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2.
Hematol Oncol ; 37(4): 483-486, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31408541

RESUMO

In absence of red blood cells disease or immune defect, parvovirus B19 (PVB-19) is usually considered as a benign condition. Here, we report the case of a 10-year-old boy, previously healthy, presenting with a PVB-19 infection revealed by a bicytopenia and a voluminous axillary adenopathy. Pathophysiology examination showed reactional lymphoid population. Nine months later and in the absence of remission, a new biopsy of the same adenopathy revealed a Hodgkin lymphoma with area of T-cell rich aggressive large B-cell lymphoma. This case suggests PVB-19 as potential trigger of this malignant childhood hemopathy. Although no definitive conclusion can be drawn, our clinical case questions the role of PVB-19 in lymphomagenesis.


Assuntos
Eritema Infeccioso/complicações , Doença de Hodgkin/etiologia , Linfoma de Células B/etiologia , Neoplasias Primárias Múltiplas/etiologia , Viremia/complicações , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Linfócitos B/patologia , Medula Óssea/patologia , Medula Óssea/virologia , Criança , Eritema Infeccioso/sangue , Eritema Infeccioso/patologia , Eritema Infeccioso/virologia , Doença de Hodgkin/patologia , Humanos , Linfoma de Células B/patologia , Masculino , Neoplasias Primárias Múltiplas/patologia , Pancitopenia/etiologia , Pseudolinfoma/etiologia , Indução de Remissão , Rituximab/administração & dosagem , Linfócitos T/patologia , Sequenciamento Completo do Exoma
3.
Hematology ; 24(1): 544-551, 2019 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-31315540

RESUMO

Objective: Immunoglobulin D (IgD) levels are often elevated in patients with autoimmune diseases. However, the oncogenic activities of IgD and IgD receptor (IgDR) in diffuse large B-cell lymphoma (DLBCL) have not been reported in detail. Therefore, we aimed to investigate the expression of IgD and IgDR in patients with DLBCL. Methods: Membrane IgD (mIgD) and IgDR expression in tissue samples was analyzed using IHC, mIgD and IgDR expression on peripheral blood mononuclear cells (PBMCs) was analyzed by FCM, and secreted IgD (sIgD) level was analyzed by ELISA. Fisher's exact test and Spearman correlation analysis were used to evaluate the relationship between IgD, IgDR, and clinical parameters. Results: The pathological lymph nodes of 34 patients with DLBCL were studied, and mIgD and IgDR expression was found in 16 and 19 patients. mIgD and IgDR expression was upregulated in patients with DLBCL and mIgD expression was significantly associated with IgDR expression. Further correlation analysis showed that mIgD expression was correlated with serum ß2-MG level and Hans algorithm as germinal center B (GCB), whereas IgDR expression correlated with serum LDH level, IPI score and GCB. ELISA showed that sIgD level was significantly increased in DLBCL patients and it correlated with serum ß2-MG and LDH levels. FCM showed that mIgD and IgDR expression in PBMCs of patients with DLBCL was significantly higher than that in healthy controls. Conclusion: Our findings suggest that overexpression of IgD and IgDR is an abnormal activation state in DLBCL.


Assuntos
Regulação Neoplásica da Expressão Gênica , Imunoglobulina D/biossíntese , Leucócitos Mononucleares/química , Receptores Fc/biossíntese , Estudos de Casos e Controles , Linhagem Celular Tumoral , Membrana Celular/imunologia , Feminino , Humanos , Imunoglobulina D/análise , Imunoglobulina D/genética , L-Lactato Desidrogenase/sangue , Linfonodos/química , Linfonodos/patologia , Linfoma Difuso de Grandes Células B/sangue , Linfoma Difuso de Grandes Células B/patologia , Masculino , Pseudolinfoma/sangue , Pseudolinfoma/patologia , Receptores Fc/análise , Receptores Fc/genética , Regulação para Cima , Microglobulina beta-2/análise
4.
Int J Dermatol ; 58(11): 1270-1276, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31347153

