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1.
Medicine (Baltimore) ; 98(44): e17736, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31689819

RESUMO

To explore associated risk factors and their interactions with type 2 diabetes (T2DM) among the elderly with prediabetes in rural areas in China.A nested case-control study was conducted in a fixed cohort to identify the risk factors for T2DM among the elderly with prediabetes in rural areas of Yiyang City in China. A total of 37 elderly with T2DM were included in the cases group and 111 elderly subjects with prediabetes were matched in the control group. Data related to sociodemographic characteristics, lifestyle behavior, and anthropometric variables were collected by trained staff using standard tools. The risk factors for T2DM were determined using conditional logistic regression analysis, and their additive interactions were also explored.Multivariable conditional logistic regression analysis results showed that overweight/obesity (odds ratio [OR] = 4.80, 95% confidence interval [CI]: 1.20-12.28), family history of diabetes (OR = 3.63, 95% CI: 1.03-12.81), physically inactive (OR = 3.08, 95% CI: 1.14-8.30), high waist-to-hip ratio (WHR) (OR = 3.15, 95% CI: 1.27-7.80), and inadequate diabetes-specific health literacy (DSHL) (OR = 3.92, 95% CI: 1.14-13.48) increased the risk for T2DM. Additive interactions for T2DM were observed between a family history of diabetes and high WHR with a relative excess risk of interaction (RERI) of 10.02 (95% CI: 4.25, 15.78), and between high WHR and overweight or obesity, with an RERI of 3.90 (95% CI: 0.36, 7.44).The independent risk factors for T2DM are overweight or obesity, high WHR, family history of diabetes, physically inactive, and inadequate DSHL. High WHR as a risk factor for T2DM has additive interactions with family history of diabetes and overweight or obesity.


Assuntos
Diabetes Mellitus Tipo 2/etiologia , Estado Pré-Diabético/etiologia , População Rural/estatística & dados numéricos , Idoso , Antropometria , Estudos de Casos e Controles , China/epidemiologia , Diabetes Mellitus Tipo 2/epidemiologia , Diabetes Mellitus Tipo 2/fisiopatologia , Exercício , Feminino , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Estado Pré-Diabético/epidemiologia , Estado Pré-Diabético/fisiopatologia , Risco , Fatores de Risco , Comportamento Sedentário , Relação Cintura-Quadril
2.
Medicine (Baltimore) ; 98(39): e16788, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31574794

RESUMO

BACKGROUND: The aim of this study was to observe the effect and safety of Heyan Kuntai Capsule (HYKT) on glucose and lipid metabolism in patients with polycystic ovary syndrome (PCOS). METHODS: Hundred patients with PCOS were randomly divided into HYKT group (n = 50) and placebo groups (n = 50) in which the individuals were treated with HYKT and its placebo continuously for 6 months. Meanwhile, all participants received health education (such as exercise and diet). The primary outcomes were serum sex hormone levels, a series of blood lipid, fasting and postprandial 2 hours blood glucose. Body mass index (BMI), waist-hip ratio (WHR), insulin, homeostatic model assessment of insulin resistance (HOMA-IR), and insulin-sensitive index (ISI) were also observed. In addition, adverse events were recorded to evaluate the drug safety. RESULTS: After treatment, the BMI and WHR of all the patients were decreased. The fasting and postprandial 2 hours blood glucose levels were significantly declined when treated with HYKT, which were not observed in the placebo group. Similarly, serum sex hormones including luteinizing hormone (LH), LH/follicle-stimulating hormone (FSH), and testosterone were lowered after treated with HYKT instead of the placebo. Besides, blood lipids outcomes such as total cholesterol, triglyceride, and low-density lipoprotein cholesterol, as well as insulin and HOMA-IR were decreased with significance in HYKT group when compared with those in the placebo group, whereas high-density lipoprotein cholesterol and ISI increased obviously. CONCLUSION: HYKT showed the effect on ameliorating the glucose and lipid metabolism disorder and improving insulin resistance and increase insulin sensitivity of PCOS patients, which is similar to insulin sensitizing agent.


Assuntos
Glicemia/metabolismo , Medicamentos de Ervas Chinesas/efeitos adversos , Medicamentos de Ervas Chinesas/uso terapêutico , Lipídeos/sangue , Síndrome do Ovário Policístico/sangue , Síndrome do Ovário Policístico/tratamento farmacológico , Adolescente , Adulto , Índice de Massa Corporal , Método Duplo-Cego , Estradiol/sangue , Feminino , Hormônio Foliculoestimulante/sangue , Humanos , Insulina/sangue , Resistência à Insulina , Hormônio Luteinizante/sangue , Prolactina/sangue , Testosterona/sangue , Relação Cintura-Quadril , Adulto Jovem
3.
Zhongguo Dang Dai Er Ke Za Zhi ; 21(9): 910-914, 2019 Sep.
Artigo em Chinês | MEDLINE | ID: mdl-31506152

