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1.
Vestn Oftalmol ; 137(2): 34-40, 2021.
Artigo em Russo | MEDLINE | ID: mdl-33881261

RESUMO

Multifocal electroretinography (mfERG) helps evaluate the electrical potential of the retina in a set of points within 30 degrees. There is a significant number of factors affecting the value of mfERG data, which should be taken into account in research studies. PURPOSE: To evaluate the difference and nature of changes in the amplitude (P1) and latency (P1, L1) parameters of mfERG in monocular (MS) and binocular stimulation (BS) in individuals with anisochromoartiphakia. MATERIAL AND METHODS: The study included 24 patients aged 76.3±7.9 years with anisochromoartiphakia [one eye - IOL with yellow spectrum SN60AT (yIOL); the other is a transparent IOL - Rayacryl (trIOL)] comprising the main group, and 16 patients without artiphakia aged 51.6±4.6 years in the control group [one eye with the addition of a yellow light filter (YF) ZHS1 - a spectral analog of SN60AT, the other - without YF]. Recording of mfERG was done with MS and BS. Parameters under evaluation were DP1 (nV/deg2), amplitude P1 (mV) and latency LP1, LN1 (ms) in rings R1-R5. RESULTS: In general, when switching from one ring to another under both types of stimulation and spectral correction, all indicators decrease. DP1 and P1 in MS and BS in the control group (49.2±17.7 and 53.6±17.5 nV/deg2) compared to the main group were higher (42.9±15.0 and 47.7±17.3 nV/deg2), LP1 and LN1 were shorter (41.2±5.0 and 44.8±4.3 ms in the control group, 44.0±4.1 and 50.7±21.1 ms in the main group). There was a significant difference between DP1R3 and DP1R4 in the control group (p≤0.003-0.050). In the control group without YF, P1R2 under MS was statistically significantly higher than under BS (p≤0.028). LP1 of R1, R3, R5 in the intergroup comparison was statistically significantly shorter in the control group without YF and MS (p≤0.033) and with YF in R1-R3, R5 (p≤0.003-0.023). LP1R2, LP1R4 were statistically significantly higher with trIOL in the main group under MS (p≤0.015; 0.047) and with yIOL in LP1R1, LP1R4, and LR5 (p≤0.053). The intergroup comparison showed that in the main group with yIOL, LP1R5 was statistically significantly lower under MS than BS (p≤0.032). When comparing LN1 between the groups, the statistically significant difference under MS without YF was observed in R5 (p≤0.002), while the difference under BS was insignificant. For YF, the increase in LN1 was statistically significant for MS in R2 and R3 (p≤0.010; 0.037) and for BS - in R1, R2 and R4 (p≤0.037; 0.003; 0.020). The intergroup comparison revealed that in the control group without YF, LN1R2 was statistically significantly lower under MS than BS (p≤0.028), and in the main group with trIOL, LN1R3 under MS was statistically significantly lower than under BS (p≤0.041). CONCLUSION: In anisochromoartiphakia, spectral differences in the optical environment of the eye lead to changes in the parameters of mfERG in the form of a decrease in DP1 and elongation of LP1 and LN1 in comparison with healthy eye and non-spectral intraocular correction. MS or BS in mfERG does not have a significant impact on the character and value of these parameters. The use of a single-stage binocular recording of mfERG reduces the duration of the study, which is especially important when examining elderly patients.


