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1.
Prax Kinderpsychol Kinderpsychiatr ; 68(6): 503-524, 2019 Sep.
Artigo em Alemão | MEDLINE | ID: mdl-31480946

RESUMO

Differences in Conflict-Based Play Behavior, Socio-Emotional and Cognitive Development of Preterm Children Compared to Full-Term Children at Preschool Age Preterm children are at increased risk for socio-emotional and cognitive developmental difficulties at preschool age. This study investigates whether preterm children (n = 50) at the age of five years show different socio-emotional competencies in conflict situations and in the corresponding conflict resolution capacity in comparison to full-term children (n = 50). For this purpose, the MacArthur Story Stem Battery was used as the central examination method. In addition, parents completed the Strengths and Difficulties Questionnaire to obtain information about the children's behavior; moreover, the Wechsler Preschool and Primary Scale of Intelligence - Third Edition was applied to examine cognitive development. The parental reports did not reveal any behavioral differences between preterm and term children. However, significant group differences regarding their play behavior were detected. In their narratives, preterm children included content themes of interpersonal conflict and dysregulation more frequently compared to term born controls. Concerning empathic and moral themes and narrative coherence, no group difference could be detected. This could indicate that preterm children show no clinically manifest behavioral disorders at preschool age, but differences concerning intrapsychic experience compared to controls. In addition, preterm children had significantly lower IQ scores than term-born controls. Gestational age was a significant predictor of IQ and hyperactivity and attention problems. The results clarify the need for long term clinical follow up of preterm children and should be used to provide more specific care and support.


Assuntos
Comportamento Infantil/psicologia , Cognição , Emoções , Recém-Nascido Prematuro/psicologia , Comportamento Social , Pré-Escolar , Idade Gestacional , Humanos , Recém-Nascido , Testes de Inteligência , Escalas de Wechsler
4.
Medicina (B Aires) ; 79(4): 280-283, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31487248

RESUMO

The purpose of the study was to evaluate the outcome of patients under 18 months diagnosed with neuroblastoma. Between April 2006 and December 2013, 45 consecutive patients followed in Hospital de Pediatría Garrahan, were retrospectively reviewed. With a median age of 9.3 months (1-18 months) N-myc amplification was detected in 5 out of 38 patients, 1p deletion (del1p) in 4 patients, and 11q aberration in one patient. With a median follow-up of 53 (range: 6-109 months), at 24 months the event free survival (EFS) of all patients was 83% (SE 6%) and overall survival (OS) of 88% (SE 5%). Significant difference was found in OS and EFS between patients with stages L1, L2 and Ms vs. stage M (p = 0.01 and p = 0.01 respectively). EFS for each stage: L1 85% (SE 7%), L2 100%, MS 100%, vs. M 55% (SE 16%). OS: L1 90% (SE 6%), L2 100%, MS 100%, vs. M 66% (SE 15%). OS and EFS results are similar to those reported in international studies. However, better identification of biological prognostic factors will warr ant accurate staging and consequently an appropriate treatment.


Assuntos
Antineoplásicos/administração & dosagem , Neuroblastoma/diagnóstico , Neuroblastoma/tratamento farmacológico , Protocolos Antineoplásicos , Feminino , Seguimentos , Humanos , Lactente , Recém-Nascido , Estimativa de Kaplan-Meier , Masculino , Estadiamento de Neoplasias , Neuroblastoma/mortalidade , Prognóstico , Estudos Retrospectivos
5.
J Registry Manag ; 46(1): 4-14, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31490916

