APA, all rights reserved).


Assuntos
Aconselhamento , Narração , Psicologia , Projetos de Pesquisa , Emigrantes e Imigrantes/psicologia , Humanos , Pesquisa Qualitativa , Justiça Social
12.
J Couns Psychol ; 68(3): 286-298, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34043375

RESUMO

Qualitative story completion (SC) research involves the novel qualitative application of a technique previously used in quantitative research and clinical assessment, in which participants write stories in response to a story "stem" designed by the researcher. The resulting stories are analyzed to identify patterns of meaning using conventional qualitative analytic approaches such as thematic analysis. In place of the more typical self-report methods used in qualitative research, such as interviews or focus groups, the method provides a categorically different way to explore a topic, one which can offer new understandings to counseling psychology researchers. In particular, SC's capacity to illuminate social discourses makes it particularly useful for understanding the potential ways in which socially marginalized populations are understood in therapeutic spaces as well as for understanding how clients of all kinds may make sense of therapeutic interactions. This article provides an introduction to qualitative SC, explaining the method and its origins, and offering practical guidance about how to use it. The method is illustrated with examples from the existing SC literature and a hypothetical study focused on understandings of mental health difficulties in the workplace. (PsycInfo Database Record (c) 2021 APA, all rights reserved).


Assuntos
Aconselhamento , Pesquisa Qualitativa , Projetos de Pesquisa , Humanos , Saúde Mental , Local de Trabalho/psicologia
13.
J Couns Psychol ; 68(3): 331-343, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34043377

RESUMO

Qualitative research in counseling psychology in the last 2 decades has been characterized by the introduction and use of a range of methods and corresponding paradigms and conceptual frameworks. The action-project research method, described and updated in this article, is based on an understanding of human action as goal-directed and enacted in context: contextual action theory. We summarize this framework, prior to describing the method's procedures for conceptualizing research problems and questions, collecting and analyzing data from dyads of participants, and presenting research findings. We also discuss recent adaptations to the procedures and how the method addresses core issues in counseling psychology; that is, methodological integrity, culture, ethics, and power. We proceed to describe how the method relates to other qualitative methods and the kinds of research questions asked by the discipline and how the action-project method connects to professional practice issues. (PsycInfo Database Record (c) 2021 APA, all rights reserved).


Assuntos
Aconselhamento , Psicologia , Pesquisa Qualitativa , Projetos de Pesquisa , Aconselhamento/métodos , Humanos , Motivação , Psicologia/métodos , Tamanho da Amostra
14.
J Couns Psychol ; 68(3): 344-356, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34043378

RESUMO

Building on the conceptual foundation of articles published in the 2005 volume of the Journal of Counseling Psychology on the qualitative turn in Counseling Psychology, we write to introduce and reflect on Critical Participatory Action Research (CPAR) as an intersectional approach to knowledge production by psychologists researching alongside individuals, communities, and movements dedicated to social justice. We open with a brief review of the origins of CPAR and the epistemological commitments of this approach to inquiry. We then explore why and how participation matters, and the delicate dynamics of CPAR through various phases of research: putting together a research team, crafting research questions and design, selecting methods, sampling, participatory analyses of qualitative and quantitative material, and figuring out how to produce and circulate findings in ways accountable to the community/movement of interest. The second half of the article offers a slow journey into one CPAR project, What's Your Issue?, a multigenerational, national, participatory survey designed by and for LGBTQIA+ youth, with an emphasis on the participation and representation of youth of color. We write this article for scholars, practitioners, activists, educators, and students to make visible why participation is so crucial to social justice research; that "no research on us, without us" is both scientifically and ethically valid, and how mixed methods research with LGBTQIA+ and gender-expansive youth can open new horizons for theory, methods, and action. (PsycInfo Database Record (c) 2021 APA, all rights reserved).


Assuntos
Pesquisa sobre Serviços de Saúde , Conhecimento , Projetos de Pesquisa , Justiça Social , Adolescente , Adulto , Idoso , Pesquisa Participativa Baseada na Comunidade , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Adulto Jovem
15.
J Couns Psychol ; 68(3): 357-370, 2021 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-34043379

RESUMO

This article articulates principles and practices that support methodological integrity in relation to critical qualitative research. We begin by describing 2 changes that have occurred in psychological methods over the last 15 years. (a) Building on foundational work advocating for epistemological pluralism, guidelines on how to design, review, and report qualitative and mixed methods have been advanced to support methodological integrity in keeping with a diversity of researchers' aims and approaches. (b) There has been an increased use of critical epistemological perspectives and critical methods. In light of these changes, the current article puts forward principles to support critical qualitative researchers when considering methodological rigor and when formulating rationales to support their methods in the journal article review process. Illustrating the principles with an example of critical research, the article describes common problems and issues in the research design process that can be considered in order to strengthen the returns of critical studies. Recommendations are made for editors and reviewers on how to conduct reviews of critical qualitative research, and pressing concerns for publishing critical qualitative research are detailed. (PsycInfo Database Record (c) 2021 APA, all rights reserved).


