Your browser doesn't support javascript.
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 91
Filtrar
1.
BMC Complement Altern Med ; 19(1): 354, 2019 Dec 05.
Artigo em Inglês | MEDLINE | ID: mdl-31805911

RESUMO

BACKGROUND: Fish oils, which contain omega-3 polyunsaturated fatty acids as the active ingredients, possess anti-inflammatory activities and may have therapeutic potential in diseases with an inflammatory etiology. Fish oil supplement has been advocated for treating psoriasis which is a chronic inflammatory dermatosis. OBJECTIVE: We aimed to investigate the effects of fish oil supplement on psoriasis. METHODS: We searched CENTRAL, Embase and MEDLINE on 24 January 2018 for randomized control trials (RCTs) on the effects of fish oil supplement in treating psoriasis. The Cochrane Collaboration's tool was used to assess the risk of bias of included RCTs. We performed a random-effects model meta-analysis to obtain the pooled treatment effect estimates. RESULTS: We included 13 RCTs with 625 participants. Three RCTs involving 337 participants provided usable data for meta-analysis. Fish oil supplement did not significantly reduce the severity of psoriasis when assessed by Psoriasis Area and Severity Index score (mean difference - 0.28; 95% confidence interval - 1.74 to 1.19). CONCLUSION: The current evidence does not support the use of fish oil supplement in treating psoriasis.


Assuntos
Suplementos Nutricionais , Óleos de Peixe/uso terapêutico , Psoríase/dietoterapia , Ácidos Graxos Ômega-3 , Humanos , Ensaios Clínicos Controlados Aleatórios como Assunto
2.
Dermatol Online J ; 25(2)2019 Feb 15.
Artigo em Inglês | MEDLINE | ID: mdl-30865402

RESUMO

BACKGROUND: Patients with psoriasis have a growing interest in managing their disease through diet. OBJECTIVE: This review paper aims to analyze dietary interventions for psoriasis and their outcome. METHODS: Terms "psoriasis AND diet" were used to search PubMed database and 63 articles describing dietary changes influencing psoriasis were selected. RESULTS: Low calorie diet (LCD) improves Psoriasis Area and Severity Index (PASI) and Dermatology Life Quality Index (DLQI) in conjunction with topical or systemic therapy, although LCD was unsuccessful in maintaining disease remission when patients discontinued concomitant cyclosporine or methotrexate therapy. A fish oil diet improved baseline PASI of 7.7 to 5.3 at three months and 2.6 at 6 months compared to control (PASI: 8.9, 7.8, and 7.8, respectively). A randomized, double-blind, placebo-controlled study investigating selenium supplementation in psoriasis provided no PASI improvement. Zinc supplementation with concomitant betamethasone valerate 0.0025% ointment in a randomized, double-blind, placebo-controlled study provided a mean PASI of 11.2 in the intervention group and 8.0 in the control group with no significant difference between both arms. Gluten free diet and vitamin D supplementation were also efficacious dietary changes although results were mixed. CONCLUSIONS: Dietary changes alone do not cause a large effect in psoriasis but may become an important adjunct to current first line treatments.


Assuntos
Restrição Calórica , Fármacos Dermatológicos/uso terapêutico , Óleos de Peixe/uso terapêutico , Psoríase/dietoterapia , Anti-Inflamatórios/uso terapêutico , Dieta Livre de Glúten , Suplementos Nutricionais , Humanos , Psoríase/tratamento farmacológico , Qualidade de Vida , Selênio/uso terapêutico , Índice de Gravidade de Doença , Zinco/uso terapêutico
3.
Dermatol Ther ; 32(2): e12810, 2019 03.
Artigo em Inglês | MEDLINE | ID: mdl-30632241

RESUMO

Several studies have evaluated the role of individual nutrients on psoriasis. Only a few of them have evaluated the benefits of healthy dietary patterns and the effect of the Mediterranean diet on psoriasis with promising results. Moderate-severe psoriasis is associated with chronic systemic inflammation and increased cardiovascular risk. In this study the present authors measure the adherence to the Mediterranean diet to determine the grade of association with severity of psoriasis, a cardiovascular profile, and systemic inflammation. Our aim was to determine a cut-off point that approximates the real clinical practice by differentiating patients with systemic or biological treatment.