Assuntos
Eletrorretinografia , Retina , Idoso , Idoso de 80 Anos ou mais , Biometria , Humanos , Pessoa de Meia-Idade , Retina/diagnóstico por imagem , Visão Ocular
2.
Medicine (Baltimore) ; 100(16): e25618, 2021 Apr 23.
Artigo em Inglês | MEDLINE | ID: mdl-33879731

RESUMO

ABSTRACT: To investigate the relationship between visual resolution and cone parameters in eyes with different levels of best corrected visual acuity (BCVA).Seventeen eyes of 10 volunteers with BCVA of 20/12.5 or better (group 1) and 16 eyes of 10 volunteers with BCVA of 20/16 (group 2) were investigated in the study. Images of the cone photoreceptors at 1.5° from the fovea were obtained using an adaptive optics (AO) retinal camera. The BCVA was obtained following a subjective refraction using a standardized logMAR visual acuity chart.The mean cone density (29,570.96 ±â€Š2489.94 cells/mm2) at 1.5° from the fovea in group 1 (BCVA ≥ 20/12.5, n = 17) was significantly greater (P < .001) than that (22,963.59 ±â€Š2987.92 cells/mm2) in group 2 (BCVA = 20/16, n = 16). The cone spacing at 1.5° from the fovea in group 1 was 6.45 ±â€Š0.28 µm (mean ±â€ŠSD), which was significantly smaller (P < .001) than 7.36 ±â€Š0.50 µm (mean ±â€ŠSD) in group 2. In the stepwise regression analysis, greater angular cone density (odds ratio [OR], 4.48; P = .005) and smaller angular cone spacing (OR, 0.60; P = .007) at 1.5° from the fovea were significantly associated with the better BCVA.The greater cone density and smaller cone spacing at the parafovea were found in eyes with BCVA of 20/12.5 or better, as compared to that in eyes with BCVA of 20/16. Knowledge of cone distribution for different BCVA levels may be beneficial for different clinical conditions.


Assuntos
Imagem Óptica/métodos , Células Fotorreceptoras Retinianas Cones , Transtornos da Visão/diagnóstico por imagem , Acuidade Visual , Adulto , Estudos Transversais , Feminino , Fóvea Central/diagnóstico por imagem , Humanos , Masculino , Retina/diagnóstico por imagem , Adulto Jovem
3.
Adv Exp Med Biol ; 1256: 33-66, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-33847997

RESUMO

Age-related macular degeneration (AMD) is a progressive neuro-retinal disease and the leading cause of central vision loss among elderly individuals in the developed countries. Modern ocular imaging technologies constitute an essential component of the evaluation of these patients and have contributed extensively to our understanding of the disease. A challenge with any review of ocular imaging technologies is the rapid pace of progress and evolution of these instruments. Nonetheless, for proper and optimal use of these technologies, it is essential for the user to understand the technical principles underlying the imaging modality and their role in assessing the disease in various settings. Indeed, AMD, like many other retinal diseases, benefits from a multimodal imaging approach to optimally characterize the disease. In this chapter, we will review the various imaging technologies currently used in the assessment and management of AMD.


Assuntos
Degeneração Macular , Tomografia de Coerência Óptica , Idoso , Angiofluoresceinografia , Humanos , Degeneração Macular/diagnóstico por imagem , Degeneração Macular/terapia , Imagem Multimodal , Retina/diagnóstico por imagem
4.
Medicine (Baltimore) ; 100(10): e24670, 2021 Mar 12.
Artigo em Inglês | MEDLINE | ID: mdl-33725826

RESUMO

ABSTRACT: To report the rationale, design, and baseline demographic characteristics of TuYou-County Pediatric Eye study, which mainly aimed to determine the retinal microvascular changes with optical coherence tomography angiography (OCTA) and its association with eye abnormalities in school aged children and adolescents at suburban location in Northern China.TuYou-County Pediatric Eye study was a school-based survey conducted in TuYou-County. Multi-ethnic (Mongol, Han, and Hui) participants will be followed up for 5 years. Standardized ophthalmological examinations include visual acuity, ocular biometry, retinal photography, and OCTA. A questionnaire survey was conducted to collect variables regarding to eye disease such as parental history of eye diseases, near work, outdoor activities, living and eating habits, etc.After sampling, 687 participants were eligible for investigation, and 20 students did not attend the investigation, living 667 (response rate, 97.1%) students completed questionnaires and all ocular examinations. The average age of all participants was 14.9 ±â€Š5.11.TYPE study is the first large-scale school-based multi-ethnic survey in suburban site of Northern China. Continuous identification of retinal microvascular changes with eye diseases will provide new insights into the control related diseases in school-age children and adolescents.


