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1.
Artigo em Chinês | MEDLINE | ID: mdl-33541001

RESUMO

Objective:This study aimed to explore the differences in esophageal pressure at different ages, and to analyze the possible age inflection points of the physiological degeneration of esophageal motility, and to further evaluate whether the degeneration of esophageal kinetics with age is the only risk factor for the occurrence of throat reflux disease (LPRD). Methods:A solid-state high-resolution esophageal pressure measurement was performed on 41 volunteers without throat symptoms. The Chicago classification data were compared with the manometry results of all volunteers. In addition, the esophageal manometry results were compared among groups with pre-set age inflection point. Results:Most of the volunteers' esophageal pressure measurements were in line with Chicago standards. When the inflection point of age was 55 years, no significant difference was found between the two groups. However, when the inflection point of age was 65 years, a significant difference in the length of the upper esophageal sphincter and the contractile front velocity was found between the two groups(P=0.021 and 0.046 respectively). Conclusion:Esophageal dynamics was weakened with increasing age in the volunteers without laryngopharyngeal symptoms, which was more obvious after the age of 65, but still within the normal range. The degeneration of esophageal motility is not the only risk factor for LPRD.


Assuntos
Refluxo Laringofaríngeo , Idoso , Esfíncter Esofágico Superior , Humanos , Hipofaringe , Manometria , Pessoa de Meia-Idade , Voluntários
2.
Artigo em Chinês | MEDLINE | ID: mdl-33472303

RESUMO

Objective: To compare the clinical characteristics of patients with different type of laryngopharyngeal reflux disease in order to study the effect of non-acid reflux on laryngopharyngeal reflux disease. Methods: From January 2015 to January 2020, 349 inpatients or outpatients suspected of having laryngopharyngeal reflux underwent 24-hour multichannel intraluminal impedance pH monitoring (MII-pH). There were 303 male and 46 female patients, with an average age of 56.03 years old ranged from 25 to 81 years old. The reflux symptom index (RSI)and reflux findings score(RFS)were recorded before MII-pH monitoring. The number of acid reflux events and non-acid reflux events in hypopharynx were counted. It was defined mainly acid reflux type when the ratio of acid reflux to all reflux events was greater than 50%, mainly non-acid reflux type when the ratio of non-acid reflux to all reflux events was greater than 50%. The clinical characteristics of patients with different type of reflux were compared. SPSS 19.0 software was used for statistical analysis, and multiple independent samples were compared between groups. The quantitative data were analyzed by multivariate analysis of variance, and the counting data were analyzed by chi-square test, the difference was statistically significant when P<0.05. Results: The 24-hour MII-pH showed that there were 90 patients with no reflux events, 51 patients with mainly acid reflux type, 198 patients with mainly non-acid reflux type and 10 patients with equal acid reflux events and non-acid reflux events. Statistics showed that the RSI(10.72±4.40), RFS(7.70±2.73) and the average number of reflux events(0) in the group without reflux events were significantly lower than those in patients with mainly acid reflux type (RSI 13.16±6.62,RFS 10.08±3.03,average number of reflux events 5.33±3.15,P<0.05) and mainly non-acid reflux type(RSI 13.25±5.54,RFS 8.81±2.54,average number of reflux events 7.93±5.26, P<0.05). There was no significant difference in RSI between the mainly non-acid reflux type group and the mainly acid reflux type group, but the RFS of the mainly non-acid reflux type group was significantly lower than that of the mainly acid reflux type group. The average number of reflux events in the mainly non-acid reflux group was significantly higher than that in the mainly acid reflux type group (P<0.05). Conclusion: The results show that non-acid reflux plays a certain role in laryngopharyngeal reflux disease, but the effect of acid reflux is greater.


