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1.
Hautarzt ; 72(4): 354-357, 2021 Apr.
Artigo em Alemão | MEDLINE | ID: mdl-33655344

RESUMO

A cohort of occupational dermatology patients will be set up at the University Hospital Heidelberg, Germany. In a 3-year prospective cohort study, the so-called molecular classifier will be applied in 262 patients to better differentiate between eczema and psoriasis. A retrospective cohort of 282 occupational health patients with the same suspected diagnosis but no molecular classifier designation was used as a control group. In 5 follow-up visits during 3 years, data will be obtained on diagnoses, disease course and severity, absence from work, occupation and quality of life. The research questions address whether early diagnoses will help to better identify the efficient treatment, disease course, absence from work and continuance of occupation. The study is sponsored by the public statutory employers' liability insurance (Deutsche Gesetzliche Unfallversicherung [DGUV]).


Assuntos
Dermatite Ocupacional , Eczema , Dermatoses da Mão , Psoríase , Estudos de Coortes , Eczema/diagnóstico , Eczema/genética , Seguimentos , Alemanha , Humanos , Estudos Prospectivos , Psoríase/diagnóstico , Psoríase/genética , Qualidade de Vida , Estudos Retrospectivos
2.
Medicine (Baltimore) ; 100(5): e23828, 2021 Feb 05.
Artigo em Inglês | MEDLINE | ID: mdl-33592839

RESUMO

ABSTRACT: Dermoscopy is a noninvasive diagnostic technique that is of great value for the differential diagnosis of palmoplantar psoriasis and palmoplantar eczema. Considering the particularity of palmoplantar anatomy, the dermoscopic features of psoriasis and eczema in palm region show fewer differences, compared with those in other parts of the body. Only a few studies have examined the palmoplantar region of psoriasis and eczema patients under a dermoscope.A total of 26 patients with palmoplantar psoriasis and 31 patients with palmoplantar eczema were enrolled in our study. Target palmoplantar areas were observed through general observation and under dermoscope.We found that the presence of white scales and a regular arrangement of dots and globular vessels were significantly indicative of palmoplantar psoriasis, while yellowish scales and an irregular arrangement of atypical vessels were significantly indicative of palmoplantar eczema.


Assuntos
Dermoscopia/métodos , Eczema/diagnóstico , Psoríase/diagnóstico , Adulto , Diagnóstico Diferencial , Feminino , Mãos/patologia , Humanos , Masculino , Ilustração Médica , Sensibilidade e Especificidade
4.
Dermatol Ther ; 34(1): e14691, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33351215

RESUMO

There is widespread concern about treatment of psoriasis in COVID-19 pandemic. We aimed to evaluate the epidemiological data, clinical characteristics, treatment features of the psoriasis patients during the pandemic period. We conducted a study in dermatology clinics of seven different tertiary centers. All adult psoriasis patients who were followed up between 11 March 2020 and 28 June 2020, were phone called or questioned in their visit to their follow-up clinics. A semistructured questionnaire was applied and patients' demographics and disease characteristics were recorded. Of 1322 patients, 52.4% were male, and 47.6% were female. According to the questionnaire responses, 964 (72.9%) of these patients could not communicate with their physician during this period, remained 358 (27.1%) patients contacted the physician by phone, email, or hospital visit. From the patients diagnosed as probable/confirmed COVID-19, 14 were female, and 9 were male. Nine of 23 (39.1%) patients were using biologic treatment. There was no statistically significant difference in terms of hospitalization from COVID-19 between the patients using biologics (n = 9) and those who did not (n = 14) (P = 1.00). No mortality was observed among them. Obesity, smoking, age, and accompanying psoriatic arthritis were not among the risk factors affecting the frequency of COVID-19. We only encountered an increased risk in diabetic patients. Also, an exacerbation of psoriasis was observed with the infection. No difference was found in patients with psoriasis in terms of COVID-19 infection in patients who use biologics and those who don't.