Assuntos
Dieta Mediterrânea/estatística & dados numéricos , Inflamação/dietoterapia , Cooperação do Paciente , Psoríase/dietoterapia , Adulto , Doenças Cardiovasculares/prevenção & controle , Estudos Transversais , Feminino , Humanos , Inflamação/patologia , Masculino , Pessoa de Meia-Idade , Psoríase/patologia , Índice de Gravidade de Doença , Espanha
4.
Eur Rev Med Pharmacol Sci ; 22(23): 8537-8551, 2018 12.
Artigo em Inglês | MEDLINE | ID: mdl-30556896

RESUMO

OBJECTIVE: Several nutritional strategies for the management of psoriasis are promising. Even if recent data support that nutrition may play a pivotal role in prevention and co-treatment and despite patient's concerns regarding the best nutritional habits, the consensus regarding the nutritional strategies to be adopted lacks in clinical settings. In this manuscript, the effects of several nutritional strategies for psoriasis patients such as hypocaloric diet, vitamin D, fish oil, selenium, and zinc supplementation were systematically reviewed. Randomized controlled trials (RCTs) on beneficial botanical oral supplements were also included in the analysis. MATERIALS AND METHODS: For each topic, a search was conducted in MEDLINE electronic databases for articles published in English between January 1, 1990 and September 2018. Two independent reviewers assessed and extracted the data. Only controlled clinical trials were selected. RESULTS: The evidence regarding the current nutritional strategies for psoriasis patients were summarized and translated into a global, comprehensible recommendation. CONCLUSIONS: Weight loss combined with a healthy lifestyle was shown to be very beneficial for patients with moderate to severe disease with a significant reduction of the Psoriasis Area and Severity Index (PASI) score. Currently, oral vitamin D supplementation for prevention or treatment of psoriasis in adults with normal vitamin D levels is not recommended; however, psoriasis patients with a deficit in plasma vitamin D levels are advised to complement with oral supplements to prevent psoriasis-related comorbidities. Instead of zinc, selenium, and omega 3 supplements have been proven beneficial for psoriasis patients. Among botanical species, Dunaliella bardawil (D. bardawil), Tripterygium wilfordii (T. wilfordii), Azadirachta indica (A. indica), Curcuma longa (C. longa), and HESA-A are the most beneficial. In conclusion, a close cooperation between nutritionists and dermatologists may be useful for the management of psoriasis.


Assuntos
Suplementos Nutricionais , Psoríase/dietoterapia , Vitaminas/uso terapêutico , Adulto , Dieta Redutora , Óleos de Peixe , Humanos , Psoríase/tratamento farmacológico , Vitamina D/uso terapêutico
5.
Cutis ; 102(1): 44;46;48, 2018 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-30138495

RESUMO

It is difficult to regulate the abundance of medical information that is available to patients on the Internet. This systematic review evaluated content available online related to diet and 3 dermatologic conditions: acne, psoriasis, and eczema. Ultimately, our results indicated that most of the information that can be found online regarding diet and these dermatologic conditions is unfounded and/or misleading. Although current medical research may support some Internet findings, it is important to advise patients that many results of online searches for medical conditions are unconfirmed.


Assuntos
Internet , Aceitação pelo Paciente de Cuidados de Saúde , Dermatopatias/dietoterapia , Acne Vulgar/dietoterapia , Dermatologia , Dieta , Suplementos Nutricionais , Eczema/dietoterapia , Humanos , Psoríase/dietoterapia , Estados Unidos
6.
JAMA Dermatol ; 154(8): 934-950, 2018 08 01.
Artigo em Inglês | MEDLINE | ID: mdl-29926091

RESUMO

Importance: Psoriasis is a chronic, inflammatory skin disease and has significant associated morbidity and effect on quality of life. It is important to determine whether dietary interventions help reduce disease severity in patients with psoriatic diseases. Objective: To make evidence-based dietary recommendations for adults with psoriasis and/or psoriatic arthritis from the Medical Board of the National Psoriasis Foundation. Evidence Review: We used literature from prior systematic reviews as well as additional primary literature from the MEDLINE database from January 1, 2014, to August 31, 2017, that evaluated the impact of diet on psoriasis. We included observational and interventional studies of patients with psoriasis or psoriatic arthritis. The quality of included studies was assessed using the Newcastle-Ottawa scale for observational studies and the Cochrane Risk of Bias Tool for interventional studies. We made evidence-based dietary recommendations, which were voted on by the National Psoriasis Foundation Medical Board. Findings: We identified 55 studies meeting the inclusion criteria for this review. These studies represent 77 557 unique participants of which 4534 have psoriasis. Based on the literature, we strongly recommend dietary weight reduction with a hypocaloric diet in overweight and obese patients with psoriasis. We weakly recommend a gluten-free diet only in patients who test positive for serologic markers of gluten sensitivity. Based on low-quality data, select foods, nutrients, and dietary patterns may affect psoriasis. For patients with psoriatic arthritis, we weakly recommend vitamin D supplementation and dietary weight reduction with a hypocaloric diet in overweight and obese patients. Dietary interventions should always be used in conjunction with standard medical therapies for psoriasis and psoriatic arthritis. Conclusions and Relevance: Adults with psoriasis and/or psoriatic arthritis can supplement their standard medical therapies with dietary interventions to reduce disease severity. These dietary recommendations from the National Psoriasis Foundation Medical Board will help guide clinicians regarding the utility of dietary interventions in adults with psoriatic diseases.