RESUMO

OBJECTIVE: To study the relationship between serum microRNA-122 (miR-122) and insulin resistance in obese children. METHODS: Forty-seven children with severely obesity aged 7-14 years and 45 age- and gender matched healthy children with normal weight (control group) were enrolled. The levels of height, weight, waistline, hip circumference, fasting blood glucose (FBG), fasting insulin (FINS), triglyceride (TG), total cholesterol (TC), free fatty acid (FFA), interleukin-6 (IL-6) and miR-122 in the two groups were measured. Body mass index (BMI), waist-hip ratio (WHR) and insulin resistance index (HOMA-IR) were calculated. RESULTS: Compared with the control group, the height, weight, BMI, WHR, FINS, HOMA-IR, TG, FFA, IL-6, and miR-122 levels in the obese group were significantly increased (P<0.05). MiR-122 levels in the obese group were positively correlated with FINS, HOMA-IR and IL-6 levels (r=0.408, 0.442, and 0.464 respectively, P<0.05). The changes of miR-122 have a linear regression relationship with IL-6 (b'=0.318, P<0.05). CONCLUSIONS: The elevated serum miR-122 levels may be correlated with insulin resistance in obese children. The mechanism needs to be further studied.


Assuntos
Resistência à Insulina , MicroRNAs/genética , Adolescente , Glicemia , Índice de Massa Corporal , Criança , Humanos , Insulina , Obesidade , Relação Cintura-Quadril
4.
Adv Exp Med Biol ; 1193: 135-154, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31368102

RESUMO

Obesity is multifactorial and complex. Remarkable progress has been made recently in search for polygenic obesity through genome-wide association study (GWAS), but biology of polygenic effects on obesity is largely poor. This review summarizes the available evidence and provides an overview of the links between ALDH2 variants and adiposity, which were firstly and mainly derived from studies of polygenic obesity and also indirectly investigated by using cell lines and mice. The genetic association studies have observed consistent associations of ALDH2 variants with obesity-related traits including BMI, waist circumference (WC), waist-to-hip ratio (WHR), and visceral fat accumulation. In consideration of ALDH2 variants with enzyme activity and alcohol consumption behavior in physiological mechanism studies, we proposed a model by which the physiological and behavioral consequences of alcohol consumption serve as an intermediary process between polymorphisms in ALDH2 and obesity.


Assuntos
Aldeído-Desidrogenase Mitocondrial/genética , Obesidade/genética , Adiposidade/genética , Animais , Índice de Massa Corporal , Estudo de Associação Genômica Ampla , Humanos , Camundongos , Polimorfismo de Nucleotídeo Único , Circunferência da Cintura , Relação Cintura-Quadril
5.
Georgian Med News ; (290): 89-96, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31322522

RESUMO

The aim of the research was standard and alternative measurement of anthropometric indices in Georgian healthy elderly population for determining the reliability/validity of the widely used and recognized assessment tools. Our research is the first study of the anthropometry as the part of of nutritional status assessment in Georgian elderly. For anthropometric assessment we first time used 1. Standard measurements (weight, height, WC, HC, MAC /MUAC, TSF, BMI, WHR, AMA using standard methods and tools for measurable values and standard formulas for calculating values), and 2. Alternative measurements (demispan, demispan equivalent height and BMI (DEH, DE BMI), Mindex for women, Demiquet for men. using Bassey's equations). Our study group formed for the nutritional status assessment in Georgian healthy elderly (Study group ≥ 60 y (n=75): men (n=14); women (n=61). Subgroup <75 y (n=64): men (n=9); women (n=55); Subgroup 75+ y (n=11); men (n=5); women (n=6)). Based on BMI range, the data from 78.7% of participants' were above the norm, 21.3% - normal and 0 - below the norm. The findings of our study have shown that BMI is not height-dependent variable, moreover, BMI as mindex and demiquet is a mass/weight-dependent anthropometric characteristic. BMI, demiquet and mindex had nearly same correlation with other anthropometric parameters (especially for women). High correlation between direct measured/calculated BMI and DE BMI were confirmed by Pearson coefficient 0.979 (p<0.01). The Cohen's Unweighted Kappa index was 0.8518 (0.81 - 1.00 almost perfect or perfect agreement). According to the Paired Samples Test results, there were no difference between BMI and DE BMI. Statistically significant difference between the BMI and DE BMI was determined only for men (0.003 - difference is significant at p<0.05). However, there were only 14 men in our research group and the use of this method recommended in a larger group. Graphical Bland and Altman agreement analysis demonstrated the absence of the trends in differences between BMI and DE BMI. The findings of our research confirm that Demi-span is a reliable measure of stature in Georgian healthy elderly. Demiquet and Mindex are useful indices for our population and suitable for use in clinical practice and in the study of the Georgian elderly when the use of standard weight to height indices may be questionable. Considering to results of statistical analysis, strength of correlation and agreement between direct measured BMI and alternative BMI confirms that the Bassey's equation is valid for Georgian healthy elderly, Demispan equivalent height and BMI is reliable and, accordingly, useful in case of lack of standard calculations or to avoid errors of direct measurements. However, further studies with higher subject numbers are needed to confirm our findings. Additional studies covering other communities in Georgia with different socioeconomic and ethnic composition, also, with different diseases would be necessary to obtain a better anthropometric characterization of the Georgian elderly.


