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1.
Medicine (Baltimore) ; 99(22): e20386, 2020 May 29.
Artigo em Inglês | MEDLINE | ID: mdl-32481425

RESUMO

Use of polyacrylate-polyalcohol copolymer (PPC) after endoscopic correction (EC) of vesico-ureteral reflux (VUR) is highly effective but is associated with a higher risk of obstructive complications (OC) compared with other implants. We undertook a STROBE compliant retrospective investigation and studied the OC risk factors to increase the practical safety of PPC.Overall, 798 patients (464 [58.1%] girls and 334 [41.9%]) boys) from 5 hospitals in whom PPC was routinely used were evaluated retrospectively. The patients were subdivided into 2 groups. Group I consisted of 754 (94.5%) children (449 [59.5%] girls and 305 [40.5%] boys) without OC. Median age was 41 months [Q1: 18.0; Q3: 81.0]. Group II comprised 44 (5.5%) patients (29 [65.9%] boys and 15 [34.1%] girls) experiencing OC, and their median age was 21.5 months [Q1: 12.0; Q3: 43.0]. Clinical and renal ultrasound examinations were carried out 1 day and 1 month after EC, and then every 6 months after EC. At the follow-up examination approximately 6 months after EC, voiding cysto-urethrography (VCUG) was performed. All patients with OC underwent diuretic renography.OC occurred in 44 (5.5%) of 798 children, in some cases as late as 60 months after endoscopic injection of the bulking agent PPC for correction of VUR. Univariate analysis revealed that younger age (P < .001), higher grade of VUR (P < .001), male gender (P < .001), second injection (P = .003), and EC injection using hydrodistension implantation technique (HIT; P < .001) represented significant risk factors. At multivariate analysis, only male gender (P = .0078), younger age (P = .0044), HIT technique (P < .0001), and second injection (P = .04) represented significant risk factors for the occurrence of OC.We identified young age, male gender, high reflux grade, HIT technique, and second endoscopic injections as factors associated with the risk of OC after EC of VUR using PPC as a bulking agent. Thus, patients who have undergone EC with PPC must be monitored sonographically for occurrence of OC for at least 60 months after the intervention.


Assuntos
Resinas Acrílicas/uso terapêutico , Polímeros/uso terapêutico , Obstrução Ureteral/etiologia , Ureteroscopia/métodos , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Estudos Retrospectivos , Fatores de Risco , Ureteroscopia/efeitos adversos , Refluxo Vesicoureteral
3.
J Dent ; 88: 103163, 2019 09.
Artigo em Inglês | MEDLINE | ID: mdl-31276747

RESUMO

OBJECTIVES: Although there is some consensus that carious lesions in early stages (non-cavitated) could be treated using sealants, neither the type of materials nor their use in lesions with localized enamel breakdown (microcavitated) has been reported To compare the efficacy of resin or glass ionomer (GI) sealants in arresting microcavitated carious lesions (ICDAS 3) in first permanent molars. MATERIALS AND METHODS: A double-blinded randomized controlled clinical trial was conducted in 41 healthy 6 to 11-year-old children. At the baseline examination, each subject had at least one carious lesion classified as ICDAS 3 on the first permanent molar. One hundred fifty-one lesions were randomized into: Group 1: resin sealants (76 lesions) and Group 2: GI sealant (75 lesions). Carious lesion progression was assessed clinically and radiographically. Progression and retention failure were the outcomes used for group comparisons at p-value<0.05. RESULTS: After a two-year follow-up, only one lesion progressed to ICDAS 5, without statistically significant differences between the groups (χ2(1) = 0.90, p = 0.53). Radiographically, 100 lesions (98%) were arrested and 2 (2%) showed radiographic progression, without differences between groups (χ2(1) = 0.93, p = 0.93). At 2 years, complete retention was observed in 77% of the resin-based and in 83% of the GI sealants, without statistical differences between type of sealant (χ2(1) = 0.71, p = 0.48). The multilevel mixed model demonstrated that location and type of sealant did not affect retention rates (χ2(1) = 24,98, p < 0.001). CONCLUSION: Sealing ICDAS 3 carious lesions in permanent molars appears to be effective in arresting lesions after a two-year follow-up. Clinicaltrials.gov: RCTICDAS3/2015. CLINICAL SIGNIFICANCE: Minimally invasive approaches for carious lesion management have been promoted. Using sealants for the treatment of microcavitated lesions (ICDAS 3) appears predictable in the routine practice, without predilection for resin or glass ionomer materials. In addition to preserving tooth structure, this strategy reduces chair-time, dental fear and costs, and increases coverage to dental care.