Assuntos
Refluxo Laringofaríngeo , Adulto , Idoso , Idoso de 80 Anos ou mais , Monitoramento do pH Esofágico , Feminino , Humanos , Hipofaringe , Refluxo Laringofaríngeo/diagnóstico , Refluxo Laringofaríngeo/epidemiologia , Masculino , Pessoa de Meia-Idade , Sistema Respiratório
5.
J Vis Exp ; (166)2020 12 14.
Artigo em Inglês | MEDLINE | ID: mdl-33369600

RESUMO

In addition to typical reflux symptoms, many patients with gastroesophageal reflux disease (GERD) present with extraesophageal symptoms such as cough, hoarseness or asthma, which can be caused by laryngopharyngeal reflux (LPR). Due to their multifactorial origin, those symptoms can be a great diagnostic and therapeutic challenge. Esophageal pH-monitoring is commonly used to determine abnormal esophageal acid exposure and confirm the diagnosis of GERD. However, for better evaluation of acid exposure above the upper esophageal sphincter, a new laryngopharyngeal pH measurement system is now available and may lead to more reliable results in patients with predominantly extraesophageal symptoms. This article aims to present a standardized protocol for simultaneous pH measurement using esophageal and laryngopharyngeal pH probes in order to obtain acid exposure scores from both measurements.


Assuntos
Monitoramento do pH Esofágico , Hipofaringe/fisiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Cateteres , Monitoramento do pH Esofágico/efeitos adversos , Feminino , Humanos , Refluxo Laringofaríngeo/diagnóstico , Refluxo Laringofaríngeo/etiologia , Refluxo Laringofaríngeo/terapia , Masculino , Pessoa de Meia-Idade , Reprodutibilidade dos Testes , Adulto Jovem
6.
Codas ; 32(5): e20180052, 2020.
Artigo em Português, Inglês | MEDLINE | ID: mdl-33174981

RESUMO

PURPOSE: To verify the association between laryngopharyngeal reflux (LPR) with age, gender, vocal deviation and voice complaints. METHODS: The study included patients between 18 and 70 years old, referred to the Otorhinolaryngology service for complaints of voice or reflux, of both sexes. Endolaryngeal findings were classified using the Reflux Finding Score (RFS) scale. The presence or absence of vocal and reflux complaints was verified and correlated with the RFS classification. On the same date, they were submitted to sustained vowel voice recording and chained speech. The auditory-perceptual assessment was performed by a speech therapist, classifying the general degree of vocal deviation based on the GRBASI scale. RESULTS: Ninety-seven patients were evaluated, with a mean age of 42. 6 years, 62. 3% female, and mean RFS scores of 6. 26 points. Among the patients, 48 subjects had vocal complaints, 34 women with a mean age of 44. 9 years and an average RFS score of 6. 94 points. The other 49 individuals had no vocal complaints, and of these 27 were women, with a mean age of 41. 2 years and a mean RFS score of 5. 5 points. The variables "reflux complaint", "vocal complaint" and age were the ones that most correlated with the RFS scale scores. CONCLUSION: There is a relationship among reflux complaints, laryngeal findings and vocal complaint.


Assuntos
Refluxo Laringofaríngeo , Voz , Adolescente , Adulto , Idoso , Feminino , Humanos , Refluxo Laringofaríngeo/complicações , Refluxo Laringofaríngeo/diagnóstico , Masculino , Pessoa de Meia-Idade , Qualidade da Voz , Adulto Jovem
8.
Bull Environ Contam Toxicol ; 105(5): 685-691, 2020 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-33067667

RESUMO

Owls are predators that perform important ecological functions. There are several threats to owl conservation such as the bioaccumulation of chemicals through environmental contamination. The high probability of bioaccumulation in these animals is related to their role as predators and high trophic positions. The objective of this study was to quantify four elements (cadmium, chromium, nickel, and lead) as the biomarkers of environmental exposure in owls. To this end, we analyzed pellets and feathers of different owl species. These matrices were contaminated with all four elements, with chromium most commonly detected. Chromium and nickel were found in the pellets in all 10 months of the study, and May was the month with the highest concentrations of all the elements. Tyto furcata appears to bioaccumulate more elements in its feathers than Megascops spp. and Athene cunicularia. Our findings showed bioaccumulation of these four elements in owls and their environment.