RESUMO

BACKGROUND: Primary cutaneous lymphomas (PCLs) and pseudolymphomas presenting as single pink-red nodules/tumors are highly unspecific and include a wide differential diagnosis. OBJECTIVE: To describe the dermoscopic characteristics of PCL/pseudolymphoma. METHODS: In this retrospective, case-control study, we evaluated the dermoscopic features of patients with solitary PCL/pseudolymphoma tumors and compared them to a control group of non-lymphomatous, nonpigmented, solitary tumors (e.g., basal cell carcinoma, amelanotic melanoma, etc). RESULTS: We included 14 patients with PCL/pseudolymphomas and 35 controls. T-cell and B-cell lymphoma proportions were 28.6% (n = 4) and 71.4% (n = 10), respectively. Compared to controls, most lymphomas presented dermoscopically with orange color (71.4% vs. 14.2%, P < 0.001), follicular plugs (85% vs. 2.8%, P < 0.001), and as  organized lesions (85% vs. 31.4%, P = 0.001). Coexistence of orange color and follicular plugs had an odds ratio (OR) of 2.8 (P < 0.001), highly suggestive of PCL . The kappa index for independent observers was 0.66, 0.49, 0.43 for orange background, follicular plugs, and organized lesion, respectively. Histopathologic correlation was performed in six PCL cases and showed dense diffuse and perifollicular lymphocytic infiltrate in all cases and keratin plugs in five of six cases, possibly correlating with the orange color and the follicular plugs, respectively. CONCLUSION: Primary cutaneous lymphomas/pseudolymphomas present with characteristic dermoscopic findings irrespective of immunohistochemical subtype.


Assuntos
Linfoma de Células B/diagnóstico por imagem , Linfoma Cutâneo de Células T/diagnóstico , Pseudolinfoma/diagnóstico por imagem , Neoplasias Cutâneas/diagnóstico por imagem , Pele/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Biópsia , Carcinoma Basocelular/diagnóstico por imagem , Estudos de Casos e Controles , Dermoscopia , Diagnóstico Diferencial , Feminino , Humanos , Linfoma de Células B/patologia , Linfoma Cutâneo de Células T/patologia , Masculino , Melanoma Amelanótico/diagnóstico por imagem , Pessoa de Meia-Idade , Pseudolinfoma/patologia , Estudos Retrospectivos , Pele/diagnóstico por imagem , Neoplasias Cutâneas/patologia
5.
Surg Pathol Clin ; 12(3): 745-770, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31352986

RESUMO

Although about 90% of the world's population is infected by EBV only a small subset of the related infections result in neoplastic transformation. EBV is a versatile oncogenic agent involved in a multitude of hematopoietic, epithelial, and mesenchymal neoplasms, but the precise role of EBV in the pathogenesis of many of the associated lymphoid/histiocytic proliferations remains hypothetical or not completely understood. Additional studies and use of evolving technologies such as high-throughput next-generation sequencing may help address this knowledge gap and may lead to enhanced diagnostic assessment and the development of potential therapeutic interventions.


Assuntos
Infecções por Vírus Epstein-Barr/classificação , Transtornos Linfoproliferativos/classificação , Animais , Doença Crônica , Culicidae , Diagnóstico Diferencial , Humanos , Hidroa Vaciniforme/diagnóstico , Imunossupressores/efeitos adversos , Mononucleose Infecciosa/diagnóstico , Mordeduras e Picadas de Insetos/diagnóstico , Linfoma de Células B/classificação , Linfoma de Células B/virologia , Linfoma de Células T/classificação , Linfoma de Células T/virologia , Granulomatose Linfomatoide/diagnóstico , Transtornos Linfoproliferativos/virologia , Neoplasias de Plasmócitos/diagnóstico , Prognóstico , Pseudolinfoma/diagnóstico , Pseudolinfoma/virologia , Latência Viral/fisiologia
6.
Medicine (Baltimore) ; 98(30): e16491, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31348258

