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1.
Ann Palliat Med ; 10(9): 9870-9878, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-34628913

RESUMO

BACKGROUND: Prostatitis seriously endangers the health of men. While they have been widely used in recent years, there remains a lack of systematic evaluation of the clinical efficacy of α-receptor blockers (α-RBs)/α-adrenergic receptor blockers (α-ARBs) in its treatment. Based on this, this study was developed to systematically evaluate the clinical effect of α-ARB in the treatment of prostatitis. METHODS: Randomized controlled trials (RCTs) studying α-RBs or α-ARBs, placebos, or other measures to treat prostatitis were searched in Cochrane Library, PubMed, Embase, and CBM databases from establishment to December 2020. The quality of included articles was evaluated using the Cochrane System Review Manual and Jadad tools, and a meta-analysis was performed using Review Manager 5.3 software. RESULTS: A total of six articles meeting the requirements were found and included 450 patients. Meta-analysis showed that the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) score [mean difference (MD) =-1.76, 95% confidence interval (CI): (-3.35 to -0.17), and P=0.03], pain score [MD =-2.24, 95% CI: (-3.65 to -0.83), and P=0.002], voiding symptom score [MD =-1.21, 95% CI: (-2.06 to -0.35), and P=0.006], and quality of life score [MD =-1.40, 95% CI: (-1.48 to -1.33), and P<0.00001] for patients in the experimental group were lower in contrast to those in the control group after the treatment. DISCUSSION: The use of α-ARB could significantly improve the treatment effect of patients with prostatitis and improve their quality of life.


Assuntos
Terapia por Acupuntura , Prostatite , Doença Crônica , Humanos , Masculino , Prostatite/tratamento farmacológico , Receptores Adrenérgicos alfa , Resultado do Tratamento , Estados Unidos
2.
Urologiia ; (4): 53-60, 2021 Sep.
Artigo em Russo | MEDLINE | ID: mdl-34486275

RESUMO

INTRODUCTION: Chronic prostatitis is the most common urological disease. The morphological outcome of chronic inflammation is sclerosis, leading to the loss of functional active tissue. Venous congestion of the small pelvis can act as a trigger factor in the development of prostate sclerosis. Venotonics in combination with antioxidants may be considered for organoprotection of the prostate in pelvic varicose veins. PURPOSE: to evaluate the protective effect of an antioxidant, venotonic and their combination on the process of formation of connective tissue in the prostate gland against the background of pelvic varicose veins in a chronic experiment. MATERIALS AND METHODS: The experiment was carried out on a proven model of chronic venous congestion of the small pelvis and was carried out on 64 sexually mature rabbits weighing 2.6-3.2 kg. 5 groups have been identified. In the first group (n=15), an assessment of the effect of isolated antioxidant (resveratrol) was carried out. In the second group (n=15), an assessment of the effect of isolated venotonic (diosmin) was studied. In the third group (n=15), the effect of a combination of an antioxidant (resveratrol) and venotonic (diosmin) was evaluated. An aqueous solution of the preparations was injected daily for 180 days. In the fourth group (n=15), changes in the prostate were assessed against the background of venous congestion without exposure. In the fifth group (n=4), animals performed to provide data on normal anatomy. The animals were taken out of the experiment at 30, 90, 180 days. Prostate tissue was collected for histological examination and morphometry. In prostate samples, the concentration of hydroxyproline, a marker of connective tissue development, was investigated. RESULTS: the isolated administration of resveratrol, as well as diosmin, does not sufficiently compensate for the changes in the hemodynamics of the small pelvis and the toxic effect of metabolic products. With morphometry on day 180, the proportion of glandular tissue in the gland / fibrosis ratio was significantly higher, and fibrosis was lower in Group 3 (79.36 / 9.08 (p<0.01) than in Group 1 (63.1 / 22.74) and Group 2 (65.52 / 21.0) .Quantitative study of hydroxyproline showed lower concentrations in the samples of Group 3 18.44 mg% (p<0.01), relative to Groups 1 and 2 (39.7 and 34.44 mg%) There were no statistically significant differences in the studied parameters between Groups 1 and 2. CONCLUSION: the use of a combination of diosmin and resveratrol against the background of chronic venous hyperemia allowed, in the course of the presented experiment, to reduce the lesion volume and the growth of fibrous tissue in the prostate gland. The approach itself requires further study.