RESUMO

PURPOSE: As survival rates for individuals with HIV/AIDS diagnoses increase, cancer is becoming a more prevalent disease in this population. Data regarding the concurrent diagnoses of HIV/AIDS and cancer has not previously been examined and analyzed in the state of Iowa. METHODS: The Iowa Cancer Registry and Iowa Department of Public Health's HIV/AIDS surveillance databases were linked, and matches were identified. Characteristics of Iowans with HIV/AIDS later diagnosed with cancer between 1991 and 2015 were compared to Iowans without HIV/AIDS using proportional incidence ratios (PIRs). RESULTS: 490 patients met inclusion criteria; 91% had AIDS and 9% had HIV only. Compared to individuals without HIV/AIDS, significantly higher PIRs for cancer were found in younger persons, males, African Americans, metropolitan (metro) residents, and Iowans with Medicaid or the uninsured. Specifically, PIRs associated with the following cancers were higher in the population with HIV/AIDS: Kaposi sarcoma, non-Hodgkin lymphomas (NHLs), and squamous cell neoplasms of the anus. When stratified by AIDS-defining cancers and non-AIDS-defining cancers, the main differences were individuals with AIDS-defining cancers had elevated PIRs among those diagnosed between 1991-1998 and had Kaposi sarcoma or Burkitt lymphoma, while those with non-AIDS-defining cancers were diagnosed between 2007-2015 and were diagnosed with anal, male or female genital, lymphoma other than NHL, liver, lung, or other squamous cell neoplasm cancers. When comparing nonmetropolitan (nonmetro) vs metro Iowans with HIV/AIDS, PIRs for nonmetro patients were elevated in those diagnosed with cancer between 50-59 years old, whites, and individuals diagnosed with squamous cell neoplasms. CONCLUSION: Our results indicate Iowans with HIV/AIDS have higher proportions of certain types of cancers compared to the general population and provide baseline information for future initiatives aimed at preventing or detecting cancer among those living with HIV/AIDS.


Assuntos
Infecções por HIV/epidemiologia , Neoplasias/epidemiologia , Sistema de Registros/estatística & dados numéricos , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , Feminino , Infecções por HIV/complicações , Humanos , Incidência , Lactente , Recém-Nascido , Iowa/epidemiologia , Masculino , Pessoa de Meia-Idade , Neoplasias/complicações , Adulto Jovem
6.
Zhonghua Bing Li Xue Za Zhi ; 48(9): 710-714, 2019 Sep 08.
Artigo em Chinês | MEDLINE | ID: mdl-31495092

RESUMO

Objective: To investigate the clinicopathological features, diagnosis, differential diagnosis, treatment and prognosis of pediatric alveolar rhabdomyosarcoma (ARMS). Methods: The clinical and pathological data of 25 pediatric ARMS from 2008 to 2018 in Children's Hospital of Fudan University were collected. This histomorphology was assessed, and FOXO1 gene rearrangement was detected with FISH. The treatment details and outcome were analyzed. Results: There were 13 males and 12 females, with ages range from 19 days to 14 years (median 6 years, mean 6.2 years). The ARMS were located in the limbs (13 cases), head and neck (4 cases), trunk (3 cases), abdominal cavity (3 cases), scrotum (1 case) and perianal region (1 case). The ARMS were classified histologically as classic group (18 cases), solid group (5 cases) and embryonic-alveolar mixed group (2 cases). The typical pathological characteristics were small dark round cells arranged in solid, glandular and papillary patterns. The tumor cells expressed ALK (D5F3) (21/25, 84.0%), muscle origin DES (23/25, 92.0%), myogenin (22/25, 88.0%), MYOD1 (19/25, 76.0%), and in some cases they also expressed neurogenic marker Syn (6/25, 24.0%). FOXO1 gene rearrangement was detected by FISH in 24/25 cases (96.0%). Conclusion: Pediatric ARMS is rare and has unique clinicopathological characteristics, and needs to be differentiated from other common small round cell malignancies in children. ALK, DES, myogenin, MYOD1 immunohistochemistry and FOXO1 gene rearrangement are valuable aid in the diagnosis of ARMS.


Assuntos
Rabdomiossarcoma Alveolar , Rabdomiossarcoma Embrionário , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Imuno-Histoquímica , Lactente , Recém-Nascido , Masculino , Miogenina , Prognóstico
9.
Univ. salud ; 21(2): 166-175, mayo-ago. 2019. tab, graf
Artigo em Espanhol | LILACS, COLNAL | ID: biblio-1004855

