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1.
Zhen Ci Yan Jiu ; 45(1): 15-20, 2020 Jan 25.
Artigo em Chinês | MEDLINE | ID: mdl-32144903

RESUMO

OBJECTIVE: To observe the effects of electroacupuncture (EA) at "Zusanli" (ST36) on the ultrastructure and mitochondrial dynamics of skeletal muscle tissue in spleen qi deficiency rats, so as to explore the partial action mechanism of EA at ST36 for spleen deficiency syndrome. METHODS: Twenty-four male SD rats were randomly divided into 4 groups: normal group, model group, ST36 group and non-acupoint group (n=6 in each group). The model of spleen qi deficiency syndrome was established by improper diet and exhaustive swimming. EA (2 Hz/15 Hz, 0.5 mA) was applied to bilateral ST36 in the ST36 group and non-acupoint in the non-acupoint group for 20 min, once daily for 7 days. The colorimetric method was used to detect the ATP content in skeletal muscle tissue. The ultrastructure changes of skeletal muscle tissue were observed by transmission electron microscopy. The expression levels of optic atrophy 1 (Opa1) and dynamin-related protein 1 (Drp1) mRNA and proteins in the skeletal muscle tissue were determined by fluorescence quantitative real-time PCR and Western blot, respectively. RESULTS: The ATP content in skeletal muscle tissue of model group was significantly lower than that in the normal group (P<0.05), while significantly higher in the ST36 group than that in the model group and non-acupoint group (P<0.05). Transmission electron microscopy showed that a large number of muscle fibers that were ruptured, damaged, and disorganized; moreover, many vacuoles with different sizes, and abnormally shaped or swollen mitochondria were observed in the model group. ST36 treatment improved the disor-dered fiber arrangement, and reduced the population of damaged mitochondria; thus, fused and elongated mitochondria were readily observed. Compared with the model group, there were no obvious improvements in the non-acupoint group. Compared with the normal group, the expression levels of Opa1 and Drp1 mRNAs and proteins in the skeletal muscle tissue were significantly lower in the model group (P<0.05). After the treatment, the expression levels of Opa1 and Drp1 mRNAs and proteins were up-regulated in the ST36 group (P<0.05), and the expression of Drp1 protein was up-regulated in the non-acupoint group (P<0.05).. CONCLUSION: EA at ST36 can correct the imbalance of mitochondrial fission and fusion in skeletal muscle of rats with spleen qi deficiency, thereby improving the damage of mitochondrial structure and function, and leading to an increase of energy metabolism.


Assuntos
Eletroacupuntura , Pontos de Acupuntura , Animais , Masculino , Dinâmica Mitocondrial , Músculo Esquelético , Qi , Ratos , Ratos Sprague-Dawley
2.
Zhongguo Zhen Jiu ; 40(2): 137-41, 2020 Feb 12.
Artigo em Chinês | MEDLINE | ID: mdl-32100497

RESUMO

OBJECTIVE: To verify the clinical effect of laryngopharyngeal reflux (LPR) treated with acupuncture at the acupoints composed on the base of theory of the ascending and the descending of qi. METHODS: A total of 84 patients of LPR were randomized into an observation group and a control group, 42 cases in each one. The conventional treatment was provided in the two groups. Additionally, in the control group, the medication was administered, i.e. esomeprazole tablets (20 mg, twice a day) and mosapride tablets (5 mg, three times a day), consecutively for 14 days. In the observation group, the oral medication was the same as the control group. Besides, acupuncture at the acupoints composed on the base of theory of the ascending and the descending of qi was supplemented. The acupoints were Tiantu (CV 22), Danzhong (CV 17), Zhongwan (CV 12), Zusanli (ST 36), Taichong (LR 3) and Neiguan (PC 6). The acupuncture treatment was given once a day, 5 times a week, consecutively for 10 times in 2 weeks (14 days in total). Before and after treatment, the reflux symptom index (RSI) score, the reflux finding score (RFS) and the time proportion of esophageal pH < 4 in 24 h were compared, and the therapeutic effect was evaluated in the two groups. RESULTS: After treatment, RSI score, RFS, 24 h esophageal pH<4 time proportion were all reduced as compared with those before treatment in the two groups (P<0.05). After treatment, RSI score, RFS, 24 h esophageal pH<4 time proportion in the observation group were lower than those in the control group (P<0.05). The total effective rate was 92.9% (39/42) in the observation group, better than 71.4% (30/42) in the control group (P<0.05). CONCLUSION: On the base of the conventional treatment, acupuncture at the acupoints composed in compliance with the theory of the ascending and the descending of qi combined with western medication contribute to the recovery of gastrointestinal function, effectively control the laryngopharyngeal symptoms and physical signs. The therapeutic effect of this comprehensive therapy is better than the simple treatment with western medication.


