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Medicine (Baltimore) ; 98(31): e16323, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31374004


The aim of this study was to conduct a more comprehensive analysis of the association between psoriasis and abnormal lipid metabolism.The case-control study included 222 psoriatic patients and 445 non-psoriatic control patients matched for age and gender. Clinical parameters included age, gender, and body mass index (BMI). Serum lipid levels were recorded and included cholesterol (CHO), triglycerides (TG), low-density lipoprotein (LDL), high density lipoprotein (HDL), phospholipids (PLIP), free fatty acids (FFA), lipoprotein (a) [Lp(a)], and apolipoproteins (apoA1, apoB, and apoE). Statistical analysis was carried out through the IBM Statistical Package for the Social Studies version 23.0.Compared with controls, levels of BMI and the prevalence of obesity were significantly higher in psoriatic patients. The results revealed that when compared to controls, significant elevation of serum TG (P <.001) and Lp(a) (P = .022) was observed. Levels of HDL (P <.001) and apoA1 (P <.001) were significantly lower in psoriatic patients. There was no significant difference in CHO (P = .367), LDL (P = .400), apoB (P = .294), apoE (P = .05), PLIP (P = .931) and FFA (P = .554) between patients and controls. The levels of CHO, TG, PLIP, FFA, and apoE were positively correlated with BMI level.Dyslipidemia was more common in psoriatic patients, compared with non-psoriatic controls.

Dislipidemias/etiologia , Obesidade/etiologia , Psoríase/complicações , Adulto , Idoso , Apolipoproteínas B/análise , Apolipoproteínas B/sangue , Apolipoproteínas E/análise , Apolipoproteínas E/sangue , Índice de Massa Corporal , Estudos de Casos e Controles , China/epidemiologia , LDL-Colesterol/análise , LDL-Colesterol/sangue , Dislipidemias/epidemiologia , Dislipidemias/fisiopatologia , Feminino , Humanos , Lisina Acetiltransferase 5/análise , Lisina Acetiltransferase 5/sangue , Masculino , Pessoa de Meia-Idade , Obesidade/epidemiologia , Obesidade/fisiopatologia , Psoríase/epidemiologia , Psoríase/fisiopatologia
Actas dermo-sifiliogr. (Ed. impr.) ; 110(5): 341-346, jun. 2019. tab, ilus, graf
Artigo em Espanhol | IBECS | ID: ibc-180921


La lengua geográfica, también conocida como glositis migratoria benigna, es una condición inflamatoria crónica benigna de la lengua. Se caracteriza por presentar lesiones eritematosas asociadas a una atrofia de papilas, las que están rodeadas por áreas blanquecinas bien delimitadas y localizadas predominantemente en la cara lateral y dorsal de la lengua, lo que da una imagen que recuerda un mapa geográfico. Estas lesiones pueden variar tanto de tamaño como de forma durante su evolución; además, presentan periodos de exacerbación y remisión sin dejar lesiones cicatriciales residuales. La causa de esta entidad sigue siendo desconocida, sin embargo, múltiples asociaciones se han descrito, las que son comentadas a continuación

Geographic tongue, also known as benign migratory glossitis, is a benign chronic inflammatory condition of the tongue. It is characterized by erythematous lesions with filiform papillae atrophy, surrounded by white limited areas in the dorsal and lateral aspects of the tongue, producing a map-like aspect. This lesions change in size and shape with time, and are characterized by periods of exacerbation and remission without scaring. The cause is unknown, but multiple associations have been described, which will be discussed below

Humanos , Masculino , Feminino , Pré-Escolar , Glossite Migratória Benigna/etiologia , Língua/fisiopatologia , Glossite Migratória Benigna/diagnóstico , Glossite Migratória Benigna/tratamento farmacológico , Psoríase/fisiopatologia , Hipersensibilidade , Dermatite Atópica , Deficiência de Vitamina D , Doença Celíaca , Desnutrição , Infecção , Sintomas Concomitantes
Biomed Res Int ; 2019: 2171475, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30931322