Assuntos
Antropometria , Braço/anatomia & histologia , Estatura , Índice de Massa Corporal , Avaliação Geriátrica/métodos , Idoso , Idoso de 80 Anos ou mais , Antropometria/métodos , Estudos Transversais , Feminino , Georgia , Voluntários Saudáveis , Humanos , Masculino , Estado Nutricional , Valores de Referência , Reprodutibilidade dos Testes , Pregas Cutâneas , Circunferência da Cintura , Relação Cintura-Quadril
6.
BMC Public Health ; 19(1): 700, 2019 Jun 06.
Artigo em Inglês | MEDLINE | ID: mdl-31170949

RESUMO

BACKGROUND: Little is known about the long-term shifts in distributions of three abdominal-obesity-related indicators, waist circumference (WC), waist-to-hip ratio (WHpR) and waist-to-height ratio (WHtR) among Chinese adults. Traditional mean regression models used in the previous analyses were limited in their ability to capture cross-distribution among effects. The current study aims to describe the shift in distribution of WC, WHpR, and WHtR over a period of 18 years (1993-2011) in China, and to reveal quantile-specific associations of the three indicators with key covariates. METHODS: Longitudinal data from seven waves of the China Health and Nutrition Surveys (CHNS) in 1993, 1997, 2000, 2004, 2006, 2009 and 2011 were analyzed. The LMS method was used to illustrate the gender-specific quantile curves of WC, WHtR and WHpR over age. Separate gender-stratified longitudinal quantile regressions were employed to investigate the effect of important factors on the trends of the three indicators. RESULTS: A total of 11,923 participants aged 18-65 years with 49,507 observations were included in the analysis. The density curves of WC, WHtR and WHpR shifted to right and became wider. The three outcomes all increased with age and increased more at upper percentiles. From the multivariate quantile regression, physical activity was negatively associated in both genders; smoking only had a negative effect on male indicators. Education and drinking behavior both had opposite effects on the three indicators between men and women. Marital status and income were positively associated with the shifts in WC, WHtR and WHpR in male and female WC, while urbanicity index had a positive effect on three outcomes in men but inconsistent effect among female outcomes. CONCLUSIONS: The abdominal-obesity related indicators of the Chinese adults experienced rapid growth according to our population-based, age- and gender-specific analyses. Over the 18-year study period, major increases in WC, WHtR and WHpR were observed among Chinese adults. Specifically, these increases were greater at upper percentiles and in men. Age, physical activity, energy intake, drinking, smoking, education, income and urbanicity index were associated with elevated abdominal obesity indicators, and the effects differed among percentiles and between genders.


Assuntos
Grupo com Ancestrais do Continente Asiático/estatística & dados numéricos , Obesidade/epidemiologia , Circunferência da Cintura , Razão Cintura-Estatura , Relação Cintura-Quadril , Adolescente , Adulto , Idoso , Índice de Massa Corporal , China/epidemiologia , Ingestão de Energia , Exercício , Feminino , Humanos , Renda , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Inquéritos Nutricionais , Obesidade Abdominal/epidemiologia , Análise de Regressão , Adulto Jovem
7.
J Dermatol ; 46(8): 695-701, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31149744

RESUMO

Psoriasis is a chronic inflammatory skin disease known to be associated with a variety of systemic comorbidities, such as metabolic syndrome and obesity. Obesity represents a major comorbidity and has been suggested to be related to psoriasis. This nationwide population-based prospective cohort study was performed to investigate the impacts of body mass index (BMI) and waist circumference (WC) on psoriasis. We used the health check-up database and the study population consisted of subjects who had undergone health screening between January 2009 and December 2012. This study investigated patients newly diagnosed with psoriasis (International Classification of Disease, Tenth Revision, code L40) by dermatologists during the follow-up period (5.32 years), based on claims data. The total population consisted of 22 633 536 subjects, among whom 399 461 had newly developed psoriasis. Subjects with BMI of more than 30 had a higher risk of psoriasis (hazards ratio [HR], 1.118; 95% confidence interval [CI], 1.100-1.137) compared with the BMI 18.5-23 group. WC showed a dose-dependent association with psoriatic risk. Subjects with WC over 105 cm showed the highest risk of psoriasis (HR, 1.305; 95% CI, 1.261-1.349) compared with subjects with WC lower than 80/75 after adjusting for confounding factors, including BMI. The risk of psoriasis was highest in males with normal BMI and abdominal obesity (HR, 1.175; 95% CI, 1.150-1.200). Our study indicates that WC is a specific factor affecting psoriatic risk and highlights the association between abdominal obesity and psoriasis, thus increasing awareness of the role of abdominal obesity in the pathogenesis and comorbidities of psoriasis.