Assuntos
Resinas Acrílicas/uso terapêutico , Cárie Dentária/prevenção & controle , Cimentos de Ionômeros de Vidro/uso terapêutico , Selantes de Fossas e Fissuras/uso terapêutico , Resinas Acrílicas/química , Criança , Resinas Compostas/química , Resinas Compostas/uso terapêutico , Método Duplo-Cego , Cimentos de Ionômeros de Vidro/química , Humanos , Dente Molar/patologia , Selantes de Fossas e Fissuras/química , Dióxido de Silício
4.
J Fr Ophtalmol ; 42(6): 642-654, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30929965

RESUMO

Lacrycon® is a preservative-free hypotonic artificial tear for the treatment of dry eye syndrome containing hyaluronic acid, carbomer, and glycerol. Lacrycon has been used for many years; this is the first comprehensive review of clinical efficacy and tolerability. Eight clinical studies (1992-2013) were reviewed. Comparators included phosphate-buffered saline (Phase I) and active controls (Phase II: Lacrisol™; Phase III: Gel-larmes™, Lacrisol, Hyalistil®, Vismed®, or the currently prescribed tear substitute). Administration schedules varied from 3 to 8 instillations per day for 7 to 84 days, and evaluation timepoints varied between studies. Pre-corneal retention of Lacrycon was 22% better than phosphate-buffered saline in terms of AUC (P=0.048). Patients' evaluation of efficacy was better for Lacrycon than Gel-larmes on Day 15 and 45 (P<0.05) and similar on Day 90 (P>0.05); there was no difference (P>0.05) versus Hyalistil (Day 30) or Vismed (Day 35 and 85). Functional tests were either in favor of Lacrycon (P<0.05) (fluorescein test [versus Gel-larmes/Lacrisol/Hyalistil], tear break-up time [TBUT] and rose Bengal test, Schirmer I test, and tear meniscus [versus Lacrisol]), or there was no difference between treatments (P>0.05) (fluorescein test [versus Vismed], TBUT and rose Bengal test [versus Gel-larmes], Schirmer I test [versus Gel-larmes/Lacrisol/Hyalistil/VisMed], tear meniscus [versus Lacrisol/Hyalistil], Oxford Grading Score, OSDI, van Bijsterveld score, and conjunctival hyperemia [versus Vismed]). Lacrycon was better tolerated than most comparators and had a similar safety profile to Vismed. No comparison showed favored the comparator over Lacrycon. These good efficacy, tolerability and safety data support the use of Lacrycon in dry eye syndrome.


Assuntos
Resinas Acrílicas/uso terapêutico , Síndromes do Olho Seco/tratamento farmacológico , Glicerol/uso terapêutico , Ácido Hialurônico/uso terapêutico , Lubrificantes Oftálmicos/uso terapêutico , Ensaios Clínicos como Assunto , Esquema de Medicação , Humanos , Lubrificantes Oftálmicos/efeitos adversos , Lubrificantes Oftálmicos/química
5.
Cochrane Database Syst Rev ; 2: CD001532, 2019 02 20.
Artigo em Inglês | MEDLINE | ID: mdl-30784039