Objectives: Ankylosing spondylitis (AS) is a chronic disease that decreases mobility, function, and quality of life. This study introduced the "Smart-phone SpondyloArthritis Management System" (SpAMS), an interactive mobile health (mHealth) tool designed for AS/spondyloarthritis (SpA) disease management and used SpAMS data to evaluate clinical characteristics of Chinese patients with AS. Methods: SpAMS integrates patient's and physician's portals in a smart phone application. The Chinese Ankylosing Spondylitis Prospective Imaging Cohort was launched using SpAMS in April 2016. Patient self-assessments were completed online at baseline and at every subsequent clinic visit. Physician-reported assessments and treatments were recorded by rheumatologists during each visit. Results: In total, 1201 patients with AS [mean (SD) age, 30.6 (8.7) years; male, 82.6%] were recruited. Mean (SD) disease duration was 8.4 (6.1) years. Past or current symptoms of acute anterior uveitis (AAU), psoriasis, and inflammatory bowel disease (IBD) were observed in 21.0%, 3.7%, and 9.4% of patients, respectively. AAU and IBD occurred significantly more in patients with symptom duration > 10 years. The most commonly used medications at baseline were nonsteroidal anti-inflammatory drugs (98.2%). Patients using tumour necrosis factor inhibitors accounted for 20.8%, and 66.4% of patients used conventional synthetic disease-modifying antirheumatic drugs. At baseline, 57.2% of patients had inactive disease (ID)/low disease activity (LDA); this rate significantly improved to 79.2% after a mean follow-up of 13.3 (5.9) months. Compared with relapsed patients, new achievers of ID/LDA underwent more online patient assessments (P < .001). Problems solved in SpAMS caused 29.1% of clinic visits to a tertiary hospital unnecessary. SpAMS saved an average of 5.3 hours and 327.4 RMB per person on traffic expenses; these expenses equalled 16% of the Chinese monthly disposable personal income. Conclusions: SpAMS is a time- and cost-saving disease management tool that can help patients with AS perform self-management and provide valuable data to clinicians.

Gerenciamento Clínico , Smartphone , Espondilite Anquilosante/epidemiologia , Espondilite Anquilosante/prevenção & controle , Adulto , Antirreumáticos/uso terapêutico , China/epidemiologia , Análise Custo-Benefício , Feminino , Humanos , Doenças Inflamatórias Intestinais/tratamento farmacológico , Doenças Inflamatórias Intestinais/epidemiologia , Doenças Inflamatórias Intestinais/fisiopatologia , Doenças Inflamatórias Intestinais/prevenção & controle , Masculino , Pessoa de Meia-Idade , Psoríase/epidemiologia , Psoríase/fisiopatologia , Psoríase/prevenção & controle , Espondilite Anquilosante/tratamento farmacológico , Espondilite Anquilosante/fisiopatologia , Uveíte Anterior/tratamento farmacológico , Uveíte Anterior/epidemiologia , Uveíte Anterior/fisiopatologia , Uveíte Anterior/prevenção & controle
Turk J Med Sci ; 49(2): 617-623, 2019 Apr 18.
Artigo em Inglês | MEDLINE | ID: mdl-30997977


Background/aim: Psoriasis is a chronic inflammatory disease. The effect of psoriasis on the cardiovascular system has not been studied in children before. We studied ventricular strain and vascular functions to assess early cardiovascular effects of psoriasis during childhood. Materials and methods: The study population consisted of 20 psoriatic and 20 age- and sex-matched control subjects. Two-dimensional echocardiography images, longitudinal and global strain, and carotid and brachial ultrasound studies were performed. Results: The mean age of psoriatic children was 14 ± 0.89 years and that of the controls was 14.05 ± 0.88. There were significant increases in terms of interventricular septum diastolic and left ventricular posterior wall diastolic diameter and decreases in mitral E, mitral A, and E/A values between groups. Tissue Doppler imaging revealed significant differences between groups in terms of lateral annulus E', A', E'/A, isovolumetric contraction time, and ejection time. Aortic stiffness was significantly higher and global circumferential strain and longitudinal strain were significantly lower in the psoriasis group. Carotid intima media thickness and flow-mediated dilatation did not differ significantly between the groups. Conclusion: Cardiac left ventricular and arterial functions are affected in psoriatic children and may be an alarming sign of atherosclerotic heart disease in the long term. Early detection of these changes may be helpful for eliminating other risk factors.