Assuntos
Obesidade Abdominal/complicações , Psoríase/epidemiologia , Adulto , Idoso , Índice de Massa Corporal , Feminino , Seguimentos , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Obesidade Abdominal/diagnóstico , Estudos Prospectivos , Psoríase/etiologia , República da Coreia/epidemiologia , Fatores de Risco , Fatores Sexuais , Circunferência da Cintura , Relação Cintura-Quadril
8.
Adv Exp Med Biol ; 1160: 35-41, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31041698

RESUMO

Metabolic syndrome (MetS) and obstructive sleep apnea (OSA) are related to a higher incidence of cardio-vascular diseases and mortality in patients. The aim of the study was to define the potential use of anthropometric factors for the evaluation of OSA risk in patients with diagnosed MetS. The patient group consisted of 50 obese men with MetS (mean age 49 ± 9 years). The following anthropometric indices were assessed: body mass index (BMI), neck circumference (NC), waist circumference (WC), and waist-to-hip ratio (WHR). In addition, blood glucose and lipid profile were investigated. On the basis of polysomnography, clinical symptoms, and Epworth Sleep Scale, patients were stratified into the OSA group accompanied by MetS (n = 31) and the MetS alone group taken as control (n = 19). OSA was evaluated as severe in 26 out of the 31 patients (>30 apneic episodes per hour). We found a significantly larger NC in the OSA with MetS group then that in the MetS alone group. Further, NC associated with the increase in the apnea/hypopnea index. However, the other anthropometric indices investigated failed to differentiate the two groups. We conclude that increased neck circumference in patients suffering from metabolic syndrome is a risk factor for the development of OSA.


Assuntos
Síndrome Metabólica , Apneia Obstrutiva do Sono , Adulto , Antropometria , Índice de Massa Corporal , Humanos , Masculino , Síndrome Metabólica/epidemiologia , Síndrome Metabólica/etiologia , Pessoa de Meia-Idade , Pescoço/anatomia & histologia , Fatores de Risco , Apneia Obstrutiva do Sono/complicações , Circunferência da Cintura , Relação Cintura-Quadril
9.
J Korean Acad Nurs ; 49(2): 113-125, 2019 Apr.
Artigo em Coreano | MEDLINE | ID: mdl-31064965

RESUMO

PURPOSE: The purpose of this study was to examine the effects of a daily life-based physical activity enhancement program performed by middle-aged women at risk for cardiovascular disease. METHODS: This study used a randomized control group pretest-posttest design. Middle-aged women aged 45 to 64 were recruited from two outpatient cardiology departments, and randomly assigned to an experimental group (n=28) and a control group (n=30). For the experimental group, after providing one-on-one counseling and education, we provided customized text messages to motivate them in daily life. To monitor the practice of physical activity, they also used an exercise diary and mobile pedometer for 12 weeks. Subjects' physical activities (MET-min/week) were measured using the International Physical Activity Questionnaire (IPAQ). Their physiological data were obtained by blood tests using a portable analyzer, and the data were analyzed using the SPSS 21.0/WIN program. RESULTS: There were significant differences in exercise self-efficacy, health behavior, IPAQ score, body fat, body muscle, and fasting blood sugar between the two groups. However, there were no significant differences in total cholesterol, hemoglobin A1c, high-density lipoprotein cholesterol, and waist-to-hip ratio. CONCLUSION: Strengthening physical activity in daily life without being limited by cost burden and time and space constraints. Therefore, it is essential to motivate middle-aged women at risk for cardiovascular disease to practice activities that are easily performed in their daily lives.


Assuntos
Doenças Cardiovasculares/diagnóstico , Exercício , Estilo de Vida , Avaliação de Programas e Projetos de Saúde , Glicemia/análise , Doenças Cardiovasculares/etiologia , HDL-Colesterol/sangue , Aconselhamento , Diabetes Mellitus Tipo 2/patologia , Feminino , Hemoglobina A Glicada/análise , Comportamentos Relacionados com a Saúde , Humanos , Hipertensão/patologia , Pessoa de Meia-Idade , Educação de Pacientes como Assunto , Fatores de Risco , Autoeficácia , Relação Cintura-Quadril
10.
Sichuan Da Xue Xue Bao Yi Xue Ban ; 50(1): 77-82, 2019 Jan.
Artigo em Chinês | MEDLINE | ID: mdl-31037909

RESUMO

OBJECTIVE: To compare the predictive value of different measures of obesity for metabolic syndrome (MetS) in adult Yi and Han nationality population. METHODS: A total of 3 492 urban and rural residents in Chengdu and Liangshan Yi Autonomous Prefecture participated in this study. Demographic and laboratory data were collected. Spearman correlation analysis was used to investigate the relationship between different obesity measurement indexes and MetS. Receiver operating characteristic (ROC) curve was used to compare the predictive value between different obesity measurement indexes. RESULTS: Spearman correlation analysis showed that MetS was related to body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), lipid accumulation index (LAP) and visceral adiposity index (VAI). The ROC curve showed that the LAP had the highest predictive value for MetS in both Yi and Han male adults, area under the curves (AUCs) >0.90; whereas WHR had the lowest predictive value. WHtR had high predictive value for MetS in both Yi and Han female adults (AUCs >0.88), VAI had the worst predictive value. CONCLUSION: Among different measures of obesity, LAP may have the optimal predictive value for MetS in male adults as do WHtR in female adults either in Yi or Han nationality. These findings should be confirmed through the measure of visceral fat volume and prospective study.