RESUMO

BACKGROUND: Vesicoureteric reflux (VUR) results in urine passing retrograde up the ureter. Urinary tract infections (UTI) associated with VUR have been considered a cause of permanent renal parenchymal damage in children with VUR. Management has been directed at preventing UTI by antibiotic prophylaxis and/or surgical correction of VUR. This is an update of a review first published in 2004 and updated in 2007 and 2011. OBJECTIVES: The aim of this review was to evaluate the available evidence for both benefits and harms of the currently available treatment options for primary VUR: operative, non-operative or no intervention. SEARCH METHODS: We searched the Cochrane Kidney and Transplant Specialised Register to 3 May 2018 through contact with the Information Specialist using search terms relevant to this review. Studies contained in the Specialised Register are identified through search strategies specifically designed for CENTRAL, MEDLINE, and EMBASE; handsearching conference proceedings, and searching the International Clinical Trials Register (ICTRP) Search Portal and ClinicalTrials.gov. SELECTION CRITERIA: RCTs in any language comparing any treatment of VUR and any combination of therapies. DATA COLLECTION AND ANALYSIS: Two authors independently determined study eligibility, assessed quality and extracted data. Dichotomous outcomes were expressed as risk ratios (RR) with 95% confidence intervals (CI) and continuous data as mean differences (MD) with 95% CI. Data were pooled using the random effects model. MAIN RESULTS: Thirty four studies involving 4001 children were included. Interventions included; long-term low-dose antibiotics, surgical reimplantation of ureters, endoscopic injection treatment, probiotics, cranberry products, circumcision, and oxybutynin. Interventions were used alone and in combinations. The quality of conduct and reporting of these studies was variable, with many studies omitting crucial methodological information used to assess the risk of bias. Only four of the 34 studies were considered at low risk of bias across all fields of study quality. The majority of studies had many areas of uncertainty in the risk of bias fields, reflecting missing detail rather than stated poor design.Low-dose antibiotic prophylaxis compared to no treatment/placebo may make little or no difference to the risk of repeat symptomatic UTI (9 studies, 1667 children: RR 0.77, 95% CI 0.54 to 1.09; low certainty evidence) and febrile UTI (RR 0.83, 95% CI 0.56 to 1.21; low certainty evidence) at one to two years. At one to three years, antibiotic prophylaxis made little or no difference to the risk of new or progressive renal damage on DMSA scan (8 studies, 1503 children: RR 0.73, 95% CI 0.33 to 1.61; low certainty evidence). Adverse events were reported in four studies with little or no difference between treatment groups (1056 children: RR 0.94, 95% CI 0.81 to 1.08; ), but antibiotics increased the likelihood of bacterial drug resistance threefold (187 UTIs: RR 2.97, 95% CI 1.54 to 5.74; moderate certainty evidence).Seven studies compared long-term antibiotic prophylaxis alone with surgical reimplantation of ureters plus antibiotics, but only two reported the outcome febrile UTI (429 children). Surgery plus antibiotic treatment may reduce the risk of repeat febrile UTI by 57% (RR 0.43, 95% CI 0.27 to 0.70; moderate certainty evidence). There was little or no difference in the risk of new kidney defects detected using intravenous pyelogram at 4 to 5 years (4 studies, 572 children, RR 1.09, 95% CI 0.79 to 1.49; moderate certainty evidence)Four studies compared endoscopic injection with antibiotics alone and three reported the outcome febrile UTI. This analysis showed little or no difference in the risk of febrile UTI with endoscopic injection compared to antibiotics (RR 0.74, 95% CI 0.31 to 1.78; low certainty evidence). Four studies involving 425 children compared two different materials for endoscopic injection under the ureters (polydimethylsiloxane (Macroplastique) versus dextranomer/hyaluronic acid polymer (Deflux), glutaraldehyde cross-linked (GAX) collagen (GAX) 35 versus GAX 65 and Deflux versus polyacrylate polyalcohol copolymer (VANTRIS)) but only one study (255 children, low certainty evidence) had the outcome of febrile UTI and it reported no difference between the materials. All four studies reported rates of resolution of VUR, and the two studies comparing Macroplastique with Deflux showed that Macroplastique was probably superior to dextranomer/hyaluronic acid polymer (3 months: RR 0.50, 95% CI 0.33 to 0.78; 12 months: RR 0.54 95% CI 0.35 to 0.83; low certainty evidence)Two studies compared probiotic treatment with antibiotics and showed little or no difference in risk of repeat symptomatic UTI (RR 0.82 95% CI 0.56 to 1.21; low certainty evidence)Single studies compared circumcision with antibiotics, cranberry products with no treatment, oxybutynin with placebo, two different surgical techniques and endoscopic injection with no treatment. AUTHORS' CONCLUSIONS: Compared with no treatment, the use of long-term, low-dose antibiotics may make little or no difference to the number of repeat symptomatic and febrile UTIs in children with VUR (low certainty evidence). Considerable variation in the study designs and subsequent findings prevented drawing firm conclusions on efficacy of antibiotic treatment.The added benefit of surgical or endoscopic correction of VUR over antibiotic treatment alone remains unclear since few studies comparing the same treatment and with relevant clinical outcomes were available for analysis.


Assuntos
Infecções Urinárias/prevenção & controle , Refluxo Vesicoureteral/terapia , Resinas Acrílicas/uso terapêutico , Antibacterianos/uso terapêutico , Antibioticoprofilaxia , Criança , Colágeno/uso terapêutico , Dextranos/uso terapêutico , Dimetilpolisiloxanos/uso terapêutico , Feminino , Febre/etiologia , Febre/prevenção & controle , Humanos , Ácido Hialurônico/uso terapêutico , Rim/anormalidades , Masculino , Probióticos/uso terapêutico , Ensaios Clínicos Controlados Aleatórios como Assunto , Reimplante , Ureter/cirurgia , Infecções Urinárias/complicações , Refluxo Vesicoureteral/complicações
6.
Clin Exp Nephrol ; 23(6): 825-833, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30771042

RESUMO

PURPOSE: To assess the safety and effectiveness of transcatheter arterial embolization (TAE) with tris-acryl gelatin microspheres for patients with symptomatic enlarged polycystic liver disease (PCLD). MATERIALS AND METHODS: This prospective study was approved by our hospital's institutional review board and planned for patients with symptoms related to enlarged PCLD, such as distended abdomen, gastrointestinal obstruction and abdominal pain. Hemi-hepatic embolization with tris-acryl gelatin microspheres was performed in the hepatic artery supplying the hepatic lobe that showed the predominant presence of cysts. Each patient underwent an assessment of liver function, a questionnaire survey about symptoms, measurement of the estimated volume of the whole liver before and after TAE, and an assessment of complications associated with TAE. RESULTS: Five patients (four females, one male; mean age 52.6 ± 9.1 years) were treated. All five patients successfully completed TAE. The left lobe was treated in three patients and the right in two. After TAE, post-embolization syndrome and transient elevation of white blood cells, aspartate aminotransferase, and alanine aminotransferase occurred in all patients, but none developed hepatic insufficiency or severe complications. The mean whole liver volume was 7406 ± 2323 mL before TAE, and 6995 ± 2139 mL (95.1 ± 5.2% of the pre-therapeutic value) at 3 months and 6855 ± 2246 mL (93.3 ± 9.7%) at 12 months after TAE. Three of the five patients reported an improvement of clinical symptoms within 12 months after TAE. CONCLUSION: TAE with microspheres can be a safe and effective treatment for symptomatic enlarged PCLD.