Artérias Carótidas/fisiopatologia , Doença da Artéria Coronariana/etiologia , Psoríase/fisiopatologia , Disfunção Ventricular Esquerda/fisiopatologia , Adolescente , Artérias Carótidas/diagnóstico por imagem , Doença da Artéria Coronariana/fisiopatologia , Doença da Artéria Coronariana/prevenção & controle , Diagnóstico Precoce , Ecocardiografia , Ecocardiografia Doppler , Elasticidade , Feminino , Humanos , Estudos Longitudinais , Masculino , Psoríase/complicações , Psoríase/diagnóstico por imagem , Medição de Risco , Disfunção Ventricular Esquerda/diagnóstico por imagem
Dermatol Clin ; 37(2): 129-136, 2019 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-30850034


Psoriasis is a common, chronic inflammatory skin disease that is characterized by the formation of sharply demarcated, scaly, erythematous plaques. It affects about 2.2% of the population in the United States and has a large impact on patient quality of life. Many advances have been made in the last few years in the management of psoriasis. Proinflammatory cytokines play major roles in the pathogenesis of disease. Biologic medications targeting the aforementioned cytokines have been developed and studied for the management of psoriatic disease. This article summarizes the newest findings in the management of psoriasis and the various treatment options available.

Anticorpos Monoclonais/uso terapêutico , Psoríase/tratamento farmacológico , Produtos Biológicos/uso terapêutico , Citocinas/antagonistas & inibidores , Citocinas/imunologia , Humanos , Psoríase/imunologia , Psoríase/fisiopatologia
Exp Mol Pathol ; 107: 124-128, 2019 04.
Artigo em Inglês | MEDLINE | ID: mdl-30776356


PURPOSE: Liraglutide, a glucagon-like peptide-1 (GLP-1) analogue, is an antidiabetic drug. It has been shown to improve the Psoriasis Area and Severity Index (PASI) in patients with type 2 diabetes and psoriasis in clinical practice, but the mechanism remains somewhat unclear. We used lipopolysaccharides (LPS) to induce inflammatory response in keratinocytes and explore the mechanism. METHODS: The HaCat cells were incubated with LPS for 16 h and then were treated with liraglutide for 30 min. Cell viability was testing by CCK-8 assay. GLP-1Rs and intracellular signaling pathways were identified by Western blot. The migration of macrophage was detecting by trans-well assay. RESULTS: Liraglutide decreased cell viability in the HaCat cells. Liraglutide restrained the migration of macrophage to the HaCat cells. LPS elevated not only the protein abundance of phospho-IKKα/ß S176/S180, phospho-NF-κB p65, phospho-JAK2, phospho-STAT3 and SOCS3, but also the levels of TNF-α and IL-6 in the HaCat cells. These effects of LPS were reversed by liraglutide. In addition, liraglutide increased phosphorylation of AMPK. The AMPK inhibitor Compound (CC) impaired liraglutide-inhibited p-NF-κB p65 and p-STAT3. CONCLUSIONS: GLP-1 impaired keratinocytes inflammatory signals by activating AMPK and restrained macrophage migration.

Proteínas Quinases Ativadas por AMP/metabolismo , Hipoglicemiantes/farmacologia , Queratinócitos/efeitos dos fármacos , Liraglutida/farmacologia , Psoríase/fisiopatologia , Proteínas Quinases Ativadas por AMP/efeitos dos fármacos , Linhagem Celular , Movimento Celular/efeitos dos fármacos , Sobrevivência Celular/efeitos dos fármacos , Receptor do Peptídeo Semelhante ao Glucagon 1/agonistas , Humanos , Inflamação/metabolismo , Macrófagos/efeitos dos fármacos , Macrófagos/metabolismo
Cutis ; 102(5S): 6-12, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30566550


Psoriasis is a genetically programmed pathologic interaction among skin cells, immunocytes, and numerous biologic signaling molecules that is triggered by environmental stimuli. The immune response is a cellular one; type 1 (TH1) and type 17 (TH17) T cells are activated by IL-12 and IL-23 secreted by antigen-presenting cells (APCs) in the skin. Through various cytokines, such as tumor necrosis factor (TNF) α, these cells cause a chronic inflammatory state and alter epidermal hyperproliferation, differentiation, apoptosis, and neoangiogenesis that produce the cutaneous findings seen in this disease. The newer biologic therapies target the immunologic signaling pathways and cytokines identified in the pathogenesis of psoriasis and provide notable clinical improvement. Further study in the pathogenesis of psoriasis can help identify targets for future therapies.