Assuntos
Microvasos/diagnóstico por imagem , Projetos de Pesquisa , Retina/diagnóstico por imagem , Vasos Retinianos/diagnóstico por imagem , Transtornos da Visão/diagnóstico , Adolescente , Angiografia , Criança , China/epidemiologia , Feminino , Humanos , Incidência , Masculino , Prevalência , Instituições Acadêmicas/estatística & dados numéricos , População Suburbana/estatística & dados numéricos , Tomografia de Coerência Óptica , Transtornos da Visão/epidemiologia , Acuidade Visual
5.
J Vis Exp ; (168)2021 02 13.
Artigo em Inglês | MEDLINE | ID: mdl-33645555

RESUMO

The retina transforms light signals from the environment into electrical signals that are propagated to the brain. Diseases of the retina are prevalent and cause visual impairment and blindness. Understanding how such diseases progress is critical to formulating new treatments. In vivo microscopy in animal models of disease is a powerful tool for understanding neurodegeneration and has led to important progress towards treatments of conditions ranging from Alzheimer's disease to stroke. Given that the retina is the only central nervous system structure inherently accessible by optical approaches, it naturally lends itself towards in vivo imaging. However, the native optics of the lens and cornea present some challenges for effective imaging access. This protocol outlines methods for in vivo two-photon imaging of cellular cohorts and structures in the mouse retina at cellular resolution, applicable for both acute- and chronic-duration imaging experiments. It presents examples of retinal ganglion cell (RGC), amacrine cell, microglial, and vascular imaging using a suite of labeling techniques including adeno-associated virus (AAV) vectors, transgenic mice, and inorganic dyes. Importantly, these techniques extend to all cell types of the retina, and suggested methods for accessing other cellular populations of interest are described. Also detailed are example strategies for manual image postprocessing for display and quantification. These techniques are directly applicable to studies of retinal function in health and disease.


Assuntos
Fótons , Pupila/fisiologia , Retina/diagnóstico por imagem , Animais , Cálcio/metabolismo , Dependovirus/metabolismo , Processamento de Imagem Assistida por Computador , Injeções Intravítreas , Camundongos , Camundongos Transgênicos , Microglia/citologia , Células Ganglionares da Retina/citologia , Software
7.
Int J Mol Sci ; 22(4)2021 Feb 18.
Artigo em Inglês | MEDLINE | ID: mdl-33670772

RESUMO

Gene augmentation therapy is being planned for GUCY2D-associated Leber congenital amaurosis (LCA). To increase our understanding of the natural history of GUCY2D-LCA, patients were evaluated twice with an interval of 4 to 7 years between visits using safety and efficacy outcome measures previously determined to be useful for monitoring this disorder. In this group of molecularly-identified LCA patients (n = 10; ages 7-37 years at first visit), optical coherence tomography (OCT) was used to measure foveal cone outer nuclear layer (ONL) thickness and rod ONL at a superior retinal locus. Full-field stimulus testing (FST) with chromatic stimuli in dark- and light-adapted states was used to assay rod and cone vision. Changes in OCT and FST over the interval were mostly attributable to inter-visit variability. There were no major negative changes in structure or function across the cohort and over the intervals studied. Variation in severity of disease expression between patients occurs; however, despite difficulties in quantifying structure and function in such seriously visually impaired individuals with nystagmus, the present work supports the use of OCT as a safety outcome and FST as an efficacy outcome in a clinical trial of GUCY2D-LCA. A wide age spectrum for therapy was confirmed, and there was relative stability of structure and function during a typical time interval for clinical trials.