Assuntos
Resinas Acrílicas/uso terapêutico , Cistos/terapia , Embolização Terapêutica/estatística & dados numéricos , Gelatina/uso terapêutico , Hepatopatias/terapia , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos
7.
J Plast Reconstr Aesthet Surg ; 72(5): 848-862, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30658951

RESUMO

This article is a follow up to "Early and late complications of polyalkimide gel (Bio-Alcamid)".1 It is a summary of late complications that have developed in patients treated with Bio-Alcamid for HIV lipoatrophy following extended follow up of 10 years.


Assuntos
Resinas Acrílicas/efeitos adversos , Preenchedores Dérmicos/efeitos adversos , Síndrome de Lipodistrofia Associada ao HIV/cirurgia , Resinas Acrílicas/uso terapêutico , Preenchedores Dérmicos/uso terapêutico , Humanos , Cirurgia Plástica/efeitos adversos , Cirurgia Plástica/métodos
8.
Tidsskr Nor Laegeforen ; 139(2)2019 01 29.
Artigo em Inglês, Norueguês | MEDLINE | ID: mdl-30698387

RESUMO

Periurethral injection offers an alternative to the current main method for surgical treatment of stress incontinence in women, which is a polypropylene sling that is placed without tension below the mid-urethra. Injection therapy is a simple, gentle method that provides significant improvement in the degree of leakage and quality of life, but the results are not on a par with the polypropylene sling. Injection therapy may be relevant when the main method is not suitable or desired.


Assuntos
Resinas Acrílicas/uso terapêutico , Hidrogéis/uso terapêutico , Incontinência Urinária por Estresse/terapia , Resinas Acrílicas/efeitos adversos , Feminino , Humanos , Hidrogéis/efeitos adversos , Injeções/métodos , Resultado do Tratamento , Uretra
9.
J Prosthodont ; 28(1): e110-e117, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29888488

RESUMO

PURPOSE: Acrylic resin properties are susceptible to change over the duration of use, thereby decreasing prosthesis longevity. To make the material less susceptible to the action of external agents such as stain-causing liquids and cleaning solutions, polishing procedures are recommended. A specific mechanical polishing procedure performed regularly was evaluated regarding the biofilm adhesion, surface roughness (Ra), color stability (ΔE), and mass changes in acrylic resin artificial teeth. MATERIALS AND METHODS: Sixty artificial teeth divided into two groups (n = 30) were immersed in distilled water (WT) and coffee (CF). These groups were then subdivided (n = 10) according to the type of polishing procedure administered: no polishing, biweekly polishing (once every 2 weeks) (pol 1), or monthly polishing (once a month) (pol 2), using aluminum oxide paste and a felt polishing wheel attached to an electric motor at a speed of 3000 rpm. Properties were evaluated at baseline and after 4, 8, 12, and 24 months of simulated immersion. At the end, the adhesion of Candida albicans and Streptococcus mutans multispecies biofilm in all groups was assessed. RESULTS: The CF group showed an increased Ra and weight, and a significantly greater ΔE compared to the WT group. The polishing procedure reduced Ra and minimized the stains caused by coffee, without losing mass, with the biweekly regime more effective than the monthly regime. Also, polishing reduced the adhesion of biofilm in the CF groups, again with the biweekly regime the most effective. CONCLUSIONS: When performed regularly, the mechanical polishing procedure tested reduces the changes in artificial teeth subjected to immersion in coffee, with the biweekly frequency most effective regarding the properties evaluated.


Assuntos
Resinas Acrílicas/uso terapêutico , Aderência Bacteriana , Biofilmes , Polimento Dentário , Pigmentação em Prótese , Dente Artificial , Candida albicans/crescimento & desenvolvimento , Polimento Dentário/efeitos adversos , Polimento Dentário/métodos , Streptococcus mutans/crescimento & desenvolvimento , Propriedades de Superfície
10.
J Prosthodont ; 28(1): e383-e394, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-29855127