Psoríase/imunologia , Psoríase/fisiopatologia , Humanos , Psoríase/genética
Skin Pharmacol Physiol ; 31(6): 308-315, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30184523


Psoriasis is prone to relapses and requires long-term therapy that may induce a range of adverse effects; therefore, an efficient and early detection of relapses is desirable. In this study, photoacoustic imaging and confocal laser scanning microscopic (CLSM) methods were investigated for their suitability in psoriasis follow-up examinations. Using a high-resolution photoacoustic system, the vascular structures of 11 psoriatic patients and 6 healthy volunteers were investigated. No differences were detected with respect to the average vessel diameter and vasculature per unit volume in the tissue of healthy volunteers and non-lesional and lesional skin areas of psoriatic patients. By means of CLSM, the diameters of the dermal papillae of 6 volunteers and 6 psoriatic patients were determined. The diameters of the dermal papillae of the healthy volunteers (0.074 ± 0.006 mm) revealed no significant difference when compared to non-lesional skin areas of psoriatic patients (0.079 ± 0.005 mm). The results obtained for the lesions in psoriatic patients showed a significant difference (Wilcoxon test, p = 0.028) between the diameters of the dermal papillae of the lesional skin areas (0.114 ± 0.012 mm) and the non-lesional skin areas (0.079 ± 0.005 mm). Thus, CLSM can be applied for monitoring psoriasis follow-up examinations.

Psoríase/diagnóstico por imagem , Pele/diagnóstico por imagem , Acústica , Adulto , Feminino , Humanos , Masculino , Microscopia Confocal , Pessoa de Meia-Idade , Psoríase/patologia , Psoríase/fisiopatologia , Pele/irrigação sanguínea , Pele/patologia
J Drugs Dermatol ; 17(6): 657-662, 2018 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-29879253


BACKGROUND: La Roche-Posay Thermal Spring Water (LRP-TSW) exhibits both probiotic and prebiotic properties enhancing the diversity of the skin microbiota. METHODS: A review was undertaken to explore the role of LRP-TSW as a topical probiotic and prebiotic therapy in improving the diversity of the skin microbiota and reducing dryness and pruritus in inflammatory skin diseases. RESULTS: The concentration of minerals and non-pathogenic microbes in LRP-TSW may explain its therapeutic benefit when used for inflammatory skin diseases. Clinical studies have shown that topical LRP-TSW treatment results in increases in Gram-negative bacteria with reduction of Gram-positive bacteria, and improvements in skin microbial diversity. At the same time skin condition in atopic dermatitis, psoriasis, and general dryness in otherwise healthy skin, has been shown to improve. CONCLUSIONS: Enhancement of skin microbiota diversity using topical LRP-TSW may offer a valuable option for the treatment and maintenance of inflammatory skin diseases. J Drugs Dermatol. 2018;17(6):657-662.






Fontes Termais , Hidroterapia/métodos , Microbiota/fisiologia , Prebióticos/administração & dosagem , Probióticos/administração & dosagem , Dermatopatias/terapia , Antioxidantes/administração & dosagem , Dermatite Atópica/microbiologia , Dermatite Atópica/fisiopatologia , Dermatite Atópica/terapia , Humanos , Prurido/microbiologia , Prurido/fisiopatologia , Prurido/terapia , Psoríase/microbiologia , Psoríase/fisiopatologia , Psoríase/terapia , Dermatopatias/microbiologia , Dermatopatias/fisiopatologia
Med. clín (Ed. impr.) ; 150(12): 465-468, jun. 2018. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-173648


Objetivos: La psoriasis se asocia a la disfunción endotelial, lo cual provoca un deterioro del funcionamiento vascular. Los inhibidores del TNF-alpha han mostrado la capacidad de mejorar el funcionamiento vascular en la psoriasis. El índice de resistencia de los vasos ungueales (IRVU) evalúa el funcionamiento microvascular en la uña. El objetivo del estudio fue evaluar el efecto de la inhibición del TNF-alpha con adalimumab en el IRVU. Material y métodos: Estudio cuasiexperimental. Quince pacientes con psoriasis moderada-grave recibieron adalimumab 40mg sc según ficha técnica. Se valoró a los participantes al inicio y a las 12, 24 y 52 semanas tras la intervención del estudio. Resultados: En la semana 52 se observó una reducción del IRVU de −0,09±0,02 (p<0,01) y de −11,2±2,41ng/ml (p<0,001) en la E-selectina. Conclusiones: Adalimumab podría producir una reducción progresiva y sostenida de la resistencia de los vasos ungueales y marcadores de disfunción endotelial