Assuntos
Monitoramento Biológico/métodos , Poluição Ambiental/análise , Plumas/química , Conteúdo Gastrointestinal/química , Metais Pesados/análise , Estrigiformes/crescimento & desenvolvimento , Animais , Cádmio/análise , Cromo/análise , Refluxo Laringofaríngeo , Chumbo/análise , Metais Pesados/metabolismo , Níquel/análise
12.
Medicine (Baltimore) ; 99(34): e21791, 2020 Aug 21.
Artigo em Inglês | MEDLINE | ID: mdl-32846811

RESUMO

The current barrier for investigation of Barrett esophagus (BE) in Asia is diagnostic standardization, which is a challenge to identify its true risk factors. This study aimed to investigate the prevalence, clinical characteristics and risk factors of BE in Vietnamese patients with upper gastrointestinal symptoms.A cross-sectional study was conducted on consecutive outpatients who underwent upper gastrointestinal endoscopy. Endoscopically suspected esophageal metaplasia (ESEM) which was clearly visible at least 1 cm above the gastroesophageal junction at endoscopy was taken biopsy. At least 1 biopsy per 2 cm in tongues of ESEM and 4 biopsies per 2 cm of circumferential ESEM were taken. The diagnostic criterion for BE was replacement of the normal squamous epithelial lining by columnar epithelium confirmed by histology.A total of 1947 patients were recruited. Forty-seven out of 58 patients with ESEM were histologically confirmed BE. The prevalences of BE and hiatal hernia (HH) were 2.4% (95% confidence interval [CI], 1.7-3.1%) and 2.3% (95% CI, 1.6-2.9%), respectively. Heartburn and/or regurgitation presented in only 61.7% (95% CI, 46.4-75.5%) of patients with BE. In multivariate analysis, the only 2 factors significantly associated with BE were HH (OR 7.53; 95% CI, 3.13-18.11; P < .001) and typical reflux symptom (OR 2.07; 95% CI, 1.12-3.83; P = .020).BE is not uncommon in Vietnamese patients with upper gastrointestinal symptoms. In addition, typical reflux symptoms and HH are the risk factors for BE in Vietnamese.


Assuntos
Esôfago de Barrett/epidemiologia , Esôfago de Barrett/patologia , Esôfago/patologia , Adulto , Esôfago de Barrett/diagnóstico por imagem , Biópsia , Estudos Transversais , Endoscopia Gastrointestinal , Feminino , Azia/epidemiologia , Hérnia Hiatal/epidemiologia , Humanos , Refluxo Laringofaríngeo/epidemiologia , Masculino , Metaplasia/diagnóstico por imagem , Metaplasia/patologia , Pessoa de Meia-Idade , Prevalência , Estudos Prospectivos , Fatores de Risco , Avaliação de Sintomas , Vietnã/epidemiologia
13.
Artigo em Chinês | MEDLINE | ID: mdl-32842185

RESUMO

Objective:To study the clinical characteristics and common etiology of vocal cord leukoplakia, and explore the treatment principle. Method:One hundred and fifty-seven patients with vocal cord leukoplakia were recruited in this study. They were assessed by routine laryngoscope, narrow band imaging (NBI), stroboscope, reflux finding score (RFs) and reflux symptom index (RSI), and given conservative treatment (smoking cessation, alcohol, acid suppression, sound cessation, etc.) and/or surgical treatment. Result:Among 157 patients with leukoplakia of vocal cord, 109 (69.4%) had basically improved or cured after conservative treatment. Forty-eight cases underwent operation. The postoperative pathological diagnosis was mild dysplasia in 2 cases (1.3%), moderate dysplasia in 15 cases (9.6%), severe dysplasia or carcinoma in situ in 19 cases (12.1%), and invasive carcinoma in 12 cases (7.6%). Conclusion:NBI and stroboscopic laryngoscopy showed that most of the leukoplakia of vocal cord was non-malignant in nature, which was not in accordance with the indication of operation. Conservative treatment is effective. Biopsy or operation was indicated in only a few patients. Moreover, most of the patients are accompanied by laryngopharyngeal reflux, and the treatment of acid suppression is effective.