RESUMO

PURPOSE: The purpose of this in vitro study was to evaluate the cytotoxic and apoptotic effects of seven new-generation all-ceramic materials for CAD/CAM (Lava Ultimate [LU], VITA Mark II [VM], InCoris TZI [IC], IPS e.max CAD [EM], VITA Suprinity [VS], Cerasmart [CS], IPS Empress CAD [EC]) and six provisional materials (Protemp 4 [PT], Telio CAD [TC], CAD-Temp [CT], Telio Lab [TL], Temdent Classic [TD], Telio CS C&B [TS]) on L929 mouse fibroblast cells. MATERIALS AND METHODS: 24 disc-shaped specimens (∅ = 5 mm, h = 2 mm) were prepared from each test material. Medium extracts were collected at the 1st, 3rd, and 7th days for each group and tested using the L929 cell line. Cytotoxicity was evaluated using XTT assay, and apoptosis was determined by Annexin-V/PI staining. Data were analyzed using one-way ANOVA, Tukey's multiple comparison tests at a significance level of p < 0.05. RESULTS: The cell viability results among all-ceramic material groups after the 1st and 7th days of incubation periods showed statistically significant differences (p < 0.05). There were significant differences within the ceramic groups in different incubation periods regarding apoptosis rate (p < 0.05). Throughout the entire test period, LU and VM from the CAD/CAM all-ceramic materials and PT and TC from the provisional restoration materials showed cell viability higher than 90%. EC and TD showed the lowest cell viability and highest apoptosis rates in their own groups. For the provisional materials, there were significant differences in cell viability and apoptosis rate in all the incubation periods for each material (p < 0.05). CONCLUSIONS: Although some new-generation CAD/CAM and provisional restoration materials display slight cytotoxicity values, the results are still within the reliable range, and they can safely be used in clinical conditions.


Assuntos
Cerâmica/uso terapêutico , Fibroblastos/efeitos dos fármacos , Resinas Acrílicas/efeitos adversos , Resinas Acrílicas/uso terapêutico , Animais , Apoptose/efeitos dos fármacos , Sobrevivência Celular/efeitos dos fármacos , Cerâmica/efeitos adversos , Resinas Compostas/efeitos adversos , Resinas Compostas/uso terapêutico , Materiais Dentários/efeitos adversos , Materiais Dentários/uso terapêutico , Porcelana Dentária/efeitos adversos , Porcelana Dentária/uso terapêutico , Técnicas In Vitro , Camundongos
11.
Urol J ; 16(4): 361-365, 2019 Aug 18.
Artigo em Inglês | MEDLINE | ID: mdl-30318569

RESUMO

PURPOSE: To compare the efficacy of two bulking agents, Dextranomer-Hyaluronic Acid (DxHA) and Polyacrylate-Polyalcohol Copolymer (PPC) used for endoscopic treatment of vesicoureteral reflux (VUR). MATERIALS AND METHODS: We endoscopically treated 125 patients (89 girls and 36 boys) diagnosed with VUR grades I-V, comprising a total of 174 refluxing ureters (RUs). Patients were categorized into two groups, 99 (56,9%) RUs were treated with DxHA (Group 1) and 75 (43,1%) RUs with PPC (Group 2). RUs treated with both bulking agents were excluded. The success of treatment was evaluated with postoperative VCUG at 3- and 12-months after the endoscopic procedure, only complete resolution of VUR was considered as treatment success. Data was collected and analyzed retrospectively. Statistical calculations were performed using the Chi-square test. RESULTS: After a single injection 80,0% (60/75) and 68,7% (68/99 RUs) of RUs resolved completely when treated with PPC and DxHA, respectively (P = .094). A second injection of PPC healed another 10 RUs (total 93,3%), whereas DxHA resolved additional 16 RUs (total 84,8%) (P = .097). A third injection was needed for 1 RU, treated with PPC and another 3 RUs with DxHA. Twelve months post-operatively, we achieved a total resolution rate of 94,7% (71/75 RUs) with PPC, while DxHA successfully treated 87,9% (87/99) of RUs (P = .125). CONCLUSIONS: DxHA and PPC showed no statistically significant differences neither in the number of injections needed nor in the total success rate after 12 months of follow-up.


Assuntos
Resinas Acrílicas/uso terapêutico , Cistoscopia , Dextranos/uso terapêutico , Ácido Hialurônico/uso terapêutico , Polímeros/uso terapêutico , Refluxo Vesicoureteral/tratamento farmacológico , Refluxo Vesicoureteral/cirurgia , Pré-Escolar , Feminino , Humanos , Masculino , Estudos Retrospectivos , Resultado do Tratamento
12.
Orv Hetil ; 159(42): 1700-1709, 2018 10.
Artigo em Húngaro | MEDLINE | ID: mdl-30334485