Assuntos
Síndrome Metabólica , Adulto , Índice de Massa Corporal , Estudos Transversais , Grupos Étnicos , Feminino , Humanos , Masculino , Obesidade , Estudos Prospectivos , Curva ROC , Fatores de Risco , Circunferência da Cintura , Relação Cintura-Quadril
11.
Int J Occup Environ Med ; 10(2): 57-65, 2019 04.
Artigo em Inglês | MEDLINE | ID: mdl-31041922

RESUMO

BACKGROUND: Shift work is associated with increased risk of cardiovascular disease, but the causes have not yet been fully established. It has been proposed that the coronary risk factors are more hazardous for shift workers, resulting in a potential interaction effect with shift work. OBJECTIVE: To analyse interaction effects of work schedule and established risk factors for coronary artery disease on the risk of myocardial infarction. METHODS: This analysis was conducted in SHEEP/VHEEP, a case-control study conducted in two counties in Sweden, comprising all first-time cases of myocardial infarction among men and women 45-70 years of age with controls stratified by sex, age, and hospital catchment area, totalling to 4648 participants. Synergy index (SI) was used as the main outcome analysis method for interaction analysis. RESULTS: There was an interaction effect between shift work and physical inactivity on the risk of myocardial infarction with SI of 2.05 (95% CI 1.07 to 3.92) for male shift workers. For female shift workers, interaction effects were found with high waist-hip ratio (SI 4.0, 95% CI 1.12 to 14.28) and elevated triglycerides (SI 5.69, 95% CI 1.67 to 19.38). CONCLUSION: Shift work and some established coronary risk factors have significant interactions.


Assuntos
Infarto do Miocárdio/epidemiologia , Medição de Risco , Jornada de Trabalho em Turnos/efeitos adversos , Idoso , Índice de Massa Corporal , Estudos de Casos e Controles , Exercício , Feminino , Humanos , Hipertrigliceridemia/epidemiologia , Masculino , Pessoa de Meia-Idade , Fatores de Risco , Fatores Sexuais , Suécia , Relação Cintura-Quadril
13.
Acta Diabetol ; 56(9): 1061-1071, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31028529

RESUMO

AIMS: To quantify epicardial adipose tissue (EAT) and visceral adipose tissue (VAT) in Chinese adults with impaired glucose regulation (IGR) or diabetes and compare the contributions of EAT and VAT to the occurrence of IGR and diabetes with those of traditional obesity indices. METHODS: Cardiac and abdominopelvic noncontrast computed tomographic images of 668 individuals were used to measure EAT and VAT volume. Multivariable logistic regression and area under the receiver operating characteristic (ROC) curve were used to illustrate the contributions of these tissues. RESULTS: Patients with IGR or diabetes had larger EAT and VAT volumes than did the controls, and the VAT volume was significantly different between the IGR and diabetic groups. In multivariable models, higher EAT or VAT volume was positively associated with the presence of IGR and diabetes. After adjusting further for body mass index (BMI) and waist-to-hip ratio (WHR), a higher EAT volume was still positively associated with IGR (odds ratio (OR) = 1.46; 95% confidence interval (CI), 1.04-2.03), and a higher VAT volume was positively associated with IGR (OR = 1.86; 95% CI, 1.15-3.02) and diabetes (OR = 1.86; 95% CI, 1.16-2.99). The areas under the curve (AUCs) of the association of EAT (AUC = 0.751; 95% CI, 0.712-0.789) and VAT (AUC = 0.752; 95% CI, 0.713-0.792) with dysglycemia (IGR + diabetes) were significantly larger than those of the traditional obesity indices (all P < 0.05). CONCLUSIONS: High EAT or VAT volume is positively associated with IGR and diabetes in Chinese adults. With a given WHR and BMI, such an association still exists to some extent. The correlation may be stronger than those of the traditional obesity indices.


Assuntos
Tecido Adiposo/metabolismo , Diabetes Mellitus/metabolismo , Intolerância à Glucose/metabolismo , Gordura Intra-Abdominal/metabolismo , Pericárdio , Tecido Adiposo/diagnóstico por imagem , Tecido Adiposo/patologia , Adulto , Grupo com Ancestrais do Continente Asiático/estatística & dados numéricos , Índice de Massa Corporal , China/epidemiologia , Estudos Transversais/legislação & jurisprudência , Diabetes Mellitus/diagnóstico , Diabetes Mellitus/epidemiologia , Diabetes Mellitus/patologia , Feminino , Intolerância à Glucose/diagnóstico , Intolerância à Glucose/epidemiologia , Intolerância à Glucose/patologia , Humanos , Gordura Intra-Abdominal/diagnóstico por imagem , Gordura Intra-Abdominal/patologia , Masculino , Pessoa de Meia-Idade , Obesidade/complicações , Obesidade/epidemiologia , Obesidade/metabolismo , Obesidade/patologia , Pericárdio/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Relação Cintura-Quadril , Adulto Jovem
14.
Nat Commun ; 10(1): 1585, 2019 04 05.
Artigo em Inglês | MEDLINE | ID: mdl-30952852

