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1.
World Neurosurg ; 133: 104-111, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31568917

RESUMO

OBJECTIVE: To investigate the extent to which restraint is used in neurosurgical care, under what circumstances, and how it is documented. METHODS: A cross-sectional study with a mixed-methods approach was used to identify neurosurgical inpatients subjected to restraint. The data were collected in 2 phases: (1) a study-specific questionnaire was distributed to nurses in which they identified if restraints had occurred during their shifts, and if so, which restraint and to which patient; and (2) scrutinizing of electronic medical records of patients identified by the questionnaires. Numeric data were analyzed using descriptive and analytic statistical methods, and textual data were analyzed using qualitative content analysis. The findings from the different data sources were compared and merged. RESULTS: Of the 517 patients admitted to the studied department during the study period, 58 (11%) were reported to have been subjected to restraint and most of the restraining events occurred in the neurointensive care unit. Most restraint measures were not documented in the electronic medical records. The identified patients were predominantly diagnosed with traumatic brain injury or subarachnoid hemorrhage. The qualitative content analysis showed the circumstances when restraints were used: when patients were considered a danger to self or others (theme) and which symptoms and behaviors (categories) were observed in relation to the use of restraint. CONCLUSIONS: Restraint in neurosurgical care is mostly used to prevent patients from harming themselves or others. Because of the lack of documentation, restraint measures cannot be openly assessed, thus putting patients' safety at risk.


Assuntos
Neurocirurgia , Segurança do Paciente , Padrões de Prática Médica , Restrição Física , Adulto , Idoso , Idoso de 80 Anos ou mais , Atitude do Pessoal de Saúde , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Inquéritos e Questionários , Adulto Jovem
2.
J Clin Nurs ; 29(1-2): 5-19, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31495002

RESUMO

AIMS AND OBJECTIVES: To identify key determinants, which lead to the decision to apply physical or chemical restraint on the critical care unit. BACKGROUND: Psychomotor agitation and hyperactive delirium are frequently cited as clinical rationale for initiating chemical and physical restraint in critical care. Current restraint guidance is over a decade old, and wide variations in nursing and prescribing practice are evident. It is unclear whether restraint use is grounded in evidence-based practice or custom and culture. STUDY DESIGN: Integrative review. METHOD: Seven health sciences databases were searched to identify published and grey literature (1995-2019), with additional hand-searching. The systematic deselection process followed PRISMA guidance. Studies were included if they identified physical or chemical restraint as a method of agitation management in adult critical care units. Quality appraisal was undertaken using Mixed Methods Appraisal Tool. Data were extracted, and thematic analysis undertaken. RESULTS: A total of 23 studies were included. Four main themes were identified: the lack of standardised practice, patient characteristics associated with restraint use, the struggle in practice and the decision to apply restraint. CONCLUSIONS: There are wide variations in restraint use despite the presence of international guidance. Nurses are the primary decision-makers in applying restraint and report that caring for delirious patients is physically and psychologically challenging. The decision to restrain can be influenced by the working environment, patient behaviours and clinical acuity. Enhanced clinical support and guidance for nurses caring for delirious patients is indicated. RELEVANCE TO CLINICAL PRACTICE: Delirium and agitation pose a potential threat to patient safety and the maintenance of life-preserving therapies. Restraint is viewed as one method of preserving patient safety. However, use appears to be influenced by previous adverse experiences and subjective patient descriptors, rather than robust evidence-based knowledge. The need for a precise language to describe restraint and quantify when it becomes necessary is indicated.


Assuntos
Enfermagem de Cuidados Críticos/métodos , Tomada de Decisões , Agitação Psicomotora/enfermagem , Restrição Física/normas , Adulto , Delírio/enfermagem , Humanos , Unidades de Terapia Intensiva , Pessoa de Meia-Idade , Relações Médico-Enfermeiro , Restrição Física/efeitos adversos , Tranquilizantes/administração & dosagem
3.
BMC Complement Altern Med ; 19(1): 372, 2019 Dec 17.
Artigo em Inglês | MEDLINE | ID: mdl-31847849

RESUMO

BACKGROUND: Vernonia anthelmintica (L.) willd is a traditional urgur herb in China for a long history. Its alcohol extract (AVE) has been proved to promote hair follicle growth in C57BL/6 mice. We conducted this study to investigate the hair-growth effects of AVE in stressed mice and its possible mechanism of action. METHODS: The hair-follicle growth effects of AVE were examined by in vivo and in vitro study. We exposed C57BL/6 male mice to chronic restraint stress to induce murine hair follicle growth inhibition. The effects of AVE were examined by histological analysis, immunofluorescence for Ki67 and cytokeratin 19 immunoreactivity, western blot assay in tyrosinase and related proteins expressions and immunofluorescence for nerve fibers. In organ culture of mouse vibrissae follicles, we used substance P as a catagen-inducing factor of hair follicle growth, and measured the elongation of hair shafts and expression of neurokinin-1 receptor protein by application of AVE. RESULTS: Our results showed that AVE counteract murine hair follicle growth inhibition caused by chronic restraint stress via inducing the conversion of telogen to anagen and inhibiting catagen premature, increasing bulb keratinocytes and bulge stem cells proliferation, promoting melanogenesis, and reducing the numbers of substance P and calcitonin gene-related peptide nerve fibers. Furthermore, AVE also counteracted murine hair follicle growth inhibition caused by substance P in organ culture. CONCLUSION: These results suggest that AVE counteract stress-induced hair follicle growth inhibition in C57BL/6 mice in vivo and in vitro, and may be an effective new candidate for treatment of stress-induced hair loss.


Assuntos
Folículo Piloso/efeitos dos fármacos , Extratos Vegetais/farmacologia , Estresse Fisiológico/efeitos dos fármacos , Vernonia , Animais , Folículo Piloso/metabolismo , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Restrição Física
4.
J Indian Soc Pedod Prev Dent ; 37(4): 350-359, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31710009

RESUMO

Background: The goal of any good dental treatment is to provide a quality dental care to the patient. This may not be possible if the patient is unwilling to cooperate or unable to do so due to their age or related factors. In such children, behavior management techniques are very helpful. With changing times, there have been changes in the law and the outlook of parents and society toward dental treatment. This influences the various behavior management methods used by pediatric dentists. Objectives: This study was conducted to assess the attitudes of parents of children of different pediatric age groups towards: Behavior management techniques used by pediatric dentists The effect of maternal anxiety on the child's behavior in clinic Pharmacological behavior management techniques The effect of parental presence in the operatory on the child's behavior. Materials and Methods: Three hundred parents were evaluated and divided into three groups comprising 100 each on the basis of their children's age, Group A: 2-5 years, Group B: 6-9 years, and Group C: 10-13 years, which were further divided into two subgroups, on the basis of the child's gender, with each subgroup having parents of 50 male and 50 female children each. For example, Group A1: 50 parents of 2-5-year-old boys, Group A2: 50 parents of 2-5-year-old girls. Results: ANOVA test showed different hierarchies of acceptance for the techniques in all the groups. In all the three groups, tell show do, positive reinforcement, and live modeling were the most accepted techniques. However, statistically significant difference between the groups was not observed for the three techniques. The least accepted techniques for all the groups were hand over mouth technique and voice control technique. Conclusion: Parents were more receptive of those techniques which were visually more acceptable involving a communicative management, such as tell show do, positive reinforcement, and live modeling.


Assuntos
Odontopediatria , Restrição Física , Atitude , Criança , Comportamento Infantil , Pré-Escolar , Feminino , Humanos , Masculino , Pais
5.
Nat Neurosci ; 22(11): 1782-1792, 2019 11.
Artigo em Inglês | MEDLINE | ID: mdl-31636451

RESUMO

Microglia are the brain's resident innate immune cells and also have a role in synaptic plasticity. Microglial processes continuously survey the brain parenchyma, interact with synaptic elements and maintain tissue homeostasis. However, the mechanisms that control surveillance and its role in synaptic plasticity are poorly understood. Microglial dynamics in vivo have been primarily studied in anesthetized animals. Here we report that microglial surveillance and injury response are reduced in awake mice as compared to anesthetized mice, suggesting that arousal state modulates microglial function. Pharmacologic stimulation of ß2-adrenergic receptors recapitulated these observations and disrupted experience-dependent plasticity, and these effects required the presence of ß2-adrenergic receptors in microglia. These results indicate that microglial roles in surveillance and synaptic plasticity in the mouse brain are modulated by noradrenergic tone fluctuations between arousal states and emphasize the need to understand the effect of disruptions of adrenergic signaling in neurodevelopment and neuropathology.


Assuntos
Microglia/fisiologia , Plasticidade Neuronal/fisiologia , Norepinefrina/fisiologia , Córtex Visual/fisiologia , Animais , Benzilaminas/farmacologia , Receptor 1 de Quimiocina CX3C/genética , Movimento Celular/efeitos dos fármacos , Movimento Celular/fisiologia , Ritmo Circadiano/fisiologia , Clembuterol/farmacologia , Dexmedetomidina/farmacologia , Dominância Ocular , Feminino , Fentanila/farmacologia , Locus Cerúleo/efeitos dos fármacos , Masculino , Camundongos , Camundongos Transgênicos , Microglia/citologia , Microglia/efeitos dos fármacos , Nadolol/farmacologia , Plasticidade Neuronal/efeitos dos fármacos , Neurônios/metabolismo , Neurônios/fisiologia , Norepinefrina/metabolismo , Propanolaminas/farmacologia , Restrição Física/fisiologia , Terbutalina/farmacologia , Vigília , Ferimentos e Lesões/fisiopatologia
6.
Isr J Health Policy Res ; 8(1): 71, 2019 10 14.
Artigo em Inglês | MEDLINE | ID: mdl-31610806

RESUMO

Recently, Miodownik et al. reported in this journal the results of a study on seclusion and mechanical restraint of psychiatric patients in Israel (Isr J Health Policy Res 8:9, 2019). The study was a retrospective examination over a year of one inpatient ward in a psychiatric hospital. They found negative associations between length of use of coercive measures and the diagnosis of schizophrenia, being single, and the presence of academic nurses. Positive associations were found between length of use of coercive measures and the use of antipsychotic medications, violence towards oneself, and the use of restraint compared to seclusion. Interesting and important as they are, these results were obtained from data gathered in 2014. As the authors note, since then there has been a dramatic change in the official policy of the Israeli Ministry of Health on this topic and in the practice of seclusion and mechanical restraint in Israel. This commentary reviews and comments on the current situation.


Assuntos
Transtornos Mentais , Pessoas Mentalmente Doentes , Demografia , Humanos , Israel , Isolamento de Pacientes , Restrição Física , Estudos Retrospectivos
8.
Nursing ; 49(8): 53-55, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31343535

RESUMO

Nurses wearing hair up and out of the face may be seen as outdated, but proponents say keeping hair up is an evidence-based practice that contributes to infection prevention and optimal patient outcomes. This article raises questions concerning hair restraint and infection control and explores the evidence.


Assuntos
Cabelo , Enfermagem , Infecção Hospitalar/prevenção & controle , Prática Clínica Baseada em Evidências , Cabelo/microbiologia , Humanos , Controle de Infecções/métodos , Restrição Física
9.
Soins Pediatr Pueric ; 40(309): 27-29, 2019.
Artigo em Francês | MEDLINE | ID: mdl-31331598

RESUMO

Restraint may be used in paediatrics when it is necessary to perform a technical care procedure on a child who is agitated and refusing to cooperate. Obliged to restrain, caregivers are torn between respecting the child and fulfilling the order to perform the procedure. It is important to explore ways in which professionals can overcome this dilemma by finding alternatives. The discussion takes place at the heart of a care philosophy characterised by the notion of movement.


Assuntos
Pediatria , Restrição Física , Criança , Humanos
10.
Clin Ter ; 170(4): e245-e246, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31304509

RESUMO

The following letter addresses the issues of the applicability of physical restriction, with particular attention to the therapeutic regime and its meaning as a therapeutic or restrictive provision, while considering possible alternative measures in the context of Italian jurisprudence. The letter, in response to the questions posed by Cioffi and Tomassini, examines the possible legal implications for doctors and suggests that the integration of jurisprudence and psychiatry seems to be mandatory to define the operational protocols for the management of physical restraint. La seguente lettera affronta il problema relativo all'applicabilità della contenzione fisica, con particolare riferimento al regime terapeutico, nonché la sua valenza giuridica quale misura terapeutica o restrittiva, considerando eventuali approcci alternativi. La lettera, in risposta alle domande poste da Cioffi e Tomassini, esamina le possibili implicazioni legali cui possono incorrere i medici nell'applicare la contenzione fisica, suggerendo la necessità di un'integrazione tra le norme giurisprudenziale e la scienza psichiatrica, al fine di definire i protocolli operativi di gestione della contenzione fisica.


Assuntos
Restrição Física , Humanos , Itália
11.
Mol Med Rep ; 20(3): 2303-2315, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31322177

RESUMO

Restraint water­immersion stress (RWIS) can induce a gastric mucosal lesions within a few hours. The medial prefrontal cortex (mPFC) is involved in the RWIS process. The present study investigated the modulatory effects and molecular mechanisms of the mPFC on gastric function under an RWIS state. Male Wistar rats were divided into four groups; namely, the control, RWIS 4 h (RWIS for 4 h only), sham­operated and bilateral­lesioned (bilateral­lesioned mPFC) groups. The gastric erosion index (EI) and gastric motility (GM) were determined, and the proteomic profiles of the mPFC were assessed by isobaric tags for relative and absolute quantitation (iTRAQ) coupled with two­dimensional liquid chromatography and tandem mass spectrometry. Additionally, iTRAQ results were verified by western blot analysis. Compared with the RWIS 4 h group and the sham­control group, the bilateral­lesioned group exhibited a significantly lower EI (P<0.01). In the bilateral­lesioned group, RWIS led to a significant decrease in EI and GM. When comparing the control and RWIS 4 h groups, 129 dysregulated proteins were identified, of which 88 were upregulated and 41 were downregulated. Gene Ontology functional analysis demonstrated that 29 dysregulated proteins, including postsynaptic density protein 95, were directly associated with axon morphology, axon growth and synaptic plasticity. Ingenuity pathway analysis revealed that the dysregulated proteins were mainly involved in neurological disease signaling pathways, including the NF­κB and ERK signaling pathways. These data indicated that the presence of the mPFC exacerbates gastric mucosal injury in awake rats during RWIS. Although the quantitative proteomic analysis elucidated the nervous system molecular targets associated with the production of gastric mucosal lesions, such as the role of PSD95. The underlying molecular mechanisms of synaptic plasticity need to be further elucidated.


Assuntos
Mucosa Gástrica/fisiopatologia , Córtex Pré-Frontal/fisiopatologia , Úlcera Gástrica/etiologia , Estresse Psicológico/complicações , Animais , Masculino , Ratos Wistar , Restrição Física , Úlcera Gástrica/fisiopatologia , Estresse Psicológico/fisiopatologia
12.
J Forensic Leg Med ; 66: 134-137, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31301637

RESUMO

PURPOSE: The purpose of the work is to show and compare three reported cases of Excited Delirium Syndrome, which happened in Warsaw, Poland, from 2013 to 2017. We compared the results of three autopsy and toxicological findings of unexpectedly deceased males and the circumstances of their death, based on the police records. RESULTS: There were no significant findings of chronic diseases or multiple traumas leading us to the clear explanation of cause of death. We noted a rapid cardiopulmonary failure accompanied by drug abuse in all three cases, that happened following a stressful stimulus, evoked by a police restraint in prone position. All patients resembled similar external characteristics and BMI and had used drugs before death. CONCLUSION: A lack of the autopsy findings suggests the Excited Delirium Syndrome as a cause of death. The syndrome may be diagnosed after death, following the definition of exclusion of other somatic causes of death, preceded by symptoms during a stressful event. The syndrome occurs in overweight males, abusing especially stimulants. The physical restraint plays an important role in the initiation of the symptoms. The pathophysiology of the syndrome is poorly understood, but some theories underline dopamine transporters stimulation. To this day, there are no published Excited Delirium guidelines for forensic specialists or pathologists.


Assuntos
Morte Súbita/etiologia , Delírio/diagnóstico , Restrição Física/efeitos adversos , Transtornos Relacionados ao Uso de Substâncias/complicações , Adulto , Índice de Massa Corporal , Humanos , Masculino , Entorpecentes/análise , Obesidade/complicações , Polícia , Prisioneiros , Decúbito Ventral , Detecção do Abuso de Substâncias
13.
Psychiatr Prax ; 46(7): 406-408, 2019 Oct.
Artigo em Alemão | MEDLINE | ID: mdl-31284314

RESUMO

Coercive measures in psychiatry are used as a last resort if other means to avert imminent danger failed. Our case shows, that even if all precautions were taken complications may arise: We report about a young man, who had been restrained. After the belts had been partly loosened, he again became extremely aggressive. When the restraints had to be tightened he could grab and swallow the Segufix®-Metal Pin.


Assuntos
Agressão , Coerção , Restrição Física , Alemanha , Humanos , Masculino , Psiquiatria , Adulto Jovem
14.
Nord J Psychiatry ; 73(6): 331-339, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31264926

RESUMO

Background: A new short-term risk assessment instrument, the Mechanical Restraint - Confounders, Risk, Alliance Score (MR - CRAS) checklist, including three subscales with altogether 18 items, has been developed in close collaboration with forensic mental health nurses, psychiatrists' etc., and shows evidence of being comprehensible, relevant, comprehensive and easy to use for assessing the patient's readiness to be released from mechanical restraint. Aim: The aim of this study was to investigate whether the subscales: confounders, risk and parameters of alliance constituted separate subscales and needed further revisions. Materials and methods: MR - CRAS was field-study tested among nurses, nurse assistants and social and health care assistants in 13 Danish closed forensic mental health inpatient units, and a Mokken analysis of scalability and a Spearman correlation analysis were performed. Results: MR - CRAS was completed by clinicians in 143 episodes of mechanical restraint, representing 88 patients, with a mean duration of 63.25 hours. Most patients were younger men, diagnosed within the schizophrenia spectrum. One-third of the patients had repeated mechanical restraint episodes ranging between 2 and 8 episodes. MR - CRAS and especially the parameters of alliance were perceived as usable for assessment of the patient's readiness to be released from mechanical restraint. The psychometric analyses showed that the three subscales were unidimensional. Conclusions: The study shows evidence of the construct validity of MR - CRAS among clinicians at closed forensic mental health inpatient units. MR - CRAS contributes with a common language and structured, systematic and transparent observations and assessments on an hour by hour basis during mechanical restraint.


Assuntos
Saúde Mental , Restrição Física/psicologia , Medição de Risco/métodos , Adulto , Feminino , Humanos , Pacientes Internados/psicologia , Masculino , Enfermagem Psiquiátrica/métodos , Psicometria
15.
Emerg Med Clin North Am ; 37(3): 545-556, 2019 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-31262420

RESUMO

Mechanically ventilated patients can experience significant pain and anxiety associated with their care. These symptoms should be aggressively treated, but can be challenging to manage without a systematic approach. This article reviews recent literature, current guidelines, and best practices in managing pain, agitation, and anxiety in mechanically ventilated patients in the emergency department.


Assuntos
Hipnóticos e Sedativos/uso terapêutico , Manejo da Dor , Respiração Artificial , Algoritmos , Analgésicos/uso terapêutico , Ansiedade/prevenção & controle , Protocolos Clínicos , Medicina de Emergência , Serviço Hospitalar de Emergência , Humanos , Hipotensão/etiologia , Hipotensão/prevenção & controle , Medição da Dor , Agitação Psicomotora/terapia , Restrição Física , Estado Epiléptico/terapia
16.
Nursing (Säo Paulo) ; 22(254): 3052-3059, jul.2019.
Artigo em Português | LILACS, BDENF - Enfermagem | ID: biblio-1025935

RESUMO

Objetivo: Identificar na literatura os instrumentos para avaliação do uso de grades em pacientes hospitalizados e intervenções alternativas para reduzir as quedas do leito sem o uso de grades. Método: Revisão integrativa conforme diretrizes PRISMA, nas bases de dados: LILACS, Health Literature, MEDLINE/PUBMED, SCOPUS e SCIENCE DIRECT sem recorte temporal nos idiomas português, inglês e espanhol. Critérios de inclusão: população (adultos e idosos), intervenção (prevenção de quedas), desfecho (Instrumento de avaliação). Resultados: Foram selecionados quatro artigos que usavam um mesmo instrumento "Evaluation of Siderail Use" com abordagem detalhada na avaliação dos pacientes quanto ao uso de grades, discorre intervenções alternativas para o uso de grades que devem ser adaptadas às necessidades individuais. Conclusão: Estudos recomendam avaliação sistemática no processo de decisão sobre o uso das grades, que direcionem a prática clínica do enfermeiro para decidir por levantar ou não as grades, minimizando o uso desnecessário das grades como contenção mecânica.(AU)


Objective: Identify in the literature the instruments to evaluate the use of siderail in hospitalized patients and alternative interventions to reduce falls without use bedrail. Method: It was conducted an Integrative review of the literature according to the PRISMA guideline, carried out in the databases: LILACS, CINAHL, MEDLINE / PUBMED, SCOPUS and, SCIENCE DIRECT without temporal cut and in the idioms Portuguese, English and Spanish. Inclusion criteria: population (adults and the elderly), intervention (evaluation of the use of siderails), outcome (siderails use assessment tool); Exclusion criteria: articles of children and that did not deal with evaluation of the use of siderails. Results: It was selected four articles that used as intervention evaluations instruments for use of siderail. Conclusion: It was possible to verify a gap in the studies that approach instruments of evaluation of the use of siderail in hospitals. In addition, it is necessary to provide instruments to nurses to educate and train teams to decrease or eliminate the use of siderail as containment.(AU)


El objetivo fue caracterizar las atenciones a las urgencias psiquiátricas realizadas por el Servicio de Atención Móvil de Urgencia de Sobral, en 2017. Se tiene un abordaje cuantitativo, del tipo documental retrospectivo. La muestra fue compuesta por 301 fichas de ocurrencias utilizadas en las atenciones de los pacientes. Los datos fueron recolectados a través de un formulario y analizados a través del software IBM SPSS Statistics. Obtuvo un dictamen favorable por el CEP de la Santa Casa de Misericordia de Sobral. Se analizaron y discutieron datos referentes a sexo y grupo de edad, principales motivos de las ocurrencias, signos, síntomas y quejas presentados por los pacientes y desenlace de la ocurrencia. El elevado número de ocurrencias de emergencias psiquiátricas, evidenció la importancia de la discusión de los resultados de ese trabajo como una forma de mejorar la articulación e integración de la Red de Atención Psicosocial y la Red de Urgencia y emergencia, en el municipio, creando nuevas estrategias para minimizar las internaciones hospitalarios de los pacientes.(AU)


Assuntos
Humanos , Restrição Física , Assistência Hospitalar , Segurança do Paciente , Cuidados de Enfermagem , Guia de Prática Clínica
18.
Rev Infirm ; 68(250): 25-27, 2019 Apr.
Artigo em Francês | MEDLINE | ID: mdl-31147071

RESUMO

The association of the two terms 'isolating' and 'protecting', seems counterintuitive. The practice of isolation conjures up images of an asylum or even prison, rather than a notion of safeguarding. Isolation is defined within caregiving institutions by a vast range of practices, neither rare nor recent. It is used in a variety of departments, from psychiatric isolation to septic isolation or a form of isolation common to both: social isolation resulting from institutionalisation.


Assuntos
Prisões , Restrição Física , Hospitais Psiquiátricos , Humanos , Isolamento Social
19.
Rev Infirm ; 68(250): 28-30, 2019 Apr.
Artigo em Francês | MEDLINE | ID: mdl-31147072

RESUMO

Isolation and restraint both aim to protect the patient. Their practice, monitored and assessed, must meet ethical, legal, clinical and organisational requirements. It has its advantages (pacification) and its limits (loss of freedom to make choices about one's care).


Assuntos
Transtornos Mentais , Isolamento de Pacientes , Psiquiatria , Restrição Física , Humanos , Transtornos Mentais/terapia
20.
Bull Exp Biol Med ; 167(2): 226-228, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31236882

RESUMO

We studied the effects of Selank on intestinal microbiota in Wistar male rats subjected to chronic restraint stress. Selank was injected intraperitoneally in doses of 80, 250 and 750 µg/kg 15 min before stress exposure. Chronic restraint stress led to a decrease in the content of obligate microflora, while the content of opportunistic microorganisms increased. Selank restored intestinal microbiota presumably via central (neurotropic) and peripheral (immunotropic) mechanisms.


Assuntos
Colo/microbiologia , Microbioma Gastrointestinal/efeitos dos fármacos , Oligopeptídeos/uso terapêutico , Restrição Física/fisiologia , Animais , Modelos Animais de Doenças , Masculino , Ratos , Ratos Wistar
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