RESUMO

Dental amalgam has been used for more than 150 years due to its beneficial mechanical properties and durability in dentistry. In the past and to date, many questions about amalgam restorations have arisen, especially regarding the mercury content, which has been the subject of global disputes. By presenting the past and present of the 'amalgam issue', the aim of our paper is to display the current position of international literature. This summary is based on the publications in the PubMed database, the guidelines of the Council of European Dentists. Although the use of dental amalgam is widespread, concerns have been raised about the adverse effect on human health and the environment, focusing on its heavy metal pollution during waste treatment. In 2017, the European Union (EU) adopted the so-called Mercury Regulation, based on the United Nations Minamata Convention on Mercury, the recommendations of which are presented in the present review. This Regulation includes the requirement for EU Member States to develop a national action plan for the phase-down of amalgam. The feasibility plan for complete phase-out may be guaranteed by 2030. The authors discuss the advantages and disadvantages of possible amalgam alternatives by presenting glass-ionomers and resin-based composites. In the future, more material research programmes and long-term follow-up studies are necessary. In addition to several global health organizations, the Council of European Dentists also draws attention to prevent dental caries, expecting to reduce the number of restorations. Orv Hetil. 2018; 159(42): 1700-1709.


Assuntos
Resinas Acrílicas/uso terapêutico , Resinas Compostas/uso terapêutico , Amálgama Dentário/uso terapêutico , Restauração Dentária Permanente/métodos , Resinas Acrílicas/efeitos adversos , Resinas Compostas/efeitos adversos , Amálgama Dentário/efeitos adversos , Dentição Permanente , Humanos
13.
Zhonghua Kou Qiang Yi Xue Za Zhi ; 53(9): 579-584, 2018 Sep 09.
Artigo em Chinês | MEDLINE | ID: mdl-30196615

RESUMO

The curing light in direct composite resin adhesive restorations is a common technique and treatment method in oral clinic. It has many advantages, such as matching the color of the teeth, less removing the hard tissues of the teeth, resistance to abrasion, good masticatory performance and so on. It has almost replaced the traditional amalgam filling in the clinical dentistry repair. However, in clinical practice, improper use of the technique can also lead to increased loss of restorations and postoperative sensitivity. The reason is related not only to the physical and chemical properties of the material itself, but also the operator's lack of understanding and mastering the properties of the light cured material, especially the use rules of the light curing lamp. To this end, in September 2017, the vice chairman of Society of Cariology and Endodontology, Chinese Stomatological Association, professor Liang Jingping, organized a part of professional experts in this field, and invited the chief expert in 3M company, Dr. Joe Oxman, held a meeting about the use principle, operation mode and specification symposium of light curing lamp. Experts at the meeting had a very heated discussion, forming the following consensus.


Assuntos
Resinas Acrílicas/uso terapêutico , Resinas Compostas/uso terapêutico , Luzes de Cura Dentária/normas , Restauração Dentária Permanente/normas , Poliuretanos/uso terapêutico , Cor , Consenso , Restauração Dentária Permanente/métodos , Humanos
14.
Eur J Paediatr Dent ; 19(3): 247-249, 2018 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-30063160

RESUMO

Determining the best choice between the different sealant materials might be complicated. The products that dentists can choose have different properties, such as caries' preventive effect, fluoride release and retention rate. According to the literature, fissure sealant materials fall into two main categories: resin-based sealants and glass ionomer sealants. Even if the "fluoride-releasing resin sealants" are better than "glass ionomer", with regards to retention of the material, the literature shows that their effectiveness in preventing fissure caries in permanent molars does not differ significantly over 24 months.


Assuntos
Cárie Dentária/prevenção & controle , Selantes de Fossas e Fissuras/química , Selantes de Fossas e Fissuras/uso terapêutico , Resinas Acrílicas/química , Resinas Acrílicas/uso terapêutico , Criança , Cimentos de Ionômeros de Vidro/química , Cimentos de Ionômeros de Vidro/uso terapêutico , Humanos
15.
Zhonghua Kou Qiang Yi Xue Za Zhi ; 53(7): 437-442, 2018 Jul 09.
Artigo em Chinês | MEDLINE | ID: mdl-29996359

RESUMO

Objective: To evaluate and compare the caries prevention effectiveness of a resin-based sealant and a glass ionomer sealant on permanent first molars in 7- to 9-years-old school children. Methods: A randomized controlled, examiner-blinded, 5-year clinical trial was conducted in 19 primary schools in Dalian, Liaoning province. Totally 419 children (with 664 first molars) who had at least one sound permanent first molar with deep fissures or fissures with signs of non-cavitated lesions were recruited and stratified and allocated randomly into three parallel groups. A resin-based sealant was used in Group R (136 children with 219 first molars) and a glass ionomer sealant was used in Group G (130 children with 218 first molars). The third group (Group N, 153 children with 227 first molars) with none of the two sealants applied was served as blank control. Follow-up examinations were conducted at 0.5, 1, 2, and 5 years after sealing in order to assess the retention of the sealants and the incidence of caries occurrence. Chi-square test was adopted to compare the differences of caries incidence among the 3 groups. Generalized estimating equations (GEE) was used to analyze the effective factors of caries incidence. Results: During the 5-year follow-up period, 13.4% (23/172) of the teeth in Group R, 22.5% (40/178) of the teeth in Group G and 34.5% (57/165) of the teeth in Group N were diagnosed as having developed cavitated lesions. And the differences in the incidence of caries among the three groups was statistically significant (P<0.05). According to GEE, the resin-based sealant and the glass ionomer sealant were found to be the protection factors and the non-cavitated lesion before sealing was found to be the risk factor. The resin-based sealant was found to be the protection factor to the glass ionomer sealant when the blank control group was removed. Conclusions: Both resin-based sealant and glass ionomer sealant could effectively prevent the permanent first molars from the occurrence of carious lesions in 5 years. The resin-based sealant was superior to the glass ionomer sealant in caries prevention.


