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1.
Przegl Lek ; 70(8): 687-9, 2013.
Artigo em Polonês | MEDLINE | ID: mdl-24466722

RESUMO

UNLABELLED: We described two cases of poisoning with amygdalin. Clinical signs presented by two females were mild and lasted up to 5 hours. CONCLUSIONS: The usage of amygdalin may be connected with serious side effects. The cyanide and prussic acid which are deliberated in digestive system are responsible for toxicity in such cases. The rarity of poisoning with amygdalin as well as high cost of analysis are responsible for the reason that most labs are not prepare for such procedure.


Assuntos
Amigdalina/toxicidade , Antineoplásicos/envenenamento , Fitoterapia/efeitos adversos , Preparações de Plantas/envenenamento , Prunus/envenenamento , Sementes/envenenamento , Idoso , Amigdalina/química , Feminino , Humanos , Pessoa de Meia-Idade
2.
Emerg Med J ; 28(9): 804-5, 2011 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-21856998

RESUMO

Clinical experience with hydroxocobalamin in acute cyanide poisoning via ingestion remains limited. This case concerns a 35-year-old mentally ill woman who consumed more than 20 apricot kernels. Published literature suggests each kernel would have contained cyanide concentrations ranging from 0.122 to 4.09 mg/g (average 2.92 mg/g). On arrival, the woman appeared asymptomatic with a raised pulse rate and slight metabolic acidosis. Forty minutes after admission (approximately 70 min postingestion), the patient experienced headache, nausea and dyspnoea, and was hypotensive, hypoxic and tachypnoeic. Following treatment with amyl nitrite and sodium thiosulphate, her methaemoglobin level was 10%. This prompted the administration of oxygen, which evoked a slight improvement in her vital signs. Hydroxocobalamin was then administered. After 24 h, she was completely asymptomatic with normalised blood pressure and other haemodynamic parameters. This case reinforces the safety and effectiveness of hydroxocobalamin in acute cyanide poisoning by ingestion.


Assuntos
Hematínicos/uso terapêutico , Cianeto de Hidrogênio/envenenamento , Hidroxocobalamina/uso terapêutico , Prunus/envenenamento , Doença Aguda , Adulto , Feminino , Humanos , Envenenamento/tratamento farmacológico , Envenenamento/etiologia , Sementes/envenenamento , Resultado do Tratamento
3.
BMJ Case Rep ; 20112011 May 24.
Artigo em Inglês | MEDLINE | ID: mdl-22694886

RESUMO

Clinical experience with hydroxocobalamin in acute cyanide poisoning via ingestion remains limited. This case concerns a 35-year-old mentally ill woman who consumed more than 20 apricot kernels. Published literature suggests each kernel would have contained cyanide concentrations ranging from 0.122 to 4.09 mg/g (average 2.92 mg/g). On arrival, the woman appeared asymptomatic with a raised pulse rate and slight metabolic acidosis. Forty minutes after admission (approximately 70 min postingestion), the patient experienced headache, nausea and dyspnoea, and was hypotensive, hypoxic and tachypnoeic. Following treatment with amyl nitrite and sodium thiosulphate, her methaemoglobin level was 10%. This prompted the administration of oxygen, which evoked a slight improvement in her vital signs. Hydroxocobalamin was then administered. After 24 h, she was completely asymptomatic with normalised blood pressure and other haemodynamic parameters. This case reinforces the safety and effectiveness of hydroxocobalamin in acute cyanide poisoning by ingestion.


Assuntos
Antídotos/uso terapêutico , Cianetos/envenenamento , Hidroxocobalamina/uso terapêutico , Prunus/envenenamento , Sementes/envenenamento , Adulto , Feminino , Humanos
5.
Vet Anaesth Analg ; 36(3): 255-60, 2009 May.
Artigo em Inglês | MEDLINE | ID: mdl-19397777

RESUMO

OBSERVATIONS: A case of a pony with severe cyanide intoxication as a result of cherry ingestion is presented. General anaesthesia was performed for colic surgery. Severe metabolic lactate acidosis in combination with a high arterial oxygen partial pressure and clinically good peripheral perfusion parameters were the remarkable signs during anaesthesia. Severe hypothermia was obvious during recovery. Ten hours post-surgery the pony was euthanized as a result of neurological signs. The diagnosis of cyanide intoxication was made post-mortem. CONCLUSION: Cherry ingestion can lead to lethal cyanide intoxication in horses indicated by severe nonhypoxic lactic acidosis during anaesthesia.