Assuntos
Guanilato Ciclase/genética , Amaurose Congênita de Leber/genética , Amaurose Congênita de Leber/fisiopatologia , Receptores de Superfície Celular/genética , Retina/patologia , Retina/fisiopatologia , Visão Ocular , Adolescente , Adulto , Criança , Fluorescência , Humanos , Amaurose Congênita de Leber/diagnóstico por imagem , Retina/diagnóstico por imagem , Células Fotorreceptoras Retinianas Cones/metabolismo , Tomografia de Coerência Óptica , Adulto Jovem
8.
Vestn Oftalmol ; 137(1): 46-52, 2021.
Artigo em Russo | MEDLINE | ID: mdl-33610149

RESUMO

PURPOSE: To evaluate the first outcomes of non-contact navigated laser retinopexy for peripheral tears and rhegmatogenous degenerations of the retina. MATERIAL AND METHODS: This prospective single-center interventional pilot study included 58 patients (68 eyes), among which 19 males and 39 females aged 47.5±16.9 years with peripheral retinal degenerations and symptomatic retinal tears who received non-contact laser retinopexy with the Navilas 577s navigated laser system and non-contact PRP widefield objective. All patients (68 eyes) underwent laser treatment for the following disorders: horseshoe tear in 13 eyes, retinal hole in 11 eyes, operculated retinal hole in 3 eyes, lattice degeneration in 19 eyes, snail track degeneration in 1 eye, vitreoretinal tufts in 16 eyes, and progressing bullous retinoschisis in 5 eyes. Pain intensity was assessed using a four-point verbal rating scale. RESULTS: All patients were followed up for 5 to 21 months (9.0±3.3 months on average). Stable condition of the retina was observed in 65 cases (95.5%). In 3 eyes (4.4%), newly formed retinal tears prompted additional laser treatment: horseshoe tear in 2 eyes and retinal hole in 1 eye. The mean pain score during non-contact navigated laser retinopexy was 0.9±0.5. No complications associated with laser treatment were observed. CONCLUSION: Non-contact navigated laser retinopexy performed with the Navilas 577s navigated laser system is a safe and well-tolerated procedure with effectiveness comparable to conventional laser retinopexy.


Assuntos
Descolamento Retiniano , Perfurações Retinianas , Adulto , Feminino , Humanos , Fotocoagulação a Laser , Lasers , Masculino , Pessoa de Meia-Idade , Projetos Piloto , Estudos Prospectivos , Retina/diagnóstico por imagem , Retina/cirurgia , Descolamento Retiniano/diagnóstico , Descolamento Retiniano/etiologia , Descolamento Retiniano/cirurgia , Perfurações Retinianas/diagnóstico , Perfurações Retinianas/etiologia , Perfurações Retinianas/cirurgia
9.
Vestn Oftalmol ; 137(1): 107-114, 2021.
Artigo em Russo | MEDLINE | ID: mdl-33610158

RESUMO

Chronic kidney disease (CKD) is a significant public health problem with a high risk of developing age-dependent eye diseases. Renal glomeruli and the choroid have similar structures and vascular networks; the internal hematoretinal barrier and the glomerular filtration barrier have similar developmental path; the renin-angiotensin-aldosterone hormonal system is found in both the eye and the kidneys. All this determines the similarity of physiological and pathogenetic features of the development of diseases associated with these organs. The article discusses general risk factors and pathophysiological mechanisms of development of retinal and renal lesions in CKD, the influence of various factors of pathogenesis on their development and progression. The anatomical similarity of vascularization, accompanied by microvascular changes in the retina and kidneys, leads to similar complications in both organs. Optical coherence tomography (OCT) and optical coherence tomography angiography (OCT-A) are accurate, well reproducible and non-invasive methods for diagnosing and assessing changes in the retinal microvascular bed, which make it possible to assess microvasculature changes in the kidneys. In CKD, the retina shows signs of impaired capillary perfusion, a decrease in their density, expansion of intercapillary spaces, a rarefaction of the density of the parafoveolar capillary network, which may indicate a decrease in peritubular capillary blood flow, blood circulation of the kidneys in general and their ischemia. Significant thinning of the retina and choroid, along with a decrease in macular volume, even in the initial stages of CKD, is accompanied by impaired renal function (changes in the estimated glomerular filtration rate and urinary albumin excretion), which is a sign of systemic microvascular lesion and pathological process in the kidneys. Therefore, monitoring of retinal vessels using OCT and OCT-A can become a reliable indicator of the progression of renal microvascular changes at any stage of the disease.