Assuntos
Resinas Acrílicas/uso terapêutico , Cárie Dentária/prevenção & controle , Cimentos de Ionômeros de Vidro/uso terapêutico , Selantes de Fossas e Fissuras/uso terapêutico , Dióxido de Silício/uso terapêutico , Criança , Seguimentos , Humanos , Dente Molar , Fatores de Tempo
16.
J Contemp Dent Pract ; 19(6): 631-636, 2018 Jun 01.
Artigo em Inglês | MEDLINE | ID: mdl-29959287

RESUMO

AIM: The purpose of the current study was intended to evaluate the effect of different surface modifications and different adhesive materials on the shear bond strength of artificial teeth to heat-polymerized and thermoplastic denture base materials using different repair techniques. MATERIALS AND METHODS: Forty cross-linked artificial teeth used to construct different types of acrylic based denture prosthesis were selected to be bonded to two types of denture base materials, heat-polymerized acrylic resin denture base material, and thermoplastic acrylic resin denture base material. The specimens were divided into four subgroups according to the repair technique and adhesive material used. The base surfaces of all acrylic teeth then were moistened with monomer prior to bonding to the denture base specimens. Then, the specimens were tested using Universal Testing Machine for shear bond strength. The results were analyzed by using two-way analysis of variance (ANOVA) statistical analysis and multiple comparison tests, α ≤ 0.05. RESULTS: The effect of the types of denture base materials vs the surface conditioning methods displayed a statistically significant difference. CONCLUSION: This study concluded that monomer surface treatment of the bonded surface of artificial denture teeth and the use of cyanoacrylate adhesive followed by additional microwave polymerization displayed better shear bond strength when compared with other repair techniques. CLINICAL SIGNIFICANCE: Artificial teeth debonding from their denture bases is a common complication in dental practice. The current study evaluates different repairing techniques. Within the limitation of this study, the use of cyanoacrylate adhesive in combination with microwave polymerization is one of the best techniques of repairing denture teeth debonding.


Assuntos
Adesivos/uso terapêutico , Retenção de Dentadura/métodos , Resinas Sintéticas/uso terapêutico , Resinas Acrílicas/uso terapêutico , Colagem Dentária/métodos , Análise do Estresse Dentário , Bases de Dentadura , Humanos , Resistência ao Cisalhamento , Dente Artificial
18.
ACS Nano ; 12(8): 7826-7837, 2018 08 28.
Artigo em Inglês | MEDLINE | ID: mdl-30016078

RESUMO

Myocardial infarction (MI), commonly known as a heart attack, affects millions of people worldwide and results in significant death and disabilities. A major cause of MI is fibrin-rich thrombus formation that occludes the coronary arteries, blocking blood flow to the heart and causing fibrin deposition. In treating MI, re-establishing blood flow is critical. However, ischemia reperfusion (I/R) injury itself can also occur and contributes to cardiac fibrosis. Fibrin-specific poly( N-isopropylacrylamide) nanogels (FSNs) comprised of a core-shell colloidal hydrogel architecture are utilized in this study to design a dual-delivery system that simultaneously addresses the need to (1) re-establish blood flow and (2) inhibit cardiac fibrosis following I/R injury. These therapeutic needs are met by controlling the release of a fibrinolytic protein, tissue plasminogen activator (tPA), and a small molecule cell contractility inhibitor (Y-27632). In vitro, tPA and Y-27632-loaded FSNs rapidly degrade fibrin and decrease cardiac cell stress fiber formation and connective tissue growth factor expression, which are both upregulated in cardiac fibrosis. In vivo, FSNs localize to fibrin in injured heart tissue and, when loaded with tPA and Y-27632, showed significant improvement in left ventricular ejection fraction 2 and 4 weeks post-I/R as well as significantly decreased infarct size, α-smooth muscle actin expression, and connective tissue growth factor expression 4 weeks post-I/R. Together, these data demonstrate the feasibility of this targeted therapeutic strategy to improve cardiac function following MI.