Assuntos
Terapia por Acupuntura , Refluxo Laringofaríngeo/terapia , Qi , Pontos de Acupuntura , Benzamidas/uso terapêutico , Esomeprazol/uso terapêutico , Humanos , Morfolinas/uso terapêutico , Resultado do Tratamento
3.
Zhongguo Zhen Jiu ; 40(2): 203-5, 2020 Feb 12.
Artigo em Chinês | MEDLINE | ID: mdl-32100509

RESUMO

Through collecting the 30-year medical experience of professor WANG Fu-chun, the methods of acupuncture manipulation practice were summarized so as to provide the reference for the medical staffs in acupuncture teaching and clinical work. Professor WANG proposes four key elements of acupuncture manipulation practice, i.e. the style of needling practice, the consciousness of needling practice, the strength of needling practice and qi of needling practice. Acupuncture manipulation is a highly operational clinical skill. The knowledge learning from the experience of the instructors is the important way to improve acupuncture techniques. Besides, beginners need to improve their techniques through learning the theories, a large amount of exercises as well as the self-perception.


Assuntos
Terapia por Acupuntura , Acupuntura/educação , Pontos de Acupuntura , Competência Clínica , Humanos , Medicina Tradicional Chinesa , Qi
4.
Zhongguo Zhen Jiu ; 40(2): 207-10, 2020 Feb 12.
Artigo em Chinês | MEDLINE | ID: mdl-32100510

RESUMO

Professor YANG Jun believes that chronic diarrhea is located in the "intestine" and its pathogenesis focuses on the dysfunction of the spleen and the stomach which results in the impairment of qi activity. In the treatment, the comprehensive therapy is adopted, including acupuncture, moxibustion, herbal medicine, cupping method, etc. Regarding acupuncture therapy, Tianshu (ST 25) is selected specially for regulating the spleen and stomach function, Xiabai (LU4) for dispersing the lung qi to stop diarrhea, as well as Yintang (GV 29), Shuigou (GV 26), Chengjiang (CV 24), Qihai (CV 6), Guanyuan (CV 4) and Zhongwan (CV 12) for promoting the circulation of the conception vessel and the governor vessel. Regarding moxibustion therapy, moxibustion is exerted at the abdominal region to regulate qi and blood circulation and unblocking the meridians. Moreover, the retained cupping method is used at Shenque (CV 8) to consolidate the primary qi and the modified sijunzi tang, the herbal decoction is supplemented to tonify the acquired foundation for assisting the congenital one. All of these therapies co-work on promoting and regulating qi activity so as to stop diarrhea.


Assuntos
Terapia por Acupuntura , Diarreia/terapia , Medicamentos de Ervas Chinesas/uso terapêutico , Moxibustão , Qi , Pontos de Acupuntura , Medicina Herbária , Humanos
5.
Medicine (Baltimore) ; 99(3): e18713, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-32011447

RESUMO

BACKGROUND: Lower extremity artery disease (LEAD) is greatly harmful to Type 2 Diabetes Mellitus patients. Traditional Chinese Medicine (TCM) is an alternative therapy to delay the development of macrovascular diseases, but the existing evidence of its efficacy, safety and mechanism of action is insufficient. We report a study protocol of a multi-center, randomized, double-blind, placebo-controlled trial that aims to use well-designed clinical trial to evaluate the efficacy and safety of Chinese herbal medicine (CHM) Shen-Qi Hua-Yu formula, and to explore efficacy mechanism of the TCM granules and the biomarkers of TCM syndrome. METHODS: This is a multi-center, double-blind, randomized, and placebo-controlled study that randomized 120 participants into 2 groups. The treatment group will receive TCM granules and conventional medicine, while the control group will receive placebo in addition to conventional medicine. Two groups will receive 12-week treatment and 48-week follow-up, with a total of 13 visits. Primary efficacy outcomes included ankle brachial index. Secondary efficacy outcomes included fasting plasma glucose, blood lipid, hemorheology indexes, advanced glycation end products, the inner diameter, peak systolic velocity, end diastolic velocity and mean average velocity of the anterior tibial artery, posterior tibial artery and dorsalis pedis artery, and TCM syndrome score. The safety and endpoint outcomes will be evaluated in this trial. The study will explain the biological therapeutic mechanism of Shen-Qi Hua-Yu formula for diabetic LEAD, and try to use Isobaric tags for Relative and Absolute Quantitation (iTRAQ) and Western blot to screen biomarkers of characteristic diagnosis and clinical efficiency evaluation of the TCM syndrome. DISCUSSION: This study is a multi-center, randomized, double-blind, placebo-controlled trial to evaluate the efficacy and safety of CHM in patients with diabetic LEAD, and to interpret the therapeutic mechanism of Shen-Qi Hua-Yu formula in treatment of diabetic LEAD through proteomics technology, and to screen biomarkers with characteristics of TCM diagnosis and clinical efficacy evaluation. On the other hand, to our knowledge, this study may be the first trial of CHM formulas to observe cardiovascular outcomes through long-term follow-up for the treatment of diabetic LEAD, which is of great value. TRIAL REGISTRATION: This study is registered on the Chinese Clinical Trial Registry: ChiCTR1900026372.