RESUMO

Resumen Introducción: El peso al nacer es un importante indicador de salud del recién nacido, de la madre y de las condiciones de salubridad de una sociedad; además es reconocido como la principal causa de morbimortalidad en la infancia. Objetivo: Determinar la asociación entre seguridad alimentaria en el hogar durante el último trimestre del embarazo y el bajo peso al nacer. Materiales y métodos: Estudio de casos y controles; se incluyeron 73 recién nacidos a término con bajo peso y 73 neonatos con peso normal. Se analizaron variables demográficas, clínicas y de seguridad alimentaria. Resultados: El bajo peso al nacer se asoció con la inseguridad alimentaria en el hogar (OR: 19,3; IC 95%: 6,5-56,9), ajustando por hipertensión arterial de la madre, vaginosis, antecedente de ruptura prematura de membranas y malnutrición gestacional por exceso. Conclusiones: Se encontró una asociación importante entre la inseguridad alimentaria en el hogar durante el último trimestre de gestación y el bajo peso al nacer de los neonatos atendidos en el hospital San Pedro de Pasto. La fuerza de la asociación podría subestimarse en ausencia de ajuste por variables clínicas y demográficas.


Abstract Introduction: Birth weight is an important indicator of the health of the newborn and of the mother. It can also be used as a parameter to define sanitary conditions of societies. Low birth weight is well known as the main cause of morbidity and mortality in childhood. Objective: To determine the association between home food security during the last trimester of pregnancy and low birth weight. Materials and methods: A cases and controls study that included 73 full-term newborns with low weight and 73 normal weight neonates. Demographic, clinical and food security variables were analyzed. Results: Low birth weight was associated with home food insecurity (OR: 19.3; CI 95%: 6.5-56.9), when adjusted to mother's arterial hypertension, vaginosis, antecedent of premature rupture of membranes and gestational malnutrition. Conclusions: We found a significant association between home food insecurity during the last gestational trimester and low birth weight of neonates born in San Pedro Hospital, Pasto. The strength of this association could be underestimated in the absence of adjustments to demographic and clinical variables.


Assuntos
Recém-Nascido , Recém-Nascido de Baixo Peso , Colômbia , Segurança Alimentar e Nutricional
10.
Rev. méd. panacea ; 8(2): 82-86, mayo-ago. 2019.
Artigo em Espanhol | LILACS | ID: biblio-1016008

RESUMO

Introducción: En los últimos veinte años se han desarrollado esfuerzos por reducir la morbimortalidad perinatal a través de la mejora en los servicios que se ofertan al binomio madre-niño. Objetivo: Determinar las características maternas, fetales y neonatales de riesgo asociadas a mortalidad neonatal Materiales y métodos: Búsqueda bibliográfica, a través de los motores de búsqueda de Pubmed, Sciencedirect, Redalyc, Cochrane, Researchgate, Tripdatabase, Google Scholar y Elsevier, de artículos publicados con una antigüedad no mayor de 5 años, en idioma español como inglés. Discusión: Durante las últimas dos décadas existen esfuerzos por reducir la mortalidad y morbilidad neonatal a través de la mejora en la atención médica, identificando y reduciendo los factores de riesgo. Ante ello, la comunidad científica ha diseñado diversos estudios para determinar los factores maternos y neonatales asociados a la morbi-mortalidad neonatal. Conclusiones: La morbi-mortalidad neonatal es multifactorial y dependerá, en gran manera, de las características de las poblaciones estudiadas. (AU)


Introduction: In the last twenty years, efforts have been made to reduce perinatal morbidity and mortality through the improvement of the services offered to the mother-child binomial. Objective: To determine the maternal, fetal and neonatal risk characteristics associated with neonatal mortality Methodology: Bibliographic search of published articles, through the search engines of Pubmed, Sciencedirect, Redalyc, Cochrane, Researchgate, Tripdatabase, Google Scholar, and Elsevier, with no more than 5 years old, in Spanish and English. Discussion: During the last two decades, there has been efforts to reduce neonatal mortality and morbidity through improvement in medical care, identifying and reducing risk factors. Given this, the scientific community has designed several studies to determine the maternal and neonatal factors associated with neonatal morbidity and mortality. Conclusions: Neonatal morbidity and mortality is multifactorial and will depend, to a large extent, on the characteristics of the studied populations. (AU)