Assuntos
Resinas Acrílicas/uso terapêutico , Fibrose/tratamento farmacológico , Isquemia/tratamento farmacológico , Infarto do Miocárdio/tratamento farmacológico , Polietilenoglicóis/uso terapêutico , Polietilenoimina/uso terapêutico , Resinas Acrílicas/síntese química , Resinas Acrílicas/química , Animais , Fibrose/complicações , Fibrose/metabolismo , Isquemia/complicações , Isquemia/metabolismo , Infarto do Miocárdio/metabolismo , Infarto do Miocárdio/patologia , Nanogéis , Polietilenoglicóis/síntese química , Polietilenoglicóis/química , Polietilenoimina/síntese química , Polietilenoimina/química , Ratos
19.
Cell Stress Chaperones ; 23(6): 1337-1343, 2018 11.
Artigo em Inglês | MEDLINE | ID: mdl-29876727

RESUMO

Candida albicans causes opportunistic fungal infections usually hidden among more dominant bacteria and does not exhibit high pathogenicity in vivo. Among the elderly, due to reduced host resistance to pathogens attributable to immunoscenesence, oral candidiasis is more likely to develop often leading to systemic candidiasis. Surface pre-reacted glass ionomer filler (S-PRG filler) is an ion-releasing functional bioactive glass that can release and recharge six ions which in turn strengthens tooth structure, inhibits demineralization arising from dental caries, and suppresses dental plaque accumulation. However, its effects on C. albicans have never been elucidated. Here, we evaluated the effects of ion released from S-PRG filler on C. albicans. Results show that extraction liquids containing released ions (ELIS) decreased the amount of hydrogen peroxide and catalase activity in C. albicans. Moreover, ELIS presence was found to affect C. albicans: (1) suppression of fungal growth and biofilm formation, (2) prevent adherence to denture base resin, (3) inhibit dimorphism conversion, and (4) hinder the capability to produce secreted aspartyl proteinase. Taken together, our findings suggest that ELIS induces oxidative stress in C. albicans and suppresses its growth and pathogenicity. In this regard, we propose that ELIS has the potential to be clinically used to help prevent the onset and inhibition of oral candidiasis among the elderly population.


Assuntos
Resinas Acrílicas/farmacologia , Biofilmes/efeitos dos fármacos , Candida albicans/efeitos dos fármacos , Candidíase Bucal/prevenção & controle , Cimentos de Ionômeros de Vidro/farmacologia , Dióxido de Silício/farmacologia , Resinas Acrílicas/química , Resinas Acrílicas/uso terapêutico , Idoso , Ácido Aspártico Proteases/metabolismo , Candida albicans/crescimento & desenvolvimento , Candida albicans/patogenicidade , Catalase/antagonistas & inibidores , Adesão Celular/efeitos dos fármacos , Bases de Dentadura/microbiologia , Cimentos de Ionômeros de Vidro/química , Cimentos de Ionômeros de Vidro/uso terapêutico , Humanos , Íons/química , Íons/farmacologia , Íons/uso terapêutico , Estresse Oxidativo , Dióxido de Silício/química , Dióxido de Silício/uso terapêutico
20.
Vaccine ; 36(30): 4477-4484, 2018 07 16.
Artigo em Inglês | MEDLINE | ID: mdl-29909135

RESUMO

The Gram-negative pathogen toxigenic P. multocida causes progressive atrophic rhinitis (PAR) in swine throughout the world. Although some vaccines are being developed against PAR, their efficacy has not been evaluated using carbopol. In our study, a mixture of killed B. bronchiseptica and P. multocida bacteria, combined with recombinant proteins containing the C- and N-termini of PMT, was emulsified using two different adjuvants (ISA-15A and carbopol 971). The efficacy of these two vaccines was evaluated in a mouse model. Balb/C mice were immunized twice at a 14-day interval. Two weeks after the secondary immunization, blood samples were collected and the mice were challenged with toxigenic P. multocida. Thirty-five days later, the mice were euthanized, blood and tissue samples were collected. Compared with mice inoculated with vaccine emulsified with ISA-15A, higher titers of SN (1:64) and significantly increased levels of TNF-α, IL-6 and IL-17A were observed in mice inoculated with vaccine emulsified with the carbopol 971P. Especially, mice immunized with vaccine emulsified with the carbopol 971P had no detectable pathological changes in snouts or organs after challenge. The results demonstrated that carbopol adjuvanted vaccine provides good protection against PAR and P. multocida infection which can induce robust humoral and cell-mediated responses. We conclude that the carbopol adjuvanted vaccine is a good candidate for PAR prevention.


Assuntos
Resinas Acrílicas/uso terapêutico , Vacinas Bacterianas/uso terapêutico , Rinite Atrófica/imunologia , Rinite Atrófica/prevenção & controle , Animais , Ensaio de Imunoadsorção Enzimática , Feminino , Camundongos , Camundongos Endogâmicos BALB C , Infecções por Pasteurella/imunologia , Infecções por Pasteurella/prevenção & controle , Pasteurella multocida/imunologia , Pasteurella multocida/patogenicidade , Suínos
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