Assuntos
Angiopatias Diabéticas/tratamento farmacológico , Medicamentos de Ervas Chinesas/uso terapêutico , Adulto , Idoso , Índice Tornozelo-Braço , Biomarcadores , Glicemia , Diabetes Mellitus Tipo 2/complicações , Método Duplo-Cego , Feminino , Humanos , Lipídeos/sangue , Extremidade Inferior , Masculino , Pessoa de Meia-Idade , Qi , Projetos de Pesquisa , Artérias da Tíbia
6.
Zhongguo Zhong Yao Za Zhi ; 44(15): 3151-3156, 2019 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-31602866

RESUMO

"Qi medicinal herbs" in China refers to a kind of regional national folk herbs related to the treatment of five labors and seven injuries,the last word of which is "Qi". Our study is to sort out and standardize the name and basic confused varieties through the establishment of " Qi medicinal herbs" VFP information database. " Qi medicinal herbs" variety sorting model of " literature research-variety survey-data mining-spatial distribution" was developed by means of literature analysis which the names and varieties of " Qi medicinal herbs" in the literature were summarized and sorted out. The relationship between the distribution of " Qi medicinal herbs" resources and the use of ethnic groups were visualized by Cytoscape 2. 8. 0 software. The information database of " Qi medicinal herbs" involved in 230 kinds of medicinal materials which including 211 species of plants( including varieties) from 66 families. Medicinal materials standard in China have 9 kinds of " Qi medicinal herbs". Among them,there are 31 kinds of " Qi medicinal herbs" with the confusion of " the different names of the same" and " the different substance of the same names". The most used ethnic groups are Tujia,Qiang and Miao. The main efficacy is clearing heat and detoxification,dispelling wind and removing dampness,etc.,and the main treatment is for injury,rheumatic arthralgia and so on. Names and varieties of " Qi medicinal herbs" among Chinese ethnic groups and folk are standardized and sorted out,which is served to promotethe " Qi medicinal herbs" reasonable protection and utilization of resources,and provide effective reference for exploring the information technology and geographical distribution of ethnic medicine and standardizing clinical medication.


Assuntos
Medicamentos de Ervas Chinesas/normas , Plantas Medicinais/classificação , China , Humanos , Medicina Tradicional Chinesa , Qi , Terminologia como Assunto
7.
Zhongguo Zhen Jiu ; 39(9): 932-5, 2019 Sep 12.
Artigo em Chinês | MEDLINE | ID: mdl-31544379

RESUMO

OBJECTIVE: To explore the therapeutic effect and mechanism of acupoint catgut embedding for chloasma in premenopausal women with liver qi stagnation. METHODS: A total of 92 patients of chloasma in premenopausal women with liver qi stagnation were randomized into an observation group and a control group, 46 cases in each one.In the observation group, acupoint catgut embedding was applied at Ganshu (BL 18), Pishu (BL 20), Sanyinjiao (SP 6), also the surrounding acupuncture was performed at facial part, once a week. In the control group, vitamin C (200 mg per time, 3 times a day) and vitamin E (100 mg per time, once a day) were prescribed for oral administration. Both of the two groups were given treatment for 12 weeks. The score of chloasma area and severity index (MASI), the serum levels of follicular stimulating hormone (FSH), leuteinizing hormone (LH) and estradiol (E2) before and after treatment were observed in the two groups, and the clinical effect of the two groups were compared after 3 months of treatment. RESULTS: Finally, 44 cases in the observation group and 43 cases in the control group completed the study. The effective rate in the observation group was 88.6% (39/44), which was higher than 55.8% (24/43) in the control group (P<0.01). Compared before treatment, the MASI scores after treatment were reduced in the two groups (P<0.01, P<0.05), the MASI score in follow-up in the observation group was reduced as compared with after treatment (P<0.01), and the MASI scores after treatment and in follow-up in the observation group were lower than the control group (P<0.01). Compared before treatment, the levels of FSH and LH in follow-up were reduced (P<0.01), there was no significant difference between before treatment and in follow-up in the level of E2 in the observation group (P>0.05). There was no significant difference between before treatment and in follow-up in the levels of FSH, LH and E2 in the control group (P>0.05). In follow-up, the levels of FSH and LH in the observation group were lower than the control group (P<0.01, P<0.05), there was no significant difference in the level of E2 between the two groups (P>0.05). CONCLUSION: Acupoint catgut embedding can improve the clinical symptoms of chloasma in premenopausal women with liver qi stagnation, the mechanism may be related to regulate the serum level of sex hormone to reduce high sensitivity of melanocytes to estrogen.