Assuntos
Insuficiência Renal Crônica , Vasos Retinianos , Corioide , Angiofluoresceinografia , Humanos , Insuficiência Renal Crônica/complicações , Insuficiência Renal Crônica/diagnóstico , Retina/diagnóstico por imagem , Vasos Retinianos/diagnóstico por imagem , Tomografia de Coerência Óptica
10.
Ideggyogy Sz ; 74(1-2): 57-63, 2021 Jan 30.
Artigo em Inglês | MEDLINE | ID: mdl-33497054

RESUMO

Background and purpose: The study aims to investigate the relationship between the progression of idiopathic Parkinson's disease (IPD) and retinal morphology. Methods: The study was carried out with 23 patients diagnosed with early-stage IPD (phases 1 and 2 of the Hoehn and Yahr scale) and 30 age-matched healthy controls. All patients were followed up at least two years, with 6-month intervals (initial, 6th month, 12th month, 18th month, and 24th month), and detailed neurological and ophthalmic examinations were performed at each follow-up. Unified Parkinson's Disease Rating Scale part III (UPDRS Part III) scores, Hoehn and Yahr (H&Y) scores, best-corrected visual acuity (BCVA), intraocular pressure (IOP) measurement, central macular thickness (CMT) and retinal nerve fiber layer (RNFL) thickness were analyzed at each visit. Results: The average age of the IPD and control groups was 43.96 ± 4.88 years, 44.53 ± 0.83 years, respectively. The mean duration of the disease in the IPD group was 7.48 ± 5.10 months at the start of the study (range 0-16). There was no statistically significant difference in BCVA and IOP values between the two groups during the two-year follow-up period (p> 0.05, p> 0.05, respectively). Average and superior quadrant RNFL thicknesses were statistically different between the two groups at 24 months and there was no significant difference between other visits (p=0.025, p=0.034, p> 0.05, respectively). There was no statistically significant difference in CMT between the two groups during the follow-up period (p> 0.05). Conclusion: Average and superior quadrant RNFL thicknesses were significantly thinning with the progression of IPD.


Assuntos
Doença de Parkinson , Adulto , Seguimentos , Humanos , Pessoa de Meia-Idade , Fibras Nervosas , Retina/diagnóstico por imagem , Tomografia de Coerência Óptica
11.
BMJ Case Rep ; 14(1)2021 Jan 06.
Artigo em Inglês | MEDLINE | ID: mdl-33408110

RESUMO

A 10-year-old boy underwent stem cell transplant for Hodgkin's lymphoma and developed vomiting and seizure in the postoperative period. An ophthalmic referral was made from intensive care unit, to rule out papilledema. On examination, there was no papilledema in both eyes, instead there were areas of retinal necrosis with no haemorrhages or vitritis in right eye. Cerebrospinal fluid serology was negative for herpes but MRI showed hyperintensity in temporal lobe. A clinical diagnosis of progressive outer retinal necrosis (PORN) was made and fundus picture was documented with help of a smartphone and 20D lens. High-dose intravenous injection acyclovir was started and PORN lesion improved on treatment.