RESUMO

Sleep is an essential human function but its regulation is poorly understood. Using accelerometer data from 85,670 UK Biobank participants, we perform a genome-wide association study of 8 derived sleep traits representing sleep quality, quantity and timing, and validate our findings in 5,819 individuals. We identify 47 genetic associations at P < 5 × 10-8, of which 20 reach a stricter threshold of P < 8 × 10-10. These include 26 novel associations with measures of sleep quality and 10 with nocturnal sleep duration. The majority of identified variants associate with a single sleep trait, except for variants previously associated with restless legs syndrome. For sleep duration we identify a missense variant (p.Tyr727Cys) in PDE11A as the likely causal variant. As a group, sleep quality loci are enriched for serotonin processing genes. Although accelerometer-derived measures of sleep are imperfect and may be affected by restless legs syndrome, these findings provide new biological insights into sleep compared to previous efforts based on self-report sleep measures.


Assuntos
Polissonografia/métodos , Transtornos do Sono-Vigília/genética , Sono/genética , Acelerometria/métodos , Ritmo Circadiano , Humanos , Polimorfismo de Nucleotídeo Único , Serotonina/genética , Serotonina/metabolismo , Transtornos do Sono-Vigília/diagnóstico , Relação Cintura-Quadril
15.
High Blood Press Cardiovasc Prev ; 26(3): 239-246, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31020550

RESUMO

INTRODUCTION: Hypertension (HT) is considered as a major determinant of cardiovascular complications. However, few studies have addressed HT prevalence among adults aged 60 years and older in the northern mountainous region of Vietnam. AIM: To determine the prevalence of HT and its risk factors in the elderly in that area. METHODS: A cross-sectional study was conducted in a study area in the northern of Vietnam. We interviewed 354 adults aged 60 years or over who were randomly selected, and then measured their blood pressure. RESULTS: The overall HT prevalence was 62.15%. The isolated systolic hypertension (ISH) prevalence was 22.88%. There was a slight decrease in the proportion of HT by stage 1, stage 2 and stage 3 respectively. The univariate and multivariate logistic regression analysis indicated some risk factors for HT including age groups, body mass index (BMI) and waist-hip ratio (WHR) (p < 0.05). Furthermore, we also found that the risk factors of ISH was obesity status classified by BMI category and WHR (p < 0.05). In particularly, the ethnicity was statistically significantly associated with ISH. CONCLUSION: Our data showed a high prevalence of hypertension in the elderly in studied area. The risk factors for HT and ISH among studied subjects included age groups, ethnic groups, BMI and WHR. Hence, these findings are important for policy-making related to launch public health prevention and control campaigns for hypertension among older adults in the northern mountainous region of Vietnam.


Assuntos
Hipertensão/etnologia , Saúde da População Rural/etnologia , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Pressão Sanguínea , Índice de Massa Corporal , Estudos Transversais , Feminino , Inquéritos Epidemiológicos , Humanos , Hipertensão/diagnóstico , Hipertensão/fisiopatologia , Masculino , Pessoa de Meia-Idade , Obesidade/etnologia , Obesidade/fisiopatologia , Prevalência , Medição de Risco , Fatores de Risco , Vietnã/epidemiologia , Relação Cintura-Quadril
16.
BMC Public Health ; 19(1): 391, 2019 Apr 11.
Artigo em Inglês | MEDLINE | ID: mdl-30971258

RESUMO

BACKGROUND: Persons of African and Middle-Eastern origin living in European countries have a high prevalence of type 2 diabetes, accompanied by high prevalence of obesity among women but not always among men. The aim of this study was to examine whether there are differences in the association between anthropometric measures and glucose levels measured with glycated haemoglobin and fasting blood glucose among persons of migrant origin in Finland. METHODS: Cross-sectional population-based data of the 30-64 year-old participants in the health examination of the Migrant Health and Wellbeing Study was used, selecting persons without diabetes (Russian origin n = 293, Somali origin n = 184, Kurdish origin n = 275). The reference group were non-diabetic participants in the Health 2011 Survey (n = 653), representative of the general Finnish population. Anthropometric measures included body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHtR) and waist-to-hip ratio (WHR, available for Maamu Study participants only). RESULTS: Depending on whether continuous or categorical anthropometric measures were used, age, sex and anthropometrics explained 13-18% of variation in HbA1c among persons of Russian origin, 5-10% among persons of Somali origin, 1-3% among persons of Kurdish origin and 11-13% among the general population. Also depending on whether continuous or categorical anthropometric measures were used, age, sex and anthropometrics explained 13-19% of variation in fasting blood glucose among persons of Russian origin, 15-20% among persons of Somali origin, 13-17% among persons of Kurdish origin and 16-17% among the general population. With exception for BMI, strength of the association between continuous anthropometric measures and HbA1c was significantly lower among persons of Kurdish origin compared with the general Finnish population (p = 0.044 for WC and p = 0.040 for WHtR). CONCLUSIONS: A low degree of association between anthropometric measures and HbA1c was observed among persons of Kurdish origin. Findings of this study suggest caution is warranted when using HbA1c as a screening tool for glucose impairment among persons without diabetes in populations of diverse origin.