Assuntos
Pontos de Acupuntura , Terapia por Acupuntura , Melanose , Qi , Categute , Feminino , Humanos , Fígado , Melanose/terapia
8.
Complement Ther Med ; 45: 7-13, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31331585

RESUMO

OBJECTIVES: In Kampo medicine, a traditional medicine pattern(TM1) refers to the complete clinical presentation of the patient at a given moment in time. Candidate herbal formulas are chosen for a chief complaint, and an appropriate formula is determined on the basis of the pattern(TM1) diagnosis. In this study, we demonstrated the importance of accompanying symptoms in diagnosing traditional medicine patterns(TM1). DESIGN: Single centre observational study. SETTING: We analysed data from 524 new patients with a hypersensitivity to cold sensation as their primary diagnosis (mean age 51.6 ± 17.8 years; female ratio 82.1%) who visited the Keio University Hospital Kampo Clinic between 2008 and 2013. MAIN OUTCOME MEASURES: Accompanying symptoms were recorded on the browser-based e-questionnaire system, which contained 128 items. The Japan Society for Oriental Medicine's board certified Kampo specialists diagnosed the traditional medicine patterns(TM1). RESULTS: When participants were classified according to the origin of their cold sensation, there were no differences in their traditional medicine patterns. In contrast, when patients were classified based on the number of accompanying symptoms, a significant difference in the patterns was identified. An increasing number of accompanying symptoms was associated with more frequent qi stagnation and blood stasis pattern(TM1). Patients with a qi stagnation pattern had higher rates of depression and insomnia. In contrast, patients with a blood stasis pattern(TM1), had higher rates of acne, body stiffness, and menstrual abnormality. CONCLUSIONS: Qi stagnation and blood stasis patterns(TM1) are related to a number of different accompanying symptoms in the patients with hypersensitivity to cold sensation.


Assuntos
Sensação/fisiologia , Temperatura Baixa , Bases de Dados Factuais , Medicamentos de Ervas Chinesas/uso terapêutico , Feminino , Humanos , Japão , Masculino , Medicina Kampo/métodos , Pessoa de Meia-Idade , Qi , Distúrbios do Início e da Manutenção do Sono/fisiopatologia , Inquéritos e Questionários
9.
Nan Fang Yi Ke Da Xue Xue Bao ; 39(7): 855-860, 2019 Jul 30.
Artigo em Chinês | MEDLINE | ID: mdl-31340921

RESUMO

OBJECTIVE: To observe the effects of a traditional Chinese medicine (TCM) capsule for replenishing qi, nourishing yin and activating blood on Notch/Hes1 signaling pathway in the renal tissue and vascular endothelial CD34 and CD144 expressions in a rat model of diabetic nephropathy. METHODS: Rat models of early-stage diabetic nephropathy were established by left nephrectomy and high- fat and high- sugar feeding combined with intraperitoneal injection of STZ. The rats were randomized into model group, benazepril group, and high-, moderate-, and low-dose TCM capsule groups for corresponding treatments, with 6 normal rats as the control group. After 8 weeks of drug treatment, blood glucose and 24-h urinary albumin of the rats were measured, and the renal histopathology was observed with HE staining; Hes1 expression in the renal tissue was detected with immunohistochemical staining, and the renal expressions of CD34 and CD144 were detected using Western blotting. RESULTS: Compared with the normal control group, the rat models of diabetic nephropathy showed obvious abnormalities in 24- h urinary albumin and expressions of Hes1, CD34 and CD144d. The TCM capsule at both the high and moderate doses significantly reduced 24-h urinary albumin in the rats; the renal expressions of Hes1 and CD34 was significantly reduced in all the dose groups, and the expression of CD144 was significantly reduced in the high- dose group. Compared with benazepril group, the TCM capsule obviously reduced CD34 expression at all the 3 doses and lowered CD144 expression at the low dose. Histopathologically, the rats in the model group showed glomerular hypertrophy, increased mesenteric matrix, thickening and widening of the mesenteric membrane, and nodular hyperplasia. These pathologies were obviously alleviated by treatment with the TCM capsule at the high and moderate doses. CONCLUSIONS: The Traditional Chinese medicine (TCM) capsule for replenishing qi, nourishing yin and activating blood can reduce Hes1, CD34 and CD144 in kidney tissue of model rats, play a protective role on kidney function and delay the development of DN.