Assuntos
Diosmina , Prostatite , Varizes , Animais , Humanos , Masculino , Pelve , Coelhos , Varizes/tratamento farmacológico
3.
Urologiia ; (4): 68-72, 2021 Sep.
Artigo em Russo | MEDLINE | ID: mdl-34486277

RESUMO

INTRODUCTION: Chronic recurrent bacterial prostatitis (CRPD) is an urgent problem of modern urology and andrology. OBJECTIVE: To study the immunological features of the secretion of the prostate by electron microscopy in patients with chronic recurrent bacterial prostatitis. MATERIALS AND METHODS: The analysis of the morphometric study of neutrophils in the secretion of the prostate was carried out in 90 patients with chronic bacterial prostatitis, who were divided into two groups. Group I (study) (n=51) with chronic recurrent bacterial prostatitis (CRBP) and group II (control) (n=39) with chronic primary diagnosed bacterial prostatitis (CPDBP). RESULTS: At electron microscopy of ALE in most patients with CRBP of the group, the cytological picture of ALE was represented by inactive neutrophils with pathology of phagocytosis. The cells are of the correct rounded shape, without pseudopodia, with light cytoplasm. The cytological picture of ALE in CPDBP is characterized by the absence of impaired local immunity. The normal process of phagocytosis is recorded, where many pseudopodia of the segmented neutrophil completely complete the process of opsonization of microorganisms in the area of the inflammatory process. CONCLUSIONS: In patients with CRBP, in 100% of cases, dysfunction of immunocompetent prostate cells was noted, which is the basis for the appointment of immunoactive therapy for CRBP.


Assuntos
Prostatite , Doença Crônica , Eletrônica , Humanos , Masculino , Microscopia Eletrônica
4.
Urologiia ; (4): 138-144, 2021 Sep.
Artigo em Russo | MEDLINE | ID: mdl-34486287

RESUMO

A review of the literature on the urgent problem of urology, which is therapy of chronic prostatitis (CP) is presented. Despite numerous studies dedicated to the prevention and treatment of CP, it has not yet been possible to reduce the CP incidence. Therapeutic approaches aimed at improving the quality of life are not always effective due to the lack of a clear understanding of the etiology and pathogenesis of the disease. Leading Russian urologists recommend introducing into the complex therapy of CP a domestic drug from the cytomedin, namely Vitaprost, which causes a significant decrease in the severity of trophic disorders, inflammatory and congestive processes, improves microcirculation in the prostate, stimulates cellular and humoral immunity, all of which increase the effectiveness of CP therapy.


Assuntos
Prostatite , Urologia , Doença Crônica , Humanos , Masculino , Prostatite/tratamento farmacológico , Qualidade de Vida , Federação Russa
5.
Wiad Lek ; 74(8): 1834-1838, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34537729

RESUMO

OBJECTIVE: The aim: Study of hemodynamics of the prostate and evaluation of the ef f ectiveness of extracorporeal shock wave therapy (ESWT) in the complex treatment of patients with chronic prostatitis with non-inf l ammatory chronic pelvic pain syndrome (NCPPS), (NIH III B). PATIENTS AND METHODS: Materials and methods: There were 63 patients with NCPPS aged 29 to 45 years, with a disease duration of more than 3 years and low ef f i cacy of treatment against the background of standard therapy. All patients received standard therapy according to the clinical protocol. The main group (33 men - group II), against the background of standard therapy, received a course of ESWT, followed by a comparative assessment of clinical results regarding to the group of patients (30 men - group I) who received only standard therapy after the course, and after 3 and 6 months after treatment. RESULTS: Results: According to the results of transrectal ultrasonography in Doppler mode, a marked decrease in volumetric blood fl ow in the prostate gland of patients was observed. The use of ESWT against the background of standard treatment contributed to a longer and more stable clinical ef f ect, with a signif i cant improvement in hemodynamic parameters in the prostate unlike the results in the group of patients receiving only standard therapy. CONCLUSION: Conclusions: Signif i cant disorders of prostate hemodynamics were found in patients with NCPPS. Use on the background of standard treatment of ESWT in these patients is pathogenetically justif i ed with a lasting and stable clinical ef f ect.