Assuntos
Artrite Psoriásica/dietoterapia , Dieta , Psoríase/dietoterapia , Adulto , Artrite Psoriásica/patologia , Dieta Redutora , Humanos , Obesidade/complicações , Obesidade/dietoterapia , Sobrepeso/complicações , Sobrepeso/dietoterapia , Psoríase/patologia , Qualidade de Vida , Recomendações Nutricionais , Índice de Gravidade de Doença , Perda de Peso
7.
Complement Ther Clin Pract ; 31: 25-30, 2018 May.
Artigo em Inglês | MEDLINE | ID: mdl-29705464

RESUMO

Psoriasis is a chronic skin disorder that speeds up the life cycle of skin cells, typically on the surface of the skin. Additional skin cells form thick scales and red fixes which are awfully itchy and sometimes painful. Although there are many therapeutic systems available to get symptomatic relief, unfortunately replete cure for psoriasis is not yet reported. Moreover, poor treatment outcomes as well as high toxicity profile of drugs makes these therapies more inconvenient to treat psoriasis. In search of alternative and complementary therapy for this disease, the focus has been shifted to nutraceuticals, few of them were reported since ages. It includes vitamins, herbal extracts, phytochemicals and dietary supplements. In this review, the attempt has been made to highlight key nutraceuticals for better management of psoriasis. Supplementation of appropriate nutraceutical may improve the quality of patient's life and have positive impact on overall state of disease.


Assuntos
Doença Crônica/terapia , Suplementos Nutricionais , Psoríase/dietoterapia , Humanos
8.
Redox Rep ; 23(1): 130-135, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-29630472

RESUMO

Psoriasis is a common, chronic, inflammatory skin disease that affects 2%-4% of the global population. Recent studies have shown that increased oxidative stress (OS) and T-cell abnormalities are central to the pathogenesis of this disease. The resulting reactive oxygen species (ROS) induces proliferation and differentiation of Th17/Th1/Th22 cells and inhibits the anti-inflammatory activities of regulatory T lymphocytes (Treg). Subsequent secretions of inflammatory cytokines, such as interleukin (IL)-17, IL-22, tumor necrosis factor alpha (TNF-α), and interferon-gamma (IFN-γ), and vascular endothelial growth factor (VEGF), stimulate keratinocyte proliferation and angiogenesis. Proanthocyanidins are a class of flavonoids from plants and fruits, and have various antioxidant, anti-inflammatory, and anti-angiogenic properties. Numerous reports have demonstrated therapeutic effects of proanthocyanidins for various diseases. Among clinical activities, proanthocyanidins suppress cell proliferation, prevent OS, and regulate Th17/Treg cells. Because the pathogenesis of psoriasis involves OS and T cells dysregulation, we reviewed the effects of proanthocyanidins on OS, Th17 and Treg cell activities, and keratinocyte proliferation and angiogenesis. Data from multiple previous studies warrant consideration of proanthocyanidins as a promising strategy for the treatment of psoriasis.


Assuntos
Proantocianidinas/uso terapêutico , Psoríase/dietoterapia , Animais , Humanos , Interleucinas/metabolismo , Estresse Oxidativo/efeitos dos fármacos , Psoríase/metabolismo , Linfócitos T Reguladores/efeitos dos fármacos , Linfócitos T Reguladores/metabolismo , Células Th1/efeitos dos fármacos , Células Th1/metabolismo , Células Th17/efeitos dos fármacos , Células Th17/metabolismo
9.
Curr Pharm Des ; 24(10): 1092-1099, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29589537

RESUMO

The epidermis functions as a first-line defense barrier that protects the body from the external environment. As a chemical hindrance, the epidermis possesses acidic pH, highly organized lipids and various host defense peptides, also known as antimicrobial peptides. Human ß-defensins (hBDs), one of the most important host defense peptide families found in our skin, are well-known for their broad-spectrum microbicidal activities. However, there is a growing body of evidence indicating that hBDs also orchestrate several immunomodulatory functions and are the cornerstone that bridges the innate and adaptive immune responses during skin inflammation and infection. Moreover, recent work identified the potential role of hBDs in the regulation and maintenance of the skin barrier function. In this review, we describe the current knowledge concerning the role of hBDs in skin barriers and discuss the potential clinical implications of these peptides in cutaneous biology. Understanding the roles of hBDs in the regulation and maintenance of skin barriers may aid in the development of novel therapeutic strategies for skin conditions where the skin barrier is impaired, such as atopic dermatitis and psoriasis.