Assuntos
Nefropatias Diabéticas , Medicamentos de Ervas Chinesas , Animais , Medicina Tradicional Chinesa , Qi , Ratos , Transdução de Sinais , Fatores de Transcrição HES-1
10.
J Acupunct Meridian Stud ; 12(4): 111-121, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31351997

RESUMO

Many functional diseases are related to dysautonomia, and heart rate variability has been used to assess dysautonomia. However, heart rate variability has not been studied in Spleen-Qi deficiency syndrome (SQDS). Healthy volunteers (n = 37) and patients with SQDS (n = 67), recruited from the Clinic of the State University of Ecatepec Valley were included in the study. Outcome measures were average heart rate, standard deviation of the normal-to-normal heartbeat intervals, low frequency (LF), high frequency (HF) power, and the LF/HF ratio. Also, intestinal peristalsis, gastrointestinal symptoms (GSs), fatigue, and level of attention were measured. Standard deviation of the normal-to-normal heartbeat intervals (17 ± 2.3%) and HF (14 ± 3.1%) were lower in SQDS patients (17 ± 1.3%) than in healthy volunteers. SQDS patients had higher heart rate, LF power, LF/HF ratio, and fatigue scores (9.6 ± 1.12%, 16 ± 2.1%, 22 ± 3.8%, and 21 ± 4.1%). The fatigue correlated positively with the LF/HF ratio and negatively with HF power. The SQDS group had lower concentration performance (16.2 ± 1.9%) in the d2 test. The intestinal peristalsis showed a reduction (15 ± 1.3%) as compared with control. GS score and peristalsis correlated negatively with HF. Our results suggest that the pathology of SDQS could be associated with a low vagal tone which causes a decrease in peristalsis, increased fatigue, reduced attention, and appearance of GSs.


Assuntos
Frequência Cardíaca , Qi , Baço/fisiopatologia , Deficiência da Energia Yin/fisiopatologia , Adulto , Estudos Transversais , Fadiga/fisiopatologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Deficiência da Energia Yin/diagnóstico
11.
Zhongguo Zhen Jiu ; 39(7): 773-7, 2019 Jul 12.
Artigo em Chinês | MEDLINE | ID: mdl-31286742

RESUMO

In clinical practice, professor LIANG Fan-rong integrates the guiding-qi acupuncture technique of slow insertion and withdrawal of the needle with the thought of needling sensation reaching the affected site. These two theories were recorded in Lingshu: Wuluan (Chapter 34 of Miraculous Pivot). Professor Liang proposes that in acupuncture, both acupuncture physician and patient should be in a tranquilizing state. Firstly, the needle is inserted slowly so as to conduct the reversed turbid qi in yang back to yin. After arrival of qi, with the compound manipulation for promoting qi, qi is guided to the affected site. When the treatment ends, the needle is removed slowly to guide the reversed clear qi in yin back to yang and to guide qi of nutrient and defensive systems back to the original layers. Such acupuncture technique is applicable for various disorders induced by the impairment of qi activity. In clinical practice, it is adopted for the disorders of heart, lung, stomach, intestines, emotions and nervous system, as well as the obstruction disorders of meridians. The ying-spring and shu-stream points of the affected meridians are selected as the main acupoints in prescription. According the theory of four seas and qi street, the corresponding the front-mu, back-shu and he-sea points are combined. In acupuncture, the needle is inserted and withdrawn slowly. After arrival of qi, the needle is manipulated to guide qi to the pathogenic locations.


Assuntos
Terapia por Acupuntura , Meridianos , Pontos de Acupuntura , Humanos , Qi
12.
Trials ; 20(1): 343, 2019 Jun 10.
Artigo em Inglês | MEDLINE | ID: mdl-31182140

RESUMO

BACKGROUND: Spleen qi deficiency (SQD), a syndrome based on traditional Chinese medicine (TCM) theory, is common in patients after radical gastrectomy. SQD manifests with chronic gastrointestinal disorders and systemic symptoms and is challenging to manage. Hou Gu Mi Xi (HGMX) is a dietary TCM formula for SQD. This study aims to evaluate the efficacy and safety of HGMX in patients with SQD who have undergone radical gastrectomy for gastric cancer. METHODS AND DESIGN: This study is a multicenter, randomized, double-blind, placebo-controlled trial. One hundred thirty patients with SQD who have undergone radical gastrectomy for gastric cancer will be assigned to receive either HGMX or placebo for 2 years. The main outcome will be changes in SQD symptoms assessed by the Spleen Qi Deficiency Symptoms Grading and Quantifying Scale. The secondary outcomes will be changes in quality of life assessed by the Short Form 36 scale, performance status as assessed by the Eastern Cooperative Oncology Group Performance Status scale, body weight, and body mass index. Progression-free survival will also be assessed as a secondary outcome. Adverse events (AEs), severe AEs, and study withdrawal due to AEs will be recorded to evaluate the safety of HGMX. DISCUSSION: The results of this trial will provide initial evidence for the use of HGMX as an alternative and complementary intervention to manage chronic postoperative complications in patients who have undergone radical gastrectomy for gastric cancer. TRIAL REGISTRATION: ClinicalTrials.gov, NCT03025152 . Registered on 17 January 2017.