Assuntos
Dor Crônica , Tratamento por Ondas de Choque Extracorpóreas , Prostatite , Animais , Doença Crônica , Dor Crônica/terapia , Humanos , Masculino , Camundongos , Dor Pélvica/terapia , Prostatite/terapia
6.
Am J Case Rep ; 22: e932869, 2021 Sep 03.
Artigo em Inglês | MEDLINE | ID: mdl-34475372

RESUMO

BACKGROUND Xanthogranulomatous prostatitis is rare, with no more than 10 to 15 cases reported to date. The presentation typically includes lower urinary tract or lower urinary tract infection symptoms. The present case report describes a 65-year-old man diagnosed with xanthogranulomatous prostatitis after a prolonged course of atypical symptoms. Symptom remission was achieved with low-dose Cymbalta and 6 weeks of ciprofloxacin. CASE REPORT A 65-year-old man had a 1-year history of pelvic floor disorder, including treatment-resistant tenesmus and rectal and perineal pain. The patient eventually developed a reduced urinary steam with urinary retention. On digital rectal examination, his prostate was non-tender and had significant firmness on the left side. Magnetic resonance imaging of the prostate with and without contrast showed a Prostate Imaging-Reporting and Data Stem 5 lesion involving the left peripheral zone of the prostate with diffuse enhancement and low signal throughout the gland. Suspicious adjacent lymphadenopathy also was present. The patient's prostate-specific antigen level was within the normal range at 2.4 ng/mL. All 13 left prostatic biopsy specimens showed acute and chronic inflammatory changes with prominent xanthogranulomatous features and without evidence of necrosis. All of the patient's symptoms, including pain, resolved after he started taking Cymbalta and completed a 6-week course of ciprofloxacin. CONCLUSIONS The present case report describes an atypical presentation of xanthogranulomatous prostatitis, which started with symptoms of pelvic floor disorder that preceded urinary symptoms by at least 1 year. The patient's symptoms improved after he started taking Cymbalta and completed a 6-week course of ciprofloxacin, 500 mg twice daily, and without concurrent treatment with an alpha blocker, corticosteroids, or pelvic floor therapy.


Assuntos
Prostatite , Infecções Urinárias , Idoso , Humanos , Imageamento por Ressonância Magnética , Masculino , Prostatite/diagnóstico , Prostatite/tratamento farmacológico , Doenças Raras
7.
Int J Mol Sci ; 22(15)2021 Jul 23.
Artigo em Inglês | MEDLINE | ID: mdl-34360620

RESUMO

BACKGROUND: Chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) is a frequent disease affecting men of every age and accounting for a great number of consultations at urology departments. Previous studies suggested a negative impact of CP/CPPS on fertility. As increasing attention has been attributed to additional aspects, such as sperm DNA integrity and sperm protein alterations, besides the WHO standard semen analysis when assessing male fertility, in this prospective study, we aimed to further characterize the fertility status in CP/CPPS patients with a focus on these parameters. METHODS: Sperm DNA fragmentation measured by sperm chromatin structure assay (SCSA) and protamine 1 to protamine 2 mRNA ratio assessed by RT-qPCR were analyzed along with conventional ejaculate parameters and inflammatory markers in 41 CP/CPPS patients and 22 healthy volunteers. RESULTS: We found significant differences between the groups concerning multiple conventional ejaculate parameters. A significant increase in sperm DNA fragmentation was shown in CP/CPPS patients with association to other sperm parameters. The majority of CP/CPPS patients exhibited protamine mRNA ratios out of the range of regular fertility. CONCLUSIONS: This is a pioneering study with a strong practical orientation revealing that CP/CPPS leads to increased sperm DNA damage and changes in sperm protamine levels, emphasizing an unfavorable impact of CP/CPPS on fertility.


Assuntos
Dor Crônica/metabolismo , Dor Pélvica/metabolismo , Prostatite/metabolismo , Protaminas/metabolismo , Espermatozoides/metabolismo , Adulto , Estudos de Casos e Controles , Fragmentação do DNA , Humanos , Masculino , Pessoa de Meia-Idade , Análise do Sêmen , Adulto Jovem
8.
Artigo em Russo | MEDLINE | ID: mdl-34380300