Assuntos
Humanos , Masculino , Feminino , Recém-Nascido , Fatores de Risco , Morbidade , Mortalidade Perinatal
11.
Rev. méd. panacea ; 8(2): 69-72, mayo-ago. 2019. tab, graf
Artigo em Espanhol | LILACS | ID: biblio-1015988

RESUMO

Objetivo: Determinar el uso de los micronutrientes y grado de anemia en niños menores de 3 años atendidos en un Centro de Salud de Ica 2017. Materiales y métodos: El estudio fue cuantitativo, de tipo descriptivo, y transversal, la muestra estuvo conformada por 40 niños menores de tres años con sus respectivas madres, la técnica que se utilizó fue la observación y el análisis documental. Resultados: En relación a los datos generales de la madre, el 47.5% (19) tienen 19 a 34 años, el 50% (20) tienen instrucción superior, el 40% (16) son solteras y el 57.5% (23) trabaja fuera de casa; sobre los datos del niño, el 55% (22) tienen de 6 a 12 meses, el 72.5% (29) recibió solo lactancia materna hasta los seis meses y el 100% (40) inició la alimentación complementaria a los 6 meses. El uso de micronutrientes es adecuado en el 82.5% (33) de las madres y es inadecuado en el 17.5% (07). Según valores de hemoglobina, el 62.5% (25) de los niños no presentan anemia, el 37.5% (15) presentan anemia leve, no encontrando niños con anemia moderada ni anemia severa. Conclusiones: El uso de micronutrientes que administran las madres a sus niños es adecuado y los niños no presentan anemia en su mayoría, existiendo porcentajes menores de niños con anemia leve por lo que se sugiere que se continúe con el abastecimiento continuo de los micronutrientes realizando campañas educativas a fin de comprometer a las madres en la administración correcta de los micronutrientes en sus menores hijos aprovechando los momentos de contacto con las madres para la educación respectiva en las sala de espera, durante sus controles de inmunizaciones, controles CRED, y realizar un monitoreo periódico del control de hemoglobina. (AU)


Objective: To determine the use of micronutrients and the degree of anemia in children under 3 years of age served in an Ica Health Center 2017. Materials and methods: The study was quantitative, descriptive, and cross-sectional, the sample consisted of 40 children under three years with their respective mothers, the technique used was observation and documentary analysis. Results: In relation to the general data of the mother, 47.5% (19) are 19 to 34 years old, 50% (20) have higher education, 40% (16) are single and 57.5% (23) work ; On the data of the child, 55% (22) have from 6 to 12 months, 72.5% (29) received only breastfeeding until six months and 100% (40) started complementary feeding at 6 months. The use of micronutrients is adequate in 82.5% (33) of mothers and is inadequate in 17.5% (07). According to hemoglobin values, 62.5% (25) of the children do not have anemia, 37.5% (15) have mild anemia, and there are no children with moderate anemia or severe anemia. Conclusions: The use of micronutrients administered by mothers to their children is mostly adequate and children do not have anemia in their majority. There are smaller percentages of children with mild anemia, so it is suggested that continuous supply of the micronutrients conducting educational campaigns in order to engage mothers in the correct administration of micronutrients in their younger children, taking advantage of the moments of contact with mothers for the respective education in the waiting room, during their immunization controls, CRED controls, and perform periodic monitoring of hemoglobin control. (AU)


Assuntos
Humanos , Masculino , Feminino , Recém-Nascido , Lactente , Pré-Escolar , Micronutrientes/uso terapêutico , Anemia , Análise Quantitativa , Epidemiologia Descritiva , Estudos Transversais
12.
Zhonghua Fu Chan Ke Za Zhi ; 54(7): 438-444, 2019 Jul 25.
Artigo em Chinês | MEDLINE | ID: mdl-31365955