Assuntos
Medicamentos de Ervas Chinesas/uso terapêutico , Gastrectomia/efeitos adversos , Medicina Tradicional Chinesa , Complicações Pós-Operatórias/tratamento farmacológico , Qi , Neoplasias Gástricas/cirurgia , Adulto , Idoso , Método Duplo-Cego , Medicamentos de Ervas Chinesas/efeitos adversos , Humanos , Pessoa de Meia-Idade , Estudos Multicêntricos como Assunto , Ensaios Clínicos Controlados Aleatórios como Assunto
14.
APMIS ; 127(5): 372-384, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31124203

RESUMO

The present review aimed to summarize the effectiveness and features of traditional Chinese medicine (TCM) for the treatment of infectious diseases and to discuss the limitation of the development of TCM. The personalized medicine with TCM exerts a curative effect on viral and bacterial infectious diseases with unique advantages on the improvement of clinical manifestation, pathogen inhibition, and organ recovery during severe and drug-resistant infection. The deficiency of personalized medicine with TCM lies in that the current research design of TCM primarily focuses on the study of the effective components and material basis of Chinese herbs at the cellular, molecular, and genetic level, while ignoring the guidance of the TCM syndrome differentiation theory, which is the core concept of individualized treatment. Personalized medicine with TCM has a broad prospective for infectious diseases due to the specific efficacy and advantages. While the curative effect of individualized treatment with TCM cannot be excluded from the TCM syndrome differentiation theory, the study of personalized medicine with TCM for infectious diseases urgently requires a unified standardization of the clinical syndrome differentiation and the evolution rule of infectious diseases by TCM theory.


Assuntos
Doenças Transmissíveis/tratamento farmacológico , Medicina Tradicional Chinesa , Infecções Bacterianas/tratamento farmacológico , Clima , Humanos , Controle de Infecções , Qi , Viroses/tratamento farmacológico , Ocidente
15.
Zhongguo Zhen Jiu ; 39(5): 462-6, 2019 May 12.
Artigo em Chinês | MEDLINE | ID: mdl-31099214

RESUMO

OBJECTIVE: To compare the clinical efficacy between acupuncture combined with cinesiotherapy cupping and acupuncture combined with conventional cupping for knee osteoarthritis (KOA) with qi stagnation and blood stasis syndrome, and to seek a better solution for KOA. METHODS: A total of 78 patients of KOA with qi stagnation and blood stasis syndrome were randomly divided into an observation group and a control group, 39 cases in each group (3 cases in the observation group and 2 cases in the control group lost contact). Both groups were treated with acupuncture at Neixiyan (EX-LE 4), Dubi (ST 35), Xuehai (SP 10), Liangqiu (ST 34), Heding (EX-LE 2), Zusanli (ST 36), Yinlingquan (SP 9), Yanglingquan (GB 34) and Xuanzhong (GB 39). Based on the acupuncture treatment, the control group was treated with conventional cupping. The No. 4 cupping glass was used for Xuehai (SP 10), Liangqiu (ST 34) and Fengshi (GB 31), while the No. 3 cupping glass was used for Yinlingquan (SP 9), while the cupping with appropriate size was used for ashi points; the cupping glass was retained for 5 min. Based on the acupuncture treatment, the observation group was treated with cinesiotherapy cupping. The selection of acupoint and cupping glass was identical as the control group. The patients were instructed to perform knee flexion-extension, hip abduction-adduction, weight-bearing and other active exercise while cupping; the treatment was given once a day, 10 times as a course of treatment; totally three courses were given with an interval of 2 days between the courses. The patient's symptom scores, pain scores and knee function scores were recorded before and after treatment. The amount of joint effusion was measured by ultrasound; the level of interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) in joint effusion were measured by ELISA. RESULTS: After treatment, the total effective rate in the observation group was 94.4% (34/36), which was significantly higher than 86.5% (32/37) in the control group (P<0.05). Compared before treatment, the symptom scores, pain scores, amount of joint effusion and the levels of IL-1, IL-6, TNF-α in joint fluid in both groups all were decreased after treatment, whereas the knee function scores were increased (P<0.05). Compared with the control group, the symptom scores, pain scores, and the levels of IL-1, TNF-α and the amount of joint effusion all were significantly decreased, whereas the knee function scores were increased in the observation group (P<0.05). The level of IL-6 in joint effusion was not significantly different between the observation group and the control group (P>0.05). CONCLUSION: The acupuncture combined with cinesiotherapy cupping could alleviate pain, improve joint function and reduce joint effusion, which is superior to acupuncture combined with conventional cupping.