RESUMO

Taking into account the complex etiology and pathogenesis of chronic prostatitis, a large number of complications including the reproductive function impairment, the developing new effective methods of treating this pathology remains highly relevant. OBJECTIVE: Scientific substantiation of combined electric vacuum exposure in patients with chronic bacterial prostatitis (CBP). MATERIAL AND METHODS: The 90 patients with CBP aged 27-55 years were examined and were divided into 3 equal groups by the method of simple randomization. Patients of the main group received vacuum interference therapy procedures, the comparison group received interference therapy without vacuum exposure, and the control group received only standard drug therapy that was also prescribed in the first two groups. The effectiveness of therapy was assessed before, immediately after and 6 months after using the NIH-CPS, IPSS, QOL scales, trans-rectal ultrasound examination of the prostate gland, bacteriological examination and microscopy of a native preparation of prostate secretion and uroflowmetry. RESULTS: An improvement in the clinical symptoms of CBP was found largely in the groups receiving physiotherapy. In the main group there was a more significant volume decrease in the inflammatory-altered prostate gland (by 31.5%), in the comparison group the volume of the prostate gland decreased by 14%, and in the control group - by 9.6% that indicates the most pronounced anti-inflammatory effect of electro-vacuum actions. In the main group, there was also a more pronounced positive dynamics of dysuric disorders' indicators and maximum urination rate compared to the comparison and control groups. CONCLUSION: A higher clinical efficacy of vacuum interference therapy in patients with CBP (93.3%) has been proven compared with interference therapy (80.0%) and standard therapy (66.6%). The data obtained confirm the advantages and usage prospects of the combined physiotherapeutic effects.


Assuntos
Terapia por Estimulação Elétrica , Prostatite , Adulto , Doença Crônica , Humanos , Masculino , Pessoa de Meia-Idade , Prostatite/terapia , Qualidade de Vida , Vácuo
9.
Theriogenology ; 173: 202-210, 2021 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-34399384

RESUMO

Most old, intact male dogs usually have prostate disorders, especially benign prostatic hypertrophy and prostatitis with or without abscesses, and concurrent cystitis. The successful treatment of dogs with prostatitis concurrent with cystitis has relied on choosing an appropriate antimicrobial drug based on a bacterial culture and drug sensitivity testing. The objective of the study was to compare the prevalence of bacterial species and results of drug susceptibility testing of bacteria that were isolated from the prostatic fluids and urine samples that were collected from dogs with both prostatitis and cystitis. One hundred and sixty intact male dogs, who presented with both diseases, were recruited for the study. The disease diagnoses were based on clinical history notes, physical examinations, abdominal ultrasonography, prostatic fluid cytology, urinalysis and bacterial cultures from both prostatic fluid and urine samples. The bacterial culture results demonstrated that the major species that were detected in either the prostatic fluid or urine samples were Staphylococcus spp., Escherichia coli, Pseudomonas spp., Streptococcus spp., Proteus mirabilis and Klebsiella pneumoniae. Staphylococcus spp. (26.5 %, 43/162) and Escherichia coli (26.1 %, 12/46) were the most prevalent species from the prostatic fluid and urine samples, respectively. Statistical tests revealed that there were no significantly different prevalence levels among the isolated bacteria between the prostatic fluid and urine samples. Imipenem and gentamicin were the most potent antimicrobial drugs tested against the bacterial isolates in the present study. However, the administration of imipenem to treat prostatitis and cystitis in dogs was of concern. Interestingly, there were no significant differences in the antimicrobial drug susceptibility trends between the prostatic fluid and urine samples. Based on these results, a urine sample might be considered as an optional sample for bacterial cultures and antimicrobial drug susceptibility testing when it is not possible to collect a prostatic fluid sample.


Assuntos
Anti-Infecciosos , Cistite , Doenças do Cão , Mycobacterium tuberculosis , Prostatite , Animais , Antibacterianos/farmacologia , Antibacterianos/uso terapêutico , Cistite/tratamento farmacológico , Cistite/veterinária , Doenças do Cão/tratamento farmacológico , Cães , Masculino , Testes de Sensibilidade Microbiana/veterinária , Prostatite/tratamento farmacológico , Prostatite/veterinária
10.
Andrologia ; 53(10): e14206, 2021 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-34365673