RESUMO

RATIONALE: Reactive lymphoid hyperplasia (RLH) of the liver is an uncommon benign lesion. It is usually difficult to differentiate from hepatocellular carcinoma (HCC), peripheral-type cholangiocellular carcinoma (CCC), combined HCC-CCC, and liver metastases. On account of its rarity and controversial issues, we report a case report and review the literature to discuss its clinical features, treatments, radiological, and immunohistochemical characteristics. PATIENT CONCERNS: A 54-year-old woman had a history of primary biliary cirrhosis and chronic cholecystitis. She complained of finding a lesion in the right liver during her last medical check-up by abdominal B type ultrasound. The Contrast-enhanced computed tomography revealed a circular and low-density lesion in the right posterior lobe of the liver, approximately 22.0 × 18.7 mm in size. On magnetic resonance imaging, the lesion showed low-signal intensity on T1-weighted images and high signal intensity on T2-weighted images. Laboratory test results were almost normal. DIAGNOSIS: After the postoperative pathological and immunohistochemical examination, the patient was finally diagnosed as having RLH. INTERVENTIONS: The patient received right posterior lobe hepatectomy and cholecystectomy. OUTCOMES: The patient was discharged 11 days after surgery. No evidence of recurrence was noted 1 year after the surgery. LESSONS: Although RLH of the liver is rare, it is necessary to be considered in a liver lesion, especially in female patients. This case report may advance the understanding of RLH of the liver and reduce the number of mistakenly diagnosed patients.


Assuntos
Hepatopatias/diagnóstico , Pseudolinfoma/diagnóstico , Colecistectomia , Colecistite/complicações , Feminino , Hepatectomia , Humanos , Cirrose Hepática Biliar/complicações , Hepatopatias/complicações , Hepatopatias/cirurgia , Pessoa de Meia-Idade , Pseudolinfoma/complicações , Pseudolinfoma/cirurgia
7.
Acta Dermatovenerol Croat ; 27(2): 116-120, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31351507

RESUMO

Pseudolymphoma is a benign, reversible, inflammatory, reactive, and polyclonal lymphocyte proliferation, which regresses spontaneously or heals after elimination of the causal factor. A female patient, aged 33, presented with a painful, erythematosus, radiant tumor formation on the skin in the temporal region. The patient had enlarged lymph nodes on the right side of the neck before the appearance of that tumor formation. The dermatoscopic finding was nonspecific. After the tumor biopsy was performed, the diagnosis of reactive lymphatic proliferation - pseudolymphoma or cutaneous lymphoma of B-cell immunophenotype - was established histologically. After we completely excised the skin change, the immunohistochemical finding indicated fluoride skin lymphocyte hyperplasia of B- and T-lymphocytes. The results of other findings were normal (serologic test for Borrelia burgdoferi, ultrasound of the cervical and supraclavicular lymph nodes, as well as ultrasound of the abdomen and axillary and inguinal regions). However, the etiology of the disease remains unknown. This case report confirms that the correlation between clinical presentation, dermatoscopic examination, histologic and immunohistochemical analysis, and the therapy response is crucial for diagnosis of pseudolymphoma and patient outcome.


Assuntos
Face , Pseudolinfoma/diagnóstico , Dermatopatias/diagnóstico , Adulto , Biópsia , Dermoscopia , Diagnóstico Diferencial , Feminino , Humanos , Pseudolinfoma/cirurgia , Dermatopatias/cirurgia
8.
J Cutan Pathol ; 46(10): 717-722, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31062372