Assuntos
Pesquisa Qualitativa , Projetos de Pesquisa , Pesquisadores , Humanos , Literatura de Revisão como Assunto
16.
BMJ Open ; 11(5): e043064, 2021 05 21.
Artigo em Inglês | MEDLINE | ID: mdl-34020972

RESUMO

INTRODUCTION: Several systematic reviews and meta-analysis indicate that acupuncture and related therapies may be a valuable adjunctive technique to pharmacological interventions for pain management of postherpetic neuralgia (PHN). However, the robustness of the results of these studies has not been evaluated. The aim of this proposed umbrella review is to provide more reliable evidence of the effectiveness of acupuncture therapy for PHN based on medical references for healthcare decision makers. METHODS AND ANALYSIS: PubMed, EMBASE, The Cochrane Library, Web of Science, Chinese BioMedical Literature Database, VIP Database for Chinese Technical Periodicals, China National Knowledge Infrastructure and Wan fang Database will be used to retrieve reviews. The time of publication will be limited from inception to March 2021. Two reviewers will screen all retrieved articles independently to identify their eligibility and extract the data. The quality will be assessed independently by two trained reviewers using Assessment of Multiple Systematic Reviews-2 for methodological quality, Risk of Bias in Systematic Review for level of bias, Preferred Reporting Items for Systematic Reviews and Meta-Analysis for reporting quality and Grading of Recommendations Assessment, Development and Evaluation for the quality of evidence. Any disagreements will be settled by discussion or the involvement of a third reviewer. ETHICS AND DISSEMINATION: The protocol of this review does not require ethical approval because the research will be based on publicly available data. The findings will be disseminated through publication in peer-reviewed international journals or presentation in academic conference. PROSPERO REGISTRATION NUMBER: CRD42020173341. REPORTING CHECKLIST: PRISMA-P, 2015.


Assuntos
Terapia por Acupuntura , Neuralgia Pós-Herpética , China , Humanos , Metanálise como Assunto , Neuralgia Pós-Herpética/terapia , Manejo da Dor , Projetos de Pesquisa , Literatura de Revisão como Assunto
17.
BMJ Open ; 11(5): e043959, 2021 05 21.
Artigo em Inglês | MEDLINE | ID: mdl-34020973

RESUMO

INTRODUCTION: Intestinal barrier function is dependent on the structure and function of intestinal epithelial cells and paracellular pathway. The derangement of the intestinal barrier function can originate from conditions involving local and systemic chronic inflammation and metabolic diseases such as obesity and metabolic disorders. This study aims to describe a systematic review protocol investigating if obesity with or without metabolic syndrome is associated with an altered intestinal barrier function. METHODS AND ANALYSIS: This protocol is guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols. The databases to be searched are PubMed, Embase, Scopus, Science Direct and Web of Science. The systematic review will include original articles with adults and the elderly, who present obesity with or without metabolic syndrome, that address the intestinal barrier function. Two independent reviewers will perform study selection, data extraction and methodological quality assessment. Key information will be tabulated and a narrative synthesis will be conducted. The Grading of Recommendation, Assessment, Development and Evaluation framework will be used to assess the quality of evidence concerning the associations between intestinal barrier function and obesity with or without metabolic syndrome. The present protocol will assist in producing a systematic review that addresses if obesity with or without metabolic syndrome alters intestinal barrier function. ETHICS AND DISSEMINATION: No ethical statement will be required. The results will be disseminated through a peer-reviewed publication and conference presentations. PROSPERO REGISTRATION NUMBER: CRD42020178658.


Assuntos
Síndrome Metabólica , Adulto , Idoso , Humanos , Obesidade/complicações , Projetos de Pesquisa , Revisões Sistemáticas como Assunto
18.
Nursing ; 51(2): 62-65, 2021 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-33953103

RESUMO

ABSTRACT: To support evidence-based nursing practice, the authors provide guidelines for appraising research based on quality, quantity, and consistency. This article, the second of a three-part series, focuses on nonexperimental research designs.