RESUMO

In the past two decades, thousands of documents in the field of prostatitis have been published. This bibliometric analysis aimed to assess the characteristics, hotspots and frontiers trend of global scientific output on prostatitis. With the trend of moderate growth, altogether 2,423 papers were reviewed. The leading role of the United States in global prostatitis research was obvious, while China had developed rapidly in recent years. Queen's University and JOURNAL OF UROLOGY were the most prolific affiliation and journal respectively. Nickel, J. C made the greatest contribution to the field of prostatitis. Five hotspots have been confirmed: (a) male infertility associated with prostatitis and the molecular mechanisms; (b) diagnosis and treatment of prostatitis; (c) inflammation, pain and bladder irritation symptoms; (d) relationship between chronic prostatitis/chronic pelvic pain syndrome, benign prostatic hyperplasia and prostate cancer; (e) epidemiology, complications of prostatitis and improvement of acupuncture. This bibliometric analysis reveals that the international cooperation was becoming more and more close. Hotspot analysis shows that the molecular mechanism of prostatitis will be a hotspot in the future, mainly focussing on inflammatory immunity and oxidative stress.


Assuntos
Terapia por Acupuntura , Hiperplasia Prostática , Prostatite , Bibliometria , China/epidemiologia , Humanos , Masculino , Hiperplasia Prostática/epidemiologia , Prostatite/epidemiologia , Prostatite/terapia , Estados Unidos
11.
Zhongguo Zhen Jiu ; 41(8): 915-8, 2021 Aug 12.
Artigo em Chinês | MEDLINE | ID: mdl-34369704

RESUMO

To summarize professor QIU Xian-ling's clinical experience of acupuncture for treating chronic prostatitis. Professor QIU Xian-ling believes that the causes of chronic prostatitis are complex and diverse, and the main pathogenesis is kidney deficiency with excess. Professor QIU follows the traditional principles of syndrome differentiation and meridian differentiation, and adopts the combination of replenishing and reducing treatment and regulating the spirit and calming the mind. Guanyuan (CV 4), Huiyin (CV 1), Ciliao (BL 32) and Zhibian (BL 54) are the main acupoints that must be selected for treatment. During clinical treatment, according to the selected acupoints or the specific condition, special acupuncture methods such as deep needling with elongated needle method, lifting acupuncture method, three-in-one-retraction method, penetrating needling method and acupuncture combined with pressing method are used to achieve the purpose of comprehensive improvement of the local and overall state.


Assuntos
Terapia por Acupuntura , Acupuntura , Meridianos , Prostatite , Pontos de Acupuntura , Humanos , Masculino , Prostatite/terapia
12.
Urologiia ; (3): 70-74, 2021 Jun.
Artigo em Russo | MEDLINE | ID: mdl-34251104

RESUMO

INTRODUCTION: Benign prostatic hyperplasia (BPH), and chronic prostatitis (CP) are considered to be among the most common causes of lower urinary tract symptoms (LUTS) in men. The combination of BPH with CP raises many questions when choosing the right treatment strategy. For a long time, bioregulators isolated from the prostate gland of cattle have been successfully used in the treatment of CP. OBJECTIVE: to evaluate the effectiveness of bioregulatory peptides, in particular vitaprost, in the treatment of men with benign prostatic hyperplasia and chronic prostatitis. MATERIALS AND METHODS: The study included 60 patients with BPH and CP, who were divided into two groups of 30 people. In the comparison group (CG), complex therapy with drugs from the group of alpha-blockers and fluoroquinolones was performed. In the main group (MG), a similar complex therapy was performed in combination with vitaprost tablets. The effectiveness of the treatment was evaluated after two weeks (visit 2) and after 4 weeks (visit 3). RESULTS: In the MG, a more effective reduction in the severity of LUTs and manifestations of the inflammatory process was noted than in the HS. After 2 weeks of therapy in OG, the average score on the IPSS, QOL and NICH-CPSI questionnaires was lower by 2.4 points, 1.2 points and 2.5 points, respectively, the number of white blood cells in the prostate secret was on average 1.5 times less, and Qmax was higher by 1.4 ml/sec. The revealed differences were statistically significant (p<0.05). This trend continued after 4 weeks of therapy. CONCLUSION: Thus, the use of bioregulatory peptides, in particular the drug vitaprost, in patients with BPH and CP helps to reduce the severity of LUTs and pain in a shorter time, has a positive effect on the dynamics of the inflammatory process, which leads to an improvement in the quality of life of patients in this category.