Assuntos
Diabetes Mellitus Tipo 2/etnologia , Diabetes Mellitus Tipo 2/epidemiologia , Grupos Étnicos/estatística & dados numéricos , Hemoglobina A Glicada/análise , Migrantes/estatística & dados numéricos , Adulto , Antropometria , Índice de Massa Corporal , Estudos Transversais , Feminino , Finlândia/epidemiologia , Inquéritos Epidemiológicos , Humanos , Masculino , Pessoa de Meia-Idade , Prevalência , Fatores de Risco , Federação Russa/etnologia , Somália/etnologia , Circunferência da Cintura , Razão Cintura-Estatura , Relação Cintura-Quadril
17.
Eur J Endocrinol ; 180(6): 373-380, 2019 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-30991360

RESUMO

Objective To explore whether gestational prolactin and breast increase are markers of metabolic health in pregnancy and on long-term, in PCOS. Design Follow-up study. Women with PCOS, according to the Rotterdam criteria (n = 239), former participants of the randomized controlled trial (RCT) PregMet were invited, 131 participated in the current follow-up study, at mean 8 years after pregnancy. Methods Metformin 2000 mg/day or placebo from first trimester to delivery in the original RCT. No intervention in the current study. Prolactin was analyzed in the first trimester and at gestational week 32 and metabolic characteristics which are part of the metabolic syndrome and measures of glucose homeostasis were examined. Metabolic health was also evaluated according to breast increase versus lack of breast increase during pregnancy. Results Prolactin increase in pregnancy was negatively correlated to BMI (P = 0.007) and systolic blood pressure (P ≤ 0.001) in gestational week 32. Prolactin at gestational week 32 was negatively correlated to BMI (P = 0.044) and visceral fat area (P = 0.028) at 8-year follow-up in an unadjusted model. Prolactin at gestational week 32 showed no associations to metabolic health at follow-up when baseline BMI was adjusted for. Women who reported lack of breast increase during pregnancy, had higher BMI (P = 0.034), waist-hip ratio (P = 0.004), visceral fat area (P = 0.050), total cholesterol (P = 0.022), systolic (P = 0.027) and diastolic blood pressure (P = 0.011) at 8-year follow-up. Conclusion High prolactin levels and breast increase in pregnancy were associated with a more favorable long-term metabolic health in women with PCOS. Both prolactin and breast increase may be mediated by gestational BMI.


Assuntos
Mama/crescimento & desenvolvimento , Síndrome do Ovário Policístico/sangue , Síndrome do Ovário Policístico/fisiopatologia , Complicações na Gravidez/fisiopatologia , Prolactina/sangue , Adolescente , Adulto , Pressão Sanguínea , Índice de Massa Corporal , Feminino , Seguimentos , Idade Gestacional , Humanos , Hipoglicemiantes , Resistência à Insulina , Gordura Intra-Abdominal/patologia , Metformina/administração & dosagem , Pessoa de Meia-Idade , Síndrome do Ovário Policístico/patologia , Gravidez , Complicações na Gravidez/sangue , Complicações na Gravidez/patologia , Ensaios Clínicos Controlados Aleatórios como Assunto , Relação Cintura-Quadril , Adulto Jovem
18.
Nutr Hosp ; 36(1): 32-38, 2019 Mar 07.
Artigo em Espanhol | MEDLINE | ID: mdl-30821164

RESUMO

Introduction: Objective: to determinate the relationship between the anthropometric profile and the postural and dynamic balance in children from six to nine years old. Background: balance or postural control is a complex motor skill that aims to achieve an adequate postural balance from multiple sensorimotor processes in both static and dynamic activities. Although the relationship between anthropometric measurements and postural balance in children has not been clearly defined, it has been suggested that they could negatively influence postural control. Methods: the sample included 158 schoolchildren (88 men and 70 women) who were between six and nine years old. The variables of the anthropometric profile studied were body mass, bipedal stature, body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), sum skin-folds, body composition and somatotype. In addition, the static and dynamic postural balance was measured through posturography and the Y-Balance Test, respectively. The anthropometric measurements were correlated with the results of the postural balance tests. Results: moderate positive correlations between static postural balance, mainly in closed eyes condition, and BMI, PC, sum skin-folds, fat mass and endomorphy were found. Regarding the dynamic postural balance, moderate negative correlations were observed between the performance of the Y-Balance Test and body mass, bipedal stature, BMI, sum skin-folds, fat mass, skin mass and endomorphy. Conclusion: children with higher adiposity and/or predominance of the endomorphic component have a lower performance in static and dynamic postural balance tests.