RESUMO

BACKGROUND: In cases of herpes virus infection without typical histologic (and clinical) signs it is difficult to achieve the correct diagnosis by histology alone. Some of those cases are prone to be misdiagnosed as cutaneous lymphoma. METHODS: This retrospective study included five patients with herpes simplex virus (HSV)-associated pseudolymphoma. We investigated clinical, histomorphologic and immunophenotypic features of all patients. RESULTS: All biopsy specimens presented a superficial and deep perivascular lymphohistiocytic infiltrate with epidermotropism, atypia and admixed plasma cells to varying degrees. Four of five samples showed lining-up of lymphocytes in the junctional zone with predominance of CD8+ lymphocytes, in contrast to the dermal part (inverse CD8:CD4 ratio). Papillary edema was found in four of five cases. Clinically, patchy erythema located on the buttocks and adjacent areas was typical, sometimes with erosions and crusts. Medical history of recurrent blisters, pain or itching was additionally helpful. CONCLUSION: We point out subtle but consistent histomorphologic criteria, which were helpful to diagnose HSV-associated pseudolymphoma in context with the clinical presentation.


Assuntos
Linfócitos T CD4-Positivos , Linfócitos T CD8-Positivos , Herpes Simples , Pseudolinfoma , Simplexvirus/imunologia , Dermatopatias , Adolescente , Adulto , Linfócitos T CD4-Positivos/imunologia , Linfócitos T CD4-Positivos/patologia , Linfócitos T CD8-Positivos/imunologia , Linfócitos T CD8-Positivos/patologia , Criança , Pré-Escolar , Feminino , Herpes Simples/imunologia , Herpes Simples/patologia , Humanos , Masculino , Pessoa de Meia-Idade , Pseudolinfoma/imunologia , Pseudolinfoma/patologia , Estudos Retrospectivos , Dermatopatias/imunologia , Dermatopatias/patologia
9.
Turkiye Parazitol Derg ; 43(1): 50-52, 2019 Mar 28.
Artigo em Inglês | MEDLINE | ID: mdl-30938141

RESUMO

Pseudolymphoma, also known as Jessner's lymphocytic infiltration, is a benign but usually chronic, T-cell infiltrating disease with erythematous papules and plaques usually seen on the skin of the face, neck, and back. The use of leech therapy also known as hirudotherapy has increased in recent years. Here, we report a 52-year-old male patient who had undergone hirudotherapy in his neck and developed infiltrating plaques after four months. A skin biopsy confirmed the diagnosis of Jessner's lymphocytic infiltration. In parallel with the increasing use of hirudotherapy in recent years, the side-effect reports will likely to increase. Indications and contraindications of hirudotherapy, which is being used officially in hospitals, should be taken into consideration.


Assuntos
Aplicação de Sanguessugas/efeitos adversos , Pseudolinfoma/diagnóstico , Dermatopatias/diagnóstico , Diagnóstico Diferencial , Humanos , Masculino , Pessoa de Meia-Idade , Pescoço , Pseudolinfoma/etiologia , Pseudolinfoma/patologia , Dermatopatias/etiologia , Dermatopatias/patologia
12.
Am J Dermatopathol ; 41(9): 675-679, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30839348

RESUMO

Immunoglobulin gamma (Ig) type 4-related disease (IgG4-RD) is a chronic immunologic systemic disorder that has gained worldwide recognition in the past decade. This entity can affect almost every organ system, and its characteristic lesions have been found in a variety of organs such as lacrimal and salivary glands, pancreas, liver, bile ducts, lungs, kidneys, retroperitoneum, breast, aorta, thyroid, and prostate. This case reports a very rare case of IgG4-RD presenting with a cutaneous lesion in a young female patient mimicking a lymphoproliferative disorder. IgG4-RD affecting the skin is a rare entity and has mostly been reported in Japanese men of middle to older age. IgG4-RD with cutaneous involvement should be in the differential of non-neoplastic, lymphomas, autoimmune, and infectious disorders of the skin.