Assuntos
Sintomas do Trato Urinário Inferior , Hiperplasia Prostática , Prostatite , Animais , Bovinos , Humanos , Sintomas do Trato Urinário Inferior/tratamento farmacológico , Sintomas do Trato Urinário Inferior/etiologia , Masculino , Peptídeos/uso terapêutico , Hiperplasia Prostática/complicações , Hiperplasia Prostática/tratamento farmacológico , Prostatite/tratamento farmacológico , Qualidade de Vida
13.
Health Qual Life Outcomes ; 19(1): 159, 2021 May 31.
Artigo em Inglês | MEDLINE | ID: mdl-34059073

RESUMO

BACKGROUND: The National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) was developed to accurately assess the pain, urinary symptoms, and quality of life related to chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). This study aimed to evaluate the cross-cultural adaptations of the NIH-CPSI. METHOD: PubMed, Embase, CINAHL, and SciELO databases were searched from their established year to September 2020. Cross-cultural adaptations and the quality control of measurement properties of adaptations were conducted by two reviewers independently according to the Guidelines for the Process of Cross-Cultural Adaptation of Self-Report Measures and the Quality Criteria for Psychometric Properties of Health Status Questionnaire. RESULTS: Area total of 21 papers with 16 adaptations, and six studies of the original version of the NIH-CPSI were enrolled in the systematic review. Back translation was the weakest process for the quality assessment of the cross-cultural adaptations of the NIH-CPSI. Internal consistency was analyzed for most of the adaptations, but none of them met the standard. Only 11 adaptations reported test reliability, then only the Arabic-Egyptian, Chinese-Mainland, Danish, Italian, Persian, and Turkish adaptations met the criterion. Most adaptations reported the interpretability, but only the Danish adaptation reported the agreement. The other measurement properties, including responsiveness, and floor as well as ceiling effects were not reported in any of the adaptations. CONCLUSIONS: The overall quality of the NIH-CPSI cross-cultural adaptations was not organized as expected. Only the Portuguese-Brazilian, Italian, and Spanish adaptations reached over half the process for the cross-cultural adaptation. Only the Turkish adaptations finished half of the measurement properties of cross-cultural adaptations.


Assuntos
Dor Crônica/psicologia , Comparação Transcultural , Prostatite/fisiopatologia , Prostatite/psicologia , Qualidade de Vida/psicologia , Inquéritos e Questionários/normas , Avaliação de Sintomas/normas , Adulto , Idoso , Idoso de 80 Anos ou mais , Dor Crônica/fisiopatologia , Nível de Saúde , Humanos , Masculino , Pessoa de Meia-Idade , National Institutes of Health (U.S.) , Psicometria , Reprodutibilidade dos Testes , Autorrelato/estatística & dados numéricos , Inquéritos e Questionários/estatística & dados numéricos , Traduções , Estados Unidos
14.
Aktuelle Urol ; 52(4): 338-344, 2021 Aug.
Artigo em Alemão | MEDLINE | ID: mdl-34102684

RESUMO

The use of modern molecular technologies in the last decade has given us new insights into the complex interactions of the human microbiome in health and in the pathogenesis of diseases. Among other things, the sterility concept of the urinary tract has been discarded and the goal is now to identify the different microbial signatures associated with various diseases. Dysbalances of the microbiome are increasingly suspected of causing negative effects on various malignant and benign diseases. Recently, such associations have also been shown for prostate carcinoma, renal cell carcinoma and urinary bladder carcinoma. This may lead to the discovery of new potential biomarkers for the diagnosis and as a therapeutic target of the diseases mentioned. For the diagnosis of some benign diseases such as interstitial cystitis, urge incontinence and chronic prostatitis or chronic pelvic pain syndrome, microbial involvement was previously considered an exclusion criterion. However, current studies show that the individual patient's microbiome can have an influence on the development and severity of the respective disease.


Assuntos
Cistite Intersticial , Microbiota , Prostatite , Humanos , Masculino , Dor Pélvica
16.
Urologiia ; (2): 32-39, 2021 May.
Artigo em Russo | MEDLINE | ID: mdl-33960154