Assuntos
Peptídeos Catiônicos Antimicrobianos/farmacologia , Dermatite Atópica/tratamento farmacológico , Psoríase/dietoterapia , Pele/efeitos dos fármacos , beta-Defensinas/farmacologia , Peptídeos Catiônicos Antimicrobianos/química , Dermatite Atópica/imunologia , Humanos , Imunidade Inata/efeitos dos fármacos , Imunidade Inata/imunologia , Psoríase/imunologia , Pele/imunologia , beta-Defensinas/química
10.
Arch Toxicol ; 92(5): 1831-1845, 2018 05.
Artigo em Inglês | MEDLINE | ID: mdl-29594327

RESUMO

Despite the wide consumption of coffee, its anti-inflammatory effect on clinical severity of psoriasis is still debatable. The aim of this study was to evaluate the association between the coffee consumption and clinical severity of psoriasis in a sample of patients stratified according to the presence of the metabolic syndrome (MetS) and smoking. This cross-sectional case-control observational study was conducted on 221 treatment-naïve psoriatic patients. Lifestyle habits, anthropometric measures, clinical and biochemical evaluations were obtained. Clinical severity of psoriasis was assessed by Psoriasis Area and Severity Index (PASI) score. Data on energy caloric intake and coffee consumption were collected using a 7-day food diary record. The coffee consumption was analyzed as coffee intake (consumers and non-consumers) and daily servings (range 0-4 servings/day). Coffee consumers have a lower PASI score vs non-consumers (p < 0.001). The lowest PASI score and MetS prevalence were found in patients consuming 3 cups of coffee/day (p < 0.001), which was also the most common daily serving (34.8%), whereas the highest PASI score was found among those drinking ≥ 4 cups/day. Grouping the case patients according to smoking and MetS, the best odds of PASI score was observed in those drinking 3 cups of coffee per day and no smokers, after adjusting for total energy intake (OR 74.8; p < 0.001). As a novel finding, we reported a negative association between coffee intake, MetS prevalence and clinical severity of psoriasis. The evaluation of the anti-inflammatory effect of coffee on clinical severity of psoriasis, whose metabolic risk increases along with its clinical severity, could be of great importance from a public health perspective.


Assuntos
Café , Síndrome Metabólica/etiologia , Psoríase/etiologia , Adulto , Estudos de Casos e Controles , Fumar Cigarros/efeitos adversos , Estudos Transversais , Feminino , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Psoríase/dietoterapia
11.
Skin Therapy Lett ; 23(1): 1-5, 2018 01.
Artigo em Inglês | MEDLINE | ID: mdl-29357214

RESUMO

An increasing body of research indicates that dietary change may serve as a component of therapy for certain skin conditions. This includes conditions such as acne, atopic dermatitis, aging skin, psoriasis, and rosacea. Certain nutrients, foods, or dietary patterns may act as disease "triggers", while others may prove beneficial. Avoidance or elimination diets may be helpful in some conditions, although testing may be recommended first. In terms of beneficial effects, an eating pattern that emphasizes the consumption of whole foods over highly processed foods may help in the treatment of certain skin conditions, and will certainly help in the prevention of associated co-morbidities.


Assuntos
Dermatopatias/dietoterapia , Dermatite Atópica/dietoterapia , Dieta , Humanos , Psoríase/dietoterapia , Rosácea/tratamento farmacológico , Envelhecimento da Pele
12.
Rev Med Suisse ; 14(588-589): 27-29, 2018 Jan 10.
Artigo em Francês | MEDLINE | ID: mdl-29337444

RESUMO

Fumaric acid has an important role in the citric acid cycle. Its esters were first used by a German chemist to treat his own psoriasis, hypothesizing that the disease may be related to disturbances in this very cycle. Meanwhile, the mechanisms underlying its anti-inflammatory efficacy are much better understood. A monosubstance derived from the mix of esters used originally is now being authorized for treating multiple sclerosis, and in 2017 dimethylfumaric acid ester became a globally available option to treat psoriasis. This very practical therapeutic will most likely become quite popular amongst patients. Therefore, general practitioners might need to familiarize themselves with the profile of this drug, including its potential risks and some very rare but potentially important adverse effects.