Objectives: Psoriasis is associated to endothelial dysfunction, which causes impaired vascular functioning. TNF-alpha blockers have shown the ability to improve vascular functioning in psoriasis. The nailfold vessel resistance index (NVRI) assesses microvascular functioning at nailfold. The objectives of the study is to assess the effect of the TNF-alpha inhibition with adalimumab on NVRI. Material and methods: Quasi-experimental study. Fifteen patients with moderate-severe psoriasis received adalimumab 40mg sc according to label information. Participants were assessed at baseline and at 12, 24 and 52 weeks after study intervention. Results: A reduction of −0.09±0.02 (P<.01) in NVRI and a −11.2±2,41ng/ml (P<.001) in E-selectin was observed at week 52. Conclusions: Adalimumab could produce a progressive and sustained reduction of vessel resistance at nailfold and E-selectin in patients with psoriasis

Humanos , Masculino , Feminino , Adolescente , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Psoríase/fisiopatologia , Endotélio Vascular/fisiopatologia , Adalimumab , Ultrassonografia Doppler/métodos , Ensaios Clínicos Controlados não Aleatórios como Assunto/métodos , Fator de Necrose Tumoral alfa/antagonistas & inibidores , Microvasos/fisiologia , Unhas/irrigação sanguínea , Biomarcadores , Resistência Vascular , Selectina E
An Bras Dermatol ; 93(2): 197-204, 2018 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-29723361


BACKGROUND: Psoriasis is a chronic, immune mediated inflammatory condition that affects a significant amount of the global population. Yet geographic variability in the consequences of psoriasis warrants region-level analyses. OBJECTIVE: The current study contributes to the psoriasis outcomes literature by offering a comprehensive assessment of the humanistic and economic burden in Brazil. METHODS: The 2012 Brazil National Health and Wellness Survey (N=12,000) was used to assess health-related quality of life (Short Form-12, version 2), work productivity, and healthcare resource use associated with experiencing psoriasis vs. no psoriasis, along with varying levels of psoriasis severity. RESULTS: A total of 210 respondents reported diagnosis of psoriasis (N=157, 42, and 11 reporting mild, moderate, and severe psoriasis, respectively). Compared with controls, respondents with psoriasis reported diminished mental component summary scores and health utilities, as well as increased presenteeism, activity impairment, and physician visits over the past six months, adjusting for covariates. Among those with psoriasis, physical health decreased as psoriasis severity increased. Although work productivity and healthcare resource utilization did not differ with psoriasis severity, the high rates of productivity loss (e.g. 45.5% presenteeism in the severe psoriasis group) suggest an economic burden. STUDY LIMITATIONS: Cost analyses were not performed, and cross-sectional patient-reported data limit causal conclusions and may reflect reporting biases. CONCLUSIONS: Nevertheless, these results suggest a significant burden to patients with psoriasis across both humanistic and economic outcomes. The association between psoriasis and mental health aspects and health utilities were particularly strong and exceeded what would be considered clinically meaningful.

Recursos em Saúde/estatística & dados numéricos , Psoríase/economia , Psoríase/fisiopatologia , Qualidade de Vida , Desempenho Profissional/economia , Adulto , Análise de Variância , Brasil , Estudos de Casos e Controles , Doença Crônica , Efeitos Psicossociais da Doença , Estudos Transversais , Avaliação da Deficiência , Eficiência/fisiologia , Feminino , Inquéritos Epidemiológicos , Humanos , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Psoríase/psicologia , Qualidade de Vida/psicologia , Autorrelato , Índice de Gravidade de Doença , Fatores Socioeconômicos
Med Ultrason ; 20(2): 185-191, 2018 May 02.
Artigo em Inglês | MEDLINE | ID: mdl-29730685