RESUMO

INTRODUCTION: The problem of chronic prostatitis is still to be resolved. AIM: to compare the frequency of the main symptoms (pain, dysuria, sexual dysfunction) in patients with chronic bacterial and abacterial prostatitis, as well as prostate tuberculosis (PTB); to determine the prevalence of latent infectious prostatitis in patients with chronic abacterial prostatitis (CAP). MATERIALS AND METHODS: A total 73 men who were followed with a diagnosis of chronic prostatitis for at least two years and had a history of at least three exacerbations per year were included in the study. A microbiological study of expressed prostate secretions (EPS) was carried out using both routine and molecular genetic methods. RESULTS: Chronic bacterial prostatitis (CBP) was diagnosed in 27 patients (37.0%). 36.7% of pathogens were resistant to antibiotics. In 46 patients (63%) no microflora was not isolated at the first examination. In some patients with CBP, prostate tuberculosis (PTB) was diagnosed. Thus, in the total cohort of patients, only 17 (23.3%) had isolated CBP, and other 10 (13.7%) had CBP in combination with PTB. All patients with CAP received longidaza rectal suppositories for diagnostic purposes. In 23 men (50.0% of patients with CAP), uropathogens were isolated from EPS after administration of longidaza, and 56.9% of them were resistant to antibacterial drugs. Five patients from this group also had PTB, and 18 (24.6%) had CBP, which was not diagnosed by standard methods. There were no significant differences in the frequency of pain and urinary disorders. However, sexual dysfunction more often developed in patients with CAP and PTB (p<0.05); hemospermia, on the other hand, was not typical for patients with CAP, occurred in few cases with CBP and latent CAP, but was present in two-thirds of patients with PTB. CONCLUSION: As a mask of CAP, both latent CPB and PTB can present. Although CBP, CAP, latent CBP and PTB have a number of significant differences in the clinical manifestations, no pathognomonic symptoms have been identified for these subgroups of chronic prostatitis. Considering that half of patients with CAP actually have latent CBP, it is necessary to use rectal suppositories of the drug longidaza for diagnostic purposes with repeated analysis of expressed prostate secretions. To identify pathogens, molecular genetic diagnostics should be used along with routine methods. PTB can manifest as chronic bacterial or abacterial prostatitis. It is necessary to carefully study the patient's history, epidemic history, and, if indicated, to perform an appropriate examination to exclude PTB.


Assuntos
Prostatite , Tuberculose dos Genitais Masculinos , Antibacterianos/uso terapêutico , Doença Crônica , Humanos , Masculino , Prostatite/diagnóstico , Prostatite/tratamento farmacológico , Prostatite/epidemiologia , Tuberculose dos Genitais Masculinos/tratamento farmacológico
17.
Sichuan Da Xue Xue Bao Yi Xue Ban ; 52(3): 477-484, 2021 May.
Artigo em Chinês | MEDLINE | ID: mdl-34018368

RESUMO

Objective: To establish an experimental prostatitis animal model in Sprague-Dawley (SD) rats through induction by treatment of estrogen and androgen at different concentrations. Methods: Fifty-three male SD rats aged 3 to 4 months were used in the study, and the castration model of male rats was established by excision of bilateral testes. The rats were randomly assigned to a blank group, a castration group and treatment groups receiving estrogen and androgen at different concentrations after castration, with 4 rats in each group. Dihydrotestosterone (DHT) and estradiol (E) were administered daily by subcutaneous injection to the treatment groups. All the rats were sacrificed by way of cervical dislocation after 1 month and the serum DHT and E concentrations of the rats in each group were assessed with ELISA. Prostate specimens were collected and the relative weight of the prostate of each group of rats was calculated. After HE staining of the prostate tissue, we observed with optic microscope structural changes in the prostate tissue and the state of prostatic inflammation in each group. Immunohistochemical examination was done to assess the expression of three inflammatory factors, transforming growth factor-ß1 (TGF-ß1), interleukin (IL)-6 and IL-8, in rat prostate tissues. Results: The results of HE staining of rat prostate tissue showed that, compared with the blank group and castration group, the degree of inflammation increased significantly in the E0.05+DHT 0.5 mg/kg group and DHT0.15+E0.15 mg/kg group ( P<0.05). However, once the concentration of DHT exceeded 0.5 mg/kg, the degree of inflammation did not further aggravate. The results of immunohistochemical staining showed that when the concentration of exogenous E was constant, the expression of TGF-ß1 and IL-8 increased significantly in the E0.05+DHT 0.15 mg/kg group, E0.05+DHT 0.5 mg/kg group and E0.05+DHT 1.5 mg/kg group compared with that of the blank group ( P<0.05). In the E0.05+DHT 0.15 mg/kg group and E0.05+DHT 0.5 mg/kg group, the expression of TGF-ß1 and IL-8 increased significantly compared with that of the castration group ( P<0.05). Once the concentration of DHT reached 0.5 mg/kg, further increase in the concentration of DHT did not lead to any significant changes in the expression of TGF-ß1 or IL-8. In addition, when the concentration of exogenous DHT remained unchanged, the expressions of TGF-ß1, IL-6, and IL-8 increased significantly in the DHT0.15+E 0.05 mg/kg group and DHT0.15+E 0.5 mg/kg group, compared with that of the blank group and castration group ( P<0.05). Conclusion: Castration combined with treatment of different concentrations of estrogen and androgen could successfully induce the prostatitis model in SD rats.