Assuntos
Doenças Autoimunes/patologia , Doença Relacionada a Imunoglobulina G4/imunologia , Doença Relacionada a Imunoglobulina G4/patologia , Pseudolinfoma/patologia , Dermatopatias/patologia , Adolescente , Doenças Autoimunes/imunologia , Biópsia por Agulha , Diagnóstico Diferencial , Grupo com Ancestrais do Continente Europeu , Feminino , Humanos , Doença Relacionada a Imunoglobulina G4/diagnóstico , Imuno-Histoquímica , Pseudolinfoma/diagnóstico , Doenças Raras , Dermatopatias/imunologia , Coxa da Perna/patologia
13.
Gan To Kagaku Ryoho ; 46(3): 540-542, 2019 Mar.
Artigo em Japonês | MEDLINE | ID: mdl-30914607

RESUMO

A60s woman was followed-up regularly for primary biliary cholangitis and a solitary enlarging hepatic mass in the S6 segment of her liver was discovered by ultrasonography. We diagnosed the mass as hepatocellular carcinoma by contrast ultrasonography, contrast computed tomography, and ethoxbenzyl magnetic resonance imaging and laparoscopic partial hepatectomy of S6 segment was performed. The resected specimen was histopathologicaly diagnosed as liver-reactive lymphoid hyperplasia(RLH). The patient is alive without recurrence 17 months after the surgery. Although liver RLH is a rare disease, it should be considered in the differential diagnosis of small liver tumors.


Assuntos
Carcinoma Hepatocelular , Neoplasias Hepáticas , Pseudolinfoma , Carcinoma Hepatocelular/diagnóstico , Feminino , Humanos , Neoplasias Hepáticas/diagnóstico , Recidiva Local de Neoplasia , Pseudolinfoma/diagnóstico
14.
Pediatr Dermatol ; 36(3): 365-367, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30859627

RESUMO

We report a case of benign lymphoplasmacytic plaque (LPP) in a child. These asymptomatic erythematous papulonodular lesions are an emerging clinicopathological entity. Herein, we describe a previously unreported site for LPP lesions, namely, the volar wrist and the distal ipsilateral palm.


Assuntos
Pseudolinfoma/diagnóstico , Pseudolinfoma/terapia , Dermatopatias/diagnóstico , Dermatopatias/terapia , Pré-Escolar , Humanos , Masculino , Pseudolinfoma/etiologia , Dermatopatias/etiologia
17.
J Ultrasound Med ; 38(9): 2379-2388, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30666662

RESUMO

OBJECTIVES: To find certain specifics of hepatic reactive lymphoid hyperplasia (HRLH) on contrast-enhanced ultrasound (CEUS) imaging as diagnostic imaging clues by retrospectively analyzing its enhancement features. METHODS: From June 2010 to June 2017, 18 histopathologically confirmed HRLH lesions in 18 patients were included in this retrospective study. The lesion's location, maximum diameter, shape, margin, echogenicity, and color flow signal on conventional ultrasound (US) imaging and enhancement pattern, presence of a feeding artery, and donutlike enhancement on CEUS imaging were observed and recorded. The lesion size on CEUS imaging at peak enhancement and that on conventional US imaging were compared and recorded. RESULTS: All of the lesions showed homogeneous hypoechogenicity with a regular well-defined margin on conventional US imaging, with a mean diameter ± SD of 14.3 ± 4.6 mm (range, 8-24 mm). On CEUS imaging, all of the lesions showed "quick-wash-in and quick-wash-out," which showed complete homogeneous hyperenhancement in the arterial phase and wash-out in the second half of the arterial phase or first half of the portal phase. In 83.3% (15 of 18) of the lesions, the lesion size that was enhanced at peak was enlarged compared with the hypoechoic area on conventional US imaging, and transient donutlike enhancement appeared when the lesion showed wash-out. In 55.6% (10 of 18) of cases, the feeding artery was detected. CONCLUSIONS: Enlarged complete homogeneous hyperenhancement in the arterial phase, consequently followed by quick wash-out of the lesion and the appearance of donutlike enhancement, may be the CEUS features of HRLH.


Assuntos
Meios de Contraste , Aumento da Imagem/métodos , Hepatopatias/diagnóstico por imagem , Pseudolinfoma/diagnóstico por imagem , Ultrassonografia/métodos , Adulto , Idoso , Feminino , Humanos , Fígado/diagnóstico por imagem , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos
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