Assuntos
Terapia por Acupuntura , Osteoartrite do Joelho , Humanos , Articulação do Joelho , Osteoartrite do Joelho/terapia , Qi , Resultado do Tratamento
16.
Zhen Ci Yan Jiu ; 44(4): 293-6, 2019 Apr 25.
Artigo em Chinês | MEDLINE | ID: mdl-31056884

RESUMO

OBJECTIVE: To investigate the clinical effect of shallow acupuncture combined with ear-acupoint pellet-pressing in the treatment of primary insomnia in patients with qi-stagnation constitution. METHODS: A total of 60 primary insomnia outpatients with qi-stagnation constitution were randomly divided into treatment group and control group, with 30 patients in each group. The patients in the control group were given oral Alprazolam tablets once a day, and those in the treatment group given shallow acupuncture of Yintang (EX-HN3), Shangen (inferior to EX-HN3), Anmian (EX-HN16) and bilateral Xingjian (LR2) and bilateral Taichong (LR3), once a day, and combined with pellet-pressing of ear acupoints "Shenmen""Sympathy""Subcortex""Heart" and "Liver" once every other day. Each course of treatment was 10 consecutive days, and both groups were treated for three courses. The sleep quality was assessed using Pittsburgh Sleep Quality Index (PSQI), the emotional status assessed using Self-rating Depression Scale (SDS), and the qi-stagnation state evaluated according to "the Criteria for Classification and Judgement of Constitution of Traditional Chinese Medicine (2009)". The therapeutic effect was evaluated according to "the Criteria for Diagnosis and Evaluation of Therapeutic Effect of Diseases of Traditional Chinese Medicine".. RESULTS: Of the two 30 cases in the control and treatment groups, 2 (6.7%) and 6 (20.0%) were cured, 6 (20.0%) and 14 (46.7%) experienced marked improvement in their symptoms, 21 (70.0%) and 6 (20.0%) were effective, and 1 (3.3%) and 4 (13.3%) ineffective, with the effective rate being 86.7% and 96.7%, respectively. No significant difference was found between the two groups in the short-term effect (P>0.05). One month's follow-up showed that, of the two 30 cases in the control and treatment groups, 2 (6.7%) and 5 (16.7%) were cured, 4(13.3%) and 14 (46.6%) experienced marked improvement, 10 (33.3%) and 6 (20.0%) were effective, and 14(46.7%) and 5(16.7%) ineffective, with the effective rate being 53.3% and 83.3%, respectively. The long-term therapeutic effect of the treatment group was significantly superior to that of the control group (P<0.05). After the treatment, both PSQI and SDS scores in the two groups, and qi-stagnation score in the treatment group showed a significant reduction in comparison with their own pretreatment (P<0.05), and one-month's follow-up (not the short-term outcome) displayed that the PSQI, SDS and qi-stagnation scores of the treatment group were significantly lower than those of the control group (P<0.05).. CONCLUSION: Shallow acupuncture combined with ear-acupoint pellet-pressing can significantly improve sleep quality, depression symptoms, and pathological constitution in primary insomnia patients with qi-stagnation constitution, possessing a stable long-term clinical effect.


Assuntos
Pontos de Acupuntura , Distúrbios do Início e da Manutenção do Sono , Humanos , Medicina Tradicional Chinesa , Qi , Distúrbios do Início e da Manutenção do Sono/terapia , Resultado do Tratamento
17.
Zhen Ci Yan Jiu ; 44(4): 307-11, 2019 Apr 25.
Artigo em Chinês | MEDLINE | ID: mdl-31056887

RESUMO

There are some records about the needling and moxibustion sensations in Chinese ancient medical literature, in which, the concept of Deqi (qi arrival) and its relationship with the production of therapeutic effects were put forward. The generation of needling or moxibustion sensations is one of the symbol for qi reaching the affected site during the manipulation and is also related to the treatment outcomes. In the present paper, we reviewed current situations about the mechanisms of acupuncture and moxibustion stimulation induced sensations and their relation to the propagated sensation (PS) published in recent 10 years from the following four aspects: 1) the patterns of manifestation of needling sensations (including general sensations, and specific sensations, as well as the practitioner's hand felt heavy, tight, hard-going senses, etc.) and moxibustion sensations (local superficial and deep warmth); 2) modern anatomical and physiological basis (skin, loose and dense connective tissue, free nerve ending, various receptors); 3) neurohumoral mechanism of acupuncture stimulation induced PS phenomenon (mechanical receptors, afferent and efferent nerve fibers, neural center, various neurotransmitters/modulators, chemical substances, etc.); 4) neurohumoral mechanism of moxibustion stimulation induced channel transmission (transient receptor potential vanilloid receptors-heat sensitive receptors, heat-shock protein, immunocytes, etc.). Additionally, the authors also put forward some suggestions about future researches on acupuncture-moxibustion sensations.


Assuntos
Terapia por Acupuntura , Moxibustão , Pontos de Acupuntura , Qi , Sensação
18.
Zhongguo Zhen Jiu ; 39(3): 241-5, 2019 Mar 12.
Artigo em Chinês | MEDLINE | ID: mdl-30942008