Assuntos
Anestesia/veterinária , Anestésicos/efeitos adversos , Cianetos/envenenamento , Doenças dos Cavalos/induzido quimicamente , Complicações Pós-Operatórias/veterinária , Prunus/envenenamento , Anestesia/efeitos adversos , Animais , Evolução Fatal , Doenças Transmitidas por Alimentos , Cavalos , Masculino , Complicações Pós-Operatórias/induzido quimicamente
7.
J Vet Diagn Invest ; 16(6): 593-9, 2004 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-15586581

RESUMO

Prunus serotina Ehrh. (black cherry) intoxication was diagnosed on postmortem examination of a goat. The clinical signs were weakness, depression, seizure-like activity, and lateral recumbency. Natural cases of black cherry intoxication have not been reported in goats in the United States. In the absence of a history of access to black cherry or the ability to detect cyanide or cyanogenic glycosides in blood or tissues, black cherry intoxication may be diagnosed in ruminants by the identification of black cherry leaves in rumen contents. Three distinctive features facilitate identification of black cherry leaves or leaf fragments: 1) a pair of small glands that protrude from the sides of the petiole just below the base of the blade, 2) incurved, gland-tipped (callous) teeth along the margins of the leaf, and 3) a band of hairs to each side of the lower half of the midvein on the surface of the leaf. Shape of the marginal teeth, presence or absence of glands at the tips of these teeth, the morphology of these glands, and presence or absence of petiolar glands and their morphology may allow identification and differentiation of small fragments of leaves from the 6 most important cyanogenic Prunus spp. in eastern North America: black cherry, Carolina laurel cherry, peach, English laurel cherry, choke cherry, and fire cherry.


Assuntos
Doenças das Cabras/diagnóstico , Folhas de Planta/envenenamento , Intoxicação por Plantas/veterinária , Plantas Tóxicas , Prunus/envenenamento , Animais , Doenças das Cabras/mortalidade , Cabras , Masculino , Intoxicação por Plantas/diagnóstico , Intoxicação por Plantas/mortalidade , Rúmen
8.
Tree Physiol ; 21(10): 633-43, 2001 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-11446992

RESUMO

We analyzed several genes that were strongly expressed in response to dehydration of almond (Prunus amygdalus (L.) Batsch) as a means of identifying and determining the genetic basis of mechanisms involved in drought tolerance. The advantages of using almond as a model system for studying dehydration tolerance in woody species include its small diploid genome and its adaptation to drought. We used the differential expression technique cDNA-AFLP (amplified restriction fragment polymorphism derived technique for RNA fingerprinting) to identify transcripts that accumulated in mature embryos and in in-vitro-cultured plantlets subjected to desiccation or abscisic acid (ABA) treatment. The reverse northern approach was used to differentiate between true differential bands and false positives. Some of the predicted polypeptides exhibited similarity to published protein sequences, including a transporter of nitrogenous compounds, a 1-acyl-sn-glycerol-3-phosphate acyl transferase, a low molecular weight heat shock protein, a cysteine proteinase and a constitutively expressed proline-rich protein. We also compared the levels of expression of the identified genes in leaves of young trees of eight almond cultivars differing in drought tolerance.


Assuntos
Prunus/genética , Árvores/genética , 1-Acilglicerol-3-Fosfato O-Aciltransferase , Aciltransferases/genética , Sequência de Aminoácidos , Arabidopsis/genética , Brassica napus/genética , Cisteína Endopeptidases/genética , Impressões Digitais de DNA , DNA Complementar/genética , Dessecação , Perfilação da Expressão Gênica , Proteínas de Choque Térmico/genética , Lycopersicon esculentum/genética , Dados de Sequência Molecular , Folhas de Planta/genética , Polimorfismo de Fragmento de Restrição , Prolina/metabolismo , Prunus/fisiologia , Prunus/envenenamento , Reação em Cadeia da Polimerase Via Transcriptase Reversa , Homologia de Sequência de Aminoácidos , Árvores/fisiologia , Água/fisiologia , Zea mays/genética
9.
Vet. Méx ; 23(2): 131-3, abr.-jun. 1992. tab
Artigo em Espanhol | LILACS | ID: lil-118359

RESUMO

El aguacatillo (Prunus brachybotrya) es una planta que perteneca al género de los Prunus y familia de las rosáceas. Puede contener ácido cianhídrico en las hojas, tallo y fruto; si es consumida por el ganado es letal. Se desarrolla y fructifica en laqs faldas de los volcanes Popocatepetl e Ixtaccihuatl. En el presente tranajo se analizó in vitro el contenido de cianuro del aguacatillo en hojas, tallo y fruto por la técnica de Steyn modificada. El muestreo se realizó de marzo a julio de 1989, con intervalos de 15 días entre una muestra y otra. En las primeras tres muestras, la concentración de cianuro aumentó en laqs tres partes de la planta (hoja, fruto y tallo). En la hoja, a partir de mayo, la concentración de cianuro empezó a disminuir. En julio, la concentración de cianuro en el fruto bajó a cero; en el tallo, bajó ligeramente. Las concentraciones fueron de 1.7 porciento en la hoja y fruto; en el último, declinó hasta cero al 5to mes durante la maduración, En el tallo tierno, la concentración due fe 0.25 porciento; durante el estudio, se mantuvo en este nivel. El aguacatillo se considera más peligroso en los meses de abril a mayo, ya que durante este periodo la concentración de cianuro es mayor. Así, la intoxicación se intensifica más que en los otros meses, aunque està presente todo el año.


Assuntos
Cianetos/análise , Plantas Tóxicas/análise , Prunus domestica/envenenamento , Prunus mahaleb/envenenamento , Prunus padus/envenenamento , Prunus spinosa/envenenamento , Prunus/envenenamento , Árvores
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