Assuntos
Antropometria , Equilíbrio Postural/fisiologia , Composição Corporal , Estatura , Índice de Massa Corporal , Criança , Feminino , Humanos , Masculino , Destreza Motora , Pregas Cutâneas , Somatotipos , Circunferência da Cintura , Relação Cintura-Quadril
19.
Nutr Hosp ; 36(1): 80-86, 2019 Mar 07.
Artigo em Inglês | MEDLINE | ID: mdl-30836761

RESUMO

Introduction: Background: the aim of this study was to evaluate the intake of nutrients, anthropometric parameters, health indicators, adipokines and insulin levels in a population of young undergraduates. Method: in this study, 378 young undergraduates were invited to participate. Due to the inclusion criteria and their own decision of participating, 90 attended the anthropometric, health indicators: waist circumference (WC), waist to hip ratio (WHR), waist to height ratio (WHtR), and homeostatic model assessment-insulin resistance index (HOMA-IR) studies and completed the questionnaire of frequency of food intake; and 34 participants were selected to perform the determination of biochemical parameters, insulin and adipokines levels: leptin, IL-6, IL-8, tumor necrosis factor alpha (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and hepatocyte growth factor (HGF). Results: according to WC, WHR and WHtR, obese population showed health, cardiovascular and metabolic risk. Overweight population showed cardiometabolic risk. In general, lipid intake was higher than 30%, being animal fat the most consumed. The levels of leptin (women: 17.2 ± 9.2, 28 ± 11.3, 36.8 ± 17.8; men: 4.3 ± 3.6, 9.5 ± 3.1, 24.6 ± 16.4 to lean overweight and obese, respectively) and insulin (women: 408 ± 182, 438 ± 187, 768 ± 167; men: 244 ± 88, 520 ± 256, 853 ± 590) increased along with body mass index (BMI), body fat percentage (BFP), visceral fat area (VFA), WC, WHR and WHtR. Lean (2.4 ± 1.3), overweight (2.2 ± 0.9) and obese (4.3 ± 1.1) women and overweight (2.8 ± 1.2) and obese (5.0 ± 3.1) men showed insulin resistance according to HOMA-IR. Significant correlation between leptin and HOMA-IR was found (p = 0.41). BMI, BFP, VFA, WC, and WHtR positively correlated with leptin (p = 0.67, 0.75, 0.66, 0.60, 0.67, respectively) and insulin (p = 0.37, 0.40, 0.48, 0.49, 0.42, respectively), while WHR only with insulin (p = 0.43). No significant differences were found in the other adipokines. Conclusion: the use of health indicators such VFA, WC, WHR, WHtR and HOMA-IR are useful tools in the determination of health, cardio vascular and metabolic risk and are correlated with levels of leptin and insulin in the studied population.


Assuntos
Adipocinas/sangue , Antropometria , Dieta , Adiposidade , Composição Corporal , Índice de Massa Corporal , Estudos Transversais , Comportamento Alimentar , Feminino , Humanos , Resistência à Insulina , Leptina/sangue , Masculino , Obesidade/sangue , Sobrepeso/sangue , Fatores Sexuais , Estudantes , Circunferência da Cintura , Relação Cintura-Quadril , Adulto Jovem
20.
Cent Eur J Public Health ; 27(1): 37-43, 2019 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-30927395

RESUMO

OBJECTIVES: Asians (including Chinese, Japanese and Koreans), who generally have a relatively smaller body size and a lower mean body mass index (BMI), have a relatively higher risk of developing android-type obesity than westerners. Substitution of alanine for threonine (Ala54Thr) on the FABP2 gene (rs 1799883) is related to insulin resistance and obesity. However, few studies have examined this substitution in Koreans, and the number of Korean subjects in those studies is limited. For this reason, we investigated the differences between the FABP2 Ala54Thr polymorphism and obesity, hemodynamic variables, blood lipid profile results, and insulin resistance among middle-aged Korean women with abdominal obesity. METHODS: We studied 243 middle-aged community-dwelling Korean women with abdominal obesity from Gyeonggi Province, Republic of Korea, who had no history of taking chronic medications. We examined each subject (n = 243) for the presence of FABP2 Ala54Thr polymorphism using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Subjects were also examined for obesity hemodynamic variables (n = 243), lipid profiles (n = 142), and insulin resistance (n = 142). RESULTS: Of the 243 subjects, 117 had AA ("normal") homozygotic genotype, 100 had AT heterozygotic genotype, and 26 had TT homozygotic genotype for the FABP2 Ala54Thr polymorphism. The AT heterozygotic individuals had a significantly higher mean waist-to-hip ratio, abdominal fat area, and visceral fat area than individuals with other genotypes. TT homozygotic individuals had higher mean triglyceride and fasting glucose levels than individuals with other genotypes. CONCLUSIONS: The results of this study show that the FABP2 Ala54Thr polymorphism was associated with central obesity and obesity-related metabolic syndrome among middle-aged Korean women.


Assuntos
Proteínas de Ligação a Ácido Graxo/genética , Síndrome Metabólica/genética , Obesidade Abdominal/genética , Reação em Cadeia da Polimerase/métodos , Análise do Polimorfismo de Comprimento de Fragmentos Amplificados , Feminino , Genótipo , Humanos , Síndrome Metabólica/fisiopatologia , Pessoa de Meia-Idade , Obesidade Abdominal/fisiopatologia , Polimorfismo Genético , República da Coreia , Relação Cintura-Quadril
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