RESUMO

OBJECTIVE: To evaluate the clinical efficacy of umbilical moxibustion in the treatment of patients with idiopathic pulmonary interstitial fibrosis complicated with gastroesophageal reflux of lung-spleen qi deficiency. METHODS: A total of 116 patients with idiopathic pulmonary fibrosis complicated with gastroesophageal reflux of lung spleen-deficiency were randomized into an observation group (58 cases) and a control group (58 cases). In the control group, the routine treatment was applied; in the observation group, on the base of the treatment as the control group, the umbilical moxibustion was used. The treatment was given 2 times a week, 2 h each time for 12 weeks, and followed up for 12 weeks after treatment. The composite physiological indicators (CPI), TCM syndrome scores, the St. George respiratory questionnaire score (SGRQ) and 6-minute walk test (6MWT) were compared before and after treatment in the two groups. RESULTS: The improvement of the TCM syndrome scores (cough, post-activity shortness of breath, fatigue, heartburn, acid reflux), CPI score and 6MWT in the observation group was better than those in the control group (all P<0.05). There was no significant difference in the scores of SGRQ scale between the two groups after treatment (P>0.05). There was no significant difference in the scores of CPI scores and syndromes (cough and fatigue) between the two groups at 12 weeks after treatment (all P>0.05). The 6MWT, SGRQ scale scores and syndrome scores (post-activity shortness of breath, acid reflux, heartburn) were better than those in the control group in the follow up (all P<0.05). CONCLUSION: Umbilical moxibustion can improve the ventilation and diffusion function of lung in patients with idiopathic pulmonary fibrosis and gastroesophageal reflux of lung-spleen qi deficiency, reduce clinical symptoms and improve patients' quality of life and activity endurance. And it has long-term effect.


Assuntos
Refluxo Gastroesofágico , Fibrose Pulmonar Idiopática , Moxibustão , Humanos , Fibrose Pulmonar Idiopática/terapia , Qi , Qualidade de Vida , Baço
19.
Zhongguo Zhen Jiu ; 39(2): 128-32, 2019 Feb 12.
Artigo em Chinês | MEDLINE | ID: mdl-30942029

RESUMO

OBJECTIVE: To observe the clinical therapeutic effects of auricular gold-needle therapy on chronic fatigue syndrome of qi deficiency constitution and explore its potential mechanism. METHODS: A total of 120 patients were randomized into an auricular gold-needle therapy group, an auricular point pressure therapy group and a Chinese herb group, 40 cases in each one. Additionally, a health control group (40 cases) was set up, without any intervention. In the auricular gold-needle therapy group, the gold needle was used to stimulate the auricular points on one side and the cowherb seed pressure therapy on the other side. In the auricular point pressure therapy group, the cowherb seed pressure therapy was adopted only on one side. The auricular points were shen (CO10), xin (CO15), fei (CO14), pizhixia (AT4), etc. in the two groups. The auricular points on both sides were used alternatively. The treatment was given once a week, 4 treatments as one course and the consecutive 3 courses of treatment were required. In the Chinese herb group, buzhong yiqi wan was prescribed for oral administration, 6 g, twice a day, the medication for 1 month was as one session and the consecutive 3 sessions of medication were required. Before and after treatment, separately, the clinical symptom score, the levels of the serum immunoglobulins, i.e. IgA, IgG and IgM were observed in the patients of the three groups. The therapeutic effects were evaluated in the three groups. RESULTS: The total effective rate was 90.0% (36/40) in the auricular gold-needle therapy group, better than 80.0% (32/40) in the auricular point pressure therapy group and 82.5% (33/40) in the Chinese herb group (both P<0.05). Before treatment, the clinical symptom scores of the patients in the three groups were obviously higher than the health control group (all P<0.001). After treatment, the symptom scores were all reduced as compared the scores before treatment in the three groups (all P<0.001) and the symptom scores in the auricular gold-needle therapy group were better than the auricular point pressure therapy group and the Chinese herb group (both P<0.01). Before treatment, the levels of serum IgA, IgG and IgM of the patients in the three groups were lower than the health control group (all P<0.001). The levels were all improved after treatment in the three groups (all P<0.01), and the levels in the auricular gold-needle therapy group was better than the auricular point pressure therapy group and the Chinese herb group (all P<0.05). CONCLUSION: The auricular gold-needle therapy achieves the significant therapeutic effects on chronic fatigue syndrome of qi deficiency constitution and its mechanism is probably related to the regulation of immune function.


Assuntos
Terapia por Acupuntura , Síndrome de Fadiga Crônica , Ouro , Humanos , Qi , Resultado do Tratamento
20.
Zhongguo Zhen Jiu ; 39(2): 197-200, 2019 Feb 12.
Artigo em Chinês | MEDLINE | ID: mdl-30942041

RESUMO

"The arrival of qi ensures curative effect" reminds us that the key to acupuncture is "the arrival of qi ". And "arrival of qi " has the dual meanings of "qi arriving at the needles" (getting qi ) and "qi arriving at the pathogenic locations". "Qi arriving at the needles" is the starting point, the nature and strength of the arrival of qi is closely related to the efficacy; "qi arriving at the pathogenic locations" is the end point, so the speed of the qi is an important part of the final effect. This paper mainly discusses the meaning of the above two aspects and its value in improving the efficacy of acupuncture.


Assuntos
Terapia por Acupuntura , Qi , Agulhas
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