RESUMO

Objective: To observe and analysis the changes of hemodynamic parameters and outcomes of pregnant women combined with congenital heart disease-pulmonary arterial hypertension (CHD-PAH). Methods: A prospective analysis of hemodynamic parameters of patients combined with CHD-PAH in Beijing Anzhen Hospital from January 2015 to December 2017 was carried out. Total 99 cases were divided into 4 groups based on systolic pulmonary arterial pressure (SPAP): mild group (SPAP 25-49 mmHg, 1 mmHg=0.133 kPa), moderate group (SPAP 50-79 mmHg), severe group (SPAP≥80 mmHg) and Eisenmenger syndrome group. Results: (1) SPAP of all groups increased during gestation, and the growth rates had no statistical differences (P>0.05). The SPAP in each group decreased after termination but was still higher than the early pregnancy's SPAP. (2) CHD-PAH patients in moderate [2 cm(2) (1-5 cm(2)), 1.0 cm (-2.0 - 2.0 cm)], severe [5 cm(2) (3-9 cm(2)), -3.5 cm (-6.0 - 1.0 cm)] or Eisenmenger syndrome [5 cm(2) (3-6 cm(2)), -1.0 cm (-5.5 - 2.0 cm)] group had larger right atrium area and smaller left ventricular end-diastolic diameter than patients in mild group [1 cm(2) (-1 - 4 cm(2)), 3.0 cm (1.0-6.0 cm)], the differences were statistically significant (all P<0.05). (3) Each group's SPAP/brachial arterial-systolic (BSAP) pressure continously increased during gestation. The SPAP/BSAP only decreased in patients in mild or moderate group after termination. However, the SPAP/BSAP kept rising in patients in severe group or Eisenmenger syndrome group. (4) CHD-PAH patients in severe or Eisenmenger syndrome group had worse cardiac function, in which the rates of Ⅲ-Ⅳ cardiac function were 61%(14/23) and 12/17, compared with patients in mild [8% (2/26)] and moderate [12%(4/33)] group, the differences were statistically significant (all P<0.05). (5) The rates of medicine treatment, cesarean section were higher, the weeks of gestational termination were earlier and the newborn's weights were lower in patients in severe or Eisenmenger syndrome group, the differences were statistically significant (all P<0.05). Conclusions: (1) SPAP keeps rising during gestation in all patients with CHD-PAH, and the SPAP decreases after termination but it's still higher than the early pregnancy's SPAP. This suggests that pregnancy would exacerbate these patients' heart problems, the risk should be fully considered before and during pregnancy. (2) Patients with severe CHD-PAH or combined with Eisenmenger syndrome have lager right atrium area, smaller left ventricular end-diastolic diameter, worse cardiac function, and bigger changes of hemodynamic, the incidence of adverse outcomes of mothers and children is also high, pregnancy should be avoided.


Assuntos
Cesárea , Hemodinâmica/fisiologia , Hipertensão Pulmonar , Resultado da Gravidez , Criança , Feminino , Humanos , Recém-Nascido , Gravidez , Estudos Prospectivos
13.
Wiad Lek ; 72(7): 1380-1386, 2019.
Artigo em Polonês | MEDLINE | ID: mdl-31398173

RESUMO

Spina bifida (myelomeningocele) is the most prevalent developmental defect of the nervous system. In different regions of the world it affects from 0.3 to 5 per 1000 of living neonates. It is known that the defect develops during the early fetal life however no explicit cause has been found yet. Recently it has been accepted that one of the major factors contributing to spina bifida is deficiency of folic acid in the mother's body before and during pregnancy. The first attempts to cure myelomeningocele were taken in ancient times. More extensive knowledge of aetiology and effects of spina bifida and development of new surgical techniques allowed for management not only of the defect itself but also the consequent complications. Prenatal spina bifida repair has been performed in the USA for 20 years now while European surgeons (Poland and Switzerland) have operated myelomeningocele for 12 years. Comparative analysis carried out to evaluate the patients operated for spina bifida prenatally and postnatally pointed that those after fetal repair demand the use of ventriculoperitoneal shunt for hydrocephalus twice less frequently. Thanks to shortened exposure of the spinal cord and the spinal nerves to the toxic effect of amniotic fluid and reduced exposure to mechanical injuries, prenatal myelomeningocele repair offers better opportunities to improve motor, urinary and alimentary functions, contributing then statistically to higher quality of lives of children with spina bifida.