Assuntos
Doenças da Laringe , Refluxo Laringofaríngeo/cirurgia , Humanos , Laringoscopia , Leucoplasia , Imagem de Banda Estreita , Prega Vocal
14.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi ; 34(8): 710-712;718, 2020 Aug.
Artigo em Chinês | MEDLINE | ID: mdl-32842203

RESUMO

Objective:To investigate the clinical effect of proton pump inhibitor combined with ranitidine on patients with laryngopharyngeal reflux. Method:Seventy patients with laryngopharyngeal reflux diagnosed in our hospital were randomly divided into group A and group B according to admission time. The difference of B symptom index, reflux symptom scale, sleep breathing test, quality of life and well-being score between the two groups were detected. Result:Before treatment, the RSI index, RFS similarity and QOLS and MUNSH scores were similar (P>0.05). After four weeks of treatment, the group B score was 3.3±1.2, the group A score was 8.2±3.5, and the group B score was significantly lower. The RFS score of group A (6.2±2.3) was higher than that of group B (2.1±1.9, P<0.05). The scores of QOLS and MUNSH in group B were (67.57±7.26) and (23.99±3.44), respectively. The scores of QOLS and MUNSH in group A (50.13±10.19) and (12.21±1.47), respectively. The results of the two groups were significantly different (P<0.05). After treatment, the RSI index, RFS score, QOLS and MUNSH scores of the two groups were lower than those before treatment. (P<0.05). As for the sleep respiration monitoring (PSG) results, after 4-week treatment, compared with the group A, the total sleep time of the group B was significantly increased (P<0.05), and the number of wakefulness and wakefulness was significantly decreased. The duration of Ⅲ+Ⅳ sleep was also significantly increased, and the proportion of REM sleep time and AHI was significantly reduced (P<0.05). Conclusion:Proton pump inhibitor combined with ranitidine is more effective and safer than single drug treatment, and can significantly improve the throat reflux symptoms.


Assuntos
Refluxo Laringofaríngeo , Inibidores da Bomba de Prótons , Humanos , Faringe , Estudos Prospectivos , Qualidade de Vida , Ranitidina , Resultado do Tratamento
15.
Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi ; 34(4): 343-345;350, 2020 Apr.
Artigo em Chinês | MEDLINE | ID: mdl-32842230

RESUMO

Objective:To compare the consistency of RSI and RFS, pepsin detection and 24 h Dx-pH monitoring in the diagnosis of laryngopharyngeal reflux (LPR) in children. Method:A retrospective analysis was made of 76 children with suspicious LPR. A total of 65 children with suspicious LPR were finally diagnosed. RSI and RFS scales, pepsin detection and Dx-pH monitoring were performed simultaneously. The diagnostic consistency of the three methods was tested, and the sensitivity and specificity were calculated. Result:The sensitivity of pepsin detection, 24 h Dx-pH monitoring, RSI and RFS in the diagnosis of LPR in 76 suspected LPR patients were 95.31%, 66.15% and 84.62%, and the specificity were 100%, 81.82% and 72.73%. The pepsin detection was well consistent with the scale(Kappa>0.75), pepsin detection and 24 h Dx-pH monitoring were in medium consistency(Kappa=0.467), and 24 h Dx-pH monitoring and scale were in medium consistency(Kappa=0.446). Conclusion:Pepsin detection can be used as a reliable index for the diagnosis of LPR in children. It is objective, economical, non-invasive, comfortable and easy to spread.


Assuntos
Refluxo Laringofaríngeo , Criança , Monitoramento do pH Esofágico , Humanos , Pepsina A , Estudos Retrospectivos , Sensibilidade e Especificidade
16.
Artigo em Chinês | MEDLINE | ID: mdl-32842234

RESUMO

Objective:To investigate the clinical characteristics, diagnosis and treatment of female laryngeal contact granuloma. Method:The clinical data of 46 female patients with laryngeal contact granuloma diagnosed and treated by our clinical team from March 2011 to October 2018 were retrospectively analyzed. Result:The age of the 46 patients ranged from 5 to 58 years old, with an average age of 36.76 years old. The causes of the contact granulomas historically may be the result of intubation in 33 cases, laryngopharyngeal reflux in 8 cases, chronic cough in 2 cases, laryngopharyngeal reflux combined with chronic cough in 2 cases, and voice abuse and excessive clearing of the throat in one case. All patients were followed up for at least half a year, and all of them were cured. Among the 6 patients with large lesions who underwent surgical treatment, 3 relapsed within 3 months, PPI treatment was performed for 2 to 6 months after recurrence, and no recurrence was observed during follow-up, with an average course of treatment of (1.67±2.34) months. All the 11 patients who received corticosteroid injections recovered after 1 to 7 injections, with a median of 3 injections, and an average course of treatment of (2.64±1.69) months. All the 13 patients with oral PPI were cured, with an average course of treatment of (4.15±2.76 )months; No recurrence was found in the follow-up of 16 patients with conservative treatment under regular observation, with an average course of treatment of (5.88±3.76) months. The difference in cure time between the intervention group (30 cases) and the observation group (16 cases) was statistically significant, and the cure time of the intervention group was shorter than that of the observation group (H=11.902, P=0.008). Conclusion:Female patients with laryngeal contact granuloma are common after intubation, and various treatments or conservative observation can achieve good results, and treatment intervention may shorten the cure time.