Assuntos
Psoríase , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pandemias , Psoríase/diagnóstico , Psoríase/epidemiologia , Psoríase/etiologia , Psoríase/terapia
5.
Dermatol Ther ; 34(1): e14700, 2021 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-33369063

RESUMO

There are few studies on how patients with psoriasis who are on biologic therapy are affected by the COVID-19 pandemic. We analyzed the impact of the COVID-19 pandemic on patients with psoriasis receiving biologic therapy, patients' current status at a single center in Turkey. A total of 133 patients (mean age; 44.6 ± 13.5 years) were on maintenance biological treatment for moderate-to-severe psoriasis during the pandemic. A standardized questionnaire was administered by phone interviews to determine patients' perceptions, attitudes, and adherence to therapy and identify the frequency of COVID-19 infection, psoriasis status, and new comorbidities during the pandemic. All patients had been receiving a biological agent including ustekinumab, etanercept, adalimumab, secukinumab, infliximab, ixekizumab, or certolizumab pegol. Ninety-one patients (68.4%) had at least one comorbid condition, including psoriatic arthritis (35.3%), hypertension (19.5%), diabetes mellitus (16.5%), obesity, coronary artery disease, and dyslipidemia. During the first 3 months of the pandemic, 52 patients (39%) suspended their biological therapies for short (n = 33) or long (n = 19) periods without medical advice for reasons of fear, worry, and anxiety. All but one patient restarted their medications as a result of therapeutic counseling. Five patients reported suspicious symptoms, but only one had PCR-confirmed COVID-19. Our findings suggest that biologic treatment for moderate-to-severe psoriasis would not pose an additional risk for COVID-19 infection and its life-threatening complications, even in the presence of a high frequency of cardiometabolic comorbidities, provided that all patients are informed and necessary pandemic-directed precautions are well adopted by the patients.


Assuntos
Produtos Biológicos/uso terapêutico , Psoríase , Adulto , Produtos Biológicos/efeitos adversos , Humanos , Pessoa de Meia-Idade , Pandemias , Psoríase/diagnóstico , Psoríase/tratamento farmacológico , Psoríase/epidemiologia , Turquia/epidemiologia
6.
Harefuah ; 159(11): 789-792, 2020 Nov.
Artigo em Hebraico | MEDLINE | ID: mdl-33210847

RESUMO

INTRODUCTION: General pustular pruritus psoriasis (GPPP), also known by the name impetigo herpetiformis, is a rare type of pustular dermatosis which typically occurs in pregnant women during the 3rd trimester and usually regresses after birth. The disease is characterized by acute abruption of erythematous plaque with a disseminated spread of sterile pustule, and may progress to sepsis and even death. Notably, it also carries obstetric complications and is associated with an increase in neonatal morbidity and stillbirth. We present a case report of a patient, and discuss the importance of proper management in this rare condition.


Assuntos
Dermatite Herpetiforme , Impetigo , Complicações Infecciosas na Gravidez , Complicações na Gravidez , Psoríase , Feminino , Humanos , Gravidez , Complicações na Gravidez/diagnóstico , Terceiro Trimestre da Gravidez , Psoríase/complicações , Psoríase/diagnóstico
9.
BMC Dermatol ; 20(1): 6, 2020 08 31.
Artigo em Inglês | MEDLINE | ID: mdl-32867747

RESUMO

BACKGROUND: Specific species of ceramides (Cer), major constituents of lipids in the stratum corneum (SC), are decreased and are correlated with SC barrier and water-holding functions in the skin of patients with atopic dermatitis (AD) or psoriasis (Pso). However, possible correlations between Cer subclass ratios and skin properties in barrier-disrupted skin and in healthy skin remain unclear. The objective of this study was to identify a new marker to evaluate skin properties and epidermal differentiation in SC not only in barrier-disrupted skin but also in healthy skin. METHODS: The Cer subclass ratios in the SC of healthy control subjects and in patients with AD or Pso were evaluated. Correlations with candidate markers and facial skin features of healthy Japanese females (20-74 years old, n = 210) were investigated. Variations of markers during epidermal differentiation were studied in human epidermis and in cultured keratinocytes. RESULTS: The ratios of Cer [NP]/[NS], Cer [NH]/[NS], Cer [NP]/[AS], Cer [NH]/[NS], Cer [NDS]/[AS], Cer [AH]/[AS] and Cer [EOP]/[AS] showed significant differences between non-lesional skin of AD patients and normal skin of healthy control subjects, as well as Pso patients and their healthy control subjects. The Cer [NP]/[NS] ratio was correlated with SC functional parameters (transepidermal water loss and capacitance) and with skin appearance (texture, scaling and color) even in the cheek skin of healthy female subjects. The Cer [NP]/[NS] ratio in the SC was approximately 18-times higher than in living keratinocytes, and it increased as they differentiated. CONCLUSIONS: The Cer [NP]/[NS] ratio in the SC is a potential marker for skin properties and epidermal differentiation in barrier-disrupted skin as well as in healthy skin.