Assuntos
Hidrocefalia , Meningomielocele , Disrafismo Espinal , Feminino , Humanos , Recém-Nascido , Polônia , Gravidez , Qualidade de Vida
14.
Wiad Lek ; 72(7): 1408-1412, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31398177

RESUMO

Congenital thrombosis and amputation in infancy is not common. Therefore, the existing literature lacks sufficient evidence regarding this subject. Available research primarily focuses on treatment and causes of thrombosis in children. The paper describes a case of preterm infant after transtibial amputation due to common iliac artery thrombosis during the perinatal period. The girl began neurodevelopmental therapy based on normal development patterns of infants, which was provided three times a week for 45 minutes. The rehabilitation process also included prosthesis and surgical interventions. The assessment of motor development of the child was carried out at the age of 6, 9, 12, 18 and 20 months, using the motor scale of the Albert Infants Motor Scale (AIMS). Case analysis allows to state that infant rehabilitation after transtibial amputation should be individualized, and focus on supporting normal motor development, based on the correct movement sequences of infants. Additionally, the AIMS scale can be used to assess the gross motor development in infants after amputation and is useful in formulating early therapeutic intervention. A prosthetist should perform prosthesis revisions as often as needed, i.e., in infants that is usually every 4 months. What is more, successful outcomes can be achieved by implementing proper surgical procedures regarding the appositional overgrowth of the residual limb in growing children.


Assuntos
Membros Artificiais , Doenças do Prematuro , Trombose , Amputação , Feminino , Humanos , Lactente , Recém-Nascido , Recém-Nascido Prematuro , Trombose/complicações
18.
Medicine (Baltimore) ; 98(32): e15837, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31393341

RESUMO

Peripherally inserted central catheters (PICCs) can provide nutritional and medical support for very low birth weight or critically ill newborns. The aim of this study was to retrospectively analyze the use of PICCs in our clinic for critically ill newborns to evaluate the relationship between catheter related factors and the occurrence of complications.Retrospective analysis was conducted for all newborns consecutively admitted at the Neonatal Intensive Care Unit (NICU), Chongqing Health Center for Women and Children, who underwent PICC insertion between May 2011 and March 2018. Data collected included total puncture success rate, one puncture success rate, infection rate, complication rate, unplanned catheter withdrawal rate, device days, and catheter indwelling time.Five-hundred eighty-eight infants (304 males and 284 females) aged 3.4 ±â€Š3.9 days, mean gestational age of 30.9 ±â€Š2.7 weeks and a mean body mass of 1.38 ±â€Š0.47 kg at insertion were included. Total puncture success rate was 99.65%, one puncture success rate was 77.77%. The mean catheter retention was 13.6 ±â€Š6.7 days: more than 30 days in 15 (2.61%) cases, 20 to 30 days in 60 (10.43%) cases, 10 to 19 days in 372 (64.70%) cases, and 62 days in 1 case. Complications occurred in 63 (10.71%) cases: with PICC insertion within 24 hours after birth in 29 (15.43%), within 48 hours in 13 (6.63%), and after 48 hours in 21 (10.99%) cases. Catheter tip culture was positive in 3 cases and there was 1 case of catheter-related bloodstream infection.Nursing measures of the maintenance of body temperature and the evaluation of blood vessels were important conditions for improving the success rate of one puncture in critically ill neonates. PICC catheterization as early as 48 hours will not increase the difficulty of PICC puncture. Nor did it increase the incidence of PICC complications.


Assuntos
Cateterismo Periférico/estatística & dados numéricos , Cateteres de Demora/estatística & dados numéricos , Estado Terminal , Unidades de Terapia Intensiva Neonatal/estatística & dados numéricos , Infecções Relacionadas a Cateter/epidemiologia , Infecções Relacionadas a Cateter/prevenção & controle , Cateteres de Demora/efeitos adversos , Feminino , Idade Gestacional , Humanos , Recém-Nascido , Recém-Nascido de muito Baixo Peso , Masculino , Estudos Retrospectivos
19.
Medicine (Baltimore) ; 98(32): e16777, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31393401