Assuntos
Antivirais/administração & dosagem , Transplante de Medula Óssea/efeitos adversos , Infecções por Herpesviridae/diagnóstico , Doença de Hodgkin/terapia , Retina/patologia , Retinite/diagnóstico , Aciclovir/administração & dosagem , Criança , Diagnóstico Diferencial , Relação Dose-Resposta a Droga , Infecções por Herpesviridae/tratamento farmacológico , Infecções por Herpesviridae/imunologia , Doença de Hodgkin/imunologia , Humanos , Imunossupressores/efeitos adversos , Achados Incidentais , Imagem por Ressonância Magnética , Masculino , Necrose/diagnóstico , Necrose/tratamento farmacológico , Necrose/imunologia , Retina/diagnóstico por imagem , Retina/virologia , Síndrome de Necrose Retiniana Aguda/diagnóstico , Retinite/tratamento farmacológico , Retinite/imunologia , Resultado do Tratamento , Ativação Viral/imunologia
12.
J Med Case Rep ; 15(1): 15, 2021 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-33451352

RESUMO

BACKGROUND: Hyperreflective lesions at the level of ganglion cell (GCL) and inner plexiform retinal layers (IPL) by optical coherence tomography (OCT) and cotton wool spots in the examination of the eye fundus have recently been described as findings in patients with COVID-19 infection. CASE REPORT: We report the case of a 42-year-old healthy Caucasian male anesthetist who had treated COVID-19 patients during the previous 5 weeks and suddenly presented with a temporal relative scotoma in his left eye. Best-corrected visual acuity was 20/20 for the left eye, and no discromatopsy or afferent pupillary defect was present. Visual field test was performed, with no significant findings associated with the focal loss of sensitivity described by the patient. The anterior segment was unremarkable on slit lamp examination in both eyes. Fundus examination of the left eye showed no significant findings. A placoid, hyperreflective band at the level of the GCL and IPL was visible in OCT which spared the outer retina, at the time of diagnosis and 1 month later. An oropharyngeal swab test was performed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ribonucleic acid (RNA), immunoglobulin G (IgG) and immunoglobulin M (IgM) enzyme-linked immunosorbent assay (ELISA) determination. Real-time reverse-transcriptase polymerase chain reaction (RT-PCR) was negative. ELISA testing and a third rapid antibody detection test performed 7 days after the onset of symptoms were positive. CONCLUSIONS: Ocular signs and symptoms in COVID-19 cases are rarely reported, but may be underestimated, especially those that affect the retina and occur in asymptomatic or paucisymptomatic cases. We present a case of COVID-19 diagnosis based on retinal ophthalmic examination.


Assuntos
Fundo de Olho , Retina/diagnóstico por imagem , Escotoma , Tomografia de Coerência Óptica/métodos , Adulto , Infecções Assintomáticas , /diagnóstico , /métodos , Erros de Diagnóstico/prevenção & controle , Técnicas de Diagnóstico Oftalmológico , Humanos , Masculino , Escotoma/diagnóstico , Escotoma/etiologia , Acuidade Visual
14.
Exp Eye Res ; 203: 108394, 2021 02.
Artigo em Inglês | MEDLINE | ID: mdl-33310058

RESUMO

Micro-CT visualization allows reconstruction of eye structures with the resolution of light microscopy and estimation of tissue densities. Moreover, this method excludes damaging procedures and allows further histological staining due to the similar steps in the beginning. We have shown the feasibility of the lab-based micro-CT machine usage for visualization of clinically important compartments of human eye such as trabecular outflow pathway, retina, iris and ciliary body after pre-treatment with iodine in ethanol. We also identified the challenges of applying this contrasting technique to lens, cornea, and retina and proposed alternative staining methods for these tissues. Thereby this work provides a starting point for other studies for imaging of human eyes in normal and pathological conditions using lab-based micro-CT systems.