Assuntos
Ceramidas/análise , Dermatite Atópica/patologia , Epiderme/química , Psoríase/patologia , Adulto , Idoso , Biomarcadores/análise , Estudos de Casos e Controles , Diferenciação Celular , Células Cultivadas , Dermatite Atópica/diagnóstico , Epiderme/patologia , Feminino , Humanos , Queratinócitos/química , Queratinócitos/citologia , Lipídeos/análise , Pessoa de Meia-Idade , Psoríase/diagnóstico , Adulto Jovem
15.
Reumatol. clín. (Barc.) ; 16(3): 242-244, mayo-jun. 2020. ilus
Artigo em Espanhol | IBECS | ID: ibc-194359

RESUMO

Se presenta el caso de un paciente de 47 años con antecedente de artritis psoriásica (AP) de 9 años de evolución en quien se encuentra compromiso renal, hipocomplementemia, neuropatía periférica, lesiones necróticas acrales y crioglobulinas positivas. Luego de realizar el abordaje diagnóstico se concluye que el cuadro clínico corresponde a una vasculitis crioglobulinémica concomitante a la AP. Se expone además del caso una revisión de la literatura referente a la presencia de estas 2 enfermedades en un solo paciente


We report the case of a 47-year-old man with a 9-year history of psoriatic arthritis (PsA) in whom we detected renal involvement, hypocomplementemia, peripheral neuropathy, acral necrotic lesions and positive cryoglobulins. The results of the diagnosis led us to conclude that the clinical picture corresponded to cryoglobulinemic vasculitis concomitant with PsA. In addition, we present a review of the literature on the presence of these two diseases in a single patient


Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Vasculite/etiologia , Crioglobulinemia/complicações , Artrite Psoriásica/etiologia , Vasculite/complicações , Vasculite/diagnóstico , Crioglobulinemia/diagnóstico , Psoríase/complicações , Psoríase/diagnóstico , Cotovelo/patologia , Braço/patologia , Metotrexato/uso terapêutico , Glucocorticoides/uso terapêutico , Rituximab/uso terapêutico
19.
J Fam Pract ; 69(4): 192-200, 2020 May.
Artigo em Inglês | MEDLINE | ID: mdl-32437484

RESUMO

Erythema, skin thickening, and scales typify most cases, but other patterns exist. Tx choices may differ, depending on how much body surface area is covered.


Assuntos
Guias de Prática Clínica como Assunto , Psoríase/diagnóstico , Psoríase/epidemiologia , Psoríase/fisiopatologia , Avaliação de Sintomas/métodos , Avaliação de Sintomas/normas , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Índice de Gravidade de Doença , Estados Unidos/epidemiologia , Adulto Jovem
20.
Hautarzt ; 71(9): 699-704, 2020 Sep.
Artigo em Alemão | MEDLINE | ID: mdl-32430542

RESUMO

BACKGROUND: Palmoplantar pustulosis (PPP) is a chronic inflammatory skin disease. Its classification as a variant of psoriasis is controversial. Exogenous factors may affect PPP. OBJECTIVES: Occupational aspects of PPP based on a retrospective evaluation of patient data are discussed. METHODS: Data from 1518 patients who took part in a tertiary prevention program (TIP) for occupational skin diseases in our department between January 2015 and June 2019 were evaluated. RESULTS: PPP was diagnosed in 30 patients (1.98%). The hands were affected in all of them, while concomitant feet involvement was found in 83.3%. The majority was female (70.0%) and reported tobacco smoking (83.3%). Systemic treatment was continued or initiated in one third of patients. In only 8 patients (26.7%) was PPP considered to be work-related. CONCLUSIONS: PPP is an endogenous disease which is influenced by nonoccupational factors (e.g., tobacco smoking). Therefore, a thorough investigation is mandatory when assessing whether occupational factors are legally essential and exceed aggravation by everyday life. For this purpose, a well-documented course of the disease and a critical appraisal of occupational and nonoccupational factors are crucial. Only if occupational causality is probable can preventive measures be provided by the statutory accident insurance and PPP can be legally recognized as an occupational disease.


Assuntos
Dermatoses do Pé , Dermatoses da Mão , Psoríase , Dermatopatias Vesiculobolhosas , Doença Crônica , Feminino , Dermatoses do Pé/diagnóstico , Dermatoses do Pé/genética , Dermatoses da Mão/diagnóstico , Dermatoses da Mão/genética , Humanos , Psoríase/diagnóstico , Psoríase/genética , Estudos Retrospectivos
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