RESUMO

OBJECTIVE: To analyze the clinical results of transanal endorectal pull-through (TERPT) and transabdominal approach (TAB) in the treatment of Hirschsprung disease. METHODS: We searched all publications in the PubMed, MEDLINE, EMBASE, and Cochrane library databases between January 2003 and November 2018. The study included randomized controlled trials (RCTs) and observational clinical studies (OCSs), to compare the surgery duration, length of postoperative hospital stay, incidence of postoperative incontinence/soiling, constipation, and enterocolitis between the TERPT and TAB groups. Mantel-Haenszel method was used for continuous variables, the combined odds ratios (ORs) and 95% confidence intervals (CIs) for dichotomous variables were used. RESULTS: In the 87 studies, we include 1 case of RCTs and 9 cases of OCSs. Including 392 cases of TERPT and 332 cases of TAB groups. TERPT has a short postoperative hospitalization [mean difference (MD) = -6.74 day; 95% CIs; -13.26 to -0.23; P = .04], and a low incidence of postoperative incontinence (ORs = 0.54; 95% CIs, 0.35-0.83; P = .006) and constipation (ORs = 0.50; 95% CIs, 0.28-0.90; P = .02). There was no difference in duration of surgery (MD = -30.59 min; 95% CIs, -98.01-36.83; P = .37) and incidence of postoperative enterocolitis (ORs = 0.78; 95% CIs, 0.53-1.17; P = .23). CONCLUSION: TERPT is superior to TAB in terms of hospitalization time, postoperative incontinence, and constipation. However, there are still a large number of RCTs to verify, and more trials are expected to be testified in the future.


Assuntos
Procedimentos Cirúrgicos do Sistema Digestório/métodos , Doença de Hirschsprung/cirurgia , Procedimentos Cirúrgicos Minimamente Invasivos/métodos , Complicações Pós-Operatórias/epidemiologia , Pré-Escolar , Constipação Intestinal/epidemiologia , Procedimentos Cirúrgicos do Sistema Digestório/efeitos adversos , Enterocolite/epidemiologia , Incontinência Fecal/epidemiologia , Humanos , Lactente , Recém-Nascido , Tempo de Internação , Procedimentos Cirúrgicos Minimamente Invasivos/efeitos adversos , Duração da Cirurgia
20.
Medicine (Baltimore) ; 98(33): e16840, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31415407

RESUMO

RATIONALE: Twin pregnancy in women with chronic kidney disease (CKD) is very rare but poses a great risk to both mother and children. In developing countries like China, advanced CKD twin pregnancies are often terminated. Here, we report a successful case and reviewed related cases, hope to facilitate further study. PATIENT CONCERNS: A 29-year-old woman with a twin pregnancy showed serum creatinine (Scr) 100 µmol/L (CKD2) at conception. During her 12th week, Scr reached 263 µmol/L (CKD4) with urine protein 3+ and hypertension. DIAGNOSES: Due to her pregnancy, renal biopsy was not considered. Lab tests showed deterioration of renal function and ultrasound detections showed small kidney size. INTERVENTIONS: The patient was given basic drug therapy to control her blood pressure and supplemental nutrition without hemodialysis. OUTCOMES: The patient delivered 2 healthy babies weighting 0.9 and 0.7 kg by cesarean section at the 28th week, but has been under maintenance hemodialysis since then. LESSONS: Despite low birth weight and preterm delivery, successful twin pregnancies in some patients with CKD could be realized under early multidisciplinary intervention, but this poses great risks for mothers and twins, especially for patients with advanced CKD and those on hemodialysis.


Assuntos
Complicações na Gravidez/fisiopatologia , Gravidez de Gêmeos , Insuficiência Renal Crônica/fisiopatologia , Adulto , Cesárea , China , Creatinina/sangue , Feminino , Glucocorticoides/uso terapêutico , Humanos , Recém-Nascido , Nifedipino/uso terapêutico , Prednisona/uso terapêutico , Gravidez , Complicações na Gravidez/sangue , Complicações na Gravidez/diagnóstico , Complicações na Gravidez/tratamento farmacológico , Insuficiência Renal Crônica/sangue , Insuficiência Renal Crônica/diagnóstico , Insuficiência Renal Crônica/tratamento farmacológico , Vasodilatadores/uso terapêutico
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