OBJECTIVE: The objective of this study is to evaluate the link between nail fold vessel resistive index (NVRI) measured by ultrasound (US) and capillary loops diameters measured using nailfold videocapillarascopy (NVC), and to assess the morphological appearance of the nail bed in patients with psoriatic nail disease (PND) as compared with healthy controls (HCs). MATERIAL AND METHODS: This study was conducted in patients with PND and HCs. General demographic data were collected and clinical assessments were performed for all subjects. The nail plate thickness (NPT) was measured on gray scale using US. The NVRI was measured using color Doppler (CD) US. The measurements of the apical, arterial, venous limb diameters and morpho-structural changes (tortuous, cross-linked capillaries) were assessed using NVC. RESULTS: Thirty-four patients with PND and 15 HCs were enrolled in this study. The two groups were matched for age and body mass index (BMI). Patients with PND had higher NPT and NVRI in comparison with HCs [(20 (17-23) vs 14 (14-15), p<0.001), (0.55 (0.51-0.61) vs 0.43 (0.38-0.49), p<0.001), respectively]. A higher proportion of patients with PND had tortuous capillaries than HCs (62% and 20% respectively, p=0.005). The mean NVRI was higher in patients with PND who had tortuous capillaries than patients who did not have tortuous capillaries (0.58 (0.7) and 0.52 (0.09), respectively p=0.033). CONCLUSION: Microvascular changes can be detected easily using non-invasive methods such as US and NVC. These methods can provide an objective data to better assess PND.

Microcirculação , Angioscopia Microscópica/métodos , Doenças da Unha/diagnóstico por imagem , Unhas/irrigação sanguínea , Unhas/diagnóstico por imagem , Psoríase/diagnóstico por imagem , Ultrassonografia/métodos , Adulto , Estudos Transversais , Feminino , Humanos , Masculino , Doenças da Unha/complicações , Doenças da Unha/fisiopatologia , Unhas/fisiopatologia , Psoríase/complicações , Psoríase/fisiopatologia , Índice de Gravidade de Doença
Wiad Lek ; 71(3 pt 2): 658-662, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29783242


OBJECTIVE: Introduction: Psoriasis is a skin disease that is accompanied by systemic inflammation and affects about 1 to 5% of the population worldwide. Taking into consideration the data of scientific investigation, at present psoriasis is explained as genetically determined chronic multi factor polysystemic dermatosis. The aim of our research was to determine morphological peculiarities of skin lesions in patients with common psoriasis, investigation of the levels of expression of immunohistochemical markers of vascularization, depending on psoriasis form and severity of the course of pathological processes. PATIENTS AND METHODS: Materials and methods: 93 patients with psoriasis aged from 24 to 58 were observed. The control group consisted of 34 practically healthy people of the same age. Skin biopsy with histological evaluation of biopsy materials was performed for all patients. RESULTS: Results: Analysis of the condition of vascular bed at different levels of severity of psoriasis course showed that a number of cells at moderate degree of severity (22.65±5.87) was considerably higher than at mild psoriasis (10.09±3.22), and even more numerous than in CG (4.32±2.01). We detected a moderate correlation connection between increased intensity of VEGF expression and amplification of the severity of psoriasis course (r = +0.430) and between increased intensity of MMP-9 marker expression and amplification of the severity of psoriasis course (r = +0.532). CONCLUSION: Conclusions: The results of conducted clinical, morphological and immunohistochemical investigations enable to consider importance of neoangiogenesis processes in pathogenesis of this dermatosis and need in elaboration of therapeutic measures with direct influence on this aspect of pathogenesis.

Inflamação/patologia , Neovascularização Patológica , Psoríase/patologia , Adulto , Estudos de Casos e Controles , Quimiocinas/metabolismo , Citocinas/metabolismo , Feminino , Humanos , Imuno-Histoquímica , Inflamação/complicações , Inflamação/fisiopatologia , Masculino , Pessoa de Meia-Idade , Psoríase/complicações , Psoríase/imunologia , Psoríase/fisiopatologia
Taiwan J Obstet Gynecol ; 57(2): 227-230, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-29673665