Assuntos
Androgênios , Prostatite , Animais , Estrogênios , Humanos , Masculino , Ratos , Ratos Sprague-Dawley , Testosterona
18.
J Cell Mol Med ; 25(12): 5753-5768, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-33982874

RESUMO

Qianliexin capsule (QLX) is a standardized traditional Chinese herbal preparation that has long been used to treat chronic non-bacterial prostatitis (CNP) and benign prostatic hyperplasia (BPH). This study investigated the anti-inflammatory activity of QLX in improving lower urinary tract symptoms (LUTS) associated with CNP and BPH. Rat models of CNP and BPH were induced by oestradiol or testosterone (hormonal imbalance) or chemical inflammation (carrageenan). QLX significantly relieved LUTS in CNP and BPH rat model by reducing prostate enlargement, epithelial thickness, pain response time, urine volume and bleeding time, and by improving prostatic blood flow. The expression of the pro-inflammatory cytokines interleukin (IL)-1ß and tumour necrosis factor (TNF)-α, the pro-inflammatory transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and inflammasome components (NLRP3, caspase-1 and ASC) in CNP and BPH tissues was reduced by QLX addition. QLX treatment was followed by reduced cellular malondialdehyde and increased superoxide dismutase, catalase and glutathione peroxidase activity, consistent with antioxidant activity. Increases in Beclin-1 expression and the LC3II/I ratio following QLX treatment indicated that autophagy had been induced. QLX relieved LUTS in CNP and BPH rat models by inhibiting inflammation. The underlying mechanisms included inhibition of inflammasome activation, NF-κB activation, oxidant stress and autophagy.


Assuntos
Anti-Inflamatórios/farmacologia , Medicamentos de Ervas Chinesas/química , Inflamassomos/efeitos dos fármacos , Inflamação/tratamento farmacológico , Extratos Vegetais/farmacologia , Hiperplasia Prostática/tratamento farmacológico , Prostatite/tratamento farmacológico , Animais , Antioxidantes/farmacologia , Cápsulas/administração & dosagem , Inflamação/imunologia , Inflamação/metabolismo , Inflamação/patologia , Masculino , Hiperplasia Prostática/imunologia , Hiperplasia Prostática/metabolismo , Hiperplasia Prostática/patologia , Prostatite/imunologia , Prostatite/metabolismo , Prostatite/patologia , Ratos , Ratos Sprague-Dawley , Transdução de Sinais
19.
20.
Andrologia ; 53(8): e14113, 2021 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-33979463

RESUMO

The present study aimed to investigate the mechanism of penile damages in experimental autoimmune prostatitis (EAP) rat models to reveal the potential pathological mechanism of the relationship between CP and penile damages. Sprague-Dawley (SD) rats were administered with different concentrations of prostate tissue homogenate supernatant (PTHS) by multipoint subcutaneous injection to establish EAP models. IHC staining was done to assess the expression of inflammatory cytokines in prostate tissues and the corpus cavernosum of penis. Masson and Tunel staining was conducted to observe the fibrosis and apoptosis in the corpus cavernosum. Finally, the functional changes of corpus cavernosum were assessed by WB and IHC staining. The results revealed that EAP rats with different prostatitis severity were successfully established by PTHS. The expression of IL-1ß, IL-6 and TNF-α in prostate tissues increased with the concentration of PTHS. The results of Masson and Tunel staining indicated fibrosis and apoptosis gradually aggravated in corpus cavernosum among different subgroups. The function of cavernosum impaired by prostatitis from WB and IHC results and positively with the severity. In conclusion, there existed the infiltration of inflammatory factors and impaired function in the corpus cavernosum of EAP rats' penis and positively correlated with the severity of prostatitis.


Assuntos
Prostatite , Animais , Doença Crônica , Modelos Animais de Doenças , Humanos , Masculino , Pênis , Ratos , Ratos Sprague-Dawley
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