Assuntos
Enfermagem Baseada em Evidências , Projetos de Pesquisa , Guias como Assunto , Humanos
19.
Zhongguo Zhong Yao Za Zhi ; 46(7): 1706-1710, 2021 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-33982473

RESUMO

To sort out the key points in "PICOS" design of clinical trial scheme for influenza, and optimize the clinical trial scheme of Chinese patent medicine in the treatment of influenza by strictly following the principle of evidence-based medicine, focusing on the clinical practice of the disease, and highlighting the characteristics of traditional Chinese medicine. "The design of a randomized, double-blind, positive parallel control study of a certain herbal preparation for the treatment of non-severe influenza" was taken as an example in this study, and the key points in the clinical trial design of Chinese patent medicine for the treatment of influenza were specifically discussed from six aspects, including the type of study, object of study, intervention measures, control measures, outcome indicators and frequently asked questions in test design. From methodological suggestions, in the design scheme of clinical trial on efficacy and safety of Chinese patent medicine in the treatment of influenza, the randomized controlled study should be the first choice for type of study; the inclusion criteria should define both the diagnostic criteria of Western medicine and the syndromes of traditional Chinese medicine(TCM); the exclusion criteria should include a comprehensive list of confounding factors and special circumstances lea-ding to bias in the study results; the interventions should be based on a well-defined dosing programme; internationally recognized positive drugs or guidelines should be used as control measures, with median antipyretic time as the main outcome indicator. For the evalua-tion of curative effect, disease symptom scale can be set, and the TCM syndrome scoring scale was carefully used in this study, with time nodes set for the efficacy evaluation standard. The full name of the drugs should be written in the regulations on combined drug use and prohibited drug use.


Assuntos
Medicamentos de Ervas Chinesas , Influenza Humana , Método Duplo-Cego , Medicamentos de Ervas Chinesas/uso terapêutico , Medicina Baseada em Evidências , Humanos , Influenza Humana/tratamento farmacológico , Medicina Tradicional Chinesa , Ensaios Clínicos Controlados Aleatórios como Assunto , Projetos de Pesquisa , Resultado do Tratamento
20.
BMC Fam Pract ; 22(1): 91, 2021 05 12.
Artigo em Inglês | MEDLINE | ID: mdl-33980165

RESUMO

BACKGROUND: The implementation of lockdowns in the UK during the COVID-19 pandemic resulted in a system switch to remote primary care consulting at the same time as the incidence of domestic violence and abuse (DVA) increased. Lockdown-specific barriers to disclosure of DVA reduced the opportunity for DVA detection and referral. The PRECODE (PRimary care rEsponse to domestic violence and abuse in the COvid-19 panDEmic) study will comprise quantitative analysis of the impact of the pandemic on referrals from IRIS (Identification and Referral to Improve Safety) trained general practices to DVA agencies in the UK and qualitative analysis of the experiences of clinicians responding to patients affected by DVA and adaptations they have made transitioning to remote DVA training and patient support. METHODS/DESIGN: Using a rapid mixed method design, PRECODE will explore and explain the dynamics of DVA referrals and support before and during the pandemic on a national scale using qualitative data and over four years of referrals time series data. We will undertake interrupted-time series and non-linear regression analysis, including sensitivity analyses, on time series of referrals to DVA services from routinely collected data to evaluate the impact of the pandemic and associated lockdowns on referrals to the IRIS Programme, and analyse key determinants associated with changes in referrals. We will also conduct an interview- and observation-based qualitative study to understand the variation, relevance and feasibility of primary care responses to DVA before and during the pandemic and its aftermath. The triangulation of quantitative and qualitative findings using rapid analysis and synthesis will enable the articulation of multiscale trends in primary care responses to DVA and complex mechanisms by which these responses have changed during the pandemic. DISCUSSION: Our findings will inform the implementation of remote primary care and DVA service responses as services re-configure. Understanding the adaptation of clinical and service responses to DVA during the pandemic is crucial for the development of evidence-based, effective remote support and referral beyond the pandemic. TRIAL REGISTRATION: PRECODE is an observational epidemiologic study, not an intervention evaluation or trial. We will not be reporting results of an intervention on human participants.


Assuntos
/epidemiologia , Violência Doméstica/prevenção & controle , Atenção Primária à Saúde/organização & administração , Encaminhamento e Consulta , Projetos de Pesquisa , Feminino , Humanos , Análise de Séries Temporais Interrompida , Masculino , Pandemias , Desenvolvimento de Programas , Pesquisa Qualitativa , Reino Unido/epidemiologia
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