Assuntos
Enucleação Ocular , Olho/anatomia & histologia , Olho/diagnóstico por imagem , Microtomografia por Raio-X , Câmara Anterior/anatomia & histologia , Câmara Anterior/diagnóstico por imagem , Segmento Anterior do Olho/anatomia & histologia , Segmento Anterior do Olho/diagnóstico por imagem , Estudos de Viabilidade , Humanos , Imageamento Tridimensional , Cristalino/anatomia & histologia , Cristalino/diagnóstico por imagem , Retina/anatomia & histologia , Retina/diagnóstico por imagem
15.
Sensors (Basel) ; 20(24)2020 Dec 11.
Artigo em Inglês | MEDLINE | ID: mdl-33322285

RESUMO

Computational ghost imaging (CGI), with the advantages of wide spectrum, low cost, and robustness to light scattering, has been widely used in many applications. The key issue is long time correlations for acceptable imaging quality. To overcome the issue, we propose parallel retina-like computational ghost imaging (PRGI) method to improve the performance of CGI. In the PRGI scheme, sampling and reconstruction are carried out by using the patterns which are divided into blocks from designed retina-like patterns. Then, the reconstructed image of each block is stitched into the entire image corresponding to the object. The simulations demonstrate that the proposed PRGI method can obtain a sharper image while greatly reducing the time cost than CGI based on compressive sensing (CSGI), parallel architecture (PGI), and retina-like structure (RGI), thereby improving the performance of CGI. The proposed method with reasonable structure design and variable selection may lead to improve performance for similar imaging methods and provide a novel technique for real-time imaging applications.


Assuntos
Diagnóstico por Imagem , Processamento de Imagem Assistida por Computador , Retina/diagnóstico por imagem , Humanos
16.
Psychiatr Danub ; 32(3-4): 351-358, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33370732

RESUMO

BACKGROUND: Retina is considered as a window to the brain due to the similarities in terms of development and pathologies. Optical coherence tomography (OCT) can perform quantitative examinations in the retina. In this study, we aimed to investigate the effects of drugs used in schizophrenia and bipolar disorder (BD) on retinal nerve fiber layer (RNFL) and macular thickness. SUBJECTS AND METHODS: The study included schizophrenia (n=35) and euthymic BD (n=46) patients on various medications, and age, gender matched healthy control group (n=31). For retinal evaluation, measurements of RNFL and macula were performed with Optovue RTVue Premier OCT. RESULTS: In the schizophrenia group, chlorpromazine equivalent dose of antipsychotics was a statistically significant negative predictor of left RNFL nasal superior region thickness. In the BD group, serum valproate level was a significant positive predictor of thickness in the right macular inferior outer, left macular nasal outer region, right RNFL inferotemporal, left temporal and inferotemporal regions. CONCLUSION: Since the retina consists of neurons, morphological or functional examination of retina may be beneficial for the evaluation of the effects of psychopharmalogical treatments in schizophrenia and BD. The outcome of this study implies that valproate has neuroprotective effects on the optic nerve and macula, and this finding is consistent with the literature implying neurotrophic effects of valproate.


Assuntos
Transtorno Bipolar/diagnóstico por imagem , Transtorno Bipolar/tratamento farmacológico , Retina/efeitos dos fármacos , Retina/diagnóstico por imagem , Esquizofrenia/diagnóstico por imagem , Esquizofrenia/tratamento farmacológico , Tomografia de Coerência Óptica , Adulto , Feminino , Humanos , Macula Lutea/diagnóstico por imagem , Macula Lutea/efeitos dos fármacos , Masculino , Fibras Nervosas/efeitos dos fármacos
17.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 1360-1363, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018241

RESUMO

Registration of multimodal retinal images is of great importance in facilitating the diagnosis and treatment of many eye diseases, such as the registration between color fundus images and optical coherence tomography (OCT) images. However, it is difficult to obtain ground truth, and most existing algorithms are for rigid registration without considering the optical distortion. In this paper, we present an unsupervised learning method for deformable registration between the two images. To solve the registration problem, the structure achieves a multi-level receptive field and takes contour and local detail into account. To measure the edge difference caused by different distortions in the optics center and edge, an edge similarity (ES) loss term is proposed, so loss function is composed by local cross-correlation, edge similarity and diffusion regularizer on the spatial gradients of the deformation matrix. Thus, we propose a multi-scale input layer, U-net with dilated convolution structure, squeeze excitation (SE) block and spatial transformer layers. Quantitative experiments prove the proposed framework is best compared with several conventional and deep learningbased methods, and our ES loss and structure combined with Unet and multi-scale layers achieve competitive results for normal and abnormal images.