Assuntos
Suplementos Nutricionais , Fumaratos , Esclerose Múltipla , Psoríase , Ésteres , Fumaratos/uso terapêutico , Humanos , Esclerose Múltipla/dietoterapia , Psoríase/dietoterapia
16.
Eksp Klin Gastroenterol ; (8): 98-103, 2016.
Artigo em Inglês, Russo | MEDLINE | ID: mdl-29874444

RESUMO

The article demonstrates a clinical case of a child observed over 3 years, whose parents initially complained of non-healing crack between the toes, the navel, the vulva and behind the ears in the appointment of traditionaitherapy. The child in the community conducted a full survey of allergy, the results of which were normative, Ineffective treatment of skin diseases, as well as the presence of family history for autoimmune diseases served as the need for hospitalization of the patient survey. The examination at the clinic revealed higher values of antibodies to tissue transglutaminase and gliadin in the blood, duodenojejunal according to the results of endoscopy and active manifestations of chronic enteritis expressed with total villous atrophy on the long section on the results of morphological study of biopsies of the small intestine mucosa. Based on the results diagnosis of coeliac disease. On the background of a gluten-free diet showed normalization of laboratory and morphological parameters, weight and growth rates, the results of densitometry. However, it was only a slight improvement from the skin lesions. When re-examination of the child set accompanying diagnosis of psoriasis.


Assuntos
Doença Celíaca , Dieta Livre de Glúten , Psoríase , Doença Celíaca/complicações , Doença Celíaca/diagnóstico , Doença Celíaca/dietoterapia , Doença Celíaca/patologia , Pré-Escolar , Feminino , Humanos , Psoríase/complicações , Psoríase/diagnóstico , Psoríase/dietoterapia , Psoríase/patologia
17.
G Ital Dermatol Venereol ; 150(3): 317-20, 2015 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-25946675

RESUMO

Since most of the studies are mainly confined to cases reporting coincidence of psoriasis and celiac disease, the authors want to underline the utility of investigating the possible presence of an underlying celiac disease in normal practice for a better approach to the patient. It is necessary to carry out controlled studies on a large number of patients to evaluate the association between these two diseases and the benefits of a gluten-free diet, even when the intestinal symptomatology is not evident.


Assuntos
Doença Celíaca/dietoterapia , Dieta Livre de Glúten , Psoríase/dietoterapia , Autoanticorpos/sangue , Autoanticorpos/imunologia , Autoantígenos/imunologia , Linfócitos T CD4-Positivos/imunologia , Doença Celíaca/diagnóstico , Doença Celíaca/epidemiologia , Comorbidade , Gerenciamento Clínico , Suscetibilidade a Doenças , Proteínas de Ligação ao GTP/imunologia , Gliadina/efeitos adversos , Gliadina/imunologia , Humanos , Modelos Imunológicos , Estudos Prospectivos , Psoríase/epidemiologia , Psoríase/etiologia , Psoríase/imunologia , Fatores de Tempo , Transglutaminases/imunologia , Resultado do Tratamento , Deficiência de Vitamina D/epidemiologia
20.
Dermatology ; 230(2): 156-60, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-25662711

RESUMO

BACKGROUND: Studies assessing the association between coeliac disease (CD) and psoriasis show conflicting results. OBJECTIVE: To assess in the primary care setting the prevalence of CD in patients with psoriasis and the response to a gluten-free diet (GFD) in subjects with psoriasis and CD. METHODS: We enrolled 218 patients with psoriasis and 264 controls. Coeliac screening was carried out in all subjects (Eurospital, Trieste, Italy). In subjects with a positive serology, the diagnosis of CD was confirmed histologically. RESULTS: Nine (4.1%) psoriatic patients had positive anti-tissue transglutaminase antibodies compared to only 1 among controls (0.4%, p < 0.05; OR 2.03, 95% CI 1.42-90.11). The diagnosis of CD was confirmed histologically in all 10 subjects. At 6 months GFD was associated with a great improvement of skin lesions in 7 out of 8 patients with psoriasis. CONCLUSION: Our multicentre primary care study showed an high prevalence of CD in psoriasis and an improvement of skin lesions in CD under GFD.


Assuntos
Doença Celíaca/dietoterapia , Doença Celíaca/epidemiologia , Dieta Livre de Glúten , Psoríase/dietoterapia , Adulto , Idoso , Autoanticorpos/sangue , Estudos de Casos e Controles , Doença Celíaca/diagnóstico , Feminino , Proteínas de Ligação ao GTP/imunologia , Humanos , Itália/epidemiologia , Masculino , Pessoa de Meia-Idade , Prevalência , Psoríase/sangue , Psoríase/epidemiologia , Transglutaminases/imunologia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA