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1.
Medicine (Baltimore) ; 99(5): e18971, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-32000426

RESUMO

BACKGROUND: We analyzed the scientific outputs of global atrial fibrillation (AF) researches, developed a model to qualitatively and quantitatively evaluate the AF research productions from 2004 to 2018. METHODS: The data was retrieved from the Web of Science Core Collection (WOSCC) on June 15, 2019. Bibliometrics tools-CiteSpace V (Drexel university, Chaomei Chen) and VOSviewer (Leiden University, van Eck NJ) --were used for bibliometric analyzing published outputs and finding research hotspots. RESULTS: There were a total of 21,839 research articles on AF, and the annual publication rate increased over time from 2004 to 2018. The Journal of Cardiovascular Electrophysiology published the greatest number of articles, and the leading country was the United States. The leading institution was the Mayo Clinic, and the most productive researchers were: LIP GYH, Natale A, Chen SA, DI Biase L, and Kuck KH. The keywords analysis showed that catheter ablation, risk, heart failure, stroke, and management were research hotspots. CONCLUSION: Bibliometric analysis of the literature shows that research on AF continues to be a hot spot, and the clinical treatment of AF is an important research frontier. However, further research and collaboration are needed worldwide. Our findings aim to provide valuable information for the editors of journals that publish research on arrhythmia, and to help researchers identify new perspectives for future researches.


Assuntos
Fibrilação Atrial , Bibliometria , Publicações/estatística & dados numéricos , Pesquisa Biomédica/tendências , Humanos
2.
J Agric Food Chem ; 68(2): 697-698, 2020 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-31773951

RESUMO

Metabolomics is the study of metabolite profiles at the system level. Since its introduction in the early 2000s, metabolomics has greatly contributed to the understanding of the distribution of metabolites in organisms under various physiological conditions. In this comment, we show our research on the temporal development of metabolomics in general and in agricultural, food, and nutritional sciences. According to our investigation, metabolomics develops in a sigmoid kinetics. On the basis of the analysis, we made a prediction on the future of the metabolomics study, which may benefit the research community in the field.


Assuntos
Camellia sinensis/química , Metabolômica/estatística & dados numéricos , Camellia sinensis/metabolismo , Folhas de Planta/química , Folhas de Planta/metabolismo , Publicações/estatística & dados numéricos
3.
Artigo em Russo | MEDLINE | ID: mdl-31626161

RESUMO

AIM: To assess the qualitative and quantitative composition of publications on medical massage, to determine the share of researches among them, and to compare the publication activity of Russian and foreign specialists in this area. MATERIAL AND METHODS: The authors analyzed an original sample of 4532 works published in 1900 to 2019, which met the primary retrieval request 'massage'. The scientific electronic library eLibrary.ru was used as a database. A detailed analysis was carried out among 1522 works, the main content of which was devoted to massage. Publication activity during this period was also assessed. RESULTS AND CONCLUSION: Publication activity has considerably increased since 2001. There have been 4117 publications, i.e. 90.8% of the entire sample. The share of researches in the Russian Internet segment was 17.47% (266 works) from the analyzed sample, which suggests that there is a lack of attention to the topic of medical massage in Russian professional publications and a need for additional investigations in this area.


Assuntos
Internet , Massagem , Publicações/estatística & dados numéricos , Especialização , Humanos , Federação Russa
4.
Medicine (Baltimore) ; 98(41): e17527, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31593127

RESUMO

BACKGROUND: Disparities in health outcomes across countries/areas are a central concern in public health and epidemiology. However, few authors have discussed legends that can be complemental to choropleth maps (CMs) and merely linked differences in outcomes to other factors like density in areas. Thus, whether health outcome rates on CMs showing the geographical distribution can be applied to publication citations in bibliometric analyses requires further study. The legends for visualizing the most influential areas in article citation disparities should have sophisticated designs. This paper illustrates the use of cumulative frequency (CF) map legends along with Lorenz curves and Gini coefficients (GC) to characterize the disparity of article citations in areas on CMs, based on the quantile classification method for classes. METHODS: By searching the PubMed database (pubmed.com), we used the keyword "Medicine" [journal] and downloaded 7042 articles published from 1945 to 2016. A total number of 41,628 articles were cited in Pubmed Central (PMC). The publication outputs based on the author's x-index were applied to plot CM about research contributions. The approach uses two methods (i.e., quantiles and equal total values for each class) with CF legends, in order to highlight the difference in x-indices across geographical areas on CMs. GC was applied to observe the x-index disparities in areas. Microsoft Excel Visual Basic for Application (VBA) was used for creating the CMs. RESULTS: Results showed that the most productive and cited countries in Medicine (Baltimore) were China and the US. The most-cited states and cities were Maryland (the US) and Beijing (China). Taiwan (x-index = 24.38) ranked behind Maryland (25.97), but ahead of Beijing (16.9). China earned lower disparity (0.42) than the US (0.49) and the rest of the world (0.53) when the GCs were applied. CONCLUSION: CF legends, particularly using the quantile classification for classes, can be useful to complement CMs. They also contain more information than those in standard CM legends that are commonly used with other classification methods. The steps of creating CM legends are described and introduced. Bibliometric analysts on CM can be replicated in the future.


Assuntos
PubMed/instrumentação , Saúde Pública/tendências , Publicações/tendências , Algoritmos , Pequim/epidemiologia , Bibliometria , China/epidemiologia , Sistemas de Informação Geográfica/instrumentação , Mapeamento Geográfico , Disparidades nos Níveis de Saúde , Humanos , Maryland/epidemiologia , Publicações/estatística & dados numéricos , Taiwan/epidemiologia , Estados Unidos/epidemiologia
6.
Environ Sci Pollut Res Int ; 26(28): 28817-28828, 2019 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-31377928

RESUMO

A review of energy subsidy research from a bibliometric perspective was conducted. Based on the bibliometric method, a statistical analysis of energy subsidy-related publications from 1997 to 2016 was undertaken using the Science Citation Index (SCI) and Social Science Citation Index (SSCI) databases. A total of 1182 publications were retrieved, with a significant increase in the number of publications observed after 2006. The majority of these publications were within the disciplines of Energy & Fuels and Environmental Science & Ecology. Although the USA and China contributed the most papers, authors from 96 countries were involved in the various studies. The USA was the center of global collaborations, while other countries/territories mainly conducted bilateral or regional collaborations in their research activities. Five of the top 11 most productive institutes were from China, followed by the USA. The frequency of collaborations among institutes was relatively low. However, the institute-keyword 2-mode network showed that institutes had great potential to cooperate on a number of common topics. Five major themes were identified from the co-keywords analysis: general renewable energy research, bio-energies, sustainability, subsidies, and welfare. The findings, as a complement to previous conventional reviews, will be useful in future energy subsidy research.


Assuntos
Publicações/estatística & dados numéricos , Energia Renovável , Bibliometria , China , Bases de Dados Factuais , Humanos
7.
Radiat Res ; 192(4): 353-362, 2019 10.
Artigo em Inglês | MEDLINE | ID: mdl-31390310

RESUMO

There has been ongoing debate and discussion concerning whether the funding source influenced the outcome of research on human health effects from exposure to radiofrequency fields (RF, electromagnetic waves that carry energy as they propagate in air and dense media). In a study of 225 publications, in which we sought to determine a possible association between the funding source(s), quality and outcome in a total of 2,160 genetic damage assessment tests of mammalian cells exposed to RF energy, we made several observations. One finding was that a great majority of researchers had acknowledged government agencies as the funding source (53%, 120 of 225 publications), while a small number of scientists mentioned mobile phone industry as the financial source (9%, 20 of 225 publications). Numerous investigators did not mention the funding source (26%, 58 of 225 publications). Secondly, industry-funded investigations were of better quality and utilized quality control measures, i.e., blind evaluation, adequate description of dosimetry, positive controls and/or sham-exposed controls, compared to those funded by the government. Another observation was that in industry-funded studies, the d values (effect size or standardized mean difference between the cells exposed to RF energy and sham-exposed controls) were consistently lower than in government-funded studies. In addition, compared to government-funded studies, a higher percentage of industry-funded studies reported no difference in genetic damage between RF- and sham-exposed cells (80% for industry-funded studies versus 49% for government-funded studies). Finally, we observed that industry-funded studies were less likely to report an increase in genetic damage in cells exposed to RF energy (10%) compared to government-funded studies (23%). In view of the large difference between the percentage of publications funded by government and industry (53% or 122 of 225 publications for government, compared to 9% or 29 of 225 publications for industry), caution should be used when debating and discussing the above observations. Overall, it is important to include the quality control measures in the investigations, and also mention the funding source in published studies.


Assuntos
Mamíferos , Publicações/economia , Publicações/estatística & dados numéricos , Lesões por Radiação/genética , Ondas de Rádio/efeitos adversos , Radiobiologia/economia , Animais , Humanos , Controle de Qualidade
8.
Evol Anthropol ; 28(4): 166-178, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31343795

RESUMO

With approximately 30% of nonhuman primate species listed as critically endangered, the window of opportunity to conserve primates is closing fast. In this article, we focus on the degree to which publications in field primatology are biased in favor of particular taxa and field sites. We examined more than 29,000 peer-reviewed articles and identified 876 field visits to 349 field sites. We found a highly clumped distribution by site and species. We also examined publication ethical statements and the extent to which they acknowledged local human communities (<5%). Due to a lack of consistency across publications, we provide recommendations for improving ethical statements and for evaluating research impact. Given the plight of primate biodiversity, these results suggest broader coverage of primate species and geographies, as well as more attention to the local human communities whose support is necessary if the intent is to have primate species in the wild in the 22nd century.


Assuntos
Antropologia Física , Espécies em Perigo de Extinção , Primatas , Publicações/estatística & dados numéricos , Pesquisa/estatística & dados numéricos , Zoologia , Animais , Antropologia Física/organização & administração , Antropologia Física/estatística & dados numéricos , Humanos , Zoologia/organização & administração , Zoologia/estatística & dados numéricos
9.
PLoS Negl Trop Dis ; 13(7): e0007483, 2019 07.
Artigo em Inglês | MEDLINE | ID: mdl-31306424

RESUMO

OBJECTIVE: In Peru, the past three decades have witnessed impressive growth in biomedical research catalyzed from a single research university and its investigators who secured international partnerships and funding. We conducted a bibliometric analysis of publications by Peruvian authors to understand the roots of this growth and the spread of research networks within the country. METHODS: For 1997-2016, publications from Web of Science with at least one author affiliated with a Peruvian institution were examined by year, author affiliations, funding agencies, co-authorship linkages, and research topics. RESULTS: From 1997-2016, the annual number of publications from Peru increased 9-fold from 75 to 672 totaling 6032. Of these, 56% of the articles had co-authors from the US, 13% from the UK, 12% from Brazil, and 10% from Spain. Universidad Peruana Cayetano Heredia (UPCH) was clearly the lead research institution noted on one-third of publications. Of the 20 most published authors, 15 were Peruvians, 14 trained at some point at UPCH, and 13 received advanced training abroad. Plotting co-authorships documented the growth of institutional collaborations, the robust links between investigators and some lineages of mentorship. CONCLUSIONS: This analysis suggests that international training of Peruvian physician-scientists who built and sustained longstanding international partnerships with funding accelerated quality research on diseases of local importance. The role of a single research university, UPCH, was critical to advance a culture of biomedical research. Increased funding from the Peruvian Government and its Council for Science, Technology and Innovation will be needed to sustain this growth in the future. Middle-income countries might consider the Peruvian experience where long-term research and training partnerships yielded impressive advances to address key health priorities of the country.


Assuntos
Pesquisa Biomédica , Fortalecimento Institucional , Cooperação Internacional , Universidades , Academias e Institutos , Autoria , Distinções e Prêmios , Bibliometria/história , Bases de Dados Bibliográficas , História do Século XX , História do Século XXI , Humanos , Peru , Publicações/estatística & dados numéricos , Editoração/estatística & dados numéricos , Projetos de Pesquisa , Pesquisadores
10.
J Laryngol Otol ; 133(6): 526-529, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31155013

RESUMO

OBJECTIVE: The ENT Scotland society (formerly known as the Scottish Otolaryngological Society) has two meetings a year and accepts oral presentations from trainees. This study aimed to identify publication rates from these meetings. METHODS: Abstracts of the presentations are published in The Journal of Laryngology and Otology. A structured search on PubMed and Google Scholar was undertaken to identify which presentations from the 2005 to 2014 meetings have been published. RESULTS: Of the 145 abstracts found, 60.7 per cent were presenting clinical research and 44.1 per cent were related to the head and neck subspecialty. Seventy-three abstracts (50.3 per cent) were associated with publication as a peer-reviewed article; otology papers were more likely to be published than those focusing on other subspecialties (64.3 per cent, p = 0.036). No correlation was found between publication and other factors. CONCLUSION: Presentations at the ENT Scotland meetings undergo unbiased peer review and are as likely to be published as those of other conferences.


Assuntos
Otolaringologia , Revisão por Pares , Publicações/estatística & dados numéricos , Congressos como Assunto , Feminino , Humanos , Masculino , Controle de Qualidade , Escócia , Sociedades Médicas , Fatores de Tempo
11.
Nurs Outlook ; 67(6): 680-695, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31204025

RESUMO

OBJECTIVE: The aim of the study was to analyse the literature production on application of bibliometrics in nursing research. METHODS: Historical, descriptive, and exploratory bibliometrics analyses were used. The papers were harvested from the Scopus bibliographical database (Elsevier, Maribor, Netherlands), on November 18th, 2018, using the search string bibliometric* in publication titles, abstracts, and keywords, limited to the subject of nursing, for the period 1970 to 2018. FINDINGS: The search resulted in 531 publications with 18 publications removed after manual inspection of publications abstracts. The literature production trend was positive. The nursing specific historical roots appeared only recently. The United States of America and Spain were the most productive countries, and most papers were published in Nutricion Hospitalaria and the Journal of Advanced Nursing. Descriptive analysis, research evaluation, content analysis, citation analyses, and trend analysis in nursing research were the most prolific themes. CONCLUSIONS: Applications of bibliometric in nursing is comparable to bibliometrics use in general, however there are some gaps including the use of altmetrics and of Big Data analysis.


Assuntos
Bibliometria/história , Pesquisa em Enfermagem/história , Pesquisa em Enfermagem/estatística & dados numéricos , Publicações/história , Publicações/estatística & dados numéricos , Relatório de Pesquisa/história , História do Século XX , História do Século XXI , Humanos
12.
BMC Health Serv Res ; 19(1): 340, 2019 May 28.
Artigo em Inglês | MEDLINE | ID: mdl-31138250

RESUMO

BACKGROUND: Nursing and midwifery research activity is an important indicator of the quality of healthcare services and the status of nursing profession. The main aim of this study was to assess the research activity in nursing and midwifery field in Arab countries. METHOD: The current study implemented bibliometric method using Scopus database. The search strategy used country affiliation or journal name or keywords as a strategy to retrieve the required documents. The study period was from 1950 to2017. Analysis included a presentation of bibliometric indicators and VOSviewer mapping of the retrieved data. RESULT: 2935 documents were retrieved making up less than 1% of global nursing and midwifery research output. Of the retrieved documents, 25% were published in high rank (first quartile = Q1) journals. The majority (56.7%) of the retrieved documents were published in the last five years of the study period. The retrieved documents received an average of 6.9 citations per document with an h-index of 47. The total number of authors who took part in publishing the retrieved documents was 10,572, giving an average of 3.6 authors per article. Jordan ranked first in research output. Researchers from Jordan took part in over than one third (1023; 34.9%) of the retrieved documents. Lebanon (35.5%) ranked first in the percentage of documents published in Q1 journals. The United Arab Emirates ranked first in the percentage (67.4%) of publications with international authors. The most active journal involved in publishing nursing research from Arab countries was Life Science Journal (158; 5.4%). The University of Jordan was the most productive institution while the American University of Beirut ranked first in the percentage (36.9%) of documents published in Q1 journals. Author keyword analysis and10 most cited articles showed that non-communicable diseases and nursing education were the focus of nursing research in Arab countries. CONCLUSIONS: Nursing and midwifery research activity in Arab countries has dramatically increased especially over the past five years. Despite this, nursing research is still in its infancy, lagging in quantity and quality compared to developed countries.


Assuntos
Tocologia/estatística & dados numéricos , Enfermagem/estatística & dados numéricos , Árabes , Bibliometria , Bases de Dados Factuais/estatística & dados numéricos , Feminino , Humanos , Jordânia , Líbano , Gravidez , Publicações/estatística & dados numéricos , Pesquisa , Emirados Árabes Unidos
13.
Saudi Med J ; 40(5): 426-431, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31056617

RESUMO

OBJECTIVES: To assess the quality of the meta-analyses (MAs) and systematic reviews (SRs) in Saudi journals indexed in PubMed using 2 scales: A MeaSurement tool to assess systematic reviews (AMSTAR) and the overview quality assessment questionnaire (OQAQ). METHODS: This study focused on SRs/MAs published in 8 Saudi journals. We investigated, screened and extracted the data, which included recording the main topic of each SRs/MAs and the date of publication. Furthermore, we assessed the quality of each included SRs/MAs using the AMSTAR and the OQAQ. The reviews concluded in January 2018. Results: The search uncovered 201 unique articles; of these, the researchers screened 110 full texts and included 103 in this review. Most of the included studies were published in Saudi Medical Journal (50 articles, 48.5%), followed by Saudi Journal of Gastroenterology (21 articles, 20.4%), and Annals of Saudi Medicine (16 articles, 15.5%) . The main topics in these published articles were gastroenterology (20 articles, 19.5%), followed by oncology (14 articles, 13.7%), and pharmacology (9 articles, 8.7%). The AMSTAR and the OQAQ scales showed that most SRs/MAs were of medium quality. CONCLUSION: Quality of SRs and MAs published in Saudi journals was distributed in all categories (low, medium, and high) and it can be improved using critical evaluation by authors, journal editors, and readers. PROSPERO REG. NO. CRD: 42018102210.


Assuntos
Confiabilidade dos Dados , Metanálise como Assunto , Publicações Periódicas como Assunto , Publicações/estatística & dados numéricos , Revisão Sistemática como Assunto , Humanos , PubMed , Arábia Saudita , Inquéritos e Questionários , Fatores de Tempo
14.
Glob Health Action ; 12(1): 1606570, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31066343

RESUMO

BACKGROUND: Global health research partnerships, which promote the exchange of ideas, knowledge and expertise across countries, are considered key to addressing complex challenges facing health systems. Yet, many studies report inequalities in these partnerships, particularly in those between high and low-and-middle-income countries (LMICs). OBJECTIVE: This paper examines global research collaborations on community health worker (CHW) programmes, specifically analysing the structures of authorship teams and networks in publications reporting research on CHW programmes in low-income countries (LICs). METHODS: A sub-set of 206 indexed journal articles reporting on CHW programmes in LICs was purposefully selected from a prior review of research authorship on CHW programmes in all LMICs over a five year period (2012-2016). Data on country and primary organisational affiliation and number of publications for all individual authors, programme area (e.g. maternal child health) and total citations per paper were extracted and coded in excel spreadsheets. Data were then exported and analysed in Stata/ICV.14 and Gephi. RESULTS: The 206 papers were authored by 1045 authors from 299 institutions, based in 43 countries. Half (50.1%) the authors came from LIC-based institutions, 43.8% from high-income country (HIC) institutions, 2.9% from middle-income country (MIC) institutions and 3.2% had different first affiliations in different publications. Authors based in the USA (302) and UK (68) accounted for just over a third (35.4%) of all authors. Partnership patterns revealed a primary mode of North-South collaboration with authors from the US, and to a lesser extent the UK, playing central bridging roles between institutions. Strong network clusters of multiple-affiliated authors were evident in research on MCH and HIV/TB aspects of CHW programmes. CONCLUSION: Knowledge production on CHW programmes in LICs flows predominantly through a pool of connected HIC authors and North-South collaborations. There is a need for strategies harnessing more diverse, including South-South, forms of partnership.


Assuntos
Autoria , Bibliometria , Pesquisa Biomédica/estatística & dados numéricos , Agentes Comunitários de Saúde/estatística & dados numéricos , Saúde Global , Colaboração Intersetorial , Publicações/estatística & dados numéricos , Adulto , Países em Desenvolvimento , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pobreza
15.
Plast Reconstr Surg ; 143(6): 1798-1806, 2019 06.
Artigo em Inglês | MEDLINE | ID: mdl-31136497

RESUMO

BACKGROUND: Participation in scientific meetings yields multiple benefits, yet participation opportunities may not be equally afforded to men and women. The authors' primary goal was to evaluate the representation of men and women at five major academic plastic surgery meetings in 2017. Secondarily, the authors used bibliometric data to compare academic productivity between male and female physician invited speakers or moderators. METHODS: The authors compiled information regarding male and female invited speakers from meeting programs. Bibliometric data (h-index, m-value) and metrics of academic productivity (numbers of career publications, publications in 2015 to 2016, career peer-reviewed publications, first and senior author publications) for invited speakers were extracted from Scopus and analyzed. RESULTS: There were 282 academic physician invited speakers at the five 2017 meetings. Women constituted 14.5 percent. Univariate analysis showed no differences in h-index, m-value, or numbers of total career publications or first and last author publications at the assistant and associate professor ranks, but higher values for men at the professor level. A model of academic rank based on bibliometric and demographic variables showed male gender significantly associated with increased probability of holding a professor title, even when controlling for academic achievement markers (OR, 2.17; 95 percent CI, 1.61 to 2.92). CONCLUSIONS: Although the impact of women's published work was no different than that of men among junior and midcareer faculty, women constitute a minority of invited speakers at academic plastic surgery meetings. Sponsorship is imperative for achieving gender balance within plastic surgery and to ultimately create more diverse and effective teams to improve patient care.


Assuntos
Congressos como Assunto/estatística & dados numéricos , Cirurgia Plástica/estatística & dados numéricos , Bibliometria , Eficiência , Feminino , Humanos , Masculino , Médicas/estatística & dados numéricos , Publicações/estatística & dados numéricos , Distribuição por Sexo , Estados Unidos
16.
J Glob Health ; 9(1): 010425, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31131100

RESUMO

Background: The high disease burden of respiratory syncytial virus (RSV) infection and renewed focus on developing a vaccine has led to sustained interest in published RSV-related research. The majority of this research comes from Europe and North/Central America and this landscape review aimed to identify and characterize RSV-related research published during 2011-2015 in these geographical areas. Methods: We conducted a literature review on electronic databases Scopus and Web of Science to identify published studies investigating RSV throughout Europe and North/Central America. We stratified RSV-related publications between 2011-2015 by study type, country, research institution and funding body. Results: The annual published output of RSV-related research has increased by 29% over the period 2011-2015. Eighty seven percent (13/15) of the most highly cited papers on RSV during this period were from North America. US universities with the highest number of RSV-related publications included Emory (n = 23), Vanderbilt (n = 23), University of Michigan (n = 21) and Ohio State (n = 20). The UK (n = 125), Netherlands (n = 97) and Spain (n = 76) were major European contributors to RSV-related publications. University Medical Centre Utrecht (n = 40) and Imperial College London (n = 28) were the European universities with the largest number of RSV-related publications. The National Institutes of Health provided funding for one quarter of all RSV-related publications. However, few countries in Eastern Europe, Central America and the Caribbean published RSV-related research. Few epidemiological studies focused on adult populations over 18 years old (n = 28, 7%) with only five publications specifically investigating elderly populations over 65. Conclusions: This review identifies key regions and research institutions which contributed to RSV-related research during 2011-2015 as well as the donor agencies which supported this research. Further research investment is required in a number of countries. More research in the elderly and in high-risk adults is required given the lack of studies pertaining to these populations. Researchers and those commissioning research can use the data from this review to identify productive research institutions and geographical gaps in RSV research.


Assuntos
Pesquisa Biomédica/estatística & dados numéricos , Publicações/estatística & dados numéricos , Vírus Sincicial Respiratório Humano , América Central , Europa (Continente) , Humanos , América do Norte
18.
Int J Cancer ; 145(12): 3370-3375, 2019 12 15.
Artigo em Inglês | MEDLINE | ID: mdl-31087646

RESUMO

Major ethics policies require that human studies be preceded by animal experiments. We probed the extent to which trials testing efficacy of cancer drugs cited preclinical efficacy studies testing the same drug and disease indication. Using a sample of Phase 2 trial publications for novel cancer monotherapies approved by Food and Drug Administration 2005-2007, we conducted a systematic analysis of citations to preclinical efficacy evidence within trial publications. Citations were classified based on whether they "matched" the drug and indication of the trial. Our sample included 179 Phase 2 publications published 2004-2016. At least one preclinical study was cited for 113 of 179 publications (63%); 56 (31%) cited matching preclinical studies, and 74 (41%) did not cite either matching preclinical or matching clinical trial evidence. When excluding evidence that would likely not have been available to investigators before trial launch, 45 trials (25%) cited matching preclinical studies; 91 (51%) did not cite any matched preclinical or clinical, preceding evidence. No relationship between citation of matching and preceding preclinical evidence and trial outcomes was observed (28.4% of nonpositive trials vs. 26.9% of positive trials, p ~ 1). This suggests that many Phase 2 trial publications do not cite matching preclinical efficacy studies. Limited citation either suggests its absence or its exclusion from a publication. To ensure trials rest on a sound ethical basis and that publications support valid inference, journal editors and referees might encourage more complete descriptions of preclinical evidence or, where appropriate, active disclosure of its absence.


Assuntos
Ensaios Clínicos Fase II como Assunto/estatística & dados numéricos , Avaliação Pré-Clínica de Medicamentos/estatística & dados numéricos , Neoplasias/tratamento farmacológico , Publicações/estatística & dados numéricos , Humanos , Projetos de Pesquisa , Estados Unidos , United States Food and Drug Administration/estatística & dados numéricos
19.
Int Immunopharmacol ; 72: 374-384, 2019 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-31030093

RESUMO

OBJECTIVES: To identify the cooperation of authors, countries, and institutions and explore the hot topics and future prospects regarding programmed cell death protein 1 (PD-1) and programmed cell death 1 ligand 1 (PD-L1) research. MATERIALS AND METHODS: Publications on PD-1 and PD-L1 research were retrieved from the Web of Science Core Collection. Bibliometric analyses were performed using VOSviewer 1.6.9, HistCite 2.1, and CiteSpace V software. Network maps were generated to evaluate the collaborations between different authors, countries, and institutions. RESULTS: A total of 7359 articles related to PD-1 and PD-L1 research in the field of cancer were identified. We observed rapid growth in the number of publications since 2014. Oncoimmunology (326, 4.43%) had the highest number of publications, while N Engl J Med (18,828 co-citations, 6.30%) was the most co-cited journal. Hodi FS and Wolchok JD were key researchers. There were active collaborations among the top authors. The USA was the leading contributor in this field with 3496 publications. Active cooperations between countries and between institutions were observed. The main hot topics included matters related to the efficacy and prognosis of various tumors after treatment with PD-1 and/or PD-L1 inhibitors, as well as the activation or expression of important immunological factors targeted at tumors. CONCLUSION: PD-1 and PD-L1 studies have significantly increased after 2014. The USA contributed the most publications. There were active cooperations between authors, countries, and institutions. Further research should expand and develop new topics such as those likely to boost therapeutic strategies for cancer.


Assuntos
Antígeno B7-H1/imunologia , Bibliometria , Pesquisa Biomédica/estatística & dados numéricos , Neoplasias/imunologia , Receptor de Morte Celular Programada 1/imunologia , Humanos , Publicações/estatística & dados numéricos
20.
J Hepatobiliary Pancreat Sci ; 26(6): 201-210, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30980482

RESUMO

Biliary atresia (BA) is a rare cholangiopathy of largely unknown etiology and unpredictable outcome. There has been an increasing number of BA-related publications, which may challenge researchers to determine their actual scientific value. This study aimed to evaluate the global research activity and developments relating to BA using a combination of scientometric methodologies and visualization tools. A comprehensive search strategy for the Web of Science™ database was designed to obtain bibliographic data on scientific BA publications for the timespan 1900-2018. Research output of countries, institutions, individual authors and collaborative networks was analyzed. Semi-qualitative research measures including citation rate and h-index were assessed. Choropleth mapping and network diagrams were used to visualize results. In total, 4,459 publications on BA were identified (88.5% in English), originating from 63 countries. The largest number was published by the USA (n = 991; 22.2%), Japan (n = 667; 15.0%) and the UK (n = 294; 6.6%). The USA combined the highest number of cooperation articles (n = 140). The most productive collaborative network was established between the USA and Canada (n = 17). Scientific papers from the UK received the highest average citation rate (16.7), whereas the USA had the highest country-specific h-index (59). Eighty-eight (2.0%) items were published under the auspices of multicenter consortiums and registries. The most productive institutions and authors were based in the USA, the UK, Japan, France, Canada and Taiwan. BA-related research has constantly been progressing, becoming more multidisciplinary but with main research endeavors concentrated in a few high-income countries. Studies into pathogenesis of BA remain uncommon, but are sorely needed to foster true scientific progress with this rare disease. Hence, international collaborative and translational research should be strengthened to allow further evolution in this field.


Assuntos
Bibliometria , Atresia Biliar , Publicações/estatística & dados numéricos , Pesquisa Biomédica , Humanos , Cooperação Internacional
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