Assuntos
Granuloma Laríngeo , Refluxo Laringofaríngeo , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Granuloma , Humanos , Pessoa de Meia-Idade , Recidiva , Estudos Retrospectivos , Adulto Jovem
17.
Artigo em Chinês | MEDLINE | ID: mdl-32791777

RESUMO

Objective: To investigate whether laryngopharyngeal reflux(LPR) is an independent risk factor for vocal fold polyps and to analyze the potential mechanism. Methods: Case control survey was designed. Subjects who came to the Department of Otorhinolaryngology Head and Neck Surgery of the First Affiliated Hospital of Chongqing Medical University from September 2018 to December 2019, including 152 cases with vocal fold polyps and 176 cases with normal vocal folds, were selected. All the subjects filled in a questionnaire and were assessed by the reflux symptom index (RSI) and the reflux finding score (RFS) scale. RSI>13 and(or) RFS>7 were classified as LPR. Chi-square test, univariate and multivariate unconditional logistic regression models were used for statistical analysis. Results: The incidence of LPR and throat clearing in vocal fold polyps group (47.37%, 73.68%) was significantly higher than that in control group (27.27%, 59.09%), with statistically significant difference (P<0.001, P=0.005, respectively). The incidence of troublesome cough, indigestion or stomach acid coming up was no difference between the two groups(P=0.672, P=0.099). Multivariate unconditional logistic regression analysis showed that LPR (OR=1.815, 95%CI:1.061-3.103), occupational exposure(OR=2.655, 95%CI:1.397-5.042), spicy food(OR=1.958, 95%CI:1.142-3.355) were risk factors for vocal fold polyps. Conclusion: LPR, occupational exposure, spicy food are independent risk factors for vocal fold polyps. Frequent throat clearing caused by LPR may be the main cause of vocal ford polyps. In order to prevent vocal fold polyps, we need to take action to treat laryngopharyngeal reflux disease actively.


Assuntos
Doenças da Laringe , Refluxo Laringofaríngeo , Pólipos , Prega Vocal/patologia , Estudos de Casos e Controles , Humanos , Doenças da Laringe/etiologia , Doenças da Laringe/patologia , Refluxo Laringofaríngeo/complicações , Pólipos/patologia , Fatores de Risco , Inquéritos e Questionários
18.
J Laryngol Otol ; 134(8): 684-687, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32758307

RESUMO

BACKGROUND: The coronavirus disease 2019 pandemic has necessitated almost exclusive National Health Service focus on emergency work and cancer care. There are concerns that increased hospital and community pressures will lead to decreased referrals and worse outcomes for head and neck cancer patients. METHOD: This is a retrospective review of all cases referred for suspected head and neck cancer to our institution in January and April 2020. RESULTS: There was a 55 per cent decrease in referrals but diagnostic yield rose from 2.9 per cent in January to 8.06 per cent in April. In both months, 100 per cent of patients met the 31- and 62-day targets, with similar 14-day wait time success (97.83 per cent for January vs 98.33 per cent for April). Referrals for laryngopharyngeal reflux rose from 27.5 per cent to 41.9 per cent. Referrals for those aged over 60 years fell from 42 per cent to 26 per cent. CONCLUSION: It is suggested that further research be conducted into the reasons why fewer patients were referred, particularly elderly patients, and why laryngopharyngeal reflux is so prevalent in fast-track referrals.