OBJECTIVE: Psoriasis is a multi-systemic chronic inflammatory skin disease. Previous data suggests that women with some chronic inflammatory diseases have diminished ovarian reserve. This study explores ovarian reserve in patients with psoriasis. MATERIALS AND METHODS: We prospectively analyzed 14 female patients with psoriasis and 35 healthy age and body mass index matched controls. An interview explored demographic characteristics, obstetrical history and menstrual characteristics. Psoriatic area severity index (PASI) in patients was assessed. Estrogen, follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroid stimulating hormone and with gynecologic ultrasonography, ovarian volume and antral follicular count (AFC) were measured in both study and control groups. These values were analyzed with changes of the PASI in the patient group. RESULTS: Patients with psoriasis had significantly higher levels of FSH and FSH/LH ratio than healthy controls (p = 0.039, p = 0.005 respectively). AFC of psoriasis patients were significantly lower than healthy controls (p = 0.002).There were no significant difference among other hormone levels and ovarian volumes (p > 0.05). The hormone levels, ovarian volume and AFC were not correlated with PASI of the patients. CONCLUSION: The results of the study suggest that patients with psoriasis may have diminished ovarian reserve.

Reserva Ovariana , Psoríase/complicações , Adolescente , Adulto , Estradiol/sangue , Feminino , Hormônio Foliculoestimulante/sangue , Humanos , Hormônio Luteinizante/sangue , Pessoa de Meia-Idade , Folículo Ovariano/diagnóstico por imagem , Ovário/diagnóstico por imagem , Estudos Prospectivos , Psoríase/patologia , Psoríase/fisiopatologia , Ultrassonografia
J Biol Regul Homeost Agents ; 32(1): 159-161, 2018 Jan-Feb.
Artigo em Inglês | MEDLINE | ID: mdl-29504381


It is widely accepted that obesity is a systemic comorbidity factor in psoriasis. At the same time, there is rapidly growing evidence that the adipose tissue is not only systemically but also locally involved in the pathophysiology of psoriasis and in response to successful anti-psoriatic treatment.

Obesidade , Psoríase , Gordura Subcutânea , Humanos , Obesidade/metabolismo , Obesidade/patologia , Obesidade/fisiopatologia , Psoríase/metabolismo , Psoríase/patologia , Psoríase/fisiopatologia , Gordura Subcutânea/metabolismo , Gordura Subcutânea/patologia , Gordura Subcutânea/fisiopatologia
Eur J Pharmacol ; 828: 26-30, 2018 Jun 05.
Artigo em Inglês | MEDLINE | ID: mdl-29544684


Psoriasis is a chronic inflammatory skin disease characterized by erythema, skin hyperplasia, scales, and keratinocyte hyperproliferation. While the cause of psoriasis is not clearly understood, a dysregulated immune system, especially activation of IL-23/IL-17 axis, has been strongly implicated in the pathogenesis of psoriasis. For example, anti-IL-23 therapy is effective in psoriasis patients, and thus IL-23 is considered as a potential therapeutic target for the treatment of psoriasis. The skin barrier provides protection of the human body against infection from external pathogens. Dysfunction of the skin barrier is also one of the characteristics in psoriasis and is correlated with disease severity. However, there have been no reports regarding the effectiveness of antipsoriatic agents on the skin barrier dysfunction of psoriasis. In this study, we examined the effect of anti-IL-12/IL-23p40 monoclonal antibody (p40 mAb) on dermatitis symptoms and skin barrier dysfunction in mice with imiquimod-induced psoriasis-like dermatitis. We found that p40 mAb suppressed epidermal thickness and increased transepidermal water loss (TEWL) as indicator for skin barrier function with accompanying suppression of IL-23p19, IL-17A, IL-22, and keratin 16 gene expression. These results suggest that p40 mAb is not only effective against dermatitis symptoms but also skin barrier dysfunction in mice with imiquimod-induced psoriasis-like dermatitis. This is the first report on the effect of p40 mAb on skin barrier dysfunction related to psoriasis. Taken together, our results indicate the possibility of new insights as well as the therapeutic potential of anti-IL-23 for the treatment of psoriasis.

Aminoquinolinas/efeitos adversos , Anticorpos Monoclonais/imunologia , Dermatite/imunologia , Interleucina-12/imunologia , Interleucina-23/imunologia , Psoríase/imunologia , Pele/fisiopatologia , Animais , Proliferação de Células/efeitos dos fármacos , Dermatite/patologia , Dermatite/fisiopatologia , Imiquimode , Queratinócitos/efeitos dos fármacos , Queratinócitos/patologia , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Psoríase/patologia , Psoríase/fisiopatologia , Pele/efeitos dos fármacos