Assuntos
Algoritmos , Retina , Fundo de Olho , Retina/diagnóstico por imagem , Tomografia de Coerência Óptica
18.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 1592-1595, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018298

RESUMO

Clinically, the Fundus Fluorescein Angiography (FA) is a more common mean for Diabetic Retinopathy (DR) detection since the DR appears in FA much more contrasty than in Color Fundus Image (CF). However, acquiring FA has a risk of death due to the fluorescent allergy. Thus, in this paper, we explore a novel unpaired CycleGAN-based model for the FA synthesis from CF, where some strict structure similarity constraints are employed to guarantee the perfectly mapping from one domain to another one. First, a triple multi-scale network architecture with multi-scale inputs, multi-scale discriminators and multi-scale cycle consistency losses is proposed to enhance the similarity between two retinal modalities from different scales. Second, the self-attention mechanism is introduced to improve the adaptive domain mapping ability of the model. Third, to further improve strict constraints in the feather level, quality loss is employed between each process of generation and reconstruction. Qualitative examples, as well as quantitative evaluation, are provided to support the robustness and the accuracy of our proposed method.


Assuntos
Retinopatia Diabética , Retina , Atenção , Retinopatia Diabética/diagnóstico , Angiofluoresceinografia , Fundo de Olho , Humanos , Retina/diagnóstico por imagem
19.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 1863-1866, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018363

RESUMO

The deterioration of the retina center could be the main reason for vision loss. Older people usually ranging from 50 years and above are exposed to age-related macular degeneration (AMD) disease that strikes the retina. The lack of human expertise to interpret the complexity in diagnosing diseases leads to the importance of developing an accurate method to detect and localize the targeted infection. Approaching the performance of ophthalmologists is the consistent main challenge in retinal disease segmentation. Artificial intelligence techniques have shown enormous achievement in various tasks in computer vision. This paper depicts an automated end-to-end deep neural network for retinal disease segmentation on optical coherence tomography (OCT) scans. The work proposed in this study shows the performance difference between convolution operations and atrous convolution operations. Three deep semantic segmentation architectures, namely U-net, Segnet, and Deeplabv3+, have been considered to evaluate the performance of varying convolution operations. Empirical outcomes show a competitive performance to the human level, with an average dice score of 0.73 for retinal diseases.


Assuntos
Doenças Retinianas , Tomografia de Coerência Óptica , Idoso , Idoso de 80 Anos ou mais , Inteligência Artificial , Humanos , Redes Neurais de Computação , Retina/diagnóstico por imagem , Doenças Retinianas/diagnóstico por imagem
20.
Annu Int Conf IEEE Eng Med Biol Soc ; 2020: 1867-1870, 2020 07.
Artigo em Inglês | MEDLINE | ID: mdl-33018364

RESUMO

Automatic detection of age-related macular degeneration (AMD) from optical coherence tomography (OCT) images is often performed using the retinal layers only and choroid is excluded from the analysis. This is because symptoms of AMD manifest in the choroid only in the later stages and clinical literature is divided over the role of the choroid in detecting earlier stages of AMD. However, more recent clinical research suggests that choroid is affected at a much earlier stage. In the proposed work, we experimentally verify the effect of including the choroid in detecting AMD from OCT images at an intermediate stage. We propose a deep learning framework for AMD detection and compare its accuracies with and without including the choroid. Results suggest that including the choroid improves the AMD detection accuracy. In addition, the proposed method achieves an accuracy of 96.78% which is comparable to the state-of-the-art works.


Assuntos
Degeneração Macular , Tomografia de Coerência Óptica , Corioide/diagnóstico por imagem , Humanos , Degeneração Macular/diagnóstico por imagem , Retina/diagnóstico por imagem
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