Assuntos
Infecções por Coronavirus/transmissão , Neoplasias de Cabeça e Pescoço/diagnóstico por imagem , Refluxo Laringofaríngeo/epidemiologia , Pneumonia Viral/transmissão , Encaminhamento e Consulta/estatística & dados numéricos , Idoso , Idoso de 80 Anos ou mais , Betacoronavirus/isolamento & purificação , Estudos de Casos e Controles , Infecções por Coronavirus/epidemiologia , Infecções por Coronavirus/virologia , Feminino , Neoplasias de Cabeça e Pescoço/epidemiologia , Humanos , Refluxo Laringofaríngeo/diagnóstico , Imagem por Ressonância Magnética/métodos , Masculino , Pessoa de Meia-Idade , Pandemias , Pneumonia Viral/epidemiologia , Pneumonia Viral/virologia , Prevalência , Estudos Retrospectivos , Medicina Estatal/organização & administração , Centros de Atenção Terciária/estatística & dados numéricos , Ultrassonografia/métodos , Reino Unido/epidemiologia
19.
PLoS One ; 15(8): e0237581, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32797062

RESUMO

OBJECTIVES: To investigate the role of gastroesophageal reflux disease (GERD) and laryngopharyngeal reflux (LPR) in the development of dental disorders. METHODS: The first outcome was review of the role of reflux in the development of dental disorders in adults. The second outcome was review of the potential pathophysiological mechanisms underlying the association between reflux and dental disorders. Three investigators screened publications for eligibility and exclusion based on predetermined criteria through a literature search conducted on PubMed, Cochrane Library, and Scopus according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). RESULTS: From 386 publications, 24 studies were kept for analysis. Objective approaches were used in 16 studies to confirm GERD diagnosis. Pharyngeal reflux episodes (LPR) were considered in 2 studies. No study considered nonacid reflux. The study results supported a higher prevalence of dental erosion and caries in reflux patients compared with healthy individuals. Patients with dental erosion have a higher prevalence of reflux than controls. The pathophysiological mechanisms would involve changes in the saliva physiology. No study investigated the microbiota modifications related to reflux although the findings are supporting the critical role of microbiota change in the development of dental disorders. There is an important heterogeneity between studies about diagnostic methods and clinical outcome evaluation. CONCLUSION: The involvement of reflux in the development of dental disorders is not formally demonstrated and requires future investigations considering pharyngeal acid and nonacid reflux episodes and in particular their potential impact on oral microbiota.


Assuntos
Cárie Dentária/epidemiologia , Esofagite Péptica/epidemiologia , Refluxo Laringofaríngeo/epidemiologia , Humanos , Prevalência , Fatores de Risco , Saliva/química
20.
Artigo em Chinês | MEDLINE | ID: mdl-32791597

RESUMO

Objective:To investigate the relationship between laryngopharyngeal reflux and arytenoid cartilage calcification in male idiopathic laryngeal contact granuloma. Method:The clinical data of 92 male patients with idiopathic laryngeal contact granuloma who had the thin laryngeal CT scan images and laryngeal reflux symptom index(RSI) scale data before treatment were analyzed retrospectively. The effect of laryngopharyngeal reflux on the calcification of arytenoid cartilage in laryngeal contact granuloma patients was analyzed by Chi-square statistics with SPSS 16.0 software. Result:Among the 92 patients, 44 patients with RSI>13(47.83%) and 48 patients with RSI≤13(52.17%). Unilateral granuloma was found in 87 cases(94.57%) and bilateral granuloma in 5 cases(5.43%). A total of 97 sides of the diseased side, there were 87 sides of arytenoid cartilage with calcification(89.69%) and 10 sides without calcification(10.31%). Among the patients with RSI>13, there were 45 sides of arytenoid cartilage with calcification(45/46, 97.83%) and one side without calcification(1/46, 2.17%), and in the patients with RSI≤13, there were 42 sides of arytenoid cartilage with calcification(42/51, 82.35%) and 9 sides without calcification(9/51, 17.65%). The calcification rate of arytenoid cartilage in patients with RSI>13 group was significantly higher than that in RSI≤13 group(χ²=4.701, P=0.030). Conclusion:The calcification rate of arytenoid cartilage in male idiopathic laryngeal contact granuloma patients with laryngopharyngeal reflux is higher than that in patients without laryngopharyngeal reflux. Laryngopharyngeal reflux may aggravate or promote the inflammatory reaction of granuloma and accelerate the calcification of arytenoid cartilage.


Assuntos
Granuloma Laríngeo , Refluxo Laringofaríngeo , Cartilagem Aritenoide , Granuloma , Humanos , Masculino , Estudos Retrospectivos
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